CN102266277A - Application of callicarpa nudiflora extract in daily chemical cleaning products - Google Patents
Application of callicarpa nudiflora extract in daily chemical cleaning products Download PDFInfo
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Abstract
The invention provides application of callicarpa nudiflora extract in daily chemical cleaning products. In the application, the callicarpa nudiflora extract is added into hand sanitizer, soap, foot cleaning fluid, bath foam and cleanser series daily chemical cleaning products. The prepared callicarpa nudiflora series daily chemical cleaning products are safe, and have unique effect.
Description
Technical field
The present invention relates to the application of Callicarpa nudiflora extract in the daily use chemicals cleaning product, in particular, the present invention relates to the application of Callicarpa nudiflora extract in handwashing liquid, soap, foot lotion, bath foam, liquid detergent series daily use chemicals cleaning product.
Background technology
Callicarpa nudiflora (CallicarpanudifloraHook.exArn.) is Verenaceae (Verbenaceae) Callicarpa plant, and main product is a kind of Hainan authentic medicinal herbs in China Hainan, and also there is distribution in China Guangdong, Guangxi.
That Callicarpa nudiflora has is antibacterial, hemostasis, analgesia, Thyme Extract, the applicant has done a lot of researchs to the chemical constituent of Callicarpa nudiflora, and further further investigate by technology to Callicarpa nudiflora, thereby provide a kind of active component content higher, have good bactericidal effect, have the potential quality that well is developed to pure natural daily use chemicals cleaning product.Never there is report that Callicarpa nudiflora is applied in handwashing liquid, soap, foot lotion, bath foam, the liquid detergent series daily use chemicals cleaning product at present, has fabulous research and development and market prospect in this field as the Callicarpa nudiflora of genuine multitude's medicine.
Summary of the invention
[0003] the purpose of this invention is to provide the application of a kind of Callicarpa nudiflora extract in the daily use chemicals cleaning product.With Callicarpa nudiflora extract, add in handwashing liquid, soap, foot lotion, bath foam, the liquid detergent series daily use chemicals cleaning product.
(1) preparation of Callicarpa nudiflora extract
Callicarpa nudiflora extract of the present invention is water, alcohol or the diluted ketone extraction thing of fresh or dry Callicarpa nudiflora raw material.
Callicarpa nudiflora extract of the present invention prepares by following any method:
(1) adopt the fresh or dried feed of Callicarpa nudiflora, add entry or rare alcohol or rare ketone solvent, heating extraction, extracting solution filters, and filtrate concentrates, the dry Callicarpa nudiflora extract A that gets;
(2) adopt the fresh or dried feed of Callicarpa nudiflora, add entry or rare alcohol or rare ketone solvent, heating extraction, extracting solution filters, and filtrate is passed through macroporous adsorbent resin column chromatography, wash cylinder with water, discard water lotion, reuse 10%～90% ethanol elution, eluent filters, concentrate the dry Callicarpa nudiflora extract B that gets;
(3) the Callicarpa nudiflora raw material of fresh state obtains pressed liquor and press residue through squeezing, and pressed liquor filters, and filtrate concentrates, the dry Callicarpa nudiflora extract C that gets;
(4) the Callicarpa nudiflora raw material of employing fresh state obtains pressed liquor and press residue through squeezing, and press residue adds water or rare alcohol or rare ketone solvent, heating extraction, and extracting solution and pressed liquor merge, and filter, and filtrate concentrates, the dry Callicarpa nudiflora extract D that gets;
(5) the Callicarpa nudiflora raw material of employing fresh state obtains pressed liquor and press residue through squeezing, and press residue adds water or rare alcohol or rare ketone solvent, heating extraction, extracting solution and pressed liquor merge, and filter, and filtrate is passed through macroporous adsorbent resin column chromatography, wash cylinder with water, discard water lotion, the ethanol elution of reuse 10%～90%, eluent filters, concentrate the dry Callicarpa nudiflora extract E that gets;
(6) adopt fresh or exsiccant Callicarpa nudiflora raw material, add water or rare alcohol or rare ketone and decoct secondary, collecting decoction filters, concentrate, carry out membrane filtration, use earlier ultrafiltration, nanofiltration again, membrane material concentrates with ceramic composite membrane and poly tetrafluoroethylene, the dry Callicarpa nudiflora F that gets.
The raw material of Callicarpa nudiflora extract adopts the Callicarpa nudiflora aerial parts of fresh or drying regime, the preferred fresh summer and the Callicarpa nudiflora leaf and/or the twig in autumn.
Squeezing described in the method (3) to (5) is that to adopt weight ratio be that the water of 1 ~ 3:1 or rare alcohol or rare ketone mix with fresh Callicarpa nudiflora.
The inventor is in order to realize farthest extracting the effective active composition from Callicarpa nudiflora, the inventor has carried out systematic study, result such as following table 1 to extracting mode (squeeze, heat), collecting time (spring, summer, autumn, winter) and the different drying regimes (fresh, dry product) of Callicarpa nudiflora:
Table 1:
Attention: above index is all by the aquatic foods product.
In the extraction process of routine, general used be the drying in the sun Callicarpa nudiflora, extraction yield, total flavones and luteolin, the total tannin content that result of study illustrates Callicarpa nudiflora and collecting season, extracting mode are relevant with the medicinal material drying state.
1) extraction yield, total flavones and the luteolin of the Callicarpa nudiflora heating extraction of fresh state, total tannin content are all than dry product height mutually of the same period.With the Callicarpa nudiflora of gathering autumn is example, extraction yield in the fresh Callicarpa nudiflora, general flavone content, luteolin, total tannin content are respectively 1.20,1.59,1.52,1.05 times of dry product, illustrate raw material effective ingredient in dry run forfeiture major part.
2) compare with heating extraction, squeeze the obvious yield that improves Callicarpa nudiflora, total flavones and luteolin, total tannin content.With the Callicarpa nudiflora of gathering autumn is example, and the yield that fresh Callicarpa nudiflora squeezes, general flavone content, content of luteolin are respectively 1.13,1.23,1.20,1.14 times of dry product.
3) yield of the Callicarpa nudiflora of different collecting seasons, total flavones and luteolin, total tannin content have certain difference, studies show that extraction yield, total flavones and the luteolin in summer and period in autumn, total tannin content are better than spring and winter.
(2) preparation of Callicarpa nudiflora series daily use chemicals cleaning product:
1, handwashing liquid
Prescription: (%) counts by weight, surfactant 10-55%(such as polyoxyethylenated alcohol sodium sulfate 3-20%, lauryl alcohol sulfuric ester triethanolamine salt 3-15%, dodecyldimethylammonium hydroxide inner salt 3-15%, lauryl glucosyl 1-5%), EDTA-2Na 0.1-0.5%, citric acid 0.01-3%, essence 0.1-1.5%, Callicarpa nudiflora extract 1-20%, surplus is a deionized water.
Method for making: with surfactant (as polyoxyethylenated alcohol sodium sulfate, lauryl alcohol sulfuric ester triethanolamine salt, dodecyldimethylammonium hydroxide inner salt, lauryl glucosyl), EDTA-2Na, deionized water mix homogeneously, be heated to 75 ℃, treat all to be dissolved to transparence, stirring is cooled to 45 ℃, add essence and Callicarpa nudiflora extract, it is 6-7 that citric acid is transferred pH, stirs and slowly is cooled to room temperature, promptly.
, soap
Prescription: (%) counts by weight, soap base 70-90%, and titanium dioxide 0.1-0.6%, EDTA-2Na 0.01-0.15%, essence 0.1-1.5%, Callicarpa nudiflora extract 1-20%, surplus is a deionized water.
Method for making: with soap base and titanium dioxide, EDTA-2Na, essence, Callicarpa nudiflora extract, deionized water mix homogeneously, after grinder grinds evenly, again through vacuum press strip cutting block forming.
, foot lotion
Prescription:(%) counts by weight, surfactant 10-55%(such as polyoxyethylenated alcohol sodium sulfate 5-30%, dodecyldimethylammonium hydroxide inner salt 5-25%), salicylic acid 0.1-1%, glycerol 0.5-2%, white oil 0.5-2%, Callicarpa nudiflora extract 1-20%, essence 0.1-1.5%, surplus is a deionized water.
Method for making: deionized water is heated to 65 ℃, add surfactant (as polyoxyethylenated alcohol sodium sulfate, dodecyldimethylammonium hydroxide inner salt), salicylic acid, glycerol, white oil while stirring, it is even to be stirred to whole dissolvings, be cooled to 45 ℃, add essence and Callicarpa nudiflora extract, stir and slowly be cooled to room temperature, promptly.
, bath foam
Prescription: weight (%) meter, surfactant 10-55%(such as polyoxyethylene lauryl ether sulfuric ester sodium salt 3-15%, lauryl alcohol sulfuric ester triethanolamine salt 4-25%, cocamido propyl betaine 3-15%), lanoline 0.1-1.5%, essence 0.1-1.5%, Callicarpa nudiflora extract 1-20%, surplus is a deionized water.
Method for making: with surfactant (as polyoxyethylene lauryl ether sulfuric ester sodium salt, lauryl alcohol sulfuric ester triethanolamine salt, cocamido propyl betaine), lanoline, deionized water mix homogeneously, be heated to 75 ℃, treat all to be dissolved to transparence, stirring is cooled to 45 ℃, add essence and Callicarpa nudiflora extract, stir and slowly be cooled to room temperature, promptly.
, liquid detergent
Prescription: weight (%) meter, surfactant 10-55%(such as cocos nucifera oil alkanolamide 6501,3-25%, dodecylbenzene sodium sulfonate 7-30%), sodium hydroxide 0.1-1.5%, essence 0.1-1.5%, Callicarpa nudiflora extract 1-20%, citric acid 0.01-3%, surplus is a deionized water.
Method for making: surfactant (as dodecylbenzene sodium sulfonate) and deionization waterside heating edge are stirred evenly to 75 ℃, adding sodium hydroxide dissolves fully to it, the back adds surfactant (as cocos nucifera oil alkanolamide 6501), stirring is cooled to 45 ℃, add essence and Callicarpa nudiflora extract, adding citric acid accent pH is 6-7, and stirring slowly is cooled to room temperature, promptly.
The surfactant of using always in the said goods comprises but is not limited to as polyoxyethylenated alcohol sodium sulfate, lauryl alcohol sulfuric ester triethanolamine salt, dodecyldimethylammonium hydroxide inner salt, lauryl glucosyl, polyoxyethylene lauryl ether sulfuric ester sodium salt, cocamido propyl betaine, cocos nucifera oil alkanolamide.
Used essence is the essence that laws and regulations allow interpolation in the said goods, includes but not limited to Fructus Citri Limoniae essence, Citrua paradiai essence, rose essence, jasmin essence, lilac compound.
(3) Callicarpa nudiflora extract effect experiment
1, antibacterial experiment
(1) Callicarpa nudiflora extract antibacterial experiment
By external bacteriostatic experiment, with the Callicarpa nudiflora extract of minimum inhibitory concentration (MIC) and the present invention of minimal bactericidal concentration (MBC) index evaluation preparation antibacterial action to common bacterial strain.
The preparation of bacterium liquid: the picking slant strains is inoculated in 20% N and soaks in the juice culture medium, 37 ℃ of overnight incubation, and reuse soaks the juice culture medium for 20% N bacterium liquid is diluted to 10cfu/ml, immediately inoculation.
MIC measures: adopt the liquid tube serial dilution, soak the juice culture medium with 20% N sample is done continuous two-fold dilution.1.0 ml are added in the sterilization test tube, and every pipe adds the fresh bacterium liquid of 0.05 ml standard, and establishes bacterial strain contrast and solvent matched group, cultivates 18～24 hours for 37 ℃, observes the bacterial growth situation, is MIC with the high dilution of asepsis growth.
MBC measures: adopt the plate streaking inocalation method, the picking culture fluid is seeded on the 10% serum MH bouillon agar flat board from the culture medium that is judged to adjacent two pipes of MIC and MIC, cultivated 18～24 hours for 37 ℃, and be MBC with the high dilution of growth clump count≤5.
Result of the test sees Table 2.
Table 2 Callicarpa nudiflora extract in-vitro antibacterial result of the test
The bright medicinal substances extract of the Callicarpa nudiflora of the present invention preparation and the dried medicinal substances extract of Callicarpa nudiflora all have all has in various degree inhibition and killing action and Callicarpa nudiflora aquatic foods medicinal substances extract better effects if to staphylococcus aureus, escherichia coli, Bacillus typhi, streptococcus pneumoniae, bacillus pyocyaneus, group B streptococcus, Bing Xinglianqiujun and helicobacter pylori.
(2) product bacteriostasis antibiosis effect experiment of the present invention
The evaluation of the fungistatic effect of product of the present invention is carried out bacteriostatic test according to QB/T 2738-2005 " daily chemical products antibacterial bacteriostatic Evaluation on effect method ", and test strain is pressed QB/T 2738-2005 " daily chemical products antibacterial bacteriostatic Evaluation on effect method " and is gold-coloured staphylococci, escherichia coli, Candida albicans, bacillus pyocyaneus.Antibacterial effect is evaluated as A2 level higher level (antibiotic rate 〉=50%), and fungistatic effect is for being B2 level higher level (bacteriostasis rate 〉=50%).
, skin irritation test
According to Ministry of Public Health " cosmetics health standard " 2007 editions, the sample of the present invention of inspecting by ready samples is carried out toxicological experiment, under the experiment condition of Municipal Disease Control and Prevention Center, experimental result shows that Cavia porcellus repeatedly skin irritation test result is a nonirritant.
(1) acute skin irritation experiment
Get 10 of Cavia porcelluss, the spinal column diamond wool is cut, each 3cm * 3cm about the unhairing scope is coated in the about 0.5g of submitted sample on the one side skin, cover with two layers of gauze and one deck cellophane, and the immobilization with adhesive tape of reuse nonirritant, opposite side is in contrast.Carry out enclosed experiment, application 4h, warm water cleans and removes residual given the test agent behind the 4h.
Remove 1 h, 24 h, 48 h, 72 h behind the residual given the test agent and observe and smear the dermoreaction at position, and according to the form below 3 carries out the dermoreaction scoring.
(2) skin irritation test repeatedly
Get 10 of Cavia porcelluss, the spinal column diamond wool is cut, each 3cm * 3cm about the unhairing scope, application area is 2.5cm * 2.5cm, and submitted sample is coated in the about 0.5g of submitted sample on the one side skin, opposite side is in contrast.Smear every day once, smeared continuously 14 days.Since the 2nd day, first cropping before smearing, water cleans removes residual receipts test agent, observes dermoreaction behind the 1h, according to the form below 3 scorings.
Table 3 skin irritation reaction scoring
The integration of experimental result is zero, shows product nonirritant of the present invention.
The present invention has following advantage and technique effect with respect to prior art:
(1) inventor adds Callicarpa nudiflora in handwashing liquid, soap, foot lotion, bath foam, the liquid detergent series daily use chemicals cleaning product first, by Callicarpa nudiflora extract and surfactant or other combination of active principles, strengthen the bactericidal effect, nonirritant, prepared Callicarpa nudiflora series daily use chemicals cleaning product safety, effect uniqueness;
(2) the bright medical material of the preferred Callicarpa nudiflora of the present invention is a raw material, and its active component total flavones and content of luteolin are than the dry product height, and extraction ratio improves greatly, helps saving cost, improves resource utilization.Be raw material directly on the other hand, reduce the loss of active substance, help improving the effect that active substance becomes to hive off, improve the action effect of product with the bright product of Callicarpa nudiflora.
The specific embodiment
The preparation of embodiment 1, Callicarpa nudiflora extract
Adopt the preparation of following either party's method, get one or more mixing wherein:
(1) adopt the fresh or dried feed of Callicarpa nudiflora, add entry or rare alcohol or rare ketone solvent, heating extraction, extracting solution filters, and filtrate concentrates, the dry Callicarpa nudiflora extract a that gets;
(2) adopt the fresh or dried feed of Callicarpa nudiflora, add entry or rare alcohol or rare ketone solvent, heating extraction, extracting solution filters, and filtrate is passed through macroporous adsorbent resin column chromatography, wash cylinder with water, discard water lotion, reuse 10%～90% ethanol elution, eluent filters, concentrate the dry Callicarpa nudiflora extract b that gets;
(3) the Callicarpa nudiflora raw material of fresh state obtains pressed liquor and press residue through squeezing, and pressed liquor filters, and filtrate concentrates, the dry Callicarpa nudiflora extract c that gets;
(4) the Callicarpa nudiflora raw material of employing fresh state obtains pressed liquor and press residue through squeezing, and press residue adds water or rare alcohol or rare ketone solvent, heating extraction, and extracting solution and pressed liquor merge, and filter, and filtrate concentrates, the dry Callicarpa nudiflora extract d that gets;
(5) the Callicarpa nudiflora raw material of employing fresh state obtains pressed liquor and press residue through squeezing, and press residue adds water or rare alcohol or rare ketone solvent, heating extraction, extracting solution and pressed liquor merge, and filter, and filtrate is passed through macroporous adsorbent resin column chromatography, wash cylinder with water, discard water lotion, the ethanol elution of reuse 10%～90%, eluent filters, concentrate the dry Callicarpa nudiflora extract e that gets;
(6) adopt fresh or exsiccant Callicarpa nudiflora raw material, add water or rare alcohol or rare ketone and decoct secondary, collecting decoction filters, concentrate, carry out membrane filtration, use earlier ultrafiltration, nanofiltration again, membrane material concentrates with ceramic composite membrane and poly tetrafluoroethylene, the dry Callicarpa nudiflora f that gets.
Embodiment 2:
Get the fresh Callicarpa nudiflora leaf 1kg that gathers October, add 2kg water and be broken into homogenate, squeezing, press residue adds 3kg water heating extraction, extracting solution and pressed liquor merge, filter, concentrate, the dry 124.7g extract that gets, it is 12.47% that Callicarpa nudiflora extracts yield, recording general flavone content is 61.1mg/g, and content of luteolin is 0.74mg/g, and total tannin content 15.45 mg/g(are by fresh medical material).
Embodiment 3
Get Callicarpa nudiflora leaf and twig 2.0kg(dry product), add rare ketone and decoct secondary, 10 times of amounts decocted 2 hours for the first time, 8 times of amounts decocted collecting decoction 1 hour for the second time, filter, be concentrated into 2000ml, carry out membrane filtration, earlier use ultrafiltration, nanofiltration again, membrane material ceramic composite membrane and poly tetrafluoroethylene, concentrate, drying gets the 290.1g Callicarpa nudiflora extract, it is 14.5% that Callicarpa nudiflora extracts yield, and recording general flavone content is 115.9mg/g, and content of luteolin is that 1.31mg/g(is by dry product).
Embodiment 4
Get the bright product of Callicarpa nudiflora leaf and twig 2.0kg(), decoct with water secondary, each 10 times of amounts, decocted 2 hours, collecting decoction filters, be concentrated into 2000ml, carry out membrane filtration, use earlier ultrafiltration, nanofiltration again, membrane material concentrates with ceramic composite membrane and poly tetrafluoroethylene, drying gets the 125.7g Callicarpa nudiflora extract, and it is 6.28% that Callicarpa nudiflora extracts yield, recording general flavone content is 50.4mg/g, and content of luteolin is that 0.70mg/g(is by the aquatic foods product).
Embodiment 5
Get the fresh Callicarpa nudiflora leaf 1kg that gathers August, add 2kg water and be broken into homogenate, squeezing, press residue adds the rare pure heating extraction of 3kg, and extracting solution and pressed liquor merge, and filters, filtrate washes cylinder with water by macroporous adsorbent resin column chromatography, discards water lotion, the ethanol elution of reuse 75% takes off liquid and filters, and concentrates, the dry 88.5g extract that gets, it is 8.85% that Callicarpa nudiflora extracts yield, and recording general flavone content is 58.7mg/g, and content of luteolin is that 0.72mg/g(is by fresh medical material).
Embodiment 6
Get the fresh Callicarpa nudiflora leaf 1kg that gathers October, heating extraction twice adds rare ketone 9kg at every turn, extracts 2 hours, merging filtrate, filter, concentrate, the dry 93.7g extract that gets, it is 9.37% that Callicarpa nudiflora extracts yield, recording general flavone content is 49.5mg/g, and content of luteolin is 0.75mg/g, and total tannin content 13.87 mg/g(are by fresh medical material).
Embodiment 7
Get Callicarpa nudiflora leaf and twig 2.0kg(dry product), heating extraction twice adds rare pure 10kg at every turn, extracts 2 hours, merging filtrate, filter, concentrate, the dry 485.8g extract that gets, it is 24.3% that Callicarpa nudiflora extracts yield, recording general flavone content is 104.7mg/g, and content of luteolin is 1.29mg/g, and total tannin content 38.4 mg/g(are by dry product).
Embodiment 8, handwashing liquid
Prescription: (%) counts by weight, polyoxyethylenated alcohol sodium sulfate 10%, lauryl alcohol sulfuric ester triethanolamine salt 8%, dodecyldimethylammonium hydroxide inner salt 4%, lauryl glucosyl 4%, EDTA-2Na 0.1%, citric acid 0.05-1%, essence 1%, Callicarpa nudiflora extract 8%, surplus is a deionized water.
Method for making: with polyoxyethylenated alcohol sodium sulfate, lauryl alcohol sulfuric ester triethanolamine salt, dodecyldimethylammonium hydroxide inner salt, lauryl glucosyl, EDTA-2Na, deionized water mix homogeneously, be heated to 75 ℃, treat all to be dissolved to transparence, stirring is cooled to 45 ℃, add essence and Callicarpa nudiflora extract, it is 6-7 that citric acid is transferred pH, stirs and slowly is cooled to room temperature, promptly.
Embodiment 9, soap
Prescription: (%) counts by weight, soap base 88%, and titanium dioxide 0.5%, EDTA-2Na 0.1%, essence 0.2%, Callicarpa nudiflora extract 8%, surplus is a deionized water.
Method for making: with soap base and titanium dioxide, EDTA-2Na, essence, Callicarpa nudiflora extract, deionized water mix homogeneously, after grinder grinds evenly, again through vacuum press strip cutting block forming.
Embodiment 10, foot lotion
Prescription:(%) counts by weight, polyoxyethylenated alcohol sodium sulfate 6%, dodecyldimethylammonium hydroxide inner salt 10%, salicylic acid 1%, glycerol 2%, white oil 2%, Callicarpa nudiflora extract 10%, essence 0.5%, deionized water surplus etc.
Method for making: deionized water is heated to 65 ℃, add polyoxyethylenated alcohol sodium sulfate, dodecyldimethylammonium hydroxide inner salt, salicylic acid, glycerol, white oil while stirring, it is even to be stirred to whole dissolvings, be cooled to 45 ℃, add essence and Callicarpa nudiflora extract, stir and slowly be cooled to room temperature, promptly.
Embodiment 11, bath foam
Prescription: (%) counts by weight, polyoxyethylene lauryl ether sulfuric ester sodium salt 14%, and lauryl alcohol sulfuric ester triethanolamine salt 16%, cocamido propyl betaine 8%, lanoline 1%, essence 0.8%, Callicarpa nudiflora extract 4%, surplus is a deionized water.
Method for making: with polyoxyethylene lauryl ether sulfuric ester sodium salt, lauryl alcohol sulfuric ester triethanolamine salt, cocamido propyl betaine, lanoline, deionized water mix homogeneously, be heated to 75 ℃, treat all to be dissolved to transparence, stirring is cooled to 45 ℃, add essence and Callicarpa nudiflora extract, stir and slowly be cooled to room temperature, promptly.
Embodiment 12, liquid detergent
Prescription: (%) counts by weight, cocos nucifera oil alkanolamide 6501,3%, and dodecylbenzene sodium sulfonate 8%, sodium hydroxide 1%, essence 0.2%, Callicarpa nudiflora extract 10%, citric acid 0.05-1%, surplus is a deionized water.
Method for making: dodecylbenzene sodium sulfonate and deionization waterside heating edge are stirred evenly to 75 ℃, adding sodium hydroxide dissolves fully to it, the back adds cocos nucifera oil alkanolamide 6501, stirring is cooled to 45 ℃, add essence and Callicarpa nudiflora extract, adding citric acid accent pH is 6-7, and stirring slowly is cooled to room temperature, promptly.
Claims (5)
1. the application of Callicarpa nudiflora extract according to claim 1 in the daily use chemicals cleaning product is characterized in that described Callicarpa nudiflora extract adds in the daily use chemicals cleaning product.
2. Callicarpa nudiflora extract according to claim 1 is used in the daily use chemicals cleaning product, it is characterized in that: the daily use chemicals cleaning product comprises handwashing liquid, soap, foot lotion, bath foam, liquid detergent.
3. Callicarpa nudiflora extract according to claim 1 is used in the daily use chemicals cleaning product, it is characterized in that: described Callicarpa nudiflora extract is water, alcohol or the diluted ketone extraction thing of fresh or dry Callicarpa nudiflora raw material.
4. Callicarpa nudiflora extract according to claim 3 is used in the daily use chemicals cleaning product, it is characterized in that: described Callicarpa nudiflora extract prepares by following any method:
(1) adopt the fresh or dried feed of Callicarpa nudiflora, add entry or rare alcohol or rare ketone solvent, heating extraction, extracting solution filters, and filtrate concentrates, the dry Callicarpa nudiflora extract A that gets;
(2) adopt the fresh or dried feed of Callicarpa nudiflora, add entry or rare alcohol or rare ketone solvent, heating extraction, extracting solution filters, and filtrate is passed through macroporous adsorbent resin column chromatography, wash cylinder with water, discard water lotion, reuse 10%～90% ethanol elution, eluent filters, concentrate the dry Callicarpa nudiflora extract B that gets;
(3) the Callicarpa nudiflora raw material of fresh state obtains pressed liquor and press residue through squeezing, and pressed liquor filters, and filtrate concentrates, the dry Callicarpa nudiflora extract C that gets;
(4) the Callicarpa nudiflora raw material of employing fresh state obtains pressed liquor and press residue through squeezing, and press residue adds water or rare alcohol or rare ketone solvent, heating extraction, and extracting solution and pressed liquor merge, and filter, and filtrate concentrates, the dry Callicarpa nudiflora extract D that gets;
(5) the Callicarpa nudiflora raw material of employing fresh state obtains pressed liquor and press residue through squeezing, and press residue adds water or rare alcohol or rare ketone solvent, heating extraction, extracting solution and pressed liquor merge, and filter, and filtrate is passed through macroporous adsorbent resin column chromatography, wash cylinder with water, discard water lotion, the ethanol elution of reuse 10%～90%, eluent filters, concentrate the dry Callicarpa nudiflora extract E that gets;
(6) adopt fresh or exsiccant Callicarpa nudiflora raw material, add water or rare alcohol or rare ketone and decoct secondary, collecting decoction filters, concentrate, carry out membrane filtration, use earlier ultrafiltration, nanofiltration again, membrane material concentrates with ceramic composite membrane and poly tetrafluoroethylene, the dry Callicarpa nudiflora F that gets.
5. Callicarpa nudiflora extract according to claim 2 is used in the daily use chemicals cleaning product, it is characterized in that: Callicarpa nudiflora extract is the 1-20% of described daily use chemicals cleaning product weight.
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| CN103666890A (en) * | 2013-12-19 | 2014-03-26 | 青岛琴诚医药技术有限公司 | Traditional Chinese medicinal liquid soap |
| WO2014075570A1 (en) * | 2012-11-19 | 2014-05-22 | 苏州润新生物科技有限公司 | Beautyberry total glycosides extract and preparation method and use thereof |
| CN104130889A (en) * | 2014-08-15 | 2014-11-05 | 吴江市德佐日用化学品有限公司 | Face-moistening and skin-cleansing soap and preparation method thereof |
| CN105078803A (en) * | 2014-05-16 | 2015-11-25 | 苏州润新生物科技有限公司 | Application of callicarpa plant extract |
| CN108524684A (en) * | 2018-06-28 | 2018-09-14 | 黄河科技学院 | Effective fraction with anti-cervicitis effect in callicarpa nudiflora |
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| CN103816296B (en) * | 2012-11-19 | 2020-03-31 | 苏州润新生物科技有限公司 | Callicarpa total glycoside extract and preparation method and application thereof |
| US10758585B2 (en) | 2012-11-19 | 2020-09-01 | Suzhou Neupharma Co., Ltd. | Beautyberry total glycosides extract and preparation method and use thereof |
| CN103666890A (en) * | 2013-12-19 | 2014-03-26 | 青岛琴诚医药技术有限公司 | Traditional Chinese medicinal liquid soap |
| CN105078803A (en) * | 2014-05-16 | 2015-11-25 | 苏州润新生物科技有限公司 | Application of callicarpa plant extract |
| CN105078803B (en) * | 2014-05-16 | 2020-03-31 | 苏州润新生物科技有限公司 | Use of Callicarpa plant extract |
| CN104130889A (en) * | 2014-08-15 | 2014-11-05 | 吴江市德佐日用化学品有限公司 | Face-moistening and skin-cleansing soap and preparation method thereof |
| CN108524684A (en) * | 2018-06-28 | 2018-09-14 | 黄河科技学院 | Effective fraction with anti-cervicitis effect in callicarpa nudiflora |
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| CN102266277B (en) | 2014-08-13 |
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