CN102703302A - Installing seat for automatically clamping sequencing chip - Google Patents
Installing seat for automatically clamping sequencing chip Download PDFInfo
- Publication number
- CN102703302A CN102703302A CN201210165663XA CN201210165663A CN102703302A CN 102703302 A CN102703302 A CN 102703302A CN 201210165663X A CN201210165663X A CN 201210165663XA CN 201210165663 A CN201210165663 A CN 201210165663A CN 102703302 A CN102703302 A CN 102703302A
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- testing chip
- installation cavity
- locating slot
- sequence testing
- mount pad
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Abstract
The invention discloses an installing seat for automatically clamping a sequencing chip, which comprises an installing cavity for accommodating the sequencing chip. One end of the installing cavity is provided with a positioning ring for positioning the sequencing chip. The installing seat is characterized in that a plurality of positioning grooves running through an inner wall are arranged on the inner wall of the installing cavity along the radial direction of the installing cavity; the positioning grooves are uniformly distributed along the circumference of the installing cavity; and a sliding tongue plate is arranged in each positioning groove, wherein each sliding tongue plate slides along the corresponding positioning groove to extend into the installing cavity to clamp the sequencing chip so as to ensure the sequencing chip to be attached to the positioning ring and retracts into the positioning groove along the positioning groove to loosen the sequencing chip. According to the installing seat for automatically clamping the sequencing chip, which is disclosed by the invention, the sliding tongue plates which can be automatically popped up are set to extend into the installing cavity to clamp the sequencing chip and retract into the corresponding installation positioning grooves under the action of an external force, so that the rapid assembly and disassembly of the sequencing chip are implemented and the sequencing efficiency is improved.
Description
Technical field
The present invention relates to the dna sequencing technical field, be specifically related to a kind of mount pad that holds sequence testing chip automatically.
Background technology
The tetra-sodium sequencing technologies is by the enzyme cascade chemiluminescence reaction in 4 kinds of enzymatic same reaction systems.The principle of tetra-sodium sequencing technologies is: after primer and the template DNA annealing; Under the synergy of archaeal dna polymerase (DNA polymerase), ATP sulfurylase (ATP sulfurylase), luciferase (luciferase) and four kinds of enzymes of apyrase (Apyrase); The polymerization of each dNTP on the primer and the release coupling of an optical signal are got up; Through detecting the release and the intensity of light, reach the purpose of The real time measure dna sequence dna.The reaction system of tetra-sodium sequencing technologies is made up of reaction substrate, strand to be measured, sequencing primer and four kinds of enzymes.Reaction substrate be 5 '-phosphinylidyne sulfuric acid (adenosine-5 '-phosphosulfate, APS) and resorcinolphthalein (luciferin).
Take turns in the sequencing reaction at each; Only add a kind of deoxynucleotide triphosphoric acid (dNTP) in the reaction system; If it can just with the next base pairing of dna profiling; Then can under the effect of archaeal dna polymerase, add 3 ' end of sequencing primer to, discharge the tetra-sodium (PPi) of a molecule simultaneously.Under the effect of ATP sulfurylase, the PPi of generation can combine to form ATP with APS, and under the catalysis of luciferase, the ATP of generation can combine to form oxyluciferin again with resorcinolphthalein, produces visible light simultaneously.Can obtain a special detected peaks through Weak light detection device and process software, the height of peak value then is directly proportional with the base number that is complementary.If the dNTP that adds can not with the next base pairing of dna profiling, then above-mentionedly instead would not take place, just do not have detected peaks yet.Remaining dNTP and residual a small amount of ATP degrade under the effect of Apyrase in the reaction system.After treating that last round of reaction is accomplished, add another kind of dNTP, above-mentioned reaction is repeated, promptly can read dna sequence dna information accurately according to the peak value figure that obtains.
The integrated operation flow process is described below: the DNA sample through fragmentation after; Application builds that storehouse reagent adds joint, microballoon, microemulsion pcr amplification, breakdown of emulsion liquid are caught, are bonded to strand; Acquisition is based upon the DNA library on the microballoon; Application add model with the laies such as enzyme of library and sequencing reaction needs to sequence testing chip with micro reaction pool, sequence testing chip and sequencing reagent are mounted on the main frame, start the order-checking program through control computer according to module number and position; Sequencing reaction is carried out in robotization; Data transmission to the data analysis computingmachine that produces is accomplished the order-checking back and is used calculating analysis software and carry out work such as picture processing, sequence are read, mass analysis, sequence assembly, finally obtains the sequence information of dna sample.
Before carrying out sequencing reaction, need be installed to sequence testing chip in the installation cavity of mount pad, so that carry out sequencing reaction, therefore, how to load and unload the major issue that sequence testing chip becomes influence order-checking efficient fast.
Summary of the invention
The problem that the present invention will solve is, a kind of mount pad of being convenient to install sequence testing chip is provided, so that can load and unload sequence testing chip fast, improves the working efficiency of order-checking.
For addressing the above problem; The invention provides a kind of mount pad that holds sequence testing chip automatically; Comprise the installation cavity that is used for ccontaining said sequence testing chip; One end of said installation cavity is provided with the retaining ring that is used to locate said sequence testing chip; It radially is provided with the locating slot of the said inwall of a plurality of perforations the inwall upper edge of said installation cavity, and said locating slot is along the circumference uniform distribution of said installation cavity, and being equipped with in each said locating slot slides to stretch in the said installation cavity to hold said sequence testing chip along said locating slot is close on the said retaining ring it and withdraws in the said locating slot to unclamp the slip hyoplastron of said sequence testing chip along said locating slot.
As preferably, said locating slot is less near one section size of said installation cavity, is formed for the first step of spacing said slip hyoplastron; Said locating slot is provided with the baffle plate that is fixedly connected with said mount pad away from an end of said installation cavity; It is interior to hold said sequence testing chip that one end of said slip hyoplastron stretches into said installation cavity, and said slip hyoplastron is provided with and when an end of said slip hyoplastron stretches out, is against the boss on the said first step; Be provided with between said boss and the said baffle plate and make said slip hyoplastron stretch into the elastic component in the said installation cavity.
As preferably, said elastic component is a spring.
As preferably; Said spring housing is on the said slip hyoplastron between said boss and the said baffle plate; Said baffle plate is provided with the through hole that supplies said slip hyoplastron to pass away from an end of said installation cavity; The inboard of said baffle plate is provided with the cover of internal diameter greater than said through hole, the end that is formed for making said spring between said cover and the through hole against second step.
As preferably, the quantity of said locating slot is 2 or 4.
As preferably, said locating slot is a circle hole shape.
Automatically the mount pad that holds sequence testing chip of the present invention is from stretching into installation cavity to hold sequence testing chip and under external force, in the withdrawal mounting positioning groove, to realize loading and unloading fast sequence testing chip, to improve order-checking efficient through the slip hyoplastron that can eject automatically is set.
Description of drawings
Fig. 1 is the front view of the mount pad that holds sequence testing chip automatically when sequence testing chip is not installed of embodiments of the invention;
Fig. 2 is that the A-A of Fig. 1 is to sectional view;
Fig. 3 is the front view of the mount pad that holds sequence testing chip automatically when sequence testing chip is installed of embodiments of the invention;
Fig. 4 is that the B-B of Fig. 3 is to sectional view;
Fig. 5 is that the C-C of Fig. 4 is to sectional view;
Fig. 6 looks synoptic diagram for the master of the slip hyoplastron in the mount pad that holds sequence testing chip automatically of embodiments of the invention;
Fig. 7 looks synoptic diagram for the left side of Fig. 6;
Fig. 8 is the schematic perspective view of the baffle plate that holds sequence testing chip automatically of embodiments of the invention;
Fig. 9 is the side-view of Fig. 8;
Figure 10 be Fig. 9 along D-D to sectional view.
Main description of reference numerals
1-mount pad 2-slip hyoplastron 3-spring
4-baffle plate 5-sequence testing chip 6-locating slot
11-retaining ring 21-boss 45-cover
19-installation cavity 41-screw 63-first step
44-through hole 49-second step
Embodiment
Below in conjunction with accompanying drawing and specific embodiment the present invention is described in further detail, but not as to qualification of the present invention.
Like Fig. 1-shown in Figure 5; Automatically the mount pad that holds sequence testing chip 1 of one embodiment of the present of invention; Comprise the installation cavity 19 that is used for ccontaining sequence testing chip 5; One end of installation cavity 19 is provided with the retaining ring 11 that is used to locate sequence testing chip 5, and it radially is provided with locating slot 6 the inwall upper edge of installation cavity 19, be provided with in the locating slot 6 along locating slot 6 slide stretch in the installation cavity 19 with hold sequence testing chip 5 make it be attached on the retaining ring 11 or withdrawal locating slot 19 in to unclamp the slip hyoplastron 2 of sequence testing chip 5.When slip hyoplastron 2 stretches out and the distance between the retaining ring 11 equal sequence testing chip thickness just, sequence testing chip 5 is adjacent on retaining ring 11.Locating slot 6 symmetries are located on the inwall of installation cavity 19 and connect inwall, and its quantity can be even numbers such as two or four, and in order stable holding to live sequence testing chip 5, locating slot 6 is along the circumferential direction uniform distribution of installation cavity 19.Certainly, for improve holding force can also be provided with more a plurality of, but more locating slot 6 can cause the inconvenience of operation.In the present embodiment, locating slot 6 is two, and for easy to process, locating slot 6 is a circle hole shape.
As shown in Figure 2, locating slot 6 is less near one section size of installation cavity 19, is formed for the first step 63 of spacing slip hyoplastron 2; Be locating slot 6 near a section of installation cavity 19 be a less circular hole, rest part is a bigger circular hole.Like Fig. 6 and shown in Figure 7, slip hyoplastron 2 is provided with the boss 21 of protrusion.As shown in Figure 4, when slip hyoplastron 2 when installation cavity 19 stretches into, the boss 21 of slip hyoplastron 2 is resisted against said first step 63 places, an end of slip hyoplastron 2 stretches in the installation cavity 19 to hold sequence testing chip 5.The outer end of locating slot 6 is provided with the baffle plate 4 that is fixedly connected with mount pad 1; Between the boss 21 of slip hyoplastron 2 and baffle plate 4, be provided with spring 3; In the present embodiment, spring 3 is enclosed within the other end of slip hyoplastron 2, and the two ends of spring 3 are resisted against respectively on boss 21 and the baffle plate 4.
As shown in Figure 5, baffle plate 4 is fixedly connected with mount pad 1 through two screws 41, is convenient to installation and removal.Spring 3 is enclosed within on the slip hyoplastron 2 between boss 21 and the baffle plate 4; Like Fig. 8-shown in Figure 10; Baffle plate 4 is provided with the through hole 44 that supplies slip hyoplastron 2 to pass away from an end of installation cavity 19; The inboard of baffle plate 4 is provided with the cover 45 of internal diameter greater than through hole 44, the end that is formed for making spring 3 between cover 45 and the through hole against second step 49.
In the present embodiment, spring 3 can also adopt other elastic components to replace, and baffle plate 4 can also adopt miscellaneous part, as long as can be against the other end of spring 3.When sequence testing chip 5 is installed, stir the end in the installation cavity 19 that extend into of slip hyoplastron 2, make in its withdrawal locating slot 6; Boss 21 extrusion springs 3 of slip hyoplastron 2; Unclamp slip hyoplastron 2 after putting into sequence testing chip 5 installation cavity 19 and be attached on the retaining ring 11, slip hyoplastron 2 stretches out under the effect of spring 3, is clamped in the side of sequence testing chip 5; Sequence testing chip 5 is adjacent on retaining ring 11, even also unlikelyly when guaranteeing that sequence testing chip 5 is inverted deviate from.
Certainly, the above is a preferred implementation of the present invention, should be understood that; For those skilled in the art; Under the prerequisite that does not break away from the principle of the invention, can also make some improvement and retouching, these improvement and retouching also are regarded as protection scope of the present invention.
Claims (6)
1. mount pad that holds sequence testing chip automatically; Comprise the installation cavity that is used for ccontaining said sequence testing chip; One end of said installation cavity is provided with the retaining ring that is used to locate said sequence testing chip; It is characterized in that; It radially is provided with the locating slot of the said inwall of a plurality of perforations the inwall upper edge of said installation cavity, and said locating slot is along the circumference uniform distribution of said installation cavity, and being equipped with in each said locating slot slides to stretch in the said installation cavity to hold said sequence testing chip along said locating slot is close on the said retaining ring it and withdraws in the said locating slot to unclamp the slip hyoplastron of said sequence testing chip along said locating slot.
2. the mount pad that holds sequence testing chip automatically as claimed in claim 1 is characterized in that, said locating slot is less near one section size of said installation cavity, is formed for the first step of spacing said slip hyoplastron; Said locating slot is provided with the baffle plate that is fixedly connected with said mount pad away from an end of said installation cavity;
It is interior to hold said sequence testing chip that one end of said slip hyoplastron stretches into said installation cavity, and said slip hyoplastron is provided with and when an end of said slip hyoplastron stretches out, is against the boss on the said first step;
Be provided with between said boss and the said baffle plate and make said slip hyoplastron stretch into the elastic component in the said installation cavity.
3. the mount pad that holds sequence testing chip automatically as claimed in claim 2 is characterized in that, said elastic component is a spring.
4. the mount pad that holds sequence testing chip automatically as claimed in claim 3; It is characterized in that; Said spring housing is on the said slip hyoplastron between said boss and the said baffle plate; Said baffle plate is provided with the through hole that supplies said slip hyoplastron to pass away from an end of said installation cavity, and the inboard of said baffle plate is provided with the cover of internal diameter greater than said through hole, the end that is formed for making said spring between said cover and the through hole against second step.
5. according to claim 1 or claim 2 the mount pad that holds sequence testing chip automatically is characterized in that the quantity of said locating slot is 2 or 4.
6. according to claim 1 or claim 2 the mount pad that holds sequence testing chip automatically is characterized in that said locating slot is a circle hole shape.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210165663XA CN102703302B (en) | 2012-05-24 | 2012-05-24 | Installing seat for automatically clamping sequencing chip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210165663XA CN102703302B (en) | 2012-05-24 | 2012-05-24 | Installing seat for automatically clamping sequencing chip |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102703302A true CN102703302A (en) | 2012-10-03 |
| CN102703302B CN102703302B (en) | 2013-11-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210165663XA Active CN102703302B (en) | 2012-05-24 | 2012-05-24 | Installing seat for automatically clamping sequencing chip |
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| CN105219640B (en) * | 2015-11-02 | 2017-09-08 | 北京中科紫鑫科技有限责任公司 | A kind of box DNA sequencer with frame shock-damping structure |
| CN105296346B (en) * | 2015-11-02 | 2017-09-12 | 北京中科紫鑫科技有限责任公司 | A kind of box DNA sequencer of the dual shockproof framework with liner plate |
| CN105524827A (en) * | 2015-12-02 | 2016-04-27 | 北京中科紫鑫科技有限责任公司 | DNA image capturing and sequencing system with linkage adjustment function |
| CN105420096A (en) * | 2015-12-02 | 2016-03-23 | 北京中科紫鑫科技有限责任公司 | DNA image collecting and sequencing system based on reaction temperature adjustment |
| CN105400689A (en) * | 2015-12-02 | 2016-03-16 | 北京中科紫鑫科技有限责任公司 | Image processing system applied to DNA sequencing |
| CN105400689B (en) * | 2015-12-02 | 2017-06-23 | 北京中科紫鑫科技有限责任公司 | A kind of image processing system for being applied to DNA sequencing |
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| CN102703302B (en) | 2013-11-27 |
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