CN110179117A - A kind of hypoglycemic particle electuary and preparation method thereof - Google Patents
A kind of hypoglycemic particle electuary and preparation method thereof Download PDFInfo
- Publication number
- CN110179117A CN110179117A CN201910633790.XA CN201910633790A CN110179117A CN 110179117 A CN110179117 A CN 110179117A CN 201910633790 A CN201910633790 A CN 201910633790A CN 110179117 A CN110179117 A CN 110179117A
- Authority
- CN
- China
- Prior art keywords
- parts
- hypoglycemic
- medical fluid
- enteromorpha
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002218 hypoglycaemic effect Effects 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000002245 particle Substances 0.000 title claims description 26
- 239000012530 fluid Substances 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 20
- 235000002722 Dioscorea batatas Nutrition 0.000 claims abstract description 19
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims abstract description 19
- 240000001811 Dioscorea oppositifolia Species 0.000 claims abstract description 19
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims abstract description 19
- 244000017020 Ipomoea batatas Species 0.000 claims abstract description 19
- 235000002678 Ipomoea batatas Nutrition 0.000 claims abstract description 19
- 244000234609 Portulaca oleracea Species 0.000 claims abstract description 19
- 235000001855 Portulaca oleracea Nutrition 0.000 claims abstract description 19
- 241000196252 Ulva Species 0.000 claims abstract description 19
- 241000233838 Commelina Species 0.000 claims abstract description 17
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 17
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 17
- 239000003814 drug Substances 0.000 claims abstract description 16
- 244000046146 Pueraria lobata Species 0.000 claims abstract description 15
- 235000010575 Pueraria lobata Nutrition 0.000 claims abstract description 15
- 239000008187 granular material Substances 0.000 claims abstract description 15
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 13
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 13
- 230000005484 gravity Effects 0.000 claims abstract description 7
- 239000002893 slag Substances 0.000 claims abstract description 7
- 238000001914 filtration Methods 0.000 claims abstract description 6
- 238000001694 spray drying Methods 0.000 claims abstract description 6
- 230000001954 sterilising effect Effects 0.000 claims abstract description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 5
- 239000000463 material Substances 0.000 claims abstract description 4
- 238000004140 cleaning Methods 0.000 claims abstract description 3
- 238000007654 immersion Methods 0.000 claims abstract description 3
- 238000002156 mixing Methods 0.000 claims description 6
- 238000011017 operating method Methods 0.000 claims description 2
- 244000228367 Lewisia rediviva Species 0.000 claims 1
- 235000007279 Lewisia rediviva Nutrition 0.000 claims 1
- 238000003756 stirring Methods 0.000 abstract description 5
- 239000000284 extract Substances 0.000 abstract description 4
- 206010012601 diabetes mellitus Diseases 0.000 description 17
- 239000008280 blood Substances 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 12
- 230000000694 effects Effects 0.000 description 10
- 239000008103 glucose Substances 0.000 description 8
- 235000000346 sugar Nutrition 0.000 description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 7
- 201000009104 prediabetes syndrome Diseases 0.000 description 7
- 206010018429 Glucose tolerance impaired Diseases 0.000 description 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 6
- 208000001280 Prediabetic State Diseases 0.000 description 6
- 230000023852 carbohydrate metabolic process Effects 0.000 description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
- 235000001014 amino acid Nutrition 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 229930003944 flavone Natural products 0.000 description 4
- 235000011949 flavones Nutrition 0.000 description 4
- 235000013376 functional food Nutrition 0.000 description 4
- 229930182478 glucoside Natural products 0.000 description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 235000018102 proteins Nutrition 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 238000007789 sealing Methods 0.000 description 4
- -1 thialdine alkane Chemical class 0.000 description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 241000219780 Pueraria Species 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 235000001465 calcium Nutrition 0.000 description 3
- 235000021256 carbohydrate metabolism Nutrition 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 150000002213 flavones Chemical class 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 235000001727 glucose Nutrition 0.000 description 3
- 150000008131 glucosides Chemical class 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- 229910052742 iron Inorganic materials 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 239000001103 potassium chloride Substances 0.000 description 3
- 235000011164 potassium chloride Nutrition 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 235000016068 Berberis vulgaris Nutrition 0.000 description 2
- 241000335053 Beta vulgaris Species 0.000 description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 2
- 102000004877 Insulin Human genes 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- ZQSIJRDFPHDXIC-UHFFFAOYSA-N daidzein Chemical compound C1=CC(O)=CC=C1C1=COC2=CC(O)=CC=C2C1=O ZQSIJRDFPHDXIC-UHFFFAOYSA-N 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 229940125396 insulin Drugs 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000011574 phosphorus Substances 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- 235000014786 phosphorus Nutrition 0.000 description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 1
- BBJUSJOGHYQDQX-WODDMCJRSA-N (2S)-4-[(E)-2-[(2S)-2-carboxy-5,6-dihydroxy-2,3-dihydroindol-1-yl]ethenyl]-2,3-dihydropyridine-2,6-dicarboxylic acid Chemical compound OC(=O)[C@@H]1Cc2cc(O)c(O)cc2N1\C=C\C1=CC(=N[C@@H](C1)C(O)=O)C(O)=O BBJUSJOGHYQDQX-WODDMCJRSA-N 0.000 description 1
- 239000001533 (4R,6S)-2,4,6-trimethyl-1,3,5-dithiazinane Substances 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- 102000040350 B family Human genes 0.000 description 1
- 108091072128 B family Proteins 0.000 description 1
- 229940123208 Biguanide Drugs 0.000 description 1
- 206010008132 Cerebral thrombosis Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 241000233839 Commelina communis Species 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 235000019750 Crude protein Nutrition 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- 208000002249 Diabetes Complications Diseases 0.000 description 1
- 206010012655 Diabetic complications Diseases 0.000 description 1
- 241000551547 Dione <red algae> Species 0.000 description 1
- 241000522215 Dipteryx odorata Species 0.000 description 1
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 208000002705 Glucose Intolerance Diseases 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 206010018473 Glycosuria Diseases 0.000 description 1
- 240000007058 Halophila ovalis Species 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000013016 Hypoglycemia Diseases 0.000 description 1
- 206010056997 Impaired fasting glucose Diseases 0.000 description 1
- 206010022489 Insulin Resistance Diseases 0.000 description 1
- 201000001429 Intracranial Thrombosis Diseases 0.000 description 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 102100024295 Maltase-glucoamylase Human genes 0.000 description 1
- 206010029164 Nephrotic syndrome Diseases 0.000 description 1
- 241000233855 Orchidaceae Species 0.000 description 1
- 241001560086 Pachyrhizus Species 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- RXUWDKBZZLIASQ-UHFFFAOYSA-N Puerarin Natural products OCC1OC(Oc2c(O)cc(O)c3C(=O)C(=COc23)c4ccc(O)cc4)C(O)C(O)C1O RXUWDKBZZLIASQ-UHFFFAOYSA-N 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 229940100389 Sulfonylurea Drugs 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 229930003471 Vitamin B2 Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- 108010028144 alpha-Glucosidases Proteins 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Natural products C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N benzo-alpha-pyrone Natural products C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- QXMNTPFFZFYQAI-IMDKZJJXSA-N beta-sitosterol 3-O-beta-D-glucopyranoside Natural products CC[C@H](CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)O[C@@H]5C[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)C(C)C QXMNTPFFZFYQAI-IMDKZJJXSA-N 0.000 description 1
- FPFIFCBPMJFKJR-LLVKDONJSA-M betanidin Natural products O=C([O-])[C+]1/[N+](=C/C=C/2\C=C(C(=O)O)N[C@@H](C(=O)O)C\2)/c2c(cc(O)c(O)c2)C1 FPFIFCBPMJFKJR-LLVKDONJSA-M 0.000 description 1
- 150000004283 biguanides Chemical class 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 229940097217 cardiac glycoside Drugs 0.000 description 1
- 239000002368 cardiac glycoside Substances 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 235000001671 coumarin Nutrition 0.000 description 1
- 150000004775 coumarins Chemical class 0.000 description 1
- 235000007240 daidzein Nutrition 0.000 description 1
- NPJICTMALKLTFW-OFUAXYCQSA-N daucosterol Chemical compound O([C@@H]1CC2=CC[C@H]3[C@@H]4CC[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@H](C)CC[C@@H](CC)C(C)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O NPJICTMALKLTFW-OFUAXYCQSA-N 0.000 description 1
- QDFKFNAHVGPRBL-UHFFFAOYSA-N daucosterol Natural products CCC(CCC(C)C1CCC2C1CCC3C2(C)CC=C4CC(CCC34C)OC5OC(CO)C(O)C(O)C5O)C(C)C QDFKFNAHVGPRBL-UHFFFAOYSA-N 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 150000005205 dihydroxybenzenes Chemical class 0.000 description 1
- MHUWZNTUIIFHAS-CLFAGFIQSA-N dioleoyl phosphatidic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC MHUWZNTUIIFHAS-CLFAGFIQSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229960003638 dopamine Drugs 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 244000309146 drought grass Species 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 150000002304 glucoses Chemical class 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 150000002337 glycosamines Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000003345 hyperglycaemic effect Effects 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 229960004502 levodopa Drugs 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000021281 monounsaturated fatty acids Nutrition 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 208000009928 nephrosis Diseases 0.000 description 1
- 231100001027 nephrosis Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 150000002871 norepinephrines Chemical class 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- LPMXVESGRSUGHW-HBYQJFLCSA-N ouabain Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)C[C@@H](O)[C@@H]3[C@@]2(CO)[C@H](O)C1 LPMXVESGRSUGHW-HBYQJFLCSA-N 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 1
- 230000000291 postprandial effect Effects 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- HKEAFJYKMMKDOR-VPRICQMDSA-N puerarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=CC(C2=O)=C1OC=C2C1=CC=C(O)C=C1 HKEAFJYKMMKDOR-VPRICQMDSA-N 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 229930002534 steroid glycoside Natural products 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/05—Chlorophycota or chlorophyta (green algae), e.g. Chlorella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Polymers & Plastics (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of hypoglycemic granules, are made in parts by weight of following components: 5-20 parts of dayflower, 5-20 parts of purslane, and 5-8 parts of sweet potato leaves, 3-7 parts of Enteromorpha, 1-5 parts of pueraria lobata, 1-5 parts of Chinese yam rhizome, 5-20 parts of microcrystalline cellulose.Preparation method is as follows: cleaning, shreds after dayflower, purslane, sweet potato leaves, Enteromorpha, pueraria lobata, Chinese yam rhizome score by weight are weighed, place immersion in water 30 minutes or more, is put into traditional Chinese medicine extracting machine decoction 2 hours or more and extracts medical fluid;It adds water decoction 1 hour or more and extracts medical fluid;Merge filtering and removing slag after extracting medical fluid twice, low temperature is concentrated into specific gravity when being 1.2-1.5, and microcrystalline cellulose auxiliary material is added, stirs evenly and is placed on spray-drying pelleting machine granule granule is made, then sterilization treatment, sealed package.
Description
Technical field
The present invention relates to a kind of hypoglycemic particle electuaries, belong to technical field of functional food.
Background technique
In the global diabetes report of World Health Organization's publication in 2016, global diabetes adult patient nearly 40 is shown
3 times are increased in year, wherein majority lives in developing country.
It defends in the data that planning commission issues and recognizes from country in 2017, China has adult more than half and is in sugar
Sick early period is urinated, the high-incidence impetus of diabetes is not obviously contained.China's diabetic's quantity occupies first place in the world, illness rate
Up to 11.6%, there is 50.1% adult to be in prediabetes, be likely to become new diabetic at any time.Glycosuria
Sick early period is a kind of state between diabetes and euglycemia, and glycometabolism adjusting is in damaged condition, shows as fasting blood-glucose
5.6-7.0 mol/L (impaired fasting glucose) or postprandial blood sugar 7.8-11.1 mol/L (impaired glucose tolerance).If these are sugared
The people for urinating sick early period passed through diet modification and physical training, and most people can avoid developing into diabetes patient.
Mainly use for the treatment of diabetes patient at present: sulfonylurea drugs, biguanides, alpha-glucosidase press down
Preparation, thialdine alkane diones drug, insulin.And for the crowd of prediabetes, also usually using this kind of drug, caused
Spend medical phenomenon.Western medicine often will appear the serious side effect such as hypoglycemia based on hypoglycemic, and to diabetic complication
Not good therapeutic effect.In addition, Western medicine human body multipair greatly has stronger toxic side effect, the long-term liver taken to human body, renal damage
Seriously.And insulin is used for a long time and easily causes insulin resistance, and cerebral thrombosis, apoplexy, heart attack, nephrosis can be caused comprehensive
Disease etc. jeopardizes the life of patient.
For the above problem in treating diabetes, starting point of the invention is for prediabetes crowd and diabetes patient
A kind of functional food that the composition by natural food and medicament dual-purpose is made is provided, human body function carbohydrate metabolism, safe nothing is adjusted
Side effect, the functional food of this auxiliary hyperglycemic using natural products development, be alleviate the high-incidence approach of diabetes it
One.
Summary of the invention
The object of the present invention is to provide a kind of punchings of the hypoglycemic particle of suitable prediabetes crowd and diabetes patient
Agent, it is convenient, human body function carbohydrate metabolism is adjusted, safety is without any side effects.
Realize the purpose of foregoing invention, the technical solution adopted by the present invention is as follows:
A kind of hypoglycemic particle electuary, which is characterized in that be made in parts by weight of following components:
5-20 parts of dayflower, 5-20 parts of purslane, 5-8 parts of sweet potato leaves, 3-7 parts of Enteromorpha are 1-5 parts of pueraria lobata, 1-5 parts of Chinese yam rhizome, micro-
5-20 parts of crystalline cellulose.
A kind of preparation method of above-mentioned hypoglycemic particle electuary, including following operating procedure:
Step 1: cleaning, shred after dayflower, purslane, sweet potato leaves, Enteromorpha, pueraria lobata, Chinese yam rhizome score by weight are weighed, put
It sets immersion in water 30 minutes or more, is put into traditional Chinese medicine extracting machine decoction 2 hours or more, takes out medical fluid;Add water decoction 1 hour with
On, take out medical fluid;
Step 2: filtering and removing slag after the medical fluid taken out twice in step 1 is merged, it is 1.2-1.5 that medical fluid low temperature, which is concentrated into specific gravity,
When, the microcrystalline cellulose as auxiliary material is added in parts by weight, granule granule is made after mixing evenly, then sterilizes, seal packet
Dress.
Above-mentioned hypoglycemic particle electuary is added in hot water when use and takes after mixing it with water, convenient.
The hypoglycemic particle electuary of the present invention is by dayflower, purslane, sweet potato leaves, Enteromorpha, pueraria lobata, Chinese yam rhizome, microcrystalline cellulose
Element forms in parts by weight, it has been investigated that, said components do not have effects that as follows: (one), dayflower scientific name Commelina
Communis L. belongs to Commelianaceae spring annual grassy weeds.Alias Orchid, bamboo grass etc..It is northern each province important spring
Annual grassy weeds is then perennial weeds in the southern each province such as Guangdong, and this product nature and flavor sweetness and bitterness is cold, enters lung, stomach, bladder meridian has
Clearing heat-fire, removing toxic substances, the effect of Li Shui.This laboratory finds that herb water decoction has hypoglycemic effect in an experiment.(2),
Purslane is edible edible wild herbs, and herb is containing a large amount of norepinephrines and volume sylvite (including potassium nitrate, potassium chloride, sulphur
Sour potassium and other sylvite).Also containing DOPA, dopamine, betanidin, isobetanidin, beet glucoside, different beet glucoside, oxalic acid, malic acid,
Citric acid, glutamic acid, aspartic acid, alanine and glucose, fructose, sucrose etc..Herb shows alkaloid, tonka-bean according to another report
The reaction of essence, flavones, cardiac glycoside and anthracene glucoside.And containing a large amount of poly- 3 unsaturated fatty acid of ω.Purslane has a variety of physiology function
Can, contained by Polysaccharide from Portulaca oleracea polysaccharide have the function of reduction blood glucose, in addition gone on first kidney in purslane containing high concentration
Parathyrine and dihydroxy benzenes ethamine (precursor of norepinephrine), can glycometabolism process in adjusting body, promote pancreatic secretion pancreas islet
Element achievees the effect that hypoglycemic.(3), sweet potato leaves contain sweet potato leaves flavones, mucus albumen, there are also carrotene very abundant and
Dietary fiber, the microelements such as vitamin B2, vitamin C and calcium, phosphorus, iron, sweet potato leaves flavones have reducing blood lipid, hypoglycemic
Effect, modern clinical research discovery, pachyrhizus leaf have the function for the treatment of diabetes.(4), Enteromorpha is rich in carbohydrate, albumen
Matter, crude fibre and minerals, while also containing fat and vitamin.In enteromorpha protein matter, amino acid classes are complete, it is necessary to ammonia
Base acid content is higher.In the fatty acid composition of Enteromorpha, polyunsaturated fatty acid, monounsaturated fatty acids and saturated fatty acid contain
Amount is is respectively 50.5%, 12.7% and 36.8%, including nearly 4% odd carbon fatty acid.Sea grass polysaccharide has hypoglycemic
Effect.(5), pueraria lobata is also a kind of Chinese medicine of relatively common food and medicine consangunity, is a kind of often feeding vegetable of some provinces and regions in south
Dish.Its main component is starch, furthermore contains about 12% flavone compound, including soybean (soya bean) glucoside, daidzein, Pueraria lobota
Root element etc. more than 10;And contain Daucosterol, amino acid, Coumarins etc.;There are also protein, amino acid, sugar and needed by human
The minerals such as iron, calcium, copper, selenium, be rare invigorant suitable for people of all ages.Modern science proves that Puerarin has blood sugar reducing function.
(6), Chinese yam rhizome Chinese yam rhizome as high-nutrition food contain a large amount of protein, carbohydrate, B family vitamin, vitamin C, vitamin E,
The indispensable inorganic salts of human bodies and the micro member such as glucose, crude protein amino acid, bile alkaline, allantoin and iodine, calcium, iron, phosphorus
The nutritional ingredients such as element, a large amount of mucin is contained in Chinese yam rhizome, and mucin has effect to treatment hypertension, hyperglycemia.
The hypoglycemic particle electuary of the present invention is made of the component of above-mentioned integration of drinking and medicinal herbs, and the microcrystalline cellulose of addition is also a kind of
It is usually used in the auxiliary material of drug, safe and non-toxic, this hypoglycemic electuary is very suitable to the experiment proved that with good blood sugar decreasing effect
Prediabetes crowd and diabetes patient also have enriching yin and nourishing kidney, balance yin while adjusting human body function carbohydrate metabolism
Sun, correct sugar, protein, the metabolic disorders such as fat effect, taken after mixing it with water when use in addition hot water, it is convenient.
Specific embodiment
Embodiment 1
A kind of hypoglycemic particle electuary, by following components by weight parts numeral system at: 10 parts of dayflower, 7 parts of purslane, sweet potato leaves 5
Part, 4 parts of Enteromorpha, 3 parts of pueraria lobata, 1 part of Chinese yam rhizome, 15 parts of microcrystalline cellulose.
The hypoglycemic particle electuary of this implementation 1 the preparation method is as follows: will be by dayflower, purslane, sweet potato leaves, Enteromorpha, Pueraria lobota
Root, Chinese yam rhizome score by weight are cleaned after weighing, are shredded, and are placed in pure water and are impregnated 60 minutes, are put into traditional Chinese medicine extracting machine and are decocted
It boils 2 hours or more, takes out medical fluid;It adds water decoction 1 hour or more, takes out medical fluid;The medical fluid extracted twice is crossed after merging and is filtered out
Slag, by medical fluid low temperature be concentrated into specific gravity be 1.3 when, 15 parts of microcrystalline celluloses are added, stirs evenly and is placed on spray-drying process
Granule granule is made in machine, then sterilizes, pack sealing.
Embodiment 2
A kind of hypoglycemic particle electuary, by following components by weight parts numeral system at: 15 parts of dayflower, 8 parts of purslane, sweet potato leaves 5
Part, 3 parts of Enteromorpha, 2 parts of pueraria lobata, 2 parts of Chinese yam rhizome, 18 parts of microcrystalline cellulose.
The hypoglycemic particle electuary of this implementation 2 the preparation method is as follows:
It clean, shred after dayflower, purslane, sweet potato leaves, Enteromorpha, pueraria lobata, Chinese yam rhizome score by weight being weighed, be placed on
It is impregnated 60 minutes in pure water, is put into traditional Chinese medicine extracting machine and decocts 2 hours, take out medical fluid;Decoction 1 hour is added water, medical fluid is taken out;
18 parts of microcrystalline celluloses are added when to be concentrated into specific gravity be 1.4 by medical fluid low temperature in filtering and removing slag after the medical fluid that extracts twice merges,
It stirs evenly and is placed on spray-drying pelleting machine granule granule is made, then sterilize, pack sealing.
Embodiment 3
A kind of hypoglycemic particle electuary, by following components by weight parts numeral system at: 10 parts of dayflower, take 10 parts of purslane, sweet potato
6 parts of leaf, 7 parts of Enteromorpha, 2 parts of pueraria lobata, 2 parts of Chinese yam rhizome, 19 parts of microcrystalline cellulose.
The hypoglycemic particle electuary of this implementation 3 the preparation method is as follows:
It clean, shred after dayflower, purslane, sweet potato leaves, Enteromorpha, pueraria lobata, Chinese yam rhizome score by weight being weighed, be placed on
It is impregnated 80 minutes in pure water, is put into traditional Chinese medicine extracting machine and decocts 2 hours, take out medical fluid;Decoction 1 hour is added water, medical fluid is taken out;
19 parts of microcrystalline celluloses are added when to be concentrated into specific gravity be 1.2 by medical fluid low temperature in filtering and removing slag after the medical fluid that extracts twice merges,
It stirs evenly and is placed on spray-drying pelleting machine granule granule is made, then sterilize, pack sealing.
Embodiment 4
A kind of hypoglycemic particle electuary, by following components by weight parts numeral system at dayflower, 15 parts, 10 parts of purslane, sweet potato leaves
4 parts, 2 parts of Enteromorpha, 5 parts of pueraria lobata, 4 parts of Chinese yam rhizome, 20 parts of microcrystalline cellulose.
The hypoglycemic particle electuary of this implementation 4 the preparation method is as follows: will be by dayflower, purslane, sweet potato leaves, Enteromorpha, Pueraria lobota
Root, Chinese yam rhizome score by weight are cleaned after weighing, are shredded, and are placed in pure water and are impregnated 60 minutes, are put into traditional Chinese medicine extracting machine and are decocted
It boils 2 hours, takes out medical fluid;Decoction 1 hour is added water, medical fluid is taken out;Filtering and removing slag after the medical fluid extracted twice merges, by medical fluid
Low temperature is concentrated into specific gravity when being 1.3, and 20 parts of microcrystalline celluloses are added, stirs evenly and is placed on spray-drying pelleting machine electuary is made
Then particle sterilizes, pack sealing.
Above-described embodiment 1 is into embodiment 4, and in the preparation method of hypoglycemic particle electuary, sterilization treatment uses tunnel type
The sterilizing of microwave sterilization machine.
A kind of hypoglycemic particle electuary of the present invention has carried out hypoglycemic effect test:
1,20 diabetes volunteers are chosen, each volunteer's blood glucose is detected.
2, method of administration: three times a day, each taking 10g, adding mixing in water for oral taking, even served for 1 Zhou Weiyi period.It is treated for one within one month
Journey.
3. the blood glucose of detection in every two days.
4. measurement result:
(1) 20 patient takes one week measurement result: having 14 blood glucose to reduce, wherein 8 blood glucose are reduced to normally;
(2) 20 patients take one month measurement result, and 19 patient blood glucoses are normal, and only an example only slightly decreases.This
Electuary has no toxic side effect in volunteer in, does not find adverse reaction.
In conclusion the hypoglycemic particle electuary of the present invention has good blood sugar decreasing effect, this product is as auxiliary drop blood
Sugar functional food, be very suitable to prediabetes crowd and diabetes patient, can be used as alleviate diabetes it is high-incidence one
Kind effective way.
Claims (5)
1. a kind of hypoglycemic particle electuary, which is characterized in that be made in parts by weight of following components: 5-20 parts of dayflower, horse
5-20 parts of bitterroot, 5-8 parts of sweet potato leaves, 3-7 parts of Enteromorpha, 1-5 parts of pueraria lobata, 1-5 parts of Chinese yam rhizome, 5-20 parts of microcrystalline cellulose.
2. a kind of hypoglycemic particle electuary according to claim 1, which is characterized in that by following components numeral system by weight
At: 10 parts of dayflower, 7 parts of purslane, 5 parts of sweet potato leaves, 4 parts of Enteromorpha, 3 parts of pueraria lobata, 1 part of Chinese yam rhizome, 15 parts of microcrystalline cellulose.
3. a kind of hypoglycemic particle electuary according to claim 1, preparation method includes following operating procedure:
Step 1: cleaning, shred after dayflower, purslane, sweet potato leaves, Enteromorpha, pueraria lobata, Chinese yam rhizome score by weight are weighed, put
It sets immersion in water 30 minutes or more, is put into traditional Chinese medicine extracting machine decoction 2 hours or more, takes out medical fluid;Add water decoction 1 hour with
On, take out medical fluid;
Step 2: filtering and removing slag after the medical fluid taken out twice in step 1 is merged, it is 1.2-1.5 that medical fluid low temperature, which is concentrated into specific gravity,
When, microcrystalline cellulose as auxiliary material is added in parts by weight, granule granule is made after mixing evenly, then sterilization treatment, close
Package dress.
4. the preparation method of a kind of hypoglycemic particle electuary according to claim 3, it is characterized in that: microcrystalline cellulose is added
Medical fluid after mixing evenly is placed in spray-drying pelleting machine and granule granule is made.
5. the preparation method of a kind of hypoglycemic particle electuary according to claim 3, it is characterized in that: the sterilization treatment
It is sterilized using tunnel type micro wave sterilizer.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910633790.XA CN110179117A (en) | 2019-07-15 | 2019-07-15 | A kind of hypoglycemic particle electuary and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910633790.XA CN110179117A (en) | 2019-07-15 | 2019-07-15 | A kind of hypoglycemic particle electuary and preparation method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN110179117A true CN110179117A (en) | 2019-08-30 |
Family
ID=67725713
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201910633790.XA Pending CN110179117A (en) | 2019-07-15 | 2019-07-15 | A kind of hypoglycemic particle electuary and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN110179117A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110327450A (en) * | 2019-07-23 | 2019-10-15 | 青岛市市立医院 | A kind of protection gastric mucosa particle electuary and preparation method thereof |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6551627B1 (en) * | 2001-05-03 | 2003-04-22 | Holomed Pharmaceuticals, Ltd. | Medicinal herbal compounds for the prevention and treatment of diabetes |
CN101167781A (en) * | 2007-11-09 | 2008-04-30 | 燕山大学 | Orally-administered hypoglycemic sweet potato leaf single prescription traditional Chinese medicine and preparation method thereof |
CN101745048A (en) * | 2010-02-26 | 2010-06-23 | *** | Medicine for treating type II diabetes and resisting aging |
CN102784305A (en) * | 2012-03-20 | 2012-11-21 | 河南九势制药股份有限公司 | Traditional Chinese medicine composition for assisting in decreasing blood sugar and preparation method of traditional Chinese medicine composition |
CN103845607A (en) * | 2013-11-27 | 2014-06-11 | 吉林省中医药科学院 | Compound traditional Chinese medicinal preparation for preventing and treating diabetes mellitus and preparation method thereof |
CN105106276A (en) * | 2015-09-23 | 2015-12-02 | 刘高志 | Tradescantia extract as well as preparation method and medical application of tradescantia extract |
CN108003199A (en) * | 2017-07-12 | 2018-05-08 | 中国科学院过程工程研究所 | A kind of Enteromorpha oligosaccharide with function of blood sugar reduction and its preparation method and application |
CN109527562A (en) * | 2018-12-18 | 2019-03-29 | 李家文 | Sweet potato leaves plant pancreas islet powder and preparation method |
-
2019
- 2019-07-15 CN CN201910633790.XA patent/CN110179117A/en active Pending
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6551627B1 (en) * | 2001-05-03 | 2003-04-22 | Holomed Pharmaceuticals, Ltd. | Medicinal herbal compounds for the prevention and treatment of diabetes |
CN101167781A (en) * | 2007-11-09 | 2008-04-30 | 燕山大学 | Orally-administered hypoglycemic sweet potato leaf single prescription traditional Chinese medicine and preparation method thereof |
CN101745048A (en) * | 2010-02-26 | 2010-06-23 | *** | Medicine for treating type II diabetes and resisting aging |
CN102784305A (en) * | 2012-03-20 | 2012-11-21 | 河南九势制药股份有限公司 | Traditional Chinese medicine composition for assisting in decreasing blood sugar and preparation method of traditional Chinese medicine composition |
CN103845607A (en) * | 2013-11-27 | 2014-06-11 | 吉林省中医药科学院 | Compound traditional Chinese medicinal preparation for preventing and treating diabetes mellitus and preparation method thereof |
CN105106276A (en) * | 2015-09-23 | 2015-12-02 | 刘高志 | Tradescantia extract as well as preparation method and medical application of tradescantia extract |
CN108003199A (en) * | 2017-07-12 | 2018-05-08 | 中国科学院过程工程研究所 | A kind of Enteromorpha oligosaccharide with function of blood sugar reduction and its preparation method and application |
CN109527562A (en) * | 2018-12-18 | 2019-03-29 | 李家文 | Sweet potato leaves plant pancreas islet powder and preparation method |
Non-Patent Citations (1)
Title |
---|
谭志荣,等: "鸭跖草水提取物降血糖作用的实验研究", 《中国热带医学》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110327450A (en) * | 2019-07-23 | 2019-10-15 | 青岛市市立医院 | A kind of protection gastric mucosa particle electuary and preparation method thereof |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102919836B (en) | Health-care product capable of reducing blood glucose, releasing pressure, reducing lipid, relaxing bowel, beautifying, losing weight and resisting fatigue and production process thereof | |
CN103099089B (en) | Health-care product for reducing blood sugar and blood pressure, relaxing bowels, losing weight, resisting fatigue and improving sexual function and production technology thereof | |
KR101738912B1 (en) | Composition For Anti-obesity And Diet | |
CN103190659A (en) | Plant beverage with pressure-drop, lipid-reducing, and hypoglycemic effects as well as preparation method and application thereof | |
CN106509261A (en) | Sugar-free herbal tea plant composition, and method for preparing drink and granule from composition | |
CN104543834A (en) | Pumpkin powder with blood sugar reducing effect and preparation method thereof | |
CN107822040A (en) | A kind of preparation method of rhizoma zingiberis cinnamon health care jelly | |
CN103040054A (en) | Garlic functional drink and preparation method thereof | |
CN102038260A (en) | Chinese medicinal alcoholism relieving health-care beverage and preparation method thereof | |
CN101543295B (en) | Health care tea for reducing blood pressure and blood fat | |
CN106578077A (en) | Milk tea containing kelp dietary fibers and preparation method thereof | |
CN102113534B (en) | Moon cake with function of treating diabetes and preparation method thereof | |
CN105267755A (en) | Blood-glucose-reducing oral liquid | |
CN101099526B (en) | Ginseng flower health tea drink and its preparing method | |
CN104106828A (en) | Solid beverage for reducing blood glucose | |
CN103263054B (en) | Functional drink capable of reducing blood pressure | |
CN107802770A (en) | Balance the Chinese medicine and health products of metabolic system radical cure early stage type II diabetes | |
CN110179117A (en) | A kind of hypoglycemic particle electuary and preparation method thereof | |
CN101243878B (en) | Health care pear syrup | |
CN104905364A (en) | Beverage capable of reducing blood sugar and preparation method thereof | |
CN102132929B (en) | Preparation method of fig granule | |
CN1943448A (en) | Bamboo juice and ginkgo drink and its producing method | |
CN106421491A (en) | Formula of radix helicteris oral liquid with blood glucose reducing effect and preparation method | |
CN103271402B (en) | Functional beverage for reducing blood sugar | |
CN102630997B (en) | Tartary buckwheat beverage and making method thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190830 |
|
WD01 | Invention patent application deemed withdrawn after publication |