CN102579839A - Pharmaceutical preparation for treating diabetes and preparation method of same - Google Patents
Pharmaceutical preparation for treating diabetes and preparation method of same Download PDFInfo
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- CN102579839A CN102579839A CN2012100737023A CN201210073702A CN102579839A CN 102579839 A CN102579839 A CN 102579839A CN 2012100737023 A CN2012100737023 A CN 2012100737023A CN 201210073702 A CN201210073702 A CN 201210073702A CN 102579839 A CN102579839 A CN 102579839A
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Abstract
The invention discloses a pharmaceutical preparation for treating diabetes and a preparation method of the pharmaceutical preparation. Through a large number of experiments and researches, researchers develop a pharmaceutical composition composed of eight traditional Chinese medicines, namely mulberry leaves, boxthorn fruit, bitter gourd, milk vetch, dendrobe, dioscorea opposita, kudzuvine root and purslane, and prepare the pharmaceutical composition into granules. The preparation provided by the invention has a remarkable function of lowering blood sugar.
Description
Affiliated technical field
The invention belongs to medical technical field, be specifically related to a kind of pharmaceutical preparation of treating diabetes and preparation method thereof.
Background technology
Diabetes (diabetes) are to act on that body causes hypoinsulinism, insulin resistant etc. and a series of metabolism disorder syndromes such as the sugar that causes, protein, fat, power and water Xie Zhi by inherited genetic factors, immunologic function disorder, infected by microbes and toxin thereof, free radical toxin, Nervous and Mental Factors or the like various virulence factors; Be main feature clinically with the hyperglycemia; Performance such as polyuria, polydipsia, polyphagia can appear in model case, become thin; I.e. " three-many-one-little " symptom; Diabetes (blood glucose) cause complication in case control bad meeting, cause the depleted pathological changes at positions such as kidney, eye, foot, and can't cure.
" diabetes " are the diseases of the easy overheap of glucose in a kind of blood.The another name of giving it abroad is " reticent killer " (Silent Killer), particularly " adult diabetes mellitus ", and it is high especially that the middle age more than 40 years old is caught rate, and diabetes itself are also brought misery very to the people.It lets the people usually think that xerostomia wants to drink water, because of polyuria is repeatedly waken up midnight.Still feel hunger sensation although eaten many foods, lose weight, drowsiness or the like.By the time in the time of can feeling the obvious situation in somewhere, the state of an illness of diabetes has developed into to a certain degree.And fearful complication is also developing at whole body thereupon stealthily everywhere.
In these complication, what occurrence rate was the highest is retinopathy, nephropathy and neurological disorder, is called as three big complication of diabetes ".This three big complication has 80 percent people to be bound to such an extent that suffer from these diseases in patient of diabetes is given birth to back 20 years.Arteriosclerosis is also included within the inside, and this is because the disastrous effect that superfluous glucose corrodes whole body organ and tissue thereof gradually in the blood.In case suffer from diabetes, the trouble of human body arrives with it, because immunologic function weakens, infects by flu, pneumonia, caused various the catching of pulmonary tuberculosis easily, and is difficult for curing.And can optionally destroy cell, phagocyte.The defensive enginery of anticancer cell will weaken greatly, to making active, the gathering of cancerous cell, causes causing carninomatosis and suffers from.The complication scope that diabetes cause is disease so widely, and is almost rarely found except diabetes.Because the relation of complication, so got diabetes in case there is the people to say, the life-span deducts 10 years at least.
Research worker of the present invention is developed the pharmaceutical composition of being made up of Folium Mori, Fructus Lycii, Fructus Momordicae charantiae, the Radix Astragali, Herba Dendrobii, RHIIZOMA DIOSCOREAE frOm Henan of China, Radix Puerariae, Herba Portulacae eight flavor Chinese medicines through secular experimentation, and it is prepared into granule.Preparation of the present invention has significant hypoglycemic activity.
Summary of the invention
Research worker of the present invention is through lot of experiments; Develop the pharmaceutical composition of forming by Folium Mori, Fructus Lycii, Fructus Momordicae charantiae, the Radix Astragali, Herba Dendrobii, RHIIZOMA DIOSCOREAE frOm Henan of China, Radix Puerariae, Herba Portulacae eight flavor Chinese medicines; And said composition is prepared into granule, said composition has significant blood sugar reducing function.
The object of the present invention is to provide a kind of pharmaceutical composition of treating diabetes.
The objective of the invention is to further provide the method for preparing of this medicament composition granule agent.
The present invention realizes through following technical scheme:
Pharmaceutical composition of the present invention is formed:
Folium Mori, Fructus Lycii, Fructus Momordicae charantiae, the Radix Astragali, Herba Dendrobii, RHIIZOMA DIOSCOREAE frOm Henan of China, Radix Puerariae, Herba Portulacae
Pharmaceutical composition amount ranges of the present invention:
Folium Mori 10-30g, Fructus Lycii 5-15g, Fructus Momordicae charantiae 10-30g, Radix Astragali 5-15g, Herba Dendrobii 2-6g, RHIIZOMA DIOSCOREAE frOm Henan of China 10-30g, Radix Puerariae 5-15g, Herba Portulacae 2-8g
Pharmaceutical composition consumption optimum of the present invention:
Folium Mori 20g, Fructus Lycii 10g, Fructus Momordicae charantiae 20g, Radix Astragali 10g, Herba Dendrobii 4g, RHIIZOMA DIOSCOREAE frOm Henan of China 20g, Radix Puerariae 10g, Herba Portulacae 5g
The method for preparing of medicament composition granule agent of the present invention:
RHIIZOMA DIOSCOREAE frOm Henan of China, Herba Dendrobii are mixed pulverizing, cross 100 mesh sieves, get medicated powder, subsequent use; With the Radix Astragali, Folium Mori, Fructus Lycii, Fructus Momordicae charantiae, Radix Puerariae, the medicinal residues of Herba Portulacae and RHIIZOMA DIOSCOREAE frOm Henan of China and Herba Dendrobii mix, decocte with water 2 times, 6-10 times of water for the first time, 4-8 times of water for the second time, collecting decoction filters, and leaves standstill, and is subsequent use; Extracting solution is concentrated into 4L, extracts 50 ℃ of concentrated solutions, vacuum 0.10MPa drying under reduced pressure to moisture is pulverized below 5%, and is subsequent use; The dry powder that crushes is added the 1100G dextrin mix, cross 100 mesh sieves, the ethanol system soft material with 85%, 20 mesh sieves are granulated, and 14 mesh sieve granulate promptly get granule after 60 ℃ of oven dry.
The specific embodiment
Embodiment 1
1. pharmaceutical composition consumption:
Folium Mori 20g, Fructus Lycii 10g, Fructus Momordicae charantiae 20g, Radix Astragali 10g, Herba Dendrobii 4g, RHIIZOMA DIOSCOREAE frOm Henan of China 20g, Radix Puerariae 10g, Herba Portulacae 5g
2. method for preparing
RHIIZOMA DIOSCOREAE frOm Henan of China, Herba Dendrobii are mixed pulverizing, cross 100 mesh sieves, get medicated powder, subsequent use; With the Radix Astragali, Folium Mori, Fructus Lycii, Fructus Momordicae charantiae, Radix Puerariae, the medicinal residues of Herba Portulacae and RHIIZOMA DIOSCOREAE frOm Henan of China and Herba Dendrobii mix, decocte with water 2 times, 8 times of water for the first time, 6 times of water for the second time, collecting decoction filters, and leaves standstill, and is subsequent use; Extracting solution is concentrated into 4L, extracts 50 ℃ of concentrated solutions, vacuum 0.10MPa drying under reduced pressure to moisture 5% is pulverized, and is subsequent use; The dry powder that crushes is added the 1100G dextrin mix, cross 100 mesh sieves, the ethanol system soft material with 85%, 20 mesh sieves are granulated, and 14 mesh sieve granulate promptly get granule after 60 ℃ of oven dry.
Embodiment 2
1. pharmaceutical composition consumption:
Folium Mori 10g, Fructus Lycii 5g, Fructus Momordicae charantiae 10g, Radix Astragali 5g, Herba Dendrobii 2g, RHIIZOMA DIOSCOREAE frOm Henan of China 10g, Radix Puerariae 5g, Herba Portulacae 2g
2. method for preparing
RHIIZOMA DIOSCOREAE frOm Henan of China, Herba Dendrobii are mixed pulverizing, cross 100 mesh sieves, get medicated powder, subsequent use; With the Radix Astragali, Folium Mori, Fructus Lycii, Fructus Momordicae charantiae, Radix Puerariae, the medicinal residues of Herba Portulacae and RHIIZOMA DIOSCOREAE frOm Henan of China and Herba Dendrobii mix, decocte with water 2 times, 6 times of water for the first time, 4 times of water for the second time, collecting decoction filters, and leaves standstill, and is subsequent use; Extracting solution is concentrated into 4L, extracts 50 ℃ of concentrated solutions, vacuum 0.10MPa drying under reduced pressure to moisture 4% is pulverized, and is subsequent use; The dry powder that crushes is added the 1100G dextrin mix, cross 100 mesh sieves, the ethanol system soft material with 85%, 20 mesh sieves are granulated, and 14 mesh sieve granulate promptly get granule after 60 ℃ of oven dry.
Embodiment 3
1. pharmaceutical composition consumption:
Folium Mori 30g, Fructus Lycii 15g, Fructus Momordicae charantiae 30g, Radix Astragali 15g, Herba Dendrobii 6g, RHIIZOMA DIOSCOREAE frOm Henan of China 30g, Radix Puerariae 15g, Herba Portulacae 8g
2. method for preparing
RHIIZOMA DIOSCOREAE frOm Henan of China, Herba Dendrobii are mixed pulverizing, cross 100 mesh sieves, get medicated powder, subsequent use; With the Radix Astragali, Folium Mori, Fructus Lycii, Fructus Momordicae charantiae, Radix Puerariae, the medicinal residues of Herba Portulacae and RHIIZOMA DIOSCOREAE frOm Henan of China and Herba Dendrobii mix, decocte with water 2 times, 10 times of water for the first time, 8 times of water for the second time, collecting decoction filters, and leaves standstill, and is subsequent use; Extracting solution is concentrated into 4L, extracts 50 ℃ of concentrated solutions, vacuum 0.10MPa drying under reduced pressure to moisture 3% is pulverized, and is subsequent use; The dry powder that crushes is added the 1100G dextrin mix, cross 100 mesh sieves, the ethanol system soft material with 85%, 20 mesh sieves are granulated, and 14 mesh sieve granulate promptly get granule after 60 ℃ of oven dry.
Embodiment 4
1. pharmaceutical composition consumption:
Folium Mori 10g, Fructus Lycii 15g, Fructus Momordicae charantiae 10g, Radix Astragali 5g, Herba Dendrobii 2g, RHIIZOMA DIOSCOREAE frOm Henan of China 30g, Radix Puerariae 5g, Herba Portulacae 8g
2. method for preparing
RHIIZOMA DIOSCOREAE frOm Henan of China, Herba Dendrobii are mixed pulverizing, cross 100 mesh sieves, get medicated powder, subsequent use; With the Radix Astragali, Folium Mori, Fructus Lycii, Fructus Momordicae charantiae, Radix Puerariae, the medicinal residues of Herba Portulacae and RHIIZOMA DIOSCOREAE frOm Henan of China and Herba Dendrobii mix, decocte with water 2 times, 7 times of water for the first time, 5 times of water for the second time, collecting decoction filters, and leaves standstill, and is subsequent use; Extracting solution is concentrated into 4L, extracts 50 ℃ of concentrated solutions, vacuum 0.10MPa drying under reduced pressure to moisture 2% is pulverized, and is subsequent use; The dry powder that crushes is added the 1100G dextrin mix, cross 100 mesh sieves, the ethanol system soft material with 85%, 20 mesh sieves are granulated, and 14 mesh sieve granulate promptly get granule after 60 ℃ of oven dry.
Embodiment 5
1. pharmaceutical composition consumption:
Folium Mori 30g, Fructus Lycii 5g, Fructus Momordicae charantiae 30g, Radix Astragali 5g, Herba Dendrobii 2g, RHIIZOMA DIOSCOREAE frOm Henan of China 30g, Radix Puerariae 5g, Herba Portulacae 8g
2. method for preparing
RHIIZOMA DIOSCOREAE frOm Henan of China, Herba Dendrobii are mixed pulverizing, cross 100 mesh sieves, get medicated powder, subsequent use; With the Radix Astragali, Folium Mori, Fructus Lycii, Fructus Momordicae charantiae, Radix Puerariae, the medicinal residues of Herba Portulacae and RHIIZOMA DIOSCOREAE frOm Henan of China and Herba Dendrobii mix, decocte with water 2 times, 9 times of water for the first time, 7 times of water for the second time, collecting decoction filters, and leaves standstill, and is subsequent use; Extracting solution is concentrated into 4L, extracts 50 ℃ of concentrated solutions, vacuum 0.10MPa drying under reduced pressure to moisture 1% is pulverized, and is subsequent use; The dry powder that crushes is added the 1100G dextrin mix, cross 100 mesh sieves, the ethanol system soft material with 85%, 20 mesh sieves are granulated, and 14 mesh sieve granulate promptly get granule after 60 ℃ of oven dry.
Embodiment 6
1. pharmaceutical composition consumption:
Folium Mori 12g, Fructus Lycii 9g, Fructus Momordicae charantiae 18g, Radix Astragali 10g, Herba Dendrobii 5g, RHIIZOMA DIOSCOREAE frOm Henan of China 14g, Radix Puerariae 8g, Herba Portulacae 5g
2. method for preparing
RHIIZOMA DIOSCOREAE frOm Henan of China, Herba Dendrobii are mixed pulverizing, cross 100 mesh sieves, get medicated powder, subsequent use; With the Radix Astragali, Folium Mori, Fructus Lycii, Fructus Momordicae charantiae, Radix Puerariae, the medicinal residues of Herba Portulacae and RHIIZOMA DIOSCOREAE frOm Henan of China and Herba Dendrobii mix, decocte with water 2 times, 8 times of water for the first time, 6 times of water for the second time, collecting decoction filters, and leaves standstill, and is subsequent use; Extracting solution is concentrated into 4L, extracts 50 ℃ of concentrated solutions, vacuum 0.10MPa drying under reduced pressure to moisture 1.5% is pulverized, and is subsequent use; The dry powder that crushes is added the 1100G dextrin mix, cross 100 mesh sieves, the ethanol system soft material with 85%, 20 mesh sieves are granulated, and 14 mesh sieve granulate promptly get granule after 60 ℃ of oven dry.
Embodiment 7
1. pharmaceutical composition consumption:
Folium Mori 18g, Fructus Lycii 12g, Fructus Momordicae charantiae 16g, Radix Astragali 8g, Herba Dendrobii 3g, RHIIZOMA DIOSCOREAE frOm Henan of China 17g, Radix Puerariae 10g, Herba Portulacae 7g
2. method for preparing
RHIIZOMA DIOSCOREAE frOm Henan of China, Herba Dendrobii are mixed pulverizing, cross 100 mesh sieves, get medicated powder, subsequent use; With the Radix Astragali, Folium Mori, Fructus Lycii, Fructus Momordicae charantiae, Radix Puerariae, the medicinal residues of Herba Portulacae and RHIIZOMA DIOSCOREAE frOm Henan of China and Herba Dendrobii mix, decocte with water 2 times, 9 times of water for the first time, 5 times of water for the second time, collecting decoction filters, and leaves standstill, and is subsequent use; Extracting solution is concentrated into 4L, extracts 50 ℃ of concentrated solutions, vacuum 0.10MPa drying under reduced pressure to moisture 2.5% is pulverized, and is subsequent use; The dry powder that crushes is added the 1100G dextrin mix, cross 100 mesh sieves, the ethanol system soft material with 85%, 20 mesh sieves are granulated, and 14 mesh sieve granulate promptly get granule after 60 ℃ of oven dry.
Embodiment 8
1. pharmaceutical composition consumption:
Folium Mori 25g, Fructus Lycii 6g, Fructus Momordicae charantiae 28g, Radix Astragali 11g, Herba Dendrobii 4g, RHIIZOMA DIOSCOREAE frOm Henan of China 22g, Radix Puerariae 15g, Herba Portulacae 8g
2. method for preparing
RHIIZOMA DIOSCOREAE frOm Henan of China, Herba Dendrobii are mixed pulverizing, cross 100 mesh sieves, get medicated powder, subsequent use; With the Radix Astragali, Folium Mori, Fructus Lycii, Fructus Momordicae charantiae, Radix Puerariae, the medicinal residues of Herba Portulacae and RHIIZOMA DIOSCOREAE frOm Henan of China and Herba Dendrobii mix, decocte with water 2 times, 6 times of water for the first time, 5 times of water for the second time, collecting decoction filters, and leaves standstill, and is subsequent use; Extracting solution is concentrated into 4L, extracts 50 ℃ of concentrated solutions, vacuum 0.10MPa drying under reduced pressure to moisture 4.5% is pulverized, and is subsequent use; The dry powder that crushes is added the 1100G dextrin mix, cross 100 mesh sieves, the ethanol system soft material with 85%, 20 mesh sieves are granulated, and 14 mesh sieve granulate promptly get granule after 60 ℃ of oven dry.
Claims (5)
1. pharmaceutical preparation of treating diabetes is characterized in that medicine of the present invention is made up of Folium Mori, Fructus Lycii, Fructus Momordicae charantiae, the Radix Astragali, Herba Dendrobii, RHIIZOMA DIOSCOREAE frOm Henan of China, Radix Puerariae, Herba Portulacae eight flavor Chinese medicines.
2. a kind of pharmaceutical preparation of treating diabetes as claimed in claim 1 is characterized in that each amount ranges of forming is following in the medicine: Folium Mori 10-30g, Fructus Lycii 5-15g, Fructus Momordicae charantiae 10-30g, Radix Astragali 5-15g, Herba Dendrobii 2-6g, RHIIZOMA DIOSCOREAE frOm Henan of China 10-30g, Radix Puerariae 5-15g, Herba Portulacae 2-8g.
3. a kind of pharmaceutical preparation of treating diabetes as claimed in claim 1 is characterized in that each optimum amount of forming is following in the medicine: Folium Mori 20g, Fructus Lycii 10g, Fructus Momordicae charantiae 20g, Radix Astragali 10g, Herba Dendrobii 4g, RHIIZOMA DIOSCOREAE frOm Henan of China 20g, Radix Puerariae 10g, Herba Portulacae 5g.
4. a kind of pharmaceutical preparation of treating diabetes as claimed in claim 1 is characterized in that method of making preparation comprises the steps:
RHIIZOMA DIOSCOREAE frOm Henan of China, Herba Dendrobii are mixed pulverizing, cross 100 mesh sieves, get medicated powder, subsequent use; With the Radix Astragali, Folium Mori, Fructus Lycii, Fructus Momordicae charantiae, Radix Puerariae, the medicinal residues of Herba Portulacae and RHIIZOMA DIOSCOREAE frOm Henan of China and Herba Dendrobii mix, decocte with water 2 times, 6-10 times of water for the first time, 4-8 times of water for the second time, collecting decoction filters, and leaves standstill, and is subsequent use; Extracting solution is concentrated into 4L, extracts 50 ℃ of concentrated solutions, vacuum 0.10MPa drying under reduced pressure to moisture is pulverized below 5%, and is subsequent use; The dry powder that crushes is added the 1100G dextrin mix, cross 100 mesh sieves, the ethanol system soft material with 85%, 20 mesh sieves are granulated, and 14 mesh sieve granulate promptly get granule after 60 ℃ of oven dry.
5. a kind of pharmaceutical preparation of treating diabetes as claimed in claim 1 is characterized in that said preparation is mainly used in treatment of diabetes.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100737023A CN102579839A (en) | 2012-03-20 | 2012-03-20 | Pharmaceutical preparation for treating diabetes and preparation method of same |
| CN201210309907.7A CN102784305B (en) | 2012-03-20 | 2012-08-29 | Chinese medicine composition of a kind of auxiliary hyperglycemic and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012100737023A CN102579839A (en) | 2012-03-20 | 2012-03-20 | Pharmaceutical preparation for treating diabetes and preparation method of same |
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| CN201210309907.7A Active CN102784305B (en) | 2012-03-20 | 2012-08-29 | Chinese medicine composition of a kind of auxiliary hyperglycemic and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104623380A (en) * | 2015-02-26 | 2015-05-20 | 田丰 | Drug for treating diabetes mellitus and preparation method for drug |
| CN105410623A (en) * | 2015-11-30 | 2016-03-23 | 谢晓亮 | Reinforced buckwheat instant paste and preparation method thereof |
| CN109481571A (en) * | 2018-12-19 | 2019-03-19 | 湖南希尔天然药业有限公司 | A kind of mulberry leaf preparation and preparation method thereof |
| CN110314196A (en) * | 2019-08-17 | 2019-10-11 | 哈尔滨工业大学 | A kind of preparation method of mulberry leaf compound hypoglycemic instant |
| CN110368452A (en) * | 2019-06-30 | 2019-10-25 | 杨顺平 | Dendrobium kudzu beans |
| CN113332395A (en) * | 2021-07-28 | 2021-09-03 | 吉林医药学院 | Traditional Chinese medicine composition for treating type 2 diabetes and preparation method thereof |
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| CN106722918A (en) * | 2015-11-25 | 2017-05-31 | 北京华昱安然医药科技有限公司 | A kind of hypoglycemia healthcare food and preparation method thereof |
| CN108310278A (en) * | 2018-04-01 | 2018-07-24 | 张奉明 | A kind of dendrobium candidum composition and preparation method thereof of beneficial blood glucose health |
| CN110179117A (en) * | 2019-07-15 | 2019-08-30 | 青岛瑞思德生物科技有限公司 | A kind of hypoglycemic particle electuary and preparation method thereof |
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2012
- 2012-03-20 CN CN2012100737023A patent/CN102579839A/en active Pending
- 2012-08-29 CN CN201210309907.7A patent/CN102784305B/en active Active
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104623380A (en) * | 2015-02-26 | 2015-05-20 | 田丰 | Drug for treating diabetes mellitus and preparation method for drug |
| CN104623380B (en) * | 2015-02-26 | 2019-01-01 | 田江南 | A kind of medicine and preparation method thereof for treating diabetes |
| CN105410623A (en) * | 2015-11-30 | 2016-03-23 | 谢晓亮 | Reinforced buckwheat instant paste and preparation method thereof |
| CN105410623B (en) * | 2015-11-30 | 2019-03-19 | 河北康平健康产业有限责任公司 | A kind of reinforcing buckwheat fast food paste and preparation method thereof |
| CN109481571A (en) * | 2018-12-19 | 2019-03-19 | 湖南希尔天然药业有限公司 | A kind of mulberry leaf preparation and preparation method thereof |
| CN110368452A (en) * | 2019-06-30 | 2019-10-25 | 杨顺平 | Dendrobium kudzu beans |
| CN110314196A (en) * | 2019-08-17 | 2019-10-11 | 哈尔滨工业大学 | A kind of preparation method of mulberry leaf compound hypoglycemic instant |
| CN113332395A (en) * | 2021-07-28 | 2021-09-03 | 吉林医药学院 | Traditional Chinese medicine composition for treating type 2 diabetes and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102784305A (en) | 2012-11-21 |
| CN102784305B (en) | 2015-09-30 |
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Application publication date: 20120718 |