CN102357199A - Traditional Chinese medicine for treating manus and tinea pedis - Google Patents
Traditional Chinese medicine for treating manus and tinea pedis Download PDFInfo
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- CN102357199A CN102357199A CN201110357840XA CN201110357840A CN102357199A CN 102357199 A CN102357199 A CN 102357199A CN 201110357840X A CN201110357840X A CN 201110357840XA CN 201110357840 A CN201110357840 A CN 201110357840A CN 102357199 A CN102357199 A CN 102357199A
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Abstract
The invention relates to a traditional Chinese medicine for treating manus and tinea pedis, which adopts alum (dried alum), melanterite, saponin, polygonatum rhizome and cortex lycii radicis as drug raw materials, and is prepared by process steps of mixing, crushing, well mixing, sieving, sterilization, and packaging. The whole formula has excellent effect of clearing heat and drying damp, killing worm and relieving itching, killing fungi and relieving edema, and has significant effect on treating manus and tinea pedis, especially sweat herpes manus and tinea pedis caused by damp-heat retention.
Description
Technical field
Content of the present invention belongs to the application and the preparing technical field of pharmaceuticals, relates to a kind of Chinese medicine that is used to treat tinea manus and pedis.
Background technology
Tinea manus and pedis is commonly called as beriberi, is a kind of extremely common fungal infection dermatoses.Medically usually tinea manus and pedis is divided into erosive type, antiperspirant alveolitoid and squama keratinization type, foot hyperhidrosis humidity or footgear stuffiness etc. all can be brought out primary disease, and it also often infects through publilc baths, the floor of edge of pool, bath towel, public slippers, the foot basin that pollutes.In the current colony of being grown up, about 70%～80% people has the different beriberi of weight, and the variation of Along with people's growth in the living standard and life style, the morbidity of primary disease grows with each passing day.According to statistics, the tinea manus and pedis patient accounts for 20%～30% among the department of dermatologry out-patient at present, and it is more especially to be engaged in hyperpyrexia high humidity environment worker prevalence in summer, can reach 40%～60%.Because this common frdquently encountered disease has suitable infectiousness and secondary infection property, thereby active drug is developed in its treatment had great social meaning.
The treatment of tinea pedis, in the Western medicine oral medicine of using at present has plain fragrant (ketoconazole), but it costs an arm and a leg, and human body is had liver injury; Medicine for external use mainly contains daktarin, clotrimazole, beriberi liquor, benzoic acid, salicylic acid etc., and they are many to be purpose with substance treatment fungus, does not have to change the effect that local skin helps the external environment condition of conk; And traditional Compound Flavescent Sophora and Salicylic Acid Powder external bath method is still undesirable to the therapeutic effect of acute erosion type tinea pedis.Except above-mentioned points, can supply on the market vast tinea pedis patient easy-to-use and have antipruritic, hidroschesis astriction and fungus and all effective medicine of antibacterial are also rarely had finding so far.
Summary of the invention
The objective of the invention is to overcome the deficiency that prior art exists, a kind of prescription science is provided, prepares Chinese medicine convenient, that tinea manus and pedis is treated in high being used to of curative effect.
Chinese medicine of the present invention is that the designer is in the clinical practice and research basis to the human body tinea manuum and tinea pedis for many years; Dialectically combine with differential diagnosis of diseases; To patient's disease; Through in addition selected to motherland's Chinese medicine resource and adopt advanced technology to make, the medicine material in the side is made up of Alumen (dried Alumen), Melanteritum, Fructus Gleditsia, Rhizoma Polygonati and Cortex Lycii compatibility, has fabulous heat clearing and damp drying; The function of killing parasites for relieving itching is particularly having significant effect to tinea manuum and tinea pedis aspect the treatment of the antiperspirant alveolitoid tinea manuum and tinea pedis due to the damp-heat accumulation.
Constituting the contained medicament active composition of Chinese medicine according to the invention is prepared by following portions by weight proportion raw material medicine:
Calcined Alumen 1～5 is forged Melanteritum 1～5,
Fructus Gleditsia 1～5, Rhizoma Polygonati 1～5,
Cortex Lycii 1～5.
Technical program of the present invention also lies in, constitute the contained medicament active composition of this Chinese medicine and prepare by following portions by weight proportion raw material medicine:
Calcined Alumen 1～3 is forged Melanteritum 1～3,
Fructus Gleditsia 1～3, Rhizoma Polygonati 1～3,
Cortex Lycii 1～3.
Technical program of the present invention also lies in, constitute the contained medicament active composition of this Chinese medicine and prepare by following portions by weight proportion raw material medicine:
Alumen (forging) 1, Melanteritum (forging) 1,
Fructus Gleditsia 1, Rhizoma Polygonati 1,
Cortex Lycii 1.
The method that is used to prepare a kind of powder of this Chinese medicine may further comprise the steps: after the medicine material of each parts by weight proportioning is mixed, be ground into fine powder, mixing is crossed 80 mesh sieves, sterilization, and packing promptly obtains being used to treat the Chinese powder medicine of tinea manus and pedis.
The function of medicine of respectively distinguishing the flavor of in the present invention prescription cures mainly with pharmacological action and is described below.
1. Alumen (dried Alumen)
[function cures mainly] external detoxifcation parasite killing, dampness removing to stop itchin; Hemostasis antidiarrheal for oral administration is dispeled wind-phlegm.External treatment is used for eczema, scabies, proctoptosis, hemorrhoid, pure discharging ear; For oral administration be used for incessant chronic diarrhea, have blood in stool, metrorrhagia, epilepsy go mad.The Alumen (calcined) removing dampness is held back skin ulcer, and hemostasisization is rotten, is used for eczema eczema, proctoptosis, hemorrhoid, engages discharging ear, pudendal pruritus leukorrhagia, epistaxis bleeding from the gum, nose hysteria meat.
[pharmacological action]
(1) antibacterial action: staphylococcus aureus and Bacillus proteus are had inhibitory action (test tube method); To escherichia coli, bacillus pyocyaneus, anthrax bacillus, dysentery bacterium (Fu Shi, will Hayes), Bacillus typhi, paratyphoid fever bacillus, Bacillus proteus, and staphylococcus, Candida albicans etc. also have obvious suppression to render a service (paper dish, flat band method); The strongest to viridans streptococci, Hemolytic streptococcus, streptococcus pneumoniae, diphtheria corynebacterium effect; Cattle type Brucella, bordetella pertussis, meningococcus effect are taken second place, hemophilus influenza is not had effect (paper disk method); The high concentration alum steep also has inhibitory action to human-like (H37RV) and bacillus tuberculosis bovis.
(2) anti-trichomonas vaginitis effect.
(3) effect of coagulated protein.
(4) choleretic effect.
(5) local irritant effect.
2. Melanteritum
[function cures mainly] detoxifcation dampness, parasite killing is enriched blood.Be used for general edema with yellowish skin distension, infantile malnutrition chronic dysentery, discharging fresh blood stool, blood deficiency and yellow complexion, eczema scabies, sore throat aphtha.
[pharmacological action]
Its effect of pharmacological evaluation proof and Alumen suppress for strong Candida albicans together.
3. Fructus Gleditsia
[function cures mainly] eliminated the phlegm and had one's ideas straightened out, mass dissipating and swelling eliminating.Be used for the apoplexy locked mouth, remain unconscious, the epilepsy abundant expectoration, close that key is obstructed, sore throat stagnation of phlegm, pertinacious phlegm are breathed with cough, expectoration is not well, constipation due to dry stool; The external treatment carbuncle.
[pharmacological action]
(1) antibacterial action: in test tube, Fructus Gleditsia has inhibitory action to some Gram-negative enteral pathogenic bacterium, and its water logging agent (1: 3) also has inhibitory action to some dermatophytes in test tube.
(2) phlegm-dispelling functions.
4. Rhizoma Polygonati
[function cures mainly] boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.Being used for deficiency of spleen-QI and stomach-QI, fatigue and asthenia, deficiency of stomach-Yin, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, chronic cough hemoptysis, asthenia of essence and blood, soreness of the waist and knees, early whitening of beard and hair, interior-heat quenches one's thirst.
[pharmacological action]
(1) resisting pathogenic microbes effect: in vitro tests shows, Rhizoma Polygonati water proposes liquid (1: 320) has inhibitory action to Bacillus typhi, staphylococcus aureus, acid-fast bacilli, and 2% Rhizoma Polygonati has inhibitory action in various degree to common pathomycete in sabouraud culture medium.
(2) anastalsis.
(3) antivirus action.
5. Cortex Lycii
[function cures mainly] removing heat from blood removes and steams the lung heat clearing pathogenic fire reducing.Being used for deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, cough due to lung-heat, spitting of blood, epistaxis, interior-heat quenches one's thirst.
[pharmacological action]
(1) antibiotic and antivirus action: with paper disk method antibacterial tests Cortex Lycii decoct Bacillus typhi, paratyphoid bacillus A, bacterium flexneri are had low bacteriostasis, but, tubercule bacillus is had weak inhibitory action to staphylococcus aureus unrestraint effect.The Cortex Lycii decoct has its cytopathic effect of inhibition to A-prime influenza (68-1 of capital section) Strain in embryonic kidney cell monolayer tissue culture of former generation.
(2) hypoglycemic activity.
(3) effect for reducing blood fat.
(4) refrigeration function.
The above-mentioned medicine material that is used to treat all meets " the regulation of relevant each kind of Chinese pharmacopoeia.Alumen master parasite killing in the side, dispel the wind, hold back wet detoxifcation and be monarch drug; Melanteritum dampness detoxifcation parasite killing, the Fructus Gleditsia mass dissipating and swelling eliminating, both are auxiliary each other to be ministerial drug; Cortex Lycii yin nourishing, heat clearing away have assists a ruler in governing a country first three herbal medicine and crosses dry fraud, thereby is adjuvant drug; The Rhizoma Polygonati priming is returned spleen, and not enough with replenishing vital essence and blood, the purpose that reaches guiding action is a messenger drug.So the above five tastes tie in, bring out the best in each other, make drug effect be able to give full play to, play removing damp-heat altogether, the function of killing parasites for relieving itching and reached the purpose of treatment tinea pedis.
The zoopery conclusion:
1, the present invention has antiinflammation, and its large and small dosage all highly significant antagonism Oleum Tiglii mixture causes the swelling reaction of mice ear, and can significantly reduce the permeability of acetic acid to the mouse peritoneal blood capillary;
2, the present invention has the painful effect in town, and the large and small dosage of external all can significantly improve the threshold of pain that hot plate causes mice;
3, the present invention has and reduces the traumatic superficial tissue of rabbit and ooze out and promotes the healing effect, can obviously shorten the traumatic wound surface of the rabbit ear and ooze out the extinction time and the healing time of forming a scab.
4, the present invention has the inhibition bacterial action, but moderate suppresses group B streptococcus, shigella flexneri, Bacillus typhi, bacillus subtilis, escherichia coli, anthrax bacillus, Bacillus proteus, bacillus typhi murium, Brucella, staphylococcus aureus and micrococcus catarrhalis;
5, the present invention has antifungic action, but moderate suppresses Candida albicans, trichophyton, microsporon gypseum, colter bacterium and actinomycetes;
LD when 6, Chinese medicinal powder of the present invention is oral
50＞40.2g/kg belongs to nontoxic level medicine;
7, the present invention does not all have the obvious stimulation effect to Cavia porcellus intact skin and damaged skin;
8, the present invention does not see obvious anaphylaxis to guinea pig skin.
In development process of the present invention, be further checking clinical efficacy of the present invention and safety, the designer selects 150 routine patients that drug powder treatment curative effect of the present invention has been carried out clinical observation, and the result is described below.
One, indication and diagnostic criteria:
(1) antiperspirant alveolitoid (rheumatism type): early, be dispersed in or bunch collection, form white small pieces desquamation, pruritus after a few days aspire to referring to (toe) distolateral or visible big vesicle of syringe needle of metacarpus.
(2) wiping type (damp-heat type) between: refer to that the flushing erosion is moistening between (toe), or secondary infection, the swelling sufferings are suppurated, concurrent lymph tubing and near lymph enlargement.
(3) squama keratinization type (blood-dryness type): xerosis cutis is coarse, split open, and winter more very.
Two, observation index:
(1) fills in (observing typing and curative effect time of occurrence before, during and after the treatment) by the registration form project demand.
(2) should do the fungus inspection of treatment front and back to the part model case, photo compared before and after the part model case was done to treat.
Three, the administrated method and the course of treatment:
(1) treatment group: wrap (1000g) every day one of the present invention, adds boiling water 1500ml, and medication is sooner or later soaked once, and each 20～30 minutes, the time spent need heat for the second time.
(2) matched group: the Compound Flavescent Sophora and Salicylic Acid Powder of selecting for use ChengDu Chinese Medicine Factory to produce.
(3) all case treatment viewing durations must not use the other treatment medicine.
(4) medication is with the judgement curative effect of exceeding in 10 days.
Four, curative effect determinate standard:
Cure: the symptom erythra disappears entirely, skin smooth, no desquamation vesicle.
Produce effects: transference cure, skin lesion disappears more than 2/3.
Take a turn for the better: the symptom skin lesion is handed over and is alleviated, but does not reach above standard as yet.
Invalid: symptom and skin lesion do not have all that improving or increases the weight of etc.
Five, case type and curative effect:
Three kinds of sick types of tinea manus and pedis; Pompholyx type, a wiping type, squama keratinization type amount to 150 examples; A pompholyx type and wiping type 96 example; Cure rate 68.8%, effective percentage are 97.9%.Squama keratinization type cure rate 16.7%, effective percentage are 81.5%.A pompholyx type and a wiping type curative effect are best; Compare P＜0.001 with the squama keratinization type significant differences is arranged.
The Compound Flavescent Sophora and Salicylic Acid Powder matched group: in 60 examples, pompholyx type cure rate is 15%, and effective percentage is 85%, a wiping type cure rate 40%, and effective percentage is 80%.Curative effect is low than tinea pedis eliminating medicine, and two groups of curative effects are through statistical procedures t=1.9623, and there is significant difference P＜0.05.
Fungus microscope examinations before and after 30 examples are treated: positive before the treatment, all negative after healing and the produce effects.
This medicine is not all found side effect in using.
In sum: the present invention truly has in clinic trial: the effect of dampness convergence, anti-inflammatory anti-itch, antibacterial detumescence, and after soaking first, many patients can feel that gargalesthesia obviously alleviates, soak 2～3 hyperhidrosis and reduce, rotten to the corn dry.Be applicable to that a pompholyx type and a wiping type and mixed infection person use, curative effect is high, instant effect.Because it is it is poor that the penetrating keratinization of tinea pedis eliminating medicine thickens the skin effect, therefore lower to squama keratinization type curative effect.The present invention of experiment proof particularly has the medicine of obvious curative effects because of the antiperspirant alveolitoid tinea manuum and tinea pedis due to the damp-heat accumulation for the treatment tinea manus and pedis.
The specific embodiment
Embodiment one
Get Alumen (forging) 12g, Melanteritum (forging) 12g, Fructus Gleditsia 12g, Rhizoma Polygonati 12g, Cortex Lycii 12g with the said medicine raw materials mix, is ground into fine powder, and mixing is crossed 80 mesh sieves, processes powder.
Embodiment two
Get Alumen (forging) 200g, Melanteritum (forging) 200g, Fructus Gleditsia 200g, Rhizoma Polygonati 200g, Cortex Lycii 200g with the said medicine raw materials mix, is ground into fine powder, and mixing is crossed 80 mesh sieves, processes powder.
Embodiment three
Get Alumen (forging) 100g, Melanteritum (forging) 60g, Fructus Gleditsia 50g, Rhizoma Polygonati 50g, Cortex Lycii 40g with the said medicine raw materials mix, is ground into fine powder, and mixing is crossed 80 mesh sieves, processes powder.
Embodiment four
Get Alumen (forging) 150g, Melanteritum (forging) 100g, Fructus Gleditsia 100g, Rhizoma Polygonati 80g, Cortex Lycii 70g with the said medicine raw materials mix, is ground into fine powder, and mixing is crossed 80 mesh sieves, processes powder.
Claims (4)
1. Chinese medicine that is used to treat tinea manus and pedis is characterized in that constituting the contained medicament active composition of this Chinese medicine and is prepared by following portions by weight proportion raw material medicine:
Calcined Alumen 1～5 is forged Melanteritum 1～5,
Fructus Gleditsia 1～5, Rhizoma Polygonati 1～5,
Cortex Lycii 1～5.
2. Chinese medicine according to claim 1 is characterized in that constituting the contained medicament active composition of this Chinese medicine and is prepared by following portions by weight proportion raw material medicine:
Calcined Alumen 1～3v forges Melanteritum 1～3,
Fructus Gleditsia 1～3, Rhizoma Polygonati 1～3,
Cortex Lycii 1～3.
3. Chinese medicine according to claim 1 is characterized in that constituting the contained medicament active composition of this Chinese medicine and is prepared by following portions by weight proportion raw material medicine:
Calcined Alumen 1 is forged Melanteritum 1,
Fructus Gleditsia 1, Rhizoma Polygonati 1,
Cortex Lycii 1.
4. method that is used to prepare the Chinese powder medicine of claim 1 or 2 or 3 described treatment tinea manus and pedis; It is characterized in that may further comprise the steps: after the medicine material mixing with each parts by weight proportioning, be ground into fine powder, mixing; Cross 80 mesh sieves; Sterilization is packed, and promptly obtains being used to treat the Chinese powder medicine of tinea manus and pedis.
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| CN201110357840XA CN102357199A (en) | 2011-11-11 | 2011-11-11 | Traditional Chinese medicine for treating manus and tinea pedis |
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| CN201110357840XA CN102357199A (en) | 2011-11-11 | 2011-11-11 | Traditional Chinese medicine for treating manus and tinea pedis |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104357243A (en) * | 2014-11-12 | 2015-02-18 | 骆志明 | Pure traditional Chinese medicine handmade soap solution capable of preventing and treating dermatophytosis |
| CN114209778A (en) * | 2021-12-29 | 2022-03-22 | 陕西医药控股集团天宁制药有限责任公司 | Composition for treating tinea manus and pedis and preparation process thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1887308A (en) * | 2006-04-29 | 2007-01-03 | 深圳市北科联药业科技有限公司 | Medicine for treating tinea manuum and tinea pedis and prepn of medicine cream |
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2011
- 2011-11-11 CN CN201110357840XA patent/CN102357199A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1887308A (en) * | 2006-04-29 | 2007-01-03 | 深圳市北科联药业科技有限公司 | Medicine for treating tinea manuum and tinea pedis and prepn of medicine cream |
Non-Patent Citations (4)
| Title |
|---|
| 《中国中西医结合杂志》 19970331 杨志波等 "复方二矾浸液治疗手癣的临床与实验研究" 第17卷, 第3期 * |
| 《西北药学杂志》 20050430 袁云刚等 "皂白散的质量标准研究" 第20卷, 第2期 * |
| 杨志波等: ""复方二矾浸液治疗手癣的临床与实验研究"", 《中国中西医结合杂志》, vol. 17, no. 3, 31 March 1997 (1997-03-31) * |
| 袁云刚等: ""皂白散的质量标准研究"", 《西北药学杂志》, vol. 20, no. 2, 30 April 2005 (2005-04-30) * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104357243A (en) * | 2014-11-12 | 2015-02-18 | 骆志明 | Pure traditional Chinese medicine handmade soap solution capable of preventing and treating dermatophytosis |
| CN114209778A (en) * | 2021-12-29 | 2022-03-22 | 陕西医药控股集团天宁制药有限责任公司 | Composition for treating tinea manus and pedis and preparation process thereof |
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Application publication date: 20120222 |