CN104435554B - Treat the Chinese medicine composition of hepatitis B - Google Patents

Treat the Chinese medicine composition of hepatitis B Download PDF

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CN104435554B
CN104435554B CN201410766010.6A CN201410766010A CN104435554B CN 104435554 B CN104435554 B CN 104435554B CN 201410766010 A CN201410766010 A CN 201410766010A CN 104435554 B CN104435554 B CN 104435554B
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hepatitis
chinese medicine
medicine composition
japonicum
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唐爱国
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Abstract

The present invention discloses a kind of Chinese medicine composition for treating hepatitis B, belongs to hepatitis B medicine field.It is by 68 grams of Cynanchum glaucescens by weight, 50 60 grams of isatis root, 12 27 grams of Lygodium japonicum, 15 20 grams of Asiatic plantain, 4 10 grams of asarum, 10 20 grams of cuneate lespedeza herb with root, 6 10 grams of rush, 55 70 grams of oldenlandia diffusa, 40 55 grams of hypericum japonicum, 8 14 grams of felwort, 6 14 grams of safflower, return 12 20 grams of tail, 12 20 grams of grass-leaved sweetflag, play both sides of the street 8 12 grams, 25 35 grams of Sculellaria barbata, 15 25 grams of giant knotweed, 30 40 grams of desmodium waits composition, it is more effective to treating hepatitis B, it is more sensitive, it is almost without any side effects, by to man, female patient is distinguished by medication according to physilogical characteristics, improve curative effect, protect body.

Description

Treat the Chinese medicine composition of hepatitis B
Technical field
The present invention relates to a kind of Chinese medicine composition, more particularly to a kind of pharmaceutical composition for treating hepatitis B big and small three Yang.
Background technology
Chronic hepatitis B (abbreviation hepatitis B) refers to hepatitis B test positive, and the course of disease exceedes half a year or date of the onset not Clearly and clinic has chronic hepatitis shower.Clinical manifestation is the symptoms such as weak, sitophobia, nausea, abdominal distension, hepatalgia.Hepatomegaly, Quality is medium hardness, there is light tenderness.State of an illness severe one can with chronic liver disease face, spider angioma, liver palms, splenomegaly, liver function Exception or persistent anomaly.Slight, moderate and severe are divided into according to clinical manifestation.Traditional Chinese medical science hepatitis B on dialectical is referred to as：Hypochondriac pain, Huang Subcutaneous ulcer, tympanites.Its disease type can be divided into stagnation of liver qi, liver blood silt resistance, liver and gallbladder damp-heat, four kinds of deficiency and exhaustion of liver-YIN.
Existing hepatitis B treatment by Chinese herbs medicine also has much, but not satisfactory because of reasons such as curative effect, side effects, and lacks The effect of complete information is with long-term follow-up, stabilization, medication is not distinguish between for man, female patient according to physilogical characteristics. Sum it up, the research of hepatitis B is always one problem to shoulder heavy responsibilities of medical field with treatment.
The content of the invention
The technical problems to be solved by the invention are：It is an object of the invention to provide a kind of Chinese medicine group of new treatment hepatitis B Compound, it is more effective to treating hepatitis B, more sensitive, almost without any side effects, by being added to man, female patient according to physilogical characteristics To distinguish medication, curative effect, protection body are improved.
The present invention proposes a kind of Chinese medicine composition for treating hepatitis B, and it is made up of following bulk drugs：
4-8 grams of Cynanchum glaucescens, 50-70 grams of Radix Isatidis, 12-27 grams of Lygodium japonicum, 15-20 grams of Asiatic plantain,
4-10 grams of asarum, 10-20 grams of cuneate lespedeza herb with root, 6-10 grams of rush, 55-70 grams of oldenlandia diffusa,
40-55 grams of hypericum japonicum, 8-14 grams of felwort, 6-14 grams of safflower, 12-20 grams of Radix Angelicae Sinensis tail,
12-20 grams of grass-leaved sweetflag, play both sides of the street 8-12 grams, 25-35 grams of Sculellaria barbata, 15-25 grams of giant knotweed,
30-40 grams of desmodium, 18-25 grams of Rhizoma Schizocapsae Plantagineae, 10-15 grams of Herba Andrographitis, 10-15 grams of the bighead atractylodes rhizome,
10-15 grams of Chinese yam, 20-40 grams of achyranthes aspera；
When treatment target is women, 12-20 grams of saururus chinensis is added.
Preferably, it is made up of following bulk drugs：
5 grams of Cynanchum glaucescens, 55 grams of Radix Isatidis, 15 grams of Lygodium japonicum, 16 grams of Asiatic plantain,
5 grams of asarum, 15 grams of cuneate lespedeza herb with root, 8 grams of rush, 60 grams of oldenlandia diffusa,
45 grams of hypericum japonicum, 10 grams of felwort, 8 grams of safflower, 15 grams of Radix Angelicae Sinensis tail,
15 grams of grass-leaved sweetflag, play both sides of the street 10 grams, 30 grams of Sculellaria barbata, 20 grams of giant knotweed,
35 grams of desmodium, 20 grams of Rhizoma Schizocapsae Plantagineae, 12 grams of Herba Andrographitis, 12 grams of the bighead atractylodes rhizome,
12 grams of Chinese yam, 30 grams of achyranthes aspera.
Decoction, tablet, granule, capsule or pill is made after preparing in it.
The effect of main Chinese medicine being previously mentioned in above-mentioned technical proposal and effect are as follows：
Cynanchum glaucescens：Lowering the adverse-rising QI to resolve phlegm, cough-relieving, for coughing with a lot of sputum, asthma.The moral character is micro- warm but not dry strong, is longer than eliminating the phlegm, drops lung Gas is with flat cough and asthma.
Radix Isatidis：With clearing heat and detoxicating, cool blood, ecchymose removing, relieving sore-throat, there is anti-inflammation, relieve pain, bring down a fever and other effects, mainly Treatment for the illness such as warm heat disease heating, headache, laryngalgia, carbuncle sore tumefacting virus.
Lygodium japonicum：It is clearing heat and detoxicating, promoting diuresis for stranguria, for controlling urinary tract infections, lithangiuria, gonorrhoea, leukorrhea, hepatitis.
Asiatic plantain：Reducing fever and causing diuresis, cool blood, removing toxic substances, for bladder heat stagnation, difficult urination, under stranguria with turbid discharge band, summer-heat and damp rush down dysentery, urine Blood, the hot hot eyes of liver, abscess of throat, carbuncle sore tumefacting virus.
Asarum：There are wind-dispelling, cold dispelling, warm lung, water-filling, the effect having one's ideas straightened out；Anemofrigid headache is controlled, nasosinusitis, dentalgia, phlegm and retained fluid cough is inverse, Arthralgia pain due to rheumatism.
Cuneate lespedeza herb with root：Filling liver kidney, beneficial lung yin, eliminating stasis to subdue swelling, improving eyesight, diuresis is antipyretic, treats jaundice, relaxing tendons and activating collaterals.
Rush：Clearing heart fire, inducing diuresis for treating strangurtia；Hemostasis, ventilation, dissipate and swell, quench the thirst, control five leaching.
Oldenlandia diffusa：Clearing heat and detoxicating, dampness removing disappears carbuncle, anticancer；For malignant tumour, acute appendicitis, abscess of throat, damp and hot Huang Subcutaneous ulcer, difficult urination, sore furuncle poison, venomous snake bite, dyspnea and cough due to lung-heat etc..
Hypericum japonicum：Clearing heat and promoting diuresis, subdhing swelling and detoxicating；Control catarrhal jaundice, rush down dysentery, child convulsion, infantile malnutrition due to digestive disturbances or intestinalparasites, tonsillitis, acute appendicitis, furuncle It is swollen, snake bite.
Felwort：Heat-clearing and damp-drying drug, purging the liver of pathogenic fire is calmed the frightened；For jaundice with damp-heat pathogen；Urine leaching pain；Swelling of vulva pruritus vulvae；Under humid tropics；Liver and gall The alliteration headache of excess fire；Red eye, swell pain；Deaf ear swells；Hypochondriac pain bitter taste；Pyreticosis convulsion.
Safflower：Invigorate blood circulation, stasis eliminatings analgesic, moisturizes, and relieves pain.
Return tail：Promoting blood circulation and breaking stagnation, menstruction regulating and pain relieving.
Grass-leaved sweetflag：Qi-regulating, promoting blood circulation, wind is dissipated, is dried, dampness elimination appetizing, slit phlegm of having one's ideas straightened out, inducing resuscitation intelligence development；For gastral cavity ruffian is not hungry, keep silent Mouth diarrhea, coma epilepsy, ambition is unhappy, has a stomachache, stomachache, wind-cold-dampness arthralgia, swollen ulcer drug, traumatic injury.
Play both sides of the street：Dispelling, collateral-activating, Li Shui stimulates the menstrual flow；For joint pain, numbness contracture, oedema turgor, the few Amenorrhea of breast.
Sculellaria barbata：Heat-clearing, removing toxic substances, dissipate the stasis of blood, hemostasis, analgesic therapy；Haematemesis is controlled, bleeding from five sense organs or subcutaneous tissue, blood strangury, dysentery characterized by blood in the stool, jaundice, is had sore throat, Lung carbuncle, furunculosis, scrofula, sore, cancerous swelling, bruise knife wound, snake bite.
Giant knotweed：Wind-dispelling, dampness removing, broken stasis of blood, stimulate the menstrual flow；Control rheumatism arthralgia and myalgia, jaundice with damp-heat pathogen, injury from falling down.
Desmodium：Promoting diuresis for stranguria；It is clearing heat and detoxicating；Eliminating stasis to subdue swelling.Cure mainly liver and gall and stone in urinary system；Heat gonorrhea；Nephritic dropsy； Jaundice with damp-heat pathogen；Sore carbuncle swells；Venomous snake bite；Traumatic injury.
Rhizoma Schizocapsae Plantagineae：It is clearing heat and detoxicating, cough-relieving apophlegmatic, regulating qi-flowing for relieving pain, dissipate stasis of blood hemostasis；For cold, fever；Phlegm-heat cough；One hundred days Cough；Abdominal distention；Diarrhea dysentery abdominal pain；Infantile malnutrition；Hepatitis；Abscess of throat, traumatic injury.
Herba Andrographitis：There are clearing heat and detoxicating, anti-inflammatory, swelling and pain relieving effect.For multi-infection disease, including trauma infection contamination, Furuncle, carbuncle, erysipelas, the infection of the upper respiratory tract, acute and chronic tonsillitis, icterohepatitis.
The bighead atractylodes rhizome：Tonifying spleen, beneficial stomach, eliminating dampness, and in, it is antiabortive；Control deficient QI of the spleen and stomach, do not feel like eating, the few gas of burnout, empty swollen, diarrhea, Phlegm and retained fluid, oedema, jaundice, arthritis with fixed pain caused by dampness.
Chinese yam：Tonifying spleen nourishing the stomach, engender liquid and benefic lung, the puckery essence of kidney tonifying.For spleen eating less, endless diarrhea, the deficiency syndrome of the lung is breathed with cough, and kidney deficiency is lost Essence, abnormal heat are quenched one's thirst.
Achyranthes aspera：Carcinoma product poison is by silt eliminating impediment, resistance numbness pain of becoming silted up；Anti-inflammatory diuresis.
Saururus chinensis：Eliminating dampness and heat, subside a swelling, removing toxic substances；Harness the river swollen, tinea pedis, jaundice, stranguria with turbid discharge, with, carbuncle swells, treat poison.
The beneficial effects of the invention are as follows：Prescription of the present invention with felwort, giant knotweed, oldenlandia diffusa, hypericum japonicum, saururus chinensis, Sculellaria barbata, Herba Andrographitis are main ingredient, can effectively kill hepatitis viruse in human body, eliminate the symptoms such as hepatomegaly, repair damaged liver Tissue, repair liver function；With Radix Angelicae Sinensis, safflower, Radix Isatidis, asarum, grass-leaved sweetflag, Cynanchum glaucescens, play both sides of the street as ministerial drug so that present invention tool Have the effect of promoting blood circulation and removing blood stasis, qi-regulating is sensible, analgesic, it is antiviral；With cuneate lespedeza herb with root, rush, desmodium, Lygodium japonicum, the bighead atractylodes rhizome, Chinese herbaceous peony Grass, Rhizoma Schizocapsae Plantagineae, achyranthes aspera are adjuvant, have alleviate long-pending dissipating bind, anti-inflammatory diuresis, promoting diuresis for stranguria, strengthening the spleen and stomach, strengthen immunologic function, repair The effect of mending legion；And saururus chinensis have in terms of women leukorrhea and eruptive disease, menstruation regulating is controlled it is effective, add prescription in play protection Female genital system, the effect of anti-inflammatory menstruation regulating.The collaboration of this prescription compatibility, simplify efficient, through focus, quick acting.
This medicine has promoting blood circulation and removing blood stasis, anti-inflammatory diuresis, detumescence, clearing heat and detoxicating effect, especially to bacillary, viral second Liver, jaundice, liver enlargement have obvious therapeutic effect, no obvious toxic-side effects.
Clinical test situation：
2010 to 2014, this prescription was treated in 94 patients, wherein 7 acute hepatitis b companions altogether through clinical trial Jaundice, 87 are chronic hepatitis B.
7 acute hepatitis b treatments：Wherein 5 through taking this medicine 2 months, jaundice symptom is completely eliminated, and liver function is extensive Multiple normal, wherein 2 are taken this medicine 3 months, jaundice symptom is completely eliminated, and liver function recovery is normal.
87 are treating chronic hepatitis B situation：All cases are chronic hepatitis B acute exacerbation between 2005 to 2010, are passed through After the hospitalization state of an illness is recovered, continue the patient of treat-and-release and simple Office visits.Wherein male 51, women 36, its In 31 have slight jaundice, 22 liver enlargements, accessible liver and (or) a spleen, the liver enzyme rise of all patients and in normal upper limit 5 times within, wherein 79 hepatitis B virus DNA (DNA) tests positives.31 Patients with Jaundice serum bilirubins In 34.48 μm of ol/L or so；61 A/G are normal, 26 ＜ 1: 1.5, decoct concoction through taking this product, 1 month is 1 course for the treatment of, often Day take 2 times, monthly check liver function, 54 (accounting for 62%) liver function recovery in treatment 1-2 months is normal, and symptom improves；33 Example (accounting for 38%) liver function recovery in 3-5 months, 31 slight jaundice serum bilirubin in 2 months recover normal, and 79 Example hepatitis B virus DNA (has 64 to turn out cloudy, negative conversion rate is up to 81% in DNA tests positive patient.
Illustrated below for clinical practice of the present invention：
Example one：Patient Tang so-and-so, female, 21 years old this year, group of stone forward market town Lu Tang villages of Dongan County the 6th, because of chronic "small three positive" Clothes invention decocts one course for the treatment of of concoction, is checked after being discontinued 1 month for the first time, and checked secondary again in 1 year, HBV-DNA turns out cloudy, Liver function, B ultrasound and AFP etc. are normal, and virus has been removed,
Example two：Patient's money so-and-so, man, 31 years old this year, the 9th group of Lingling District rich family's bridge town water Sound-of-water-splashing villages, great three positive, clothes the present invention Three courses for the treatment of of concoction are decocted, is checked after 1 first quarter moon that is discontinued for the first time, checked secondary again in 1 year, HBV-DNA turns out cloudy, liver function Energy, B ultrasound and AFP etc. are normal.
Example three：Patient Mr. Li, male, in 49 years old this year, Lingling District postal kiosk country fair town cove edge of the village dam group, great three positive, clothes are originally Invention decocts 4 courses for the treatment of of concoction, is checked after being discontinued 1 month for the first time, checked secondary again in 1 year, HBV-DNA turns out cloudy, liver function Energy, B ultrasound and AFP etc. are normal.
Embodiment
Embodiment one
Take the Chinese medicine material of following mass parts：
5 grams of Cynanchum glaucescens, 55 grams of Radix Isatidis, 15 grams of Lygodium japonicum, 16 grams of Asiatic plantain,
5 grams of asarum, 15 grams of cuneate lespedeza herb with root, 8 grams of rush, 60 grams of oldenlandia diffusa,
45 grams of hypericum japonicum, 10 grams of felwort, 8 grams of safflower, 15 grams of Radix Angelicae Sinensis tail,
15 grams of grass-leaved sweetflag, play both sides of the street 10 grams, 30 grams of Sculellaria barbata, 20 grams of giant knotweed,
35 grams of desmodium, 20 grams of Rhizoma Schizocapsae Plantagineae, 12 grams of Herba Andrographitis, 12 grams of the bighead atractylodes rhizome,
12 grams of Chinese yam, 30 grams of achyranthes aspera；When treatment target is women, 15 grams of saururus chinensis is added.
Whole raw materials in addition to asarum are placed in ceramic vessel, add a certain amount of water, wait water to open rear 5-10 minutes again Add asarum, secondary, each 250 milliliters of decoction decocted with conventional mild and heavy respiration, by the decoction of secondary filter mix daily Dosage.Asarum, which decocts, then to discharge harmful substance too long too long, thus is put into after wanting.By the mixed of above-mentioned secondary filter Close liquid to divide equally into two, taken twice sooner or later per bu, every 30 days are a course for the treatment of, take the 1-2 course for the treatment of, the need being in a bad way The 3-5 course for the treatment of.
Each raw material of the present embodiment may also be fabricated which tablet, granule, capsule, oral liquid or pill after preparation.
Embodiment two
Take the Chinese medicine material of following mass parts：
6 grams of Cynanchum glaucescens, 60 grams of Radix Isatidis, 20 grams of Lygodium japonicum, 18 grams of Asiatic plantain,
8 grams of asarum, 18 grams of cuneate lespedeza herb with root, 7 grams of rush, 65 grams of oldenlandia diffusa,
50 grams of hypericum japonicum, 12 grams of felwort, 10 grams of safflower, 16 grams of Radix Angelicae Sinensis tail,
16 grams of grass-leaved sweetflag, play both sides of the street 12 grams, 28 grams of Sculellaria barbata, 22 grams of giant knotweed,
38 grams of desmodium, 22 grams of Rhizoma Schizocapsae Plantagineae, 14 grams of Herba Andrographitis, 14 grams of the bighead atractylodes rhizome,
14 grams of Chinese yam, 25 grams of achyranthes aspera；When treatment target is women, 13 grams of saururus chinensis is added.
The decoction of the present embodiment and method of administration are the same as embodiment one.
Embodiment three
Take the Chinese medicine material of following mass parts：
7 grams of Cynanchum glaucescens, 65 grams of Radix Isatidis, 25 grams of Lygodium japonicum, 18 grams of Asiatic plantain,
10 grams of asarum, 12 grams of cuneate lespedeza herb with root, 9 grams of rush, 68 grams of oldenlandia diffusa,
52 grams of hypericum japonicum, 13 grams of felwort, 12 grams of safflower, 18 grams of Radix Angelicae Sinensis tail,
18 grams of grass-leaved sweetflag, play both sides of the street 12 grams, 32 grams of Sculellaria barbata, 24 grams of giant knotweed,
40 grams of desmodium, 24 grams of Rhizoma Schizocapsae Plantagineae, 15 grams of Herba Andrographitis, 15 grams of the bighead atractylodes rhizome,
15 grams of Chinese yam, 35 grams of achyranthes aspera；When treatment target is women, 17 grams of saururus chinensis is added.
The decoction of the present embodiment and method of administration are the same as embodiment one.
The preferred embodiments of the present invention are these are only, are not intended to limit the scope of the invention, it is every to utilize this hair The equivalent structure transformation that bright description is made, or other related technical areas are directly or indirectly used in, it is included in In the scope of patent protection of the present invention.

Claims (3)

1. a kind of Chinese medicine composition for treating hepatitis B, it is characterised in that it is made up of following bulk drugs：
4-8 grams of Cynanchum glaucescens, 50-60 grams of Radix Isatidis, 12-27 grams of Lygodium japonicum, 15-20 grams of Asiatic plantain,
4-10 grams of asarum, 10-20 grams of cuneate lespedeza herb with root, 6-10 grams of rush, 55-70 grams of oldenlandia diffusa,
40-55 grams of hypericum japonicum, 8-14 grams of felwort, 6-14 grams of safflower, 12-20 grams of Radix Angelicae Sinensis tail,
12-20 grams of grass-leaved sweetflag, play both sides of the street 8-12 grams, 25-35 grams of Sculellaria barbata, 15-25 grams of giant knotweed,
30-40 grams of desmodium, 18-25 grams of Rhizoma Schizocapsae Plantagineae, 10-15 grams of Herba Andrographitis, 10-15 grams of the bighead atractylodes rhizome,
10-15 grams of Chinese yam, 20-40 grams of achyranthes aspera；
When treatment target is women, 12-20 grams of saururus chinensis is added.
2. the Chinese medicine composition for the treatment of hepatitis B according to claim 1, it is characterised in that it is made up of following bulk drugs：
5 grams of Cynanchum glaucescens, 55 grams of Radix Isatidis, 15 grams of Lygodium japonicum, 16 grams of Asiatic plantain,
5 grams of asarum, 15 grams of cuneate lespedeza herb with root, 8 grams of rush, 60 grams of oldenlandia diffusa,
45 grams of hypericum japonicum, 10 grams of felwort, 8 grams of safflower, 15 grams of Radix Angelicae Sinensis tail,
15 grams of grass-leaved sweetflag, play both sides of the street 10 grams, 30 grams of Sculellaria barbata, 20 grams of giant knotweed,
35 grams of desmodium, 20 grams of Rhizoma Schizocapsae Plantagineae, 12 grams of Herba Andrographitis, 12 grams of the bighead atractylodes rhizome,
12 grams of Chinese yam, 30 grams of achyranthes aspera.
3. the Chinese medicine composition for the treatment of hepatitis B according to claim 1, it is characterised in that decoction, piece is made after preparing in it Agent, granule, capsule or pill.
CN201410766010.6A 2014-08-19 2014-12-04 Treat the Chinese medicine composition of hepatitis B Expired - Fee Related CN104435554B (en)

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* Cited by examiner, † Cited by third party
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CN1634548A (en) * 2004-11-23 2005-07-06 北京亚东生物制药有限公司 Medicine composition for treating viral hepatitis and its preparation method
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Publication number Priority date Publication date Assignee Title
CN1634548A (en) * 2004-11-23 2005-07-06 北京亚东生物制药有限公司 Medicine composition for treating viral hepatitis and its preparation method
CN101695562A (en) * 2009-11-05 2010-04-21 蚌埠丰原涂山制药有限公司 Chinese medicinal composition for treating viral hepatitis and preparation method thereof

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