CN105664225A - Nano-silver, chitosan and fibroin compound biological dressing and preparation method thereof - Google Patents
Nano-silver, chitosan and fibroin compound biological dressing and preparation method thereof Download PDFInfo
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- CN105664225A CN105664225A CN201610100176.3A CN201610100176A CN105664225A CN 105664225 A CN105664225 A CN 105664225A CN 201610100176 A CN201610100176 A CN 201610100176A CN 105664225 A CN105664225 A CN 105664225A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/70—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres
- D04H1/72—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged
- D04H1/728—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Abstract
The invention relates to a nano-silver, chitosan and fibroin compound biological dressing and a preparation method thereof. Natural high-polymer materials of chitosan and fibroin are dissolved by methanoic acid to prepare solutions in different concentrations; the solutions are mixed according to a certain mass ratio; then, silver ions are mixed into the chitosan/fibroin compound biological dressing through electrostatic spinning; next, ultraviolet light is used for irradiation, so that the sliver ions are reduced into nano-silver particles; finally, the prepared compound biological dressing is put into glutaraldehyde stem for sealed crosslinking. Hydrogen bonds among molecules have a strong effect, so that the fibroin and the chitosan have good miscibility; the nano-silver with a good antibiosis effect is combined, so that the nano-silver/chitosan/fibroin compound biological dressing has the advantages that good water absorption and permeability, fast hemostasis capability and analgesia are realized; the wound surface heeling is promoted; the compound biological dressing can continuously act on regenerative bacteria; durable and efficient sterilization characteristics are realized.
Description
Technical field
The invention belongs to the preparation field of biological textiles, in particular to a kind of nanometer silver, chitosan and fibroin compound bio dressing and its preparation method.
Background technology
Skin is the natural cover for defense of human body, to maintaining the stable of internal milieu and stop microorganism invasion to play an important role. If skin is subject to big area damage, then can cause many local even systemic problems, as metabolism aggravation, moisture and protein excessively scatter and disappear, immune system disorder etc., serious goes back entail dangers to life. Rebuilding or recovering skin barrier function is the ultimate aim burning trauma care, before reaching this target, the Wound dressing of an excellent property can temporarily play the part function of skin, an environment being conducive to wound healing is provided, waits surface of a wound epithelization or be transitioned into and rebuild permanent skin barrier.
Wound dressing can be divided into traditional dressing, biological dressing and synthetic dressing etc. according to its material. The most often use and be soaked with the cotton gauze of liquid, apply ointment or plaster on wound or embed in wound, play hemostasis, analgesia, anti-inflammatory, maintenance wound humidity environment, impel wound healing etc. to act on. Traditional cotton gauze liquid absorption is less, 4～5 times of own wt usually only, simultaneously the fiber of gauze coarse cannot with tissue compatible, easily cause wound cambium to damage when changing dressings, extend wound healing time. Compared with traditional weaving medical dressing, biological dressing, owing to having the features such as good degradability, biocompatibility and toxic side effect are little, has unique effect in extensive wound is treated, becomes the focus of textile science and biomedical research. At present, the materials such as the multiplex collagen of biological dressing, chitosan, Lalgine, hyaluronic acid, based on forms such as film, sponge, gels. Although at present the biological dressing of exploitation is functionally constantly perfect, but all existing defects, cannot really meet clinical needs.
There are some defects in the pure collagen dressing in collagen class dressing: collagen has certain antigenicity in physiological conditions; Collagem membrane is easily dry and cracked, it may also be useful to time application gauze dressing cover it keep the moistening of the surface of a wound; And the degradation rate of collagen is too fast, physical strength is little. Yet there are some shortcomings at present in compound collagen biological dressing, as skin can not be replaced to become permanent coverture; Except autologous skin, other all cannot eliminate its antigenicity completely; Make, preserve, transplant costly etc., thus limit their widespread use to a certain extent. In non-collagen class dressing, Lalgine dressing can be used for protection and wound repairing, treatment burn. But alginates dressing should not be used for drying or have the surface of a wound of hard scab. The ventilative aspect of the selectivity of chitosan dressing also needs to improve further, and chemical production chitosan easily pollutes, production cost height, expensive, thus limits it to a certain extent and use. The water-absorbent of fibroin dressing, toughness, mechanicalness and anti-microbial property are poor, cover so fibroin membrane is seldom used for separately the surface of a wound, but make fibroin blend film by blended to itself and some macromolecular materials, to improve its performance.
The ideal structure of wound dressing has high porosity and good barrier. So far, nano fibrous membrane shows good application potential quality in art of wound dressings. Utilize nano fibrous membrane can meet a lot of requirement as high gas permeability as wound dressing, tunica fibrosa evenly can be combined closely with wound surface can not form ponding, and wound infection and dehydration can be prevented, crust synthesis speed can be accelerated and can promote that dermal tissue is shaped, be the good material of trauma care.
Summary of the invention
For solving the problems of the technologies described above, it is an object of the invention to provide one to there is good water suction and water permeable ability, quick-acting haemostatic powder ability, analgesic activity, wound healing, act on regenerated bacteria continuously, there is nanometer silver lasting, sterilization feature efficiently, chitosan and fibroin compound bio dressing and its preparation method.
The nanometer silver of the present invention, chitosan and fibroin compound bio dressing, it is made up of chitosan and the fibroin nanofiber containing nanometer silver, the mass ratio of described chitosan and described fibroin is 1:20～1:5, and described nanometer silver is uniformly distributed in the surface of described nanofiber.
Further, the described chitosan containing nanometer silver and fibroin nanofiber diameter are distributed as 30～200nm.
Further, the diameter of described nano-Ag particles is 5～50nm.
The preparation method of the nanometer silver of the present invention, chitosan and fibroin compound bio dressing, comprises step:
(1) prepare chitosan solution: be dissolved in the formic acid that concentration is 98wt% by the chitosan that deacetylation is 80%, be stirred to and dissolve completely, obtain the chitosan solution that concentration is 1wt%～3wt%;
(2) prepare fibroin solution: be dissolved in the formic acid that concentration is 98wt% by the fibroin that purity is 100%, be stirred to and dissolve completely, obtain the fibroin solution that concentration is 15wt%～30wt%;
(3) chitosan/fibroin/silver nitrate solution is prepared: get chitosan solution and fibroin solution, it is that 1:20～1:5 mixes by chitosan and the mass ratio of fibroin, stir after evenly and add silver nitrate powder, add-on is the 0.5wt%～5wt% of chitosan and fibroin total mass in mixing solutions, continue stirring 0.5～2 hour, until Silver Nitrate dissolves completely;
(4) chitosan/fibroin/silver nitrate solution obtained is carried out electrostatic spinning, with aluminium foil or fabrics accept nano thread, form nano fibrous membrane;
(5) UV-irradiation is adopted to carry out photoreduction in 2～3 hours the nano fibrous membrane obtained;
(6) nanometer silver/chitosan/fibroin compound bio dressing of preparation in described step (5) is placed in glutaraldehyde steam and carries out sealing crosslinked 1～3 hour.
Further, in described step (4), electrostatic spinning process parameter is: voltage is 18～35KV, and reception distance is 8～22cm, and spinning speed is 0.5ml/h, and orifice internal diameter 0.5mm, spinning at room temperature carries out.
By such scheme, the present invention at least has the following advantages:
1, chitosan has biological activity and anastalsis, the synthesis of the formation of fibrinogen element, the hyperplasia of phoirocyte and collagen protein can be stoped, the Wound dressing being made up of chitosan has good biocompatibility, degradability and ventilation property, also has the protection surface of a wound for big area burn and scald, absorbs the effects such as wound exudate, anti-inflammation and sterilization, hemostasis, analgesia, promotion wound healing and skin regeneration;
2, after fibroin dressing flap coverage, effectively avoiding the surface of a wound to expose, stop microorganism invasion, avoid body fluid to run off in a large number, suppression inflammatory cell propagation and the long-pending liquid of the surface of a wound, intelligent adjustment local wound microenvironment, prevents traumatic infection;
3, presoma-the Silver Nitrate of nanometer silver is joined in chitosan/fibroin solution and makes uniform spinning solution, by electrostatic spinning, negatively charged ion is incorporated in fiber, then by UV-irradiation, the silver ion reduction in fiber is become nano-Ag particles, the nano-Ag particles diameter obtained so only several nanometers, and nano-Ag particles is dispersed in fibrefelt, simultaneously owing to nanometer silver and nanofiber are once-forming, nano-Ag particles will be attached to chitosan/fibroin composite nano fiber surface or embed in fiber, can effectively reduce coming off and agglomeration of nanometer silver like this, the nanometer silver of formation is more uniformly distributed in compound bio dressing, silver has good antibacterial and security and stability, the nano-Ag particles made with nanotechnology form has the incomparable broad-spectrum antimicrobial of traditional antiseptic-germicide, strong bactericidal, security height, the advantage such as have no drug resistance, have a wide range of applications at antibacterial field of medicaments,
4, the nanofiber diameter adopting electrostatic spinning to produce is 5～500nm, compare spinning prepared by traditional method, little 2～4 orders of magnitude of electrostatic spinning diameter, electrospun fibers surface-area is big, porosity height, be conducive to cell adhesion and propagation, ventilative, water vapour permeability is good, is that reparation and the healing of wound provides good environment;
5, due to the strong effect of intermolecular hydrogen bonding, fibroin and chitosan have good can Combination, by promoting, albumen synthesis activates inoblast to chitosan, again in conjunction with the nanometer silver of strong anti-microbial effect, nanometer silver/chitosan/fibroin compound bio dressing has good water suction and water permeable ability, quick-acting haemostatic powder ability, analgesic activity, wound healing, acts on regenerated bacteria continuously, has sterilization feature lasting, efficient.
Above-mentioned explanation is only the general introduction of technical solution of the present invention, in order to better understand the technique means of the present invention, and can be implemented according to the content of specification sheets, below with the better embodiment of the present invention and coordinate accompanying drawing to be described in detail as follows.
Accompanying drawing explanation
Fig. 1 and Fig. 2 is the scanning electron microscope (SEM) photograph of the obtained nanometer silver/chitosan/fibroin compound bio dressing of embodiment 1;
Fig. 3 is the scanning electron microscope (SEM) photograph of the obtained nanometer silver/chitosan/fibroin compound bio dressing of embodiment 2.
Embodiment
Below in conjunction with drawings and Examples, the specific embodiment of the present invention is described in further detail. Following examples are for illustration of the present invention, but are not used for limiting the scope of the invention.
Embodiment 1
Take 0.2 gram of chitosan and 1.5 grams of fibroins are dissolved in the formic acid solution that 10 ml concns are 98wt% respectively, it is stirred to chitosan under normal temperature after sealing and fibroin dissolves all completely. Stir evenly after getting 5 grams of chitosan solutions and 10 grams of fibroin solution mixing, then 0.03 gram of silver nitrate powder is added, continue after sealing to stir 0.5 hour, light yellow clear liquid is formed after Silver Nitrate dissolves completely, leave standstill and carry out electrostatic spinning after 30 minutes, voltage is 30kV, syringe pump fltting speed is 0.4ml/h, employing aluminium foil receives, receiving distance is 15 centimetres, orifice internal diameter 0.5mm, spinning at room temperature carries out, and obtains electrostatic and spins nanometer silver/chitosan/fibroin compound bio dressing and carry out sealing in glutaraldehyde steam crosslinked 2 hours. As depicted in figs. 1 and 2, wherein average fibre diameter is 125nm to finished product electron scanning micrograph, and the median size of Argent grain is 13nm.
Embodiment 2
Take 0.2 gram of chitosan and 1.5 grams of fibroins are dissolved in the formic acid solution that 10 ml concns are 98wt% respectively, it is stirred to chitosan under normal temperature after sealing and fibroin dissolves all completely. Stir evenly after getting 5 grams of chitosan solutions and 10 grams of fibroin solution mixing, then 0.06 gram of silver nitrate powder is added, continue after sealing to stir 0.5 hour, light yellow clear liquid is formed after Silver Nitrate dissolves completely, leave standstill and carry out electrostatic spinning after 30 minutes, voltage is 30kV, syringe pump fltting speed is 0.4ml/h, employing aluminium foil receives, receiving distance is 15 centimetres, orifice internal diameter 0.5mm, spinning at room temperature carries out, and obtains electrostatic and spins nanometer silver/chitosan/fibroin compound bio dressing and carry out sealing in glutaraldehyde steam crosslinked 3 hours. As shown in Figure 3, wherein average fibre diameter is 101nm to finished product electron scanning micrograph, and the median size of Argent grain is 32nm.
Nanometer silver/the chitosan of the present invention/fibroin compound bio dressing is taking natural macromolecular material chitosan and fibroin mixture as base material, by electrostatic spinning, silver ions is incorporated in chitosan/fibroin compound bio dressing, then silver ion reduction is made to become nano-Ag particles by UV-irradiation, it is to increase the anti-microbial property of compound bio dressing.
The above is only the preferred embodiment of the present invention; it is not limited to the present invention; should be understood that; for those skilled in the art; under the prerequisite not departing from the technology of the present invention principle; can also making some improvement and modification, these improve and modification also should be considered as protection scope of the present invention.
Claims (5)
1. a nanometer silver, chitosan and fibroin compound bio dressing, it is characterized in that: be made up of chitosan and the fibroin nanofiber containing nanometer silver, the mass ratio of described chitosan and described fibroin is 1:20～1:5, and described nanometer silver is uniformly distributed in the surface of described nanofiber.
2. nanometer silver according to claim 1, chitosan and fibroin compound bio dressing, it is characterised in that: the described chitosan containing nanometer silver and fibroin nanofiber diameter are distributed as 30～200nm.
3. nanometer silver according to claim 1, chitosan and fibroin compound bio dressing, it is characterised in that: the diameter of described nano-Ag particles is 5～50nm.
4. the preparation method of a nanometer silver, chitosan and fibroin compound bio dressing, it is characterised in that comprise step:
(1) prepare chitosan solution: be dissolved in the formic acid that concentration is 98wt% by the chitosan that deacetylation is 80%, be stirred to and dissolve completely, obtain the chitosan solution that concentration is 1wt%～3wt%;
(2) prepare fibroin solution: be dissolved in the formic acid that concentration is 98wt% by the fibroin that purity is 100%, be stirred to and dissolve completely, obtain the fibroin solution that concentration is 15wt%～30wt%;
(3) chitosan/fibroin/silver nitrate solution is prepared: get chitosan solution and fibroin solution, it is that 1:20～1:5 mixes by chitosan and the mass ratio of fibroin, stir after evenly and add silver nitrate powder, add-on is the 0.5wt%～5wt% of chitosan and fibroin total mass in mixing solutions, continue stirring 0.5～2 hour, until Silver Nitrate dissolves completely;
(4) chitosan/fibroin/silver nitrate solution obtained is carried out electrostatic spinning, with aluminium foil or fabrics accept nano thread, form nano fibrous membrane;
(5) UV-irradiation is adopted to carry out photoreduction in 2～3 hours the nano fibrous membrane obtained;
(6) nanometer silver/chitosan/fibroin compound bio dressing of preparation in described step (5) is placed in glutaraldehyde steam and carries out sealing crosslinked 1～3 hour.
5. the preparation method of nanometer silver according to claim 4, chitosan and fibroin compound bio dressing, it is characterized in that: in described step (4), electrostatic spinning process parameter is: voltage is 18～35KV, reception distance is 8～22cm, spinning speed is 0.5ml/h, orifice internal diameter 0.5mm, spinning at room temperature carries out.
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| CN201610100176.3A CN105664225A (en) | 2016-02-24 | 2016-02-24 | Nano-silver, chitosan and fibroin compound biological dressing and preparation method thereof |
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Cited By (11)
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| CN106009067A (en) * | 2016-06-28 | 2016-10-12 | 宁波国际材料基因工程研究院有限公司 | Nano-silver antibacterial material and preparation method for same |
| CN106480603A (en) * | 2016-09-21 | 2017-03-08 | 东莞市联洲知识产权运营管理有限公司 | A kind of silkworm silk/bamboo former non-woven fabrics crosslinked based on oligochitosan and preparation method thereof |
| CN107400163A (en) * | 2017-07-17 | 2017-11-28 | 江南大学 | A kind of method by illumination synthetic proteins silver nanoparticle heterodimer |
| WO2017219334A1 (en) * | 2016-06-23 | 2017-12-28 | 彭鹏 | Dressing |
| CN107802527A (en) * | 2017-12-12 | 2018-03-16 | 中国药科大学 | Muffin prepared using edible mushroom source combine dressing and preparation method thereof |
| CN108221082A (en) * | 2016-12-21 | 2018-06-29 | 国立大学法人信州大学 | Nanofiber, the preparation method of nanofiber and facial mask |
| CN108714238A (en) * | 2018-06-16 | 2018-10-30 | 东莞市联洲知识产权运营管理有限公司 | A kind of porous based composite dressing for medical use of fibroin/titanium and preparation method thereof of load Anti-radiation Microbes |
| CN109825955A (en) * | 2019-02-03 | 2019-05-31 | 南通纺织丝绸产业技术研究院 | A kind of hypo-allergenic adult paper diaper of antibacterial and preparation method thereof |
| CN112006978A (en) * | 2020-09-09 | 2020-12-01 | 大连民族大学 | Targeted chitosan nano-silver gel and preparation method and application thereof |
| CN113354839A (en) * | 2020-08-26 | 2021-09-07 | 兰州大学 | Collagen-silver nanoparticle composite gel, preparation method and application |
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Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2017219334A1 (en) * | 2016-06-23 | 2017-12-28 | 彭鹏 | Dressing |
| CN106009067A (en) * | 2016-06-28 | 2016-10-12 | 宁波国际材料基因工程研究院有限公司 | Nano-silver antibacterial material and preparation method for same |
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| CN106480603B (en) * | 2016-09-21 | 2019-05-31 | 徐州云颐无纺布制品有限公司 | A kind of silk/bamboo original non-woven fabrics preparation method based on chitosan oligosaccharide crosslinking |
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| CN107400163A (en) * | 2017-07-17 | 2017-11-28 | 江南大学 | A kind of method by illumination synthetic proteins silver nanoparticle heterodimer |
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