CN102335287A - Mixture capable of removing acnes and acne scars - Google Patents

Abstract

The invention relates to a mixture capable of removing acnes and acne scars, and belongs to the technical field of the manufacturing of skin external applied medicaments. The mixture is prepared by adding a certain quantity of auxiliary materials or matrixes into main raw materials which consist of rose hip oil and tea tree oil which serve natural plant essence oil and salicylic acid and citric acid which serve as chemical medicines. The mixture has the effects of treating whelks, pimples and the acnes, accelerating skin metabolism and effectively removing pock marks and the acne scars, so that skin is bright and clean; and the defects that only the acnes are removed but the acne scars are not removed by products sold in the market or the prior art are overcome.

Description

A kind of can anti-acne, the mixture of anti-acne seal

One, affiliated technical field

The invention belongs to external preparation for skin medicine manufacturing technology field, belonging to natural plant essential oils Rosehips oil, tea tree oil and the acid of chemical medicinal liquid poplar, citric acid specifically is primary raw material, adds the processing of a certain amount of adjuvant or substrate and next product.These article have treatment comedo, skin sore, acne, and can quicken skin metabolism, effectively dispel pox speckle, pox seal, make skin bright and clean, bright.

Two, background technology

Pox is being commonly called as of acne, is " comedo ", " skin sore " or " acne " again, is one of modal sick kind of beauty treatment skin section, except that the child, has 80%～90% people to suffer from primary disease or once suffered from primary disease (comprising light disease) among the crowd approximately.The clinical manifestation of comedo is: red, swollen, bitterly, and there is small number of patients to show as blackhead, hoary hair's acne, pustule, pimple, tuberosity etc.Comedo is a kind of dermatosis by what hair follicle and sebaceous gland are blocked, inflammation caused.During adolescence, intravital hormone meeting stimulating hair growth promotes more heavy wool fat of smegma, and therefore hair and sebaceous gland pile up many materials, make oils and fats and antibacterial attach work, cause the reaction of red swelling of the skin.By the common what youth of both sexes of this symptom of what, be " comedo " so just claim it.In fact, teenager not necessarily all can long comedo, and comedo is also not necessarily only long on one's body teen-age.

In the product for resolving poxes of listing,, all there is an anti-acne now, not the characteristics of anti-acne speckle, pox seal no matter be Chinese medicine or chemical medicine.Background technology contrast: patent name: a kind of compositions with acne-removal function.Country origin: China, number of patent application: 200810073731.3, a kind of compositions with acne-removal function is mainly processed by following weight portion raw material: Herba Rosmarini Officinalis 0.5～10, Folium Pini 0.5～10.Also can add Oleum lavandula angustifolia, the natural anti-acne composition of Camellia sinensis wet goods simultaneously, and/or chemical anti-acne composition such as vitamin B6, allantoin.Said composition can add medicine or cosmetics acceptable auxiliary, processes medicine or cosmetics, can effectively suppress the epidermis fat secretion, suppresses the acne growth, and the redness that disappears is killed the acne bacillus, and the anti-acne determined curative effect is safeguarded skin health.And needed raw material source is wide, production cost is low, safely, have no side effect.This contrast invention primary raw material be Herba Rosmarini Officinalis, Folium Pini, Oleum lavandula angustifolia, tea tree oil or vitamin B6, allantoin etc., the product therapeutic efficiency is the oil-control secretion, eliminates red and swollen; Kill the acne bacillus; And ignored dispeling the treatment of the pox speckle that stays after the acne, pox seal, we can say that the anti-acne seal of not dispelling is the real picture of this invention, lack treatment based on listing product and prior art to pox speckle, pox seal; My decision research is a kind of can either anti-acne, again can the anti-acne speckle, the product of pox seal.The contrast invention with common ground of the present invention is: tea tree oil is one of prescription raw material.

Three, summary of the invention

1. the purpose of invention statement: in the product for resolving poxes of list marketing and the existing correlation technique; Most product for resolving poxes has only anti-acne, antiinflammatory, antibacterial usually, improves the effect of pox property skin; And do not dispel the function of pox speckle, pox seal; For a long time, pox speckle, pox seal is perplexing always and is staying the patient of pox speckle, pox seal on the face.The present invention is perplexing always and is staying the patient of pox speckle, pox seal on the face in order to help patients with acne to dispel acne, pox speckle, pox seal.The present invention is in order to help patients with acne to dispel the problem of acne, pox speckle, pox seal.Address this problem, must add: one, have the composition of antibacterial, anti-inflammatory effect, two, the composition of Pear Power skin-active effect, three, have the effective ingredient that quickens skin metabolism etc. in when design prescription.These article have treatment comedo, skin sore, acne, and can effectively dispel pox speckle, pox seal, quicken skin metabolism, make skin bright and clean, bright.The present invention has overcome an existing product for resolving poxes anti-acne, not the shortcoming of anti-acne speckle, pox seal.

3. detailed description of the present invention

3.1 the mechanism of action: the present invention is by anti-inflammation and sterilization composition-tea tree oil, and the skin-active composition-Rosehips oil of whitening, acceleration skin metabolism composition-salicylic acid, citric acid are formed, and become the product of homogenizing through certain processes.The present invention prescription is not simple composition combination, but according to Chinese medicine dialectical execute control, wholistic therapy is guideline, adopts tea tree oil antiinflammatory, antibacterial; Peppermint Extract, Rosehips oil are whitened, skin moistening, reparation damaged skin, remove cutin in conjunction with salicylic acid; Quicken skin metabolism, the auxiliary salicylic acid of citric acid quickens skin metabolism, makes skin bright, bright and clean; Each component synergism of writing out a prescription produces whole therapeutic effect, thereby has realized dispeling the effect of acne, pox speckle, pox seal.In the present invention, use behind tea tree oil, Rosehips oil, salicylic acid and the citric acid mix homogeneously, produced the effect that anti-acne, anti-acne are printed.

3.3 the present invention is that primary raw material processing comes with natural plant essential oils Rosehips oil, tea tree oil and the acid of chemical medicinal liquid poplar, citric acid.

3.3,1 prescription proportioning: Rosehips oil: 60g-80g, tea tree ethereal oil: 20g-50g, salicylic acid: 5g-10g, citric acid 3g-6g adds adjuvant or substrate is an amount of, makes 1000g.

3.3.2 therapeutic efficiency: these article have treatment comedo, skin sore, acne, and can quicken skin metabolism, effectively dispel pox speckle, pox seal, make skin bright and clean, bright.

3.1 raw material

3.1.1 Rosehips oil: rose-seed oil Rose hip seed Oil; Chinese generally is called Rosehips oil Rose hip Oil; Rosehips oil is a kind of wild rose fruit of South America; Via special new science and technology method refine, extraction concentrates and forms, and do not contain the pure natural plant oil of any chemical analysis, antiseptic.Its Main Ingredients and Appearance is made up of multiple unsaturated fatty acid, vitamin C, fruit acid, the acid of soft or hard ester, oleum lini and sunlight filterable agent.

3.1.1.1 day use effect: the deep layer Glycerin, provide and support part, prevent skin aging, drying; Increase vigor of skin tissue, avoid lax, keep the skin high resilience, shrink coarse pore, can make dry and cracked skin recover its brilliance naturally, eliminate and reduce all kinds of wrinkles of skin forming, like eye pouch stricture of vagina, crows-feet, neck stricture of vagina; Prevent that ultraviolet from damaging skin, skin whitening.Special treatment: improve and eliminate new and old cicatrix after the wound, the cicatrix that stays after the concavo-convex hole that stays like comedo, skin sore, sunburn, burn scar, the operation.Blackout and the red and swollen phenomenon behind the skin changed in elimination.Prevent and eliminate striae gravidarum; Prevent pigementation, spot fading, the black speck that disappears, freckle, senile plaque, chloasma, eye-care can be eliminated black eye, eye fat granule, meat tooth, verruca plana.

3.1.1.2 Rosehips oil composition: γ-linoleic acid, unsaturated fatty acid, Palmic acid, citric acid, vitamin A, C, carotenoid.Be suitable for: most important composition is the r-linoleic acid, and this essential fatty acid is very helpful to reproductive system, edible can aging resistance, to arthritis, hypertension and hypercholesterolemia are also imitated.For skin, soft skin is arranged, whiten, wrinkle resistant, also effective in cure to striae gravidarum.Function with tissue regeneration can effectively be improved cicatrix, skin sore, comedo, keeps the moisture of skin effect remarkable, also can prevent pigementation after the Exposure to Sunlight, and it is all effective tan severely, and it is just much of that to add 10% amount, if not the normal dry skin that wears out can use 100%.

3.1.1.3 Rosehips oil speciality: deep yellow or filbert, light bitterness.Extraction is from the performance optimal of Chilean Flos rosae multiflorae fruit.The young fruit of squeezing Flos Rosae Rugosae just can obtain rose-seed oil.The high mountain of South America more than 3000 meters, the pollution-free Flos Rosae Multiflorae of aboriginal's plantation, the locals is called Rosa mosqueta (Spanish or Italian).Its most important composition is to contain gamma-Linolenic acid oil, and this essential fatty acid is very helpful to reproductive system.On edible, its aging-resistant function is also excavated gradually, so all effective to multiple sclerosis, arthritis, hypertension and hypercholesterolemia.

3.1.1.4 the scope of application of Rosehips oil: be applicable to various skin matter, improve cicatrix, eczema or dry and cracked hair quality; The main effect of Rosehips oil: the enhanced tissue effect, produce active function of organization, permeate skin corium easily, preserve moisture, promote the smooth effect of whitening of skin.Pair cell regeneration, maintenance and healing have splendid effect.It can make the skin pigment desalination, reappears homogeneous hue, makes skin level and smooth.It can keep skin clean, and soft, soft, moistening, deflation is solid, the effect of high resilience, Feng Li.Especially general coarse skin is more seen effect.The main effectiveness of Rosehips oil: cicatrix: stay the pox scar of cicatrix after maintenance face and the operation, level and smooth convex-concave hole tightens up pore, the dissolving blackhead.Wrinkle: prevent wrinkle, comprise the eye crows-feet, striae gravidarum, the body stricture of vagina, and can help to drive and wear out in a short time with dimness and eliminations such as wrinkle and smooth cuts, slow down aging occurs.Black speck: the prevention black speck, the formation of freckle and chloasma makes the black speck desalination to disappearing, and recovers pure white beauty.Burn: general burn or scald and to alleviate pain and wound restores fast.Sunburn: the fierce sun is tanned severely too for a long time, lowers pain rapidly and eliminates red and swollen with the back.Do rough: make the coarse wet skin of doing, dried exhaust quick-fried strong obstinate skin and rich and honour hands smoothly moistening, prevent moisture content loss protective layer, recover the original careful gloss of skin.Trace is itched: eliminate general skin pruritus, and extremely helpful to dry skin.The tire seal: tire seal too of a specified duration of general time takes longer, just can lightly in a short time move back like tire scar and the fat granule that stays in the recent period.Hair care: moisten and preserve moisture healthy hair and repair the hair of dry jag and damage.Red and swollen: all have mosquito to hinder, bite, and it is also wilful as early as possible former that skin sensitivity causes that red swelling of the skin can be eliminated misery rapidly.Skin protection: even if do not have the skin problem can both maintenance skin, Feng Li more with 2 Rosehips oil every day.

3.1.1.5 the cosmetic applications of Rosehips oil

3.1.1.5.1 repair function: eliminate cicatrix and pit.

The Rosehips quintessence oil is all effective to the skin injury cicatrix that causes because of acne, operation, burn, chickenpox, wound and otch; The dissolving blackhead; Pore refining; Eliminate red and swollen erythema, strong cell regeneration of Rosehips oil and wound healing function make for good health, the growth of normal skin, substitute scar tissue.It can not only construct damaged skin texture again, and can also improve the color and the elasticity of skin.

3.1.1.5.2 Firm reduce wrinkle function: prevent skin aging

Rosehips oil can improve skin regeneration and updating ability through the activity that promotes epidermis cell; Thereby stop and reversing classical symptom that skin aging produces such as wrinkle, canthus wrinkle and lax; Along with the disappearance of catabiosis, the skin of face consolidation and more smooth that will become.

3.1.1.5.3 whitening function: alleviate pigmentation

It can promote the ability of the new cell of skin hyperplasia, and along with new cell replaces aged cell, pigment Shen speckle and will alleviate gradually.Rosehips oil can also alleviate because the pigment that gestation causes is repaired sunburn skin, and desalination black speck freckle is recovered tender flour hole.

3.1.1.5.4 nourishing and moisturizing function: the exsiccant skin of preserving moisture again

The secreted oils and fats of four or five ten years old skin has reduced 10 times during than more than 20 year old, will be caused the generation of drying and dehydrating and wrinkle by the disappearance of excretory minimizing of what skin oil and fat and moisture-keeping functions.Rosehips oil can recover the optimum balance between fatty acid and the moisture, the exsiccant skin of preserving moisture again.

Rosehips oil is suitable for skin matter

3.1.1.6 be applicable to any skin matter, be particularly suitable for hydropenia, maturation, aging skin, the skin of speckle and sunburn occurs, soft skin is arranged, whiten, wrinkle resistant and striae gravidarum skin had good curative effect.The function of tool enhanced tissue effect and tissue regeneration, pair cell regeneration, maintenance and healing have splendid effect, can effectively improve cicatrix, skin sore, comedo.To keeping the moisture of skin effect distinguished, produce active function of organization, permeate skin corium easily, preserve moisture, make skin level and smooth.It can make skin pigment desalination, reappears homogeneous hue and promotes the smooth effect of whitening of skin, also can prevent pigementation after the Exposure to Sunlight, sunburn even all effective to psoriasis, eczema.It can keep skin clean, and soft, soft, moistening, deflation is solid, the effect of high resilience, Feng Li.Especially general coarse skin is more seen effect.

3.1.1.7 the strong quality of Rosehips oil and special rich nutrient contents, oiliness skin matter preferably is no more than 10% with the concentration of the skin matter use Rosehips oil of long small pox.

3.1.2 tea tree oil: general introduction

Tea tree oil is the pure natural plant quintessence oil that from the wood Myrtaceae Folium Melaleucae Leucadendrae of port, extracts with the distillation mode, the former Australia state of originating from.Land in navigation once at the Captain Cook of Britain in 1770 and to find when explore in Australia that leaf that local Maori adopts a kind of tanginess boils tea and drinks; Therefore with this kind of plant " Camellia sinensis "; Simultaneously Maori's accidental cuts of working is in the open air just taken wild leaf of tea tree at once conveniently and is smash paste; The Camellia sinensis foliar application of smashing paste just can be fully recovered in the affected part very soon, and their leaf of tea tree that also can smoulder is alleviated congested phenomenon, and Captain Cook produces very big curiosity; Just gather a lot of leaf of tea tree in the locality and take back Britain and give chemist analysis and research, this is the human beginnings of formally studying tea tree ethereal oil with science mode and attitude.

3.1.2.1 tea tree ethereal oil has the wide spectrum antimicrobial, and is antibacterial, environmental protection, and gentle natural faint scent, pollution-free non-corrosiveness, permeability is strong, gentle antiinflammatory.Gentle topical pain relief bitterness, biological strong grand Xie Jili, anthelmintic, the effect of killing demodicid mite, the treatment acne, acne has special effect, and its unique fragrant strongly fragrant abnormal smells from the patient helps refreshment.

3.1.2.2 definition: " tea tree oil " is a trade name; Press the correct definition on the botany; It should be called as titrol; Because it is mainly from several plants of Myrtaceae (Myrtaceae) Melaleuca (MelaleucaL.); Its topmost a kind of Melaleuca Alternifolia (Melaleuca alternifolia) that is called, accessory plant have bag squama Cortex Melaleucae leucadendrae (Melaleuca bracteata), Folium Photiniae (Folium Photiniae serrulatae) Cortex Melaleucae leucadendrae (Melaleuca ericifolia), white oil tree (Melaleuca quinquenervia), niaouli (Melaleuca Viridiflora) etc.The fresh branch and leaf of Melaleuca Alternifolia can get colourless to flaxen quintessence oil through steam distillation.

3.1.2.3 effect

Tea tree oil is applied to the healthy articles for use of personal care articles (hair nursing, body care, foot lotion, soap, antimicrobial form handwashing liquid, the clean agent of breath freshening and oral care implement); (first aid emulsion, antibacterial, burn nursing, antifungal, mycete) can play that antiinflammatory is antibacterial, only quiet, antipruritic, tea tree oil has got into U.S. food, drug surveilance office " FDA " buying list.

3.1.2.4 the place of production

The former Australia of being born in of Melaleuca Alternifolia, main product is in Australian southeastern coast (along New South Wales northern coastal), so this quintessence oil is claimed Australia tea tree oil again.Australia tea tree oil is not a new product; People know the existing quite long history of this quintessence oil; But greatly developing of this quintessence oil but is nearly one, vicennial thing; Particularly after people had known its strong disinfecting health-care effect, under the trend of back to nature, uphold nature promoted, the exploitation of this quintessence oil just was able to advance by leaps and bounds.Titrol is a kind of pistac or water white working fluid almost, has warm hot fragrantly, is with fragrant terpenoid breath, lets people remember the fragrance of nutmeg, Semen Phaseoli bandit and Gan Adeps Bovis seu Bubali, but the fragrance of terpenes and terpineol is more outstanding in its fragrance.The local flavor of this quintessence oil is warm fragrance, is with some burnt odor, Xin Xiang, but feeling of freshness and light Camphora flavor are arranged, and is bitter slightly.Because titrol has above-mentioned perfume (or spice) and flavor, in daily perfumery industry, it can be used for the fragrant GULONG water of men's suffering, aftershave lotion etc.It is mixed good with assorted clothes grass oil, Oleum lavandula angustifolia, compounding acetic isoborneol ester, Oleum Caryophylli, oil of rosemary, oak moss goods, cananga oil, amyl salicylate, coumarin, geraniol and the nerol etc. of smoking; Thereby use is comparatively convenient in perfumery, also is used to mingling of nutmeg oil and marjoram oil.

Australia produces about 500 tons of tea tree oil per year at present, almost all from tame Melaleuca Alternifolia.

3.1.2.5 production technology

Although the normal steam distillation that adopts on commercial production, other method for distilling also have its use value.In general no matter adopting steam distillation, hydrodistillation still is the solvent extraction of solvent extraction, microwave-assisted, for fresh or exsiccant Melaleuca Alternifolia branch and leaf raw material, the yield of quintessence oil does not have evident difference.The oil yield of solvent extraction (is solvent with ethanol) often is higher than steam distillation method (high 10-20%).The yield of monoterpene can improve 4-6%, and the yield of sesquiterpenoid improves more obvious.Because solvent extraction does not make essential oil component that bigger variation takes place, and more meet the composition situation of quintessence oil in the branch and leaf, thereby solvent extraction is usually used in the comparison and the screening (as being used for breed breeding) of plant variety.

3.1.2.6 main component

Be to the Meng-1-alcohol-4-1,8-cineole etc.For the raising that promotes oil quality with prevent to mingle the international standard that ISO/TC54 worked out tea tree oil in 1996.

The name of standard is called " Oil of Melaleuca terpinen-4-ol type "

Standard No.: ISO4730-1996;

Abnormal smells from the patient: a kind of colourless to flaxen liquid, have characteristic perfume;

Refraction index: n20D1.4750-1.4820;

Relative density: d20200.885-0.906;

Optically-active: (20C) be+5 °～+ 15 °;

Flash-point: about 56 ℃.

1 volume quintessence oil is dissolved in entirely≤2 volumes 85% (V/V) ethanol in, settled solution.Standard code 1; The content of 8-cineole is not more than 15% (capillary gas chromatography) and Foxlene-and the content of 1-alcohol is necessary >=30% (capillary gas chromatography), standard has also been stipulated (gas chromatographic analysis) bound of several kinds of representational characteristic chemical constituents of this quintessence oil.Be called " GCprofile ".These compositions are: (1.5%, 5%, the former is a minimum content to terpinolene, and the latter is high-load; 1.8-cineole (one, 15%) α-terpinene (5%, 13%) γ-Song Youxi (10%, 28%) cymene (0.5% down together); 12%) Foxlene-1-alcohol-4 (30%,-) alpha-terpineol (1.5%, 8%) limonene (0.5%, 4%) sabinene (trace; 3.5%) aromadendrene (Aromadedrene) (trace, 70%) 8-cadinene ((trace, 8%) Eucalyptus globulus Labill alkene (Globulol) (trace, 3%) viridiflorol (the Viridiforol) (trace of δ-cadinene); 1.5%) australene (1%, 6%) gas chromatographic analysis adopts OV-101 as immobile phase often, quartz capillary column length 50m; Internal diameter 0.2mm, column temperature rise to 220 ℃ from 70 ℃, and heating rate is 2 ℃/min.Though people know tea tree oil as the existing very long history of drug use, the research of it being made science starts from the '20s in last century.During World War II tea tree oil is issued the treatment that Australian soldier is used for skin damage.All research shows that all tea tree oil has disinfectant character, can suppress many ubiquitous pathogenic cells and mycete effectively.

3.1.2.7 application industry

We can think that it is a kind of natural disinfectant, have very great help for treatment numerous disease, wound.Like incised wound, scratch, by insect bite, acne, burn, vaginal infection, tinea etc.It also is used to control antibacterial and mycete in the air conditioning system.Present Australian tea tree oil is widely used in cosmetics, toilet articles and veterinary's articles for use.

This paper author is common tea tree oil to retail in Australian pharmacy and supermarket, and its concentration is about 15%, supplies consumer directly to make disinfectant and uses.Used and have the product of potential use value to have: agricultural fungicidal agent, sanitizer, antiseptic, air freshener, air-conditioning antibacterial, anti-acne (acne) cleansing cream, frost, water, bath with cleaning agent, automobile cleaning agent, carpet deodorizer, freshener, tableware cleaning agent, face usefulness, body and function, enough with cleaning agent, freshener, wetting agent, deodorizer, shampoo, house pet with hygienic article etc.In general to 100% tea tree oil, occur skin irritation ratio hypersensitive among the testee below 3.4%, be lower than 25% tea tree oil for concentration almost unmanned irritated.Cause that composition hypersensitive mainly is cymene and 1,4-peroxide Foxlene (ascaridole).

Tea tree oil stored the oxidation that causes oil for a long time with the improper meeting of storage, downgrade, and generation causes cymene hypersensitive and 1,4-peroxide Foxlene.Present Australian relevant department works energetically, and it is a kind of safe disinfectant that the relevant authoritative department of hoping U.S. FDA and other European countries is accepted tea tree oil.

Use the approval that obtains the U.S. already as for tea tree oil as food flavor, FEMA number is 3902.Its average degree of depth of using in bakery product, soft drink, alcoholic beverages, frumentum breakfast, cheese, chewing gum, confection, egg products, fish product, oils and fats, frozen dairy product, fruit product, instant coffee, tea, meat products, milk product, nut goods, cereal product etc. is 10ppm, and average maximum concentration is 30-50ppm.

3.1.2.8 Chinese tea tree oil

What also should specify here a bit is that present China and India are also producing tea tree oil; The major production areas of China is in Guangxi; Annual production is about tens of ton, is mainly used in outlet, but on the output far away from Australia; Oil qualitatively (mainly refer to 1, the 8-Folium eucalypti globueli (Eucalyptus globulus Labill.) mutually with Foxlene-1-alcohol-4) also too late Australian tea tree oil.Though the existing essence enterprise of China is used for perfumery with tea tree oil, just uses face wideless, thereby still be worth China relevant department to pay attention to the research and development of this quintessence oil.

3.1.2.9 tea tree oil research report

This kind of BMJ report quintessence oil was strong antibacterial of imitating in 1933; And explanation " this kind quintessence oil can not produce any infringement to organizing except that surprising sterilizing power, this point is not seen before; but because general antibacterial except killing bacteria, also can destroy normal structure "

Nineteen fifty-five, U.S.'s prescription handbook points out that the sterilizing ability of Camellia sinensis is phenolic 10-15 times.

1980, Australia was in harmonious proportion tea tree ethereal oil and water with 4: 1000 dilution ratio, checks its sterilizing ability, and after the regular hour, it can eliminate Candida albicans fully, high disease carrying germ such as staphylococcus.

Nineteen eighty-three; Australia combination food laboratory utilizes tea tree ethereal oil to carry out the skin degerming experiment, with the average on hand 50cm before not cleaning the antibacterial more than 3000 is arranged, and the number of bacteria of cleaning with distilled water is about 2000; After the tea tree ethereal oil cleaning, remaining less than 3!

Leipzig, Germany university experiment finds, Camellia sinensis can effectively be resisted 26 kinds of dermatophytes, 32 kinds of Candida albicans, and 22 kinds of little sporeformer.Research shows; Only need the concentration of tea tree ethereal oil 0.25% just can suppress 90% escherichia coli; Staphylococcus aureus also only needs 0.5%; The most attractive is to connect the superbacteria that various antibiotic have been developed immunity to drugs: anti-methicillinum property staphylococcus aureus, also can eliminate! Source: " fragrance flavor and cosmetic periodical ", third phase calendar year 2001.

3.1.3 salicylic acid: Chinese: salicylic acid, English name: salicylic acid; SA, other titles: oxybenzoic acid 3.1.3.1 definition:

The secondary metabolite of plant is generated or is generated through the side chain beta-oxidation by trans-cinnamic acid through hydroxylating by benzoic acid.Form with free state and glucoside in plant exists.Physiological regulatory action is arranged, like induced flowering and disease resistance etc.

3.1.3.2 affiliated subject:

Biochemistry and Molecular Biology (one-level subject); Hormone and vitamin (secondary subject)

3.1.3.3 master data

Salicylic acid; 2 hydroxybenzoic acid; 2-Hydroxybenzoic acid; Keralyt; Occlusal; Verrugon

Molecular formula C7H6O3

Structural formula C6H4 (OH) (COOH)

Molecular weight 138.12

CAS 69-72-7

Proportion 1.443

156 ℃～159 ℃ of fusing points

3.1.3.4 purposes

Salicylic acid is important fine chemical material.In medical industry, salicylic acid itself is exactly the extremely wide disinfection preservative of a kind of purposes.As medicine intermediate; It can be used for synthetic pressing down nitrogen sulfanilamide (Salazosulfanilamidum), Azudimidine (Salazosulfdimidine), antipyretic analgesic medicine aspirin (Aspirin), sodium salicylate (Natrii salicylas), salicylamide (Salicylamide), ethoxy acyl phenylamino (Ethoxybenzamidum), benorylate (Benorylatum), diflunisal (Diflunisal), salinaphtol (Salinaphtol), ethrisin (Salacetamide), lopirin (Lopirin), fenamifuril (Fenami furil), Saliphen (Saliphen), salicylamid-o-essigsaure (Salicylamid-o-Essigsaure), like ruvazone (Ruvazone), anilamate salicylic acid (Salicylic acid), be called B hydroxylic acid (BHA), the gentle skin fruit acid of B again.Salicylic acid has outstanding " exfoliation, unclogging " ability, and is safe, and lower than fruit acid to the stimulation effect of skin, thereby becomes the skin care products new lover.Effects such as it is aging that salicylic acid can desalinate pigmented spots, dwindles pore, remove tiny wrinkle and improve that Exposure to Sunlight causes.

3.1.3.5 the history of beauty treatment

The ad stream lang of often hearing recently similarly is: " old cutin has removed, and pore cannot see ", " I am exactly that way is returned in vain " etc. let the personage who likes to be beautiful go after like a flock of ducks.And be known as the leading role that can cause these miraculous effects is exactly salicylic acid.Though visit the gift of medium recently, everybody begins, and what's frequently heard can be repeated in detail to salicylic acid, and in fact salicylic acid is a kind of very senior dermatologic.Early stage salicylic acid is to be used for softening the medicine of sclerderm or dissolving cutin and improving looks and a bit pull not co-relation.

Albert M.Kligman doctor delivered on U.S.'s skin surgery medical journal in 1997; With the salicylic acid of 30% high concentration medicament as Chemical peeling; Can reach that to change skin identical with 70% fruit acid, desalination pigmented spots, the multinomial effect such as aging of dwindling pore, remove tiny wrinkle and improving that Exposure to Sunlight causes.Hereafter the salicylic acid reputation is made an uproar greatly, and cured fish stands up.

3.1.3.6 action principle

The metabolism of skin: the major function of keratodermatitis is to protect each confluent monolayer cells of skin, and the epidermis cell metabolism meeting of layer upon layer is passed naturally outward, after outermost horn cell is aging stiff gradually, under normal circumstances can consider to be worth doing naturally.The old cutin that does not normally come off can make skin seem to make skin metabolism speed slack-off in coarse dark Shen, even forms acne and block pore.

Salicylic acid can dissolve the formation shape material (cement) between cutin, horny layer is produced come off, and gathers blocked up horny layer so can remove, and enhances metabolism.

The effect of exfoliation: salicylic acid can be removed unnecessary horny layer, promotes the epidermis cell fast updating simultaneously; If when epidermis cell all is fresh full of vitality again young tender cell, just can let skin recover smooth careful naturally.

Dwindle pore: salicylic acid is fat-soluble, can infiltrate the deep layer of pore along the greasy sebaceous gland of secretion, help dissolving the horny layer of old accumulation in the pore, improves the situation that pore blocks, therefore the formation of acne capable of blocking and dwindle the pore that is stretched.

The prevention comedo: salicylic acid acts on the follicular wall cell; Can help to remove the hair follicle that is blocked and clogs, revise abnormal cell detachment, can prevent that to slight comedo pore from blocking; The most effective to blackhead; It can reduce the undesired obscission of follicular wall, prevents the generation of new focus, but not effect aspect minimizing sebum secretion and elimination Propiobacterium.Salicylic function is that the cleaning aging cutin makes skin seem comparatively careful, also relatively is not easy long acne.

3.1.3.7 superior characteristic

Fat-soluble, lowly stimulate, can go deep into pore.

The optimum selection responsive, that fat leaks the skin exfoliation:

Fruit acid AHA is a water solublity, and molecular weight is little, be easy to osmosis to epidermis than deep layer, or even in the skin corium.Fruit acid can directly influence the stratum basale cellular metabolism, also can impel skin corium collagen hypertrophy, and concentration is higher, and effect possibly heal fast the appearance, but the injury of relative property also possibly healed greatly.The liposoluble characteristic of salicylic acid BHA, molecular weight is also bigger, can not influence active epidermis cell with in the effect locking shallow-layer cutin.BHA is more superior aspect degree of stability, stimulation degree, makes user that less zest arranged, and similarly is twinge, sensation such as scorching hot.The chance that producing cumulative bad stimulates is also all lacked than fruit acid with the inflammation degree.

Remove acne, dwindle the sharp weapon of pore:

Salicylic acid also has many more superior speciality, and the ability of removing blackhead is exactly one of them.Because human keratinously contain abundant lipid, salicylic liposoluble characteristic can penetrate into horny layer and pore depths by the mode that merges with lipid, but can not cause stimulation to dermal tissue.Be difficult to stop for a long time in the pore compared to fruit acid itself, limit to some extent, want to treat pore acne problem and don't, needing extreme care and accurately aspect the concentration of using fruit acid and time as for skin ambustion for the sebum of thorough Peppermint Extract accumulated.

Fruit acid can unimpeded pore, and reason is just as opening bottle cap, and salicylic acid can be further the waste scavenging in the bottle.Sebum and the cutin of containing gathered in the BHA cleaning in pore, help attenuating and cause the comedo probability because of hair follicle blocks inflammation.

3.1.3.8 salicylic concentration

It is very wide that salicylic acid uses, and eczema, chronic eczema, comedo, dandruff all possibly used salicylic acid, and concentration can be used for exfoliation at the salicylic acid of 3-6%, and being higher than 6% has destructiveness to tissue.40% concentration is suitable for treating clavus, thick cocoon, viral verruca with next.Salicylic acid also can be added in the medicine of treatment comedo and dandruff.At present many well-known cosmetics add the salicylic acid compositions, and Clinique CLINIQUE at first released the gentle renewal blushing that contains 1% salicylic acid composition in 1993, become one of successful product of Clinique at once.The SK-II crystalline substance caused skin-changing cream in 1998, in original Pitera prescription, added the 1.5%BHA composition, and handled the upsurge in the effect initiation market of pore and cutin with the metaphor salicylic acid of the egg of peeling off.The Lamasia hot product skin-active essence frost of open-shelf path also contains the 1.5%BHA composition.

3.1.3.9 salicylic side effect

Because the acid of high concentration bigcatkin willow has certain nocuity; Played Department of Health's pharmaceutical control and administration place salicylic acid concentration limit that cosmetics are contained in 1999 between 0.2-1.5%; Contain the bigcatkin willow acidify and make up of the safety of article palpus filling poster, and the child below 3 years old also must not use with definite life-time service.

● local action: excessively remove horny layer, erythema, pruritus, twinge or allergic phenomena possibly take place in the phylactic power defensive power meeting variation of skin, so use salicylic acid need strengthen the reparation of preserving moisture, preferably avoid contact eye, face, genitals and mucosa.Also there are a few peoples can take place, the just unsuitable salicylic acid that uses any concentration to salicylic acid symptom hypersensitive.

● General Symptoms: for general skin care, a small amount of user, should the unlikely side effect that has general.But (greater than whole body area 30%) or the salicylic patient of life-time service must pay special attention to the generation of salicylism (Salicylism) effect on a large scale.Comprise tinnitus, dizzy, asthenia occurring, feeling sick and situation such as electrolyte disturbance that these symptoms especially take place the patient of child and kidney, hepatic insufficiency more easily, as if salicylic acid toxicity, drug withdrawal immediately occurring.

3.1.3.10 points for attention

Exfoliation skin care products on the market is of a great variety, similarly is A acid, A pure (aldehyde), fruit acid, salicylic acid even azelaic acid, and the effect of exfoliation, promotion skin metabolism is all arranged, and the product of these exfoliations cannot use at one time.Fragile or the situation hypersensitive when skin, similarly be tan severely, phenomenons such as pruritus, twinge, decortication, just be not suitable for using the product of salicylic acid, can cause overstimulation or burn.

Exfoliation can cause the protection of epidermis cell to descend, so will pay attention to more preserving moisture and sun-proof use.Responsive, fat leakage property skin has the demand of exfoliation, preferably selects more not irritating salicylic acid of tool or lactone type gluconic acid, more can not cause the burden of skin.

3.1.3.11 store

Stable in the air, meet light variable color gradually.Should be stored in cool place, ventilation, the exsiccant storehouse, keep fire away, thermal source, separate with explosive material, oxidant and deposit.These article ability chafe, mucosa also can react with the protein in the body tissue, and corrosiveness is arranged.Take symptoms such as causing vomiting, suffer from diarrhoea, suffer from abdominal pain, breathe frequency is short, acidosis in a large number.

3.1.4 citric acid:

Chinese: citric acid

English name: citric acid

Chinese 2:2-hydroxy propane-1,2, the 3-tricarboxylic acids

English name 2:2-hydroxy-1,2,3-propanetricarboxylic acid

CAS?No.：77-92-9

Molecular formula: C6H8O7

Molecular weight: 192.14

Outward appearance and character: white crystalline powder, odorless.

Fusing point (℃): 153

Boiling point (℃): (decomposition)

Relative density (water=1): 1.6650

Flash-point (℃): 100

Ignition temperature (℃): 1010 (powder)

UEL % (V/V): 8.0 (65 ℃)

Dissociation constant (25 ℃): Ka1=7.4 * 10^-4, Ka2=1.7 * 10^-5, Ka3=4.0 * 10^-7

Dissolubility: water-soluble, ethanol, acetone, be insoluble to ether, benzene, be slightly soluble in chloroform.It is acid that aqueous solution shows.Physical property: at room temperature, citric acid is colourless translucent crystal or white particle or white crystalline powder, the extremely acid of odorless, flavor, and little in malaria have a hygroscopy.It can exist with the form of no hydrate or monohydrate: citric acid during crystallization, generates no hydrate from hot water; Crystallization then generates monohydrate in cold water.Monohydrate can decompose and obtains not having hydrate when being heated to 78 ℃.In the time of 15 degrees centigrade, citric acid also can dissolve in dehydrated alcohol.The citric acid crystal habit is different different because of crystallization condition, the citric acid 2C6H8O7.H2O, C6H8O7.H2O or the C6H8O7.2H2O that have anhydrous citric acid C6H8O7 also to have to contain water of crystallization.

3.1.4.1 chemical property: say that from structure citric acid is a kind of tricarboxylic acids compounds, and therefore similar physics and chemical property are arranged with other carboxylic acids.It can decompose generation carbon dioxide and water when being heated to 175 ℃, remains some white crystals.Citric acid is a kind of stronger organic acid, has 3 H+ can ionization; Heating can be resolved into multiple product, reacts with acid, alkali, glycerol etc.

3.1.4.2 natural existence

Natural lemon acid distributes very wide at occurring in nature, natural citric acid is present in the skeleton, muscle, blood of fruit such as plant such as Fructus Citri Limoniae, Citrus, Fructus Ananadis comosi and animal.The citric acid of synthetic contains sugar substance fermentation with Saccharum Sinensis Roxb., molasses, starch, Fructus Vitis viniferae etc. and makes, and can be divided into anhydrous and two kinds of hydrates.Pure article citric acid is water white transparency crystallization or white powder, and odorless has a kind of tempting tart flavour.

Contain all in the fruit of a variety of fruits and vegetables, especially Citrus that more citric acid, particularly Fructus Citri Limoniae and blue or green lemon--they contain a large amount of citric acids, after drying, content can reach 8% (content in fruit juice is approximately 47g/L [3]).In citrus fruit, the content of citric acid is between the 0.30mol/L of the 0.005mol/L of orange and Fructus Vitis viniferae and Fructus Citri Limoniae and blue or green lemon.This content changes along with the growing state of different cultivated kind and plant to some extent.

3.1.4.3 tricarboxylic acid cycle

Have another name called: tricarboxylic acid cycle

Citric acid is among the physiology fat, protein and sugar to be converted into the important compound in the process of carbon dioxide.These chemical reactions are nearly all metabolic core reactions, and energy are provided for higher organism.This Adaofu's kerbs of the Chinese has obtained nineteen fifty-three Nobel physiology or medical science prize because find this series reaction.This series reaction is called " tricarboxylic acid cycle ", " tricarboxylic acid cycle " or " Ke Shi circulation ".

3.1.4.4 produce brief history

The C.W. house was reined in and at first from Citrus, is extracted citric acid in 1784.He produces citric acid through in fruit is squeezed the juice, adding lime cream to form the sedimentary method of calcium citrate.California, USA, Italy and the West Indies are originated in natural lemon acid at first.Gondola output ranks first.To nineteen twenty-two, the total sales volume of world's citric acid 90% by monopolizations such as the U.S., Britain, France.Fermentation method is produced citric acid and was started from for 19 end of the centurys.C. Wei Gadamer in 1893 finds that penicillium sp (genus) bacterium can accumulate citric acid.B. Zha Huosiji report aspergillus niger can generate citric acid in 1913.Tom in 1916 and curry make an experiment with the aspergillus bacterium, confirm that most of aspergillosiss such as aspergillus awamori, aspergillus oryzae, Wen Shi aspergillosis, Trichoderma viride and aspergillus niger all have the ability of producing citric acid, and the acid producing ability of aspergillus niger are stronger.Like curry is strains tested with the aspergillus niger, in 15% sucrose culture fluid, ferments, and the absorbance of sugar is reached 55%.Nineteen twenty-three U.S. Fei Ze company has built first hand is in the world produced citric acid with aspergillus niger shallow tray fermentation method factory.Belgium, Britain, Germany, the Soviet Union etc. study successful fermentative Production citric acid in succession subsequently.Like this, rely on the method for from Citrus, extracting natural lemon acid to be replaced by citric acid fermented gradually.Before nineteen fifty, citric acid adopts the shallow tray fermentation method to produce.Nineteen fifty-two, this test chamber of U.S.'s mayer adopted tank fermentation method large-scale production citric acid.After this, tank fermentation method is set up gradually.The submerged fermentation cycle is short, and productive rate is high, saves the labour force, and floor space is little, is convenient to realize instrument control and serialization, has become citric acid 3.1. at present

4.5 the main method of producing.

In the national expenditures fermentation method produce citric acid and be reported as the earliest with nineteen forty-two Tang Tenghan etc.Nineteen fifty-two Chen Sheng etc. begins to produce citric acid with the aspergillus niger shallow tray fermentation.Fermentation industry Science Institute of Ministry of Light Industry has accomplished 2001 scale submerged fermentation system IMViC tests in nineteen fifty-nine, and nineteen sixty-five has carried out producing the intermediate experiment that 100t beet molasses raw material shallow tray fermentation is produced citric acid, and puts into production in nineteen sixty-eight.After 1966; Tianjin Research Institute of Industrial Microbiology, Shanghai City Industry Wei Biological Research Institute are carried out the experimental study of carrying out potato dry powder raw material submerged fermentation citric acid with aspergillus niger in succession; And succeed, thereby confirmed this main technique route that Meyer lemon acid is produced.Potato dry powder submerged fermentation citric acid, abundant raw material, technology is simple, need not add nutritive salt, and productive rate is high, is the unique advanced technologies of China.

The citric acid fermented research of CNPC starts to walk early.1970, ground research units such as Tianjin, Shanghai, Shenyang, Changzhou utilized Candida lipolytica (candida lipolytica) to carry out the test of liquid paraffin (n-alkane) fermentation production of citric acid.Xu Zi deep pools in 1979 etc. filter out the strain variant Candida lipolytica responsive to Fluoroethanoic acid, and the activity of its aconitate hydratase is very low, and the generation ratio of citric acid is increased to 80% from original 50%, thereby has improved the productive rate of petro-jelly fermentation citric acid.

Along with the progress of biotechnology, citric acid industry has had the development of advancing by leaps and bounds, and whole world citric acid output has reached 0.4Mt.In the citric acid fermentation technical field, because the application of superior strain and the continuous developing of new technique, citric acid fermentation and extract yield all are significantly improved, and every production 1t citric acid consumes 2.5～2.8t molasses respectively, 2.2～2.3t potato dry powder or 1.2～1.3t sucrose.People are developing immobilized cell circulating biological reaction vessel fermentation technique energetically

3.1.4.6 main uses

Citric acid is first acid in the organic acid, because the performance of physical property, chemical property, derivant is to be widely used in the most important organic acid of industry such as food, medicine, daily use chemicals.

4. useful effect

4.1 many patients with acne, after medication a period of time, acne has been eliminated really, but pox speckle, pox seal is retained on the face for a long time, and the beautiful appearance of patient is exerted a certain influence.The formation of pox speckle, pox seal: 1. patients with acne affected part blood circulation is obstructed, and capillary rupture or blood capillary stop up and the punctation or the marking that cause; 2. patients with acne illing skin tissue damaged causes the skin care barrier to be destroyed, damaged skin generation stress; Impel skin to produce melanin; To protect skin to avoid the injury of extraneous (ultraviolet), in a single day melanin deposits, just formed the tangible marking.3. above often two kinds of situation exist simultaneously, are interweaved, and as effectively not treating, the pox seal will be difficult to automatic removing.

4.2 in the product for resolving poxes and prior art of list marketing now, the treatment acne mainly with antiinflammatory, antibacterial, to improve pox property skin be therapeutic purposes.With prior art be example: patent name: a kind of compositions with acne-removal function.Country origin: China, number of patent application: 200810073731.3, a kind of compositions with acne-removal function is mainly processed by following weight portion raw material: Herba Rosmarini Officinalis 0.5～10, Folium Pini 0.5～10.Also can add Oleum lavandula angustifolia, the natural anti-acne composition of Camellia sinensis wet goods simultaneously, and/or chemical anti-acne composition such as vitamin B6, allantoin.Said composition can add medicine or cosmetics acceptable auxiliary, processes medicine or cosmetics, can effectively suppress the epidermis fat secretion, suppresses the acne growth, and the redness that disappears is killed the acne bacillus, and the anti-acne determined curative effect is safeguarded skin health.And needed raw material source is wide, production cost is low, safely, have no side effect.

4.2.1 the technical specification contrast: number of patent application is 200810073731.3 patented technology; Form by natural anti-acne composition tea tree oil, Oleum lavandula angustifolia and chemical anti-acne composition vitamin B6, allantoin etc.; Main effect is to suppress the epidermis fat secretion, suppresses the acne growth, and redness disappears; Kill the acne bacillus, and ignored treatment pox speckle, pox seal; And the present invention according to Chinese medicine dialectical execute control, wholistic therapy is guideline, adopting natural plant essential oils Rosehips oil, tea tree oil and the acid of chemical medicinal liquid poplar, citric acid is primary raw material, adds the processing of a certain amount of adjuvant or substrate and the product that comes.Identical point with the contrast technology: tea tree oil is the raw material in the prescription.Compare disruptive technology of the present invention with the contrast technology: adopt Rosehips oil 60g-80g, tea tree ethereal oil 20g-50g; Salicylic acid 5g-10g, citric acid 3g-6g adds the processing of appropriate amount of auxiliary materials or substrate and next product; The present invention not only has treatment comedo, skin sore, acne; And can effectively dispel pox speckle, pox seal, and quicken skin metabolism, make skin bright and clean, bright.Tea tree oil antiinflammatory among the present invention, antibacterial; Peppermint Extract, Rosehips oil are whitened, skin moistening, reparation damaged skin, in conjunction with salicylic acid, citric acid exfoliation; Quicken the effect of skin metabolism; Each component synergism produces whole therapeutic effect, thereby has realized dispeling the effect of acne, pox seal.In the present invention, use the effect that anti-acne, pox are printed that produced after tea tree oil, Rosehips oil, salicylic acid and citric acid mix.

4.2 clinical testing data

4.2.1 do the clinic trial test with the present invention; Select 30 patients for use, 15 routine male patients wherein, 15 routine female patients are object on probation; Cycle on probation is 30 days (remarks: rehabilitation is not just in medication in 30 days), and experimental condition is: respectively smear once product of the present invention every day sooner or later.Statistics clinic trial result, untoward reaction and toxic and side effects.The clinic trial evaluation criterion: be applied in the affected part with the present invention, thoroughly dispel acne, pox speckle, pox seal, the result is a determined curative effect, fully recovers; If only dispel acne, do not dispel pox speckle, pox seal, the result is for producing effect, but do not fully recover.

1. model Rong Mei, woman, 27 years old, disease sites: cheek and forehead.Clinical symptoms: red, swollen, bitterly, hoary hair's acne; Use every day product of the present invention sooner or later after twice, three day hoary hair's acne come off, use and calm down the pox body after 15 days basically; Use 25 days left and right sides pox seals to disappear.

2. the hole fine jade is flourish, and the woman 33 years old, suffers from the pox position: around the lip.Clinical symptoms: long throughout the year pox, red, swollen, tuberosity.Use product of the present invention every day 2 times sooner or later, the pox body diminishes after 2-3 days, uses after 30 days the still lasting long pox around the affected part, recovery from illness.

3. the hole is natural, and the man 27 years old, suffers from the pox position: forehead, cheek.Clinical symptoms: red, swollen, bitterly, the pox body is big.Use product of the present invention every day 2 times sooner or later, that medication was eliminated after 3 days is red, bitterly, and the pox body diminished in 7 days, left and right sides pox seal disappearance in 15 days.

4. Gao Jinmei, the woman 24 years old, suffers from the pox position: forehead, cheek.Clinical symptoms: the pox body is little, is the blister shape, and is little red.Use product of the present invention every day 2 times, medication is eliminated red after 3 days, and the pox body diminished in 7 days, calms down the pox body about 15 days, and the pox seal was eliminated in 25 days.

5. Liu Li, the woman 21 years old, suffers from the pox position: forehead, cheek.Clinical symptoms: red, swollen, the pox body is intensive.Use product of the present invention every day 2 times, medication after 5 days the pox body diminish, left and right sides small pox obviously reduced in 20 days, the complete obiteration of 30 days left and right sides pox seals.

6. Wen Xinqi, the man 22 years old, suffers from the pox position: forehead.Clinical symptoms: the pox body is bigger, and is red, swollen, bitterly.Use product of the present invention every day 2 times, medication after 3 days the pox body diminish, the pox body calms down after 15 days, pox seal disappears after 25 days.

7. Liu Jia, woman, 18 years old, disease sites: cheek.Clinical symptoms: the pox body is small and dense, and color and luster is red.Use product of the present invention every day 2 times, medication after 15 days the pox body obviously diminish, the pox body calmed down fully in 25 days, pox seal disappears after 30 days.

8. Zhang Xiaoping, woman, 37 years old, disease sites: cheek, forehead.Clinical symptoms: the pox body is big, red, swollen, tuberosity.Use product of the present invention every day 2 times, medication after 5 days pain disappear, the pox body obviously diminishes, 10 days posterior tubercles of medication diminish, part pox body comes off, on the face small pox has been calmed down small pox recovery from illness after 25 days, the complete obiteration of pox seal basically after 15 days.

9. in the positive spring of Liu, the man 21 years old, suffers from the pox position: forehead.Clinical symptoms: the pox body is little, intensive, and is red, swollen.Use product of the present invention every day 2 times, use 10 days rear section small poxs obviously to reduce, return to one's perfect health about 20 days, the pox seal is basic to disappear.

10. Yuan Xiang, the man, 32 years old, suffer from the pox position: cheek, the pox body disperses, and is red, swollen.Use product of the present invention every day 2 times, 3 days rear sections of medication pox soma is flat, come off, and the pox body calms down fully after 10 days, and the pox seal is basic after 15 days disappears.

11. Pan Liming, the man 35 years old, suffers from the pox position: cheek.Clinical symptoms: the pox body is red, swollen, pustule, tuberosity, uses product of the present invention every day 2 times, uses 30 days, and the pox body does not have significant change.

12. open China, the woman 16 years old, suffers from the pox position: cheek, forehead.Clinical symptoms: the pox body is little, rare, and is little red.Use product of the present invention every day 2 times, medication after 2 days the pox body obviously diminish, medication after 5 days small pox quantity obviously reduce.Small pox is calmed down basically after 10 days, and the pox seal disappears.

Bright and beautiful 13. end, the woman 18 years old, suffers from the pox position: forehead.Clinical symptoms: the pox body is less, and is intensive.Use product of the present invention every day 2 times, medication after 3 days small pox obviously reduce, left and right sides small pox was calmed down fully in 5 days, 10 days basic disappearances of left and right sides pox seal.

14. king Qu Ling, the man 26 years old, suffers from the pox position: cheek.Clinical symptoms: the pox body is big, and is red, swollen, bitterly.Use product of the present invention every day 2 times, medication after 5 days the pox body begin micro, diminish, the pox body begins to come off after 10 days, left and right sides pox body calmed down basically in 20 days, 30 days basic disappearances of left and right sides pox seal.

15. stone is built, the man, and 29 years old, suffer from the pox position: face was uneven distribution.Clinical symptoms: the pox body is big, red, swell, touch pain.Use product of the present invention every day 2 times, medication after 10 days the pox body obviously diminish, redness goes down, 15 days left and right sides of medication pox body begins to come off, left and right sides pox body calmed down in 20 days, 25 days poxes seal is basic to disappear.

16. Marvin's is flat, the man 24 years old, suffers from the pox position: cheek.Clinical symptoms: the pox body is big, and is red, swollen, bitterly.Use product of the present invention every day 2 times, medication is red and swollen the disappearance after 10 days, after 15 days the pox body begin shrivelled, come off, use these article to take an evident turn for the better in 30 days, but do not fully recover.

Feng 17. hang down in the hole, the man, 30 years old, suffer from the pox position: wing of nose both sides, near the lip.Clinical symptoms: the pox body is red, swell, have the hoary hair.Use product of the present invention every day 2 times, medication 3 days left and right sides hoary hairs come off, and calms down the pox body about 10 days basically, left and right sides pox seal complete obiteration in 20 days.

18. Wang Ziming, the man, 38 years old, suffer from the pox position: face was irregular distribution, and the pox body is big, and quantity is many, and is red, swollen.Use product of the present invention every day 2 times, 15 days left and right sides of medication pox soma is flat, come off.Left and right sides small pox was calmed down basically in 30 days, and the pox seal is basic to disappear.

19. Wang Xiao is magnificent, the woman 23 years old, suffers from the pox position: around the lip and wing of nose both sides.Clinical symptoms: the pox body is little, and is red, swollen.Use product of the present invention every day 2 times, medication after 3 days the pox body diminish, 10 days left and right sides pox somas are flat, come off 15 days basic disappearances of left and right sides pox seal.

20. Liu Xing, the woman 19 years old, suffers from the pox position: cheek.Clinical symptoms: the pox body is little and many.Use product of the present invention every day 2 times, medication after 3 days small pox obviously tail off, medication after 10 days small pox disappear basically, 15 days poxes seal disappears.

21. open nanmu, the woman 15 years old, suffers from the pox position: cheek, forehead.Clinical symptoms: red, swollen.Use product of the present invention every day 2 times, medication after 5 days the pox body obviously diminish, medication after 10 days small pox disappear basically, pox seal in the left and right sides disappeared in 20 days.

22. Chen Ming is expensive, the man 42 years old, suffers from the pox position: cheek.Clinical symptoms: red and swollen, tuberosity.Use product of the present invention every day 2 times, medication after 5 days red and swollen symptom alleviate to some extent, 15 days posterior tubercles of medication diminish, and have part pox soma flat, come off, medication after 30 days small pox still the recovery from illness.

23. Yang Yu, woman 21 years old, suffer from the pox position: face is irregular distribution.Clinical symptoms: the pox body is small and dense.Use product of the present invention every day 2 times, medication after 5 days small pox obviously reduce, left and right sides small pox was calmed down in 15 days, pox seal complete obiteration after 20 days.

24. it is clear to open celebrating, the man 37 years old, suffers from the pox position: around the lip.Clinical symptoms: the pox body is big, few, red, swollen, bitterly.Use product of the present invention every day 2 times, medication after 3 days the pox body diminish, pain disappears, 10 days left and right sides of medication pox body comes off, left and right sides pox seal disappeared in 15 days.

25. Liu German side, the man 33 years old, suffers from the pox position: cheek.Clinical symptoms: red, swollen, tuberosity.Use product of the present invention every day 2 times, medication after 5 days the pox body obviously diminish, that 15 days left and right sides pox bodies begin is shrivelled, come off, left and right sides pox body calmed down basically in 20 days, the pox seal is basic to disappear.

26. Wang Ji, the man 19 years old, suffers from the pox position: cheek.Clinical symptoms: red, swollen, bitterly.Use product of the present invention every day 2 times, medication after 5 days the pox body diminish, rear section pox body came off in 10 days, small pox was calmed down fully in 20 days, pox seal disappears.

27. the river fine jade, the woman 22 years old, suffers from the pox position: forehead.Clinical symptoms: the pox body is close and many.Use product of the present invention every day 2 times, medication after 5 days small pox obviously reduce, left and right sides small pox disappeared basically in 8 days, 15 days basic disappearances of left and right sides pox seal.

28. old Bao Jiang, the man 35 years old, suffers from the pox position: cheek, forehead.Clinical symptoms: redness, the pox body is big.Use product of the present invention every day 2 times, medication after 3 days the pox body begin micro, the pox body begins to come off after 10 days, small pox is calmed down basically after 15 days, 20 days poxes seal disappears.

29. Li Fei is luxuriant and rich with fragrance, the woman 16 years old, suffers from the pox position: cheek, forehead.Clinical symptoms: the pox body is red, swollen.Use product of the present invention every day 2 times, medication after 2 days the pox body obviously diminish, redness improves, the pox body smooths basically after 7 days, 15 days poxes seal disappears.30. open red mist, the woman 30 years old, suffers from the pox position: near the lip.Clinical symptoms: the pox body is red, swollen, big.Use product of the present invention every day 2 times, medication after 1 day the pox body obviously diminish, small pox is calmed down basically after 7 days, medication after 15 days pox seal disappear.

3.2.2 case statistics and analysis

Clinical statistics: clinic trial patient is the 30 routine patients with acne in 15-42 year, 15 women, and 15 male, patient every day is smeared the present invention in the affected part twice sooner or later, and wherein 29 people use these article produce effects afterwards, and 1 people does not have positive effect, and total effective rate is 96.6%; 26 people cured in 30 days to not having pox speckle, pox seal, and 4 people do not fully recover, and its cure rate is 86.6%.Have 2 people in 10 days, to fully recover, 8 people fully recovered in 15 days, and 7 people fully recovered in 20 days, and 5 people fully recovered in 25 days, and 4 people fully recovered in 30 days.This shows: the present invention is reliable for effect to remedy of acne, effect is remarkable.

3.2.3 untoward reaction: in 30 cases of this clinic trial, it is 10 days that the patient uses the shortest time of the present invention, and maximum duration is 30 days, and all not finding after the medication has the symptom of untoward reaction to occur.

3.2.4 toxic and side effects: in 30 cases of this clinic trial, it is 10 days that the patient uses the shortest time of the present invention, and maximum duration is 30 days, does not all have toxic and side effects after the medication.

4. the specific embodiment

4.1 prescription design: acne is because a kind of dermatosis that hair follicle and sebaceous gland are blocked, inflammation caused.Execute according to differential diagnosis in tcm control, the guideline of wholistic therapy; The present invention's utilization has the combination of effect medicines such as anti-inflammation and sterilization, unclogging, whitening and skin-protecting, acceleration skin metabolism and uses; Each component synergism; Produce whole therapeutic effect, thereby realized dispeling the effect of acne, pox speckle, pox seal.It is primary raw material that the present invention adopts natural plant essential oils Rosehips oil, tea tree oil and chemical medicine citric acid, salicylic acid, adds the product for resolving poxes that appropriate amount of auxiliary materials is processed.

4.2 in prescription design of the present invention; The effect of Propiobacterium is killed in the tea tree oil performance, and Rosehips oil is brought into play the skin-active of whitening, the effect of desalination mottle; Aging cutin is dispeled in salicylic acid, citric acid performance; Promote the effect of skin metabolism, the multiple-effect unification, thus reach the purpose of treating acne, pox seal.

4.2.1 Rosehips oil consumption design: Rosehips oil has the enhanced tissue function, and penetration is strong, pair cell regeneration, repairs and healing has splendid effect, can desalinate cutaneous pigmentation, impels that skin is smooth whitens, and reappears the even color and luster of skin.Skin uses no obvious adverse reaction and toxic and side effects behind the Rosehips oil, and the working concentration of Rosehips oil can be 100% concentration, generally 10% with interior just effective; The strong quality of Rosehips oil and special rich nutrient contents; Skin matter for oiliness skin and long pox; Use the concentration of Rosehips oil preferably to be no more than 10%; When the prescription design, consider the effectiveness and the suitability of medicine, so Rosehips oil consumption lower limit when prescription designs is designed to 6%, the consumption upper limit is designed to 8%.

4.2.2 tea tree oil consumption design: tea tree oil is nontoxic, have no side effect, and can also can not damage human body with 100% concentration.Water is diluted to 15% concentration with tea tree ethereal oil, can directly use as disinfectant; Nineteen fifty-five, U.S.'s prescription handbook points out that the sterilizing ability of Camellia sinensis is phenolic 10-15 times; 1980, Australia was in harmonious proportion tea tree ethereal oil and water with 4: 1000 dilution ratio, checks its sterilizing ability, and after the regular hour, it can eliminate Candida albicans fully, high disease carrying germ such as staphylococcus.In when design prescription, have certain bactericidal action in order to guarantee the present invention, so prescription is limited to 2% under designing, but considers that the tea tree oil consumption is excessive and be not easy to process certain dosage form, so recipe quantity is designed to be limited to 5%.

4.2.3 salicylic acid consumption design:, played Department of Health's pharmaceutical control and administration place salicylic acid concentration limit that cosmetics are contained between 0.2-1.5% in 1999 because the acid of high concentration bigcatkin willow has certain nocuity.When the prescription design, for guaranteeing reliable curative effect of the present invention, so the recipe quantity lower limit is designed to 0.5%; Guarantee drug safety of the present invention, the recipe quantity upper limit is designed to 1.0%, thereby reach the organic unity of curative effect and safety.

4.2.4 citric acid consumption design: in the present invention, utilize the auxiliary salicylic acid of acidity effect of citric acid to dispel cutin, quicken skin metabolism, make skin bright, glossy.Thereby reduce heavy dose of use salicylic acid and cause the injury that human body is caused.In when design prescription, consider that citric acid mainly plays auxiliary salicylic effect in the present invention, consumption is unsuitable excessive, does not also have certain assosting effect but consumption is too little, is 0.3% so its use amount is designed to the lower limit consumption, and maximum amount is 0.6%.4.3 prescription proportioning: Rosehips oil 60g-80g, tea tree ethereal oil 20g-50g, salicylic acid 5g-10g, citric acid 3g-6g adds the product that an amount of substrate or adjuvant are processed 1000g.

4.4 method for preparing: measure Rosehips oil, tea tree oil, salicylic acid, citric acid by prescription, add the product that makes 1000g behind an amount of substrate or the adjuvant mix homogeneously.

4.5 method for using: get an amount of facial milk cleanser and be applied to the affected part, massage is gently cleaned with clear water, dries moisture, and it is an amount of to get the present invention, is applied in the affected part gently, massages about 10 seconds, gets final product.Sooner or later each uses once in the present invention.

4.5 therapeutic efficiency: these article have treatment comedo, skin sore, acne, and can quicken skin metabolism, effectively dispel pox speckle, pox seal, make skin bright and clean, bright.

4.6 attention: these article use and to be limited to skin surface unexpectedly, are not taken orally, eye.As pleasing to the eye accidentally, please use flushing with clean water immediately.

Claims (10)

1. One kind can anti-acne, the compositions of anti-acne seal; With natural plant essential oils tea tree oil (this characteristic is this invention and the total essential features of immediate prior art), Rosehips oil and the acid of chemical medicinal liquid poplar, citric acid is primary raw material, adds the processing of a certain amount of adjuvant or substrate and next product.It is characterized in that Rosehips oil: 60g-80g, tea tree ethereal oil: 20g-50g, salicylic acid: 5g-10g, citric acid 3g-6g adds the product (this characteristic is the technical characterictic that this invention is different from prior art) that makes 1000g behind an amount of substrate or the adjuvant mix homogeneously.
2. 2. compositions that can anti-acne according to claim 1 is characterized in that: by using the effect with anti-acne behind tea tree oil, Rosehips oil, salicylic acid and the citric acid mix homogeneously.
3. 3. according to claim 1 can anti-acne the compositions of seal, it is characterized in that: by using effect behind tea tree oil, Rosehips oil, salicylic acid and the citric acid mix homogeneously with anti-acne seal.
4. 4. according to claim 1 can anti-acne the compositions of seal, it is characterized in that: by the lotion agent that makes behind tea tree oil, Rosehips oil, salicylic acid and the citric acid mix homogeneously.
5. 5. according to claim 1 can anti-acne the compositions of seal, it is characterized in that: by the ointment that makes behind tea tree oil, Rosehips oil, salicylic acid and the citric acid mix homogeneously.
6. 6. according to claim 1 can anti-acne the compositions of seal, it is characterized in that: by the liniment that makes behind tea tree oil, Rosehips oil, salicylic acid and the citric acid mix homogeneously.
7. 7. according to claim 1 can anti-acne the compositions of seal, it is characterized in that: by the medicated wine that makes behind tea tree oil, Rosehips oil, salicylic acid and the citric acid mix homogeneously.
8. 8. according to claim 1 can anti-acne the compositions of seal, it is characterized in that: by the tincture that makes behind tea tree oil, Rosehips oil, salicylic acid and the citric acid mix homogeneously.
9. 9. according to claim 1 can anti-acne the compositions of seal, it is characterized in that: by the gel that makes behind tea tree oil, Rosehips oil, salicylic acid and the citric acid mix homogeneously.
10. 10. according to claim 1 can anti-acne the compositions of seal, it is characterized in that: by the liniment that makes behind tea tree oil, Rosehips oil, salicylic acid and the citric acid mix homogeneously.