CN105296328B - A kind of DNA sequencer reaction chip device - Google Patents

A kind of DNA sequencer reaction chip device Download PDF

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Publication number
CN105296328B
CN105296328B CN201510711543.9A CN201510711543A CN105296328B CN 105296328 B CN105296328 B CN 105296328B CN 201510711543 A CN201510711543 A CN 201510711543A CN 105296328 B CN105296328 B CN 105296328B
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CN
China
Prior art keywords
reaction
mounting seat
reaction chip
chip mounting
chip
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201510711543.9A
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Chinese (zh)
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CN105296328A (en
Inventor
冯玉臣
张睿
陈哲
范东雨
王者馥
王绪敏
殷金龙
任鲁风
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Beijing Zhongkezixin Technology Co Ltd
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Beijing Zhongkezixin Technology Co Ltd
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Priority to CN201510711543.9A priority Critical patent/CN105296328B/en
Publication of CN105296328A publication Critical patent/CN105296328A/en
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Publication of CN105296328B publication Critical patent/CN105296328B/en
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

The present invention relates to a kind of DNA sequencer reaction chip device, reaction chip assembly includes reaction chip mounting seat and reaction warehouse base assembly, reaction chip mounting seat can rotate against with reaction warehouse base assembly, and can stop in certain angle, to take out reaction chip and to place;Wherein, the mid portion in described reaction chip mounting seat is provided with described reaction chip, and the side portion in reaction chip mounting seat is provided with mounting seat and props up support component, and it is in order to taking out or during chip placement, the reaction chip mounting seat described in support;Described mounting seat is propped up support component and is included torsional-spring supported portion, arranges lobe at the two ends in torsional-spring supported portion, and connecting between two lobe has torsion spring.The DNA sequencer reaction chip device of the present invention includes the two parts linked together that can relatively overturn, and, certain angle can be fixed on after upset, be convenient for changing reaction chip, simple to operate, stabilized structure.

Description

A kind of DNA sequencer reaction chip device
Technical field
The present invention relates to DNA sequencing field, particularly relate to a kind of DNA sequencer reaction chip device.
Background technology
In DNA sequencing technical field, reaction chip assembly is as the core of tester, the side of its operation Just property is important index with the compactedness of structure.
Chinese patent of the prior art " for the reaction warehouse of DNA sequencer " discloses a kind of reaction warehouse knot Structure, it includes two parts cooperated, including reaction cell body and mounting seat, reaction cell body is provided with Annular groove, mounting seat is provided with through installation cavity, and installation cavity is provided with multiple locating slot, Mei Geding Being provided with in the groove of position slides stretches in installation cavity the slip hyoplastron with clamping sequence testing chip;Reaction cell body and the end The first elastomeric element it is provided with between Zuo.
When installing and change reaction chip, slip hyoplastron need to be unclamped and dismantle, it is impossible to enough realizations Continuous operation, dismounting inconvenience.
In view of drawbacks described above, creator of the present invention obtains this creation finally through research for a long time and practice.
Summary of the invention
It is an object of the invention to provide a kind of DNA sequencer reaction chip device, in order to overcome above-mentioned technology Defect.
For achieving the above object, the present invention provides a kind of DNA sequencer reaction chip device, reaction chip group Part includes reaction chip mounting seat and reaction warehouse base assembly, and reaction chip mounting seat can be with reaction warehouse base Assembly rotates against, and can stop in certain angle, to take out reaction chip and to place;
Also include the shading positioning component that reaction warehouse base assembly and reaction chip mounting seat are locked, opened;
Wherein, the mid portion in described reaction chip mounting seat is provided with described reaction chip, instead The side portion answering chip mounting seat is provided with mounting seat and props up support component, and it is in order to taking out or during chip placement, Reaction chip mounting seat described in support;
Described mounting seat is propped up support component and is included torsional-spring supported portion, arranges lobe at the two ends in torsional-spring supported portion, Connecting between two lobe and have torsion spring, under the drive of torsion spring, described reaction chip mounting seat rotates also Support navigates to certain angle;
In the medial surface of reaction warehouse base, it is provided with reaction cell body, reaction is set at reaction cell body mid portion Pond, reaction reagent, through reaction tank, reacts in reaction chip;
The torsional-spring supported knot corresponding with reaction chip mounting seat it is provided with in the end of described reaction warehouse base Structure, it includes symmetrically arranged two protruding ends;Be additionally provided with in this end the region movable for torsion spring and Region, location.
Further, described torsional-spring supported portion is the recess shape with protruding end, rotate described in anti- When answering chip mounting seat, protruding end at first with reaction warehouse base contacts;
Described protruding end is arranged on the middle part of recess and the edge of chip installation position.
Further, described lobe being provided with tension axle, the two ends of tension axle are connected with torsion spring, When starting reaction chip mounting seat, described torsional-spring supported reaction chip mounting seat, and finally rely on protruding end Location;
Be additionally provided with the first rotary shaft hole in the end of described lobe, in order to described reaction warehouse base Connect.
Further, two protruding ends of described reaction warehouse base are provided with the second rotary shaft hole, its Coaxial with the first rotary shaft hole, rotary shaft sequentially passes through holes.
Further, the bottom at described reaction tank is fixed with detectable temperature and maintains temperature of reagent Temperature control assembly;The mid portion of reaction warehouse base is provided with temperature sensor mounting groove, in the bottom of mounting groove It is provided with heating wire mounting groove, places heating wire and temperature sensor respectively;
A positioning boss it is additionally provided with, location when it is in order to install with the cover plate of temperature control assembly in mounting groove.
Further, be respectively arranged with at the two ends of reaction tank Reagent Tube install screwed hole, in order to Reagent Tube Connect;The end installing screwed hole at Reagent Tube is provided with inlet and liquid outlet, and liquid inlet and outlet is with anti- The two ends of Ying Chi communicate.
Further, described shading positioning component includes that the tip inside face with reaction chip mounting seat contacts Slidably positioning and locking block and be arranged on the turnable basement assembly of medial end of reaction warehouse base;Described Slidably positioning and locking block be connected with turnable basement assembly elasticity.
Further, the avris in the interior grooves of reaction tank is provided with sealing ring;Described sealing ring is six Limit shape, it includes outer rim and the first blend stop being arranged on opposite side and the second blend stop, the first blend stop and second Reagent is divided into three parts by blend stop, can change test area in test process.
Compared with prior art the invention have the benefit that the DNA sequencer reaction chip device of the present invention Including the two parts linked together that can relatively overturn, and, can be fixed on certain after upset Angle, is convenient for changing reaction chip, simple to operate, stabilized structure.
In reaction chip assembly, it is provided with mounting seat props up support component, support reaction chip mounting seat, use and turn round The structure of spring, simple in construction;
Between two coupling parts of reaction chip, it is provided with shading positioning component, locks and open reaction warehouse Assembly, simple in construction is the compactest.
Accompanying drawing explanation
Fig. 1 a is the structural representation of the reaction chip assembly of the present invention;
Fig. 1 b is the structural representation of the reaction chip mounting seat of the present invention;
Fig. 1 c is the structural representation of the medial surface of the reaction warehouse base of the present invention;
Fig. 1 d is the structural representation of the lateral surface of the reaction warehouse base of the present invention;
Fig. 1 e is the structural representation of the temperature control assembly cover plate of the present invention;
Fig. 2 a is the structural representation of the shading positioning component of the present invention;
Fig. 2 b is the first structural representation of the slidably positioning and locking block of the present invention;
Fig. 2 c is the second structural representation of the slidably positioning and locking block of the present invention;
Fig. 2 d is the structural representation of the turnable basement assembly of the present invention;
Fig. 2 e is the structural representation of the spring assembly of the present invention;
Fig. 3 a is the sectional structure schematic diagram along liquid inlet and outlet of the reaction chip assembly of the present invention;
Fig. 3 b is the turning reaction warehouse assembly sectional structure schematic diagram along self-adaptative adjustment part of the present invention;
Fig. 3 c is the turning reaction warehouse assembly sectional structure schematic diagram along guide post of the present invention;
Fig. 4 a is the structural representation of the sealing ring of the present invention;
Fig. 4 b is the sealing ring sectional structure schematic diagram of the present invention;
Fig. 4 c is the use view that the present invention observes the sealing ring of right side reaction chip.
Detailed description of the invention
Below in conjunction with accompanying drawing, to the present invention, above-mentioned and other technical characteristic and advantage are described in more detail.
Referring to Fig. 1 a show, the reaction chip assembly of the present invention includes reaction chip mounting seat 127, reaction warehouse Base assembly 126 and reaction warehouse base assembly 126 and reaction chip mounting seat 127 locked, opens Shading positioning component 128;In order to easily reaction chip is taken out and Guan Bi, reaction chip mounting seat 127 can rotate against with reaction warehouse base assembly 126.
Referring to Fig. 1 b show, it is the structural representation of reaction chip mounting seat of the present invention, at reaction chip The mid portion of mounting seat 127 is provided with reaction chip, is provided with cover plate 1277 on reaction chip;Instead The both sides answering chip are provided with chute pressing plate 1279, in order to be fixed reaction chip.Pacify at reaction chip One side portion of dress seat 127 is provided with mounting seat and props up support component, and it is in order to when taking-up or chip placement, to prop up Reaction chip mounting seat described in support;It includes torsional-spring supported portion 1273, is arranged in mounting seat, in order to prop up Torsion spring described in support, described torsional-spring supported portion 1273 is one with the recess of protruding end 1274, is rotating During described reaction chip mounting seat 127, protruding end 1274 contacts with reaction warehouse base 1261 at first.? In the present embodiment, described protruding end 1274 is arranged on the middle part of recess and the edge of chip installation position; Reaction chip mounting seat is supported by the structure using mounting seat itself, better reliability, it is ensured that chip energy Enough safely remove and place.
Described mounting seat is propped up support component and is also included that torsion spring 1272 is connected with torsion spring 1272 and is arranged on torsion spring two The tension axle 1271 of end, described tension axle 1271 is arranged in lobe 1275, is starting reaction chip During mounting seat, described torsion spring 1272 supports mounting seat, and finally relies on the location of protruding end 1274, real Now support.
Be additionally provided with the first rotary shaft hole 1276 in the end of described lobe 1275, in order to reaction warehouse at the bottom of Seat 1261 connects.Sidepiece in reaction chip mounting seat is additionally provided with locating slot 1278.
Referring to Fig. 1 c show, it is the structural representation of medial surface of reaction warehouse base of the present invention, in reaction The medial surface of storehouse base is provided with reaction cell body 1266, reaction tank is set at reaction cell body 1266 mid portion 1267, the surrounding 1706 at reaction tank 1267 is provided with sealing ring, prevents reaction reagent from leaking.In reaction One end of storehouse base 1261 is provided with raised line 1705, in order to install after cover plate location.Arrange at the other end Having the torsional-spring supported structure corresponding with reaction chip mounting seat, it includes symmetrically arranged two protruding ends 1268, it is provided with the second rotary shaft hole 1269 thereon, it is coaxial with the first rotary shaft hole 1276, rotary shaft Sequentially pass through holes;The region 1260 movable for torsion spring and region 1707, location it is additionally provided with in this end, It is provided with in this region in order to the screwed hole 1712 by installing reaction warehouse cover plate.
Referring to Fig. 1 d show, it is the structural representation of lateral surface of reaction warehouse base of the present invention, in reaction The mid portion of the lateral surface of storehouse base is provided with temperature control assembly, and the mid portion at reaction warehouse base is provided with Temperature sensor mounting groove 1262, is provided with heating wire mounting groove 1704 in the bottom of mounting groove 1262, point Fang Zhi heating wire and temperature sensor.In mounting groove, be additionally provided with a positioning boss 1703, its in order to Position when installing with temperature control assembly cover plate 1263.As shown in fig. le, temperature control assembly cover plate 1263 is arranged There is the positioning recess 1702 corresponding with positioning boss 1703.
Surrounding at temperature sensor mounting groove 1262 is provided with four guide post installing holes 1742, at upper and lower sides It is provided with self adaptation spring mounting hole 1741;Cover plate 1263 is also equipped with guide rod aperture 1701.
Reaction warehouse base is additionally provided with shading positioning component mounting groove 1265, in order to install described shading Positioning component 128, is within it provided with installation base 1744.
Referring to shown in Fig. 2 a, it is the structural representation of shading positioning component of the present invention, and it includes sliding Dynamic positioning and locking block 1281 and turnable basement assembly 1283, wherein, described slidably positioning and locking block Locking jaw 1282, after installation is complete, described slidably positioning and locking block 1281 it is provided with on 1281 Upper surface contacts with the medial surface of reaction chip mounting seat 127, and locking jaw 1282 is hooked on reaction chip and installs The outboard end of seat 127;Described turnable basement assembly 1283 is arranged on the medial end of reaction warehouse base, It is provided with screwed hole 1830.After installation is complete, at the bottom of described shading positioning component 128 and reaction warehouse Seat is fixed together, and when opening reaction chip mounting seat, outwards presses slidably positioning and locking block 1281, Under the action of the spring, slidably positioning and locking block 1281 is outward-dipping, and locking jaw 1282 is pacified with reaction warehouse Dress seat departs from, and under the effect of the torsion spring of reaction warehouse mounting seat end, reaction warehouse mounting seat overturns, can be to instead Chip is answered to be replaced.
Incorporated by reference to shown in Fig. 2 b, described slidably positioning and locking block 1281 includes the pressing being arranged on top The elastic locking assembly of plate 1823 and bottom homonymy, company convex under the mid portion of pressing plate 1823 is Junction 1821, it coordinates with described turnable basement assembly 1283.Incorporated by reference to shown in Fig. 2 c, described Elastic locking assembly includes symmetrically arranged first spring base the 1822, second spring base 1828, is arranged on two The first recess 1827 between spring base;Spring assembly, spring assembly it is respectively arranged with in two spring bases Including the upper spring card slot 1281 shown in Fig. 2 e, lower spring draw-in groove 1283, upper and lower two spring card slots surround Spring eye 1771, spring eye is shoulder hole, is provided with spring 1820 in it;Wherein, at upper spring card slot 1281 On be provided with external part, it arranges hook claw, in order to be connected with the end of described pressing plate 1823.
In embodiments of the present invention, spring base and the first recess isolated by continuous print vertical baffle 1826 and Becoming, both sides arrange vertical rib 1829;Elastic locking assembly is arranged on integrated with pressing plate first flat On plate 1825, it is vertically arranged with pressing plate 1823.
Refer to shown in Fig. 2 d, the slidably positioning and locking block 1281 in the embodiment of the present invention and the turning end Holder assembly 1283 can symmetrical coordinate, and is provided with the first projection 1832 in the centre of turnable basement, and it is with the One recess 1827 snaps together;It is provided with in the first projection 1832 both sides and can accommodate vertical baffle 1826 Space;Accordingly, the second recess of the spring base described in receiving it is provided with in the first projection 1832 lateral symmetry 1833, the second recess is surrounded by continuous print vertical edge 1834;Said structure is arranged on integrated second On flat board 1831;In use, spring assembly is pressed against in spring base, by slip positioning and locking block 1281 Snap together with turnable basement assembly 1283.
The embodiment of the present invention, arranges shading positioning component, is not only able to stable locking reaction chip, and When changing reaction chip, simple to operate, only need to press slip positioning and locking block 1281 and open, and without tearing open Unload reaction chip mounting seat, save the time.
Refer to, shown in Fig. 3 a and 3b, the middle part of reaction warehouse base be provided with electrical heating wire 1754, It is arranged in the heating wire mounting groove 1704 of base;Temperature sensor mounting groove on electrical heating wire top It is provided with temperature sensor 1720 in 1262 and controls assembly, in order to detect the temperature of reaction tank and according to setting Threshold value be adjusted;Also water be inoculated with sealing member 1263 in temperature sensor 1720 and control assembly 1753, It is encapsulating resin.
It is respectively arranged with Reagent Tube at the two ends of reaction tank and screwed hole 1721 is installed, in order to be connected with Reagent Tube; The end installing screwed hole 1721 at Reagent Tube is provided with inlet 1723 and liquid outlet 1713, into and out of Liquid mouth communicates with the two ends of reaction tank, in order to cycle detection reagent.
Avris in the interior grooves of reaction tank is provided with sealing ring 1713.Centre in reaction chip mounting seat Being provided with reaction chip 04, reagent flows through reaction chip and reacts.
In embodiments of the present invention, the Reagent Tube 02 Reagent Tube installing hole 1788 by turning warehouse, arrange Be provided with in the centre of turning warehouse accommodate reagent pipeline the first cavity 1785, final coupled reaction cell body, Reagent cartridge is through the sealing of various cavitys, and stability is high, is hardly damaged.
In embodiments of the present invention, in order to ensure that turning reaction warehouse assembly can be coaxial with reaction chip assembly Mobile, convenient adjustment, it is additionally provided with guide post 1758 between the two, refers to shown in Fig. 3 c, at reaction warehouse Arranging guiding rod aperture 1742 on base, arrange guide post installing hole on turning warehouse, guide post 1742 depends on Secondary through holes.Described guide post 1758 includes reaction warehouse locating flange 1757, in order to guide rod aperture 1742 location;Positioned by the end face of nut 1755 with guide post installing hole at the other end, between also set up There is pad 1756.
In embodiments of the present invention, in order to test the diverse location of reaction chip, employing can Change the sealing ring 1713 of test area;Referring to shown in Fig. 4 a-4c, described sealing ring 1713 is six limits Shape, it includes outer rim 1716 and is arranged on the first blend stop 1714 and the second blend stop 1715 of opposite side, Reagent is divided into three parts by one blend stop 1714 and the second blend stop 1715.In an embodiment, sidepiece rib And blend stop upper end be respectively the first protruding 1718 and second projection 1719, two projections make reagent exist Flowing in the range of restriction, reagent liquid inlet and outlet is arranged in the chamfering between two blend stops.Do not using During blend stop, reagent flows into inside whole sealing ring by the chamfering between two blend stops, now, it is possible to observe The reaction of whole reaction chip;When state as shown in fig. 4 a, the reaction between two blend stops can only be observed The region of chip;When state as illustrated in fig. 4 c, can only region on the right side of observing response chip.
The embodiment of the present invention uses foldable sealing ring, substantially increases the motility of reaction test, can root According to needs, reaction chip is sampled.
In embodiments of the present invention, when described reaction warehouse assembly 12 works, above-mentioned reaction chip assembly peace Be contained in turning reaction warehouse, install guide post 1758 and self-adaptative adjustment part 1751, and packaged after Cover plate;After turnable basement assembly 122 installation, being locked by electronic lock assembly and pressing piece can Upset reaction warehouse and door frame, and the reaction warehouse assembly 12 of installation is arranged on platform assembly On 13.
Above-mentioned detailed description is illustrating for one of them possible embodiments of the present invention, and this embodiment is also Being not used to limit the scope of the claims of the present invention, all equivalences done without departing from the present invention are implemented or change, all should It is contained in the range of technical solution of the present invention.

Claims (6)

1. a DNA sequencer reaction chip device, it is characterized in that, reaction chip assembly includes reaction chip mounting seat and reaction warehouse base assembly, and reaction chip mounting seat can rotate against with reaction warehouse base assembly, and can stop in certain angle, reaction chip is taken out and places;
Also include the shading positioning component that reaction warehouse base assembly and reaction chip mounting seat are locked, opened;
Wherein, the mid portion in described reaction chip mounting seat is provided with described reaction chip, and the side portion in reaction chip mounting seat is provided with mounting seat and props up support component, and it is in order to taking out or during chip placement, the reaction chip mounting seat described in support;
Described mounting seat is propped up support component and is included torsional-spring supported portion, arranges lobe at the two ends in torsional-spring supported portion, and connecting between two lobe has torsion spring, and under the drive of torsion spring, described reaction chip mounting seat rotates and supports and navigates to certain angle;
Being provided with reaction cell body in the medial surface of reaction warehouse base, arrange reaction tank at reaction cell body mid portion, reaction reagent, through reaction tank, reacts in reaction chip;
The end of described reaction warehouse base is provided with the torsional-spring supported structure corresponding with reaction chip mounting seat, and it includes symmetrically arranged two protruding ends;The region movable for torsion spring and region, location it is additionally provided with in this end;
Described torsional-spring supported portion is the recess shape with protruding end, rotate described in reaction chip mounting seat time, protruding end at first with reaction warehouse base contacts;
Described protruding end is arranged on the middle part of recess and the edge of chip installation position;
Described shading positioning component includes the turnable basement assembly of slidably positioning and locking block that the tip inside face with reaction chip mounting seat contacts and the medial end that is arranged on reaction warehouse base;Described slidably positioning and locking block is connected with turnable basement assembly elasticity.
DNA sequencer reaction chip device the most according to claim 1, it is characterised in that be provided with tension axle in described lobe, the two ends of tension axle are connected with torsion spring, when starting reaction chip mounting seat, described torsional-spring supported reaction chip mounting seat, and finally rely on the location of protruding end;
It is additionally provided with the first rotary shaft hole, in order to be connected with described reaction warehouse base in the end of described lobe.
DNA sequencer reaction chip device the most according to claim 2, it is characterised in that be provided with the second rotary shaft hole on two protruding ends of described reaction warehouse base, it is coaxial with the first rotary shaft hole, and rotary shaft sequentially passes through holes.
DNA sequencer reaction chip device the most according to claim 2, it is characterised in that be fixed with detectable temperature in the bottom of described reaction tank and maintain the temperature control assembly of temperature of reagent;The mid portion of reaction warehouse base is provided with temperature sensor mounting groove, is provided with heating wire mounting groove in the bottom of mounting groove, places heating wire and temperature sensor respectively;
A positioning boss it is additionally provided with, location when it is in order to install with the cover plate of temperature control assembly in mounting groove.
DNA sequencer reaction chip device the most according to claim 4, it is characterised in that be respectively arranged with Reagent Tube at the two ends of reaction tank and install screwed hole, in order to be connected with Reagent Tube;The end installing screwed hole at Reagent Tube is provided with inlet and liquid outlet, and liquid inlet and outlet communicates with the two ends of reaction tank.
DNA sequencer reaction chip device the most according to claim 2, it is characterised in that the avris in the interior grooves of reaction tank is provided with sealing ring;Described sealing ring is hexagon, and it includes that reagent is divided into three parts by outer rim and the first blend stop being arranged on opposite side and the second blend stop, the first blend stop and the second blend stop, can change test area in test process.
CN201510711543.9A 2015-10-28 2015-10-28 A kind of DNA sequencer reaction chip device Expired - Fee Related CN105296328B (en)

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CN105296328B true CN105296328B (en) 2016-09-14

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JP2018089559A (en) * 2016-11-30 2018-06-14 シスメックス株式会社 Specimen treatment device, specimen treatment method and specimen treatment chip
CN106939284A (en) * 2017-05-05 2017-07-11 京东方科技集团股份有限公司 Chip and gene order surveying method for gene sequencing
WO2020034143A1 (en) * 2018-08-16 2020-02-20 深圳华大智造科技有限公司 Handle device, positioning device, loading device and gene sequencer
CN109401941B (en) * 2018-11-15 2024-05-28 江苏苏博生物医学科技南京有限公司 Gene chip

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CN102703311A (en) * 2012-05-24 2012-10-03 中国科学院北京基因组研究所 Reaction bin for adaptive regulation of DNA (Deoxyribose Nucleic Acid) sequencer
CN102703312A (en) * 2012-05-24 2012-10-03 中国科学院北京基因组研究所 DNA (Deoxyribose Nucleic Acid) sequencer
CN102703302A (en) * 2012-05-24 2012-10-03 中国科学院北京基因组研究所 Installing seat for automatically clamping sequencing chip
CN102766574A (en) * 2012-05-24 2012-11-07 中国科学院北京基因组研究所 Reaction chamber for DNA sequenator

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102703314A (en) * 2012-05-24 2012-10-03 中国科学院北京基因组研究所 Control system for DNA (Deoxyribose Nucleic Acid) sequencer
CN102703311A (en) * 2012-05-24 2012-10-03 中国科学院北京基因组研究所 Reaction bin for adaptive regulation of DNA (Deoxyribose Nucleic Acid) sequencer
CN102703312A (en) * 2012-05-24 2012-10-03 中国科学院北京基因组研究所 DNA (Deoxyribose Nucleic Acid) sequencer
CN102703302A (en) * 2012-05-24 2012-10-03 中国科学院北京基因组研究所 Installing seat for automatically clamping sequencing chip
CN102766574A (en) * 2012-05-24 2012-11-07 中国科学院北京基因组研究所 Reaction chamber for DNA sequenator

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