CN102666860A - 反向遗传*** - Google Patents
反向遗传*** Download PDFInfo
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- CN102666860A CN102666860A CN2010800419180A CN201080041918A CN102666860A CN 102666860 A CN102666860 A CN 102666860A CN 2010800419180 A CN2010800419180 A CN 2010800419180A CN 201080041918 A CN201080041918 A CN 201080041918A CN 102666860 A CN102666860 A CN 102666860A
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16151—Methods of production or purification of viral material
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- C—CHEMISTRY; METALLURGY
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16251—Methods of production or purification of viral material
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- C12N2800/00—Nucleic acids vectors
- C12N2800/24—Vectors characterised by the absence of particular element, e.g. selectable marker, viral origin of replication
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- C12N2830/00—Vector systems having a special element relevant for transcription
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- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims (16)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510264548.1A CN104862335A (zh) | 2009-07-31 | 2010-07-30 | 反向遗传*** |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27315109P | 2009-07-31 | 2009-07-31 | |
US61/273,151 | 2009-07-31 | ||
PCT/IB2010/002137 WO2011012999A1 (en) | 2009-07-31 | 2010-07-30 | Reverse genetics systems |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510264548.1A Division CN104862335A (zh) | 2009-07-31 | 2010-07-30 | 反向遗传*** |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102666860A true CN102666860A (zh) | 2012-09-12 |
CN102666860B CN102666860B (zh) | 2015-06-17 |
Family
ID=43018886
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201080041918.0A Active CN102666860B (zh) | 2009-07-31 | 2010-07-30 | 反向遗传*** |
CN201510264548.1A Pending CN104862335A (zh) | 2009-07-31 | 2010-07-30 | 反向遗传*** |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510264548.1A Pending CN104862335A (zh) | 2009-07-31 | 2010-07-30 | 反向遗传*** |
Country Status (9)
Country | Link |
---|---|
US (2) | US9821052B2 (zh) |
EP (1) | EP2459722B1 (zh) |
JP (3) | JP2013500712A (zh) |
KR (1) | KR20120039047A (zh) |
CN (2) | CN102666860B (zh) |
AU (1) | AU2010277310B2 (zh) |
CA (1) | CA2769673A1 (zh) |
HK (1) | HK1175814A1 (zh) |
WO (1) | WO2011012999A1 (zh) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105142667A (zh) * | 2013-01-23 | 2015-12-09 | 诺华股份有限公司 | 流感病毒重配 |
CN107667175A (zh) * | 2015-03-27 | 2018-02-06 | 卡迪拉保健有限公司 | 基于重组腮腺炎病毒jeryl lynn 2的疫苗 |
US10232031B2 (en) | 2013-03-13 | 2019-03-19 | Seqirus UK Limited | Influenza virus reassortment |
CN110305854A (zh) * | 2019-07-18 | 2019-10-08 | 山东中医药大学 | 一种携带荧光素酶的重组h3n2亚型流感病毒、构建方法及应用 |
CN114040979A (zh) * | 2019-06-21 | 2022-02-11 | 国立大学法人大阪大学 | 稳定地保持外源基因的人工重组rna病毒的制作方法 |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101323582B1 (ko) * | 2011-03-17 | 2013-10-30 | 충북대학교 산학협력단 | Vero 세포 유래의 polⅠ 프로모터 및 이를 포함하는 재조합 벡터 |
WO2013101783A2 (en) | 2011-12-30 | 2013-07-04 | Bio-Rad Laboratories, Inc. | Methods and compositions for performing nucleic acid amplification reactions |
EP2820126B1 (en) | 2012-03-02 | 2017-05-17 | Seqirus UK Limited | Influenza virus reassortment |
BR112015012380A2 (pt) | 2012-12-03 | 2017-09-12 | Novartis Ag | vírus influenza recombinante |
US20140274806A1 (en) | 2013-03-15 | 2014-09-18 | Synthetic Genomics Vaccines | Influenza virus reassortment |
WO2014145261A2 (en) * | 2013-03-15 | 2014-09-18 | University Of Maryland | Methods and compositions for in vivo immune stimulation and antigen production |
DE202013005130U1 (de) | 2013-06-05 | 2013-09-10 | Novartis Ag | Influenza Virus Reassortierung |
DE202013005100U1 (de) | 2013-06-05 | 2013-08-26 | Novartis Ag | Influenza Virus Reassortierung |
EP3004332A2 (en) | 2013-06-06 | 2016-04-13 | Novartis AG | Influenza virus reassortment |
US10726110B2 (en) * | 2017-03-01 | 2020-07-28 | Seven Bridges Genomics, Inc. | Watermarking for data security in bioinformatic sequence analysis |
MX2022006005A (es) | 2019-11-18 | 2022-10-27 | Seqirus Pty Ltd | Metodo para producir virus de la influenza reagrupados. |
CN114395568A (zh) * | 2021-10-29 | 2022-04-26 | 扬州大学 | 一种猪流行性腹泻病毒感染性cDNA克隆及其构建方法与应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101302499A (zh) * | 2008-06-30 | 2008-11-12 | 中国科学院广州生物医药与健康研究院 | 一种流感病毒疫苗种子株的制备方法 |
WO2009000891A2 (en) * | 2007-06-27 | 2008-12-31 | Avir Green Hills Biotechnology Research Development Trade Ag | Linear expression constructs for production of influenza virus particles |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0832638B2 (ja) | 1989-05-25 | 1996-03-29 | カイロン コーポレイション | サブミクロン油滴乳剤を含んで成るアジュバント製剤 |
WO1995011700A1 (en) | 1993-10-29 | 1995-05-04 | Pharmos Corp. | Submicron emulsions as vaccine adjuvants |
DE19612967A1 (de) | 1996-04-01 | 1997-10-02 | Behringwerke Ag | Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren |
DE19612966B4 (de) | 1996-04-01 | 2009-12-10 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren |
TW570803B (en) | 1997-04-09 | 2004-01-11 | Duphar Int Res | Influenza vaccine |
US6274147B1 (en) * | 1998-03-31 | 2001-08-14 | University Of Maryland-Biotechnology Institute | Method for generating nonpathogenic infectious pancreatic necrosis virus (IPNV) from synthetic RNA transcripts |
AU771110B2 (en) | 1998-06-12 | 2004-03-11 | Mount Sinai School Of Medicine Of The City University Of New York, The | Novel methods and interferon deficient substrates for the propagation of viruses |
DE69937999T2 (de) | 1998-06-12 | 2009-01-29 | Avir Green Hills Biotechnology Research Development Trade Ag | Interferon induzierende genetisch veränderte attenuierte viren |
GB9916794D0 (en) * | 1999-07-16 | 1999-09-22 | Isis Innovation | In vitro virus reconstitution |
EP1878424A3 (en) | 1999-09-24 | 2008-04-09 | GlaxoSmithKline Biologicals S.A. | Novel vaccine |
AU3604201A (en) | 2000-03-03 | 2001-09-12 | Chemo Sero Therapeut Res Inst | Cell usable in serum-free culture and suspension culture and process for producing virus for vaccine by using the cell |
WO2001083794A2 (en) | 2000-04-28 | 2001-11-08 | St. Jude Children's Research Hospital | Dna transfection system for the generation of infectious influenza virus |
AU2001264802A1 (en) * | 2000-05-21 | 2001-12-03 | University Of North Carolina At Chapel Hill | Assembly of large viral genomes and chromosomes from subclones |
GB0024089D0 (en) | 2000-10-02 | 2000-11-15 | Smithkline Beecham Biolog | Novel compounds |
WO2002074336A2 (en) | 2001-02-23 | 2002-09-26 | Glaxosmithkline Biologicals S.A. | Influenza vaccine formulations for intradermal delivery |
US20040096463A1 (en) | 2001-02-23 | 2004-05-20 | Nathalie Garcon | Novel vaccine |
TWI228420B (en) | 2001-05-30 | 2005-03-01 | Smithkline Beecham Pharma Gmbh | Novel vaccine composition |
EP1534845A1 (en) * | 2002-09-04 | 2005-06-01 | Polymun Scientific Immunbiologische Forschung GmbH | Generation of recombinant influenza virus using baculovirus delivery vector |
KR20070008625A (ko) | 2004-04-05 | 2007-01-17 | 화이자 프로덕츠 인코포레이티드 | 미세유체화된 수중유 유화액 및 백신 조성물 |
WO2005113756A1 (en) | 2004-05-14 | 2005-12-01 | Glaxosmithkline Biologicals S.A. | Method |
CN101094915A (zh) | 2004-05-20 | 2007-12-26 | 益得生物医学公司 | 生产流感疫苗的方法 |
MX2007005818A (es) * | 2004-11-19 | 2007-07-20 | Wisconsin Alumni Res Found | Vectores recombinantes de la influenza con unidades de transcripcion en tandem. |
JP5414178B2 (ja) | 2004-12-23 | 2014-02-12 | メディミューン,エルエルシー | ウイルス増殖用の非腫瘍形成性mdck細胞株 |
US7959930B2 (en) | 2004-12-24 | 2011-06-14 | Abbott Biologicals B.V. | Rescue of influenza virus |
FR2884255B1 (fr) | 2005-04-11 | 2010-11-05 | Vivalis | Utilisation de lignees de cellules souches aviaires ebx pour la production de vaccin contre la grippe |
BRPI0612268A2 (pt) | 2005-06-21 | 2009-01-27 | Medimmune Vaccines Inc | Ácido nucleico isolado, vetor de expressço, mÉtodos para produzir um rna genâmico da influenza, para produzir um vÍrus da influenza recombinante, para gerar um vÍrus de rna segmentado de filamento negativo recombinante nas cÉlulas caninas cultivadas e para gerar partÍculas virais da influenza infecciosa em cÉlulas caninas cultivadas, cÉlula, e, vÍrus |
US8703095B2 (en) | 2005-07-07 | 2014-04-22 | Sanofi Pasteur S.A. | Immuno-adjuvant emulsion |
CN101365480B (zh) | 2005-11-01 | 2014-11-05 | 诺华疫苗和诊断有限两合公司 | 经由β-丙内酯处理的残留细胞DNA水平降低的细胞衍生病毒疫苗 |
FR2896162B1 (fr) | 2006-01-13 | 2008-02-15 | Sanofi Pasteur Sa | Emulsion huile dans eau thermoreversible |
WO2007124327A2 (en) | 2006-04-19 | 2007-11-01 | Medimmune Llc. | Methods and compositions for expressing negative-sense viral rna in canine cells |
KR101151202B1 (ko) | 2006-10-12 | 2012-06-11 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 수중유 에멀젼 애주번트를 포함하는 백신 |
WO2008068631A2 (en) | 2006-12-06 | 2008-06-12 | Novartis Ag | Vaccines including antigen from four strains of influenza virus |
WO2009048885A2 (en) | 2007-10-08 | 2009-04-16 | Synthetic Genomics, Inc. | Assembly of large nucleic acids |
EP2233568A1 (en) * | 2009-03-19 | 2010-09-29 | Avir Green Hills Biotechnology Research Development Trade AG | Novel method for generation of RNA virus |
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2010
- 2010-07-30 CN CN201080041918.0A patent/CN102666860B/zh active Active
- 2010-07-30 CN CN201510264548.1A patent/CN104862335A/zh active Pending
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009000891A2 (en) * | 2007-06-27 | 2008-12-31 | Avir Green Hills Biotechnology Research Development Trade Ag | Linear expression constructs for production of influenza virus particles |
CN101302499A (zh) * | 2008-06-30 | 2008-11-12 | 中国科学院广州生物医药与健康研究院 | 一种流感病毒疫苗种子株的制备方法 |
Non-Patent Citations (1)
Title |
---|
GABRIELE NEUMANN等: "Generation of influenza A viruses entirely from cloned cDNAs", 《PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCE OF THE UNITED STATES OF AMERICA》, vol. 96, no. 16, 3 August 1999 (1999-08-03), pages 9345 - 9350 * |
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CN105142667A (zh) * | 2013-01-23 | 2015-12-09 | 诺华股份有限公司 | 流感病毒重配 |
US10232031B2 (en) | 2013-03-13 | 2019-03-19 | Seqirus UK Limited | Influenza virus reassortment |
CN111334530A (zh) * | 2013-03-13 | 2020-06-26 | 诺华股份有限公司 | 乙型流感病毒重配 |
US10864264B2 (en) | 2013-03-13 | 2020-12-15 | Seqirus UK Limited | Influenza virus reassortment |
CN107667175A (zh) * | 2015-03-27 | 2018-02-06 | 卡迪拉保健有限公司 | 基于重组腮腺炎病毒jeryl lynn 2的疫苗 |
CN114040979A (zh) * | 2019-06-21 | 2022-02-11 | 国立大学法人大阪大学 | 稳定地保持外源基因的人工重组rna病毒的制作方法 |
CN114040979B (zh) * | 2019-06-21 | 2024-06-28 | 国立大学法人大阪大学 | 稳定地保持外源基因的人工重组rna病毒的制作方法 |
CN110305854A (zh) * | 2019-07-18 | 2019-10-08 | 山东中医药大学 | 一种携带荧光素酶的重组h3n2亚型流感病毒、构建方法及应用 |
CN110305854B (zh) * | 2019-07-18 | 2023-09-15 | 山东中医药大学 | 一种携带荧光素酶的重组h3n2亚型流感病毒、构建方法及应用 |
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JP2017189179A (ja) | 2017-10-19 |
CA2769673A1 (en) | 2011-02-03 |
EP2459722A1 (en) | 2012-06-06 |
AU2010277310B2 (en) | 2015-01-15 |
JP2013500712A (ja) | 2013-01-10 |
JP2016019547A (ja) | 2016-02-04 |
US10610584B2 (en) | 2020-04-07 |
US20180236058A1 (en) | 2018-08-23 |
AU2010277310A1 (en) | 2012-02-23 |
US20120270321A1 (en) | 2012-10-25 |
JP6666311B2 (ja) | 2020-03-13 |
KR20120039047A (ko) | 2012-04-24 |
WO2011012999A1 (en) | 2011-02-03 |
CN104862335A (zh) | 2015-08-26 |
CN102666860B (zh) | 2015-06-17 |
HK1175814A1 (zh) | 2013-07-12 |
US9821052B2 (en) | 2017-11-21 |
EP2459722B1 (en) | 2017-09-06 |
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