CN1814217B - Chinese medicine composition for treating rheumatoid arthritis and preparation method thereof - Google Patents
Chinese medicine composition for treating rheumatoid arthritis and preparation method thereof Download PDFInfo
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- CN1814217B CN1814217B CN2005100618062A CN200510061806A CN1814217B CN 1814217 B CN1814217 B CN 1814217B CN 2005100618062 A CN2005100618062 A CN 2005100618062A CN 200510061806 A CN200510061806 A CN 200510061806A CN 1814217 B CN1814217 B CN 1814217B
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Abstract
The invention discloses a medicinal combination for curing rheumatic arthritis and the preparing method thereof, prepared of Jizhuali, Chinese Clematis Root, ant, Yanhusuo, seed of Job's tears, Swordlike Atractylodes Rhizome, etc. And its preparing method has the following steps of: weighing raw materials in the proportion, washing, drying in shade, slicing or breaking, soaking them in 45 deg. rice wine in the ratio of 1 to 5 for 15-30 days, then taking out, adding in proper amount of sugar, filtering, bottling, and making into wine preparation. The compound preparation made by the invention adopts an oral form, convenient to use, tasting good, and easy to be accepted by patients; in the clinic application, can treat both principal and secondary aspect of disease, having characters of good curative effect, short period of treatment, low price, and no strict indication or toxicity and side effect, as well as saving the curing expenses by above 60%.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation is a kind of Chinese medicine composition for the treatment of rheumatic arthritis and preparation method thereof.
Background technology
Rheumatic arthritis is a kind of clinical stubborn disease common, multiple, that the treatment phase is grown.At present, China's rheumatic arthritis, rheumatoid arthritis people increase year by year, by its rheumatoid arthritis (RA) be a kind of serve as the systemic autoimmune disease of main performance with chronic polyarthritis disease; pathological changes is mainly invaded synovium of joint, is connective tissues such as serous coat, the heart, lung, tremulous pulse, nerve, eye secondly; Except that arthritis, also can cause pericarditis, myocarditis, pleuritis, interstitial pneumonia, renal amyloidosis, eye part disease (as scleritis, iritis), concurrent vasculitis and peripheral lesion or the like are a kind of connective tissue diseases widely, therefore are referred to as rheumatoid disease again.Rheumatoid arthritis is normal invades a plurality of joints, from little joint onsets such as hands, foot, wrists, is symmetry, has chronic, outbreak repeatedly, characteristics that disability rate is high, brings heavy burden to patient and social family.The medicine that the extensive patients needs are effective, price is low, take medicine and easily adhere to.China has various rheumatism now, rheumatoid arthritis (motherland's medical science is referred to as arthromyodynia) patient accounts for 3% of total population, and promptly 4,000 ten thousand.Rheumatic arthritis, rheumatoid arthritis belong to the traditional Chinese medical science " arthromyodynia " category.Arthromyodynia, be meant that human body flesh table meridians suffer that wind and cold is damp and hot and wait the exopathogen invasion and attack after, QI-blood circulation is not normal, thereby causes limbs, joint etc. are located pain, epidemic disease Chu, numbness, weighed, joint stuffiness etc. is a kind of disease of main clinical manifestation.Because the degeneration of joint of patient's bone, common be that main pathological change takes place with cervical vertebra, lumbar vertebra, knee joint etc., and this sick the lighter sees that insufferable pain is main more, heavy then people's disability consequently.At present Western medicine is ntipyretic analgesic medicine such as aspirin, ibuprofen, indometacin etc. and anti-inflammatory analgetics such as hormone medicine such as ground plug miaow pine, prednisone to the common usefulness of treatment of this disease, suppress active rheumatism. come relief of symptoms, but can not solve root problem, and often recurrence, the medical expense height, side effect is big, and untoward reaction is many, makes patient be difficult to bear treatment.Though physical therapy and acupuncture and moxibustion therapy untoward reaction are less, its late result still seldom arrives certainly; The treatment by Chinese herbs untoward reaction is generally less, brings very big psychological burden but some Chinese patent medicine contains the inconvenience of toxic Chinese medicine bigger or that zest is stronger or its medicining mode inwardly to the patient.
Summary of the invention
Purpose of the present invention aims to provide and a kind ofly can either play fine treatment or relief of symptoms effect to rheumatic arthritis, has advantages such as good effect, the cycle is short, price is low, have no side effect, a kind of Chinese medicine composition that the patient is taken like a shot.It both can be used as medicine, and dosage is taken according to the rules, can be used as again to contain beverage and arbitrarily drink it.This also is a good job that promotes the well-being of mankind.
The present invention is according to understanding and the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs principle of the traditional Chinese medical science to rheumatic arthritis (arthromyodynia), according to traditional Chinese medical science prescription and preparation principle Chinese medicine composition is developed meticulously, realizes by following technical scheme:
The consumption of drug component of the present invention is groped to sum up to draw through the inventor in a large number, and each amounts of components all has curative effect preferably in following ranges, and medicine of the present invention contains
166～498 parts of 166～498 parts of Rhizoma Corydalis of 331～999 portions of Formica fuscas of Semen Hoveniae (Fructus Hoveniae)
110～330 parts of 110～330 parts of Radix Clematidis of 166～498 parts of Rhizoma Atractylodis of SEMEN COICIS
Preferable range is:
248～496 parts of 248～496 parts of Rhizoma Corydalis of 498～998 portions of Formica fuscas of Semen Hoveniae (Fructus Hoveniae)
165～275 parts of 165～275 parts of Radix Clematidis of 248～496 parts of Rhizoma Atractylodis of SEMEN COICIS
The weight portion of each raw material of optimizing is:
220 parts of 220 parts of Radix Clematidis of 331 parts of Rhizoma Atractylodis of 331 parts of SEMEN COICIS of 331 parts of Rhizoma Corydalis of 662 portions of Formica fuscas of Semen Hoveniae (Fructus Hoveniae).
Technical problem to be solved by this invention is to realize by following technical scheme.Be characterized in that with Semen Hoveniae (Fructus Hoveniae), Formica fusca, Radix Clematidis, Rhizoma Corydalis, SEMEN COICIS, Rhizoma Atractylodis etc. be the medicine that raw material is made.The rheumatismal pharmaceutical composition of this treatment is characterized in that it is that component is formed or made active component and pharmaceutically acceptable additives are formed or make active component and pharmaceutically acceptable additives are formed by the alcohol extract of following main materials by the water extract of following main materials by following main materials.The present invention has the merit of invigorating the liver and kidney, strong waist knee joint, wind-damp dispelling, Shujin blood by scientific combination, development meticulously, also has the effect of strengthening vital QI to eliminate pathogenic factors concurrently, and is particularly remarkable to various rheumatisms and pain effect.
Medicine of the present invention can adopt the Chinese medicine preparation conventional method to be prepared into any pharmaceutically useful conventional formulation.For example these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is made oral liquid then; But in order to make each crude drug of this medicine better bring into play drug effect, preferably the medicinal residues to crude drug Semen Hoveniae (Fructus Hoveniae), Radix Clematidis, Rhizoma Corydalis, SEMEN COICIS, Formica fusca, Rhizoma Atractylodis carry out special distillation extraction, but this can not limit protection scope of the present invention.
Described pharmaceutically acceptable additives are following one or more: glycerol, gelatin, Polyethylene Glycol, glycerol monolaurate (gelucire44/14), propylene glycol, dextrin, ethanol, dried starch, citric acid, sodium bicarbonate, ethyl hydroxybenzoate, tartaric acid, lecithin, sodium lauryl sulphate.
Described pharmaceutically acceptable additives are following one or more: glycerol, gelatin, Polyethylene Glycol, glycerol monolaurate (gelucire44/14), propylene glycol, dextrin, ethanol, dried starch, citric acid, sodium bicarbonate, ethyl hydroxybenzoate, tartaric acid, lecithin, sodium lauryl sulphate.
Its dosage form can be a said dosage form on any pharmaceutics, as syrup, granule, capsule, tablet etc.; Described capsule can be common capsule, effervescent capsule or other various suitable capsules; Described tablet can be common tablet, effervescent tablet, dispersible tablet or other various suitable tablets, can also can be not with suitable coating material coating
Coating; Preferred medicated wine.
The specific embodiment
Describe implementation of the present invention in detail below in conjunction with embodiment.
Embodiment 1: the preparation method of medicated wine of the present invention:
Semen Hoveniae (Fructus Hoveniae) 450 grams, Radix Clematidis 250 grams, Formica fusca 250 grams, Rhizoma Corydalis 400 grams, SEMEN COICIS 450 grams, Rhizoma Atractylodis 400 gram each component medicines are cleaned, dried in the shade, section or broken then, and be immersed at 1: 5 in proportion in the rice white spirit that is equivalent to 45 ° of spirituosity degree, its brew cycle is 15～30 days, take out to after date, it is an amount of to add white sugar, filters bottling and gets final product.
Embodiment 2:
The preparation method of syrup of the present invention:, each 1 hour, filter with Semen Hoveniae (Fructus Hoveniae) 500 grams, Formica fusca 500 grams, Radix Clematidis 250 grams, Rhizoma Corydalis 250 grams, SEMEN COICIS 500 grams, Rhizoma Atractylodis 500 gram decocting secondaries, merging filtrate, be condensed into thick paste, add the ethanol precipitation secondary, make to contain pure flow control and once reach 65%, for the second time reach 80%, filter, reclaim ethanol and be concentrated into about 700mL, stir molten with sucrose, ethyl hydroxybenzoate alcohol liquid while hot, add boiling water again to full dose, stir evenly promptly.
Embodiment 3:
The preparation method of dissolved granule of the present invention:
Semen Hoveniae (Fructus Hoveniae) 500 grams, Formica fusca 500 grams, Radix Clematidis 250 grams, Rhizoma Corydalis 250 grams, SEMEN COICIS 500 grams, Rhizoma Atractylodis 500 grams are pulverized said medicine and ground into coarser powder, the decocting secondary, 2 hours for the first time, 1 hour for the second time, to filter, filtrate is condensed into thick paste, dry, pulverized 100 mesh sieves, mixing, moistening, soften, take out when forming agglomerate, make dissolved granule.
In like manner, press the method for embodiment 3, add an amount of capsule etc.
Preparation tool fragrance medicated wine of the present invention, nontoxic, or sepia syrup or faint yellow granule or tablet or capsule.
More than during each forms, weight is calculated with crude drug, in the present invention, if weight is unit with the gram, this composition can be made into 1000 doses of pharmaceutical preparatioies, described 1000 doses of fingers, 1000 doses in the final drug preparation of making, as make 1000 in 1000 of capsule preparations, 1000 in tablet, granule 1000g, oral liquid 1000 peace bottles, injection 1000 peace bottles, drop pill etc., also can make big packing as granule, as the 100-500 bag, specifically can be 100 bags, 150 bags, 200 bags, 250 bags, 500 bags, every bag can be used as dose 1 time.This weight of formulation can increase or reduce, but the raw medicinal herbs weight proportion constant rate between each composition.
The present invention be at distinguished veteran doctors of TCM on the basis of proved recipe, through a large amount of preparation technology test and the resulting pure Chinese medicinal preparation of clinical practice.Treating both the principal and secondary aspects of a disease of the present invention, evident in efficacy, the improvement of various rheumatism symptoms and the rehabilitation of promotion patient body are had the obvious treatment effect.
Advantage of the present invention is to compare with similar Western medicine, it has reasonable recipe, drug resistance evident in efficacy, no and Drug resistance, has no side effect, treatment cycle is short, and low price the patient easily accept, taking convenience, mouthfeel be good, suitable advantage such as takes for a long time, is a kind of rheumatismal pure Chinese medicinal preparation that is used for the treatment of.
For a better understanding of the present invention, below further set forth medicine of the present invention at clinical action effect, but not to the restriction of effect of the present invention.
Concrete clinical practice is as follows:
1. clinical subjects: 90 examples in the treatment group of the present invention, male 60 examples, women 30 examples.52 examples are organized in treatment, matched group 38 examples, the course of disease 1～3 year.The general use 3 courses of treatment of medicine of the present invention, 3 months each courses of treatment.Matched group gives homemade ibuprofen 0.4g/ sheet oral, and every day three times, the time is the same with the medication group, takes 9 months continuously.Other matched group situation sees the following form.
2. clinical test results is as follows:
Characteristics of the present invention are:
1. be the All Pure Nature pharmaceutical preparation, have the merit of filling liver kidney, strong waist knee, wines used as antirheumatic, Shujin blood, its in clinical use good effect, the cycle is short, price is low, no strict indication and toxic and side effect;
2. the employing peroral dosage form is easy to use, and mouthfeel is good, and the patient easily accepts;
3. treat both principal and secondary aspect of disease, evident in efficacy, medical expense is low, but than the conventional therapy cost saving more than 60%;
4. hypertension, the careful usefulness of cardiac.
Claims (8)
1. pharmaceutical composition for the treatment of rheumatic arthritis, it is characterized in that: it makes active component by the water extract of following raw materials according and pharmaceutically receptible additives are formed, and the weight portion of each raw material is: 110～330 parts of 110～330 parts of Radix Clematidis of 166～498 parts of Rhizoma Atractylodis of 166～498 parts of SEMEN COICIS of 166～498 parts of Rhizoma Corydalis of 331～999 portions of Formica fuscas of Semen Hoveniae (Fructus Hoveniae).
2. a kind of pharmaceutical composition for the treatment of rheumatic arthritis according to claim 1, it is characterized in that: the weight portion of described each raw material is:
248～496 parts of 248～496 parts of Rhizoma Corydalis of 498～998 portions of Formica fuscas of Semen Hoveniae (Fructus Hoveniae)
165～275 parts of 165～275 parts of Radix Clematidis of 248～496 parts of Rhizoma Atractylodis of SEMEN COICIS.
3. a kind of pharmaceutical composition for the treatment of rheumatic arthritis according to claim 1, it is characterized in that: the weight portion of described each raw material is: 220 parts of 220 parts of Radix Clematidis of 331 parts of Rhizoma Atractylodis of 331 parts of SEMEN COICIS of 331 parts of Rhizoma Corydalis of 662 portions of Formica fuscas of Semen Hoveniae (Fructus Hoveniae).
4. a kind of pharmaceutical composition for the treatment of rheumatic arthritis according to claim 1 is characterized in that: described pharmaceutically acceptable additives are following more than one: glycerol, gelatin, Polyethylene Glycol, glycerol monolaurate, propylene glycol, dextrin, dried starch, ethylparaben, tartaric acid, citric acid, sodium bicarbonate, lecithin, sodium lauryl sulphate.
5. preparation of drug combination method for the treatment of rheumatic arthritis, it is characterized in that: the weight portion of each raw material is: 110～330 parts of 110～330 parts of Radix Clematidis of 166～498 parts of Rhizoma Atractylodis of 166～498 parts of SEMEN COICIS of 166～498 parts of Rhizoma Corydalis of 331～999 portions of Formica fuscas of Semen Hoveniae (Fructus Hoveniae); Comprise the steps:
Take by weighing each raw material by weight, said medicine is cleaned, dried in the shade, section or broken then, and be immersed at 1: 5 in proportion in the rice white spirit that is equivalent to 45 ° of spirituosity degree, its brew cycle is 15～30 days, takes out to after date, and it is an amount of to add white sugar, filter, medicated wine is made in bottling.
6. a kind of pharmaceutical composition for the treatment of rheumatic arthritis according to claim 1 is characterized in that: its dosage form is effervescent granule electuary, capsule or tablet.
7. a kind of pharmaceutical composition for the treatment of rheumatic arthritis according to claim 6 is characterized in that: described capsule is the effervescent capsule.
8. a kind of pharmaceutical composition for the treatment of rheumatic arthritis according to claim 6 is characterized in that: described tablet is effervescent tablet or is dispersible tablet, with suitable coating material coating.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2005100618062A CN1814217B (en) | 2005-12-05 | 2005-12-05 | Chinese medicine composition for treating rheumatoid arthritis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2005100618062A CN1814217B (en) | 2005-12-05 | 2005-12-05 | Chinese medicine composition for treating rheumatoid arthritis and preparation method thereof |
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| Publication Number | Publication Date |
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| CN1814217A CN1814217A (en) | 2006-08-09 |
| CN1814217B true CN1814217B (en) | 2011-02-16 |
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| CN2005100618062A Expired - Fee Related CN1814217B (en) | 2005-12-05 | 2005-12-05 | Chinese medicine composition for treating rheumatoid arthritis and preparation method thereof |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101698072B (en) * | 2009-10-30 | 2015-05-13 | 浙江医药高等专科学校 | Traditional Chinese medicine composite for treating rheumatic arthritis and preparation method thereof |
| CN102526327B (en) * | 2012-02-13 | 2013-09-18 | 李连君 | Compound Chinese herbal medicine for treating rheumatoid bone disease and preparation method for compound Chinese herbal medicine |
| CN103550741A (en) * | 2013-10-31 | 2014-02-05 | 谢坤 | Traditional Chinese medicinal preparation for treating rheumatism |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1312098A (en) * | 2001-02-21 | 2001-09-12 | 杨玉明 | A medicated liquor for treating arthralgia syndrome such as rheumatism and rheumatoid diseases |
| CN1485063A (en) * | 2002-09-26 | 2004-03-31 | 纪文华 | Chinese traditional medicine formulation for rheumatism and its orthopaedic disease |
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2005
- 2005-12-05 CN CN2005100618062A patent/CN1814217B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1312098A (en) * | 2001-02-21 | 2001-09-12 | 杨玉明 | A medicated liquor for treating arthralgia syndrome such as rheumatism and rheumatoid diseases |
| CN1485063A (en) * | 2002-09-26 | 2004-03-31 | 纪文华 | Chinese traditional medicine formulation for rheumatism and its orthopaedic disease |
Non-Patent Citations (2)
| Title |
|---|
| 李耀林.中医治疗类风湿性关节炎近况.广西中医学院学报第7卷 第3期.2004,第7卷(第3期),81-83. |
| 李耀林.中医治疗类风湿性关节炎近况.广西中医学院学报第7卷 第3期.2004,第7卷(第3期),81-83. * |
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| CN1814217A (en) | 2006-08-09 |
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Granted publication date: 20110216 Termination date: 20131205 |