Background technology
Cough is unclear for lung qi, loses in a surname respectfully, and superinverse is uttered a word and caused that cough is for its Characteristics of Syndromes.Coughing, coughing up phlegm is the cardinal symptom of assertive evidence.Due to the difference of the cause of disease and reactivity of organism, there is corresponding symptom and feature.The cough that diseases caused by exogenous pathogenic factor cause, cough up phlegm mostly with heating, headache, aversion to cold etc., onset is more anxious, and the course of disease is shorter; Internal injury is cough caused, and generally, without diseases caused by exogenous pathogenic factor symptom, onset is slow, and the course of disease is long, the normal syndrome with visceral dysfunction.Its various diseases are violated lung as: wind and cold, early stage itching throat cough and cough low voice speaking, out of breath, coughing up thin sputum show bubble, or stuffy nose with watery discharge, white and thin fur, floating pulse; If from transconversion into heat, expectorant and nasal mucus are by Bai Zhuanhuang.Wind-heat invading the lung, common cough expectorant is yellow and thick, rough, or pharyngalgia, thirsty, or stream yellow thick nasal discharge, yellow and thin fur, floating and rapid pulse.Pathogenic dryness impairing the lung, dry cough without phlegm or few expectorant, nasopharynx is dry, the dry few Tianjin of red tongue, rapid pulse.Phlegm dampness in lungs, heavy cough, suffocated breathing uncomfortable in chest, the white thickness of abundant expectoration color, white and greasy fur, soft pulse is sliding.Expectorant heat stagnation lung, coughs up phlegm yellow thick, tachypnea uncomfortable in chest, yellowish fur, slippery and rapid pulse.Liver-fire invading the lung, QI rising in reverse order cough, coughs and draws hypochondriac pain, the few Tianjin of yellow fur, wiry and frequent pulse.Lung yin loss, dry cough without phlegm, or see spitting of blood, the few tongue of red tongue, thready and rapid pulse.
The present invention is intended to inquire into a kind of Chinese medicine composition that is used for the treatment of cough, cures mainly wind-heat invading the lung and pathogenic dryness impairing the lung.Such cough is relevant with invasion and attack and the visceral dysfunction of exopathogen.Said as < < three-character medical verses > >: " canopy that lung is internal organs; that exhales is empty, suctions full are only subject to obtain this dirty healthy energy; must not be subject to external courteous, courteous choking and coughing of doing; Also be only subject to obtain the clearing heat in QI system of internal organs, must not be subject to the pathogenic QI in the body of internal organs, pathogenic QI in the body is done it, also chokes and coughs." cough the cause of disease, the one, the heresy of diseases caused by exogenous pathogenic factor six climate exopathogens; The 2nd, the pathogenic QI in the body of internal organs, all can cause that lung qi is unclear to lose in a surname respectfully, compels gas superinverse and coughs.
Wind-heat invading the lung and pathogenic dryness impairing the lung (be called for short wind-dryness impairing the lung) cough is attacked lung for exopathogen, diseases caused by exogenous pathogenic factor six climate exopathogens, from mouth and nose or fur and enter, lung qi is restrainted, impairment of purifying and descending function of the lung, < < interchannel six scripts cough opinion > > meaning: " cold, summer-heat, dry, wet, wind, fiery six gas, all make us coughing " is this meaning.Due to 4 o'clock angry differences, thereby the pathogenic exopathogen that human body is experienced was also had any different.Wind is first of six climate exopathogens, and other exopathogen are many with ailment said due to cold or exposure invasion and attack human body, and wind being YANG-pathogen, for a long time must dryness-transformation, and dry Sheng Tianjin wound, air flue loses in moistening foster, and dry cough itching of the throat is repeatedly difficult, if the plain body deficiency of YIN, body fluid deficiency is more contained.So exogenous cough Chang Yifeng is guide, or hold under the arm coldly, or hold heat under the arm, or hold under the arm dryly, wherein especially with ailment said due to cold or exposure, hold cold person under the arm in the majority.Zhang Jingyue is said: " six gas all make us coughing, and wind and cold is main.
Cough due to diseases caused by exogenous pathogenic factor, all involves lungs and is subject to disease, by lung qi unclear lose in a surname respectful due to, therefore < < Jing Yue's complete work cough > > says: " though cough demonstrate,prove many, pneumonopathy nothing but." < < Medicine Comprehended > > points out: " lung body belongs to gold, such as Zhong Ran, Zhong Fei kowtows and does not ring, the heresy of wind and cold heat-damp in summer dryness-fire six climate exopathogens, from the ring of hitting outward, labor is wanted feelings will, and diet is processed fire also the ringing from inside fire attack of fighting." prompting cough is that inside and outside pathogenic factor is violated lung, lungs are for eliminating evil outer the produced a kind of pathological reaction that reaches.Exogenous cough belongs to the domination of pathogen, and for exopathogen is violated lung, due to sluggishness of lung-QI is smooth, if can not make in time, heresy is outer reaches, can further occur to develop to transform, and the heat-transformation of performance wind and cold, wind heat dryness-transformation, or lung-heat steaming liquid becomes the situations such as expectorant.
Chinese medicine is the rarity in Chinese traditional culture, Chinese medicine is for conditioning organ function, coordinate each internal organs and have original advantage, therefore, the invention provides and aim to provide a kind of nourishing YIN to relieve dryness, dispelling wind and heat pathogens, dispels the wind and gets rid of evils, significant a kind of Chinese medicine composition for the treatment of cough for the treatment of wind-dryness impairing the lung type cough effect and preparation method thereof.
Summary of the invention
Technical problem to be solved by this invention is, a kind of nourishing YIN to relieve dryness is provided, and dispelling wind and heat pathogens, dispels the wind and get rid of evils, significant a kind of Chinese medicine composition for the treatment of cough for the treatment of wind-dryness impairing the lung type cough effect and preparation method thereof.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of cough, wherein, each crude drug is as follows according to unit of weight configuration: Folium Eriobotryae 10-20g, Radix Ophiopogonis 10-20g, Radix Adenophorae 5-15g, Folium Mori 5-15g, Semen Armeniacae Amarum 5-15g, Herba Menthae 3-10g, Rhizoma Anemarrhenae 5-15g, Periostracum Cicadae 3-10g, Bombyx Batryticatus 5-15g, Folium Perillae 5-15g, Bulbus Fritillariae Thunbergii 1-4g, Radix Glycyrrhizae 3-10g.
Or each crude drug is as follows according to unit of weight proportioning: Folium Eriobotryae 10-15g, Radix Ophiopogonis 10-15g, Radix Adenophorae 5-10g, Folium Mori 5-10g, Semen Armeniacae Amarum 5-10g, Herba Menthae 3-5g, Rhizoma Anemarrhenae 5-10g, Periostracum Cicadae 3-6g, Bombyx Batryticatus 5-10g, Folium Perillae 5-10g, Bulbus Fritillariae Thunbergii 1-2g, Radix Glycyrrhizae 3-6g.
Or each crude drug is as follows according to unit of weight proportioning: Folium Eriobotryae 15-20g, Radix Ophiopogonis 15-20g, Radix Adenophorae 10-15g, Folium Mori 10-15g, Semen Armeniacae Amarum 10-15g, Herba Menthae 5-10g, Rhizoma Anemarrhenae 10-15g, Periostracum Cicadae 6-10g, Bombyx Batryticatus 10-15g, Folium Perillae 10-15g, Bulbus Fritillariae Thunbergii 2-4g, Radix Glycyrrhizae 6-10g.
Or each crude drug is as follows according to unit of weight proportioning: Folium Eriobotryae 12-16g, Radix Ophiopogonis 12-16g, Radix Adenophorae 8-12g, Folium Mori 8-12g, Semen Armeniacae Amarum 8-12g, Herba Menthae 4-8g, Rhizoma Anemarrhenae 8-12g, Periostracum Cicadae 4-8g, Bombyx Batryticatus 8-12g, Folium Perillae 8-12g, Bulbus Fritillariae Thunbergii 2-3g, Radix Glycyrrhizae 4-8g.
Goal of the invention to better implement the present invention, the present invention provides again a kind of preparation method for the treatment of the Chinese medicine composition of cough, and wherein, when described Chinese medicine composition is honey refining pill, its preparation method is as follows:
Each crude drug is soaked 30 minutes to 1 hour, and heated and boiled 30 minutes, filters filtrate for later use; Filtering residue adds water, and heating, boils 30 minutes for the second time, refilters filtrate for later use; Filtering residue adds water again, and heated and boiled is 40 minutes for the third time, filters; Three filtrates are combined, and heating is concentrated into pasty state, puts into baking oven, is controlled at 80 ℃, cooling after drying, and mixes and is twisted into slice, pill wax seal packing with Mel;
Or when the dosage form of Chinese medicine composition is capsule, its preparation method is as follows:
The ethanol that each crude drug is added to 10 times of amounts of gross weight, heating and refluxing extraction 3 times, each 2 hours, 3 extracting solution are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/ml, after sucking filtration, when the relative density of filtrate is 20 ℃ 1.08; The adsorption resin column that described filtrate flow is 10L through volume, uses deionized water or the distilled water eluting of 10 times of resin column volumes afterwards, then uses 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove alcohol solvent, obtain component medicated powder, incapsulate and be made as capsule.
Advantage of the present invention is: nourishing YIN to relieve dryness, and dispelling wind and heat pathogens, dispels the wind and gets rid of evils, and medicine source is extensive, harmless, and treatment wind-dryness impairing the lung type cough effect is remarkable, and effective percentage reaches 82.2%, is well 93.5%.
The specific embodiment:
Nourishing YIN to relieve dryness of the present invention, dispelling wind and heat pathogens, dispels the wind and gets rid of evils, and medicine source is extensive, harmless.In the present invention, each crude drug is as follows:
Folium Eriobotryae.Hardship, is slightly cold.< < does not record > >: bitter in the mouth is flat, nontoxic.Return lung, stomach warp.Cure mainly clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI.Cough due to lung-heat, QI rising in reverse order dyspnea with rapid respiration, gastropyretic vomiting, hiccup.
Radix Ophiopogonis, sweet, micro-hardship, is slightly cold.GUIXIN, lung, stomach warp.Sweet cold clear and rich, the heat of the kind lung that clears away heart-fire and yin nourishing relieving restlessness, holding concurrently can clear and rich gastrointestinal and quench the thirst and moisturize.On Antagonizing Experimental Arrhythmia, increase coronary flow.Cough, expectorant due to nourishing the lung to arrest cough treatment dryness-heat impairing the lung are thick, QI rising in reverse order.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough.Chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation; Pharyngeal diphtheria.Control dryness of the lung dry cough, spit blood, spitting of blood, consumptive lung disease, lung abscess, asthenia dysphoria with smothery sensation, quenches one's thirst, calentura Tianjin wound, dry mouth and throat, constipation.
Radix Adenophorae, sweet, cool.Its for the another name ,Zhi Qing Dynasty of Radix Adenophorae (Radix Glehniae) be loaded with Radix Adenophorae (Radix Glehniae) Fen Nan, north two kinds.It is generally acknowledged that two medicine effects are similar, all belong to yin-nourishing drug, there is nourishing YIN and clearing away lung-heat, the effect of reinforcing stomach reg fluid.So Radix Adenophorae claims again large Radix Adenophorae (Radix Glehniae), RADIX ADENOPHORAE, and its shape is thick, and matter is more loose, and effect is poor, and speciality, in entering " lung ", is partial to lung heat clearing away, sputum eliminating cough-relieving; Radix Glehniae, claims again RADIX GLEHNIAE, slice ginseng, and its shape is elongated, the hard density of matter, and effect is better, and speciality is in entering " stomach ", and relatively YIN nourishing and the production of body fluid promoting is quenched the thirst.The present invention adopts Radix Adenophorae.
Folium Mori, sweet in the mouth, hardship; Cold in nature.Return lung, Liver Channel, effect: dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing liver-YANG, liver heat removing and eyesight improving, cooling blood for hemostasis, clearing away lung-heat and moistening for dryness: for lung-heat type cough: this product bitter cold eliminating heat from the lung, sweet cold tonifying YIN, cool lung moistening is dry, therefore can be used for dryness-heat impairing the lung, dry cough is few.
Semen Armeniacae Amarum, lung; Spleen; Large intestine channel.In Semen Armeniacae Amarum, contain amygdaloside, amygdaloside can be hydrolyzed by enteric microorganism enzyme or the contained emulsin of Semen Armeniacae Amarum itself in vivo, produces micro-hydrocyanic acid and benzaldehyde, and respiratory center is had to inhibitory action, reaches antitussive, antiasthmatic effect.
Herba Menthae, pungent, cool.Return liver lung meridian.The effect with dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving, rash, dispersing the stagnated live-QI to relieve the stagnation of QI.Modern medicine is often used it for treatment anemopyretic cold, headache, throat pain, aphtha of the mouth and tongue, rubella, measles, breast abdominal distention is vexed and antiearly pregnancy etc.In addition, Herba Menthae also has anti-inflammatory analgetic effect
The Rhizoma Anemarrhenae, bitter, sweet, cold.Return lung, stomach, kidney channel.Effect and application: 1, clearing away heat-fire---external treatment fever caused by exogenous pathogenic factors, high hot excessive thirst, treatment by oral administration of medicines cough due to lung-heat, gastric heat is quenched one's thirst.2, promote the production of body fluid and moisturize---xeropulmonary cough; Dryness of the intestine constipation; Osteopyrexia and fever.
Periostracum Cicadae, has another name called Periostracum Cicadae, sweet, cold.Return lung, Liver Channel.Function cures mainly: loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.For anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, conjunctival congestion cataracta, convulsion with spasms, tetanus.
Bombyx Batryticatus, acrid in the mouth, salty, property is flat, has expelling wind to relieve convulsion, dissipating phlegm and resolving masses, the effect of heat-clearing and toxic substances removing dampness, is clinically used for controlling heat syndrome cough, and phlegm dyspnea, spits blood, and collapses band, traumatic injury, rheumatalgia, sore etc.
Folium Perillae, pungent, temperature, enters lung meridian, spleen channel, effect: deliver, cold expelling, regulates the flow of vital energy, and battalion.Cure cold, cough, asthma,
Bulbus Fritillariae Thunbergii, the positive > > of < < book on Chinese herbal medicine: the large hardship of taste, cold in nature.Removing heat-phlegm, powder detoxifcation.
Radix Glycyrrhizae, Radix Glycyrrhizae property is flat, and sweet in the mouth, returns 12 warps.Have removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic be so that the pharmacological action such as anticancer.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.The present invention adopts Radix Glycyrrhizae, and it removes impurity for crude drug, cleans, and runs through section, raw with being used as medicine, relatively heat-clearing and toxic substances removing.
Prescription of the present invention is configured to according to unit of weight: Folium Eriobotryae 10-20g, Radix Ophiopogonis 10-20g, Radix Adenophorae 5-15g, Folium Mori 5-15g, Semen Armeniacae Amarum 5-15g, Herba Menthae 3-10g, Rhizoma Anemarrhenae 5-15g, Periostracum Cicadae 3-10g, Bombyx Batryticatus 5-15g, Folium Perillae 5-15g, Bulbus Fritillariae Thunbergii 1-4g, Radix Glycyrrhizae 3-10g.
Or, Folium Eriobotryae 10-15g, Radix Ophiopogonis 10-15g, Radix Adenophorae 5-10g, Folium Mori 5-10g, Semen Armeniacae Amarum 5-10g, Herba Menthae 3-5g, Rhizoma Anemarrhenae 5-10g, Periostracum Cicadae 3-6g, Bombyx Batryticatus 5-10g, Folium Perillae 5-10g, Bulbus Fritillariae Thunbergii 1-2g, Radix Glycyrrhizae 3-6g.
Or, Folium Eriobotryae 15-20g, Radix Ophiopogonis 15-20g, Radix Adenophorae 10-15g, Folium Mori 10-15g, Semen Armeniacae Amarum 10-15g, Herba Menthae 5-10g, Rhizoma Anemarrhenae 10-15g, Periostracum Cicadae 6-10g, Bombyx Batryticatus 10-15g, Folium Perillae 10-15g, Bulbus Fritillariae Thunbergii 2-4g, Radix Glycyrrhizae 6-10g.
Or, Folium Eriobotryae 12-16g, Radix Ophiopogonis 12-16g, Radix Adenophorae 8-12g, Folium Mori 8-12g, Semen Armeniacae Amarum 8-12g, Herba Menthae 4-8g, Rhizoma Anemarrhenae 8-12g, Periostracum Cicadae 4-8g, Bombyx Batryticatus 8-12g, Folium Perillae 8-12g, Bulbus Fritillariae Thunbergii 2-3g, Radix Glycyrrhizae 4-8g.
The present invention treats the preparation method of the Chinese medicine composition of cough, during preparation honey refining pill, each crude drug is soaked 30 minutes to 1 hour, and heated and boiled 30 minutes, filters filtrate for later use; Filtering residue adds water, and heating, boils 30 minutes for the second time, refilters filtrate for later use; Filtering residue adds water again, and heated and boiled is 40 minutes for the third time, filters; Three filtrates are combined, and heating is concentrated into pasty state, puts into baking oven, is controlled at 80 ℃, cooling after drying, and mixes and is twisted into slice, pill wax seal packing with Mel;
Or, while preparing capsule: each crude drug is added to the ethanol of 10 times of amounts of gross weight, heating and refluxing extraction 3 times, each 2 hours, 3 extracting solution are merged to decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/ml, after sucking filtration, when the relative density of filtrate is 20 ℃ 1.08; The adsorption resin column that described filtrate flow is 10L through volume, uses deionized water or the distilled water eluting of 10 times of resin column volumes afterwards, then uses 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove alcohol solvent, obtain component medicated powder, incapsulate and be made as capsule.
Concrete example is as follows
Embodiment 1
Liu, 27 years old, man, autumn is when see and treat patients, patient's dry cough, without expectorant or there is a small amount of sticky expectorant, is difficult for bringing up, and is diagnosed as the cough of wind-dryness impairing the lung type, use following prescription: Folium Eriobotryae 20g, Radix Ophiopogonis 20g, Radix Adenophorae 15g, Folium Mori 15g, Semen Armeniacae Amarum 15g, Herba Menthae 10g, Rhizoma Anemarrhenae 15g, Periostracum Cicadae 10g, Bombyx Batryticatus 15g, Folium Perillae 15g, Bulbus Fritillariae Thunbergii 4g, Radix Glycyrrhizae 10g.Be decocted in water for oral dose, every day is each potion sooner or later.After above-mentioned medicament is taken after 7 days, symptom recovery from illness, visits after two months, without recurrence.
Embodiment 2
Mrs Lu, 32 years old, while seeing and treating patients, dry cough, did and choked repeatedly spring, itching of the throat, pharyngodynia with dryness, lip xeromycteria, without expectorant, xerostomia is followed nasal obstruction, headache fever of the body.Diagnosing it is the cough of wind-dryness impairing the lung type, uses following prescription.Folium Eriobotryae 15g, Radix Ophiopogonis 15g, Radix Adenophorae, each 10g of Folium Mori, Semen Armeniacae Amarum 10g, Herba Menthae 5g, Rhizoma Anemarrhenae 10g, Periostracum Cicadae 6g, Bombyx Batryticatus 10g, Folium Perillae 10g, Bulbus Fritillariae Thunbergii 2g, Radix Glycyrrhizae 6g.Be decocted in water for oral dose, every day is each potion sooner or later.Above-mentioned medicament is taken after 12 doses, and symptom alleviates, and continuous takes 6 doses, and recovery from illness is visited after after half a year, without recurrence.
Embodiment 3
Zhang, man.36 years old, the symptom of seeing and treating patients was: dry cough, and lip xeromycteria, nasal obstruction, headache, red tongue, white and thin fur or BOHUANG, do and few Tianjin floating and rapid pulse.Be diagnosed as wind-dryness impairing the lung type cough, use following prescription: Folium Eriobotryae 10g, Radix Ophiopogonis 10g, Radix Adenophorae 5g, Folium Mori 5g, Semen Armeniacae Amarum 5g, Herba Menthae 3g, Rhizoma Anemarrhenae 5g, Periostracum Cicadae 3g, Bombyx Batryticatus 5g, Folium Perillae 5g, Bulbus Fritillariae Thunbergii 1g, Radix Glycyrrhizae 3g.Be decocted in water for oral dose, every day is each potion sooner or later.Above-mentioned medicament is taken after 8 doses, and symptom alleviates, and continuous takes 6 doses, and recovery from illness is visited after after half a year, without recurrence.
Embodiment 4, Mr. Huang, and 32 years old, dry cough, expectorant is few and glutinous, sputum with blood streaks, yellow and thin fur, nasal obstruction is followed headache.Be diagnosed as wind-dryness impairing the lung type cough, use following prescription: Folium Eriobotryae 12g, Radix Ophiopogonis 12g, Radix Adenophorae 8g, Folium Mori 8g, Semen Armeniacae Amarum 8g, Herba Menthae 4g, Rhizoma Anemarrhenae 8g, Periostracum Cicadae 4g, Bombyx Batryticatus 8g, Folium Perillae 8g, Bulbus Fritillariae Thunbergii 2g, Radix Glycyrrhizae 4g.Be decocted in water for oral dose, every day is each potion sooner or later.Above-mentioned medicament is taken after 10 doses, and symptom alleviates, and continuous takes 6 doses, and recovery from illness is visited after after half a year, without recurrence.
Nourishing YIN to relieve dryness of the present invention, dispelling wind and heat pathogens, dispels the wind and gets rid of evils, and medicine source is extensive, harmless, and treatment wind-dryness impairing the lung type cough effect is remarkable, and effective percentage reaches 82.2%, is well 93.5%.