CN102406958A - Preparation method of sterile honey dressing - Google Patents
Preparation method of sterile honey dressing Download PDFInfo
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- CN102406958A CN102406958A CN2011103930761A CN201110393076A CN102406958A CN 102406958 A CN102406958 A CN 102406958A CN 2011103930761 A CN2011103930761 A CN 2011103930761A CN 201110393076 A CN201110393076 A CN 201110393076A CN 102406958 A CN102406958 A CN 102406958A
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- weight
- honey
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 235000012907 honey Nutrition 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 238000002156 mixing Methods 0.000 claims abstract description 18
- 239000000463 material Substances 0.000 claims abstract description 16
- 239000000203 mixture Substances 0.000 claims abstract description 13
- 239000000835 fiber Substances 0.000 claims abstract description 11
- 238000007765 extrusion coating Methods 0.000 claims abstract description 9
- 239000004745 nonwoven fabric Substances 0.000 claims abstract description 6
- 239000000648 calcium alginate Substances 0.000 claims abstract description 5
- 235000010410 calcium alginate Nutrition 0.000 claims abstract description 5
- 229960002681 calcium alginate Drugs 0.000 claims abstract description 5
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 claims abstract description 5
- 240000003553 Leptospermum scoparium Species 0.000 claims description 29
- 235000016887 Leptospermum scoparium Nutrition 0.000 claims description 29
- 230000000844 anti-bacterial effect Effects 0.000 claims description 17
- 238000003756 stirring Methods 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 10
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims description 8
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims description 8
- 239000011248 coating agent Substances 0.000 claims description 8
- 238000000576 coating method Methods 0.000 claims description 8
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 7
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 7
- 239000004744 fabric Substances 0.000 claims description 7
- 239000011734 sodium Substances 0.000 claims description 7
- 229910052708 sodium Inorganic materials 0.000 claims description 7
- 229920001817 Agar Polymers 0.000 claims description 6
- 239000008272 agar Substances 0.000 claims description 6
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 5
- 230000000845 anti-microbial effect Effects 0.000 claims description 5
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 5
- 229940126864 fibroblast growth factor Drugs 0.000 claims description 5
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 5
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- XINQFOMFQFGGCQ-UHFFFAOYSA-L (2-dodecoxy-2-oxoethyl)-[6-[(2-dodecoxy-2-oxoethyl)-dimethylazaniumyl]hexyl]-dimethylazanium;dichloride Chemical compound [Cl-].[Cl-].CCCCCCCCCCCCOC(=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(=O)OCCCCCCCCCCCC XINQFOMFQFGGCQ-UHFFFAOYSA-L 0.000 claims description 3
- 206010052428 Wound Diseases 0.000 description 15
- 208000027418 Wounds and injury Diseases 0.000 description 15
- 230000000694 effects Effects 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 3
- 230000035876 healing Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000378515 Melaleuca bracteata Species 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000589 cicatrix Anatomy 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a preparation method of a sterile honey dressing, which comprises the following steps: 1. preparing a component A; 2. preparing a component B; 3. preparing a component C; 4. taking calcium alginate fiber nonwoven fabric or medical nonwoven fabric as a component D for later use; and 5. thoroughly and evenly mixing the component A and component B in a high-shear mixer, of which the rotation speed is 3000-3500 rpm, for 10-25 minutes into a semigel state, slowly adding the component C, mixing at a lower rotation speed of 150-200 rpm for 30-45 minutes, putting the component A/B/C mixture material aside for later use, taking 10 square meters of component D, putting the component D in a double-roller extrusion coating machine, and adding the component A/B/C mixture material into the double-roller extrusion coating machine to prepare the sterile honey dressing at 10 DEG C or below, wherein 200-350g of the component A/B/C mixture material is coated on every square meter of the component D.
Description
Technical field
The present invention relates to a kind of method for preparing of antibacterial honey dressing.
Background technology
Lack nutrient substance in present many adjuvants, cause wound can't produce metabolic function because of bacterial infection with regard to some wounds that make like this, make wound be difficult to healing.
Summary of the invention
The invention provides a kind of method for preparing of antibacterial honey dressing, it not only has stronger sterilizing ability, and can enhance metabolism, and wound can be healed very soon.
The present invention has adopted following technical scheme: a kind of method for preparing of antibacterial honey dressing, and it may further comprise the steps:
Step 1; Preparation A component: get Manuka honey 1000 grams; In Manuka honey, contain antimicrobial component UMF, the weight of UMF accounts for 6-10% of Manuka honey gross weight, in Manuka honey, adds pure water 10-25 grams and is prepared into the A component through the mixing for standby use that stirs again;
Step 2, preparation B component: the weight of getting cross-linked carboxymethyl fiber sodium is that the weight of 50-100 grams, sodium carboxymethyl cellulose is subsequent use after 100-150 grams mix, and this is the B component;
Step 3, preparation C component: getting subsequent use behind 3-8 gram fibroblast growth factors and agar 10-20 gram mix homogeneously is the C component;
Step 4, it is subsequent use to get calcium alginate fibre non-woven fabrics or medical adhesive-bonded fabric, and this is the D component;
Step 5 is blended in A component and B component in the high shear stirring machine and stirs, and its rotating speed is 3000-3500 to change; Mixing time is 10-25 minutes, makes its abundant mix homogeneously, becomes the semigel state; After slowly add the C component and stir; Mixing speed should slow down to Revolution Per Minute 150-200 changes, and mixing time is 30-45 minutes, places the mixed material of A component, B component and C component subsequent use on one side; Get 10 square metres of D components; Put into two roller extrusion coating machines, the mixed material of the A component that is equipped with, B component and C component is added in two roller extrusion coating machines be 10 degree or be coated with fabric antibacterial honey dressing below 10 degree that in temperature A component, B component and the mixed material of C component of its every square metre D component coating is 200-350 grams again.
The weight of UMF accounts for 8% of Manuka honey gross weight in the step 1 of the present invention, and the weight of in Manuka honey, adding pure water is 20 grams.The weight of cross-linked carboxymethyl fiber sodium is that the weight of 70 grams, sodium carboxymethyl cellulose is 120 grams in the step 2 of the present invention.Fibroblast growth factor is 5 grams in the step 3 of the present invention, agar 15 grams.Rotating speed when A component and B component stir in the step 5 of the present invention is 3000 commentaries on classics; The time of stirring is 15 minutes; It is that Revolution Per Minute 150 changes that adding C component mixing speed should slow down; Mixing time is 30 minutes, and A component, B component and the mixed material of C component of every square metre of D component coating is 200 grams.
The present invention has following beneficial effect: Manuka honey is that adopt the free of contamination purlieu growth in Zelanian coastal area a kind of is the flower on the black tea tree of Manuka (manuka), and by the nectar of the Apis collection of locality, this nectar is distinctive Manuka honey; Containing a kind of distinctive active antibacterial material in this Manuka honey---manuka factor UMF (Unigue.Manuka Factor), the present invention adopt a kind of Manuka antibacterial Mel and calcium alginate non-woven fabrics or the made medical dressing of medical adhesive-bonded fabric, make dressing that stronger sterilizing ability is arranged like this and provide oligosaccharide nutrition to enhance metabolism; Accelerate the healing of wound; Thereby not only can absorb a large amount of wound fluids, the enough nutrition of wound is provided, can clear up the harmful substance of wound; And the fibroblast production factor of wound is provided; Promote wound healing, provide enough can germ-resistant active substance, provide the wet environment of wound; It is not formed a scab, painstakingly reduce the formation of cicatrix.Manuka honey has unique anti-microbial property and oxidation resistance; Having more the ability of superpower destruction antibacterial, and can better treat the wound of body, is a kind of medicine of natural treatment wound; Has no side effect; Be " superfine product in the honey " in the Mel, being equipped with crosslinked cross-linked carboxymethyl fiber sodium and cross-linked carboxymethyl fiber sodium can increase processing and hygroscopic effect to wound, and being equipped with fibroblast growth factor and agar can accelerating wound; In sum, the present invention has following advantage: Manuka honey can provide enough antimicrobial components; 2, Manuka honey only needs seldom that composition just can have germ-resistant effect; 3, the antibacterial activity of Manuka honey equals the silver-colored sterilizing ability of 15000ppm.More than the operation below 10 degree Celsius of all temperature produce, in order to avoid too high and make Manuka honey generation rheological phenomena and to influence uniformity and the fibroblast growth factor Yin Wendu of coating too high and lose activity.Above manufactured goods are cut into needed specification be applied to wound.It is 10 degree or coating below 10 degree that the mixed material of A component of the present invention, B component and C component adds in two roller extrusion coating machines in temperature, like this in order to avoid too high and make Manuka honey generation rheological phenomena and to influence uniformity and the fibroblast growth factor Yin Wendu of coating too high and lose activity.
The specific embodiment
The invention discloses a kind of method for preparing of antibacterial honey dressing, it may further comprise the steps:
Step 1; Preparation A component: get Manuka honey 1000 grams; In Manuka honey, contain antimicrobial component UMF, the weight of UMF accounts for 8% of Manuka honey gross weight, in Manuka honey, adds pure water 20 grams and is prepared into the A component through the mixing for standby use that stirs again; Step 2, preparation B component: the weight of getting cross-linked carboxymethyl fiber sodium is that the weight of 70 grams, sodium carboxymethyl cellulose is subsequent use after 120 grams mix, and this is the B component; Step 3, preparation C component: getting subsequent use behind 5 gram fibroblast growth factors and the agar 15 gram mix homogeneously is the C component; Step 4, it is subsequent use to get calcium alginate fibre non-woven fabrics or medical adhesive-bonded fabric, and this is the D component; Step 5 is blended in A component and B component in the high shear stirring machine and stirs, and its rotating speed is 3000 to change; Mixing time is 10 minutes, makes its abundant mix homogeneously, becomes the semigel state; After slowly add the C component and stir; Mixing speed should slow down to Revolution Per Minute 150 changes, and mixing time is 30 minutes, places the mixed material of A component, B component and C component subsequent use on one side; Get 10 square metres of D components; Put into two roller extrusion coating machines, the mixed material of the A component that is equipped with, B component and C component is added in two roller extrusion coating machines be 10 degree or be coated with fabric antibacterial honey dressing below 10 degree that in temperature A component, B component and the mixed material of C component of its every square metre D component coating is 200 grams again.
Claims (5)
1. the method for preparing of an antibacterial honey dressing, it may further comprise the steps:
Step 1; Preparation A component: get Manuka honey 1000 grams; In Manuka honey, contain antimicrobial component UMF, the weight of UMF accounts for 6-10% of Manuka honey gross weight, in Manuka honey, adds pure water 10-25 grams and is prepared into the A component through the mixing for standby use that stirs again;
Step 2, preparation B component: the weight of getting cross-linked carboxymethyl fiber sodium is that the weight of 50-100 grams, sodium carboxymethyl cellulose is subsequent use after 100-150 grams mix, and this is the B component;
Step 3, preparation C component: getting subsequent use behind 3-8 gram fibroblast growth factors and agar 10-20 gram mix homogeneously is the C component;
Step 4, it is subsequent use to get calcium alginate fibre non-woven fabrics or medical adhesive-bonded fabric, and this is the D component;
Step 5 is blended in A component and B component in the high shear stirring machine and stirs, and its rotating speed is 3000-3500 to change; Mixing time is 10-25 minutes, makes its abundant mix homogeneously, becomes the semigel state; After slowly add the C component and stir; Mixing speed should slow down to Revolution Per Minute 150-200 changes, and mixing time is 30-45 minutes, places the mixed material of A component, B component and C component subsequent use on one side; Get 10 square metres of D components; Put into two roller extrusion coating machines, the mixed material of the A component that is equipped with, B component and C component is added in two roller extrusion coating machines be 10 degree or be coated with fabric antibacterial honey dressing below 10 degree that in temperature A component, B component and the mixed material of C component of its every square metre D component coating is 200-350 grams again.
2. the method for preparing of antibacterial honey dressing according to claim 1 is characterized in that the weight of UMF accounts for 8% of Manuka honey gross weight in the step 1, and the weight of in Manuka honey, adding pure water is 20 grams.
3. the method for preparing of antibacterial honey dressing according to claim 1, the weight that it is characterized in that cross-linked carboxymethyl fiber sodium in the step 2 are that the weight of 70 grams, sodium carboxymethyl cellulose is 120 grams.
4. the method for preparing of antibacterial honey dressing according to claim 1 is characterized in that fibroblast growth factor is 5 grams in the step 3, agar 15 grams.
5. the method for preparing of antibacterial honey dressing according to claim 1; It is characterized in that rotating speed when A component and B component stir in the step 5 is 3000 to change; The time of stirring is 15 minutes; Add C component mixing speed and should slow down to Revolution Per Minute 150 changes, mixing time is 30 minutes, and A component, B component and the mixed material of C component of every square metre of D component coating is 200 grams.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110393076.1A CN102406958B (en) | 2011-12-02 | 2011-12-02 | Preparation method of sterile honey dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110393076.1A CN102406958B (en) | 2011-12-02 | 2011-12-02 | Preparation method of sterile honey dressing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102406958A true CN102406958A (en) | 2012-04-11 |
| CN102406958B CN102406958B (en) | 2014-04-09 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110393076.1A Active CN102406958B (en) | 2011-12-02 | 2011-12-02 | Preparation method of sterile honey dressing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102406958B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103272259A (en) * | 2013-06-16 | 2013-09-04 | 褚加冕 | Preparation method of medical honey dressing |
| CN105288709A (en) * | 2015-11-05 | 2016-02-03 | 上海典范医疗科技有限公司 | Wet wound dressing and preparation method thereof |
| CN107468674A (en) * | 2017-09-18 | 2017-12-15 | 泰州市榕兴医疗用品股份有限公司 | Honey sterilization bandage and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1409636A (en) * | 1999-12-09 | 2003-04-09 | 威凯托陵科有限公司 | Use of honey in medical dressings |
| WO2003047642A1 (en) * | 2001-12-03 | 2003-06-12 | Acordis Speciality Fibres Limited | Wound dressings |
| CN1444488A (en) * | 2000-06-30 | 2003-09-24 | 菲利普·罗伊·卡斯基 | Use and improvement of honey in wound dressings |
| WO2005077402A1 (en) * | 2004-02-11 | 2005-08-25 | Virchow Biotech Private Limited | Honey based gel formulations |
| WO2007149958A2 (en) * | 2006-06-23 | 2007-12-27 | Jentec Inc. | Superthin wound dressing having folded release sheet |
| CN102083473A (en) * | 2008-06-06 | 2011-06-01 | 马卢卡医学有限公司 | Compositions comprising honey and a super-absorbent material |
-
2011
- 2011-12-02 CN CN201110393076.1A patent/CN102406958B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1409636A (en) * | 1999-12-09 | 2003-04-09 | 威凯托陵科有限公司 | Use of honey in medical dressings |
| CN1444488A (en) * | 2000-06-30 | 2003-09-24 | 菲利普·罗伊·卡斯基 | Use and improvement of honey in wound dressings |
| WO2003047642A1 (en) * | 2001-12-03 | 2003-06-12 | Acordis Speciality Fibres Limited | Wound dressings |
| WO2005077402A1 (en) * | 2004-02-11 | 2005-08-25 | Virchow Biotech Private Limited | Honey based gel formulations |
| WO2007149958A2 (en) * | 2006-06-23 | 2007-12-27 | Jentec Inc. | Superthin wound dressing having folded release sheet |
| CN102083473A (en) * | 2008-06-06 | 2011-06-01 | 马卢卡医学有限公司 | Compositions comprising honey and a super-absorbent material |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103272259A (en) * | 2013-06-16 | 2013-09-04 | 褚加冕 | Preparation method of medical honey dressing |
| CN105288709A (en) * | 2015-11-05 | 2016-02-03 | 上海典范医疗科技有限公司 | Wet wound dressing and preparation method thereof |
| CN105288709B (en) * | 2015-11-05 | 2018-05-22 | 上海典范医疗科技有限公司 | wet wound dressing and preparation method thereof |
| CN107468674A (en) * | 2017-09-18 | 2017-12-15 | 泰州市榕兴医疗用品股份有限公司 | Honey sterilization bandage and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102406958B (en) | 2014-04-09 |
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Owner name: TAIZHOU RONGXING ANTI-ADHESION DRESSING CO., LTD. Free format text: FORMER OWNER: CHU JIAMIAN Effective date: 20150327 |
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Effective date of registration: 20150327 Address after: 225300, No. 8, Far East Avenue, Taizhou high port area, Jiangsu Patentee after: Taizhou Rongxing Anti-adhesion Dressing Co., Ltd. Address before: 225321 Taizhou, Jiangsu Port Industrial Park, Far East Avenue, No. 8 Patentee before: Chu Jiamian |
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Address after: 225300, No. 8, Far East Avenue, Taizhou high port area, Jiangsu Patentee after: ROOSIN MEDICAL CO., LTD. Address before: 225300, No. 8, Far East Avenue, Taizhou high port area, Jiangsu Patentee before: Taizhou Rongxing Anti-adhesion Dressing Co., Ltd. |
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Denomination of invention: A preparation method of sterilized honey dressing Effective date of registration: 20201215 Granted publication date: 20140409 Pledgee: Bank of China Limited by Share Ltd. Taizhou Gaogang sub branch Pledgor: TAIZHOU ROOSIN MEDICAL PRODUCT Co.,Ltd. Registration number: Y2020980009396 |
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Date of cancellation: 20211228 Granted publication date: 20140409 Pledgee: Bank of China Limited by Share Ltd. Taizhou Gaogang sub branch Pledgor: TAIZHOU ROOSIN MEDICAL PRODUCT CO.,LTD. Registration number: Y2020980009396 |
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Denomination of invention: A preparation method of bactericidal honey dressing Effective date of registration: 20211229 Granted publication date: 20140409 Pledgee: Bank of China Limited by Share Ltd. Taizhou Gaogang sub branch Pledgor: TAIZHOU ROOSIN MEDICAL PRODUCT CO.,LTD. Registration number: Y2021980016869 |
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