CN102483418B - 先兆子痫检测和治疗的方法和组合物 - Google Patents
先兆子痫检测和治疗的方法和组合物 Download PDFInfo
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- CN102483418B CN102483418B CN200980153533.0A CN200980153533A CN102483418B CN 102483418 B CN102483418 B CN 102483418B CN 200980153533 A CN200980153533 A CN 200980153533A CN 102483418 B CN102483418 B CN 102483418B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/6857—Antibody fragments
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6866—Interferon
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4703—Regulators; Modulating activity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
- G01N2333/8121—Serpins
- G01N2333/8125—Alpha-1-antitrypsin
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/902—Oxidoreductases (1.)
- G01N2333/90287—Oxidoreductases (1.) oxidising metal ions (1.16)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/36—Gynecology or obstetrics
- G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
Abstract
Description
Claims (7)
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910197437.1A CN110187121B (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
CN201710342959.7A CN107677828A (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
CN201710343423.7A CN107677830A (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
CN201410747896.XA CN105021821B (zh) | 2008-10-31 | 2009-11-02 | 先兆子痫检测和治疗的方法和组合物 |
CN201410747937.5A CN104777307B (zh) | 2008-10-31 | 2009-11-02 | 先兆子痫检测和治疗的方法和组合物 |
CN201410747689.4A CN105044347B (zh) | 2008-10-31 | 2009-11-02 | 先兆子痫检测和治疗的方法和组合物 |
CN201910197165.5A CN110187120B (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
CN201710343422.2A CN107677829A (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
CN201410748445.8A CN104777308B (zh) | 2008-10-31 | 2009-11-02 | 先兆子痫检测和治疗的方法和组合物 |
CN201910197424.4A CN110208540B (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
CN201910197163.6A CN110187119B (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19791408P | 2008-10-31 | 2008-10-31 | |
US61/197,914 | 2008-10-31 | ||
US20653409P | 2009-01-29 | 2009-01-29 | |
US61/206,534 | 2009-01-29 | ||
PCT/US2009/005957 WO2010062377A2 (en) | 2008-10-31 | 2009-11-02 | Methods and compositions for the detection and treatment of preeclampsia |
Related Child Applications (11)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410747896.XA Division CN105021821B (zh) | 2008-10-31 | 2009-11-02 | 先兆子痫检测和治疗的方法和组合物 |
CN201910197424.4A Division CN110208540B (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
CN201710343422.2A Division CN107677829A (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
CN201710342959.7A Division CN107677828A (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
CN201710343423.7A Division CN107677830A (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
CN201910197165.5A Division CN110187120B (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
CN201410747689.4A Division CN105044347B (zh) | 2008-10-31 | 2009-11-02 | 先兆子痫检测和治疗的方法和组合物 |
CN201910197163.6A Division CN110187119B (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
CN201910197437.1A Division CN110187121B (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
CN201410747937.5A Division CN104777307B (zh) | 2008-10-31 | 2009-11-02 | 先兆子痫检测和治疗的方法和组合物 |
CN201410748445.8A Division CN104777308B (zh) | 2008-10-31 | 2009-11-02 | 先兆子痫检测和治疗的方法和组合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102483418A CN102483418A (zh) | 2012-05-30 |
CN102483418B true CN102483418B (zh) | 2015-01-07 |
Family
ID=42125890
Family Applications (12)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201910197163.6A Active CN110187119B (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
CN201710343422.2A Pending CN107677829A (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
CN200980153533.0A Active CN102483418B (zh) | 2008-10-31 | 2009-11-02 | 先兆子痫检测和治疗的方法和组合物 |
CN201410748445.8A Active CN104777308B (zh) | 2008-10-31 | 2009-11-02 | 先兆子痫检测和治疗的方法和组合物 |
CN201710343423.7A Pending CN107677830A (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
CN201710342959.7A Pending CN107677828A (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
CN201410747689.4A Active CN105044347B (zh) | 2008-10-31 | 2009-11-02 | 先兆子痫检测和治疗的方法和组合物 |
CN201910197424.4A Active CN110208540B (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
CN201410747937.5A Active CN104777307B (zh) | 2008-10-31 | 2009-11-02 | 先兆子痫检测和治疗的方法和组合物 |
CN201910197437.1A Active CN110187121B (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
CN201910197165.5A Active CN110187120B (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
CN201410747896.XA Active CN105021821B (zh) | 2008-10-31 | 2009-11-02 | 先兆子痫检测和治疗的方法和组合物 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
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CN201910197163.6A Active CN110187119B (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
CN201710343422.2A Pending CN107677829A (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
Family Applications After (9)
Application Number | Title | Priority Date | Filing Date |
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CN201410748445.8A Active CN104777308B (zh) | 2008-10-31 | 2009-11-02 | 先兆子痫检测和治疗的方法和组合物 |
CN201710343423.7A Pending CN107677830A (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
CN201710342959.7A Pending CN107677828A (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
CN201410747689.4A Active CN105044347B (zh) | 2008-10-31 | 2009-11-02 | 先兆子痫检测和治疗的方法和组合物 |
CN201910197424.4A Active CN110208540B (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
CN201410747937.5A Active CN104777307B (zh) | 2008-10-31 | 2009-11-02 | 先兆子痫检测和治疗的方法和组合物 |
CN201910197437.1A Active CN110187121B (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
CN201910197165.5A Active CN110187120B (zh) | 2008-10-31 | 2009-11-02 | 子痫前期检测和治疗的方法和组合物 |
CN201410747896.XA Active CN105021821B (zh) | 2008-10-31 | 2009-11-02 | 先兆子痫检测和治疗的方法和组合物 |
Country Status (4)
Country | Link |
---|---|
US (4) | US9229009B2 (zh) |
CN (12) | CN110187119B (zh) |
HK (3) | HK1250061A1 (zh) |
WO (1) | WO2010062377A2 (zh) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
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CN110187119B (zh) * | 2008-10-31 | 2022-07-29 | 耶鲁大学 | 子痫前期检测和治疗的方法和组合物 |
WO2011057029A1 (en) * | 2009-11-04 | 2011-05-12 | Novartis Ag | Positively charged species as binding reagents in the separation of protein aggregates from monomers |
WO2013053359A1 (en) | 2011-10-14 | 2013-04-18 | Aarhus Universitet | Diagnostic and prognostic use of prombp-complexes |
US9340784B2 (en) | 2012-03-19 | 2016-05-17 | Ionis Pharmaceuticals, Inc. | Methods and compositions for modulating alpha-1-antitrypsin expression |
KR101996123B1 (ko) | 2012-06-27 | 2019-07-03 | 에프. 호프만-라 로슈 아게 | 특정 시기 내에 임신중독증의 개시를 배제하기 위한 sFlt-1/PlGF 또는 엔도글린/PlGF 비의 적용 수단 및 방법 |
SG11201501065QA (en) * | 2012-09-04 | 2015-03-30 | Pluristem Ltd | Methods for prevention and treatment of preeclampsia |
EP2972344B1 (en) * | 2013-03-14 | 2019-01-16 | Immucor Gti Diagnostics, Inc. | Methods and compositions for diagnosing preeclampsia |
CN103513042A (zh) * | 2013-09-23 | 2014-01-15 | 中国科学院动物研究所 | 用于预测或早期诊断妊娠高血压疾病的试剂盒 |
CN106662589B (zh) * | 2014-03-21 | 2019-07-30 | 艾基诺米公司 | 先兆子痫的早期检测 |
JP6697394B2 (ja) * | 2014-04-10 | 2020-05-20 | イェール ユニバーシティーYale University | 異常折り畳みタンパク質を検出するための方法および組成物 |
CN105092854A (zh) * | 2014-05-07 | 2015-11-25 | 湖州数问生物技术有限公司 | 体外诊断装置和试剂盒 |
US20160025737A1 (en) | 2014-07-25 | 2016-01-28 | Diabetomics, Llc | Biomarkers for assessment of preeclampsia |
WO2016176859A1 (zh) * | 2015-05-07 | 2016-11-10 | 浙江数问生物技术有限公司 | 体外诊断装置和试剂盒 |
CA2932204A1 (en) * | 2015-06-25 | 2016-12-25 | Alaya Care Inc. | Method for predicting adverse events for home healthcare of remotely monitored patients |
DK3322985T3 (da) * | 2015-07-15 | 2022-01-17 | Gestvision Inc | Anordning til påvisning af fejlfoldede proteiner og fremgangsmåder til anvendelse deraf |
US20160324920A1 (en) * | 2016-06-24 | 2016-11-10 | Ian Gill Bemis | Cellular Specific Therapeutic Prion |
US11061019B2 (en) * | 2017-06-14 | 2021-07-13 | Jinghong Chen | High sensitivity optical detection system |
WO2019128506A1 (zh) * | 2017-12-28 | 2019-07-04 | 浙江数问生物技术有限公司 | 一种检测错误折叠蛋白质的装置、试剂盒和方法 |
CN110305954B (zh) * | 2019-07-19 | 2022-10-04 | 广州市达瑞生物技术股份有限公司 | 一种早期准确检测先兆子痫的预测模型 |
WO2021178448A1 (en) * | 2020-03-02 | 2021-09-10 | Motor Life Sciences, Llc | Compositions and methods for diagnosing, preventing, and treating amyotrophic lateral sclerosis in patients with hypofunctional anti-trypsin activity |
WO2021261451A1 (ja) * | 2020-06-24 | 2021-12-30 | 旭化成メディカル株式会社 | タンパク質含有溶液の評価方法 |
AU2021384645A1 (en) * | 2020-11-21 | 2023-07-06 | Shuwen Biotech Co., Ltd. | Apparatus and method for detecting misfolded protein in biological sample |
CN112582068B (zh) * | 2020-12-31 | 2022-09-20 | 山东省妇幼保健院 | 一种用于妊娠期子痫症状的安全装置 |
WO2024073597A1 (en) * | 2022-09-30 | 2024-04-04 | The Board Of Trustees Of The Leland Stanford Junior University | Pathology modifying neuromodulation therapy design |
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US20110280863A1 (en) | 2011-11-17 |
HK1250393A1 (zh) | 2018-12-14 |
CN104777307A (zh) | 2015-07-15 |
US20210255192A1 (en) | 2021-08-19 |
HK1250061A1 (zh) | 2018-11-23 |
CN110208540A (zh) | 2019-09-06 |
CN110187120B (zh) | 2022-07-01 |
US9229009B2 (en) | 2016-01-05 |
US20170356920A1 (en) | 2017-12-14 |
CN105021821B (zh) | 2018-05-11 |
CN107677829A (zh) | 2018-02-09 |
CN104777308B (zh) | 2017-04-12 |
CN110187119B (zh) | 2022-07-29 |
CN105021821A (zh) | 2015-11-04 |
CN110187119A (zh) | 2019-08-30 |
CN105044347A (zh) | 2015-11-11 |
CN110187120A (zh) | 2019-08-30 |
CN104777308A (zh) | 2015-07-15 |
WO2010062377A3 (en) | 2010-08-05 |
CN107677830A (zh) | 2018-02-09 |
CN110208540B (zh) | 2024-02-09 |
CN110187121B (zh) | 2022-07-01 |
US10048276B2 (en) | 2018-08-14 |
CN107677828A (zh) | 2018-02-09 |
HK1250392A1 (zh) | 2018-12-14 |
US11125758B2 (en) | 2021-09-21 |
CN104777307B (zh) | 2019-10-18 |
CN102483418A (zh) | 2012-05-30 |
CN110187121A (zh) | 2019-08-30 |
CN105044347B (zh) | 2017-06-09 |
WO2010062377A2 (en) | 2010-06-03 |
US20160097775A1 (en) | 2016-04-07 |
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