CN116570698A - Traditional Chinese medicine composition for treating liver depression and qi stagnation type hyperplasia of mammary glands - Google Patents
Traditional Chinese medicine composition for treating liver depression and qi stagnation type hyperplasia of mammary glands Download PDFInfo
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- CN116570698A CN116570698A CN202310654024.8A CN202310654024A CN116570698A CN 116570698 A CN116570698 A CN 116570698A CN 202310654024 A CN202310654024 A CN 202310654024A CN 116570698 A CN116570698 A CN 116570698A
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Abstract
The invention belongs to the technical field of traditional Chinese medicine compositions, and discloses a traditional Chinese medicine composition for treating liver depression and qi stagnation type hyperplasia of mammary glands, wherein the traditional Chinese medicine composition for treating the liver depression and qi stagnation type hyperplasia of mammary glands comprises the following components by mass: 4:4:4:3:3:2:2. the invention applies the traditional Chinese medicine acupoint application therapy and the modern pharmaceutical transdermal absorption theory, adopts the traditional Chinese medicine composition acupoint application to treat hyperplasia of mammary glands, and has important clinical significance for relieving symptoms of patients with hyperplasia of mammary glands, improving life quality of people and relieving economic pressure and psychological pressure generated by treatment. The traditional Chinese medicine composition has the advantages of convenient administration method, durable medicine effect, no adverse reaction, definite curative effect, recovery rate of 70.0%, effective rate of 10%, effective rate of 12% and total effective rate of 92.0%, and is a safe, convenient and effective external treatment method for treating liver depression and qi stagnation type hyperplasia of mammary glands.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for treating liver depression and qi stagnation type hyperplasia of mammary glands.
Background
At present, the hyperplasia of mammary glands is a common disease and frequently-occurring disease of females, and along with the continuous increase of the current social pressure and family pressure, the situation that females visit due to breast pain and breast lumps is more and more, the hyperplasia of mammary glands has a tendency of rising year by year, and the emotion, work and life state of females are seriously influenced.
The traditional Chinese medicine for treating hyperplasia of mammary glands is also called hyperplasia of mammary glands, and clinically presents as follows: main evidence: pain of breast, scurrying pain; breast pain and/or mass are associated with menstrual and emotional changes; irritability; distention and fullness of the two hypochondrium areas.
The traditional Chinese medicine considers that the disease is the disease with the symptoms of deficiency and excess, the disorder of thoroughfare and conception vessels is the disease with the symptoms of liver qi stagnation and phlegm coagulation and blood stasis as the disease with the symptoms of pathogenesis. The disease is located in the liver, spleen and kidney. The traditional Chinese medicine considers that the principal disease is the treatment principle of the principal disease due to unsmooth emotion, stagnation of liver qi in milk, qi and blood obstruction, qi stagnation obstruction and pain obstruction, so qi-regulating and pain-relieving, blood activating and stasis removing. Hyperplasia of mammary glands is a common breast disease, and the onset age is any age from puberty to menopause, and 35-45 is the onset peak. The disease has complex pathogenesis and mild and severe symptoms, most of modern medical treatment diseases are hormone, operation and analgesic drug treatment, and the disease is easy to repeat and is not easy to be accepted by patients. The traditional Chinese medicine has unique advantages and potential for treating the disease, the period of oral traditional Chinese medicine is relatively long, and the traditional Chinese medicine is unacceptable to patients with difficult medicine taking. The hyperplasia of mammary glands caused by liver depression and qi stagnation is most common in clinic, mainly comprising breast pain, fullness and local tumor, and the 'li-yu' indicates that the external treatment is the internal treatment, and the 'Qing dynasty Xu Dachun' indicates that the decoction is insufficient … …, and the plaster is applied to block qi to make the medicine property enter the skin and pore from pores, activate collaterals, or be extracted, or attack and disperse, and is more powerful than the medicine taking. Meanwhile Xing Jianwei indicates that the traditional Chinese medicine acupoint application therapy can play the dual roles of medicine and meridian acupoints, and has the characteristics of wide application, definite and rapid curative effect, small side effect, convenient use and the like. Therefore, there is a need to design a new traditional Chinese medicine application for treating liver depression and qi stagnation type hyperplasia of mammary glands.
Through the above analysis, the problems and defects existing in the prior art are as follows:
(1) Modern medicine is mainly used for treating liver depression and qi stagnation type hyperplasia of mammary glands, and is mainly used for hormone, operation and pain relieving medicine treatment, and is easy to repeat and not easy to be accepted by patients.
(2) The period of the oral traditional Chinese medicine for treating the liver depression and qi stagnation type hyperplasia of mammary glands by using the traditional Chinese medicine is relatively long, and the oral traditional Chinese medicine is unacceptable to patients with difficult medicine taking.
Disclosure of Invention
Aiming at the problems existing in the prior art, the invention provides a traditional Chinese medicine composition for treating liver depression and qi stagnation type hyperplasia of mammary glands.
The invention is realized in such a way that the traditional Chinese medicine composition for treating liver depression and qi stagnation type hyperplasia of mammary glands is prepared from the following components in parts by mass: 4:4:4:3:3:2:2.
further, as a preferred mode, the traditional Chinese medicine composition for treating liver depression and qi stagnation type hyperplasia of mammary glands comprises 25g of vinegar radix bupleuri, 20g of vinegar rhizoma cyperi, 20g of radix salviae miltiorrhizae, 20g of radix paeoniae alba, 15g of rhizoma corydalis, 15g of rhizoma ligustici wallichii, 10g of radix curcumae and 10g of selfheal according to mass gram.
Another object of the present invention is to provide a method for using the traditional Chinese medicine composition for treating liver depression and qi stagnation type hyperplasia of mammary glands, the method for using the traditional Chinese medicine composition for treating liver depression and qi stagnation type hyperplasia of mammary glands comprises the following steps:
sequentially pulverizing radix bupleuri, rhizoma cyperi, radix salviae miltiorrhizae, radix paeoniae alba, rhizoma corydalis, rhizoma ligustici wallichii, radix curcumae and selfheal into powder, and mixing according to a mass ratio to obtain a dose;
heating water into the mixed powder obtained in the first step, uniformly mixing to form paste, uniformly subpackaging a pair of ointment, putting the paste into two external application bags, and uniformly pushing the ointment in the external application bags;
and thirdly, locking the seal of the external application bag and applying the seal to the part with the breast pain and the tumor on both sides, and judging the curative effect and evaluating the score after each treatment course is finished.
Further, the dose of the traditional Chinese medicine composition in the first step is as follows: 25g of vinegar radix bupleuri, 20g of vinegar rhizoma cyperi, 20g of radix salviae miltiorrhizae, 20g of radix paeoniae alba, 15g of rhizoma corydalis, 15g of ligusticum wallichii, 10g of radix curcumae and 10g of selfheal.
Further, the size of the dressing bag in the second step is 20 x 16cm.
Further, the thickness of the ointment in the second step in the external application bag is 2mm.
In the third step, the traditional Chinese medicine composition is applied for 2 hours each time, and 10 days is a treatment course.
Further, in the third step, every two courses of treatment are 2 days apart.
In the third step, the calculation formula of the improvement rate of the liver depression and qi stagnation type hyperplasia of mammary glands is as follows: the rate of improvement = [ (total integral of pre-treatment condition-total integral of post-treatment condition)/total integral of pre-treatment condition ] ×100%.
Further, the efficacy assessment criteria in step three are:
and (3) curing: the improvement rate is more than 90 percent;
the effect is shown: the improvement rate is 70-89%;
the method is effective: the improvement rate is 30-69%;
invalidation: the improvement rate is <30%.
In combination with the technical scheme and the technical problems to be solved, the technical scheme to be protected has the following advantages and positive effects:
firstly, the invention is an external pharmaceutical composition for treating liver depression and qi stagnation type hyperplasia of mammary glands, takes vinegar bupleurum as the monarch, takes qi-regulating and pain-relieving, takes nutgrass galingale rhizome, red sage root and white paeony root as the ministerial, takes qi-activating and blood-activating, soothing liver-qi-flowing, nourishing yin and softening liver, the rhizoma corydalis and the ligusticum wallichii are added to promote qi circulation and relieve pain, so that the radix curcumae and the selfheal can be used for relieving chest stuffiness and eliminating stagnation, the functions of liver-soothing, qi-regulating, vein relaxing and pain relieving are achieved, and breast pain, fullness, lump and the like caused by bad emotion of women can be rapidly relieved or eliminated. The invention applies the traditional Chinese medicine acupoint application therapy and the modern pharmaceutical transdermal absorption theory, adopts the traditional Chinese medicine composition acupoint application to treat hyperplasia of mammary glands, and has important clinical significance for relieving symptoms of patients with hyperplasia of mammary glands, improving the life quality of people and relieving economic pressure and psychological pressure generated by treating the diseases. The traditional Chinese medicine composition has the advantages of convenient administration method, durable medicine effect, no adverse reaction, definite curative effect, recovery rate of 70.0%, effective rate of 10%, effective rate of 12%, and total effective rate of 92.0%, and is a safe, convenient and effective external treatment method for treating liver depression and qi stagnation type hyperplasia of mammary glands.
Secondly, hyperplasia of mammary glands due to stagnation of liver-qi is most common in clinic, and mainly occurs due to breast pain, distension and local mass. In order to facilitate and effectively treat the liver depression and qi stagnation type hyperplasia of mammary glands and enrich the traditional Chinese medicine for treating the hyperplasia of mammary glands, the invention provides an external traditional Chinese medicine composition for treating the liver depression and qi stagnation type hyperplasia of mammary glands. The externally applied medicine for treating liver depression and qi stagnation type hyperplasia of mammary glands is specially developed for the type of hyperplasia of mammary glands, and has the characteristics of convenience in treatment, quick response, lasting efficacy, no time limitation and capability of easily completing treatment at home.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are needed in the embodiments of the present invention will be briefly described below, and it is obvious that the drawings described below are only some embodiments of the present invention, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
Fig. 1 is a flowchart of a method for using a traditional Chinese medicine composition for treating liver depression and qi stagnation type hyperplasia of mammary glands according to an embodiment of the present invention.
Detailed Description
The present invention will be described in further detail with reference to the following examples in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
Aiming at the problems existing in the prior art, the invention provides a traditional Chinese medicine composition for treating liver depression and qi stagnation type hyperplasia of mammary glands, and the invention is described in detail below with reference to the accompanying drawings.
The traditional Chinese medicine composition for treating liver depression and qi stagnation type hyperplasia of mammary glands provided by the embodiment of the invention comprises the following components by mass: 4:4:4:3:3:2:2.
preferably, the traditional Chinese medicine composition for treating liver depression and qi stagnation type hyperplasia of mammary glands provided by the embodiment of the invention comprises 25g of vinegar radix bupleuri, 20g of vinegar rhizoma cyperi, 20g of radix salviae miltiorrhizae, 20g of radix paeoniae alba, 15g of rhizoma corydalis, 15g of rhizoma ligustici wallichii, 10g of radix curcumae and 10g of selfheal according to mass gram.
As shown in fig. 1, the application method of the traditional Chinese medicine composition for treating liver depression and qi stagnation type hyperplasia of mammary glands provided by the embodiment of the invention comprises the following steps:
s101, sequentially pulverizing radix bupleuri, rhizoma cyperi, radix salviae miltiorrhizae, radix paeoniae alba, rhizoma corydalis, rhizoma ligustici wallichii, radix curcumae and selfheal into powder, and mixing according to a mass ratio to obtain a dosage;
s102, heating water into the mixed powder obtained in the S101, uniformly mixing to form paste, uniformly subpackaging a pair of ointment, putting the ointment into two external application bags, and uniformly pushing the ointment in the external application bags;
s103, locking the seal of the external application bag and applying the seal to the part with the lump on the two sides of the breast pain, and judging the curative effect and evaluating the score after each treatment course is finished.
The first dose of the traditional Chinese medicine composition in the step S101 provided by the embodiment of the invention is as follows: 25g of vinegar radix bupleuri, 20g of vinegar rhizoma cyperi, 20g of radix salviae miltiorrhizae, 20g of radix paeoniae alba, 15g of rhizoma corydalis, 15g of ligusticum wallichii, 10g of radix curcumae, and 10g of selfheal.
The size of the external application bag in step S102 provided in the embodiment of the present invention is 20×16cm.
The thickness of the ointment in the step S102 provided by the embodiment of the invention in the external application bag is 2mm.
In step S103 provided by the embodiment of the invention, the traditional Chinese medicine composition is applied for 2 hours each time, 10 days are a treatment course, and every two treatment courses are 2 days apart.
In step S103 provided by the embodiment of the present invention, the calculation formula of the improvement rate of liver depression and qi stagnation type hyperplasia of mammary glands is: the rate of improvement = [ (total integral of pre-treatment condition-total integral of post-treatment condition)/total integral of pre-treatment condition ] ×100%.
The efficacy evaluation criteria in step S103 provided by the embodiment of the present invention are:
and (3) curing: the improvement rate is more than 90 percent;
the effect is shown: the improvement rate is 70-89%;
the method is effective: the improvement rate is 30-69%;
invalidation: the improvement rate is <30%.
The technical scheme of the present invention will be further described in connection with pharmacological analysis.
Bupleurum root: it is pungent and bitter in nature and slightly cold in nature. It enters liver, gallbladder and lung meridians. Radix bupleuri was originally recorded in Shennong Ben Cao Jing (Shen nong's herbal): bupleuri radix, radix bupleuri, has effects of regulating heart and abdomen, removing qi stagnation in intestine and stomach, and promoting digestion due to accumulation of food and pathogenic cold and heat. Is taken for a long time, and has the effects of reducing weight, improving eyesight and replenishing essence. Zhang Xichun the "medical Zhong Shen xi Lu" considers that Bupleurum root is a person with liver qi being not smooth, which can be eased; for excessive internal heat, it can be dispersed. Zhang Zanchen Bupleurum root is assigned to the drug for relieving exterior syndrome and interior syndrome, soothing liver-qi stagnation and regulating menstruation. The functions are mainly used for dispelling and reducing fever, soothing liver and relieving depression, lifting yang qi, reducing fever and checking malaria. Can be used for treating common cold, fever, distending pain in chest and hypochondrium, menoxenia, uterine prolapse, and rectocele. The bupleurum has the functions of anti-inflammatory, antipyretic, antivirus, antibacterial, liver protection, anticancer, immunoregulation and the like, and is basically consistent with the main effects described by the traditional Chinese medicine. Modern pharmacological studies show that both the aqueous extract and the ethanol extract of bupleurum have analgesic effect on acetic acid torsion experiments; bupleurum root can reduce the pain level of patients.
And (3) rhizoma cyperi: pungent, sweet, slightly bitter and flat. Enter liver and triple energizer meridians. The functions of the medicine are mainly to soothe liver and relieve depression, regulate qi and relieve pain. Can be used for treating hypochondriac pain, breast pain, menoxenia, abdominal distention, abdominal pain during menstruation, and fetal movement. Ben Cao Zhengyi (materia Medica): the nutgrass galingale rhizome, rhizoma Cyperi, with very strong pungent flavor and strong fragrance, is used for treating qi stagnation. Compendium, compendium: pungent, slightly bitter, sweet and flat. Foot jueyin and hand shaoyang are combined with the action of qi-dispersing in the twelve main meridians and eight vessels. Compendium, compendium: the nutgrass galingale rhizome has the advantages of smooth qi, no cold, fragrant and fleeing, and has the advantages of being pungent and energy-resolving, slightly bitter and descending, slightly sweet and mild. The results of researching the antipyretic and analgesic effects of the extracts of the different solvents of the nutgrass galingale rhizome show that the alcohol extract of the nutgrass galingale rhizome has obvious antipyretic and analgesic effects and is characterized by quick response and long duration.
Dan Shen is bitter in flavor and slightly cold in nature. It enters heart and liver meridians. The main functions are activating blood circulation to remove blood stasis, dredging channels to relieve pain, clearing away heart-fire and relieving restlessness, cooling blood and resolving carbuncles. Can be used for treating chest pain, abdominal pain, hypochondrium pain, menoxenia, dysmenorrhea, amenorrhea, etc. due to blood stasis. Waterweed sense: the salvia miltiorrhiza, which is specially used for blood system, has the functions of promoting blood circulation and removing blood stasis by reaching viscera internally, so that the salvia miltiorrhiza accumulates and eliminates abdominal mass: the exterior is good for the joints and collaterals, so the waist and knees are healthy and the arthralgia is marked. Modern researches have shown that the chemical components in red sage root mainly comprise water-soluble and fat-soluble components, have sedative, hypnotic and anticonvulsant effects, and can increase the hypoxia tolerance of brain tissues and improve the sedative effect. Is beneficial to the spontaneous activity amplitude reduction of the cerebral cortex and the inhibition of the postthalamus nuclear pain discharge, thereby playing a role in protecting and regulating the metabolic function of the organism tissue, generating central analgesic effect and improving the oxygen utilization capacity of the organism tissue.
White peony root: bitter and sour in flavor and slightly cold in nature. The main functions are nourishing blood, regulating menstruation, astringing yin, stopping sweating, softening liver, relieving pain and suppressing liver yang. Can be used for treating menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, limb spasm pain, headache, dizziness, and blood deficiency and sallow complexion. Radix Paeoniae alba injection with tranquilizing, analgesic and anticonvulsant effects and paeoniflorin all have tranquilizing and analgesic effects. Modern pharmacological research shows that the total glucosides of paeony has analgesic effect and can strengthen the analgesic effect of morphine and coladine. Extract Jin Qiu materia medica, described in: for yin deficiency and yang hyperactivity, radix Paeoniae alba is used to supplement yin and yang; for yin excess and Yang Yu, it is usually indicated for diarrhea by taking radix Paeoniae Rubra to raise yin and guide yang.
Ben Cao Zhengyi (materia Medica): the Chinese herbaceous peony is used for treating abdominal pain, the Chinese herbaceous peony is used for tonifying spleen yin and taking qi dissipated by yin, the Chinese herbaceous peony is used for nourishing liver yin and softening rigid wood , and qi-moving herbs are used for directly folding liver and treating the liver with the characteristics of fierce qi, and the liver is cleared from the liver and the liver is softened. Paeonia root, radix Paeoniae is a general recipe for treating abdominal pain, fullness and distention, pain in heart and stomach, and distending pain in chest and hypochondrium. Materia medica true: the white peony root is liquid for astringing liver, and can astringe liver qi without causing qi to move. What is the non-astringing of yin fluid caused by excessive liver qi is what is the case for book-carrying functions of qi tonifying and restlessness relieving, sweat arresting and miscarriage preventing, distending and distending hypochondriac pain, lung distending and cough, carbuncle and swelling, and herniation and abdominal mass? Since liver qi is collected, the spleen and lung can be nourished by the earth An Zejin without earth, so the spleen and lung are self-regulating.
Rhizoma corydalis: pungent and bitter in flavor and warm in nature. Enter liver and spleen meridians. The main functions are activating blood, promoting qi circulation and relieving pain. Can be used for treating chest pain, hypochondrium pain, abdominal pain, amenorrhea dysmenorrhea, puerperal blood stasis, and traumatic injury. Compendium, compendium: yan Hu is indicated for all pains in the body due to qi stagnation in blood and qi stagnation in qi, so it is wonderful in use. Ben Cao Jing Shu (materia Medica): yanhusuo, which is warm and can smooth, and Xuan, which is smooth and can promote qi circulation; pungent can moisten and dispel, and dispel and activate blood. Materia medica true: rhizoma corydalis, no matter what blood is qi, is accumulated but not dispersed, can be taken with its power, and its nature is warm, so its qi and blood can be smooth, and its flavor is pungent, and its qi and blood can moisten and disperse, so it is often the sole effect of doing so. Ben Cao Zhengyi (materia Medica): rhizoma corydalis, though it is a herb for removing food stagnation and promoting blood circulation, is not specially indicated for removing blood stasis, so it can treat the disorder of qi and blood in the interior and exterior without dispersing, remove food stagnation and resolve stagnation, mainly all pains in the liver, stomach, chest and abdomen, and cover to break the chong and he in the middle energizer. Modern pharmacological studies show that corydalis tuber has obvious analgesic effect, and the total alkali of corydalis tuber is 40 when the analgesic effect of morphine is 100.
Ligusticum wallichii: pungent and warm in nature. Enter liver, gallbladder and pericardium meridians. The main functions are promoting blood circulation and activating qi-flowing, dispelling wind and relieving pain, and can be used for treating chest pain, chest and hypochondrium pain, traumatic injury swelling and pain, and rheumatalgia. Compendium, compendium: xiong Lao and Xiong Zhong Qi are also used as qi-flowing in blood. For liver-bitter and urgent, it is indicated for blood deficiency because of pungent and complementary actions. For being pungent and dispersed, it is suitable for qi stagnation. Materia medica Hui Yan: xiong Lao, an active herb for promoting blood circulation, and an active herb for activating qi-flowing are used for treating the symptoms of upward movement of the head and eyes, downward regulation of menstruation, depression of the middle energizer and qi in blood. Xin Xingyang, while entering the blood system, it can remove all wind and regulate all qi.
Yu jin is pungent, bitter and cold. It enters heart, liver and gallbladder meridians. Blood is the essential herb for resolving depression and resolving qi stagnation, and is used for treating depression. The main functions are activating blood and relieving pain, and the qi-moving solution Yu Ke is used for treating chest and hypochondrium stabbing pain, breast distending pain and amenorrhea dysmenorrhea. Materia medica derived sense and complement: for depression, it is indicated for failure to dissipate. Materia medica preparation: promoting qi circulation, resolving stagnation, relieving blood stasis. The experiment research shows that the curcuma injection has very obvious analgesic effect on pure mice.
Spica Prunellae: shen nong Ben Cao Jing (Shen nong's herbal), bitter, pungent and cold in flavor. Scrofula, mouse fistula, mass breaking, goiter and qi stagnation dissipating, swelling and damp arthralgia of foot and body weight reducing. Materia medica preparation: pungent, bitter and slightly cold, qi is pure yang. Liver and blood nourishing, liver fire relieving, internal heat relieving, and stagnation of qi resolving. Von willebrand encyclopedia (von willebrand corporation): qi is pure yang, tonifies blood vessels of jueyin, so it is indicated for night pain like spirit, with qi of pure decoction, but with turbid yin being removed and fire ear being depressed by jueyin. Yu Zhong Yao Jie is bitter in flavor, pungent in flavor, cold in qi, entering liver and gallbladder meridian of foot jueyin. Cool nutrient and purge heat, dispel swelling and resolve hardness, treat scrofula and goiter, bruise, metrorrhagia, leukorrhagia and white spot sweat. The modern pharmacological research results show that the selfheal aqueous extract and the selfheal alcohol extract all show good anti-tumor activity.
The external traditional Chinese medicine composition for treating liver depression and qi stagnation type hyperplasia of mammary glands provided by the embodiment of the invention takes monarch, minister, assistant and guide formula, takes bupleurum as monarch, assistant and guide formula, takes the ministerial, assistant and guide formula, takes nutgrass galingale rhizome, red sage root and white paeony root as ministerial, takes the ministerial, guide formula, takes the effects of soothing liver, relieving depression, nourishing yin, softening liver, promoting qi circulation, activating blood circulation, assisting with rhizoma corydalis and ligusticum wallichii as the means of promoting qi circulation and relieving pain, so that the functions of regulating qi, relieving pain, activating blood circulation and dredging collaterals are achieved by the whole formula together, and the pain of female breast distension can be relieved or eliminated rapidly.
The application method of the external traditional Chinese medicine composition for treating hyperplasia of mammary glands provided by the embodiment of the invention comprises the following steps: pulverizing the Chinese medicinal composition into powder, wherein the dosage is one dose according to the following amount: 25g of vinegar radix bupleuri, 20g of vinegar rhizoma cyperi, 20g of radix salviae miltiorrhizae, 20g of radix paeoniae alba, 15g of rhizoma corydalis, 15g of ligusticum wallichii, 10g of radix curcumae and 10g of selfheal. Heating water to mix uniformly into paste, putting a pair of ointment into two external application bags with the size of 20 x 16cm, pushing the ointment into the bags uniformly with the thickness of 2mm, locking the seal of the medicine bags, and finally applying the medicine bags to the positions with pain and tumor on the breasts at two sides, wherein each time lasts for 2 hours, 10 days is a course of treatment, each course of treatment is finished, and score evaluation is carried out. Two courses were 2 days apart. Taboo: is forbidden for patients with skin allergy of the traditional Chinese medicine composition.
1. And (3) judging curative effect: and (3) formulating a curative effect evaluation standard according to a reference standard for diagnosing mastoplasia and evaluating curative effect, which is passed by an eighth conference of the medical science and mastopathy professional committee of Chinese medical science in 2002.
2. Disease integral standard
(1) Breast pain:
the pain basis was divided into 6 points;
touching and pressing pain, no spontaneous pain is 12 points;
paroxysmal spontaneous pain 18 minutes;
persistent spontaneous pain, which does not affect life for 24 minutes;
sustained spontaneous pain, concomitant radiation, and 30 minutes of life.
(2) Bump hardness:
soft like normal glands 3 minutes;
tough, as the tip of the nose 6 minutes;
hard, as in the case of 9 points.
(3) Mass range:
limited to 1 quadrant and 1.5 minutes;
1-2 quadrants 3 minutes;
3-4 quadrants and 6 minutes;
5-6 quadrants and 9 minutes;
7-8 quadrants 12 minutes.
(4) Maximum mass diameter:
the maximum diameter is less than or equal to 2cm and is 3 minutes;
the maximum diameter is 2.1-5 cm and is 6 minutes;
the maximum diameter >5cm is 9 minutes.
(5) Accompanying symptoms: 5 symptoms of soreness and weakness of waist and knees, fullness in both hypochondrium, abnormal emotion, menstrual disorder and blood stasis discomfort, each of which is scored according to the following criteria: the score is unchanged by 3, the score is improved by 2, and the normal score is recovered by 1.
Total disease score = (1) + (2) + (3) + (4) + (5).
3. Efficacy assessment criteria
(1) Calculating an improvement rate: improvement rate = [ (total integral of pre-treatment condition-total integral of post-treatment condition)/total integral of pre-treatment condition ] ×100%.
(2) Efficacy assessment criteria:
and (3) curing: the improvement rate is more than 90 percent;
the effect is shown: the improvement rate is 70-89%;
the method is effective: the improvement rate is 30-69%;
invalidation: the improvement rate is <30%.
Statistics of treatment cases and treatment effects: according to the above regulations, 100 cases of hyperplasia of mammary glands are treated by the medicament of the invention, wherein 100 cases of female patients; age 18-50 years; the disease course is 30 days to 15 years.
100 clinical cases, the administration time is 3 courses.
The recovery rate is 70.0%; 70 people in total; age 18-40 years, course of disease 1-10 years;
the obvious efficiency is 10 percent: 10 people: age 30-45 years, course of disease 1-6 years;
the effective rate is 12 percent, the total number of the patients is 12, and the disease course is 6 months to 5 years;
the inefficiency is 8.0%; 8 people in total; the age is 40-50 years, and the course of the disease is 10-15 years.
The beneficial effects are that: the external traditional Chinese medicine composition for treating hyperplasia of mammary glands provided by the invention takes monarch, minister, assistant and guide formulas, takes bupleurum as monarch, and takes qi-regulating and pain-relieving, minister, nutgrass galingale rhizome, red sage root and white paeony root as minister, and takes the effects of soothing liver-qi stagnation, nourishing yin and liver, promoting qi circulation and activating blood, and rhizoma corydalis and szechuan lovage rhizome as assistant and guide and pain-relieving, so that the curcuma aromatica and the selfheal are used for clearing heat and relieving stagnation, and the whole formula plays the roles of regulating qi-regulating and pain-relieving, activating blood and dredging collaterals together, and can rapidly relieve or eliminate the pain of female breast fullness. The external traditional Chinese medicine composition for treating hyperplasia of mammary glands, provided by the invention, is applied to traditional Chinese medicine acupoint therapy, and the traditional Chinese medicine composition acupoint application is used for treating hyperplasia of mammary glands, so that the external traditional Chinese medicine composition has important clinical significance for relieving symptoms of patients with hyperplasia of mammary glands, improving life quality of people and relieving economic pressure and psychological pressure generated by treating the diseases.
The external traditional Chinese medicine composition for treating hyperplasia of mammary glands provided by the embodiment of the invention has the advantages of convenient administration method, lasting efficacy, less adverse reaction, recovery rate of 70.0%, obvious efficiency of 10% and effective rate of 12.0%. The total effective rate of the externally applied traditional Chinese medicine provided by the invention is 92.0%, and the externally applied traditional Chinese medicine is an effective treatment method for hyperplasia of mammary glands.
The foregoing is merely illustrative of specific embodiments of the present invention, and the scope of the invention is not limited thereto, but any modifications, equivalents, improvements and alternatives falling within the spirit and principles of the present invention will be apparent to those skilled in the art within the scope of the present invention.
Claims (10)
1. The traditional Chinese medicine composition for treating the liver depression and qi stagnation type hyperplasia of mammary glands is characterized in that the traditional Chinese medicine composition for treating the liver depression and qi stagnation type hyperplasia of mammary glands comprises the following components by mass: 4:4:4:3:3:2:2.
2. the traditional Chinese medicine composition for treating liver depression and qi stagnation type hyperplasia of mammary glands according to claim 1, wherein the traditional Chinese medicine composition for treating liver depression and qi stagnation type hyperplasia of mammary glands is preferably composed of 25g of vinegar-processed bupleurum, 20g of vinegar-processed nutgrass galingale rhizome, 20g of red sage root, 20g of white peony root, 15g of rhizoma corydalis, 15g of szechuan lovage rhizome, 10g of turmeric root-tuber and 10g of common selfheal fruit-spike according to mass gram.
3. A method of using a traditional Chinese medicine composition for treating liver depression and qi stagnation type hyperplasia of mammary glands according to any one of claims 1-2, characterized in that the method of using the traditional Chinese medicine composition for treating liver depression and qi stagnation type hyperplasia of mammary glands comprises the following steps:
sequentially pulverizing radix bupleuri, rhizoma cyperi, radix salviae miltiorrhizae, radix paeoniae alba, rhizoma corydalis, rhizoma ligustici wallichii, radix curcumae and selfheal into powder, and mixing according to a mass ratio to obtain a dose;
heating water into the mixed powder obtained in the first step, uniformly mixing to form paste, uniformly subpackaging a pair of ointment, putting the paste into two external application bags, and uniformly pushing the ointment in the external application bags;
and thirdly, locking the seal of the external application bag and applying the seal to the part with the breast pain and the tumor on both sides, and judging the curative effect and evaluating the score after each treatment course is finished.
4. The method of claim 3, wherein the dosage of the traditional Chinese medicine composition in the first step is as follows: 25g of vinegar radix bupleuri, 20g of vinegar rhizoma cyperi, 20g of radix salviae miltiorrhizae, 20g of radix paeoniae alba, 15g of rhizoma corydalis, 15g of ligusticum wallichii, 10g of radix curcumae and 10g of selfheal.
5. The method of claim 3, wherein the size of the external application bag in the second step is 20 x 16cm.
6. The method of using a traditional Chinese medicine composition for treating liver depression and qi stagnation type hyperplasia of mammary glands according to claim 3, wherein the thickness of the ointment in the second step in the external application bag is 2mm.
7. The method of claim 3, wherein in step three, each application of the composition is performed for 2 hours, 10 days as a course of treatment.
8. The method of using a traditional Chinese medicine composition for treating liver depression and qi stagnation type hyperplasia of mammary glands according to claim 3, wherein in the third step, every two courses of treatment are separated by 2 days.
9. The method of using a traditional Chinese medicine composition for treating liver depression and qi stagnation type hyperplasia of mammary glands according to claim 3, wherein in the third step, the improvement rate calculation formula of the liver depression and qi stagnation type hyperplasia of mammary glands is as follows: the rate of improvement = [ (total integral of pre-treatment condition-total integral of post-treatment condition)/total integral of pre-treatment condition ] ×100%.
10. The method of using a traditional Chinese medicine composition for treating liver depression and qi stagnation type hyperplasia of mammary glands according to claim 3, wherein the efficacy evaluation criteria in the third step are as follows:
and (3) curing: the improvement rate is more than 90 percent;
the effect is shown: the improvement rate is 70-89%;
the method is effective: the improvement rate is 30-69%;
invalidation: the improvement rate is <30%.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102370948A (en) * | 2011-11-17 | 2012-03-14 | 中国中医科学院中医临床基础医学研究所 | Chinese medicinal compound preparation for treating hyperplasia of mammary glands and preparation method thereof |
| CN102406899A (en) * | 2011-11-29 | 2012-04-11 | 宋爱民 | Chinese medicine preparation for treating hyperplasia of mammary glands |
| CN111346165A (en) * | 2018-12-24 | 2020-06-30 | 广西小咕噜生物科技有限公司 | External traditional Chinese medicine ointment for treating hyperplasia of mammary glands |
| CN113599480A (en) * | 2021-08-09 | 2021-11-05 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | Scraping oil for relieving hyperplasia of mammary glands symptoms and preparation method thereof |
-
2023
- 2023-06-05 CN CN202310654024.8A patent/CN116570698A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102370948A (en) * | 2011-11-17 | 2012-03-14 | 中国中医科学院中医临床基础医学研究所 | Chinese medicinal compound preparation for treating hyperplasia of mammary glands and preparation method thereof |
| CN102406899A (en) * | 2011-11-29 | 2012-04-11 | 宋爱民 | Chinese medicine preparation for treating hyperplasia of mammary glands |
| CN111346165A (en) * | 2018-12-24 | 2020-06-30 | 广西小咕噜生物科技有限公司 | External traditional Chinese medicine ointment for treating hyperplasia of mammary glands |
| CN113599480A (en) * | 2021-08-09 | 2021-11-05 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | Scraping oil for relieving hyperplasia of mammary glands symptoms and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 张霞, 郑彬彬: "乳癖清热饮治疗乳腺增生100例", 山东中医杂志, vol. 17, no. 01, 20 January 1998 (1998-01-20), pages 18 * |
| 王正林;: "从肝郁论治乳腺增生病", 山东中医杂志, vol. 27, no. 12, 5 December 2008 (2008-12-05), pages 818 * |
| 程生辉;: "消癖散治疗乳腺增生病90例临床观察", 山西中医学院学报, vol. 10, no. 03, 28 June 2009 (2009-06-28), pages 43 * |
| 钧凯;李瑞娟;关一伟;张菊新;张桂兰;耿新生;: "乳络通胶囊治疗乳腺增生380例", 中医研究, vol. 28, no. 04, 10 April 2015 (2015-04-10), pages 6 * |
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