CN102746676B - Gelatin pearl hollow capsule and preparation method of gelatin pearl hollow capsule - Google Patents
Gelatin pearl hollow capsule and preparation method of gelatin pearl hollow capsule Download PDFInfo
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- CN102746676B CN102746676B CN201210241613.5A CN201210241613A CN102746676B CN 102746676 B CN102746676 B CN 102746676B CN 201210241613 A CN201210241613 A CN 201210241613A CN 102746676 B CN102746676 B CN 102746676B
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- pearly
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- lustre
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Abstract
The invention provides a gelatin pearl hollow capsule and a preparation method of the gelatin pearl hollow capsule. The problem that a safe capsule which is applicable to high-grade medicine and health care products and has the pearly color is lacked in the prior part can be solved. On the one hand, the invention provides the gelatin pearl hollow capsule, which comprises pearl pigment accounting for 0.005 to 1 percent of the total weight of the capsule, and the pearl pigment is a compound of nanoscale titanium dioxide and potassium aluminium silicate, wherein the weight percent of the nanoscale titanium dioxide is 30 to 50 percent, and the weight percent of the nanoscale titanium dioxide is 50 to 70 percent. The invention also provides the preparation method of the gelatin pearl hollow capsule. Through the addition of medicinal allowed auxiliary materials and the adoption of special processing processes, the capsule with the pearly color is produced, and the market requirements are met.
Description
Technical field
The present invention relates to medical capsule field, specifically, is a kind of gelatin pearly-lustre Capsules and preparation method thereof.
Background technology
Capsules usually reaches certain appearance colour by adding natural pigment and combination colour, makes people increase the stimulation on sense organ in using capsule, but does not see the capsule with the general charming color of pearly-lustre always.Due to its special needs, for example, on healthcare products and high-grade medicine, need capsule to there is high glossiness and brightness, add less again pigment simultaneously, improve the security of capsule.
Summary of the invention
The invention provides a kind of gelatin pearly-lustre Capsules and preparation method thereof, what can solve that prior art exists lacks a kind of adaptation on high-grade medicine and healthcare products, with the problem of the safety capsule of pearly-lustre color.
For solving the problems of the technologies described above, on the one hand, the invention provides a kind of gelatin pearly-lustre Capsules, described capsule contains 0.005～1% the pearly pigment that accounts for capsule gross weight, described pearly pigment is the mixture of nano grade titanium white powder and aluminum potassium silicate, wherein the weight percent of titanium dioxide is 30～50%, and the weight percent of aluminum potassium silicate is 50～70%.
Wherein, the mass percent formula of described gelatin pearly-lustre Capsules is as follows: gelatin 82.47～87.79%, sodium lauryl sulphate 0.05～0.3%, polyoxyethylene glycol 0.01～0.2%, pigment 0.01～0.02%, pearly pigment 0.005～1%, all the other are moisture.
Wherein, the size range of described pearly pigment: 5～30 μ m.
Wherein, described pigment comprises synthetic colour, natural pigment.
On the other hand, the present invention also provides a kind of preparation method of gelatin pearly-lustre Capsules,
Wherein, the formula of described gelatin pearly-lustre Capsules is as follows: gelatin 82.47%～87.79%, and sodium lauryl sulphate 0.05%～0.3%, polyoxyethylene glycol 0.01%～0.2%, pigment 0.01～0.02%, pearly pigment 0.005～1%, all the other are moisture;
Concrete preparation process is as follows:
(1) preparation pearly pigment solution: the hot deionized water that adds in advance 90 DEG C～100 DEG C in container, add part polyoxyethylene glycol, the quality percentage composition that makes polyoxyethylene glycol is 0.1%～0.5%, be stirred to and dissolve completely and stir, add pearly pigment, make pearly pigment mass percent 5～15%, limit edged stirs, and adds rear continuation to stir clockwise 2-4 hour to obtain pearly pigment solution completely;
(2) prepare main glue: by gelatin, sodium lauryl sulphate in formula, that residue polyoxyethylene glycol components dissolved is made into main glue is stand-by;
(3) the main glue preparing is stirred clockwise, measure corresponding pearly pigment solution according to formula and join in main glue, same maintenance stirs clockwise, and then adds the pigment of formula ratio, be adjusted to the tone needing, leave standstill and stablize to 50～55 DEG C;
(4) by the glue of having stablized, use capsule manufacture machine to carry out full-automation and produce, can produce the gelatin pearly-lustre Capsules that conformance with standard requires.
Wherein, in step (1), in whipping process, open homogenizer, in whipping process, keep temperature all the time more than 60 DEG C, speed is 2000～5000 revs/min, pearly pigment is fully distributed in glue, in the process that can avoid producing, there is the phenomenons such as painted inhomogeneous and layering and precipitating, make the capsule pearly-lustre look soft produced evenly.
Pearly pigment used in the present invention, by a kind of mixture that forms by nano grade titanium white powder and aluminum potassium silicate, meets European Pharmacopoeia E171 and E555, the outside of aluminum potassium silicate coated titanium white powder wherein.
The present invention can, according to the bright degree of pearly-lustre look, select capable being used in conjunction with of pearly pigment of different-grain diameter.If desired glossiness is high, by larger the selection of particle diameter, relatively low if glossiness is selected, and selects particle diameter little, carries out proportioning.
According to the difference of pearly-lustre look, use different pigments and the above-mentioned pearly pigment of handling well to be used in conjunction with, can produce respectively and there is versicolor pearly-lustre Capsules.
Specify according to pharmacopeia: the addition of the pearly pigment in the present invention's formula must not exceed 1.25%.Content in visible formula meets pharmacopeia regulation.
Gelatin pearly-lustre Capsules of the present invention is adapted to the production of machine-processed hollow capsule production line, the present invention is a kind of novel empty hard capsule, making capsule have the color and luster that pearl is general, broken through the color and luster that common synthetic colour, natural pigment etc. produce, is a kind of capsule with special color and luster.
Be adapted to gelatin be the Capsules that main raw is made.
Compared with prior art, the present invention has the following advantages and positively effect:
The present invention is by adding the auxiliary material of medicinal permission and special complete processing, produce the capsule with pearly-lustre color, adapt on high-grade medicine and healthcare products, and the pearly pigment adding meets the requirements completely, under the prerequisite of magnificent color that ensures to meet high-grade medicine, improve capsule security.
Embodiment
Below in conjunction with examples of implementation, the present invention is described in further detail.
Embodiment 1
Take 5 parts of polyoxyethylene glycol, join in 1000 parts 95 DEG C above hot purified water, open homogenizer, speed control is at 5000 revs/min, is stirred to completely and dissolves, and takes particle diameter and be 100 parts of the pearly pigments of 10～18 μ m, join in the above-mentioned aqueous solution, limit edged stirs, and after all adding, continues to stir 2 hours.Get 1000 parts of solvent gelatin glues, open and stir, add 100 parts of the above-mentioned pearly-lustre solution preparing, just stir and just add, add the carmine synthetic colour that waits a small amount of, colorimetric simultaneously, adjust to the tone needing, stablize more than 2 hours at 50 DEG C, upper capsule manufacture machine is produced, and obtains gelatin pearly-lustre Capsules.
Embodiment 2
Take 10 parts of polyoxyethylene glycol, join in 1000 parts 95 DEG C above hot purified water, open homogenizer, speed control is at 5000 revs/min, is stirred to completely and dissolves, and takes particle diameter and be 50 parts of the pearly pigments of 15～20 μ m and particle diameter and be 50 parts of the pearly pigments of 20～30 μ m, join in the above-mentioned aqueous solution, limit edged stirs, and after all adding, continues to stir 4 hours.Get 1000 parts of solvent gelatin glues, open and stir, add 100 parts of the above-mentioned pearly-lustre solution preparing, just stir and just add, add simultaneously and brightly blue wait that synthetic colour is a small amount of, titanium dioxide pink colour element is a small amount of, colorimetric, adjust to the tone needing, stablize more than 2 hours at 50 DEG C, upper capsule manufacture machine is produced, and obtains gelatin pearly-lustre Capsules.
Embodiment 3
Take 5 parts of polyoxyethylene glycol, join in 1000 parts 95 DEG C above hot purified water, open homogenizer, speed control is at 5000 revs/min, is stirred to completely and dissolves, and takes particle diameter and be 30 parts of the pearly pigments of 10～18 μ m and particle diameter and be 70 parts of the pearly pigments of 20～30 μ m, join in the above-mentioned aqueous solution, limit edged stirs, and after all adding, continues to stir 4 hours.Get 1000 parts of solvent gelatin glues, open and stir, add 100 parts of the above-mentioned pearly-lustre solution preparing, just stir and just add, add that the synthetic colours such as lemon yellow are a small amount of, titanium dioxide pink colour element is a small amount of, colorimetric simultaneously, adjust to the tone needing, stablize more than 2 hours at 50 DEG C, upper capsule manufacture machine is produced, and obtains gelatin pearly-lustre Capsules.
The gelatin pearly-lustre Capsules indices of producing should meet following quality standard: the standard-required of " Chinese Pharmacopoeia " version gelatin Capsules in 2010.
The above, be only preferred embodiment of the present invention, is not the restriction of the present invention being made to other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (1)
1. a preparation method for gelatin pearly-lustre Capsules, is characterized in that:
The mass percent formula of described gelatin pearly-lustre Capsules is as follows: gelatin 82.47%～87.79%, and sodium lauryl sulphate 0.05%～0.3%, polyoxyethylene glycol 0.01%～0.2%, pigment 0.01～0.02%, pearly pigment 0.005～1%, all the other are moisture; Described pearly pigment is the mixture of nano grade titanium white powder and aluminum potassium silicate, and wherein to account for the weight percent of pearly pigment be 30～50% to titanium dioxide, and the weight percent that aluminum potassium silicate accounts for pearly pigment is 50～70%;
Concrete preparation process is as follows:
(1) preparation pearly pigment solution: the hot purified water that adds in advance 90 DEG C～100 DEG C in container, add part polyoxyethylene glycol, the quality percentage composition that makes polyoxyethylene glycol is 0.1%～0.5%, be stirred to and dissolve completely and stir, add pearly pigment, make pearly pigment mass percent 5～15%, limit edged stirs, in whipping process, open homogenizer, in whipping process, keep temperature all the time more than 60 DEG C, speed is 2000～5000 revs/min, adds rear continuation to stir clockwise 2-4 hour to obtain pearly pigment solution completely;
(2) prepare main glue: by gelatin, sodium lauryl sulphate in formula, that residue polyoxyethylene glycol components dissolved is made into main glue is stand-by;
(3) the main glue preparing is stirred clockwise, measure corresponding pearly pigment solution join in main glue according to formula, same maintenance stirs clockwise, and then adds the pigment of formula ratio, is adjusted to the tone needing, and leaves standstill and stablizes to 50～55 DEG C;
(4) by the glue of having stablized, use capsule manufacture machine to carry out full-automation and produce, can produce the gelatin pearly-lustre Capsules that conformance with standard requires;
The gelatin pearly-lustre Capsules indices of producing meets the standard-required of " Chinese Pharmacopoeia " version gelatin Capsules in 2010.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210241613.5A CN102746676B (en) | 2012-07-12 | 2012-07-12 | Gelatin pearl hollow capsule and preparation method of gelatin pearl hollow capsule |
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| CN201210241613.5A CN102746676B (en) | 2012-07-12 | 2012-07-12 | Gelatin pearl hollow capsule and preparation method of gelatin pearl hollow capsule |
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| CN102746676A CN102746676A (en) | 2012-10-24 |
| CN102746676B true CN102746676B (en) | 2014-12-03 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP6689845B2 (en) * | 2015-07-01 | 2020-04-28 | 株式会社クラレ | Manufacturing method of resin plate with pearl pattern, and manufacturing method of molded product |
| CN105079813A (en) * | 2015-08-17 | 2015-11-25 | 江苏力凡胶囊有限公司 | Method for preparing empty capsule containing pearlescent pigment through coating method |
| CN105534944A (en) * | 2015-12-31 | 2016-05-04 | 广东国方医药科技有限公司 | Nano TiO2-containing vacant capsules and preparation method thereof |
| CN105853390A (en) * | 2016-05-20 | 2016-08-17 | 夏放军 | Natural harmless hollow capsules and preparation method thereof |
| CN113244186A (en) * | 2021-05-13 | 2021-08-13 | 青岛益青生物科技股份有限公司 | Enteric gelatin hollow capsule with new formula and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1951500A (en) * | 1998-07-16 | 2007-04-25 | 默克专利股份有限公司 | Colouring application of pearly pigment in medicine |
| CN102525995A (en) * | 2011-12-23 | 2012-07-04 | 湖北人福康华药用辅料有限公司 | Plant officinal hollow capsule and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6627212B2 (en) * | 2001-06-26 | 2003-09-30 | Engelhard Corporation | Use of effect pigments in ingested drugs |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1951500A (en) * | 1998-07-16 | 2007-04-25 | 默克专利股份有限公司 | Colouring application of pearly pigment in medicine |
| CN102525995A (en) * | 2011-12-23 | 2012-07-04 | 湖北人福康华药用辅料有限公司 | Plant officinal hollow capsule and preparation method thereof |
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Address after: 266111 Shandong city of Qingdao province Chengyang Jihongtan Street Green Industrial Park No. 17 South Road Patentee after: Qingdao Yiqing biological Polytron Technologies Inc Address before: 266111 Shandong city of Qingdao province Chengyang Jihongtan Street Green Industrial Park No. 17 South Road Patentee before: Qingdao Yiqing Medical Capsules Co., Ltd. |
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