CN102370948A - Chinese medicinal compound preparation for treating hyperplasia of mammary glands and preparation method thereof - Google Patents
Chinese medicinal compound preparation for treating hyperplasia of mammary glands and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a compound Chinese medicinal preparation for hyperplasia of mammary glands. The compound Chinese medicinal preparation comprises the following Chinese medicinal raw materials by weight: 8-12 grams of Chinese thorowax root, 8-12 grams of white paeony root, 8-12 grams of Chinese angelica, 8-12 grams of indian buead, 13-17 grams of nutgrass galingale rhizome, 8-12 grams of turmeric root-tuber, 13-17 grams of red-rooted salvia root, 8-12 grams of common selfheal fruit-spike and 5-7 grams of cassia twig. A preparation method of the compound Chinese medicinal preparation comprises the following steps of: cleaning the nine types of medicinal materials; mixing proportionally; adding water in an amount which is 5-7 times the total weight of the medicinal materials or 75 percent by volume of ethanol for decocting twice, every time for 70 minutes; combining decoction solutions obtained in the two times; filtering; and concentrating to obtain a liquid extract of which the specific weight is 1.16 at 60 DEG C. The compound Chinese medicinal preparation can be prepared into any pharmaceutical dosage form, such as tablets, capsules, granules, oral liquid, pills and syrup by adopting the conventional preparation process. The compound Chinese medicinal preparation for treating hyperplasia of mammary glands prepared with the method has a remarkable curative effect and low reoccurrence rate, is free from untoward reactions, and shows the advantages of traditional Chinese medicines on treating hyperplasia of mammary glands.
Description
Technical field
The present invention relates to a kind of compound Chinese medicinal preparation of treating cyclomastopathy and preparation method thereof, belong to field of traditional Chinese.
Background technology
(Hyperplastic disease of breast HDB) is breast duct and lobule degeneration structurally and the variation of carrying out property to cyclomastopathy.World Health Organization's general designation " optimum mammary dysplasia "; Think that this disease mainly is because due to the hormonal system imbalance; Show as Progesterone, progestogen hyposecretion in the body; Estrogen (particularly estradiol) increases relatively, causes estrogen long-time stimulus mammary gland tissue and the proliferative lesion that takes place.
Hormone therapy cyclomastopathy condition of disease reaches the purpose that eases the pain, dwindles lump, but untoward reaction is arranged, and a lot of patients are difficult to adhere to medication, and the risk of bringing out carcinoma of endometrium is taken in very easily recurrence for a long time after the drug withdrawal.Treatment by Chinese herbs can obviously improve symptom, eliminates lump, eliminates the cause of disease from integral body, and effective, relapse rate is low, and does not have any untoward reaction, has shown the advantage of Chinese medicine cyclomastopathy.
Summary of the invention
The object of the present invention is to provide a kind of Chinese traditional compound medicine of treating cyclomastopathy and preparation method thereof.
The present invention provides the compound Chinese medicinal preparation of a kind of Radix Bupleuri, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Poria, Rhizoma Cyperi, Radix Curcumae, Radix Salviae Miltiorrhizae, Spica Prunellae, Ramulus Cinnamomi compatibility to be used to treat cyclomastopathy, and application method is simple, and curative effect is good, and relapse rate is low, has no adverse reaction.
Technical scheme of the present invention is following:
A kind of Chinese traditional compound medicine of treating cyclomastopathy comprises the following weight Chinese medicinal raw materials: Radix Bupleuri 8-12, Radix Paeoniae Alba 8-12, Radix Angelicae Sinensis 8-12, Poria 8-12, Rhizoma Cyperi 13-17, Radix Curcumae 8-12, Radix Salviae Miltiorrhizae 13-17, Spica Prunellae 8-12, Ramulus Cinnamomi 5-7.
Wherein method for preparing is that above-mentioned 9 flavor medical materials are cleaned, and proportional mixing, the 5-7 that adds medical material gross weight water or volume ratio doubly is that 75% ethanol decocts 2 times; Each 70 minutes, merge 2 times decoction liquor, filter; And concentrate, proportion is 1.16 fluid extract when obtaining 60 ℃, adopts conventional preparation technology; Chinese medicine preparation of the present invention can be made into said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
Spica Prunellae hard masses softening and resolving among the present invention; Radix Angelicae Sinensis, Radix Bupleuri depressed liver-energy dispersing and QI regulating, phlegm reduction of blood circulation promoting, promoting the circulation of QI to relieve pain; Radix Paeoniae Alba blood-supplementing blood-nourishing, easing the affected liver to relieve pain, suppressing liver-YANG; Poria promoting diuresis to eliminate damp pathogen, spleen-benefiting mind-tranquilizing; Radix Curcumae promoting blood circulation and stopping pain, promoting QI circulation for relieving depression; The Rhizoma Cyperi regulating qi and dredging collateral; All medicines share, and gas disappears along expectorant, and lump looses and removes pain relief.So the Chinese traditional compound medicine that the present invention makes is evident in efficacy, and relapse rate is low, has no adverse reaction.
Specific embodiment
Embodiment 1:
A kind of Chinese traditional compound medicine of treating cyclomastopathy comprises the following weight Chinese medicinal raw materials: Radix Bupleuri 8, the Radix Paeoniae Alba 8, Radix Angelicae Sinensis 8, Poria 8, Rhizoma Cyperi 13, Radix Curcumae 8, Radix Salviae Miltiorrhizae 13, Spica Prunellae 8, Ramulus Cinnamomi 5.
Wherein method for preparing is that above-mentioned 9 flavor medical materials are cleaned, proportional mixing, and 5 times the decocting that adds the medical material gross weight boils 2 times, and each 70 minutes, merge 2 times decoction liquor, to filter, and concentrate, proportion is 1.16 fluid extract when obtaining 60 ℃.
Embodiment 2:
A kind of Chinese traditional compound medicine of treating cyclomastopathy comprises the following weight Chinese medicinal raw materials: Radix Bupleuri 10, the Radix Paeoniae Alba 10, Radix Angelicae Sinensis 10, Poria 10, Rhizoma Cyperi 15, Radix Curcumae 10, Radix Salviae Miltiorrhizae 15, Spica Prunellae 10, Ramulus Cinnamomi 6.
All the other are with embodiment 1.
Embodiment 3:
A kind of Chinese traditional compound medicine of treating cyclomastopathy comprises the following weight Chinese medicinal raw materials: Radix Bupleuri 12, the Radix Paeoniae Alba 12, Radix Angelicae Sinensis 12, Poria 12, Rhizoma Cyperi 17, Radix Curcumae 12, Radix Salviae Miltiorrhizae 17, Spica Prunellae 12, Ramulus Cinnamomi 7.
Wherein method for preparing is that above-mentioned 9 flavor medical materials are cleaned, proportional mixing, and 5 times of volume ratios that add the medical material gross weight are that 75% ethanol decocts 2 times, each 70 minutes, merges 2 times decoction liquor, filter, and concentrated, proportion is 1.16 fluid extract when obtaining 60 ℃.
Embodiment 4:
A kind of Chinese traditional compound medicine of treating cyclomastopathy, wherein method for preparing is the medical material in the prescription to be cleaned proportional mixing; 6 times of volume ratios that add the medical material gross weight are that 75% ethanol decocts 2 times; Each 70 minutes, merge 2 times decoction liquor, filter; And concentrate, proportion is 1.16 fluid extract when obtaining 60 ℃.
All the other are with embodiment 1.
Embodiment 5:
A kind of Chinese traditional compound medicine of treating cyclomastopathy, wherein method for preparing is the medical material in the prescription to be cleaned proportional mixing; 6 times the decocting that adds the medical material gross weight boils 2 times, each 70 minutes, merges 2 times decoction liquor; Filter, and concentrate, proportion is 1.16 fluid extract when obtaining 60 ℃.
All the other are with embodiment 2.
Embodiment 6:
A kind of Chinese traditional compound medicine of treating cyclomastopathy, wherein method for preparing is the medical material in the prescription to be cleaned proportional mixing; 6 times the decocting that adds the medical material gross weight boils 2 times, each 70 minutes, merges 2 times decoction liquor; Filter, and concentrate, proportion is 1.16 fluid extract when obtaining 60 ℃.
All the other are with embodiment 3.
Embodiment 7:
A kind of Chinese traditional compound medicine of treating cyclomastopathy, wherein method for preparing is the medical material in the prescription to be cleaned proportional mixing; 7 times of volume ratios that add the medical material gross weight are that 75% ethanol decocts 2 times; Each 70 minutes, merge 2 times decoction liquor, filter; And concentrate, proportion is 1.16 fluid extract when obtaining 60 ℃.
All the other are with embodiment 2.
Embodiment 8:
A kind of Chinese traditional compound medicine of treating cyclomastopathy comprises the following weight Chinese medicinal raw materials: Radix Bupleuri 15, the Radix Paeoniae Alba 15, Radix Angelicae Sinensis 15, Poria 15, Rhizoma Cyperi 10, Radix Curcumae 5, Radix Salviae Miltiorrhizae 8, Spica Prunellae 5, Ramulus Cinnamomi 3.
A kind of Chinese traditional compound medicine of treating cyclomastopathy, wherein method for preparing is the medical material in the prescription to be cleaned proportional mixing; 7 times the decocting that adds the medical material gross weight boils 2 times, each 70 minutes, merges 2 times decoction liquor; Filter, and concentrate, proportion is 1.16 fluid extract when obtaining 60 ℃.
Embodiment 9:
A kind of Chinese traditional compound medicine of treating cyclomastopathy comprises the following weight Chinese medicinal raw materials: Radix Bupleuri 6, the Radix Paeoniae Alba 6, Radix Angelicae Sinensis 5, Poria 5, Rhizoma Cyperi 18, Radix Curcumae 18, Radix Salviae Miltiorrhizae 20, Spica Prunellae 10, Ramulus Cinnamomi 8.
A kind of Chinese traditional compound medicine of treating cyclomastopathy, wherein method for preparing is the medical material in the prescription to be cleaned proportional mixing; 7 times of volume ratios that add the medical material gross weight are that 75% ethanol decocts 2 times; Each 70 minutes, merge 2 times decoction liquor, filter; And concentrate, proportion is 1.16 fluid extract when obtaining 60 ℃.
Embodiment 10:
A kind of Chinese traditional compound medicine of treating cyclomastopathy comprises the following weight Chinese medicinal raw materials: Radix Bupleuri 7, the Radix Paeoniae Alba 12, Radix Angelicae Sinensis 7, Poria 13, Rhizoma Cyperi 12, Radix Curcumae 15, Radix Salviae Miltiorrhizae 12, Spica Prunellae 12, Ramulus Cinnamomi 4.
Wherein method for preparing is that above-mentioned 9 flavor medical materials are cleaned, proportional mixing, and 4 times water or the volume ratio that adds the medical material gross weight is that 75% ethanol decocts 2 times, each 70 minutes, merges 2 times decoction liquor, filter, and concentrated, proportion is 1.16 fluid extract when obtaining 60 ℃.
Embodiment 11:
Be disclosed a kind of Chinese medicine preparation of treating cyclomastopathy of patent of 200610152595.8 and preparation method thereof according to application number, comprise the following weight Chinese medicinal raw materials: Radix Bupleuri 10, Poria 15, the Radix Paeoniae Alba 15, Rhizoma Cyperi 10, Folium Citri tangerinae 15, Spica Prunellae 30, Radix Salviae Miltiorrhizae 30, Semen Persicae 10, Flos Carthami 10, Radix Angelicae Sinensis 10, Semen Vaccariae 10.
Wherein method for preparing is that above-mentioned medical material is mixed, and the decocting that adds 8 times of volumes boiled 3 hours, and the decocting that in medicinal residues, adds 5 times of volumes after leaching again boiled 3 hours, mixed twice filtrate, and through heating concentrate, quality inspection behind the fine straining, sterilization, pack, obtain finished product.Take 30ml, every day 3 times at every turn.
Embodiment 12:
According to application number is 200910147699.3 the disclosed a kind of Chinese medicine composition of treating mastopathy of patent, comprises following bulk drugs: Radix Angelicae Sinensis 82.5, Radix Bupleuri 82.5, Rhizoma Cyperi (vinegar system) 82.5, the Radix Paeoniae Alba (stir-fry) 82.5, Semen Vaccariae 82.5, Radix Paeoniae Rubra 82.5, Radix Salviae Miltiorrhizae 99, the Rhizoma Atractylodis Macrocephalae (stir-fry) 49.5, Poria 49.5, Pericarpium Citri Reticulatae 24.75, Pericarpium Citri Reticulatae Viride 24.75, Herba Taraxaci 45.
Get Radix Angelicae Sinensis, Radix Bupleuri, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae and extract medicinal residues and water and the whole decoctings twice of surplus medicine behind the volatile oil, each 8 times of water gagings decocted 2 hours; Filter merging filtrate, concentrating under reduced pressure (0.06 to-0.08MPa; 80 ℃) be 1.218 ± 0.010 (60 ℃ of heat are surveyed) to relative density, put cold rnning ethanol and make and contain the alcohol amount and reach 60%, get supernatant concentrating under reduced pressure (0.06 to-0.08MPa; 80 ℃) to relative density be 1.330 ± 0.012 clear paste of (60 ℃ of heat are surveyed), drying under reduced pressure (0.06 to-0.08MPa, 60 ℃); Pulverize, it is an amount of to add starch, mixing.Process granule, spray into volatile oil after the drying, encapsulated.Every day twice, each 2.
Embodiment 13: adopt conventional preparation technology, Chinese medicine preparation of the present invention can be made into said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
All the other are with embodiment 1-10.
Embodiment 14: the fluid extract of the mix homogeneously that will be made by embodiment 1-10 concentrates, and according to the operational approach of conventional tablet, adds pharmaceutic adjuvant; With each component mix homogeneously, wet granulation sieves; Adopt conventional tablet preparation method tabletting to process tablet, wherein each components contents is following:
Composition weight (part)
Mixed flow extractum 50
Starch 26
Microcrystalline Cellulose 16
Pulvis Talci 12
Polyethylene Glycol 8
All the other are with embodiment 1-10.
Embodiment 15: the fluid extract of the mix homogeneously that will be made by embodiment 1-10 concentrates, and according to the operational approach of conventional capsule, adds pharmaceutic adjuvant; With each component mix homogeneously; Granulate, adopt conventional capsule preparation method to fill and process capsule, wherein each components contents is following:
Composition weight (part)
Mixed flow extractum 100
Pregelatinized Starch 26
Lactis Anhydrous 18
Microcrystalline Cellulose 16
Calcium hydrogen phosphate 8
All the other are with embodiment 1-10.
Embodiment 16: the fluid extract of the mix homogeneously that will be made by embodiment 1-10 concentrates, according to the operational approach of conventional oral liquid, ethanol precipitation 1-2 time; Filter, concentrate aqueous precipitation; Filter, add pharmaceutic adjuvant, filter; The packing sterilization adopts conventional oral liquid preparation method to prepare oral liquid, and wherein each components contents is following:
Composition weight (part)
Mixed flow extractum 100
Ethanol 150
Sucrose 76
Sodium carboxymethyl cellulose 18
Oleum menthae 5
Sorbic acid 4
All the other are with embodiment 1-10.
The effectiveness study experiment:
Patient's data:
Choose 442 routine cyclomastopathy patients as object of study.Patient age 20～56 years old, average 35.1 years old; Bilateral hyperplasia 237 examples wherein, unilateral hyperplasia 2.5 examples.442 routine patients are divided into 13 groups at random, every group 34 example, 1 group as matched group, organizes as treatment for 12 groups.
Diagnostic criteria
According to the diagnostic criteria that China national surgery of Chinese medicine association breast disease special topic group is formulated, make a definite diagnosis through clinical health check-up and noctovisor scan.Clinical manifestation: distending pain of the breast and lump, part patient has periodically, and pain increases the weight of before the menstruation, alleviates behind the menstrual onset or disappears, and the whole menstrual cycle of part patient all has pain; Health check-up finds that a side or bilateral breast have diffuse thickening, can be confined to a mammary gland part, also can be scattered in whole mammary gland; Lump is graininess, nodositas or lamellar, and is not of uniform size, and matter is tough not hard; Normal is multiple, is found in a side, and lump and surrounding tissue boundary are unclear; Ultrasonic examination: the mammary gland body structure is disorderly, and echo is uneven.
Therapeutic Method:
Matched group:
Began oral medroxyprogestetone acetate, each 10 mg of tamoxifen, every day 2 times in intact the 3rd day from menstruation; Vitamin E, each 10 mg of B6, every day 3 times, the drug withdrawal in menstrual period was taken 3 months continuously.
The treatment group:
The Chinese medical concrete that embodiment 1-10 is made is 7 times of dilute with waters by volume respectively; Give 10 groups of treatment groups oral respectively from menstruation beginning in intact the 3rd day; Each 100ml, every day 2 times, drug withdrawal in menstrual period; Oral embodiment 11 and the Chinese medicine that embodiment 12 makes are organized in two groups of remaining treatments, take continuously 3 months.
Criterion of therapeutical effect
Efficacy assessment standard with reference to the thematic group formulation of Chinese national surgery of Chinese medicine association's breast disease.Clinical cure: lump disappears, and mastalgia disappears; Produce effects: the lump maximum gauge dwindles more than 1/2, and mastalgia disappears; Effectively: the lump maximum gauge dwindles less than 1/2, and mastalgia alleviates or lump dwindles more than 1/2, and mastalgia alleviates not obvious; Invalid: lump dwindles or increases hardening on the contrary, or simple mastalgia is alleviated.
12 groups of cyclomastopathy patients of table 1 clinical efficacy relatively
In therapeutic process: obvious adverse reaction does not appear in the treatment group, and the recurrence after 2 months of 2 examples is arranged.Amenorrhea 2 examples appear in matched group, feel sick and can not adhere to 1 example of treating, menoxenia person's 2 examples, the recurrence after 2 months of 5 examples.
Can find out that from therapeutic effect curative effect of the present invention obviously is superior to western medicine group, and be superior to the curative effect of the Chinese medicine medicine that similar prescription makes in the prior art, wherein best with the curative effect of embodiment 5, and have no adverse reaction.So the treatment by Chinese herbs cyclomastopathy that the present invention makes is evident in efficacy, and relapse rate is low, has no adverse reaction, and has shown the advantage of Chinese medicine cyclomastopathy.
Claims (5)
1. a Chinese traditional compound medicine of treating cyclomastopathy comprises the following weight Chinese medicinal raw materials: Radix Bupleuri 8-12, Radix Paeoniae Alba 8-12, Radix Angelicae Sinensis 8-12.
2. a Chinese traditional compound medicine of treating cyclomastopathy comprises the following weight Chinese medicinal raw materials: Radix Bupleuri 8-12, Radix Paeoniae Alba 8-12, Radix Angelicae Sinensis 8-12, Poria 8-12, Rhizoma Cyperi 13-17, Radix Curcumae 8-12, Radix Salviae Miltiorrhizae 13-17, Spica Prunellae 8-12, Ramulus Cinnamomi 5-7.
3. a Chinese traditional compound medicine of treating cyclomastopathy comprises the following weight Chinese medicinal raw materials: Radix Bupleuri 10, the Radix Paeoniae Alba 10, Radix Angelicae Sinensis 10, Poria 10, Rhizoma Cyperi 15, Radix Curcumae 10, Radix Salviae Miltiorrhizae 15, Spica Prunellae 10, Ramulus Cinnamomi 6.
4. like claim 2 or 3 said a kind of method for preparinies of treating the Chinese traditional compound medicine of cyclomastopathy, it is characterized by: 9 flavor medical materials are cleaned proportional mixing; The 5-7 that adds medical material gross weight water or volume ratio doubly is that 75% ethanol decocts 2 times, each 70 minutes, merges 2 times decoction liquor; Filter; And concentrate, proportion is 1.16 fluid extract when obtaining 60 ℃, adopts conventional preparation technology; Chinese medicine preparation of the present invention can be made into said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
5. a kind of method for preparing of treating the Chinese traditional compound medicine of cyclomastopathy as claimed in claim 4 is characterized by: above-mentioned 9 flavor medical materials are cleaned proportional mixing; 6 times the decocting that adds the medical material gross weight boils 2 times, each 70 minutes, merges 2 times decoction liquor; Filter; And concentrate, proportion is 1.16 fluid extract when obtaining 60 ℃, adopts conventional preparation technology; Chinese medicine preparation of the present invention can be made into said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
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| CN102600427A (en) * | 2012-03-27 | 2012-07-25 | 孟宪杰 | Chinese medicinal composition for treating hyperplasia of mammary glands and breast cancer |
| CN104587405A (en) * | 2015-02-04 | 2015-05-06 | 刘小芳 | Medicine for treating hyperplasia of mammary glands |
| CN104587318A (en) * | 2015-01-24 | 2015-05-06 | 柏伟伟 | Traditional Chinese medicine composition for treating hyperplasia of mammary glands caused by disharmony of thoroughfare and conception channels |
| CN107669942A (en) * | 2017-10-11 | 2018-02-09 | 王继显 | One kind treats proliferation of mammary gland medicine composition |
| CN110960651A (en) * | 2019-12-24 | 2020-04-07 | 曾庆琪 | Traditional Chinese medicine preparation with mammary gland hyperplasia resisting effect and preparation method and application thereof |
| CN111467446A (en) * | 2020-05-22 | 2020-07-31 | 云南省第一人民医院 | Traditional Chinese medicine prescription and preparation for treating hyperplasia of mammary glands and preparation method |
| CN116570698A (en) * | 2023-06-05 | 2023-08-11 | 长春中医药大学 | Traditional Chinese medicine composition for treating liver depression and qi stagnation type hyperplasia of mammary glands |
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| CN110960651A (en) * | 2019-12-24 | 2020-04-07 | 曾庆琪 | Traditional Chinese medicine preparation with mammary gland hyperplasia resisting effect and preparation method and application thereof |
| CN110960651B (en) * | 2019-12-24 | 2021-12-28 | 曾庆琪 | Traditional Chinese medicine preparation with mammary gland hyperplasia resisting effect and preparation method and application thereof |
| CN111467446A (en) * | 2020-05-22 | 2020-07-31 | 云南省第一人民医院 | Traditional Chinese medicine prescription and preparation for treating hyperplasia of mammary glands and preparation method |
| CN116570698A (en) * | 2023-06-05 | 2023-08-11 | 长春中医药大学 | Traditional Chinese medicine composition for treating liver depression and qi stagnation type hyperplasia of mammary glands |
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Application publication date: 20120314 |