CN102370949A - Chinese medicinal compound preparation for treating cholecystitis and preparation method thereof - Google Patents
Chinese medicinal compound preparation for treating cholecystitis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a compound Chinese medicinal preparation for cholecystitis. The compound Chinese medicinal preparation comprises the following Chinese medicinal raw materials by weight: 5-7 grams of Chinese thorowax root, 13-17 grams of baikal skullcap root, 8-12 grams of rhubarb, 8-12 grams of virgate wormwood herb, 16-24 grams of longhairy antenoron herb, 8-12 grams of turmeric root-tuber, 8-12 grams of chicken gizzard membrane, 5-7 grams of immature bitter orange, 8-12 grams of pinellia tuber, 8-12 grams of white paeony root and 5-7 grams of liquoric root. A preparation method of the compound Chinese medicinal preparation comprises the following steps of: cleaning the eleven types of medicinal materials; mixing proportionally; adding water in an amount which is 5-7 times the total weight of the medicinal materials or 70 percent by volume of ethanol for decocting for three times, every time for 50 minutes; combining decoction solutions obtained in the three times; filtering; and concentrating to obtain a liquid extract of which the specific weight is 1.17 at 60 DEG C. The compound Chinese medicinal preparation can be prepared into any pharmaceutical dosage form, such as tablets, capsules, granules, oral liquid, pills and syrup by adopting the conventional preparation process. The compound Chinese medicinal preparation has a better curative effect than the conventional medicaments for treating cholecystitis, is free from untoward reactions, and can be used for achieving a good effect on treating the cholecystitis disease.
Description
Technical field
The present invention relates to a kind of compound Chinese medicinal preparation of treating cholecystitis and preparation method thereof, belong to field of traditional Chinese.
Background technology
Cholecystitis is meant the active chronic inflammation reaction of gallbladder wall.Whether can be divided into calcareous cholecystitis and non-calcareous cholecystitis according to cholecystitis, suddenly relax the course of disease through being divided into acute cholecystitis and chronic cholecystitis again by morbidity with cholelithiasis.In recent years, because the change and the B ultrasonic broad application of dietary structure, the sickness rate of primary disease has the trend that rises year by year.
The most unsatisfactory curative effect of drug treatment of cholecystitis has some untoward reaction and toxic and side effects through clinical observation at present.
Summary of the invention
The object of the present invention is to provide a kind of Chinese traditional compound medicine of treating cholecystitis and preparation method thereof.
The present invention provides the compound Chinese medicinal preparation of a kind of Radix Bupleuri, Radix Scutellariae, Radix Et Rhizoma Rhei, Herba Artemisiae Scopariae, Herba Lysimachiae, Radix Curcumae, Endothelium Corneum Gigeriae Galli, Fructus Aurantii Immaturus, the Rhizoma Pinelliae, the Radix Paeoniae Alba, Radix Glycyrrhizae compatibility to be used to treat cholecystitis, and is effective in cure good, the advantage that has no adverse reaction.
Technical scheme of the present invention is following:
A kind of Chinese traditional compound medicine of treating cholecystitis comprises the following weight Chinese medicinal raw materials: Radix Bupleuri 5-7, Radix Scutellariae 13-17, Radix Et Rhizoma Rhei 8-12, Herba Artemisiae Scopariae 8-12, Herba Lysimachiae 16-24, Radix Curcumae 8-12, Endothelium Corneum Gigeriae Galli 8-12, Fructus Aurantii Immaturus 5-7, Rhizoma Pinelliae 8-12, Radix Paeoniae Alba 8-12, Radix Glycyrrhizae 5-7.
Wherein method for preparing is that above-mentioned 11 flavor medical materials are cleaned, and proportional mixing, the 5-7 that adds medical material gross weight water or volume ratio doubly is that 70% ethanol decocts 3 times; Each 50 minutes, merge 3 times decoction liquor, filter; And concentrate, proportion is 1.17 fluid extract when obtaining 60 ℃, adopts conventional preparation technology; Chinese medicine preparation of the present invention can be made into said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
Herba Lysimachiae heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, diuresis and expelling stone in the prescription of the present invention; The Herba Artemisiae Scopariae clearing away heat-damp and promoting diuresis has remarkable choleretic effect; Radix Bupleuri, the Radix Paeoniae Alba have inhibitory action to the chronic inflammatory disease of gallbladder; Radix Curcumae can make bile acid output increase in the bile; Radix Et Rhizoma Rhei can promote gallbladder to shrink; Radix Scutellariae has inhibitory action to chronic inflammatory disease; The Radix Glycyrrhizae heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.The several kinds of Chinese medicinal materials combined effect, the Chinese traditional compound medicine curative effect that the present invention is made is good, has no adverse reaction.
Specific embodiment
Embodiment 1:
A kind of Chinese traditional compound medicine of treating cholecystitis comprises the following weight Chinese medicinal raw materials: Radix Bupleuri 5, Radix Scutellariae 13, Radix Et Rhizoma Rhei 8, Herba Artemisiae Scopariae 8, Herba Lysimachiae 16, Radix Curcumae 8, Endothelium Corneum Gigeriae Galli 8, Fructus Aurantii Immaturus 5, the Rhizoma Pinelliae 8, the Radix Paeoniae Alba 8, Radix Glycyrrhizae 5.
Wherein method for preparing is that above-mentioned 11 flavor medical materials are cleaned, proportional mixing, and 5 times the decocting that adds the medical material gross weight boils 3 times, and each 50 minutes, merge 3 times decoction liquor, to filter, and concentrate, proportion is 1.17 fluid extract when obtaining 60 ℃.
Embodiment 2:
A kind of Chinese traditional compound medicine of treating cholecystitis comprises the following weight Chinese medicinal raw materials: Radix Bupleuri 6, Radix Scutellariae 15, Radix Et Rhizoma Rhei 10, Herba Artemisiae Scopariae 10, Herba Lysimachiae 20, Radix Curcumae 10, Endothelium Corneum Gigeriae Galli 10, Fructus Aurantii Immaturus 6, the Rhizoma Pinelliae 10, the Radix Paeoniae Alba 10, Radix Glycyrrhizae 6.
All the other are with embodiment 1.
Embodiment 3:
A kind of Chinese traditional compound medicine of treating cholecystitis comprises the following weight Chinese medicinal raw materials: Radix Bupleuri 7, Radix Scutellariae 17, Radix Et Rhizoma Rhei 12, Herba Artemisiae Scopariae 12, Herba Lysimachiae 24, Radix Curcumae 12, Endothelium Corneum Gigeriae Galli 12, Fructus Aurantii Immaturus 7, the Rhizoma Pinelliae 12, the Radix Paeoniae Alba 12, Radix Glycyrrhizae 7.
Wherein method for preparing is that above-mentioned 11 flavor medical materials are cleaned, proportional mixing, and 5 times of volume ratios that add the medical material gross weight are that 70% ethanol decocts 3 times, each 50 minutes, merges 3 times decoction liquor, filter, and concentrated, proportion is 1.17 fluid extract when obtaining 60 ℃.
Embodiment 4:
A kind of Chinese traditional compound medicine of treating cholecystitis comprises the following weight Chinese medicinal raw materials: Radix Bupleuri 5, Radix Scutellariae 13, Radix Et Rhizoma Rhei 8, Herba Artemisiae Scopariae 8, Herba Lysimachiae 16, Radix Curcumae 8, Endothelium Corneum Gigeriae Galli 8, Fructus Aurantii Immaturus 5, the Rhizoma Pinelliae 8, the Radix Paeoniae Alba 8, Radix Glycyrrhizae 5.
Wherein method for preparing is that above-mentioned 11 flavor medical materials are cleaned, proportional mixing, and 6 times of volume ratios that add the medical material gross weight are that 70% ethanol decocts 3 times, each 50 minutes, merges 3 times decoction liquor, filter, and concentrated, proportion is 1.17 fluid extract when obtaining 60 ℃.
Embodiment 5:
A kind of Chinese traditional compound medicine of treating cholecystitis comprises the following weight Chinese medicinal raw materials: Radix Bupleuri 6, Radix Scutellariae 15, Radix Et Rhizoma Rhei 10, Herba Artemisiae Scopariae 10, Herba Lysimachiae 20, Radix Curcumae 10, Endothelium Corneum Gigeriae Galli 10, Fructus Aurantii Immaturus 6, the Rhizoma Pinelliae 10, the Radix Paeoniae Alba 10, Radix Glycyrrhizae 6.
Wherein method for preparing is that above-mentioned 11 flavor medical materials are cleaned, proportional mixing, and 6 times the decocting that adds the medical material gross weight boils 3 times, and each 50 minutes, merge 3 times decoction liquor, to filter, and concentrate, proportion is 1.17 fluid extract when obtaining 60 ℃.
Embodiment 6:
A kind of Chinese traditional compound medicine of treating cholecystitis comprises the following weight Chinese medicinal raw materials: Radix Bupleuri 7, Radix Scutellariae 17, Radix Et Rhizoma Rhei 12, Herba Artemisiae Scopariae 12, Herba Lysimachiae 24, Radix Curcumae 12, Endothelium Corneum Gigeriae Galli 12, Fructus Aurantii Immaturus 7, the Rhizoma Pinelliae 12, the Radix Paeoniae Alba 12, Radix Glycyrrhizae 7.
Wherein method for preparing is that above-mentioned 11 flavor medical materials are cleaned, proportional mixing, and 6 times the decocting that adds the medical material gross weight boils 3 times, and each 50 minutes, merge 3 times decoction liquor, to filter, and concentrate, proportion is 1.17 fluid extract when obtaining 60 ℃.
Embodiment 7:
A kind of Chinese traditional compound medicine of treating cholecystitis comprises the following weight Chinese medicinal raw materials: Radix Bupleuri 6, Radix Scutellariae 15, Radix Et Rhizoma Rhei 10, Herba Artemisiae Scopariae 10, Herba Lysimachiae 20, Radix Curcumae 10, Endothelium Corneum Gigeriae Galli 10, Fructus Aurantii Immaturus 6, the Rhizoma Pinelliae 10, the Radix Paeoniae Alba 10, Radix Glycyrrhizae 6.
Wherein method for preparing is that above-mentioned 11 flavor medical materials are cleaned, proportional mixing, and 7 times of volume ratios that add the medical material gross weight are that 70% ethanol decocts 3 times, each 50 minutes, merges 3 times decoction liquor, filter, and concentrated, proportion is 1.17 fluid extract when obtaining 60 ℃.
Embodiment 8:
A kind of Chinese traditional compound medicine of treating cholecystitis comprises the following weight Chinese medicinal raw materials: Radix Bupleuri 3, Radix Scutellariae 10, Radix Et Rhizoma Rhei 5, Herba Artemisiae Scopariae 5, Herba Lysimachiae 15, Radix Curcumae 15, Endothelium Corneum Gigeriae Galli 15, Fructus Aurantii Immaturus 10, the Rhizoma Pinelliae 13, the Radix Paeoniae Alba 15, Radix Glycyrrhizae 10.
Wherein method for preparing is that above-mentioned 11 flavor medical materials are cleaned, proportional mixing, and 7 times the decocting that adds the medical material gross weight boils 3 times, and each 50 minutes, merge 3 times decoction liquor, to filter, and concentrate, proportion is 1.17 fluid extract when obtaining 60 ℃.
Embodiment 9:
A kind of Chinese traditional compound medicine of treating cholecystitis comprises the following weight Chinese medicinal raw materials: Radix Bupleuri 10, Radix Scutellariae 20, Radix Et Rhizoma Rhei 15, Herba Artemisiae Scopariae 15, Herba Lysimachiae 25, Radix Curcumae 6, Endothelium Corneum Gigeriae Galli 5, Fructus Aurantii Immaturus 2, the Rhizoma Pinelliae 5, the Radix Paeoniae Alba 6, Radix Glycyrrhizae 3.
Wherein method for preparing is that above-mentioned 11 flavor medical materials are cleaned, proportional mixing, and 7 times of volume ratios that add the medical material gross weight are that 70% ethanol decocts 3 times, each 50 minutes, merges 3 times decoction liquor, filter, and concentrated, proportion is 1.17 fluid extract when obtaining 60 ℃.
Embodiment 10:
A kind of Chinese traditional compound medicine of treating cholecystitis comprises the following weight Chinese medicinal raw materials: Radix Bupleuri 4, Radix Scutellariae 18, Radix Et Rhizoma Rhei 7, Herba Artemisiae Scopariae 13, Herba Lysimachiae 15, Radix Curcumae 12, Endothelium Corneum Gigeriae Galli 7, Fructus Aurantii Immaturus 8, the Rhizoma Pinelliae 7, the Radix Paeoniae Alba 13, Radix Glycyrrhizae 4.
Wherein method for preparing is that above-mentioned 11 flavor medical materials are cleaned, proportional mixing, and 4 times the decocting that adds the medical material gross weight boils 3 times, and each 50 minutes, merge 3 times decoction liquor, to filter, and concentrate, proportion is 1.17 fluid extract when obtaining 60 ℃.
Embodiment 11:
" chronic cholecystitis Chinese medicine therapy 56 routine observation of curative effect " disclosed white plan Chinese medicine according in " the Chinese Chinese medicine consultancy " 2011,03 (2) gives depressed liver-energy dispersing and function of gallbladder promoting soup, comprises the following weight Chinese medicinal raw materials: Radix Bupleuri 15 g. Radix Curcumae l0g. Radix Paeoniae Alba 15 g, Herba Lysimachiae 30 g; Legendary bird with poisonous feathers GUCAO 15 g, Rhizoma Polygoni Cuspidati 15 g, Poria 10 g, Radix Scutellariae l0g; Radix Et Rhizoma Rhei (back is down) 10 g, Rhizoma Corydalis 15 g, Fructus Toosendan l0g; Rhizoma Pinelliae Preparatum 12 g, the old 30g of Rui, Endothelium Corneum Gigeriae Galli 15g. Radix Glycyrrhizae Preparata l0g.Indigestion and loss of appetite Fructus Crataegi, Massa Medicata Fermentata, the Fructus Hordei Germinatus of adding; Abdominal distention adds Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Fructus Amomi Rotundus; The side of body expands and adds Fructus Foeniculi; The insufficiency of the spleen Rhizoma Atractylodis Macrocephalae, the Pericarpium Citri Reticulatae of adding; Nauseating, vomiting adds Caulis Bambusae In Taenia.With being decocted in water for oral dose, potion on the one is taken at twice.
Embodiment 12:
According to the disclosed a kind of Chinese medicine 'lidandishi ' of treating liver and bile stone and cholecystitis of the patent of application number 02103680.2, comprise the raw material of Chinese medicine of following weight: Herba Lysimachiae 60g, Herba Artemisiae Scopariae 60g, Radix Bupleuri 25g, Fructus Forsythiae 20g, Radix Curcumae 20g, Rhizoma Curcumae Longae 20g, Rhizoma Cyperi 2g, Fructus Aurantii Immaturus 20g, Radix Scutellariae 20g, Radix Aucklandiae 20g, Radix Et Rhizoma Rhei 10g, Pericarpium Citri Reticulatae Viride 10g, Pericarpium Citri Reticulatae 10g.With the said medicine oven dry, be ground into powder, with being decocted in water for oral dose potion on the one.
Embodiment 13: adopt conventional preparation technology, Chinese medicine preparation of the present invention can be made into said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
All the other are with embodiment 1-10.
Embodiment 14: the fluid extract of the mix homogeneously that will be made by embodiment 1-10 concentrates, and according to the operational approach of conventional tablet, adds pharmaceutic adjuvant; With each component mix homogeneously, wet granulation sieves; Adopt conventional tablet preparation method tabletting to process tablet, wherein each components contents is following:
Composition weight (part)
Mixed flow extractum 50
Starch 18
Microcrystalline Cellulose 16
Pulvis Talci 15
Polyethylene Glycol 10
All the other are with embodiment 1-10.
Embodiment 15: the fluid extract of the mix homogeneously that will be made by embodiment 1-10 concentrates, and according to the operational approach of conventional capsule, adds pharmaceutic adjuvant; With each component mix homogeneously; Granulate, adopt conventional capsule preparation method to fill and process capsule, wherein each components contents is following:
Composition weight (part)
Mixed flow extractum 100
Pregelatinized Starch 32
Lactis Anhydrous 20
Microcrystalline Cellulose 18
Calcium hydrogen phosphate 8
All the other are with embodiment 1-10.
Embodiment 16: the fluid extract of the mix homogeneously that will be made by embodiment 1-10 concentrates, according to the operational approach of conventional oral liquid, ethanol precipitation 1-2 time; Filter, concentrate aqueous precipitation; Filter, add pharmaceutic adjuvant, filter; The packing sterilization adopts conventional oral liquid preparation method to prepare oral liquid, and wherein each components contents is following:
Composition weight (part)
Mixed flow extractum 100
Ethanol 155
Sucrose 85
Sodium carboxymethyl cellulose 10
Oleum menthae 5
Sorbic acid 2
All the other are with embodiment 1-10.
The effectiveness study experiment:
Patient's data: 247 routine cholecystitis patients, wherein male 119 examples, women 128 examples, age 25-68 year, average 42 years old; The course of disease is the shortest 2 months, and is the longest 25 years, average 10.2 years.247 routine patients are divided into 13 groups at random, every group 19 example, wherein 1 group as matched group, organizes as treatment for other 12 groups.
Criterion of therapeutical effect: clinical cure: clinical symptoms, sign disappear, and body temperature, hemogram recover normal.B ultrasonic shows that the gallbladder size is normal, and the edge is smooth, and entrant sound is good, follows up a case by regular visits to not recurrence in 1 year; Produce effects: clinical symptoms, sign disappear, and body temperature, hemogram are normal basically, and B ultrasonic shows that the gallbladder size is normal, and the edge is crude, and entrant sound is good, follows up a case by regular visits in 1 year to recur at least once; Invalid: clinical symptoms, sign and body temperature, hemogram, B ultrasonic gallbladder image are not seen improvement.
Therapeutic Method:
The treatment group: the Chinese medical concrete that embodiment 1-10 is made water respectively dilutes 9 times by volume, takes everyone each oral 100ml, twice of every day for respectively 10 groups of treatment groups; The medicine that oral embodiment 11 and embodiment 12 make is organized in remaining two groups of treatments.
Matched group: everyone oral XIAOYAN LIDAN PIAN, each 6, every day 3 times.
The course of treatment: treatment group and matched group all are 60 days.
Table 1 therapeutic outcome relatively
Untoward reaction: gallbladder appears in matched group ultrasound diagnosis 2 examples to be shunk, and the treatment group has no adverse reaction.
Can find out from therapeutic effect; Curative effect of the present invention is higher than the medicine of existing treatment cholecystitis; And the curative effect that is superior to the Chinese medicine medicine that similar prescription makes in the prior art; Wherein embodiment 5 best results do not have any untoward reaction again, so the present invention can obtain excellent results on the treatment cholecystitis.
Claims (5)
1. a Chinese traditional compound medicine of treating cholecystitis comprises the following weight Chinese medicinal raw materials: Radix Bupleuri 5-7, Radix Scutellariae 13-17, Radix Et Rhizoma Rhei 8-12.
2. a Chinese traditional compound medicine of treating cholecystitis comprises the following weight Chinese medicinal raw materials: Radix Bupleuri 5-7, Radix Scutellariae 13-17, Radix Et Rhizoma Rhei 8-12, Herba Artemisiae Scopariae 8-12, Herba Lysimachiae 16-24, Radix Curcumae 8-12, Endothelium Corneum Gigeriae Galli 8-12, Fructus Aurantii Immaturus 5-7, Rhizoma Pinelliae 8-12, Radix Paeoniae Alba 8-12, Radix Glycyrrhizae 5-7.
3. a Chinese traditional compound medicine of treating cholecystitis comprises the following weight Chinese medicinal raw materials: Radix Bupleuri 6, Radix Scutellariae 15, Radix Et Rhizoma Rhei 10, Herba Artemisiae Scopariae 10, Herba Lysimachiae 20, Radix Curcumae 10, Endothelium Corneum Gigeriae Galli 10, Fructus Aurantii Immaturus 6, the Rhizoma Pinelliae 10, the Radix Paeoniae Alba 10, Radix Glycyrrhizae 6.
4. like claim 2 or 3 said a kind of method for preparinies of treating the Chinese traditional compound medicine of cholecystitis, it is characterized by: 11 flavor medical materials are cleaned proportional mixing; The 5-7 that adds medical material gross weight water or volume ratio doubly is that 70% ethanol decocts 3 times, each 50 minutes, merges 3 times decoction liquor; Filter; And concentrate, proportion is 1.17 fluid extract when obtaining 60 ℃, adopts conventional preparation technology; The present invention can be made into said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
5. a kind of method for preparing of treating the Chinese traditional compound medicine of cholecystitis as claimed in claim 4 is characterized by: 11 flavor medical materials are cleaned proportional mixing; 6 times the decocting that adds the medical material gross weight boils 3 times, each 50 minutes, merges 3 times decoction liquor; Filter, and concentrate, proportion is 1.17 fluid extract when obtaining 60 ℃; Adopt conventional preparation technology, the present invention can be made into said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
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Cited By (14)
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CN102579730A (en) * | 2012-03-22 | 2012-07-18 | 吉林紫鑫药业股份有限公司 | Medicine composition for treating acute or chronic cholecystitis and acute or chronic pancreatitis |
CN102872270A (en) * | 2012-09-25 | 2013-01-16 | 朱风文 | Traditional Chinese medicine for treating chronic cholecystitis |
CN103100060A (en) * | 2013-02-18 | 2013-05-15 | 李承平 | A group of Scutellaria baicalensis and Gentian tablets used for eliminating fire |
CN103405726A (en) * | 2013-08-28 | 2013-11-27 | 李新民 | Formula of great soup for soothing liver, dispelling depression, detoxifying and nourishing spirit |
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WO2022253268A1 (en) * | 2021-06-04 | 2022-12-08 | 河北以岭医药研究院有限公司 | Traditional chinese medicine composition for treating cholecystitis and preparation method therefor |
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CN103100060A (en) * | 2013-02-18 | 2013-05-15 | 李承平 | A group of Scutellaria baicalensis and Gentian tablets used for eliminating fire |
CN103405726A (en) * | 2013-08-28 | 2013-11-27 | 李新民 | Formula of great soup for soothing liver, dispelling depression, detoxifying and nourishing spirit |
CN103495123A (en) * | 2013-10-16 | 2014-01-08 | 刘运波 | Traditional Chinese medicine for treating chronic cholecystitis |
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CN104922609A (en) * | 2015-07-17 | 2015-09-23 | 孙根火 | Medicinal preparation for treating cholecystitis |
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CN106362118A (en) * | 2016-10-25 | 2017-02-01 | 张中彦 | Traditional Chinese medicine preparation for treating acute and chronic cholecystitis |
CN107625827A (en) * | 2017-09-19 | 2018-01-26 | 江苏七0七天然制药有限公司 | A kind of Lidan Capsule and preparation method thereof |
CN107929459A (en) * | 2017-11-29 | 2018-04-20 | 罗田县人民医院 | A kind of Chinese medicine composition for treating chronic cholecystitis and preparation method thereof |
CN108186811A (en) * | 2018-02-06 | 2018-06-22 | 雷加发 | Treat the drug of cholecystitis |
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WO2022253268A1 (en) * | 2021-06-04 | 2022-12-08 | 河北以岭医药研究院有限公司 | Traditional chinese medicine composition for treating cholecystitis and preparation method therefor |
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Application publication date: 20120314 |