A kind of Fructus Perillae a kind of reed mentioned in ancient books Fructus Pruni decoction for the treatment of asthma and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine for the treatment of asthma.
Background technology
Asthma, claims again asthma, is a kind of chronic airway inflammation disease that reversible airflow limitation is feature of take.If inflammation can not get effective control for a long time, can there is Airway Remodeling, cause irreversibility air flue constriction.
At present, the pathologic data of relevant asthma is mostly from the corpse of dying from the patient of asthma, and the biopsy specimen of common asthmatic patient.Dissimilar asthma (as: allergic asthma, intrinsic asthma, occupational asthma, aspirin asthma, childhood asthma etc.), its pathological change is basically identical.Substantially see: atelectasis, visible mucus bolt (can have purulent exudate during concurrent infection) in bronchial lumen, bronchial wall edema, thickens.The visible pulmonary atelectasis in mucus bolt thromboembolism place.The pathological changes of asthma is dispersed throughout whole air flue, but does not involve interstitial lung; Asthma is more serious, and small airway inflammation is more obvious.Pathological changes can be kitchen range and distribute, the inhomogeneities of visible airway constriction under bronchoscope.
The medicine for the treatment of asthma can be divided into " control outbreak medicine " (controller) and " alleviating outbreak medicine " (reliever).Controlling outbreak medical instrument has antiinflammatory action, also claims " anti-inflammatory agent ", after rule application, can control chronic airway inflammation, reduces and even avoids asthma in acute attack, and Control of asthma development, stablizes pulmonary function.Alleviating outbreak medical instrument has bronchorelaxing activity, therefore, also claims " bronchodilatation medicine ", normally when asthma in acute attack, uses as required.
Summary of the invention
The object of the present invention is to provide a kind of Fructus Perillae a kind of reed mentioned in ancient books Fructus Pruni decoction for the treatment of asthma and preparation method thereof, simultaneously using both cold and hot drugs, table reason is ruled together.
The technical scheme that the present invention takes is:
Treat Fructus Perillae a kind of reed mentioned in ancient books Fructus Pruni decoction of asthma, by the crude drug of following weight part ratio, made: Fructus Perillae 15-20 part, Semen Armeniacae Amarum 10-12 part, Radix Scutellariae 12-15 part, Semen Lepidii (Semen Descurainiae) 15-18 part, Pheretima 10-13 part, Radix Peucedani 12-15 part, Herba Houttuyniae 15-20 part, Flos Lonicerae 15-20 part, Cortex Mori 12-15 part, Radix Asteris 10-13 part, Flos Farfarae 12-15 part, Radix Glycyrrhizae 5-12 part.
Fructus Perillae a kind of reed mentioned in ancient books Fructus Pruni decoction of described treatment asthma, is preferably made by the crude drug of following weight part ratio: 15 parts of Fructus Perillaes, 10 parts, Semen Armeniacae Amarum, 12 parts of Radix Scutellariaes, 15 parts of Semen Lepidii (Semen Descurainiae)s, 10 parts of Pheretimas, 12 parts of Radix Peucedanis, 15 parts of Herba Houttuyniae, 15 parts of Flos Loniceraes, 12 parts of Cortex Mori, 10 parts of Radix Asteriss, 12 parts of Flos Farfaraes, 8 parts, Radix Glycyrrhizae.
The preparation method of Fructus Perillae a kind of reed mentioned in ancient books Fructus Pruni decoction of described treatment asthma is:
Add its gross mass 8-20 decocting doubly to boil each crude drug, decoct 2-3 time, each half an hour, collecting decoction.
Fructus Perillae is pungent, temperature.Return lung meridian.Sending down the abnormal ascending QI expectorant, relievings asthma, intestine moistening.
Semen Armeniacae Amarum is bitter, tepor; Slightly poisonous, relieving cough and asthma, loosening bowel to relieve constipation.
Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, jaundice due to damp-heat, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.
Semen Lepidii (Semen Descurainiae) nature and flavor are pungent, temperature.Warming the lung eliminating phlegm promoting the circulation of QI, resolving mass and removing the obstruction of the collateral pain relieving.For cold-phlegm, breath with cough, distending pain in the chest and hypochondrium, the stagnant meridians of expectorant, joint numbness, pain, phlegm-damp oozing in the body, carbuncle of yin nature toxic swelling.
Pheretima has: diuresis, ease pain, relieving asthma, the effect such as blood pressure lowering, antipyretic, convulsion.
Radix Peucedani dispelling wind and heat pathogens; Lowering the adverse-rising QI to resolve phlegm.Main affection due to external wind and heat; Lung-heat phlegm stagnancy; Cough with asthma abundant expectoration; Expectorant Huang is sticky; Contrary lack of appetite; Chest and diaphragm is full vexed.For cough due to pathogenic wind-heat's abundant expectoration, expectorant dyspnea of heat type is full, coughs up phlegm yellow thick.
Herba Houttuyniae enters liver, lung two warps.Heat-clearing and toxic substances removing; Removing pus and relieving carbuncle; Inducing diuresis for treating stranguria syndrome.
Flos Lonicerae is described as the good medicine of heat-clearing and toxic substances removing from ancient times.The sweet cold of its property fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, and kind removing summer-heat blood poison also, for various febrile diseases.
Cortex Mori eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.For lung-heat cough with asthma, the edema of the face, the diseases such as dysuria.
Radix Asteris is root and the rhizome of feverfew Radix Asteris, property of medicine bitter in the mouth; Pungent; Warm in nature, return lung meridian, there is the effect of nourishing the lung to keep the adverse QI downward, preventing phlegm from forming and stopping coughing.
Flos Farfarae is coltsfoot, and coltsfoot is the alabastrum of Compositae coltsfoot, and property and flavor of peppery and warm, has nourishing the lung to keep the adverse QI downward, the effect of the antitussive that reduces phlegm.In < < herbal classic > >, record: to " pathogenic fluid-retention of cold bundle lung meridian is breathed heavily, coughs the most suitable ".Though abnormal smells from the patient is warm, embellish but not dry, warm heresy, strongly fragrant in lung meridian and must not catharsis person, also can control it.Therefore the cough of Exogenous and internal injuries, cold and heat and asthenia and sthenia, all can apply.Particularly chronic cough of deficiency lung is more than, the most applicable.
The effect of Radix Glycyrrhizae has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The pungent temperature lung qi dispersing of prescription Fructus Perillae of the present invention, makes lung qi unobstructed, joins Semen Armeniacae Amarum Radix Glycyrrhizae, and Xin Wen is loose evil, relieving cough and asthma; Radix Scutellariae bitter cold, clearing heat and purging lung; Pheretima is salty-cold, and lung heat clearing spasmolytic makes airway patency rush down phlegm retention; Radix Peucedani removing heat-phlegm, inducing diaphoresis to expel pathogens; Herba Houttuyniae, Cortex Mori eliminating phlegm; Radix Asteris, Flos Farfarae are cough-relieving good medicine, jointly form removing heat-phlegm, lung qi dispersing spasmolytic, the prescription of relieving cough and asthma.We's compatibility, simultaneously using both cold and hot drugs, table reason is ruled together, and clinical practice face is wider.Use Drug therapy asthma patient 50 examples of the present invention, effective 40 examples, effective 6 examples, invalid 4 examples.
The specific embodiment
Below in conjunction with specific embodiment, further illustrate.
Embodiment 1
Fructus Perillae a kind of reed mentioned in ancient books Fructus Pruni decoction for the treatment of asthma, is made by the crude drug of following weight part ratio: 15 grams of Fructus Perillaes, 10 grams, Semen Armeniacae Amarum, 12 grams of Radix Scutellariaes, 15 grams of Semen Lepidii (Semen Descurainiae)s, 10 grams of Pheretimas, 12 grams of Radix Peucedanis, 15 grams of Herba Houttuyniae, 15 grams of Flos Loniceraes, 12 grams of Cortex Mori, 10 grams of Radix Asteriss, 12 grams of Flos Farfaraes, 8 grams, Radix Glycyrrhizae.
Preparation method:
Add the decocting of 8 times of its gross masses to boil each crude drug, decoct 3 times, each half an hour, collecting decoction.
Embodiment 2
Treat Fructus Perillae a kind of reed mentioned in ancient books Fructus Pruni decoction of asthma, by the crude drug of following weight part ratio, made: 20 grams of Fructus Perillaes, 12 grams, Semen Armeniacae Amarum, 15 grams of Radix Scutellariaes, 18 grams of Semen Lepidii (Semen Descurainiae)s, 13 grams of Pheretimas, 15 grams of Radix Peucedanis, 20 grams of Herba Houttuyniae, 20 grams of Flos Loniceraes, 15 grams of Cortex Mori, 13 grams of Radix Asteriss, 15 grams of Flos Farfaraes, 12 grams, Radix Glycyrrhizae.
Each crude drug adds the decocting of 10 times of its gross masses to boil, and decocts 3 times, each half an hour, collecting decoction.
Embodiment 3
Treat Fructus Perillae a kind of reed mentioned in ancient books Fructus Pruni decoction of asthma, by the crude drug of following weight part ratio, made: 18 grams of Fructus Perillaes, 11 grams, Semen Armeniacae Amarum, 13 grams of Radix Scutellariaes, 17 grams of Semen Lepidii (Semen Descurainiae)s, 12 grams of Pheretimas, 13 grams of Radix Peucedanis, 18 grams of Herba Houttuyniae, 18 grams of Flos Loniceraes, 13 grams of Cortex Mori, 12 grams of Radix Asteriss, 13 grams of Flos Farfaraes, 5 grams, Radix Glycyrrhizae.
Each crude drug adds the decocting of 15 times of its gross masses to boil, and decocts 2-time, each half an hour, collecting decoction.
Clinical trial:
Choose the symptom of case:
1. repeatedly show effect dyspnea, wheezing due to retention of sputum in the throat, with cough uncomfortable in chest.
2. two lung audibles and diffusivity wheezing sound while showing effect, obvious during especially with expiration.
3. rabat: the bright degree of two lungs increases, enhanced lung markings.
Treatment or instructions of taking: with the medicine of embodiment 1, be potion, every dose one day, three times on the one.
The standard of curative effect evaluation:
Effective: the symptom of panting and pulmonary's wheezing sound are clearly better.
Effective: the symptom of panting and pulmonary's wheezing sound take a favorable turn.
Invalid: the symptom of panting and pulmonary's wheezing sound are without taking a turn for the better or increasing the weight of.
Model case has:
1, Zhu, man, 40 years old, heating over these days, cough, subtracts through treating heat, and cough exacerbates, asthma rale, nausea and vomiting, thirsty polydipsia, loss of appetite, sweating, large dry stool, red tongue with thin and yellow fur.Above application, after five doses, rale is removed, and heat is moved back, and three doses of diseases are removed again.
2, Lin, female, 30 years old, onset two days, the cough of heating slight perspiration is rough, and flaring of nares is thirsty vexed, lassitude, the micro-Huang of red tongue tongue, five doses of clothes medicine-feedings, recovery from illness.
3. female, 23 years old, there is suddenly dyspnea after fish and shrimp in the time of 6 years old in patient on the feed, and whistling sound in the throat can not be put down sleepingly, through treatment, alleviates.Afterwards often because of improper diet or suffer from cold and show effect, can not spontaneous remission.Because of tired, suffering from cold there is dyspnea, whistling sound in the throat, rale is as shouted, rapid breathing is uncomfortable in chest, time have cough, the thin color of thin sputum is white, difficulty in expectorating, dark and greenish complexion, thirsty desire for hot drinks, headache, white and slippery fur, stringy and tense pulse or floating tight.Have a medical check-up: T:36.5 ℃, P:90 beat/min, R:22 beat/min, BP:120/80mmHg. nutrition is impartial, grows normally, and two pulmonary respiration sounds are thick, are abound with wheezing sound, obvious during especially with expiration.Heart no abnormality seen.Breast abdomen dyskinesis.With wheezing behind five doses of tops, remove, heat is moved back, and five doses of diseases are removed again.