CN104288527A - Traditional Chinese medicinal composition for treating diabetes and preparation method and application thereof - Google Patents
Traditional Chinese medicinal composition for treating diabetes and preparation method and application thereof Download PDFInfo
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Abstract
The invention relates to the field of traditional Chinese medicinal preparations, in particular to a traditional Chinese medicinal composition for treating diabetes and a preparation method and application thereof. The traditional Chinese medicinal composition comprises the following medicinal raw materials in parts by weight: 1-16 parts of Chinese yam, 1-12 parts of balsam pear, 2-16 parts of white atractylodes rhizome, 2-16 parts of rhizoma atractylodis, 1-14 parts of bullbrier, 1-12 parts of pumpkin seed, 1-12 parts of cortex lycii radicis, 1-10 parts of hawthorn, 1-16 parts of polygonum cuspidatum, 1-10 parts of stiff silkworm, 1-12 parts of rhizoma polygonati, 1-10 parts of prepared rehmannia, 1-12 parts of dendrobium, 1-13 parts of wild mint, 1-14 parts of poria cocos and 1-14 parts of rhizoma alismatis. The traditional Chinese medicinal composition is good in diabetes treating effect, high in cure rate and low in recurrence rate.
Description
Technical field
The present invention relates to field of traditional Chinese, particularly a kind of Chinese medicine composition being used for the treatment of diabetes and preparation method thereof and application.
Background technology
The metabolic disease of diabetes to be one group with hyperglycemia be feature.Hyperglycemia be then due to defect of insulin secretion or its biological agent impaired, or both have concurrently and cause.Long-standing hyperglycemia during diabetes, causes various tissue, particularly eye, kidney, heart, blood vessel, neural chronic lesion, dysfunction.Clinical signs is: polydipsia, polyuria, polyphagia and become thin, and occurs typical " three-many-one-little " symptom, be more common in type 1 diabetes during serious hyperglycemia.When generation ketosis or ketoacidosis, " three-many-one-little " symptom is more obvious; What have also presents fatigue and weak, and obesity is more common in type 2 diabetes mellitus.Type 2 diabetes mellitus premorbid often has obesity, if can not get timely diagnosis, body weight can decline gradually.
Along with the more prevalent property of diabetes, the treatment means at present for diabetes is also more and more abundanter.At present, the means of conventional treatment diabetes comprise oral drug therapy, insulinize, exercise therapy or Diet Therapy.The diagnosis and treatment of the traditional Chinese medical science to diabetes especially chronic diabetes have the opinion of its uniqueness, and have obtained good curative effect and progress.The traditional Chinese medical science is started with from the macroscopic analysis cause of disease, pathogenesis, determines the attribute of chronic diabetes.It is generally acknowledged diabetes mainly due to the ferritic deficiency of YIN, the five internal organs are weak, multiple because of eating and drinking without temperance, surfeit delicious food, disorder of emotion, and labor for excessively, and causes deficiency of kidney-YIN, lung dryness of the stomach heat; Pathogenesis emphasis is that the deficiency of YIN is scorching, and is this with the deficiency of YIN, and scorching is mark; With the passing of time disease prolongs, deficiency of YIN affecting YANG, deficiency in both YIN and YANG; The deficiency of YIN is scorching, and consumption Tianjin liquid that burns makes blood viscous, and blood is not smooth forms the stasis of blood; Deficiency of YIN affecting YANG, yang deficiency cold coagulation, also can cause sun in blood stasis.So the traditional Chinese medical science, according to pathogenesis and method for the treatment of, just can find corresponding side's medicine.Because the cause of disease of diabetes is various, pathogenesis is mixed, clinically according to the pathogenic characteristic of chronic diabetes, the key affecting its lesion growth should be caught, change the process of disease, thus reach the object of progressively curing.But on the dosage of Chinese medicine medication, should carefully consider, the compatibility relationship of concrete how much dosage and monarch needs long-term clinical practice.Thus it is a lot of intricate also to occur on the market, and the uneven prescription of effect, much exist the problem that onset is slow, specific aim is poor, still needs to improve or break through.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of effectively can treat diabetes and the little Chinese medicine composition of short treating period, side effect.
The present invention still further provides preparation method and its application of above-mentioned Chinese medicine composition.
The present invention discloses a kind of Chinese medicine composition being used for the treatment of diabetes, its crude drug consists of: Rhizoma Dioscoreae 1-16 weight portion, Fructus Momordicae charantiae 1-12 weight portion, Rhizoma Atractylodis Macrocephalae 2-16 weight portion, Rhizoma Atractylodis 2-16 weight portion, pulls out chinaroot greenbrier 1-14 weight portion, Semen Cucurbitae 1-12 weight portion, Cortex Lycii 1-12 weight portion, Fructus Crataegi 1-10 weight portion, Rhizoma Polygoni Cuspidati 1-16 weight portion, Bombyx Batryticatus 1-10 weight portion, Rhizoma Polygonati 1-12 weight portion, Radix Rehmanniae Preparata 1-10 weight portion, stone square rafter 1-12 weight portion, wild mint 1-13 weight portion, Poria 1-14 weight portion, Rhizoma Alismatis 1-14 weight portion.
Further, the described Chinese medicine composition being used for the treatment of diabetes, its crude drug consists of: Rhizoma Dioscoreae 8-12 weight portion, Fructus Momordicae charantiae 3-8 weight portion, Rhizoma Atractylodis Macrocephalae 8-15 weight portion, Rhizoma Atractylodis 4-12 weight portion, pull out chinaroot greenbrier 3-10 weight portion, Semen Cucurbitae 3-8 weight portion, Cortex Lycii 3-10 weight portion, Fructus Crataegi 2-6 weight portion, Rhizoma Polygoni Cuspidati 3-12 weight portion, Bombyx Batryticatus 2-6 weight portion, Rhizoma Polygonati 2-8 weight portion, Radix Rehmanniae Preparata 2-8 weight portion, stone square rafter 2-7 weight portion, wild mint 2-9 weight portion, Poria 4-10 weight portion, Rhizoma Alismatis 3-10 weight portion.
Preferably, the described Chinese medicine composition being used for the treatment of diabetes, its crude drug consists of: Rhizoma Dioscoreae 10 weight portion, Fructus Momordicae charantiae 6 weight portion, the Rhizoma Atractylodis Macrocephalae 12 weight portion, Rhizoma Atractylodis 8 weight portion, pull out chinaroot greenbrier 8 weight portion, Semen Cucurbitae 6 weight portion, Cortex Lycii 7 weight portion, Fructus Crataegi 5 weight portion, Rhizoma Polygoni Cuspidati 8 weight portion, Bombyx Batryticatus 4 weight portion, Rhizoma Polygonati 6 weight portion, Radix Rehmanniae Preparata 5 weight portion, stone square rafter 4 weight portion, wild mint 6 weight portion, Poria 8 weight portion, Rhizoma Alismatis 7 weight portion.
The invention also discloses and add customary adjuvant by arbitrary described Chinese medicine composition selectivity being used for the treatment of diabetes, conveniently the acceptable clinically preparation made of technique.
Further described preparation, comprises electuary, powder, tablet, granule, capsule, mixture, pill, injection or drop pill.
The invention also discloses a kind of method preparing arbitrary described Chinese medicine composition: get Rhizoma Dioscoreae, Fructus Momordicae charantiae, the Rhizoma Atractylodis Macrocephalae according to selected weight portion, Rhizoma Atractylodis, pull out chinaroot greenbrier, Semen Cucurbitae, Cortex Lycii, Fructus Crataegi, Rhizoma Polygoni Cuspidati, Bombyx Batryticatus, Rhizoma Polygonati, Radix Rehmanniae Preparata, stone square rafter, wild mint, Poria and Rhizoma Alismatis, selectivity adds customary adjuvant, conveniently technique, makes acceptable preparation clinically.
Further, described preparation method, comprises the steps:
According to selected parts by weight Rhizoma Dioscoreae, Fructus Momordicae charantiae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, pull out chinaroot greenbrier, Semen Cucurbitae, Cortex Lycii, Fructus Crataegi, Rhizoma Polygoni Cuspidati, Bombyx Batryticatus, Rhizoma Polygonati, Radix Rehmanniae Preparata, stone square rafter, wild mint, Poria and Rhizoma Alismatis, remix after pulverizing or pulverizing respectively, sieve after mixing, and selectivity adds customary adjuvant, conveniently technique, makes acceptable preparation clinically.
More excellent, described preparation method, comprises the steps:
Get Rhizoma Dioscoreae, Fructus Momordicae charantiae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis according to selected parts by weight, pull out chinaroot greenbrier, Semen Cucurbitae, Cortex Lycii, Fructus Crataegi, Rhizoma Polygoni Cuspidati, Bombyx Batryticatus, Rhizoma Polygonati, Radix Rehmanniae Preparata, stone square rafter, wild mint, Poria and Rhizoma Alismatis, mixing, extracting in water, filters and collects filtrate, obtaining concentrated solution after concentrating under reduced pressure; Above-mentioned concentrated solution selectivity is added customary adjuvant, conveniently technique, make clinical acceptable preparation; Or
Get Rhizoma Dioscoreae, Fructus Momordicae charantiae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis according to selected parts by weight, pull out chinaroot greenbrier, Semen Cucurbitae, Cortex Lycii, Fructus Crataegi, Rhizoma Polygoni Cuspidati, Bombyx Batryticatus, Rhizoma Polygonati, Radix Rehmanniae Preparata, stone square rafter, wild mint, Poria and Rhizoma Alismatis, mixing, adds ethanol extraction, filters and collect filtrate, obtaining concentrated solution after concentrating under reduced pressure; Above-mentioned concentrated solution selectivity is added customary adjuvant, conveniently technique, make clinical acceptable preparation.
Preferred further, described preparation method, comprises the steps:
(1) get wherein one or more raw material components mixing according to selected parts by weight, add alcohol reflux, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) again according to raw material components mixing under selected parts by weight remainder, direct extracting in water, or mix extracting in water again with the medicinal residues after alcohol extraction in step (1), filter and collect filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) above-mentioned concentrated solution selectivity is added customary adjuvant, conveniently technique, make clinical acceptable preparation.
The invention also discloses Chinese medicine composition that arbitrary described Chinese medicine composition or arbitrary described method prepare for the preparation of the purposes in treatment diabetes medicament.
In Chinese medicine composition of the present invention; Rhizoma Dioscoreae: sweet in the mouth; property flat, nontoxic; return spleen, lung, kidney channel; principle active component dioscin is a kind of polysaccharide; there is protective effect to the rat Langerhans islet B cell damage caused by alloxan, have hypoglycemic activity to fasting rat and rabbit, the hyperglycemia that alloxan etc. causes can be controlled.Fructus Momordicae charantiae: abnormal smells from the patient is bitter, nontoxic, cold in nature, enter the heart, liver, spleen, lung meridian, have clearing summer heat, improving eyesight removing toxic substances, reducing pressure and sugar, diuresis removing heat from blood, separate that labor clears away heart-fire, effect of QI invigorating tonifying YANG, find according to the study, it also has good blood sugar lowering, antiviral and anti-cancer efficacy.The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet; warm in nature; return spleen, stomach warp, invigorating the spleen and benefiting QI, dampness diuretic; there is obvious and lasting diuresis; rabbit gavage decoct or extractum, blood glucose is in a slight decrease, and rat oral gavage decoct has the assimilation of glucose in acceleration bodies thus to reduce blood glucose; mice takes decoct orally the liver protecting, the liver glycogen minimizing effect preventing carbon tetrachloride from causing.Rhizoma Atractylodis: acrid in the mouth, hardship, warm in nature, return spleen, stomach, Liver Channel, have hypoglycemic activity to alloxan diabetes, the Hyperglycemia In Stz-induced Diabetic Rats level that Rhizoma Atractylodis water extract gavage can make chain phleomycin bring out reduces.Pull out chinaroot greenbrier: sweet in the mouth, acid, property is put down, and returns Liver Channel, kidney channel, expelling wind and removing dampness; Removing toxicity for eliminating carbuncles, has diaphoresis, wind dispelling, diuresis and control gonorrhea, cancer, the function of diabetes.Semen Cucurbitae: property is put down, sweet in the mouth, decoction after frying, can manage property back of the body operating point edema, diabetes.Cortex Lycii: cold in nature, sweet in the mouth, returns liver, kidney, lung meridian, mainly has the effects such as blood sugar lowering, antimicrobial, antipyretic, blood pressure lowering, blood fat reducing, immunomodulating.Fructus Crataegi: acid is sweet, and tepor, enters spleen, stomach, Liver Channel, promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis, for meat stagnation, stomach alkane distension, hyperlipidemia, also can prevent and treat diabetes cardiovascular and cerebrovascular complication.Rhizoma Polygoni Cuspidati: micro-hardship, is slightly cold, returns liver, gallbladder, lung meridian, can dispel the wind, dampness removing, can reduce incidence rate and the mortality rate of experimental animal models diabetes.Bombyx Batryticatus: there is expelling wind to relieve convulsion, effect of dissipating phlegm and resolving masses, clinical being used for controls tangible enclosed mass, as tuberosity, pharyngeal swelling pain, scrofula, wind skin ulcer urticaria etc.All get the energy that it is logical loose.Bombyx Batryticatus alcohol water-leach liquor all has hypnosis, anticonvulsant action to mice, rabbit; Its extracting solution in vivo, all have stronger anticoagulation outward; Bombyx Batryticatus powder has good hypoglycemic activity.Rhizoma Polygonati: sweet in the mouth, property is put down, and returns spleen, lung, kidney channel, and research finds that the polysaccharide in Rhizoma Polygonati has very strong inhibitory action to a-glucosidase, thus has hypoglycemic effect.Radix Rehmanniae Preparata: sweet in the mouth, tepor, returns liver, kidney channel, yin nourishing of enriching blood, life essence-filling, marrow-benefitting, and Radix Rehmanniae Preparata decoct treatment hypertension, blood pressure, serum cholesterol and triglyceride all have decline, and rheoencephalogram and electrocardiogram also make moderate progress.Stone square rafter: property slightly sweet flavor, micro-salty, cold, returns stomach, kidney, lung meridian, reinforcing stomach reg fluid, nourishing YIN and clearing away heat, and though research show its to Isolated Toad Heart then concentration level be suppression, without obvious effect during Bufo siccus lower limb vascular perfusion.Dendrobine has raise blood sugar, reduces blood pressure, weakens cardiac contractile force.Wild mint: Xin Wen, gas is fragrant, can inducing diaphoresis to dispel wind, the wind and heat dispersing effect of menthol, menthone in Herba Menthae, and brew up have refrigerant sense, be clearing away heat and promoting diuresis, and also have certain curative effect to hyperlipidemia, hypertension, arteriosclerosis, diabetes etc.Poria: sweet in the mouth, light, property is put down, and GUIXIN, spleen, kidney channel, have diuresis, immunomodulating, and hepatoprotective strengthening the spleen and stomach antitumor toxin expelling is antibacterial, promotes hemopoietic function, calmly waits effect, can be used for anhydrating swollen, insufficiency of the spleen diarrhoea, tranquilizing soporific.Rhizoma Alismatis: nature and flavor are sweet, cold, enter kidney, urinary bladder channel, diuretic, eliminating dampness by diuresis, expel the heat-evil, control dysuria, edema distension, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.
Pharmaceutical composition of the present invention with Rhizoma Dioscoreae, Fructus Momordicae charantiae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, pull out chinaroot greenbrier, Semen Cucurbitae, Cortex Lycii, Fructus Crataegi, Rhizoma Polygoni Cuspidati, Bombyx Batryticatus, Rhizoma Polygonati, Radix Rehmanniae Preparata, stone square rafter, wild mint, Poria and Rhizoma Alismatis are used as medicine, and effect of its invigorating the spleen and benefiting QI of row, heat-clearing and toxic substances removing, effectively can play and fall hypoglycemic effect, by the effective cooperation between monarch, have good curative effect to treatment diabetes, clinical cure rate is up to 98%.
Detailed description of the invention
Embodiment 1
The crude drug being used for the treatment of the Chinese medicine composition of diabetes of the present embodiment consists of: Rhizoma Dioscoreae 10 weight portion, Fructus Momordicae charantiae 6 weight portion, the Rhizoma Atractylodis Macrocephalae 12 weight portion, Rhizoma Atractylodis 8 weight portion, pulls out chinaroot greenbrier 8 weight portion, Semen Cucurbitae 6 weight portion, Cortex Lycii 7 weight portion, Fructus Crataegi 5 weight portion, Rhizoma Polygoni Cuspidati 8 weight portion, Bombyx Batryticatus 4 weight portion, Rhizoma Polygonati 6 weight portion, Radix Rehmanniae Preparata 5 weight portion, stone square rafter 4 weight portion, wild mint 6 weight portion, Poria 8 weight portion, Rhizoma Alismatis 7 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make pill.Specifically comprise:
Rhizoma Dioscoreae is got, Fructus Momordicae charantiae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis according to selected parts by weight, pull out chinaroot greenbrier, Semen Cucurbitae, Cortex Lycii, Fructus Crataegi, Rhizoma Polygoni Cuspidati, Bombyx Batryticatus, Rhizoma Polygonati, Radix Rehmanniae Preparata, stone square rafter, wild mint, Poria and Rhizoma Alismatis, pulverize respectively, cross 100 mesh sieves, mixing, adds appropriate water according to every 100g powder refined honey 20 ~ 50g, pill, dry, make water-honeyed pill; Or add refined honey 80 ~ 110g and make small honey pill or big honeyed pills, to obtain final product.
Embodiment 2
The crude drug being used for the treatment of the Chinese medicine composition of diabetes of the present embodiment consists of: Rhizoma Dioscoreae 1 weight portion, Fructus Momordicae charantiae 1 weight portion, the Rhizoma Atractylodis Macrocephalae 2 weight portion, Rhizoma Atractylodis 2 weight portion, pulls out chinaroot greenbrier 1 weight portion, Semen Cucurbitae 1 weight portion, Cortex Lycii 1 weight portion, Fructus Crataegi 1 weight portion, Rhizoma Polygoni Cuspidati 1 weight portion, Bombyx Batryticatus 1 weight portion, Rhizoma Polygonati 1 weight portion, Radix Rehmanniae Preparata 1 weight portion, stone square rafter 1 weight portion, wild mint 1 weight portion, Poria 1 weight portion, Rhizoma Alismatis 1 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make tablet.Specifically comprise:
(1) Rhizoma Dioscoreae is got, Fructus Momordicae charantiae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis according to selected parts by weight, pull out chinaroot greenbrier, Semen Cucurbitae, Cortex Lycii, Fructus Crataegi, Rhizoma Polygoni Cuspidati, Bombyx Batryticatus, Rhizoma Polygonati, Radix Rehmanniae Preparata, stone square rafter, wild mint, Poria and Rhizoma Alismatis, mixing, by the water reflux, extract, of 10 volume times amount, reflux, extract, 2 times under maintenance temperature 60 C, each 3h, filters and collects filtrate, obtaining aqueous extract;
(2) aqueous extract obtained in step (1) being evaporated to relative density is 1.05-1.30 (40 ~ 60 DEG C), obtains concentrated solution;
(3) by above-mentioned concentrated solution vacuum drying, pulverize, sieve, obtain dry extract, add customary adjuvant, conveniently technique, make tablet.
Embodiment 3
The crude drug being used for the treatment of the Chinese medicine composition of diabetes of the present embodiment consists of: Rhizoma Dioscoreae 8 weight portion, Fructus Momordicae charantiae 3 weight portion, the Rhizoma Atractylodis Macrocephalae 8 weight portion, Rhizoma Atractylodis 4 weight portion, pulls out chinaroot greenbrier 3 weight portion, Semen Cucurbitae 3 weight portion, Cortex Lycii 3 weight portion, Fructus Crataegi 2 weight portion, Rhizoma Polygoni Cuspidati 3 weight portion, Bombyx Batryticatus 2 weight portion, Rhizoma Polygonati 2 weight portion, Radix Rehmanniae Preparata 2 weight portion, stone square rafter 2 weight portion, wild mint 2 weight portion, Poria 4 weight portion, Rhizoma Alismatis 3 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make powder.Specifically comprise:
(1) Rhizoma Dioscoreae is got, Fructus Momordicae charantiae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis according to selected parts by weight, pull out chinaroot greenbrier, Semen Cucurbitae, Cortex Lycii, Fructus Crataegi, Rhizoma Polygoni Cuspidati, Bombyx Batryticatus, Rhizoma Polygonati, Radix Rehmanniae Preparata, stone square rafter, wild mint, Poria and Rhizoma Alismatis, mixing, with 75% alcohol reflux of 8 volume times amount, reflux, extract, 3 times at maintenance temperature 80 DEG C, each 1.5h, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) the alcohol extract concentrating under reduced pressure will obtained in step (1), obtains concentrated solution;
(3) be 1.05-1.30 (40 ~ 60 DEG C) by above-mentioned concentrated solution vacuum drying relative density, pulverize, sieve, obtain dry extract, add customary adjuvant, conveniently technique, make powder.
Embodiment 4
The crude drug being used for the treatment of the Chinese medicine composition of diabetes of the present embodiment consists of: Rhizoma Dioscoreae 12 weight portion, Fructus Momordicae charantiae 8 weight portion, the Rhizoma Atractylodis Macrocephalae 15 weight portion, Rhizoma Atractylodis 12 weight portion, pulls out chinaroot greenbrier 10 weight portion, Semen Cucurbitae 8 weight portion, Cortex Lycii 10 weight portion, Fructus Crataegi 6 weight portion, Rhizoma Polygoni Cuspidati 12 weight portion, Bombyx Batryticatus 6 weight portion, Rhizoma Polygonati 8 weight portion, Radix Rehmanniae Preparata 8 weight portion, stone square rafter 7 weight portion, wild mint 9 weight portion, Poria 10 weight portion, Rhizoma Alismatis 10 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make granule.Specifically comprise:
(1) Rhizoma Dioscoreae is got, Fructus Momordicae charantiae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis according to selected parts by weight, pull out chinaroot greenbrier, Semen Cucurbitae, Cortex Lycii, Fructus Crataegi, Rhizoma Polygoni Cuspidati, Bombyx Batryticatus, Rhizoma Polygonati, Radix Rehmanniae Preparata, stone square rafter, wild mint, Poria and Rhizoma Alismatis, mixing, with 90% alcohol reflux of 4 volume times amount, reflux, extract, 3 times under maintenance temperature 70 C, each 1.5h, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) in the medicinal residues after the alcohol extraction in step (1), add the water extraction 2 times of 15 volume times amount again, each 2h, filters and collects filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, 60 DEG C of concentrating under reduced pressure, obtain concentrated solution;
(4) fluidized bed granulation is carried out with the concentrated solution obtained in step (3), be that the dextrin of 30 ~ 75% is for fluidisation carrier to account for described concentrated solution mass ratio, with account for described concentrated solution mass ratio be 1 ~ 5% traditional binders granulate, control that its feed liquor flow velocity is 2.5ml/min, fluidized pressure is 0.2 ~ 0.5bar, atomizing pressure is 1.0 ~ 1.8bar, temperature 55 DEG C, granulate, and increase gradually along with particle in fluid bed, adjustment fluidized pressure and atomizing pressure, keep the fluidized state of material good, temperature of charge remains between 35 ~ 37 DEG C.After feed liquor terminates, continue fluidized drying 1 hour, obtain granule.
Embodiment 5
The crude drug being used for the treatment of the Chinese medicine composition of diabetes of the present embodiment consists of: Rhizoma Dioscoreae 16 weight portion, Fructus Momordicae charantiae 12 weight portion, the Rhizoma Atractylodis Macrocephalae 16 weight portion, Rhizoma Atractylodis 16 weight portion, pulls out chinaroot greenbrier 14 weight portion, Semen Cucurbitae 12 weight portion, Cortex Lycii 12 weight portion, Fructus Crataegi 10 weight portion, Rhizoma Polygoni Cuspidati 16 weight portion, Bombyx Batryticatus 10 weight portion, Rhizoma Polygonati 12 weight portion, Radix Rehmanniae Preparata 10 weight portion, stone square rafter 12 weight portion, wild mint 13 weight portion, Poria 14 weight portion, Rhizoma Alismatis 14 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make capsule.Specifically comprise:
(1) get it filled according to selected parts by weight, Fructus Momordicae charantiae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, pull out chinaroot greenbrier, Semen Cucurbitae, Cortex Lycii, Fructus Crataegi, Rhizoma Polygoni Cuspidati, Bombyx Batryticatus, Rhizoma Polygonati, Radix Rehmanniae Preparata, stone square rafter, wild mint, Poria and Rhizoma Alismatis, mixing, with 50% alcohol reflux of 6 volume times amount, reflux, extract, 3 times at maintenance temperature 80 DEG C, each 2h, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) in the medicinal residues after the alcohol extraction in step (1), add the water extraction 1 time of 10 volume times amount again, 2h, filters and collects filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) by above-mentioned concentrated solution vacuum drying, pulverize, sieve, obtain dry extract, directly encapsulated or encapsulated after adding customary adjuvant mix homogeneously, to obtain final product.
Embodiment 6
The crude drug being used for the treatment of the Chinese medicine composition of diabetes of the present embodiment consists of: Rhizoma Dioscoreae 1 weight portion, Fructus Momordicae charantiae 12 weight portion, the Rhizoma Atractylodis Macrocephalae 2 weight portion, Rhizoma Atractylodis 16 weight portion, pulls out chinaroot greenbrier 1 weight portion, Semen Cucurbitae 12 weight portion, Cortex Lycii 1 weight portion, Fructus Crataegi 10 weight portion, Rhizoma Polygoni Cuspidati 1 weight portion, Bombyx Batryticatus 10 weight portion, Rhizoma Polygonati 1 weight portion, Radix Rehmanniae Preparata 10 weight portion, stone square rafter 1 weight portion, wild mint 13 weight portion, Poria 1 weight portion, Rhizoma Alismatis 14 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make mixture.Specifically comprise:
(1) Rhizoma Dioscoreae is got, Fructus Momordicae charantiae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis according to selected parts by weight, pull out chinaroot greenbrier, Semen Cucurbitae, Cortex Lycii, Fructus Crataegi, Rhizoma Polygoni Cuspidati, Bombyx Batryticatus, Rhizoma Polygonati, Radix Rehmanniae Preparata, stone square rafter, wild mint, Poria and Rhizoma Alismatis, mixing, with 70% alcohol reflux of 12 volume times amount, reflux, extract, 3 times under maintenance temperature 70 C, each 1.5h, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) in the medicinal residues after the alcohol extraction in step (1), add the water extraction 2 times of 10 volume times amount again, each 2h, filters and collects filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) by above-mentioned concentrated solution cold preservation 24 hours, filter, filtrate is boiled, and it is appropriate to add customary adjuvant, makes dissolving, filters, let cool, add water to 1000ml, stir evenly, embedding, sterilizing, namely obtains required mixture.
Embodiment 7
The crude drug being used for the treatment of the Chinese medicine composition of diabetes of the present embodiment consists of: Rhizoma Dioscoreae 7 weight portion, Fructus Momordicae charantiae 10 weight portion, the Rhizoma Atractylodis Macrocephalae 14 weight portion, Rhizoma Atractylodis 10 weight portion, pulls out chinaroot greenbrier 6 weight portion, Semen Cucurbitae 9 weight portion, Cortex Lycii 5 weight portion, Fructus Crataegi 8 weight portion, Rhizoma Polygoni Cuspidati 14 weight portion, Bombyx Batryticatus 4 weight portion, Rhizoma Polygonati 10 weight portion, Radix Rehmanniae Preparata 6 weight portion, stone square rafter 9 weight portion, wild mint 11 weight portion, Poria 12 weight portion, Rhizoma Alismatis 8 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make drop pill.Specifically comprise:
(1) Rhizoma Dioscoreae is got, Fructus Momordicae charantiae, the Rhizoma Atractylodis Macrocephalae according to selected parts by weight, Rhizoma Atractylodis, pull out chinaroot greenbrier, Semen Cucurbitae, Poria and Rhizoma Alismatis, mixing, with 90% alcohol reflux of 10 volume times amount, reflux, extract, 3 times at maintenance temperature 78 DEG C, each 4h, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) Cortex Lycii is got, Fructus Crataegi, Rhizoma Polygoni Cuspidati, Bombyx Batryticatus, Rhizoma Polygonati according to selected parts by weight, Radix Rehmanniae Preparata, stone square rafter, wild mint, mixing, by the water reflux, extract, of 7 volume times amount, reflux, extract, 2 times under maintenance temperature 60 C, each 1h, filters and collects filtrate, obtaining aqueous extract; (please applicant confirm according to above-mentioned steps crude drug order of addition successively whether can)
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) above-mentioned concentrated solution is added customary adjuvant, conveniently technique, make drop pill.
Embodiment 8
The crude drug being used for the treatment of the Chinese medicine composition of diabetes of the present embodiment consists of: Rhizoma Dioscoreae 8 weight portion, Fructus Momordicae charantiae 8 weight portion, the Rhizoma Atractylodis Macrocephalae 8 weight portion, Rhizoma Atractylodis 12 weight portion, pulls out chinaroot greenbrier 3 weight portion, Semen Cucurbitae 8 weight portion, Cortex Lycii 3 weight portion, Fructus Crataegi 6 weight portion, Rhizoma Polygoni Cuspidati 3 weight portion, Bombyx Batryticatus 6 weight portion, Rhizoma Polygonati 2 weight portion, Radix Rehmanniae Preparata 8 weight portion, stone square rafter 2 weight portion, wild mint 9 weight portion, Poria 4 weight portion, Rhizoma Alismatis 10 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make injection.Specifically comprise:
(1) Rhizoma Dioscoreae is got, Fructus Momordicae charantiae, the Rhizoma Atractylodis Macrocephalae according to selected parts by weight, Rhizoma Atractylodis, pull out chinaroot greenbrier, Semen Cucurbitae, Poria and Rhizoma Alismatis, mixing, with 70% alcohol reflux of 12 volume times amount, reflux, extract, 3 times under maintenance temperature 70 C, each 1.5h, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) Cortex Lycii is got, Fructus Crataegi, Rhizoma Polygoni Cuspidati, Bombyx Batryticatus, Rhizoma Polygonati according to selected parts by weight, Radix Rehmanniae Preparata, stone square rafter, wild mint, mixing, by the water reflux, extract, of 10 volume times amount, reflux, extract, 2 times under maintenance temperature 60 C, each 3h, filters and collects filtrate, obtaining aqueous extract; (please applicant confirm according to above-mentioned steps crude drug order of addition successively whether can)
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) filtered by above-mentioned concentrated solution, dilution, adjust ph, adds customary adjuvant, conveniently technique, makes injection.
Embodiment 9
The crude drug being used for the treatment of the Chinese medicine composition of diabetes of the present embodiment consists of: Rhizoma Dioscoreae 16 weight portion, Fructus Momordicae charantiae 1 weight portion, the Rhizoma Atractylodis Macrocephalae 16 weight portion, Rhizoma Atractylodis 2 weight portion, pulls out chinaroot greenbrier 14 weight portion, Semen Cucurbitae 1 weight portion, Cortex Lycii 12 weight portion, Fructus Crataegi 1 weight portion, Rhizoma Polygoni Cuspidati 16 weight portion, Bombyx Batryticatus 1 weight portion, Rhizoma Polygonati 12 weight portion, Radix Rehmanniae Preparata 1 weight portion, stone square rafter 12 weight portion, wild mint 1 weight portion, Poria 14 weight portion, Rhizoma Alismatis 1 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make powder.Specifically comprise:
(1) Rhizoma Dioscoreae is got, Fructus Momordicae charantiae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis according to selected parts by weight, pull out chinaroot greenbrier, Semen Cucurbitae, Cortex Lycii, Fructus Crataegi, Rhizoma Polygoni Cuspidati, Bombyx Batryticatus, Rhizoma Polygonati, Radix Rehmanniae Preparata, stone square rafter, wild mint, Poria and Rhizoma Alismatis, mixing, with 78% alcohol reflux of 12 volume times amount, reflux, extract, 3 times at maintenance temperature 85 DEG C, each 6h, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) in the medicinal residues after the alcohol extraction in step (1), add the water extraction 2 times of 9 volume times amount again, each 3h, filters and collects filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) above-mentioned concentrated solution is added customary adjuvant, conveniently technique, make powder.
Embodiment 10
The crude drug being used for the treatment of the Chinese medicine composition of diabetes of the present embodiment consists of: Rhizoma Dioscoreae 12 weight portion, Fructus Momordicae charantiae 3 weight portion, the Rhizoma Atractylodis Macrocephalae 15 weight portion, Rhizoma Atractylodis 4 weight portion, pulls out chinaroot greenbrier 10 weight portion, Semen Cucurbitae 3 weight portion, Cortex Lycii 10 weight portion, Fructus Crataegi 2 weight portion, Rhizoma Polygoni Cuspidati 12 weight portion, Bombyx Batryticatus 2 weight portion, Rhizoma Polygonati 8 weight portion, Radix Rehmanniae Preparata 2 weight portion, stone square rafter 7 weight portion, wild mint 2 weight portion, Poria 10 weight portion, Rhizoma Alismatis 3 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make electuary.Specifically comprise:
(1) Rhizoma Dioscoreae is got, Fructus Momordicae charantiae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis according to selected parts by weight, pull out chinaroot greenbrier, Semen Cucurbitae, Cortex Lycii, Fructus Crataegi, Rhizoma Polygoni Cuspidati, Bombyx Batryticatus, Rhizoma Polygonati, Radix Rehmanniae Preparata, stone square rafter, wild mint, Poria and Rhizoma Alismatis, mixing, with 70% alcohol reflux of 10 volume times amount, reflux, extract, 2 times at maintenance temperature 85 DEG C, each 2h, filter and collect filtrate, less than 60 DEG C decompression recycling ethanols, to without alcohol taste, obtain alcohol extract;
(2) in the medicinal residues after the alcohol extraction in step (1), add the water extraction 3 times of 10 volume times amount again, each 1.5h, filters and collects filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) above-mentioned concentrated solution is added customary adjuvant, conveniently technique, make electuary.
Clinical experiment example
Getting the preparation prepared in embodiments of the invention 1 is the elaboration that example carries out effect, clinical take for honeyed pill, oral, every day 2 times, each serving with 8 ~ 10g, 300 routine diabetes conditions patients are treated, take 40-70 days continuously.Cure 294 examples, clinical effective 300 examples, invalid 0 example, overall cure rate reaches 98%.Follow-up Continuous Tracking follows up a case by regular visits to December, without recurrence.
Model case
Case 1
Zhang Shuimo, Nanchang, 60 years old, man.Ill blood glucose 11-13mmol/L more than 7 years, seek medical advice always take traditional Chinese medicine, Western medicine all do not take a turn for the better.Foretaste this Chinese medicine composition 10 days, have about seven days blood glucose and fall 9-10.5mmol/L, then eat 20 pairs, blood glucose falls 5.2-5.9mmol/L.Call-on back by phone after spending 1 year, health each side index is fine, until now, fully recovered 7 years and all do not recurred.
Case 2
Yang Qingchao, Shangrao, Jiangxi, 42 years old, man.Suffer from diabetes and have blood glucose 10-12mmol/L more than 3 years, seek medical advice always take traditional Chinese medicine, Western medicine has no improvement.Foretaste this Chinese medicine composition 10 days, have about seven days blood glucose and fall 9-11mmol/L, then adhere to eating 30 days, blood glucose falls 5.4-6.0mmol/L.Call-on back by phone after spending 1 year, health each side index is fine, until now, fully recovered 7 years and all do not recurred.
Case 3
Zhu Qiyun, Liu Shi resemble sun, 48 years old, man.Suffer from diabetes and have blood glucose 9-11mmol/L more than 4 years, seek medical advice always take traditional Chinese medicine, Western medicine has no improvement.Foretaste this Chinese medicine composition 10 days, have about seven days blood glucose and fall 8-10mmol/L, then adhere to eating 30 days, blood glucose falls 5.4-9.2mmol/L.Call-on back by phone after spending 1 year, health each side index is fine, until now, fully recovered 7 years and all do not recurred.
Case 4
Chen Jianzhu, Yueqing City father-in-law's Yang, 53 years old, man.Suffer from diabetes and have blood glucose 8.7-11mmol/L more than 5 years, take traditional Chinese medicine always, Western medicine has no improvement.Foretaste this Chinese medicine composition 10 days, have about seven days blood glucose and fall 7.6-9.5mmol/L, then adhere to eating 30 days, blood glucose falls 5.4-6.0mmol/L.Call-on back by phone after spending 1 year, health each side index is fine, until now, fully recovered 7 years and all do not recurred.
Case 5
Open elegant son-in-law, Yuyao City, 56 years old, female.Suffer from diabetes and have blood glucose 13-17mmol/L more than 3 years, eyes do not see, and both feet have edema phenomenon, have broken and have been difficult to.Take traditional Chinese medicine always, Western medicine has no improvement.Foretaste this Chinese medicine composition 15 secondary, have and within about 10 days, do not feel to take a turn for the better, so drug withdrawal 10 days, eat 5 pairs again, blood glucose falls 12-15mmol/L, open 15 pairs again, decline 10-12mmol/L, open again 15 pairs, eat rear blood glucose and raise 13-16mmol/L, medicine stops seven days, and blood glucose drops to 11-13mmol/L, opens again 15 secondary blood glucose and is lowered to 8-10mmol/L, open 30 pairs again, blood glucose drops to 5.4-60mmol/L.Call-on back by phone after spending 1 year, health each side index is fine, until now, fully recovered 7 years and all do not recurred.
Be more than concrete case, when proving that Chinese medicine composition of the present invention is used for the treatment of diabetes by the multinomial case of reality, good effect, cure rate are up to 98%, and relapse rate is low.It should be noted that, Chinese medicine composition of the present invention all has good therapeutic effect for the diabetes of each degree, and cure rate is higher.
Obviously, above-described embodiment is only for clearly example being described, and the restriction not to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here exhaustive without the need to also giving all embodiments.And thus the apparent change of extending out or variation be still among the protection domain of the invention.
Claims (10)
1. one kind is used for the treatment of the Chinese medicine composition of diabetes, it is characterized in that, the crude drug of said composition consists of: Rhizoma Dioscoreae 1-16 weight portion, Fructus Momordicae charantiae 1-12 weight portion, Rhizoma Atractylodis Macrocephalae 2-16 weight portion, Rhizoma Atractylodis 2-16 weight portion, pull out chinaroot greenbrier 1-14 weight portion, Semen Cucurbitae 1-12 weight portion, Cortex Lycii 1-12 weight portion, Fructus Crataegi 1-10 weight portion, Rhizoma Polygoni Cuspidati 1-16 weight portion, Bombyx Batryticatus 1-10 weight portion, Rhizoma Polygonati 1-12 weight portion, Radix Rehmanniae Preparata 1-10 weight portion, stone square rafter 1-12 weight portion, wild mint 1-13 weight portion, Poria 1-14 weight portion, Rhizoma Alismatis 1-14 weight portion.
2. be used for the treatment of the Chinese medicine composition of diabetes as claimed in claim 1, it is characterized in that, the crude drug of said composition consists of: Rhizoma Dioscoreae 8-12 weight portion, Fructus Momordicae charantiae 3-8 weight portion, Rhizoma Atractylodis Macrocephalae 8-15 weight portion, Rhizoma Atractylodis 4-12 weight portion, pull out chinaroot greenbrier 3-10 weight portion, Semen Cucurbitae 3-8 weight portion, Cortex Lycii 3-10 weight portion, Fructus Crataegi 2-6 weight portion, Rhizoma Polygoni Cuspidati 3-12 weight portion, Bombyx Batryticatus 2-6 weight portion, Rhizoma Polygonati 2-8 weight portion, Radix Rehmanniae Preparata 2-8 weight portion, stone square rafter 2-7 weight portion, wild mint 2-9 weight portion, Poria 4-10 weight portion, Rhizoma Alismatis 3-10 weight portion.
3. be used for the treatment of the Chinese medicine composition of diabetes as claimed in claim 1 or 2, it is characterized in that, the crude drug of said composition consists of: Rhizoma Dioscoreae 10 weight portion, Fructus Momordicae charantiae 6 weight portion, the Rhizoma Atractylodis Macrocephalae 12 weight portion, Rhizoma Atractylodis 8 weight portion, pull out chinaroot greenbrier 8 weight portion, Semen Cucurbitae 6 weight portion, Cortex Lycii 7 weight portion, Fructus Crataegi 5 weight portion, Rhizoma Polygoni Cuspidati 8 weight portion, Bombyx Batryticatus 4 weight portion, Rhizoma Polygonati 6 weight portion, Radix Rehmanniae Preparata 5 weight portion, stone square rafter 4 weight portion, wild mint 6 weight portion, Poria 8 weight portion, Rhizoma Alismatis 7 weight portion.
4. add customary adjuvant by the arbitrary described Chinese medicine composition selectivity being used for the treatment of diabetes of claim 1-3, conveniently the acceptable clinically preparation made of technique.
5. preparation as claimed in claim 4, is characterized in that, comprise electuary, powder, tablet, granule, capsule, mixture, pill, injection or drop pill.
6. prepare a method for the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that: get Rhizoma Dioscoreae, Fructus Momordicae charantiae, the Rhizoma Atractylodis Macrocephalae according to selected weight portion, Rhizoma Atractylodis, pull out chinaroot greenbrier, Semen Cucurbitae, Cortex Lycii, Fructus Crataegi, Rhizoma Polygoni Cuspidati, Bombyx Batryticatus, Rhizoma Polygonati, Radix Rehmanniae Preparata, stone square rafter, wild mint, Poria and Rhizoma Alismatis, selectivity adds customary adjuvant, conveniently technique, makes acceptable preparation clinically.
7. preparation method as claimed in claim 6, is characterized in that, comprise the steps:
According to selected parts by weight Rhizoma Dioscoreae, Fructus Momordicae charantiae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, pull out chinaroot greenbrier, Semen Cucurbitae, Cortex Lycii, Fructus Crataegi, Rhizoma Polygoni Cuspidati, Bombyx Batryticatus, Rhizoma Polygonati, Radix Rehmanniae Preparata, stone square rafter, wild mint, Poria and Rhizoma Alismatis, remix after pulverizing or pulverizing respectively, sieve after mixing, and selectivity adds customary adjuvant, conveniently technique, makes acceptable preparation clinically.
8. preparation method as claimed in claim 6, is characterized in that, comprise the steps:
Get Rhizoma Dioscoreae, Fructus Momordicae charantiae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis according to selected parts by weight, pull out chinaroot greenbrier, Semen Cucurbitae, Cortex Lycii, Fructus Crataegi, Rhizoma Polygoni Cuspidati, Bombyx Batryticatus, Rhizoma Polygonati, Radix Rehmanniae Preparata, stone square rafter, wild mint, Poria and Rhizoma Alismatis, mixing, extracting in water, filters and collects filtrate, obtaining concentrated solution after concentrating under reduced pressure; Above-mentioned concentrated solution selectivity is added customary adjuvant, conveniently technique, make clinical acceptable preparation; Or
Get Rhizoma Dioscoreae, Fructus Momordicae charantiae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis according to selected parts by weight, pull out chinaroot greenbrier, Semen Cucurbitae, Cortex Lycii, Fructus Crataegi, Rhizoma Polygoni Cuspidati, Bombyx Batryticatus, Rhizoma Polygonati, Radix Rehmanniae Preparata, stone square rafter, wild mint, Poria and Rhizoma Alismatis, mixing, adds ethanol extraction, filters and collect filtrate, obtaining concentrated solution after concentrating under reduced pressure; Above-mentioned concentrated solution selectivity is added customary adjuvant, conveniently technique, make clinical acceptable preparation.
9. preparation method as claimed in claim 6, is characterized in that, comprise the steps:
(1) get wherein one or more raw material components mixing according to selected parts by weight, add alcohol reflux, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) again according to raw material components mixing under selected parts by weight remainder, direct extracting in water, or mix extracting in water again with the medicinal residues after alcohol extraction in step (1), filter and collect filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) above-mentioned concentrated solution selectivity is added customary adjuvant, conveniently technique, make clinical acceptable preparation.
10. the Chinese medicine composition for preparing of the arbitrary described Chinese medicine composition of claim 1-3 or the arbitrary described method of claim 6-9 is for the preparation of the purposes in treatment diabetes medicament.
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| CN106421374A (en) * | 2016-12-13 | 2017-02-22 | 四川西奈生物科技有限公司 | Traditional Chinese medicine composition for treating diabetes and application method thereof |
| CN111643596A (en) * | 2020-07-08 | 2020-09-11 | 常德市永春堂生物科技有限公司 | A Chinese medicinal composition for treating diabetes, and its preparation method |
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| CN111643596A (en) * | 2020-07-08 | 2020-09-11 | 常德市永春堂生物科技有限公司 | A Chinese medicinal composition for treating diabetes, and its preparation method |
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