CN102657304A - Health-care food with double functions of promoting digestion and relieving physical fatigue - Google Patents

Abstract

The invention belongs to the technical field of health-care foods, and in particular relates to a health-care food with double functions of promoting digestion and relieving physical fatigue and a preparation method thereof. The double-function health-care food is prepared from the following raw materials in parts by weight: 15 to 40 parts of mushroom, 20 to 60 parts of monkey head mushroom, 15 to 40 parts of toadstool, 6 to 20 parts of American ginseng, 10 to 20 parts of maythorn, 10 to 30 parts of Chinese date, 5 to 10 parts of xylo-oligosaccharide syrup, and 1 to 5 parts of taurine, and the raw materials can be manufactured into capsules, tablets, granules, oral solution and other preparations. The health-care food has the advantage of unique production proportion and processing process; and proven by animal test, the health-care food has double health-care functions of promoting digestion and relieving physical fatigue.

Description

A kind of have promote digestion and the bifunctional health food of alleviating physical fatigue

Technical field

The present invention relates to a kind of the have digestion of promotion and the bifunctional health food of alleviating physical fatigue and preparation method thereof, belong to the health food technology field.

Background technology

Indigestion is a kind of clinical syndrome, is by the caused disease of gastric motility disorder, comprises that also gastroparesis and esophageal regurgitation that peristole is bad are sick.Indigestion mainly is divided into functional dyspepsia FD and organic indigestion.

Functional dyspepsia FD is one group of general name of not having the chronic or intermittent gastrointestinal syndrome of organic reason, common epigastric pain or discomfort, after the meal glutted, belly flatulence, belch, early full, apocleisis, feel sick, symptoms such as vomiting, heartburn, sour regurgitation.This disease is modal a kind of functional intestines problem, accounts for 50% of GI Medicine outpatient service.

Organic indigestion: can clearly assert and cause indigestion symptom through inspection by certain organ lesion, like hepatopathy, disease of biliary tract, pancreatic disease, diabetes etc.

Dyspeptic therapeutic purposes are rapid relief of symptoms, improve patient's quality of life, remove inducement, recover normal physiological function, prevention of recurrence.At present, this type of disease generally should drug application be treated under the specialist instructs; Also can adopt OTC.Medicine commonly used has motilium, oryz aspergillus enzyme and pancreatin sheet and lactobacillin tablet, and its effect is respectively to increase medicine for stomach dynamic, supplementing digestive enzyme and promotion gastric secretion, strengthens digestive function.

Physical fatigue makes corporality tired again; Be since when the people for a long time, greatly during the physical exertion campaign of intensity; Produced a large amount of metabolins in the body, like lactic acid, carbon dioxide, serum urea nitrogen etc., this type material gathers in vivo; Stimulate human tissue cell and nervous system, will make the people produce sense of fatigue.

Alleviating fatigue product in the market roughly can be divided into following several types: the firstth, and makeup energy usually reaches and keeps the body normal physiological function, the purpose of relieving fatigue through replenishing the nutrition that is consumed in the motion.The secondth, the vitamin and the trace element of additional needed by human.The 3rd is that removing, the discharge of acceleration bodies intracellular metabolite material reach the alleviating physical fatigue purpose through the function of the function, the particularly circulatory system that improves biological organs.

The present invention overcomes the prior art deficiency, and a kind of the have digestion of promotion and the bifunctional health food of alleviating physical fatigue and preparation method thereof are provided.

Summary of the invention

The object of the invention provides a kind of the have digestion of promotion and the bifunctional health food of alleviating physical fatigue and preparation method thereof.

Said have promote digestion and the bifunctional health food of alleviating physical fatigue, contain following materials of weight proportions and process: mushroom 15-40 part, Hericium erinaceus 20-60 part, hickory chick 15-40 part, American Ginseng 6-20 part, hawthorn 10-20 part, red date 10-30 part, xylo-oligosaccharide are starched 5-10 part, taurine 1-5 part.

Said part is unit of weights such as g, kg, ton.

Said have promote digestion and the bifunctional health food of alleviating physical fatigue can add the auxiliary material that the health food relevant laws and regulations allow use, be prepared into formulations such as capsule, tablet, granule or oral liquid.

Said preparation method with promotion digestion and the bifunctional health food of alleviating physical fatigue may further comprise the steps:

(1) take by weighing following materials of weight proportions by prescription:

Mushroom 15-40 part, Hericium erinaceus 20-60 part, hickory chick 15-40 part, American Ginseng 6-20 part, hawthorn 10-20 part, red date 10-30 part, xylo-oligosaccharide slurry 5-10 part, taurine 1-5 part;

(2) mushroom in the raw material, Hericium erinaceus, hickory chick, American Ginseng, hawthorn, red date are mixed, adopt 70% reflow of alcohol of 5-10 times of weight to extract to separate after 3 hours filtrating and filter residue; Behind the recovered alcohol, filtrating is concentrated into the concentrate that proportion is 1.1-1.3, is numbered feed liquid A;

(3) above-mentioned filter residue is adopted 3-8 pure water doubly again, 65-85 ℃ was extracted 2 hours, separate filtrating and filter residue, the filtrating vacuum is concentrated into the concentrate that proportion is 1.1-1.3, is numbered feed liquid B;

(4) feed liquid A, B are mixed, 200 orders filter, and are prepared into mixed concentrated liquid C;

(5) mixed concentrated liquid C is processed former medicine dry powder behind centrifugal spray drying;

(6) by the proportioning of former medicine dry powder 20-60 part, xylo-oligosaccharide slurry 5-10 part, taurine 1-5 part, be prepared into formulations such as capsule, tablet, granule or oral liquid with other auxiliary materials.

Said auxiliary material is pharmaceutic adjuvants such as dextrin, mannitol or microcrystalline cellulose, or pure water and sweetener, acid etc.

Said have promote the bifunctional health food dose recommendation of digestion and alleviating physical fatigue every day 1-3 time; Oral liquid is 50-100ml/ time, and solid dosage forms is 2-6g/ time.

1, mushroom: be a kind of edible fungus.Being the fructification of Mycophyta door fungi mushroom, is one of famous in the world edible mushroom.Mushroom property is flat, flavor is sweet, goes into liver, stomach warp; The effect that filling liver kidney, strengthening the spleen and stomach, intelligence promoting and tranquilization, beauty treatment face are arranged.Have high protein, low fat, polysaccharide, several amino acids and multivitamin mushroom food, contain a large amount of vitamin Cs and Cobastab crowd, iron, potassium, provitamin D in the mushroom.

2, Hericium erinaceus: be one of four big famous dishes (hedgehog hydnum, bear's paw, sea cucumber, shark's fin).The title that " mountain delicacy hedgehog hydnum, seafood delights bird's nest " arranged.The property flat, flavor is sweet.Sharp the five internal organs are aid digestion; Have and be good for the stomach, qi-restoratives, anticancer, the effect of kidney-nourishing essence; Cure mainly illnesss such as anorexia and loose stool, gastric and duodenal ulcer, neurasthenia, cancer of the esophagus, cancer of the stomach, dizzy, impotence.Hericium erinaceus is a kind of high protein, low fat, be rich in a kind of good food of minerals and vitamins; Containing unrighted acid, can reduce cholesterolemia and content of triglyceride, regulate blood fat, be beneficial to blood circulation, is cardiovascular patient's ultimate food; The polysaccharide body that contains, polypeptide class and fatty material can suppress the synthetic of inhereditary material in the cancer cell, thus prevention and treatment alimentary tract cancer and other malignant tumours; Contain several amino acids and abundant polysaccharide body in the Hericium erinaceus, can be aid digestion, the nutritive effect of disease of digestive tracts such as gastritis, cancer of the stomach, cancer of the esophagus, gastric ulcer, duodenal ulcer is attracted people's attention.

3, hickory chick: be the herb of fungi plant medicine Morchellaceae plant hickory chick.It is sweet to distinguish the flavor of, and property is flat, goes into spleen, stomach two warps.Have with stomach help digestion, the regulating qi-flowing for eliminating phlegm effect.Being used for stagnation of QI due to dyspepsia, abdominal fullness and distention, phlegm stops up the circulation of vital energy in the wrong direction and breathes with cough.The nutrition of hickory chick is quite abundant, and according to surveying and determination, hickory chick contains crude protein 20%, crude fat 26%, carbohydrate 38.1%, also contains several amino acids, and particularly glutamic is up to 1.76%.Protein in the human body is made up of the collocation of 20 seed amino acids; And hickory chick just contains 18 kinds; Wherein 8 seed amino acids are that human body can not be made, but the important that on human nutrition, seems, so be referred to as " essential amino acid "; Therefore, the someone thinks " very good protein source ".In addition, hickory chick contains 8 kinds of vitamins at least according to surveying and determination: vitamin B1, vitamin B2, cobalamin, nicotinic acid, pantothenic acid, pyridoxol, biotin, folic acid etc.The nutrition of hickory chick can be suitable with cow's milk, meat and fish meal.Therefore, often claim that in the world it is one of " healthy food ".

4, American Ginseng: claim panacis quinquefolii radix, American ginseng again.American Ginseng is cold in nature; Sweet and slightly bitter taste is gone into lung, the spleen channel, has the function of boosting qi and nourishing yin, purging intense heat relieving restlessness, nourishing the stomach to improve the production of body fluid; Be applicable to the gas deficiency of Yin and the disease of fire is arranged, be used for after lung-heat type cough, the lazy speech of the deficiency of vital energy, four limbs burnout, irritated irritability, the pyreticosis impairment of yin body fluid loss etc. more.

5, hawthorn: flavor acid, sweet, slightly warm in nature.Return spleen, stomach, Liver Channel.Appetite-stimulating indigestion-relieving, long-pending, promoting blood circulation to remove blood stasis, the promoting the circulation of qi of reducing phlegm of disappearing change to stagnate.Be used for carnivorous stagnate long-pending, a lump in the abdomen causing distension and pain, the abdominal distension ruffian full, the stasis of blood resistance stomachache, phlegm and retained fluid, have loose bowels, discharging fresh blood stool etc.Lipase can promote lipolysis in the hawthorn; Crataegolic acids etc. can improve the activity of protease, the effect of helpful digestion.

6, red date: red date has another name called date, dried jujube, Chinese date, originates from China,, is just classified as one of " five fruits " (peach, Lee, plum, apricot, jujube) since ancient times in the China's plantation in existing more than 4,000 year history.Red date is rich in protein, fat, carbohydrate, carrotene, B family vitamin, vitamin C, citrin and nutritional labelings such as calcium, phosphorus, iron and CAMP.Wherein ascorbic content comes out at the top in fruit, and vitamin king's laudatory title is arranged.Eat the patient of date continuously, healthy recovery is faster more than 3 times than eating the vitamin medicament merely.The CAMP that red date contained is the essential composition of human body cell energetic supersession, can strengthen muscular strength, eliminates fatigue, hemangiectasis, increase myocardial contractive power, improve myocardial nutrition, to preventing and treating disease of cardiovascular system good effect is arranged; The traditional Chinese medicine theory thinks, red date has effects such as qi-restoratives benefit gas, nourishing blood and tranquilization, strengthening the spleen and stomach, is patient's good health care nutriment such as weakness of the spleen and the stomach, insufficiency of vital energy and blood, lassitude, insomnia and dreamful sleep.

7, xylo-oligosaccharide: claiming wood oligose again, is by the functional polymerization sugar of 2-7 wood sugar molecule with β-1,4 glycosidic bond be combined into.It is one of kind that propagation Bifidobacterium function is the strongest in the polymerization carbohydrate; Its effect property is nearly 20 times of other polymerization carbohydrates; The enzyme that does not have the hydrolysis xylo-oligosaccharide in the human gastrointestinal tract; So it can directly get into and be preferably Bifidobacterium in the large intestine and utilize, promote Bifidobacterium propagation to produce multiple organic acid simultaneously.Reduce the enteron aisle pH value, suppress harmful bacteria growing, probio is bred at enteron aisle in a large number.

8, taurine: claiming the 2-tarine again, is a kind of non-protein amino acid of sulfur-bearing, exists with free state in vivo, does not participate in the biosynthesis of albumen in the body.Taurine is a kind of special amino acid, is the requisite a kind of nutrient of human body; Except eyes, content of taurine is also the highest in the human heart in the human body.Taurine still is the short living factor of Bifidobacterium in the human body intestinal canal, optimizes bacterial flora structure in the enteron aisle.Taurine can be adjusted the amount of calcium ion among the cardiac muscle cell, keeps its balance, realizes cardiac stimulant.Taurine acts on the most significantly and just is enhance immunity power and antifatigue, and simultaneously, taurine can be kept cardiac function, makes blood circulation normalization, thereby eliminates tired product.

The food that the present invention utilizes in the daily life to be used always with benefiting action; In conjunction with modern nutrient; The health food that the unique prepared of employing the present invention goes out reaches following effect: ⑴ and organically combines through fungi and hawthorn, reaches appetite-stimulating indigestion-relieving, changes stagnant disappear long-pending and digestion promoting function; ⑵ adopt xylo-oligosaccharide and taurine benefit to give birth to the factor, regulates and optimize bacterial flora structure in the enteron aisle, reaches the effect that promotes digestion; ⑶ improve digestive function through improving functions of intestines and stomach, improves body nutrient absorption ability, through the additional relieving fatigue of nutrition; ⑷ stimulate circulation through improving cardiac function, improves nutrient delivery, reaches the effect of alleviating organism fatigue.

The present invention is not to use medicine and traditional material with alleviating physical fatigue and medicinal material; But the Combination Design through nutrition; Special processing technology; Prepare food,, reach promotion digestion and malaise, locomitivity due to overtired are hanged down inferior the alleviation and the improvement effect through improving the function of biological organs with health care.

Prove that through the security toxicological evaluation product of the present invention is nontoxic without any side effects; Through the function assessment test, product of the present invention meets " health food check and assessment technique standard " " promotion digestive function " and " alleviating physical fatigue function " evaluation index, has the double health function that promotes digestion and alleviating physical fatigue.

The specific embodiment

Embodiment 1

1, take by weighing following materials of weight proportions:

Mushroom 15kg, Hericium erinaceus 20kg, hickory chick 15kg, American Ginseng 6kg, hawthorn 10kg, red date 10kg, xylo-oligosaccharide slurry 5kg, taurine 5kg;

2, the mushroom in the above-mentioned raw materials, Hericium erinaceus, hickory chick, hawthorn, red date, American Ginseng are mixed, adopt 70% reflow of alcohol of 5 times of weight to extract to separate after 3 hours filtrating and filter residue; Behind the recovered alcohol, filtrating is concentrated into the concentrate that proportion is 1.2-1.25, is numbered feed liquid A;

3, above-mentioned filter residue is adopted again 5 times pure water, 65-85 ℃ was extracted 2 hours, separate filtrating and filter residue, the filtrating vacuum is concentrated into the concentrate that proportion is 1.2-1.25, is numbered feed liquid B;

4, feed liquid A, B are mixed, 200 orders filter, and are prepared into mixed concentrated liquid C;

5, mixed concentrated liquid C is processed former medicine dry powder behind centrifugal spray drying;

The proportioning of 6, starching 5kg, taurine 5kg by former medicine dry powder 30.4kg, xylo-oligosaccharide; Adopt the dissolved in purified water of 5 times of weight respectively; Add the xylitol of 60kg, the citric acid of 1.0kg and the pure water of 696.6kg again; After dissolving, mixing, carry out prepared such as can, sterilization and become oral liquid.

Embodiment 2

1, take by weighing following materials of weight proportions:

Mushroom 28kg, Hericium erinaceus 40kg, hickory chick 27kg, American Ginseng 13kg, hawthorn 15kg, red date 20kg, xylo-oligosaccharide slurry 7kg, taurine 3kg;

2, the mushroom in the above-mentioned raw materials, Hericium erinaceus, hickory chick, American Ginseng, hawthorn, red date are mixed, adopt 70% reflow of alcohol of 8 times of weight to extract to separate after 3 hours filtrating and filter residue; Behind the recovered alcohol, filtrating is concentrated into the concentrate that proportion is 1.2-1.25, is numbered feed liquid A;

3, above-mentioned filter residue is adopted again 4 times pure water, 65-85 ℃ was extracted 2 hours, separate filtrating and filter residue, the filtrating vacuum is concentrated into the concentrate that proportion is 1.2-1.25, is numbered feed liquid B;

4, feed liquid A, B are mixed, 200 orders filter, and are prepared into mixed concentrated liquid C;

5, mixed concentrated liquid C is processed former medicine dry powder behind centrifugal spray drying;

6, by former medicine dry powder 42.9kg, xylo-oligosaccharide slurry 7kg, taurine 3kg proportioning; Adopt 5 times dissolved in purified water respectively; Add the xylitol of 80kg, the citric acid of 1.5kg and the pure water of 601.1kg again, after dissolving, mixing, carry out prepared such as can, sterilization and become oral liquid.

Embodiment 3

1, take by weighing following materials of weight proportions:

Mushroom 40kg, Hericium erinaceus 60kg, hickory chick 40kg, American Ginseng 20kg, hawthorn 20kg, red date 30kg, xylo-oligosaccharide slurry 10kg, taurine 2kg;

2, the mushroom in the above-mentioned raw materials, Hericium erinaceus, hickory chick, hawthorn, red date, American Ginseng are mixed, adopt 70% alcoholic extraction of 10 times of weight, reflux separate after 3 hours filtrating and filter residue; Behind the recovered alcohol, be concentrated into the concentrate that proportion is 1.2-1.25, be numbered feed liquid A;

3, above-mentioned filter residue is adopted again 5 times pure water, 65-85 ℃ was extracted 2 hours, separate filtrating and filter residue, the filtrating vacuum is concentrated into the concentrate that proportion is 1.2-1.25, is numbered feed liquid B;

4, feed liquid A, B are mixed, 200 orders filter, and are prepared into mixed concentrated liquid C;

5, mixed concentrated liquid C is processed former medicine dry powder behind centrifugal spray drying;

6, by former medicine dry powder 60kg, xylo-oligosaccharide slurry 10kg, taurine 2kg proportioning; Adopt 5 times dissolved in purified water respectively; Add the xylitol of 80kg, the citric acid of 2kg and the pure water of 492kg again, after dissolving, mixing, carry out prepared such as can, sterilization and become oral liquid.

Instance 4

1, take by weighing following materials of weight proportions:

Mushroom 20kg, Hericium erinaceus 30kg, hickory chick 25kg, American Ginseng 10kg, hawthorn 12kg, red date 12kg, xylo-oligosaccharide slurry 8kg, taurine 2.5kg;

2, mushroom in the raw material, Hericium erinaceus, hickory chick, American Ginseng, hawthorn, red date are mixed, adopt 70% reflow of alcohol of 6 times of weight to extract to separate after 3 hours filtrating and filter residue; Behind the recovered alcohol, filtrating is concentrated into the concentrate that proportion is 1.25-1.3, is numbered feed liquid A;

3, above-mentioned filter residue is adopted again 4 times pure water, 65-85 ℃ was extracted 2 hours, separate filtrating and filter residue, the filtrating vacuum is concentrated into the concentrate that proportion is 1.25-1.3, is numbered feed liquid B;

4, feed liquid A, B are mixed, 200 orders filter, and are prepared into mixed concentrated liquid C;

5, mixed concentrated liquid C is processed former medicine dry powder behind centrifugal spray drying;

6, taurine 2.5kg is pulverized, cross 60 mesh sieves, mix, adopt xylo-oligosaccharide slurry 8kg, granulate as adhesive with the dextrin of former medicine dry powder 21.8kg and 29.8kg, drying, capsule product is processed in the direct can in whole grain back.

Instance 5

1, take by weighing following materials of weight proportions:

Mushroom 20kg, Hericium erinaceus 30kg, hickory chick 25kg, American Ginseng 10kg, hawthorn 12kg, red date 12kg, xylo-oligosaccharide slurry 8kg, taurine 2.5kg;

2, mushroom in the raw material, Hericium erinaceus, hickory chick, American Ginseng, hawthorn, red date are mixed, adopt 70% reflow of alcohol of 6 times of weight to extract to separate after 3 hours filtrating and filter residue; Behind the recovered alcohol, filtrating is concentrated into the concentrate that proportion is 1.25-1.3, is numbered feed liquid A;

3, above-mentioned filter residue is adopted again 4 times pure water, 65-85 ℃ was extracted 2 hours, separate filtrating and filter residue, the filtrating vacuum is concentrated into the concentrate that proportion is 1.25-1.3, is numbered feed liquid B;

4, feed liquid A, B are mixed, 200 orders filter, and are prepared into mixed concentrated liquid C;

5, mixed concentrated liquid C is processed former medicine dry powder behind centrifugal spray drying;

6, taurine 2.5kg is pulverized, cross 60 mesh sieves, mix with the mannitol of former medicine dry powder 21.8kg and 29.8kg, 8kg xylo-oligosaccharide slurry as adhesive, is granulated, drying is prepared into particle product after whole.

Instance 6

1, take by weighing following materials of weight proportions:

Mushroom 20kg, Hericium erinaceus 30kg, hickory chick 25kg, American Ginseng 10kg, hawthorn 12kg, red date 12kg, xylo-oligosaccharide slurry 8kg, taurine 2.5kg;

2, mushroom in the raw material, Hericium erinaceus, hickory chick, American Ginseng, hawthorn, red date are mixed, adopt 70% reflow of alcohol of 6 times of weight to extract to separate after 3 hours filtrating and filter residue; Behind the recovered alcohol, filtrating is concentrated into the concentrate that proportion is 1.25-1.3, is numbered feed liquid A;

3, above-mentioned filter residue is adopted again 4 times pure water, 65-85 ℃ was extracted 2 hours, separate filtrating and filter residue, the filtrating vacuum is concentrated into the concentrate that proportion is 1.25-1.3, is numbered feed liquid B;

4, feed liquid A, B are mixed, 200 orders filter, and are prepared into mixed concentrated liquid C;

5, mixed concentrated liquid C is processed former medicine dry powder behind centrifugal spray drying;

6, taurine 2.5kg is pulverized, cross 60 mesh sieves, mix, adopt xylo-oligosaccharide slurry 8kg, granulate as adhesive with the microcrystalline cellulose of former medicine dry powder 21.8kg and 17.88kg, drying, after whole, compression molding is prepared into tablet product.

Product health care of the present invention clinical testing

One, product of the present invention promotes the digestive function test

1, materials and methods

Male Kunming strain mice, body weight 18～22g, SPF level, SD male rat, body weight 120～150g, SPF level.After mouse adaptability fed for 1 week, be divided into 4 batches (48 every batch) at random, the every batch of animal is divided into control group, the invention basic, normal, high dose groups of product (12 every group) at random, with the prepared capsule of embodiment 4 as the animal experiment sample.Testing basic, normal, high dosage (0.75,1.5,3g/ (kg bwd)) (be equivalent to respectively human body RD 5,10 and 20 times) group irritates stomach respectively and gives sample; Irritate the long-pending 0.2g/10g of body of stomach; Control group gives distilled water; 30d according to Ministry of Health of the People's Republic of China's " health food check and assessment technique standard " (2003) method, carries out rat body weight, weight gain, food ration and food utilization experiment respectively continuously; The intestinal motility experiment; Three part tests such as the mensuration of digestive ferment.Compare article with commercially available R-1132 as model.

2, result of the test

2.1 the influence of intestinal motility experiment (prepared Chinese ink propelling rate): model control group prepared Chinese ink propelling rate significantly is lower than blank control group (P＜0.05), mouse constipation model is set up.The invention product is irritated the middle and high dose groups mouse of stomach mouse 15d prepared Chinese ink propelling rate and is significantly higher than model control group (P＜0.01), and each organizes the prepared Chinese ink propelling rate of mouse, sees table 1.

The influence of table 1 pair mouse prepared Chinese ink propelling rate (x ± s)

Group	Blank control group	Model control group	Low dose group	Middle dose groups	High dose group
						Prepared Chinese ink impelling ratio (%)	0.58±0.028	0.52±0.024	0.52±0.015	0.52±0.015	0.62±0.016
Prepared Chinese ink propelling rate	0.86±0.029①	0.78±0.024①	0.76±0.015	0.85±0.015②	0.91±0.016②

Annotate: compare with the blank group, 1. P＜0.05,2. P＜0.01

2.2 influence to rat body weight, weight gain, food ration and food utilization.

2.2.1 the influence to body weight: the high dose group rat body weight all is significantly higher than blank control group (P＜0.01), is significantly higher than blank control group ((P＜0.05) in observing end of term high dose group rat body weight; The growth of high dose group rat TBW is significantly higher than blank control group (P＜0.01), sees table 2.

The effect of table 2 pair rat body weight (x ± s)

Annotate: compare with the blank group, 1. P＜0.05,2. P＜0.01

2.2.2 the influence to food ration: the invention product has the effect of the rat of increasing food ration.See table 3.

The effect of table 3 pair rat food ration (x ± s)

Annotate: compare with the blank group, 1. P＜0.05,2. P＜0.01

2.2.3 influence:, see table 4 for the not obviously influence of rat food utilization to food utilization.

The effect of table 4 pair rat food utilization (x ± s)

2.3 the influence to the rat digestive ferment: high dose group rat stomach liquid measure is remarkable, is higher than blank control group (P＜0.05); Middle and high dose groups rat stomach protease discharge rate all is significantly higher than blank control group (P＜0.01), sees table 5.

The effect of table 5 pair rat digestive ferment (x ± s)

Group	2 hours gastric juice amounts (ml)	Peptic activity of stomach (U/mL)	Pepsin discharge rate (U/h)
				Blank control group	2.0±0.4	21.3±2.1	42.1±3.4
Low dose group	2.2±0.4	22.0±1.9	45.2±2.8
				Middle dose groups	2.2±0.3	22.4±2.1	47.4±2.4②

High dose group

2.4±0.5①

22.9±2.4

49.0±3.6②

Annotate: compare with the blank group, 1. P＜0.05,2. P＜0.01

This experiment selects for use rat to carry out zoopery, adopts instance 4 samples of the present invention to rat body weight, weight gain, food ration and food utilization, the rat gastric secretion, and the influence of gastric juice digestive enzyme activity experimentizes.This experimental studies results confirms, continuous irrigation stomach rat 30d, and rat body weight obviously increases weight, and food ration obviously increases, the gastric secretion showed increased.Show and adopt the prepared product of the present invention that rat is had the digestive function of promotion health-care effect.

Two, product alleviating physical fatigue function test of the present invention

1, method

1.1 animal used as test divides into groups and medication.

After mouse adaptability fed for 1 week, be divided into 4 batches (48 every batch) at random, the every batch of animal is divided into control group, the invention basic, normal, high dose groups of product (12 every group) at random, with the prepared capsule of embodiment 4 as the animal experiment sample.Testing basic, normal, high dosage (0.75,1.5,3g/ (kg bwd)) (be equivalent to respectively human body RD 5,10 and 20 times) group irritates stomach respectively and gives sample; Irritate the long-pending 0.2g/10g of body of stomach; Control group gives distilled water; 30d according to Ministry of Health of the People's Republic of China's " health food check and assessment technique standard " (2003) method, carries out swimming with a load attached to the body experiment, serum urea nitrogen, hepatic glycogen, blood lactic acid content determination experiment respectively continuously.

1.2 index detects

Measure the animal swimming with a load attached to the body time; Serum urea nitrogen (BUN) assay adopts sharp Bath AU400 automatic clinical chemistry analyzer difficult to understand; Hepatic glycogen, blood lactic acid content are measured by the kit specification.

2, test data

Table 6 pair mice serum urea nitrogen content, hepatic glycogen content and the influence of swimming with a load attached to the body time (x ± s, n=12)

Annotate: each dose groups mice serum urea nitrogen content of sample all is lower than control group, and wherein the difference of high dose, middle dose groups and negative control group has conspicuousness meaning (P < 0.05).Heavy burden (5%) swimming time of each dose groups mouse of sample all prolongs than negative control group, and wherein the difference of high dose, middle dose groups and negative control group has highly significant property meaning (P < 0.01).

Table 6 shows that behind the dose groups mouse swimming with a load attached to the body 90min, serum urea nitrogen is lower than control group, and difference has conspicuousness in the product of the present invention; Middle and high dose groups Mouse Liver glycogen levels all is higher than control group, and difference has conspicuousness, shows that product of the present invention can reduce motion back serum urea nitrogen level, and can increase the hepatic glycogen deposit of mouse.Each dose groups mouse swimming with a load attached to the body time all prolongs than control group, and difference has conspicuousness.

The influence of table 7 pair mouse blood lactic acid content (x ± s, n=12)

Annotate: (1) each dose groups and control group relatively have significant difference, P＜0.01

Table 7 shows; Irritate each dose groups mouse swimming back 0 of stomach outturn sample of the present invention, 20min blood lactic acid content and control group reduction is more all arranged; Wherein swimming back 20min high dose group blood lactic acid content and control group relatively have statistical significance (P＜0.01); TG-AUC and control group are apparent in view to be reduced, and difference has statistical significance (P＜0.01).

Conclusion (of pressure testing): this animal experiment study is the result show, product of the present invention can increase the animal's liver glycogen contents deposit, prolongs the animal swimming with a load attached to the body time, reduces serum urea nitrogen and blood lactic acid content, explains that product of the present invention has effect of relieving physical fatigue.

Claims (2)

1. one kind has the digestion of promotion and the bifunctional health food of alleviating physical fatigue; It is characterized in that, contain following materials of weight proportions and process: mushroom 15-40 part, Hericium erinaceus 20-60 part, hickory chick 15-40 part, American Ginseng 6-20 part, hawthorn 10-20 part, red date 10-30 part, xylo-oligosaccharide slurry 5-10 part, taurine 1-5 part.

2. the preparation method with promotion digestion and the difunctional health food of alleviating physical fatigue according to claim 1 is characterized in that,

(1) take by weighing following materials of weight proportions by prescription:

Mushroom 15-40 part, Hericium erinaceus 20-60 part, hickory chick 15-40 part, American Ginseng 6-20 part, hawthorn 10-20 part, red date 10-30 part, xylo-oligosaccharide slurry 5-10 part, taurine 1-5 part;

(2) mushroom in the raw material, Hericium erinaceus, hickory chick, American Ginseng, hawthorn, red date are mixed, adopt 70% reflow of alcohol of 5-10 times of weight to extract to separate after 3 hours filtrating and filter residue; Behind the recovered alcohol, filtrating is concentrated into the concentrate that proportion is 1.1-1.3, is numbered feed liquid A;

(3) above-mentioned filter residue is adopted 3-8 pure water doubly again, 65-85 ℃ was extracted 2 hours, separate filtrating and filter residue, the filtrating vacuum is concentrated into the concentrate that proportion is 1.1-1.3, is numbered feed liquid B;

(4) feed liquid A, B are mixed, 200 orders filter, and are prepared into mixed concentrated liquid C;

(5) mixed concentrated liquid C is processed former medicine dry powder behind centrifugal spray drying;

(6) by the proportioning of former medicine dry powder 20-60 part, xylo-oligosaccharide slurry 5-10 part, taurine 1-5 part, be prepared into formulations such as capsule, tablet, granule or oral liquid with other auxiliary materials.