CN105534944A - Nano TiO2-containing vacant capsules and preparation method thereof - Google Patents
Nano TiO2-containing vacant capsules and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
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Abstract
The invention relates to the technical field of vacant capsules and particularly relates to nano TiO2-containing vacant capsules and a preparation method thereof. The nano TiO2-containing vacant capsules consist of the following raw materials in parts by weight: 50-60 parts of main ingredient, 2-8 parts of plasticizer, 2-8 parts of tween-80, 15-25 parts of titanium dioxide, 3-8 parts of pigment, 2-10 parts of nano TiO2 and 30-40 parts of water, wherein the main ingredient refers to one or both of gelatin and hydroxypropyl methyl cellulose; and the plasticizer refers to one or both of glycerin and polyethylene glycol. According to the preparation method of the vacant capsules provided by the invention, the technology is simple, the moisture of the vacant capsules is controlled at 10-18%, and the prepared vacant capsules have anti-ultraviolet and anti-color change properties as well as a self-antibacterial function while the storage life is long.
Description
Technical field
The present invention relates to Capsules technical field, be specifically related to a kind of containing nano-TiO
2capsules and preparation method thereof.
Background technology
In prior art, capsule has the features such as bioavailability is high, good airproof performance, medicine stability are good, content is accurate, good looking appearance compared with other dosage forms, it is used for water-insoluble or the water soluble drug of some character instability (as photaesthesia, oxidizable or volatilization, meeting damp and hot instability etc.) and has the medicine of poor taste, abnormal smells from the patient, can play the effect increasing stability, improve bioavailability and taste masking.
Existing capsule is capsule material mainly with gelatin, take glycerol as plasticizer, due to the character of gelatin self, and the high-permeability of glycerol, also there are some stability problems in capsule, as in storage period, disintegrate is defective, there is the phenomenons such as material transport in capsule, formulation development is encountered difficulties.
Research finds that strong ultraviolet or radiation of visible light can accelerate gelatin change, causes dissolution rate in vitro to reduce, and as while illumination, humidity is higher, and when gelatine capsule contains orchil, this impact is especially remarkable.Many dyestuffs can with gelatin by hydrophobic bond and hydrogen bonded, therefore existing capsule is preferably stored under lucifuge condition, does not use colouring substance when there is no need as far as possible.In addition, traditional capsule does not have from antibacterial functions, and the storage life of capsule is considerably reduced.
Summary of the invention
The object of the invention is for above-mentioned deficiency of the prior art, provide a kind of containing nano-TiO
2capsules, it has uvioresistant Anti-tarnish property and from antibacterial functions, long shelf-life.
The object of the invention is for above-mentioned deficiency of the prior art, provide a kind of containing nano-TiO
2the preparation method of Capsules, technique is simple, Capsules moisture Control between 10-18%, can significantly improve Capsules uvioresistant Anti-tarnishing function and from antibacterial functions.
Object of the present invention is achieved through the following technical solutions.
A kind of containing nano-TiO
2capsules, be made up of the raw material of following weight portion:
Major ingredient 50-60 part
Plasticizer 2-8 part
Tween 80 2-8 part
Titanium dioxide 15-25 part
Pigment 3-8 part
Nano-TiO
22-10 part
Water 30-40 part
Wherein, described major ingredient is one or both in gelatin, hydroxypropyl emthylcellulose;
Wherein, described plasticizer is one or both in glycerol, Polyethylene Glycol.
Preferably, the mixture of described major ingredient to be gelatin, hydroxypropyl emthylcellulose with mass ratio be 2-3:1; Preferably, the mixture of described plasticizer to be glycerol, Polyethylene Glycol with mass ratio be 2-3:1-1.5.
Titanium dioxide of the present invention is for being Rutile type titanium dioxide, and its whiteness L-value is greater than 97, B values and is less than 0, and particle diameter is less than 4 microns.The shading of Rutile type titanium dioxide, weatherability, gloss retention, tinting strength, tinting power excellence, the good weatherability of obtained Capsules, shading performance is good.Particularly, the particle diameter of described Rutile type titanium dioxide is 3.25 microns, whiteness 99, is that the trade mark of German Kang Nuosi international corporation production is the product of K2233.
Preferably, a kind of containing nano-TiO
2capsules, be made up of the raw material of following weight portion:
Major ingredient 50-55 part
Plasticizer 3-5 part
Tween 80 3-5 part
Titanium dioxide 15-20 part
Pigment 3-5 part
Nano-TiO
22-5 part
Water 30-40 part.
Wherein, described nano-TiO
2particle diameter be 50-100nm.
Wherein, described pigment is at least one in light blue, lemon yellow, ferrum oxide.
Wherein, the amino acid whose content in the described gelatin Central Asia is the 10-20% of gelatin gross mass.
Gelation is the most important functional character of gelatin, it refers to that gelatin molecule reverts to orderly triple-helix structure gradually by random coil state under certain condition, this process mainly divides three phases: first, when temperature be down to freezing point about (35 DEG C) below time, in gelatin solution, the polypeptide chain of random coil revolves into left hand helix again, between adjacent left hand helix segment, effect produces hydrogen bond crosslinks, and again form the nucleus of class collagen helix body, this process is called " renaturation "; The second, the polymerization of class collagen helix body forms microgel; 3rd, aggregation forms the network gel with certain rigidity further.
Class triple-helix structure in gelatin gel mainly maintains by oxygen key in molecule and the hydration of oxygen key, and-the NH of the Pro in the imino acid ,-OH of Hyp all can form oxygen key with other amino acid side groups and hydrone, is beneficial to the stable of class triple-helix structure.Imino acid content of the present invention is up to 10-20%, and the gelling performance of gelatin is superior, and the gelation of colloidal sol is good, the stable performance of obtained Capsules.
Wherein, the molecular weight of described gelatin is 20000 ~ 250000Da, and the molecular weight of gelatin is large, and it is sterically hindered little, contributes to the stability promoting its triple-helix structure.
Wherein, methoxyl content in described hydroxypropyl emthylcellulose is 20-25%, hydroxypropyl content is 8%-12%, and at 20 DEG C, mass concentration is aqueous solution (namely hydroxypropyl emthylcellulose mass concentration is in aqueous the 2%) medium viscosity of 2% is 10-20mPa.s.
Hydroxypropyl emthylcellulose is called for short HPMC, there is hot gelling properties, hydroxypropyl emthylcellulose of the present invention, its methoxyl content is 20-25%, hydroxypropyl content is 8%-12%, and at 20 DEG C, mass concentration is the aqueous solution medium viscosity of 2% is 10-20mPa.s, its gelling temp (0.2%) is 60-90 DEG C, there is good thickening capabilities, salt discharge, PH stability, water-retaining property, dimensional stability, excellent film property and the feature such as resistance to enzymatic, dispersibility and caking property widely.
The aqueous solution of hydroxypropyl emthylcellulose has surface activity, and transparency is high, the advantage of stable performance, and itself and gelatin are used in combination, and gelling performance is more excellent, greatly improves dispersibility and the stability of nano material dispersion, the good stability of obtained Capsules.
Wherein, described Polyethylene Glycol is one or both in PEG400, PEG4000.
Polyethylene Glycol is called for short that PEG, PEG400 are liquid, it has the extensive compatibility with various solvent, is good solvent and solubilizing agent, is widely used in liquid preparation, as oral liquid, eye drop etc.The PEG4000 of high molecular is used as substrate in medicine, cosmetics industry in producing, and plays adjusting viscosity, fusing point.Preferably, the mixture of described Polyethylene Glycol to be PEG400, PEG4000 with mass ratio be 3-5:1-2.PEG400 mixes with the PEG4000 phase of high molecular, and its mixture has good dissolubility and good and drug compatibility, can prevent bonding between Capsules and bonding with between medicine bottle.
A kind of containing nano-TiO
2the preparation method of Capsules, comprise the following steps:
(1) weigh: take the major ingredient of formula ratio, plasticizer, tween 80, titanium dioxide, pigment, nano-TiO
2, water is for subsequent use;
(2) nano material dispersion is prepared: by plasticizer, tween 80, nano-TiO
2and water, be dispersed into nano material dispersion by ultrasound wave;
(3) colloidal sol: by major ingredient, titanium dioxide, pigment mix homogeneously, then add above-mentioned nano material dispersion, colloidal sol under 50-75 DEG C of condition;
(4) prepare Capsules: after mix and blend, carry out dipping in glue glue capsule base with the stainless steel mould of given size, capsule base is dry sclerosis under 50-90 DEG C of condition, through pulling out shell, cut and arrange after, make Capsules, the moisture Control of Capsules is at 10-18%.
Wherein, in described step (2), hyperacoustic frequency of vibration is 20-25KHz.
Wherein, in described step (3), collosol temperature is 55-65 DEG C.
Wherein, in described step (4), capsule base is dry sclerosis under 60-80 DEG C of condition, and the moisture Control of Capsules is at 12.5-17.5%.
Beneficial effect of the present invention:
Nano-TiO
2the size of microgranule and ultraviolet light wave wavelength quite or less time, small-size effect causes light absorption to strengthen, and produces light shield effect and improve the uvioresistant Anti-tarnishing function of material; Meanwhile, nano-TiO
2produce electronics one hole pair by illumination, and active very strong free radical and superoxide ion can be formed, microorganism killing is produced antibacterial functions.
The present invention adopts the medicinal raw material of safety non-toxic through processing and fabricating containing the Capsules system of nano TiO 2, and it not only has the characteristic of general capsule, but also has uvioresistant Anti-tarnish property and from antibacterial functions, makes that product stability is good, the storage life is long.The preparation method of Capsules, technique is simple, is conducive to applying.
Warp is to containing nano-TiO
2capsule and the capsule of contrast carried out superior function test, of the present invention containing nano-TiO
2capsules every investigation result more constant with 0 month, and not containing nano-TiO
2capsule every investigation result compared with 0 month and there occurs larger change.Result shows of the present invention containing nano-TiO
2capsules there is stronger superiority, its uvioresistant Anti-tarnish property is good, good from antibacterial functions.
Detailed description of the invention
The invention will be further described with the following Examples.
Embodiment 1
The one of the present embodiment is containing nano-TiO
2capsules, be made up of the raw material of following weight portion:
Major ingredient: 50 parts, plasticizer: 2 parts, tween 80: 2 parts, titanium dioxide: 15 parts, pigment: 3 parts, nano-TiO
2: 2-part, water: 30 parts.
Wherein, described major ingredient is gelatin; The amino acid whose content in the described gelatin Central Asia is 15% of gelatin gross mass.
Wherein, described plasticizer is glycerol.
Described nano-TiO
2particle diameter be 50nm.
Described pigment is at least one in light blue, lemon yellow, ferrum oxide.
The one of the present embodiment is containing nano-TiO
2the preparation method of Capsules, comprise the following steps:
(1) weigh: take the major ingredient of formula ratio, plasticizer, tween 80, titanium dioxide, pigment, nano-TiO
2, water is for subsequent use;
(2) nano material dispersion is prepared: by plasticizer, tween 80, nano-TiO
2and water, be dispersed into nano material dispersion by ultrasound wave, hyperacoustic frequency of vibration is 20KHz;
(3) colloidal sol: by major ingredient, titanium dioxide, pigment mix homogeneously, then add above-mentioned nano material dispersion, colloidal sol under 50 DEG C of conditions;
(4) prepare Capsules: after mix and blend, carry out dipping in glue glue capsule base with mould, capsule base is dry sclerosis under 50 DEG C of conditions, and through pulling out shell, cut and after arranging, make Capsules, the moisture Control of Capsules is 18%.
Embodiment 2
The one of the present embodiment is containing nano-TiO
2capsules, be made up of the raw material of following weight portion:
Major ingredient: 52 parts, plasticizer: 3 parts, tween 80: 3 parts, titanium dioxide: 18 parts, pigment: 4 parts, nano-TiO
2: 3 parts, water: 32 parts.
Wherein, described major ingredient is hydroxypropyl emthylcellulose; Methoxyl content in described hydroxypropyl emthylcellulose is 23%, and hydroxypropyl content is 10%, and at 20 DEG C, mass concentration is the aqueous solution medium viscosity of 2% is 18mPa.s.
Wherein, described plasticizer Polyethylene Glycol.The mixture of described Polyethylene Glycol to be PEG400, PEG4000 with mass ratio be 3:1.
Described nano-TiO
2particle diameter be 60nm.
Described pigment is at least one in light blue, lemon yellow, ferrum oxide.
The one of the present embodiment is containing nano-TiO
2the preparation method of Capsules, comprise the following steps:
(1) weigh: take the major ingredient of formula ratio, plasticizer, tween 80, titanium dioxide, pigment, nano-TiO
2, water is for subsequent use;
(2) nano material dispersion is prepared: by plasticizer, tween 80, nano-TiO
2and water, be dispersed into nano material dispersion by ultrasound wave, hyperacoustic frequency of vibration is 21KHz;
(3) colloidal sol: by major ingredient, titanium dioxide, pigment mix homogeneously, then add above-mentioned nano material dispersion, colloidal sol under 55 DEG C of conditions;
(4) prepare Capsules: after mix and blend, carry out dipping in glue glue capsule base with mould, capsule base is dry sclerosis under 60 DEG C of conditions, and through pulling out shell, cut and after arranging, make Capsules, the moisture Control of Capsules is 17.5%.
Embodiment 3
The one of the present embodiment is containing nano-TiO
2capsules, be made up of the raw material of following weight portion:
Major ingredient: 55 parts, plasticizer: 5 parts, tween 80: 5 parts, titanium dioxide: 20 parts, pigment: 5 parts, nano-TiO
2: 5 parts, water: 35 parts.
Wherein, the mixture of described major ingredient to be gelatin, hydroxypropyl emthylcellulose with mass ratio be 2:1;
The amino acid whose content in the described gelatin Central Asia is 12% of gelatin gross mass.
Methoxyl content in described hydroxypropyl emthylcellulose is 20%, and hydroxypropyl content is 12%, and at 20 DEG C, mass concentration is the aqueous solution medium viscosity of 2% is 15mPa.s.
Wherein, described plasticizer is Polyethylene Glycol.The mixture of described Polyethylene Glycol to be PEG400, PEG4000 with mass ratio be 4:1.5.
Described nano-TiO
2particle diameter be 75nm.
Described pigment is at least one in light blue, lemon yellow, ferrum oxide.
The one of the present embodiment is containing nano-TiO
2the preparation method of Capsules, comprise the following steps:
(1) weigh: take the major ingredient of formula ratio, plasticizer, tween 80, titanium dioxide, pigment, nano-TiO
2, water is for subsequent use;
(2) nano material dispersion is prepared: by plasticizer, tween 80, nano-TiO
2and water, be dispersed into nano material dispersion by ultrasound wave, hyperacoustic frequency of vibration is 22KHz;
(3) colloidal sol: by major ingredient, titanium dioxide, pigment mix homogeneously, then add above-mentioned nano material dispersion, colloidal sol under 60 DEG C of conditions;
(4) prepare Capsules: after mix and blend, carry out dipping in glue glue capsule base with mould, capsule base is dry sclerosis under 70 DEG C of conditions, and through pulling out shell, cut and after arranging, make Capsules, the moisture Control of Capsules is 15%.
Embodiment 4
The one of the present embodiment is containing nano-TiO
2capsules, be made up of the raw material of following weight portion:
Major ingredient: 58 parts, plasticizer: 6 parts, tween 80: 6 parts, titanium dioxide: 22 parts, pigment: 6 parts, nano-TiO
2: 8 parts, water: 38 parts.
Wherein, the mixture of described major ingredient to be gelatin, hydroxypropyl emthylcellulose with mass ratio be 3:1;
The amino acid whose content in the described gelatin Central Asia is 16% of gelatin gross mass.
Methoxyl content in described hydroxypropyl emthylcellulose is 25%, and hydroxypropyl content is 8%%, and at 20 DEG C, mass concentration is the aqueous solution medium viscosity of 2% is 12mPa.s.
Wherein, the mixture of described plasticizer to be glycerol, Polyethylene Glycol with mass ratio be 2:1.Described Polyethylene Glycol is PEG400.
Described nano-TiO
2particle diameter be 80nm.
Described pigment is at least one in light blue, lemon yellow, ferrum oxide.
The one of the present embodiment is containing nano-TiO
2the preparation method of Capsules, comprise the following steps:
(1) weigh: take the major ingredient of formula ratio, plasticizer, tween 80, titanium dioxide, pigment, nano-TiO
2, water is for subsequent use;
(2) nano material dispersion is prepared: by plasticizer, tween 80, nano-TiO
2and water, be dispersed into nano material dispersion by ultrasound wave, hyperacoustic frequency of vibration is 23KHz;
(3) colloidal sol: by major ingredient, titanium dioxide, pigment mix homogeneously, then add above-mentioned nano material dispersion, colloidal sol under 65 DEG C of conditions;
(4) prepare Capsules: after mix and blend, carry out dipping in glue glue capsule base with mould, capsule base is dry sclerosis under 80 DEG C of conditions, and through pulling out shell, cut and after arranging, make Capsules, the moisture Control of Capsules is 12.5%.
Embodiment 5
The one of the present embodiment is containing nano-TiO
2capsules, be made up of the raw material of following weight portion:
Major ingredient: 60 parts, plasticizer: 8 parts, tween 80: 8 parts, titanium dioxide: 25 parts, pigment: 8 parts, nano-TiO
2: 10 parts, water: 40 parts.
Wherein, described major ingredient is hydroxypropyl emthylcellulose; Methoxyl content in described hydroxypropyl emthylcellulose is 22%, and hydroxypropyl content is 11%, and at 20 DEG C, mass concentration is the aqueous solution medium viscosity of 2% is 10mPa.s.
Wherein, the mixture of described plasticizer to be glycerol, Polyethylene Glycol with mass ratio be 3:1.The mixture of described Polyethylene Glycol to be PEG400, PEG4000 with mass ratio be 5:1.
Described nano-TiO
2particle diameter be 100nm.
Described pigment is at least one in light blue, lemon yellow, ferrum oxide.
The one of the present embodiment is containing nano-TiO
2the preparation method of Capsules, comprise the following steps:
(1) weigh: take the major ingredient of formula ratio, plasticizer, tween 80, titanium dioxide, pigment, nano-TiO
2, water is for subsequent use;
(2) nano material dispersion is prepared: by plasticizer, tween 80, nano-TiO
2and water, be dispersed into nano material dispersion by ultrasound wave, hyperacoustic frequency of vibration is 25KHz;
(3) colloidal sol: by major ingredient, titanium dioxide, pigment mix homogeneously, then add above-mentioned nano material dispersion, colloidal sol under 75 DEG C of conditions;
(4) prepare Capsules: after mix and blend, carry out dipping in glue glue capsule base with mould, capsule base is dry sclerosis under 90 DEG C of conditions, and through pulling out shell, cut and after arranging, make Capsules, the moisture Control of Capsules is 10%.
In order to confirm that it is not than more superior containing nano material capsule performance, now two kinds of capsule materials are carried out accelerated test 6 months by plan listing packaging, room temperature natural reserved 12 months, regular sampling, key project is compared, detects according to the pertinent regulations of investigation project according to the Pharmacopoeia of the People's Republic of China 2010 editions.
(1) accelerated test
Experimental condition: temperature 40 ± 1 DEG C, RH75%
Sample packaging: PVC is packed
Sample source: research and development centre of company provides
Lot number: (contrast) 20130801(is containing nano-TiO
2) 20130803
Investigation project: aberration (△ E value) Micro biological Tests
Test method:
Will containing nano-TiO
2capsule and not containing nano-TiO
2each 1 batch sample of the capsule calorstat that mid-40 ± 1 DEG C of the hermetic container of saturated nacl aqueous solution (RH75%) is equipped with in bottom set portion respectively in place 6 months in 0,1,2,3, June timing sampling, detect according to the pertinent regulations of investigation project according to the Pharmacopoeia of the People's Republic of China 2010 editions, the results are shown in Table 1.
Table 1 accelerated test investigation table
(2) room temperature keeps sample investigation:
Experimental condition: room temperature is placed naturally (temperature 25 DEG C ± 2 DEG C, RH60 ± 10%)
Sample packaging: PVC is packed
Sample source: research and development centre of company provides
Lot number: (contrast) 20130801(is containing nano-TiO
2) 20130803
Investigation project: aberration (△ E value) Micro biological Tests
Test method:
Will containing nano-TiO
2capsule and not containing nano-TiO
2each 1 batch sample of capsule put room temperature respectively and place, in 0,3,6,9, December timing sampling, detect according to the pertinent regulations of investigation project according to the Pharmacopoeia of the People's Republic of China 2010 editions, the results are shown in Table 2.
Table 2: room temperature experiment investigation table
(3) conclusion:
As can be seen from Table 1, in accelerated test: the Capsules of the application was when storage 0 month, and its aberration is 0, and bacterial population is 7/g, fungi count is 24/g, preserves after 6 months, and its aberration is 0.49, bacterial population is 13/g, and fungi count is 40/g, and reference examples is not (containing nano-TiO
2) in preservation after 6 months, its aberration is 5.38 times of the aberration of the application, and its bacterial population is 2.69 times of the bacterial population of the application, and its fungi count is 3.05 times of the application.
As can be seen from Table 2, in room temperature keeps sample and investigates: the Capsules of the application was when storage 0 month, and its aberration is 0, and bacterial population is 6/g, fungi count is 24/g, preserves after 6 months, and its aberration is 0.38, bacterial population is 12/g, and fungi count is 31/g, and reference examples is not (containing nano-TiO
2) in preservation after 6 months, its aberration is 5.39 times of the aberration of the application, and bacterial population is 2.5 times of the bacterial population of the application, and its fungi count is 2.87 times of the application.
Warp is to containing nano-TiO
2capsule and the capsule of contrast carried out superior function test, consolidated statement 1 table 2 is analyzed, of the present invention containing nano-TiO
2capsules every investigation result more constant with 0 month, and not containing nano-TiO
2capsule every investigation result compared with 0 month and there occurs larger change.Result shows of the present invention containing nano-TiO
2capsules there is stronger superiority, its uvioresistant Anti-tarnish property is good, good from antibacterial functions.
Finally should be noted that; above embodiment is only in order to illustrate technical scheme of the present invention; but not limiting the scope of the invention; although done to explain to the present invention with reference to preferred embodiment; those of ordinary skill in the art is to be understood that; can modify to technical scheme of the present invention or equivalent replacement, and not depart from essence and the scope of technical solution of the present invention.
Claims (10)
1. one kind contains nano-TiO
2capsules, it is characterized in that: be made up of the raw material of following weight portion:
Major ingredient 50-60 part
Plasticizer 2-8 part
Tween 80 2-8 part
Titanium dioxide 15-25 part
Pigment 3-8 part
Nano-TiO
22-10 part
Water 30-40 part
Wherein, described major ingredient is one or both in gelatin, hydroxypropyl emthylcellulose;
Wherein, described plasticizer is one or both in glycerol, Polyethylene Glycol.
2. one according to claim 1 is containing nano-TiO
2capsules, it is characterized in that: be made up of the raw material of following weight portion:
Major ingredient 50-55 part
Plasticizer 3-5 part
Tween 80 3-5 part
Titanium dioxide 15-20 part
Pigment 3-5 part
Nano-TiO
22-5 part
Water 30-40 part.
3. one according to claim 1 is containing nano-TiO
2capsules, it is characterized in that: described nano-TiO
2particle diameter be 50-100nm.
4. one according to claim 1 is containing nano-TiO
2capsules, it is characterized in that: described pigment is at least one in light blue, lemon yellow, ferrum oxide.
5. one according to claim 1 is containing nano-TiO
2capsules, it is characterized in that: the amino acid whose content in the described gelatin Central Asia is the 10-20% of gelatin gross mass.
6. one according to claim 1 is containing nano-TiO
2capsules, it is characterized in that: the methoxyl content in described hydroxypropyl emthylcellulose is 20-25%, hydroxypropyl content is 8%-12%, and at 20 DEG C, mass concentration is the aqueous solution medium viscosity of 2% is 10-20mPa.s.
7. one according to claim 1 is containing nano-TiO
2capsules, it is characterized in that: described Polyethylene Glycol is one or both in PEG400, PEG4000.
8. the one described in claim 1-7 any one is containing nano-TiO
2the preparation method of Capsules, it is characterized in that: comprise the following steps:
(1) weigh: take the major ingredient of formula ratio, plasticizer, tween 80, titanium dioxide, pigment, nano-TiO
2, water is for subsequent use;
(2) nano material dispersion is prepared: by plasticizer, tween 80, nano-TiO
2and water, be dispersed into nano material dispersion by ultrasound wave;
(3) colloidal sol: by major ingredient, titanium dioxide, pigment mix homogeneously, then add above-mentioned nano material dispersion, colloidal sol under 50-75 DEG C of condition;
(4) prepare Capsules: after colloidal sol raw material mix and blend, carry out dipping in glue glue capsule base with mould, capsule base is dry sclerosis under 50-90 DEG C of condition, and through pulling out shell, cut and after arranging, make Capsules, the moisture Control of Capsules is at 10-18%.
9. one according to claim 8 is containing nano-TiO
2the preparation method of Capsules, it is characterized in that: in described step (2), hyperacoustic frequency of vibration is 20-25KHz.
10. one according to claim 8 is containing nano-TiO
2the preparation method of Capsules, it is characterized in that: in described step (3), collosol temperature is 55-65 DEG C; In described step (4), capsule base is dry sclerosis under 60-80 DEG C of condition, and the moisture Control of Capsules is at 12.5-17.5%.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113813241A (en) * | 2021-11-12 | 2021-12-21 | 江西维莱营健高科有限公司 | Wild jujube seed capsule and preparation method thereof |
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| CN113813241A (en) * | 2021-11-12 | 2021-12-21 | 江西维莱营健高科有限公司 | Wild jujube seed capsule and preparation method thereof |
| CN113813241B (en) * | 2021-11-12 | 2022-05-17 | 江西维莱营健高科有限公司 | Wild jujube seed capsule and preparation method thereof |
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