CN102478551B - 一种测定土荆芥挥发油中有效成分含量的方法 - Google Patents
一种测定土荆芥挥发油中有效成分含量的方法 Download PDFInfo
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- CN102478551B CN102478551B CN201010555963.XA CN201010555963A CN102478551B CN 102478551 B CN102478551 B CN 102478551B CN 201010555963 A CN201010555963 A CN 201010555963A CN 102478551 B CN102478551 B CN 102478551B
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- volatile oil
- reference substance
- solution
- ascaridole
- terpinene
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- 239000000341 volatile oil Substances 0.000 title claims abstract description 44
- 238000000034 method Methods 0.000 title claims abstract description 26
- 235000000509 Chenopodium ambrosioides Nutrition 0.000 title claims abstract description 18
- 241000309574 Dysphania ambrosioides Species 0.000 title claims abstract 7
- 239000007788 liquid Substances 0.000 claims abstract description 12
- YHQGMYUVUMAZJR-UHFFFAOYSA-N α-terpinene Chemical compound CC(C)C1=CC=C(C)CC1 YHQGMYUVUMAZJR-UHFFFAOYSA-N 0.000 claims description 54
- HFPZCAJZSCWRBC-UHFFFAOYSA-N p-cymene Chemical compound CC(C)C1=CC=C(C)C=C1 HFPZCAJZSCWRBC-UHFFFAOYSA-N 0.000 claims description 52
- 239000013558 reference substance Substances 0.000 claims description 31
- MGYMHQJELJYRQS-UHFFFAOYSA-N Ascaridole Chemical compound C1CC2(C)OOC1(C(C)C)C=C2 MGYMHQJELJYRQS-UHFFFAOYSA-N 0.000 claims description 27
- 241000219312 Chenopodium Species 0.000 claims description 27
- WSTYNZDAOAEEKG-UHFFFAOYSA-N Mayol Natural products CC1=C(O)C(=O)C=C2C(CCC3(C4CC(C(CC4(CCC33C)C)=O)C)C)(C)C3=CC=C21 WSTYNZDAOAEEKG-UHFFFAOYSA-N 0.000 claims description 27
- MGYMHQJELJYRQS-ZJUUUORDSA-N ascaridole Natural products C1C[C@]2(C)OO[C@@]1(C(C)C)C=C2 MGYMHQJELJYRQS-ZJUUUORDSA-N 0.000 claims description 27
- 238000012360 testing method Methods 0.000 claims description 17
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical group CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 239000012467 final product Substances 0.000 claims description 6
- 239000000470 constituent Substances 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 3
- 238000010812 external standard method Methods 0.000 claims description 2
- 239000012925 reference material Substances 0.000 claims description 2
- -1 obtain Substances 0.000 claims 1
- 244000281762 Chenopodium ambrosioides Species 0.000 description 11
- 238000003556 assay Methods 0.000 description 6
- 238000001514 detection method Methods 0.000 description 6
- PBCJIPOGFJYBJE-UHFFFAOYSA-N acetonitrile;hydrate Chemical group O.CC#N PBCJIPOGFJYBJE-UHFFFAOYSA-N 0.000 description 5
- 238000004128 high performance liquid chromatography Methods 0.000 description 5
- 239000012071 phase Substances 0.000 description 5
- 238000004587 chromatography analysis Methods 0.000 description 4
- 239000007791 liquid phase Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000000767 anti-ulcer Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000004817 gas chromatography Methods 0.000 description 2
- 229940037467 helicobacter pylori Drugs 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 241000219317 Amaranthaceae Species 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000006877 Insect Bites and Stings Diseases 0.000 description 1
- 208000004078 Snake Bites Diseases 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000003822 preparative gas chromatography Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
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- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Abstract
Description
Claims (4)
Priority Applications (1)
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CN201010555963.XA CN102478551B (zh) | 2010-11-23 | 2010-11-23 | 一种测定土荆芥挥发油中有效成分含量的方法 |
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CN201010555963.XA CN102478551B (zh) | 2010-11-23 | 2010-11-23 | 一种测定土荆芥挥发油中有效成分含量的方法 |
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CN102478551A CN102478551A (zh) | 2012-05-30 |
CN102478551B true CN102478551B (zh) | 2014-09-17 |
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CN201010555963.XA Active CN102478551B (zh) | 2010-11-23 | 2010-11-23 | 一种测定土荆芥挥发油中有效成分含量的方法 |
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Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103940916B (zh) * | 2013-01-17 | 2017-11-21 | 天士力制药集团股份有限公司 | 一种荆花胃康胶丸指纹图谱分析方法 |
CN109507305B (zh) * | 2018-08-30 | 2021-07-16 | 河北中医学院 | 一种基于HPLC、UV-Vis技术的荆芥药材质量综合检测鉴别方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1959405A (zh) * | 2005-11-04 | 2007-05-09 | 天津天士力制药股份有限公司 | 一种对伞花烃的含量测定方法 |
CN101183089A (zh) * | 2006-11-13 | 2008-05-21 | 天津天士力制药股份有限公司 | 一种对伞花烃的含量测定方法 |
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2010
- 2010-11-23 CN CN201010555963.XA patent/CN102478551B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1959405A (zh) * | 2005-11-04 | 2007-05-09 | 天津天士力制药股份有限公司 | 一种对伞花烃的含量测定方法 |
CN101183089A (zh) * | 2006-11-13 | 2008-05-21 | 天津天士力制药股份有限公司 | 一种对伞花烃的含量测定方法 |
Non-Patent Citations (8)
Title |
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Combined Analysis of the Essential Oil of Chenopodium ambrosioides by GC, GC-MS and 13C-NMR Spectroscopy: Quantitative Determination of Ascaridole, a Heat-sensitive Compound;Jean-Francois Cavalli et al.;《PHYTOCHEMICAL ANALYSIS》;20041013;第15卷(第5期);第275-279页 * |
HPLC法测定土荆芥中棚皮素和山奈素的含量;潘馨 等;《药物分析杂志》;20081231;第28卷(第9期);第1500-1502页 * |
Jean-Francois Cavalli et al..Combined Analysis of the Essential Oil of Chenopodium ambrosioides by GC, GC-MS and 13C-NMR Spectroscopy: Quantitative Determination of Ascaridole, a Heat-sensitive Compound.《PHYTOCHEMICAL ANALYSIS》.2004,第15卷(第5期), |
RP-HPLC法分离和测定荆花胃康原料药和胶丸中的对-异丙基甲苯和α-萜品烯;李意;《分析试验室》;20060630;第25卷(第6期);第25-27页 * |
土荆芥挥发油的化学成分分析;黄雪峰 等;《中国药科大学学报》;20021231;第33卷(第3期);第256-257页 * |
李意.RP-HPLC法分离和测定荆花胃康原料药和胶丸中的对-异丙基甲苯和α-萜品烯.《分析试验室》.2006,第25卷(第6期), |
潘馨 等.HPLC法测定土荆芥中棚皮素和山奈素的含量.《药物分析杂志》.2008,第28卷(第9期), |
黄雪峰 等.土荆芥挥发油的化学成分分析.《中国药科大学学报》.2002,第33卷(第3期), |
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Address after: 300410 Tianjin City Hedong District of Beichen Puji Road No. 2 city of the modern Chinese Medicine Applicant after: Tasly Pharmaceutical Group Co., Ltd. Address before: 300410 Tianjin City Hedong District of Beichen Puji Road No. 2 city of the modern Chinese Medicine Applicant before: Tianjin Tianshili Pharmaceutical Co., Ltd. |
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Address after: 300410 Tianjin city Beichen District Huaihe road and road intersection Dingjiang tianzhijiao Park forensic Center for Intellectual Property Department Patentee after: Tasly Pharmaceutical Group Limited by Share Ltd Address before: 300410 Tianjin City Hedong District of Beichen Puji Road No. 2 city of the modern Chinese Medicine Patentee before: Tasly Pharmaceutical Group Co., Ltd. |
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