CN102579788B - Medicinal composition for treating peptic ulcer - Google Patents
Medicinal composition for treating peptic ulcer Download PDFInfo
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- CN102579788B CN102579788B CN 201210076982 CN201210076982A CN102579788B CN 102579788 B CN102579788 B CN 102579788B CN 201210076982 CN201210076982 CN 201210076982 CN 201210076982 A CN201210076982 A CN 201210076982A CN 102579788 B CN102579788 B CN 102579788B
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- radix
- peptic ulcer
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- 208000008469 Peptic Ulcer Diseases 0.000 title claims abstract description 14
- 208000011906 peptic ulcer disease Diseases 0.000 title claims abstract description 14
- 239000000203 mixture Substances 0.000 title abstract description 8
- 239000004863 Frankincense Substances 0.000 claims abstract description 4
- 235000000177 Indigofera tinctoria Nutrition 0.000 claims abstract 2
- 241000206469 Pulsatilla Species 0.000 claims abstract 2
- 229940097275 indigo Drugs 0.000 claims abstract 2
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 6
- 239000004615 ingredient Substances 0.000 claims description 4
- 241000717739 Boswellia sacra Species 0.000 claims description 3
- 241000628997 Flos Species 0.000 claims description 3
- 241001057584 Myrrha Species 0.000 claims description 3
- 239000009286 sanguis draxonis Substances 0.000 claims description 3
- QQILFGKZUJYXGS-UHFFFAOYSA-N Indigo dye Chemical compound C1=CC=C2C(=O)C(C3=C(C4=CC=CC=C4N3)O)=NC2=C1 QQILFGKZUJYXGS-UHFFFAOYSA-N 0.000 claims description 2
- 239000009806 pulsatillae Substances 0.000 claims description 2
- 241000202807 Glycyrrhiza Species 0.000 claims 2
- 241001529739 Prunella <angiosperm> Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 3
- 235000003717 Boswellia sacra Nutrition 0.000 abstract 1
- 240000007551 Boswellia serrata Species 0.000 abstract 1
- 235000012035 Boswellia serrata Nutrition 0.000 abstract 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 abstract 1
- 244000020518 Carthamus tinctorius Species 0.000 abstract 1
- 240000007311 Commiphora myrrha Species 0.000 abstract 1
- 235000006965 Commiphora myrrha Nutrition 0.000 abstract 1
- 241000830535 Ligustrum lucidum Species 0.000 abstract 1
- 241000234435 Lilium Species 0.000 abstract 1
- 235000007265 Myrrhis odorata Nutrition 0.000 abstract 1
- 244000170916 Paeonia officinalis Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 241000972672 Phellodendron Species 0.000 abstract 1
- 244000179560 Prunella vulgaris Species 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 241001180876 Saposhnikovia Species 0.000 abstract 1
- 240000004824 Trimezia steyermarkii Species 0.000 abstract 1
- 235000005272 common selfheal Nutrition 0.000 abstract 1
- 239000009136 dragon's blood Substances 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 description 7
- 231100000397 ulcer Toxicity 0.000 description 7
- 208000024891 symptom Diseases 0.000 description 4
- 238000002575 gastroscopy Methods 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- 206010000087 Abdominal pain upper Diseases 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000007919 dispersible tablet Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002183 duodenal effect Effects 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 208000002551 irritable bowel syndrome Diseases 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a medicinal composition for treating peptic ulcer. The medicinal composition is prepared from divaricate saposhnikovia root, Chinese pulsatilla root, common selfheal fruit-spike, frankincense, natural indigo, liquoric root, myrrh, phellodendron, white paeony root, lily, grassleaf sweelflag rhizome, safflower, rehmannia root, glossy privet fruit and dragon's blood. The medicinal composition for treating peptic ulcer has simple and readily available components and an obvious curative effect, and does not have an obvious side effect.
Description
Technical field
The present invention relates to field of medicaments, particularly, the present invention relates to a kind of pharmaceutical composition for the treatment of peptic ulcer.
Background technology
Peptic ulcer is sometimes referred to as ulcer.Originally the gastric acid (hydrochloric acid) of digest food and pepsin (enzyme a kind of) have but digested coat of the stomach and the duodenal wall of self, thus the damage mucous membrane tissue, and this is the main cause of initiation peptic ulcer.
Summary of the invention
The purpose of this invention is to provide a kind of pharmaceutical composition for the treatment of peptic ulcer.
In order to realize purpose of the present invention, the invention provides a kind of pharmaceutical composition for the treatment of peptic ulcer, it is the medicament of being made according to weight proportion by following ingredients:
Preferably, the pharmaceutical composition for the treatment of peptic ulcer of the present invention is the medicament of being made according to weight proportion by following ingredients:
The pharmaceutical composition for the treatment of peptic ulcer of the present invention can be made various dosage forms according to technological means well-known to those skilled in the art, such as tablet (dispersible tablet), capsule, hard capsule, decoction etc.
The drug regimen composition formula for the treatment of peptic ulcer of the present invention is reasonable, and composition is simple and easy to, and is evident in efficacy, and do not have an obvious side effect.
The specific embodiment
The following examples will be further described the present invention, but not thereby limiting the invention.
The preparation of embodiment 1 tablet of the present invention
Get Radix Saposhnikoviae 500 grams, the Radix Pulsatillae 300 grams, Spica Prunellae 2000 grams, Olibanum 500 grams, Indigo Naturalis 2000 grams, Radix Glycyrrhizae 500 grams, Myrrha 300 grams, Cortex Phellodendri 1000 grams, the Radix Paeoniae Alba 1500 grams, Bulbus Lilii 300 grams, Rhizoma Acori Graminei 1500 grams, Flos Carthami 300 grams, the Radix Rehmanniae 1000 grams, Fructus Ligustri Lucidi 300 grams, Sanguis Draxonis 300 grams, pulverizer is pulverized, cross 80 mesh sieves, add microcrystalline Cellulose 3000 grams, mannitol 1000 grams, mix homogeneously, amidin pelletize with 10 % by weight, dry rear and crospolyvinylpyrrolidone 500 gram mix homogeneously are pressed 1000.
Test example
Diagnostic criteria
Upper abdominal pain is cardinal symptom, and that the pain feature is is chronic, periodically and rhythmicity, with belch, acid regurgitation, feel sick, dyspepsia and the irritable bowel syndrome such as vomiting.Gastroscopy: how rounded ulcer is or oval, and diameter is less than 1cm, neat in edge, and the bottom is full of lark or oozes thing from color, and mucosa can have swelling congested on every side, sees that sometimes the wrinkle wall concentrates to ulcer.X-ray barium meal examination: direct sign, niche.Without complication and canceration.
Choose patient's 40 examples that meet above-mentioned standard, male 20 examples, women 20 examples, the oldest person is 60 years old, reckling is 28 years old, average 41 years old.
Use the tablet of embodiment 1 preparation to treat every day 3 times, each 3.Treatment is 10 days continuously.
Criterion of therapeutical effect
1 recovery from illness: clinical symptoms complete obiteration; Gastroscopy: ulcer periphery inflammation disappears, and mucosa is newborn, and ulcer shoals and diminishes or the formation of ulcer kitchen range granulation; X-ray shows: niche disappears.2 is effective: clinical symptom remission, and Upper abdominal pain obviously alleviates; Gastroscopy: ulcer periphery mucous hyperemia edema alleviates, and exudate reduces; X-ray shows: the niche area reducing.3 is invalid: clinical symptoms, gastroscope and x-ray inspection are front without improving or increasing the weight of.：
Through the treatment of a course for the treatment of, find that all patients all meets the standard of recovery from illness, and in therapeutic process, do not find untoward reaction.
Claims (2)
1. a pharmaceutical composition for the treatment of peptic ulcer is characterized in that, it is the medicament of being made according to weight proportion by following ingredients:
Radix Saposhnikoviae 1～10 weight portion Radix Pulsatillae 1～5 weight portion Spica Prunellae 10～30 weight portions
Olibanum 1～10 weight portion Indigo Naturalis 10～30 weight portion Radix Glycyrrhizaes 1～10 weight portion
Myrrha 1～5 weight portion Cortex Phellodendri 5～15 weight portion Radix Paeoniae Albas 10～20 weight portions
Bulbus Lilii 1～5 weight portion Rhizoma Acori Graminei 10～20 weight portion Flos Carthamis 1～5 weight portion
The Radix Rehmanniae 5～15 weight portion Fructus Ligustri Lucidi 1～5 weight portion Sanguis Draxonis 1～5 weight portion.
2. the pharmaceutical composition for the treatment of peptic ulcer according to claim 1 is characterized in that, it is the medicament of being made according to weight proportion by following ingredients:
The Radix Saposhnikoviae 5 weight portion Radix Pulsatillaes 3 weight portion Spica Prunellaes 20 weight portions
Olibanum 5 weight portion Indigo Naturaliss 20 weight portion Radix Glycyrrhizaes 5 weight portions
The Myrrha 3 weight portion Cortex Phellodendris 10 weight portion Radix Paeoniae Albas 15 weight portions
Bulbus Lilii 3 weight portion Rhizoma Acori Graminei 15 weight portion Flos Carthamis 3 weight portions
The Radix Rehmanniae 10 weight portion Fructus Ligustri Lucidi 3 weight portion Sanguis Draxonis 3 weight portions.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210076982 CN102579788B (en) | 2012-03-22 | 2012-03-22 | Medicinal composition for treating peptic ulcer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210076982 CN102579788B (en) | 2012-03-22 | 2012-03-22 | Medicinal composition for treating peptic ulcer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102579788A CN102579788A (en) | 2012-07-18 |
| CN102579788B true CN102579788B (en) | 2013-05-29 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201210076982 Expired - Fee Related CN102579788B (en) | 2012-03-22 | 2012-03-22 | Medicinal composition for treating peptic ulcer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102579788B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103157088A (en) * | 2013-03-22 | 2013-06-19 | 徐保东 | Medicament for treating peptic ulcer |
| CN105169280A (en) * | 2015-10-13 | 2015-12-23 | 青岛辰达生物科技有限公司 | Traditional Chinese medicine composition for treating duodenal ulcer complicated with ulcerative colitis |
| CN105267940A (en) * | 2015-12-02 | 2016-01-27 | 青岛友诚高新技术有限公司 | Traditional Chinese medicine composition for preventing and treating gastric ulcer and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1169561C (en) * | 2002-05-16 | 2004-10-06 | 高学山 | Medicine for treating diseases of rectum and anus |
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2012
- 2012-03-22 CN CN 201210076982 patent/CN102579788B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN102579788A (en) | 2012-07-18 |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
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| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: TIANJIANG PHARMACEUTICAL INDUSTRY CO., LTD., JIANG Free format text: FORMER OWNER: JIE RUIDONG Effective date: 20130808 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 272300 JINING, SHANDONG PROVINCE TO: 214400 WUXI, JIANGSU PROVINCE |
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| TR01 | Transfer of patent right |
Effective date of registration: 20130808 Address after: 214400 Jiangyin Economic Development Zone, Jiangsu, Qin Shan Road, No. 8 Patentee after: Tianjiang Pharmaceutical Industry Co., Ltd., Jiangyin Address before: 272300 Shandong province Yutai County, micro Lake Court Building 5 unit 2 Room 201 Patentee before: Jie Ruidong |
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| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20160617 Address after: 200331 2948, room 105, 2891 lane, South Qilian Mountains Road, Shanghai, Putuo District Patentee after: Shanghai rich medical technology Co., Ltd. Address before: 214400 Jiangyin Economic Development Zone, Jiangsu, Qin Shan Road, No. 8 Patentee before: Tianjiang Pharmaceutical Industry Co., Ltd., Jiangyin |
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| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20160818 Address after: 201209 Shanghai city Pudong New Area Sichuan Road No. 6251 building 11 Room 309 Patentee after: Shanghai Jingyuan Investment Co., Ltd. Address before: 200331 2948, room 105, 2891 lane, South Qilian Mountains Road, Shanghai, Putuo District Patentee before: Shanghai rich medical technology Co., Ltd. |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130529 Termination date: 20180322 |
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| CF01 | Termination of patent right due to non-payment of annual fee |