CN105385590B - The box DNA sequencer that a kind of test solution is supplied automatically - Google Patents
The box DNA sequencer that a kind of test solution is supplied automatically Download PDFInfo
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- CN105385590B CN105385590B CN201510731398.0A CN201510731398A CN105385590B CN 105385590 B CN105385590 B CN 105385590B CN 201510731398 A CN201510731398 A CN 201510731398A CN 105385590 B CN105385590 B CN 105385590B
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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Abstract
The present invention relates to the box DNA sequencer that a kind of test solution is supplied automatically, it includes reaction record subsystem, agent delivery system and control system, and carry the sequenator casing of above-mentioned each system, agent delivery system, including buffering liquid case loading/unloading platform component, liquid case hoistable platform component, the integrated tube assembly of pump valve are provided with right case；Wherein, described buffering liquid case loading/unloading platform can load and unload various reagents, and the position specified is transported to up and down by liquid case hoistable platform component, the Reagent Tube that the integrated tube assembly selection of pump valve needs, driving and the open and close controlling of hydraulic valve through hydraulic pump, will be reacted in specified reagent delivery to reaction warehouse component.The box DNA sequencer that test solution of the invention is supplied automatically, liquid case hoistable platform component is moved reagent delivery to specified location by guide rail, easy to control, accurate；Liquid case hoistable platform transports the gentle fliud flushing case loading/unloading platform component of the integrated tube assembly of pump valve up and down.
Description
Technical field
The present invention relates to DNA sequencing field, more particularly to the box DNA sequencer that a kind of test solution is supplied automatically.
Background technology
During DNA sequencing, chemically reacted on sequence testing chip, visible ray is produced, by CCD (Charge
Couple Device) optical signal produced by cameras capture sequencing reaction, you can obtain required sequencing information.
Agent delivery system in reaction chip to providing plurality of reagents, it is desirable to which DNA sequencer can store, defeated as desired
Send, and be convenient for changing reagent；During storage, conveying and changing reagent, it is necessary to convenient control, so as to the examination of supply
Agent persistently reacts with the sequence testing chip in reaction warehouse, completes sequencing procedure.
In view of drawbacks described above, creator of the present invention passes through prolonged research and practice obtains this creation finally.
The content of the invention
It is an object of the invention to provide the box DNA sequencer that a kind of test solution is supplied automatically, it is used to overcome above-mentioned technology
Defect.
To achieve the above object, the present invention provides the box DNA sequencer that a kind of test solution is supplied automatically, and it includes reaction note
Record subsystem, agent delivery system and control system, and the sequenator casing of above-mentioned each system is carried, wherein, described is anti-
Subsystem should be recorded and agent delivery system is separately positioned in left and right two parts interval of sequenator casing, and by being arranged on
Agent delivery pipeline connection in casing；Reaction record subsystem of the described set-up of control system in interval on the left of casing
Rear side；
Agent delivery system, including buffering liquid case loading/unloading platform component, liquid case hoistable platform group are provided with right case
The integrated tube assembly of part, pump valve；Wherein,
Described buffering liquid case loading/unloading platform can load and unload various reagents, and by the fortune up and down of liquid case hoistable platform component
The position specified is delivered to, for described pump valve integrated pipe Component driver, the Reagent Tube that the integrated tube assembly selection of pump valve needs,
Driving and the open and close controlling of hydraulic valve through hydraulic pump, will be reacted in specified reagent delivery to reaction warehouse component；
The action of above-mentioned each element is controlled by control unit unification；
Casing includes body supports component, is arranged on the liner board component on the inside of body supports component, body supports component
The bottom of supporting box, sidepiece, two cutting parts of housing area in rear portion and left and right.
Further, described liquid case hoistable platform component is the mechanism that pumps that motor leading screw drives, its peace
In the right side casing of sequenator；
It include motor and motor connect and support motor support base and motor connection
Lead screw assembly, the liquid case lifting seat of the reaction installed in sidepiece, wherein,
Buffer solution case loading/unloading platform component is equiped with described reaction liquid case lifting seat, reaction is pacified with liquid case lifting seat
On the installing plate being connected with reaction liquid case lifting seat, under the driving of screw mechanism, reaction liquid case lifting seat is carried
Reagent Tube group moves up and down.
Further, the intermediate plate that reaction includes being connected with installing plate with liquid case lifting seat, is arranged on intermediate plate both sides
Supporting plate, is provided with horizontal ends on supporting plate, be used to place buffering liquid case loading/unloading platform component.
Further, described pump valve pipe integrated unit includes pump valve integrated base plate, and pump valve integrated base plate includes compacted
Dynamic pump installing plate and fixed plate, the base plate of the connection of peristaltic pump installing plate, are arranged in sipper pore group and the base plate on base plate
Between control valve group part installing plate；
Peristaltic pump mounting hole is provided with peristaltic pump installing plate, two peristaltic pumps are set thereon；
Interval setting multiple reagent pipe clamps and wire clamp are gone back on base plate.
Further, described buffering liquid case loading/unloading platform component is the structure of drawing and pulling type, after setting reagent on platform,
Whole platform assembly is arranged in the casing of right side, when handling reagent is needed, platform is pulled out, and after placing, original is pushed back again
Position；
It includes carrier fluid platform, and it is an arm-tie with handle, and shakes hands to be fixed on handle plate；
The both sides of carrier fluid platform are provided with connecting plate, and horizontal part and the reaction of connecting plate are connected with the supporting plate of liquid case lifting seat
Connect；
In the presence of reaction is with liquid case lifting seat, carrier fluid platform moves up to the syringe needle suction pipe on the downside of pump valve integrated pipe
Place, through the control of control unit, selectively draws reagent.
Further, slide track component is set between described carrier fluid platform and the connecting plate of both sides, it makes carrier fluid platform
Moved along connecting plate.
Further, the sipper pore group on described base plate has been arranged side by side multiple holes, and syringe needle suction pipe passes through sipper pore, separately
One end connects Reagent Tube and is connected with the fluid path port of corresponding control valve；
Control valve group part is arranged on the center section of pump valve integrated base plate, and hydraulic pump is arranged on its sidepiece, in opposite side
Portion sets fluid path control unit, and fluid path control unit is isolated by a bending plate with fluid path part.
Beneficial effects of the present invention are compared with prior art：The box DNA sequencer that test solution of the invention is supplied automatically,
Storage, conveying, the selection of reagent are controlled by control unit；Liquid case hoistable platform component is moved reagent delivery extremely by guide rail
Specified location, it is easy to control, accurate；Liquid case hoistable platform is upper and lower by the gentle fliud flushing case loading/unloading platform component of the integrated tube assembly of pump valve
Transport, complete reagent conveying, course of reaction.
DNA sequencer of the present invention has the body structure of periphery, and sequencing reaction and agent delivery device should have stable, close
The operating environment closed；Overall structure stabilization, is sequenced efficiency high.Sequenator should have company during agent delivery, sequencing reaction
Continuous, controllable characteristic.
DNA sequencer of the invention has the robust structure of many recanalization, easy for installation between each structure, compact conformation,
Stability is high.Reaction warehouse component can be installed, fixed and adjust described reaction chip, it is ensured that environment of the reaction chip in stabilization
In reacted, also, reaction chip can conveniently take out and lock.
The present invention sets casing in the reaction warehouse component of DNA sequencing and the periphery of reagent component so that reaction warehouse has
The space of enough precision, stability and cleaning；Space is reasonable, be easily portable adjustment.
Casing is provided with left and right two parts space, and reaction component and agent delivery, storage assembly, left and right space are accommodated respectively
Interior equipment works respectively, forms streamlined operation, and testing efficiency is high.
The liquid-supplying system of DNA sequencer of the invention controls storage, conveying, the selection of reagent by control unit；Liquid case
Hoistable platform component is moved reagent delivery to specified location by guide rail, easy to control, accurate；Liquid case hoistable platform is by pump valve
The gentle fliud flushing case loading/unloading platform component of integrated tube assembly is transported up and down, completes reagent conveying, course of reaction.
Brief description of the drawings
Fig. 1 is the functional block diagram of DNA sequencer of the invention；
Fig. 2 a are the overall structure diagram of DNA sequencer casing of the invention；
Fig. 2 b are the first structure schematic diagram of the body supports component of DNA sequencer casing of the invention；
Fig. 2 c are the second structural representation of the body supports component of DNA sequencer casing of the invention；
Fig. 3 is the overall structure diagram of DNA sequencer reaction record subsystem of the invention；
Fig. 4 is the first dimensional structure diagram of reaction warehouse component of the invention；
Fig. 5 a are the first dimensional structure diagram of turnable warehouse of the invention；
Fig. 5 b are the second dimensional structure diagram of turnable warehouse of the invention；
Fig. 6 a are the dimensional structure diagram of locating piece of the invention；
Fig. 6 b are the structural representation of electronic lock of the invention；
Fig. 6 c are the structural representation of electronics lock of the invention；
Fig. 6 d are the cross section structure diagram of electronic lock of the invention；
Fig. 7 is cross section structure diagram of the turnable reaction warehouse component of the invention along first lug；
Fig. 8 is the 3rd dimensional structure diagram of turnable warehouse of the invention；
Fig. 9 a are the structural representation of reaction chip component of the invention；
Fig. 9 b are the structural representation of reaction chip mounting seat of the invention；
Fig. 9 c are the structural representation of the medial surface of reaction warehouse base of the invention；
Fig. 9 d are the structural representation of the lateral surface of reaction warehouse base of the invention；
Fig. 9 e are the structural representation of temperature control component cover plate of the invention；
Figure 10 a are the cross section structure diagram along liquid inlet and outlet of reaction chip component of the invention；
Figure 10 b are cross section structure diagram of the turnable reaction warehouse component of the invention along self-adaptative adjustment part；
Figure 11 is turnable reaction warehouse component cross section structure diagram of the invention；
Figure 12 a are the cross section structure diagram of back shroud of the invention；
Figure 12 b are the dimensional structure diagram of bonnet board component of the invention；
Figure 12 c are the dimensional structure diagram of back shroud of the invention；
Figure 13 a are the dimensional structure diagram of the top plate member of DNA sequencer casing of the invention；
Figure 13 b are the dimensional structure diagram of the left side storehouse trim panel assembly component of DNA sequencer casing of the invention；
Figure 14 a are the dimensional structure diagram of liquid case hoistable platform component of the invention；
Figure 14 b are the side structure schematic view of liquid case hoistable platform component of the invention；
Figure 15 a are the dimensional structure diagram of the integrated tube assembly of pump valve of the invention；
Figure 15 b are the overlooking the structure diagram of the integrated tube assembly of pump valve of the invention；
Figure 15 c are the structural representation of pump valve integrated base plate of the invention；
Figure 16 a are the dimensional structure diagram of buffering liquid case loading/unloading platform component of the invention；
Figure 16 b are the positive structure diagram of buffering liquid case loading/unloading platform component of the invention.
Specific embodiment
Below in conjunction with accompanying drawing, the technical characteristic above-mentioned and other to the present invention and advantage are described in more detail.
Refer to shown in Fig. 1, it is the functional block diagram of DNA sequencer casing of the invention, the DNA of the embodiment of the present invention is surveyed
Sequence instrument includes reaction record subsystem, agent delivery system and control system, and carries the sequenator casing of above-mentioned each system,
In the present embodiment, described reaction record subsystem and agent delivery system are separately positioned on the left and right sides of sequenator casing
In interval, and connected by the agent delivery pipeline being arranged in casing；Described set-up of control system is interval on the left of casing
The rear side of interior reaction record subsystem, control reaction subsystem and agent delivery system are acted according to predetermined sequential.
Described control system control agent delivery system reacts record point by reagent delivery to reaction record subsystem
Reaction warehouse component is provided with system, reagent flows through the reaction chip being arranged in reaction warehouse component and reacts, reaction record
CCD camera in subsystem gathers the photo in course of reaction and obtains surveyed DNA sequence dna after analysis.
Refer to shown in Fig. 2 a, it is the overall structure diagram of DNA sequencer casing of the invention, the embodiment of the present invention
Sequenator casing include body supports component 21, be arranged on the liner board component of the inner side of body supports component 21, offside door is total
Into component 23, offside door assembly component 26, buffering liquid case loading/unloading platform component 25, left side cover plate assembly 30, rear side cover plate assembly,
Upper cover plate 3110.
Described liner board component includes that left side storehouse interior finishing panel assembly 24, right side storehouse left side interior finishing panel assembly and right side storehouse are right
Side interior finishing panel assembly 22.
In embodiments of the present invention, casing is divided into left and right two parts, reaction record subsystem is provided with the casing of left side, i.e.,
Reaction warehouse component and CCD camera；Agent delivery system, including the lifting of pump valve pipe integrated unit, liquid case are provided with right case
Platform and display, are provided with control assembly on rear side of casing.Operationally, pump valve integrated unit by reagent solution according to suitable
Sequence is delivered in reaction warehouse component, completes chemical reaction, and under the control of the control unit, CCD camera completes to take pictures, and finally passes through
Cross data analysis to take pictures result, point draw a conclusion.
Wherein, the bottom of the supporting box of body supports component 21, sidepiece, rear portion and two segmentations of housing area in left and right
Portion；Plaque is provided with the two medial support components of housing area in left and right, plays heat-insulated and increase structural stability
Effect；In left side, the front portion of casing is provided with offside door assembly component 23, when offside door assembly component is opened, can be to being arranged on
Reaction warehouse component in left box body is operated；Offside door assembly component 26 is provided with the right side of the casing of right side, during opening, can
Pump valve integrated unit is operated, various reagents pipe and control valve road are set in the subregion.
Refer to shown in Fig. 2 b-2c, it is the structural representation of body supports component of the invention；The embodiment of the present invention
Body supports component is made up of steel plate splicing, is fixed by way of splicing or screw are fastened；It include base assembly 212,
Top plate member 2112, with the support frame assembly 211 that base assembly 212 connects and composes casing side frame, buffer system is installed
Seat 213.Wherein, described support frame assembly 211 includes left side vertical plate component 2116, separates the middle riser of left and right two tanks
Component 2115, right side riser component 2117 and it is arranged on the right side of right side riser forward portion and mends slab 2119, rear side riser
Component 2118, the first cable fixed seat 2113 being arranged in top plate member 2112 and the first cable fixed seat 2114, with
And the connecting plate 2133 that each component links together.
Wherein, described left side vertical plate component 2116, middle riser component 2115 surround the reaction for accommodating reaction warehouse component
Storehouse accommodating cavity 200；First cable fixed seat 2114 is set in top plate member, and left side casing is divided into the anti-of front side by the steel plate
Answer the circuit board accommodating cavity 20 of storehouse accommodating cavity 200 and rear side；Middle riser component 2115 and right side riser component 2117 surround examination
Agent chamber 2001.The middle steel plate of top plate member is provided with the first bending plate 2141 and the second bending plate 2142, both integrally into
The part that type, the respectively bending on the side of steel plate two are formed, forms between the first bending plate 2141 and the second bending plate 2142
Wire casing, passes through for wire.
Described buffer system mounting seat 213 includes being separately positioned on left side vertical plate component 2116 and middle riser component
Platform support panel 2132 and Reagent Tube support base 2131 on 2115, set platform group on described platform support panel 2132
Part and reaction warehouse component thereon.
Casing of the present invention is connected using plate, not only easy for installation, and the structural strength that each component links together
Height, can support the weight of reaction warehouse component, camera and pump valve integrated unit, and can provide stabilization, reliable environment.
Refer to shown in Fig. 3, it is the overall structure diagram of DNA sequencer reaction record subsystem of the invention, this
In inventive embodiments reaction record subsystem include reaction warehouse component 12, motion platform component 14, motion control unit 15,
CCD camera 101 and platform support component 13, wherein,
Described reaction warehouse component 12, sets reaction chip component in it, in the presence of control system, reaction solution enters
Chemically reacted in reaction chip, produced visible ray；Described motion platform component 14, be fed into CCD camera suitably by it
Picture-taking position, in reaction chip produce visible optical information carry out collection of taking pictures；Described platform component 13, its branch
Support described reaction warehouse component 12, motion platform component 14；Described motion control unit, it is to CCD camera and reaction core
The operation real-time control of piece.
In embodiments of the present invention, described reaction warehouse component 12 can be installed, fixed and adjust described reaction chip,
Ensure that reaction chip is reacted in the environment of stabilization, also, reaction chip can conveniently take out and lock.
Refer to shown in Fig. 4, described reaction warehouse component 12 includes being arranged on perpendicular on described platform component 13
The straight door frame 121 for setting, is provided with turnable reaction warehouse component 124, in turnable reaction warehouse on the top in the outside of door frame 121
The lower end of component 124 is connected with turnable basement 122, and turnable basement 122 is fixed on the middle part of door frame 121, may be reversed reaction
Storehouse component 124 can rotate around described turnable basement 122, be used to take out or be put into reaction chip.
Electronics lock set 125 is additionally provided with the left of the upper end of described door frame 121, only in electronics lock set 125
During opening, turnable reaction warehouse component 124 can be rotated, reaction chip is operated.In embodiments of the present invention, if
Door frame 121 is equipped with, reaction chip and dependency structure is supported, the stability of system is substantially increased.
May be reversed reaction warehouse component 124 includes may be reversed warehouse, is provided with the center section of described turnable warehouse
Back shroud 1242, is used to encapsulate Reagent Tube；Bottom is provided with the first rotating part, it includes the first accommodating chamber 1243, is used to hold
Receive turnable basement 122, the first accommodating chamber 1243 is arranged on the centre position of bottom；It is to be symmetrical arranged in the first accommodating chamber both sides
First lug 1244, have through hole 1246 in the middle setting of first lug 1244；To connect with described turnable basement 122
Connect.Turnable basement is rotated relative to turnable warehouse in the first accommodating chamber 1243, with stability higher, while ensureing examination
Agent and the transmission of data are unimpeded.Door frame 121 has the structure of sidepiece baffle plate 1211 for one side, and it is integrally formed.
Refer to shown in Fig. 4, the turnable basement 122 in the embodiment of the present invention has two companies of the second lug 1221
Base is connect, the second lug 1221 is symmetricly set on a side 1223 of base, and through hole 1224 is provided with the middle of it, with institute
The through hole 1246 of the middle setting of the first lug 1244 on turnable warehouse stated is co-axially mounted, also, the second lug 1221
Installed in the inner side of first lug 1244.
Incorporated by reference to shown in Fig. 2, in embodiments of the present invention, the both sides of described turnable basement 122 are arranged on sidepiece gear
In plate 1211 and contact positioning with sidepiece baffle plate 1211；Described first lug 1224 is co-axially mounted with the second lug 1221
Afterwards, the upper-end contact of end and turnable basement 122, also, may be reversed the sidepiece of warehouse and the sidepiece baffle plate 1211 of door frame 121
Medial surface is contacted, it is ensured that be may be reversed warehouse and is located just in sidepiece baffle plate 1211 with turnable basement 122.
Refer to shown in Fig. 5 a and 5b, reaction chip component be installed on the inside of the centre of described turnable warehouse,
Accordingly, there is the first cavity 1785 for accommodating reagent pipeline in the middle setting that may be reversed warehouse, at the bottom of the first cavity 1785
Portion is provided with first boss 1784, and first boss 1784 is used to the support member of the reaction chip component for carrying described, convex first
Platform 1784 is provided with four guide post mounting holes 1786, and guide post mounting hole 1786 passes through two ends, the reaction core that may be reversed warehouse
Piece component and support member, reaction chip component is connected with turnable warehouse；Set in the upper end of described first boss 1784
Second boss 1783 is equipped with, second boss 1784 is used to position described support member；Set in the described upper end of second boss 1784
Locating surface 1782 is equipped with, locking screw nail 1787 is provided with locating surface 1782.Described in above-mentioned first cavity body structure positioning
Reaction chip component, also, reaction chip component is in normal work, it is impossible to enough rotations, it is merely able to be moved along guide post.
The He of Reagent Tube mounting hole 1788 is provided with the upper surface of the first accommodating chamber 1243 of described turnable warehouse
Electric wire mounting hole, is provided with pipe clamp 03 in Reagent Tube mounting hole 1788, and being passed through in pipe clamp 03 has Reagent Tube 02 and electric wire 01.
The dead bolt of the dead bolt 1252 in the sidepiece of described turnable warehouse is additionally provided with electronics lock set 125 is installed
Hole；In the presence of locking member, may be reversed warehouse and be fixed together with door frame 121.
The upper end in the outside of described turnable warehouse is provided with pressing piece 1241, is only pressed by pressing piece 1241
Pressure is set can rotate described turnable warehouse.In embodiments of the present invention, incorporated by reference to shown in Fig. 8, described pressing
1241 one end of part are provided with the structure that opening 1730, one end is provided with hook, and described hook connects with the upper end-stopping plate of door frame
Connect, when pressing piece 1241 is subject to downward active force, hook departs from door frame baffle plate, and may be reversed reaction warehouse body can be with respect to door
Frame rotates.
In embodiments of the present invention, described pressing piece 1241 is arranged in a positioning block 1762, under locating piece 1762
End is provided with spring 1761, and spring is arranged in spring base 1763, and spring base 1763 is threadably mounted at and may be reversed reaction warehouse
In the spring base hole 1781 of the upper surface of intermediate throughholes 1785.
Incorporated by reference to shown in Fig. 5 b and 6a, locating piece 1762 is arranged on the locating piece installation cavity that may be reversed reaction warehouse upper end
In 1791, positioning step 1790 is provided with cavity.Locating piece 1762 in the embodiment of the present invention includes the He of upper through hole 1794
Lower through-hole 1797, one of both is by described pressing piece 1241；The side of locating piece set locating and machining hole 1796 and
Mounting hole 1795.The lower end of the through hole for installing pressing piece 1241 is provided with spring eye, spring is by the hole and pressing piece 1241
Bottom contact.
The embodiment of the present invention sets electronics lock set and pressing piece, and two are carried out to may be reversed reaction warehouse component and door frame
Secondary locking, is respectively adopted automatically controlled and mechanical structure mode, it is ensured that reaction chip runs in security context, it is to avoid maloperation.
Incorporated by reference to shown in Fig. 6 b and 6c, electronics lock set 125 of the invention includes electronics lock and inductive switch 1251, institute
The inductive switch stated is arranged on electronics lock, and electronics lock is arranged on the sidepiece of turnable warehouse, in embodiments of the present invention,
Electronics lock includes sidepiece installing plate 1843, and mounting hole 1844 is offered on sidepiece installing plate 1843；Electronic lock is made by peace
Dress hole 1844 and mounting screw are fixed on turnable warehouse.It is provided with the described side of sidepiece installing plate 1843 symmetrical
First framework 1841 and second framework 1842, the sky for installing inductive switch 1251 is left in the centre of the first framework and second framework
Between.
In embodiments of the present invention, described inductive switch 1251 includes being arranged on the framework 1255 of outside, framework 1255
One side on be provided with connection screw thread hole 1256, it is fixed with described electronics lock by attachment screw 1254；Described
Attachment screw 1254 is used to increase electronics lock by the framework 1841 of lug 1258 and first, second framework 1842 on side
Bonding strength.Control circuit 1252 is also associated with described inductive switch 1251, is used to carry out inductive switch 1251
Control.
Refer to shown in Fig. 6 d, described electronics lock set 125 is arranged on the sidepiece that may be reversed warehouse and door frame 121, lock
Tongue 1253 stretch out after enter be arranged in the dead bolt hole 1247 of turnable warehouse sidepiece, realize locking；When dead bolt 1253 is pierced in electricity
In the presence of swashing, when being retracted from dead bolt hole 1247 is interior, described turnable warehouse can be rotated.
The use of door frame, be not only able to cause reaction chip component Stability Analysis of Structures, and, also cause may be reversed warehouse with
Turnable basement compact conformation, is easy to operation；CCD camera is more accurate with the positioning of reaction chip.
The bottom of door frame 121 is provided with the first mounting hole 1210, to be connected with motion platform component 14；In door
Frame middle part is additionally provided with the second mounting hole being connected with turnable basement sidepiece.
Incorporated by reference to shown in Fig. 7, in embodiments of the present invention, in order to save structure space and ensure the steady of reagent delivery
It is fixed, it is provided with reagent in the through hole of the lug 1221 of through hole 1246 and second of the middle setting of described first lug 1244
The fixation kit of pipe first, it includes the pipe joint 1265, the first packing ring 1264, the first rotary shaft that are arranged in the lug of left side
1261, and reagent pipe joint 1266, second packing ring 1267, the second rotary shaft 1269 in the lug of right side are arranged on, wherein, institute
The first packing ring 1264 and second packing ring 1267 stated are arranged between turnable warehouse and turnable basement, in the present embodiment,
The diameter of the through hole 1246 of the middle setting of described first lug 1244 is less than the diameter of the through hole of the second lug 1221,
Both medial end forms the positioning rib to packing ring positioning, and after two packing rings are installed, inside diameter of gasket is just with second
The diameter of the through hole of lug 1221 is identical.Positioning rib and packing ring are set in embodiments of the present invention, it is ensured that may be reversed storehouse
Gapless between body and turnable basement, both good stabilities after combining will not be rocked because there is gap, also,
Packing ring increased both contacts area so that stress reduction between the two, extension device service life.
The first rotation is installed on the inside of the inner side of the through hole 1246 of the middle setting of first lug 1244 and packing ring
The rotary shaft 1269 of axle 1261 and second, the structure of two rotary shafts is identical, is the quill shaft with positioning convex ring；In rotary shaft
One end set positioning convex ring, connection screw thread hole is provided with, to the lug connection portion with described turnable warehouse
1263 are connected, and accordingly, the positioning recess for positioning the positioning convex ring are provided with the end of described through hole 1246.
The centre at the both ends of rotary shaft 1269 is recess, and inner side recess is used to and described pipe joint 1265, reagent pipe joint
1266 install positioning.Live wire and Reagent Tube 02 are respectively mounted in pipe joint 1265, reagent pipe joint 1266, its difference
Lead in reaction chip component.Due to the component that setting in the embodiment of the present invention can mutually overturn, in upset, to avoid to pipe
Part is impacted, and Reagent Tube is installed in through-holes, substantially increases the security performance of Reagent Tube.
Refer to shown in Fig. 8, in embodiments of the present invention, described reaction chip component is arranged on described turnable storehouse
The inner side of body.The observation portion 1724 contacted with CCD camera is provided with the inside of reaction chip component, is provided with transparent
Baffle plate, to be taken pictures to course of reaction.
Refer to shown in Fig. 9 a, reaction chip component of the invention includes reaction chip mounting seat 127, reaction warehouse base group
Part 126 and the shading positioning component 128 reaction warehouse base assembly 126 and reaction chip mounting seat 127 locked, is opened；For
Easily reaction chip can be taken out and closed, reaction chip mounting seat 127 can be relative with reaction warehouse base assembly 126
Rotation.
Refer to shown in Fig. 9 b, it is the structural representation of reaction chip mounting seat of the invention, installed in reaction chip
The center section of seat 127 is provided with reaction chip, and cover plate 1277 is provided with reaction chip；Installed in the both sides of reaction chip
There is chute pressing plate 1279, be used to be fixed reaction chip.A side portion of reaction chip mounting seat 127 is provided with installation
Seat supports component, it is used in taking-up or chip placement, the described reaction chip mounting seat of support；It includes torsional-spring supported portion
1273, it is arranged in mounting seat, it is used to support described torsion spring, described torsional-spring supported portion 1273 is for one with protruding end 1274
Recess, in the reaction chip mounting seat 127 described in rotation, protruding end 1274 contacts with 1261 at first, in the present embodiment,
Described protruding end 1274 is arranged on the middle part of recess and the edge of chip installation position；Using mounting seat structure in itself
Reaction chip mounting seat is supported, better reliability, it is ensured that chip can be safely removed and placed.
Described mounting seat support component also includes that torsion spring 1272 and torsion spring 1272 are connected and be arranged on the drawing at torsion spring two ends
Mandrel 1271, described tension axle 1271 is arranged on lug boss 1275, when reaction chip mounting seat is started, described torsion spring
1272 support mounting seats, and finally by the positioning of protruding end 1274, realize support.
Be additionally provided with the first rotary shaft hole 1276 in the end of described lug boss 1275, to reaction warehouse base 1261
Connection.Locating slot 1278 is additionally provided with the sidepiece of reaction chip mounting seat.
Refer to shown in Fig. 9 c, it is the structural representation of the medial surface of reaction warehouse base of the invention, in reaction warehouse
Reaction pond body 1266 is provided with medial surface, reaction tank 1267 is set in reaction pond body 1266 center section, in reaction tank 1267
Surrounding 1706 be provided with sealing ring, prevent reaction reagent from leaking.One end of reaction warehouse base 1261 is provided with raised line 1705,
To be positioned with the cover plate after installation.The other end is provided with the torsional-spring supported structure corresponding with reaction chip mounting seat, its
Including symmetrically arranged two protruding ends 1268, the second rotary shaft hole 1269 is provided with thereon, itself and the first rotary shaft hole
1276 is coaxial, and rotary shaft sequentially passes through holes；Region 1260 and the positioning region for torsion spring activity are additionally provided with the end
1707, the screwed hole 1712 being used to reaction Hatch Board is installed is provided with the region.
Refer to shown in Fig. 9 d, it is the structural representation of the lateral surface of reaction warehouse base of the invention, at reaction warehouse bottom
The center section of the lateral surface of seat is provided with temperature control component, and the center section of reaction warehouse base is provided with temperature sensor installs
Groove 1262, heating wire mounting groove 1704 is provided with the bottom of mounting groove 1262, and heating wire and temperature sensor are placed respectively.
A positioning boss 1703 is additionally provided with mounting groove, is positioned when it is used to be installed with temperature control component cover plate 1263.In temperature control group
Positioning recess 1702 corresponding with positioning boss 1703 is provided with part cover plate 1263.
The surrounding of temperature sensor mounting groove 1262 is provided with four guide post mounting holes 1742, is provided with upper and lower sides
Self adaptation spring mounting hole 1741；It is also equipped with being oriented to rod aperture 1701 on cover plate 1263.
Shading positioning component mounting groove 1265 is additionally provided with reaction warehouse base, is used to described shading positioning group is installed
Part 128, is provided with installation base 1744 in it.
Incorporated by reference to shown in Figure 10 a-10b, the middle part of reaction warehouse base is provided with electrical heating wire 1754, it is arranged on
In the heating wire mounting groove 1704 of base；TEMP is provided with the temperature sensor mounting groove 1262 on electrical heating wire top
Device 1720 and control assembly, are used to detect the temperature of reaction tank and the threshold value according to setting is adjusted；In temperature sensor
1720 and control assembly 1753 also pour and be inoculated with seal 1263, it is encapsulating resin.Examination is respectively arranged with the two ends of reaction tank
Agent pipe installs screwed hole 1721, to be connected with Reagent Tube；The end for installing screwed hole 1721 in Reagent Tube is provided with inlet
1723 and liquid outlet 1713, liquid inlet and outlet is communicated with the two ends of reaction tank, to cycle detection reagent.
The avris of the interior grooves of reaction tank is provided with sealing ring 1713.It is provided with the centre of reaction chip mounting seat
Reaction chip 04, reagent flows through reaction chip and reacts.
In embodiments of the present invention, the Reagent Tube mounting hole 1788 that Reagent Tube 02 passes through turnable warehouse, being arranged on to turn over
The middle setting of roll-over body has the first cavity 1785 for accommodating reagent pipeline, and final coupled reaction pond body, reagent cartridge passes through each
The sealing of cavity is planted, stability is high, is hardly damaged.
Back shroud 1242 is fixed with rear side of reaction warehouse, the middle setting of back shroud 1242 has self-adaptative adjustment part
1751, refer to shown in Figure 12 a-12c, there are two rows that raised line 1809 is installed in the inner side middle setting of back shroud 1242, installing
The middle setting of raised line 1809 has the first installation base 1812 and the second installation base 1811, and screw thread is offered on installation base
Hole 1802, self-adaptative adjustment part 1751 is arranged in the screwed hole 1802.
In embodiments of the present invention, described self-adaptative adjustment part 1751 is the end of thread with the connection end of back shroud, and anti-
The connection end for answering storehouse component is the polished rod 1805 for being provided with spring 1806, nut 1804 is provided between the ends and is positioned,
After installation is complete, nut 1804 is close to installation base.
It is passage 1803 between two described raised lines 1809, enables to Reagent Tube to pass through；Also set on back shroud
It is equipped with the reinforcement gusset 1812 vertical with raised line 1809；In raised line 1809 and the bit plane of upper surface 1810 of boss；In plate below
Peripheral framework 1807 centre and corner be provided with trip bolt hole 1801, to connect with described turnable reaction warehouse
Connect fixation.
Above-mentioned bonnet board component, is not only able to carry out face sealing to reaction warehouse component, additionally it is possible to installs fixed self adaptation and adjusts
One integral piece, simple structure.
In embodiments of the present invention, may be reversed between reaction warehouse and reaction warehouse base 126 and be provided with self-adaptative adjustment part
1751, the end spring of self-adaptative adjustment part 1751 and the end contact of reaction warehouse base；When being fed using CCD camera, phase
When machine is with reaction chip component touch, when camera position is adjusted, can be adjusted by the way of movable, it is now, adaptive
Answering adjustment part can change the position of reaction chip component according to the change in location of camera, it is ensured that with accuracy of detection higher,
Simultaneously, it is to avoid system is caused to damage.
Refer to shown in Figure 13 a-13b, top plate member 2112 in embodiments of the present invention, it include front side board 2124,
Right plate 2125, back side panel 2143, left plate 2153, are sequentially connected with successively between above-mentioned each plate, and each plate is bending
Plate, including vertical plate and level board, connection forms support section before and after vertical plate is arranged on the outside of level board, level board.
Intermediate plate 2123 is connected between the 2143 of front side board 2124 and back side panel, in intermediate plate 2123 and left plate 2153
Between be provided with division board 2128；Fluid path accommodating cavity is formed between intermediate plate 2123 and right plate 2143, in front side board 2124
Reaction warehouse accommodating cavity is formed and division board 2128 between.
In embodiments of the present invention, the upper end connection upper cover plate 3110 of top plate member 2112, in the vertical of right plate 2125
Portion is provided with integrally formed connection sheet 2151；The vertical portion of back side panel 2143 is provided with connecting plate 2133.
The wire casing being made up of its bending part, including rear side wire casing 2127 be set on intermediate plate 2123, and wire is from rear side line
Groove 2127 is passed through in reaction warehouse component by the first cable fixed seat 2114.It is front side connecting portion 2122 in front side, left side is
Left side connecting portion 2121, is threaded hole thereon, to be connected with upper cover plate；Left side is the first rear side connecting portion 2130, rear side
It is the second rear side connecting portion 2129；Lock 2150 is set on second rear side connecting portion 2129.
The edge of top board is provided with connecting portion 2152.
Trim panel assembly component in left side storehouse of the invention, it includes being arranged on first trim panel 241 and difference of centre
The both sides of the first trim panel 241 and the trim panel 243 of connected second trim panel 242 and the 3rd are arranged on, in the second trim panel
242 outside is also associated with the first interior trim and mends the interior trim of slab 244 and second benefit slab 245.
The agent delivery system of the embodiment of the present invention includes control unit, buffering liquid case loading/unloading platform component, liquid case lifting
The integrated tube assembly of platform assembly, pump valve, wherein, described buffering liquid case loading/unloading platform can load and unload various reagents, and by liquid
Case hoistable platform component is transported to the position specified up and down, and for described pump valve integrated pipe Component driver, the pump valve is integrated
The Reagent Tube that tube assembly selection needs, driving and the open and close controlling of hydraulic valve through hydraulic pump, by specified reagent delivery extremely
Reacted in reaction warehouse component；The action of above-mentioned each element is controlled by control unit unification.
The liquid case hoistable platform component of the embodiment of the present invention is the mechanism that pumps that motor leading screw drives, its installation
In the right side casing of sequenator.It includes that motor 401 and motor are connected and support the support base of motor
402 and motor connection lead screw assembly, the reaction liquid case lifting seat 408 installed in sidepiece, wherein, described reaction
Buffer solution case loading/unloading platform component is equiped with liquid case lifting seat 408 is interior, reaction is arranged on liquid case lifting seat 408 and reaction is used
On the installing plate 404 of liquid case lifting seat connection, under the driving of screw mechanism, reaction is carried with liquid case lifting seat Reagent Tube group
Lower motion.
The intermediate plate 4081 that reaction includes being connected with installing plate with liquid case lifting seat 408, is arranged on the support of intermediate plate both sides
Plate 4082, horizontal ends are provided with supporting plate 4082, are used to place buffering liquid case loading/unloading platform component.
The output shaft of described motor 401 is connected with leading screw 403, and leading screw is arranged in base 405, base 405 with
The end of motor 401 is connected by support base 402；The sidepiece of base 405 is provided with stroke detection switch 406.It is described
The output shaft of motor be connected with the connection end 4034 of leading screw by shaft coupling 4035；Nut 4031 is connected with leading screw,
Nut is fixed on nut seat 4032；Leading screw lower end is provided with bearing (ball) cover 4011 by bearings, bearing end.
The liquid case hoistable platform component of the embodiment of the present invention is moved reagent delivery to specified location, controlling party by guide rail
Just, precisely；Liquid case hoistable platform transports the gentle fliud flushing case loading/unloading platform component of the integrated tube assembly of pump valve up and down, completes reagent defeated
Give, course of reaction.
The integrated tube assembly of pump valve of the embodiment of the present invention is loaded and unloaded reagent from buffer solution case by the syringe needle suction pipe 507 of downside
Sucked in Reagent Tube on platform assembly, and by the selection of fluid path control unit 502, drive control valve module 509 and hydraulic pressure
Pump 506 is selected, and reagent is entered in reagent cartridge, carries out sequencing reaction.
The integrated tube assembly of described pump valve includes pump valve integrated base plate 508, and pump valve integrated base plate 508 includes peristaltic pump
Installing plate 5011 and fixed plate 5083, the base plate 5084 of the connection of peristaltic pump installing plate 5011, are arranged on the sipper pore group on base plate
5085 and base plate in the middle of control valve group part installing plate 5081；Peristaltic pump installation is provided with peristaltic pump installing plate 5011
Hole 5082, sets two peristaltic pumps 505 thereon；Interval setting multiple reagent pipe clamps and wire clamp 5015 are gone back on base plate 5084.
Accordingly, control valve group part 509 is arranged on the center section of pump valve integrated base plate 508, and hydraulic pump 506 is arranged on
Its sidepiece, fluid path control unit 502 is set in the other side, and fluid path control unit 502 is by a bending plate 503 and fluid path part
Isolation.
In embodiments of the present invention, in order to carry out sequencing reaction to plurality of reagents, the sipper pore group 5085 on base plate
Multiple holes are arranged side by side, syringe needle suction pipe 507 passes through sipper pore, the other end to connect the fluid path end of Reagent Tube and corresponding control valve
Mouth connection；Pipe clamp 5013 is set on sipper pore, prevents syringe needle suction pipe from inclining.
The embodiment of the present invention, using the integrated tube assembly of pump valve, can simultaneously select plurality of reagents, and according to pre-
The order for first setting carries out sequencing reaction, and testing efficiency is high.
Buffering liquid case loading/unloading platform component is the structure of drawing and pulling type, after setting reagent on platform, whole platform assembly peace
In the casing of right side, when handling reagent is needed, platform is pulled out, after placing, pushed home is put again.
It includes carrier fluid platform 310, and in the present embodiment, it is an arm-tie with handle 3101, and shakes hands to fix
On handle plate；The both sides of carrier fluid platform 310 are provided with connecting plate 311, and horizontal part and the reaction of connecting plate 311 are lifted with liquid case
The supporting plate connection of seat 408；In the presence of reaction is with liquid case lifting seat, carrier fluid platform 310 is moved up under pump valve integrated pipe
At the syringe needle suction pipe 507 of side, through the control of control unit, reagent is selectively drawn.
Slide track component 312 is set between described carrier fluid platform 310 and the connecting plate 311 of both sides, and it makes carrier fluid platform
Moved along connecting plate.
Above-mentioned detailed description is directed to illustrating for one of them possible embodiments of the present invention, and the embodiment is simultaneously not used to
The scope of the claims of the invention is limited, all equivalence enforcements or change without departing from carried out by the present invention are intended to be limited solely by the technology of the present invention
In the range of scheme.
Claims (6)
1. the box DNA sequenators that a kind of test solution is supplied automatically, it is characterised in that it includes reaction record subsystem, reagent
Supply system and control system, and carry the sequenator casing of above-mentioned each system, wherein, described reaction record subsystem and
Left and right two parts that agent delivery system is separately positioned on sequenator casing are interval interior, and supplied by the reagent being arranged in casing
Pipeline is answered to connect；The rear side of reaction record subsystem of the described set-up of control system in interval on the left of casing；
Agent delivery system, including buffering liquid case loading/unloading platform component, liquid case hoistable platform component, pump are provided with right case
The integrated tube assembly of valve；Wherein,
Described buffering liquid case loading/unloading platform can load and unload various reagents, and being transported to up and down by liquid case hoistable platform component
The position specified, for described pump valve integrated pipe Component driver, the Reagent Tube that the integrated tube assembly selection of pump valve needs, through liquid
The driving of press pump and the open and close controlling of hydraulic valve, will be reacted in specified reagent delivery to reaction warehouse component；
The reaction record subsystem, the action of agent delivery system are controlled by control unit unification；
Casing includes body supports component, is arranged on the liner board component on the inside of body supports component, body supports modular support
The bottom of casing, sidepiece, two cutting parts of housing area in rear portion and left and right；
Described liquid case hoistable platform component is the mechanism that pumps that motor leading screw drives, liquid case hoistable platform component peace
In the right side casing of sequenator；
Described liquid case hoistable platform component include motor and motor connect and support the support base of motor,
Lead screw assembly, the reaction liquid case lifting seat installed in sidepiece being connected with motor, wherein,
Buffer solution case loading/unloading platform component is equiped with described reaction liquid case lifting seat, reaction liquid case lifting seat is arranged on
On the installing plate being connected with reaction liquid case lifting seat, under the driving of screw mechanism, reaction liquid case lifting seat reagent is carried
Pipe group moves up and down.
2. the box DNA sequencer that test solution according to claim 1 is supplied automatically, it is characterised in that reaction liquid case liter
Drop seat includes the intermediate plate being connected with installing plate, is arranged on the supporting plate of intermediate plate both sides, and horizontal ends are provided with supporting plate, is used to put
Put buffering liquid case loading/unloading platform component.
3. the box DNA sequencer that test solution according to claim 1 is supplied automatically, it is characterised in that described pump valve pipe
Integrated unit includes pump valve integrated base plate, and pump valve integrated base plate includes that peristaltic pump installing plate and peristaltic pump installing plate are connected
Fixed plate, base plate, be arranged on the control valve group part installing plate in the middle of sipper pore group and base plate on base plate；
Peristaltic pump mounting hole is provided with peristaltic pump installing plate, two peristaltic pumps are set thereon；
Interval setting multiple reagent pipe clamps and wire clamp are gone back on base plate.
4. the box DNA sequencer that test solution according to claim 1 is supplied automatically, it is characterised in that described buffer solution
Case loading/unloading platform component is the structure of drawing and pulling type, and after setting reagent on platform, whole platform assembly is arranged in the casing of right side,
When handling reagent is needed, platform is pulled out, after placing, pushed home is put again；
It includes carrier fluid platform, and it is an arm-tie with handle, and shakes hands to be fixed on handle plate；
The both sides of carrier fluid platform are provided with connecting plate, and the horizontal part of connecting plate is connected with the supporting plate of reaction liquid case lifting seat；
In the presence of reaction is with liquid case lifting seat, carrier fluid platform is moved up at the syringe needle suction pipe on the downside of pump valve integrated pipe,
Through the control of control unit, reagent is selectively drawn.
5. the box DNA sequencer supplied automatically according to the test solution described in claim 4, it is characterised in that flat in described carrier fluid
Slide track component is set between platform and the connecting plate of both sides, it makes carrier fluid platform be moved along connecting plate.
6. the box DNA sequencer supplied automatically according to the test solution described in claim 3, it is characterised in that on described base plate
Sipper pore group has been arranged side by side multiple holes, and syringe needle suction pipe passes through sipper pore, the other end to connect Reagent Tube with corresponding control valve
Fluid path port connects；
Control valve group part is arranged on the center section of pump valve integrated base plate, and hydraulic pump is arranged on its sidepiece, is set in the other side
Fluid path control unit is put, fluid path control unit is isolated by a bending plate with fluid path part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510731398.0A CN105385590B (en) | 2015-11-02 | 2015-11-02 | The box DNA sequencer that a kind of test solution is supplied automatically |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510731398.0A CN105385590B (en) | 2015-11-02 | 2015-11-02 | The box DNA sequencer that a kind of test solution is supplied automatically |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105385590A CN105385590A (en) | 2016-03-09 |
| CN105385590B true CN105385590B (en) | 2017-05-31 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510731398.0A Expired - Fee Related CN105385590B (en) | 2015-11-02 | 2015-11-02 | The box DNA sequencer that a kind of test solution is supplied automatically |
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| Country | Link |
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| CN (1) | CN105385590B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102703312A (en) * | 2012-05-24 | 2012-10-03 | 中国科学院北京基因组研究所 | DNA (Deoxyribose Nucleic Acid) sequencer |
| CN102703302A (en) * | 2012-05-24 | 2012-10-03 | 中国科学院北京基因组研究所 | Installing seat for automatically clamping sequencing chip |
| CN102766574A (en) * | 2012-05-24 | 2012-11-07 | 中国科学院北京基因组研究所 | Reaction chamber for DNA sequenator |
| CN104266885A (en) * | 2014-07-25 | 2015-01-07 | 安徽省一一通信息科技有限公司 | Sample automatic-treatment system |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009022280A2 (en) * | 2007-08-14 | 2009-02-19 | Koninklijke Philips Electronics N.V. | Transport module of a single-cartridge diagnostic device |
-
2015
- 2015-11-02 CN CN201510731398.0A patent/CN105385590B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102703312A (en) * | 2012-05-24 | 2012-10-03 | 中国科学院北京基因组研究所 | DNA (Deoxyribose Nucleic Acid) sequencer |
| CN102703302A (en) * | 2012-05-24 | 2012-10-03 | 中国科学院北京基因组研究所 | Installing seat for automatically clamping sequencing chip |
| CN102766574A (en) * | 2012-05-24 | 2012-11-07 | 中国科学院北京基因组研究所 | Reaction chamber for DNA sequenator |
| CN104266885A (en) * | 2014-07-25 | 2015-01-07 | 安徽省一一通信息科技有限公司 | Sample automatic-treatment system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105385590A (en) | 2016-03-09 |
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Granted publication date: 20170531 Termination date: 20191102 |