CN102217604B - Bactericidal composition containing boscalid and triazole compounds - Google Patents
Bactericidal composition containing boscalid and triazole compounds Download PDFInfo
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Abstract
The invention relates to a bacteriocidal composition containing boscalid and triazole compounds, comprising an active component A and an active component B, wherein, the active component A is selected from boscalid, the active component B is selected from one of imibenconazole, triticonazole, ipconazole or fenbuconazole, and the weight ratio of the active component A to B is 1-80%:1-60%. The composition of the present invention can be prepared into dosage forms, such as wettable powder, water dispersible granule, suspending agent, suspended emulsion, suspending seed coating agent, emulsion in water or micron emulsion, by adding auxiliary agents and excipients into the active components, used for controlling powdery mildew, botrytis, net blotch, rice blast, elsinoe ampelina, septoria nodorum, rust, anthracnose, root rot, rot disease, brown rot, apple scab, leaf spot, epidemic disease, black rot, brown spot, scab and leaf rust, with effects of little chemical consumption, anti-rain wash and obvious synergistic action.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of application of bactericidal composition on crop pest that contains Boscalid and triazole class compounds.
Technical background
Boscalid, English name: boscalid molecular formula: C
18H
12Cl
2N
2The O chemical name: 2-chloro-N-(4 '-chlordiphenyl-2-yl) vitamin PP.
Boscalid is a kind of pyridines bactericide, permeates in plant by the blade face and shifts, and suppresses mitochondrial succinate ester dehydrase; hinder tricarbonic acid cycle, amino acid, sugar shortage, energy are reduced, the division of interference cell and growth; disease there is neural activity, has protection and therapeutic action.Suppress the Main Stage that spore germination, the extension of bacterium pipe, mycelial growth and spore mother cell form conk and breeding, bactericidal action is directly caused there is no corresponding metabolic activity by the parent active substance.More than 800 results of net blotch of general bactericide generation resistance having been tested that are separated are shown, it and other bactericide are without cross resistance.
Glyoxalin (imibenconazole), molecular formula: C
17H
13Cl
3N
4S, chemical name: 4-chlorobenzyl N-(2,4-dichlorophenyl)-2 (1H-1,2,4-triazol-1-yl) thioacetamide ester, glyoxalin are a kind of efficient, wide spectrum triazole bactericidal agents.Be mainly the biosynthesis that destroys and stop the cell membrane important component part ergosterol of germ, thereby destroyed the formation of cell membrane, cause germ dead.After being sprayed onto on crop, the energy rapid osmotic is in plant corpus, and resistance of rainwater washing against has protection and therapeutic action.
Metconazole (metconazole), molecular formula: C
17H
22ClN
3O, chemical name: (1RS, 5RS; 1RS, 5SR)-5-(4-chlorphenyl)-2,2-dimethyl-1-(1-hydrogen-1,2,4-triazole-1-methyl) cyclopentanol, C-14 demethylation enzyme inhibitor in the ergosterol biosynthesis.Although the mechanism of action is the same with other triazole bactericidal agents, activity profile difference is larger.Two kinds of isomer have bactericidal activity, but the cis activity is higher than trans.The antifungal spectrum of metconazole is very extensive, and active splendid.The metconazole field is used and cereal septoria musiva, fusarium and handle rest fungus is planted disease remarkable effect is arranged.Metconazole is compared with traditional biocide agent, and dosage is extremely low and prevent and treat cereal to plant the disease scope very wide.
Triticonazole (triticonazole), molecular formula: C
17H
20ClN
3O, chemical name: (±)-(E)-5-(4-benzyl chloride thiazolinyl)-2,2-dimethyl-1-(1H-1,2,4-triazol-1-yl methyl) cyclopentanol, C-14 demethylation enzyme inhibitor in sterol biosynthesis.Main as seed treatment.
Plant bacterium azoles (ipconazole), molecular formula: C
18H
24ClN
3O, chemical name: the 2-[(4-chlorphenyl) methyl]-5-(1-isopropyl)-1-(1H-1,2,4-triazol-1-yl methyl) cyclopentanol, ergosterol biosynthesis inhibitor, the seed-borne disease that is mainly used in preventing and treating paddy rice and other crops.
RH-7592 (fenbuconazole), molecular formula: C
19H
17ClN
4, chemical name: 4-(4-chlorphenyl)-2-phenyl-2 (1H-1,2,4-triazol-1-yl methyl) butyronitrile belongs to ergosterol biosynthesis inhibitor (EBI).Have protection concurrently, cure the disease and the interior absorption spectrum bactericide of killing action.
In the real process of agricultural production, preventing and treating the problem that disease the most easily produces is the drug-fast generation of germ.The different cultivars composition carries out composite, is to prevent and treat the very common method of resistance germ.Heterogeneity is carried out composite, according to practical application effect, judge certain composite be synergy, add and or antagonism.In most cases, the composite effect of agricultural chemicals is all additive effect, and the seldom composite of synergistic effect really arranged, especially synergistic effect very obviously, synergy ratio very high composite just still less.Through inventor's research, discovery is mutually composite with Boscalid and effective active composition B, good synergistic effect is arranged within the specific limits, and relevant composite about Boscalid and glyoxalin, metconazole, triticonazole, kind bacterium azoles, RH-7592, there is not yet at present relevant report at home and abroad.
Summary of the invention
The objective of the invention is to propose a kind of have synergistic function, use cost is low, preventive effect the is good bactericidal composition that contains Boscalid and triazole class compounds.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition that contains Boscalid, it is characterized in that: the percentage by weight of A, two kinds of active components of B is 1～80%: 1～60%, described A component is Boscalid, and the B component is selected from a kind of in glyoxalin, metconazole, triticonazole, kind bacterium azoles or RH-7592.
The described bactericidal composition that contains Boscalid is characterized in that: wherein the percentage by weight of A, two kinds of active components of B is 5～70%: 1～50%.
The described bactericidal composition that contains Boscalid is characterized in that: the percentage by weight of Boscalid and glyoxalin is 10～60%: 5～20%.
The described bactericidal composition that contains Boscalid is characterized in that: the percentage by weight of Boscalid and metconazole is 10～60%: 1～20%.
The described bactericidal composition that contains Boscalid is characterized in that: the percentage by weight of Boscalid and triticonazole is 10～60%: 1～20%.
The described bactericidal composition that contains Boscalid is characterized in that: Boscalid is 10～60%: 1～20% with the percentage by weight of planting the bacterium azoles.
The described bactericidal composition that contains Boscalid is characterized in that: the percentage by weight of Boscalid and RH-7592 is 10～60%: 1～20%.
The described bactericidal composition that contains Boscalid, wherein the effective active component content accounts for 1～95% of gross weight, is preferably 5～80%.
The described bactericidal composition that contains Boscalid is made wetting powder, water dispersible granules, suspending agent, suspension emulsion, suspension seed-coating agent, aqueous emulsion or microemulsion.
Described bactericidal composition is mainly used in preventing and treating the application of the plant diseases such as powdery mildew, gray mold, net blotch, rice blast, anthrachose of grape, glume blight, rust, anthracnose, root rot, rot, brown spot, scab, leaf spot, black spot, brown spot, shot hole, leaf rust.
Amount of application when in the present composition, the content of active component depends on independent use also depends on mixed ratio and the synergistic effect degree of a kind of compound and another kind of compound, and the while is also relevant with the target fungi.Usually in composition, active weight percentage is 0.5～90% of gross weight, and better is 5%～85%.According to different preparation types, the active component content scope is different.Usually, liquid preparation contains 1～70% active substance by weight, is preferably 5～50%; Solid pharmaceutical preparation contains 5～85% active substance by weight, is preferably 10～80%.
At least contain a kind of surfactant in bactericidal composition of the present invention, the dispersion of active component in water when being beneficial to use.Surface-active contents is 5～30% of total formulation weight amount, and surplus is solid or liquid diluent.
The selected surfactant of bactericidal composition of the present invention is known in those skilled in the art: can be selected from one or more in dispersant, wetting agent, thickener or defoamer.According to different dosage form, can also contain stabilizing agent known in those skilled in the art, antifreeze etc. in preparation.
Bactericidal composition of the present invention can be processed into acceptable formulation on any agricultural chemicals on demand.Wherein preferred dosage form is wetting powder, water dispersible granules, suspending agent, suspension emulsion, suspension seed-coating agent, aqueous emulsion or microemulsion.
When making wetting powder, composition comprises following constituent content: Boscalid 1～80%, active component B1～60%, dispersant 5～10%, wetting agent 2～10%, filler 8～90%.
The former medicine of Boscalid, the former medicine of active component B, dispersant, wetting agent, filler are mixed, mix in mixed cylinder, mix again after airslide disintegrating mill is pulverized, namely can be made into the wetting powder product of the present composition.
When making water dispersible granules, composition comprises following constituent content: Boscalid 1～80%, active component B1～60%, dispersant 3～12%, wetting agent 1～8%, disintegrant 1～10%, binding agent 1～8%, filler 10～92%.
The former medicine of Boscalid, the former medicine of active component B, dispersant, wetting agent, disintegrant, filler etc. are obtained through air-flow crushing the particle diameter that needs together, then add other auxiliary agent such as binding agent, obtain the preparation materials.With item quantitatively send in the fluidized bed granulation dryer through granulation and drying after, make the water dispersible granules product of the present composition.
When making suspending agent, composition comprises following constituent content: Boscalid 1～40%, active component B1～20%, dispersant 2～10%, wetting agent 2～10%, defoamer 0.1～1%, thickener 0.1～2%, antifreeze 0.1～8%, stabilizing agent 0.05～3%, deionized water adds to 100%.
Dispersant, wetting agent, defoamer, thickener, antifreeze in above-mentioned formula are mixed through high speed shear, add the former medicine of Boscalid, the former medicine of active component B, ball milling is 2～3 hours in ball mill, make diameter of particle all below 5 μ m, make the suspending agent product of the present composition.
Comprise following constituent content when composition is made suspension emulsion: Boscalid 1～40%, active component B1～20%, emulsifier 2～12%, dispersant 2～10%, defoamer 0.1～2%, thickener 0.1～2%, antifreeze 0.1～8%, stabilizing agent 0.05～3%, water add to 100%.
Dispersant, defoamer, thickener, antifreeze, stabilizing agent in above-mentioned formula are mixed through high speed shear, add the former medicine of active component B, ball milling is 2～3 hours in ball mill, make diameter of particle all below 5 μ m, make active component B suspending agent, then with the former medicine of Boscalid, emulsifier and various auxiliary agent with the direct emulsification of high speed agitator in suspending agent, make the suspension emulsion product of the present composition.
When making aqueous emulsion, composition comprises following constituent content: Boscalid 1～40%, active component B1～20%, solvent 2～10%, emulsifier 2～12%, dispersant 2～10%, co-emulsifier 0.2～5%, antifreeze 0.1～8%, defoamer 0.1～2%, thickener 0.1～2%, deionized water adds to 100%.
Be dissolved into even oil phase with having former medicine, solvent, emulsifier, co-emulsifier to be added together in above-mentioned formula, making.With deionized water, dispersant, antifreeze,, defoamer, thickener mix, and becomes the homogeneous water, under high-speed stirred, water slowly splashed into oil phase, makes the finely disseminated aqueous emulsion product of the present composition.
When making microemulsion, composition comprises following constituent content: Boscalid 1～40%, active component B1～20%, emulsifier 5～15%, and solvent 2～10%, antifreeze 5～10%, stabilizing agent 0.5～3%, deionized water adds to 100%.
When making suspension seed-coating agent, composition comprises following constituent content: Boscalid 1～20%, active component B1～10%, film forming agent 3～6%, binding agent 2～5%, dispersant 2～10%, wetting agent 2～5%, antifreeze 0.1～8%, defoamer 0.1～2%, thickener 0.1～2%, water 10～92%.
The former medicine of Boscalid, active ingredient B in above-mentioned formula are mixed, carry out high-speed wet type pulverizing, frosted, then add dispersant, binding agent, film forming agent, wetting agent, antifreeze, water etc., mix through modulation kettle, make present composition suspension seed-coating agent product.
Beneficial effect of the present invention: (1) present composition effective active composition Boscalid and effective active composition B belong to the bactericide of two kinds of different mechanisms of action, and both mutually are mixed and can produce conflict; (2) present composition has good synergistic effect within the specific limits, and preventive effect is higher than single dose, and dosage is little; (3) with an organic solvent consumption is few in the present invention, is difficult for producing poisoning, is convenient to transportation and storage; (4) present composition has enlarged fungicidal spectrum, and crop powdery mildew, gray mold, net blotch, rice blast, anthrachose of grape, glume blight, rust, anthracnose, root rot, rot, brown spot, scab, leaf spot, black spot, brown spot, shot hole, leaf rust are all had special efficacy.
Embodiment
To further instruction of the present invention, the percentage in embodiment all is weight percentage below in conjunction with embodiment, but the present invention is not limited thereto.
The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.
Application Example one
Example 1 70% Boscalid glyoxalin wetting powder
Boscalid 65%, glyoxalin 5%, lignosulfonates 5.5%, tea are withered 5%, attapulgite 5%, and kaolin adds to 100%, and mixture carries out air-flow crushing, makes 70% Boscalid glyoxalin wetting powder.
Example 2 60% Boscalid Imibenconazole water dispersible granules
Boscalid 50%, glyoxalin 10%, naphthalene sulfonic acid-formaldehyde condensation product 4%, silkworm excrement 2.8%, sodium bicarbonate 3.2%, kaolin add to 100%, mix to make 60% Boscalid Imibenconazole water dispersible granule.
Example 3 40% Boscalid glyoxalin suspending agents
Boscalid 30%, glyoxalin 10%, aryl phenol polyoxyethylene succinate sulfonate 4%, neopelex 5%, C10～20 saturated fat acids 0.5%, xanthans 2.5%, triethylene glycol 1.8%, deionized water add to 100%, mix to make 40% Boscalid glyoxalin suspending agent.
Example 4 40% Boscalid glyoxalin suspension emulsions
Boscalid 25%, glyoxalin 15%, naphthalene sulfonic acid-formaldehyde condensation product 6%, tea are withered 5%, crosslinked crospolyvinylpyrrolidone 1.5%, OP series 7%, glycerine 2.2%, C10～20 saturated fat acids 1.5%, water add to 100%, make 40% Boscalid glyoxalin suspension emulsion through mixing.
Example 5 30% Boscalid glyoxalin aqueous emulsions
Boscalid 25%, glyoxalin 5%, DMF 6%, alkyl biphenyl ether disulfonic acid magnesium salts 5%, butanols 3%, ethylene glycol 5%, C
8～10Aliphatic alcohols 0.8%, deionized water adds to 100%, makes 30% Boscalid glyoxalin aqueous emulsion through mixing.
Example 6 25% Boscalid glyoxalin microemulsions
Boscalid 20%, glyoxalin 5%, styrene polyoxyethylene ether ammonium sulfate salt 5%, cyclohexanone 3%, glycerine 8%, silicone 1.2%, deionized water adds to 100%, makes 25% Boscalid glyoxalin microemulsion through mixing.
Example 7 10% Boscalid glyoxalin suspension seed-coating agents
Boscalid 8%, glyoxalin 2%, fatty alcohol-polyoxyethylene ether 1%, naphthalenesulfonateformaldehyde formaldehyde carboxylic compound 4%, polyvinyl acetate 2%, triethylene glycol 5%, alkylphenol-formaldehyde resin polyoxy ethyl ether 1.2%, C10～20 saturated fat acids 1.2%, naphthenate 20%, water add to 100%, make 10% Boscalid glyoxalin suspension seed-coating agent through mixing.
Example 8 65% Boscalid metconazole wetting powders
Boscalid 55%, metconazole 10%, aryl phenol polyoxyethylene succinate sulfonate 6%, silkworm excrement 5%, attapulgite add to 100%, and mixture carries out air-flow crushing, make 65% Boscalid metconazole wetting powder.
Example 9 64% Boscalid metconazole water dispersible granules
Boscalid 50%, metconazole 14%, polycarboxylate 6%, neopelex 5%, ammonium sulfate 2%, diatomite add to 100%, mix to make 64% Boscalid metconazole water dispersible granules.
Example 10 35% Boscalid metconazole suspending agents
Boscalid 30%, metconazole 5%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 5%, silkworm excrement 5%, C10～20 saturated fat acids 1.8%, xanthans 1.5%, propane diols 3%, deionized water add to 100%, mix to make 35% Boscalid metconazole suspending agent.
Example 11 38% Boscalid metconazole suspension emulsions
Boscalid 30%, metconazole 8%, alkylphenol-polyethenoxy are phonetic 4.5%, neopelex 3.5%, silicone oil 1.5%, crosslinked crospolyvinylpyrrolidone 1.3%, tween series 6%, poly-triethylene glycol 3%, water add to 100%, the aforementioned formula material is mixed, namely make 38% Boscalid metconazole suspension emulsion.
Example 12 25% Boscalid metconazole aqueous emulsions
Boscalid 20%, metconazole 5%, DMF 7%, alkyl biphenyl ether disulfonic acid magnesium salts 5%, butanols 5%, ethylene glycol 3%, C
8～10Aliphatic alcohols 1.5%, deionized water adds to 100%, mixes to make 25% Boscalid metconazole aqueous emulsion.
Example 13 40% Boscalid metconazole microemulsions
Boscalid 38%, metconazole 2%, By series 8%, ethylene glycol monomethyl ether 5%, polyethylene glycol 5%, C
8～10Aliphatic alcohols 1.5%, deionized water adds to 100%, mixes to make 40% Boscalid metconazole microemulsion.
Example 14 8% Boscalid metconazole suspension seed-coating agents
Boscalid 6%, metconazole 2%, fatty alcohol-polyoxyethylene ether 5%, naphthalenesulfonateformaldehyde formaldehyde carboxylic compound 3.5%, polyvinyl acetate 2%, triethylene glycol 5%, alkylphenol-formaldehyde resin polyoxy ethyl ether 1.3%, C10～20 saturated fat acids 0.7%, naphthenate 16%, water add to 100%, make 8% Boscalid metconazole suspension seed-coating agent through mixing.
Example 15 56% Boscalid triticonazole wetting powders
Boscalid 46%, triticonazole 10%, naphthalene sulfonic acid-formaldehyde condensation product 5%, silkworm excrement 5%, starch add to 100%, and mixture carries out air-flow crushing, make 56% Boscalid triticonazole wetting powder.
Example 16 65% Boscalid triticonazole water dispersible granules
Boscalid 55%, triticonazole 10%, lignosulfonates 5%, neopelex 6%, sodium bicarbonate 1.5%, kaolin add to 100%, mix to make 65% Boscalid triticonazole water dispersible granules.
Example 17 25% Boscalid triticonazole suspending agents
Boscalid 20%, triticonazole 5%, aryl phenol polyoxyethylene succinate sulfonate 4%, neopelex 6%, silicone compound 0.6%, crosslinked crospolyvinylpyrrolidone 1.5%, poly-triethylene glycol 1.2%, deionized water adds to 100%, mixes to make 25% Boscalid triticonazole suspending agent.
Example 18 20% Boscalid triticonazole suspension emulsions
Boscalid 10%, triticonazole 10%, aryl phenol polyoxyethylene succinate sulfonate 5%, tea is withered 5%, methylcellulose 1.2%, triethylene glycol 1.3%, C
10～20Saturated fat acids 0.6%, OP series 6%, water add to 100%, mix to make 20% Boscalid triticonazole suspension emulsion.
Example 19 36% Boscalid triticonazole aqueous emulsions
Boscalid 30%, triticonazole 6%, DMF 5%, alkyl biphenyl ether disulfonic acid magnesium salts 6%, butanols 4%, ethylene glycol 3%, C
8～10Aliphatic alcohols 1.5%, deionized water adds to 100%, mixes to make 36% Boscalid triticonazole aqueous emulsion.
Example 20 28% Boscalid triticonazole microemulsions
Boscalid 20%, triticonazole 8%, styrene polyoxyethylene ether ammonium sulfate salt 4%, cyclohexanone 5%, glycerine 6%, silicone 3%, deionized water adds to 100%, mixes to make 28% Boscalid triticonazole microemulsion.
Example 21 5% Boscalid triticonazole suspension seed-coating agents
Boscalid 3%, triticonazole 2%, fatty alcohol-polyoxyethylene ether 5%, naphthalenesulfonateformaldehyde formaldehyde carboxylic compound 3%, polyvinyl acetate 2%, triethylene glycol 5%, alkylphenol-formaldehyde resin polyoxy ethyl ether 2.4%, C10～20 saturated fat acids 1.6%, naphthenate 18%, water add to 100%, make 5% Boscalid triticonazole suspension seed-coating agent through mixing.
Example 22 70% Boscalid kind bacterium azoles wetting powders
Boscalid 55%, kind bacterium azoles 15%, aryl phenol polyoxyethylene succinate sulfonate 6%, silkworm excrement 6%, kaolin add to 100%, and mixture carries out air-flow crushing, makes 70% Boscalid kind bacterium azoles wetting powder.
Example 23 55% Boscalid kind bacterium azoles water dispersible granules
Boscalid 50%, kind bacterium azoles 5%, lignosulfonates 5%, neopelex 6%, urea 1%, attapulgite add to 100%, mix making 55% Boscalid kind bacterium azoles water dispersible granules.
Example 24 25% Boscalid kind bacterium azole suspending agents
Boscalid 20%, kind bacterium azoles 5%, the phonetic formaldehyde condensation products sulphate 7% of alkylphenol-polyethenoxy, neopelex 4%, silicone compound 1.4%, crosslinked crospolyvinylpyrrolidone 1.6%, triethylene glycol 1.5%, deionized water add to 100%, mix making 25% Boscalid kind bacterium azole suspending agent.
Example 25 24% Boscalid kind bacterium azoles suspension emulsions
Boscalid 20%, kind bacterium azoles 4%, lignosulfonates 6%, neopelex 5%, C
10～20Saturated fat acids 0.6%, xanthans 1.2%, agriculture breast 600#5%, poly-triethylene glycol 3%, water add to 100%, and the aforementioned formula material is mixed, and namely make 24% Boscalid kind bacterium azoles suspension emulsion.
Example 26 20% Boscalid kind bacterium azoles aqueous emulsions
Boscalid 16%, kind bacterium azoles 4%, NOP 8%, agriculture breast 1600#7%, calcium chloride 5.2%, glycerine 4%, silicone 1.8%, deionized water adds to 100%, mixes to make 20% Boscalid kind bacterium azoles aqueous emulsion.
Example 27 35% Boscalid kind bacterium azoles microemulsions
Boscalid 30%, kind bacterium azoles 5%, styrene polyoxyethylene ether ammonium sulfate salt 6%, cyclohexanone 5%, glycerine 6%, silicone 3%, deionized water adds to 100%, mixes to make 35% Boscalid kind bacterium azoles microemulsion.
Example 28 6% Boscalid kind bacterium azoles suspension seed-coating agents
Boscalid 3%, metconazole 3%, fatty alcohol-polyoxyethylene ether 5%, naphthalenesulfonateformaldehyde formaldehyde carboxylic compound 4%, polyvinyl acetate 2%, triethylene glycol 3%, alkylphenol-formaldehyde resin polyoxy ethyl ether 1.2%, C10～20 saturated fat acids 0.8%, naphthenate 22%, water add to 100%, make 6% Boscalid kind bacterium azoles suspension seed-coating agent through mixing.
Example 29 50% Boscalid RH-7592 wetting powders
Boscalid 45%, RH-7592 5%, naphthalene sulfonic acid-formaldehyde condensation product 6%, tea are withered 5%, diatomite adds to 100%, and mixture carries out air-flow crushing, makes 50% Boscalid RH-7592 wetting powder.
Example 30 56% Boscalid RH-7592 water dispersible granules
Boscalid 46%, RH-7592 10%, neopelex 5%, lignosulfonates 5%, ammonium sulfate 1.5%, kaolin add to 100%, mix to make 56% Boscalid RH-7592 water dispersible granules.
Example 31 30% Boscalid RH-7592 suspending agents
Boscalid 25%, RH-7592 5%, polycarboxylate 6%, spaonin powder 4%, silicone oil 0.2%, xanthans 1.2%, triethylene glycol 1.8%, deionized water add to 100%, mix to make 30% Boscalid RH-7592 suspending agent.
Example 32 30% Boscalid RH-7592 suspension emulsions
Boscalid 25%, RH-7592 5%, lignosulfonates 7%, tea are withered 5%, silicone compound 0.4%, crosslinked crospolyvinylpyrrolidone 1.6%, 600# phosphate 6%, poly-triethylene glycol 3%, water add to 100%, the aforementioned formula material is mixed, namely make 30% Boscalid RH-7592 suspension emulsion.
Example 33 36% Boscalid RH-7592 aqueous emulsions
Boscalid 30%, RH-7592 6%, DMF 5%, alkyl biphenyl ether disulfonic acid magnesium salts 6%, butanols 4%, ethylene glycol 3%, C
8～10Aliphatic alcohols 1.5%, deionized water adds to 100%, mixes to make 36% Boscalid RH-7592 aqueous emulsion.
Example 34 20% Boscalid RH-7592 microemulsions
Boscalid 15%, RH-7592 5%, By series 6%, ethylene glycol monomethyl ether 5%, polyethylene glycol 8%, C
8～10Aliphatic alcohols 2%, deionized water adds to 100%, mixes to make 20% Boscalid RH-7592 microemulsion.
Example 35 7% Boscalid RH-7592 suspension seed-coating agents
Boscalid 6%, RH-7592 1%, fatty alcohol-polyoxyethylene ether 5%, naphthalenesulfonateformaldehyde formaldehyde carboxylic compound 4.4%, polyvinyl acetate 2%, triethylene glycol 3%, alkylphenol-formaldehyde resin polyoxy ethyl ether 2.6%, C10～20 saturated fat acids 1.5%, naphthenate 27%, water add to 100%, make 7% Boscalid RH-7592 suspension seed-coating agent through mixing.
Wetting powder the key technical indexes of the present invention:
Table 1
Water dispersible granules the key technical indexes of the present invention:
Table 2
Suspending agent the key technical indexes of the present invention:
Table 3
Suspension emulsion the key technical indexes of the present invention:
Table 4
Aqueous emulsion the key technical indexes of the present invention:
Table 5
Microemulsion the key technical indexes of the present invention:
Table 6
Suspension seed-coating agent the key technical indexes of the present invention:
Table 7
The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.First by Toxicity Determination, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR＜0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect, on this basis, then carry out field trial.
Boscalid and active component B (B be selected from glyoxalin, metconazole, triticonazole, kind bacterium azoles, RH-7592 a kind of) are composite to the crop pest Toxicity Determination.
After the effective inhibition concentration scope of each medicament was determined in prerun, each medicament was established respectively 5 dosage by active constituent content and is processed, and established the clear water contrast.Carry out with reference to " farm-chemical indoor determination test rule bactericide ", adopt the mycelial growth rate method to measure medicament to the virulence of crop germ.Measure colony diameter with the right-angled intersection method after 72h, calculate and respectively process net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates thus the EC of every kind of medicament
50Value.Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method simultaneously, SR＜0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively active component Boscalid and active component B (glyoxalin, metconazole, triticonazole, kind bacterium azoles, RH-7592) shared ratio in combination;
A is Boscalid;
B is a kind of in glyoxalin, metconazole, triticonazole, kind bacterium azoles, RH-7592.
Implementation of an application example two:
Boscalid and glyoxalin are composite to the grey mould fruit rot of strawberry Toxicity Determination.
Test medicine provides by Shanxi Thompson Biological Technology Co., Ltd..
Experimental scheme: determine that through preliminary experiment Boscalid, the former medicine of glyoxalin reach both effective inhibition concentration scopes of different proportioning mixtures.
The toxicity test result
Table 8 Boscalid, glyoxalin and composite toxicity test analysis of results table to grey mould fruit rot of strawberry thereof
As shown in Table 8, Boscalid, the glyoxalin EC to grey mould fruit rot of strawberry
50Be respectively 3.75mg/L and 0.89mg/L.Boscalid and glyoxalin proportioning were at 80: 1 to 1: 60 o'clock, synergy ratio SR is all greater than 1.5, illustrating that Boscalid and glyoxalin were mixed in scope at 80: 1 to 1: 60 all shows synergistic effect, especially when both proportioning during at 15: 1 to 1: 3, synergistic effect is more obviously outstanding, wherein synergy ratio SR is maximum when Boscalid and glyoxalin percentage by weight are 3: 1, and synergistic effect is the most obvious.
Implementation of an application example three:
Boscalid and metconazole are composite to the powdery mildew of cucumber Toxicity Determination.
Test medicine provides by Shanxi Thompson Biological Technology Co., Ltd..
Experimental scheme: determine that through preliminary experiment Boscalid, the former medicine of metconazole reach both effective inhibition concentration scopes of different proportioning mixtures.
The toxicity test result
Table 9 Boscalid, metconazole and composite toxicity test analysis of results table to powdery mildew of cucumber thereof
As shown in Table 9, Boscalid, the metconazole EC to powdery mildew of cucumber
50Be respectively 3.64mg/L and 0.62mg/L.Boscalid and metconazole proportioning were at 80: 1 to 1: 60 o'clock, synergy ratio SR is all greater than 1.5, illustrating that Boscalid and metconazole were mixed in scope at 80: 1 to 1: 60 all shows synergistic effect, wherein synergistic effect is the most remarkable when Boscalid and metconazole proportioning are 20: 1 to 1: 5, especially when the proportioning of Boscalid and metconazole during at 5: 1, synergy ratio SR is maximum, and synergistic effect is the most obvious.
Implementation of an application example four
Boscalid and triticonazole are composite to the wheat rust Toxicity Determination.
Test medicine provides by Shanxi Thompson Biological Technology Co., Ltd..
Experimental scheme: determine that through preliminary experiment Boscalid, the former medicine of triticonazole reach both effective inhibition concentration scopes of different proportioning mixtures.
The toxicity test result
Table 10 Boscalid, triticonazole and composite toxicity test analysis of results table to wheat rust thereof
As shown in Table 10, Boscalid, the triticonazole EC to wheat rust
50Be respectively 3.68mg/L and 0.75mg/L.Boscalid and triticonazole proportioning were at 80: 1 to 1: 60 o'clock, synergy ratio SR is all greater than 1.5, illustrating that Boscalid and triticonazole were mixed in scope at 80: 1 to 1: 60 all shows synergistic effect, wherein synergistic effect is the most remarkable when Boscalid and triticonazole proportioning are 20: 1 to 1: 5, especially when the proportioning of Boscalid and triticonazole during at 5: 1, synergy ratio SR is maximum, and synergistic effect is the most obvious.
Implementation of an application example five
Boscalid is composite to the pear scab Toxicity Determination with kind bacterium azoles.
Test medicine provides by Shanxi Thompson Biological Technology Co., Ltd..
Experimental scheme: determine that through preliminary experiment Boscalid, the former medicine of kind bacterium azoles reach both effective inhibition concentration scopes of different proportioning mixtures.
The toxicity test result
Table 11 Boscalid, kind bacterium azoles and composite toxicity test analysis of results table to pear scab thereof
As shown in Table 11, Boscalid, plant the bacterium azoles to the EC of pear scab
50Be respectively 3.87mg/L and 0.71mg/L.Boscalid and kind bacterium azoles proportioning were at 80: 1 to 1: 60 o'clock, synergy ratio SR is all greater than 1.5, Boscalid is described and plants the bacterium azoles and be mixed in scope at 80: 1 to 1: 60 and all show synergistic effect, wherein synergistic effect is the most remarkable when Boscalid is 20: 1 to 1: 5 with kind bacterium azoles proportioning, especially when Boscalid with the proportioning of planting the bacterium azoles during at 5: 1, synergy ratio SR is maximum, and synergistic effect is the most obvious.
Implementation of an application example six
Boscalid and RH-7592 are composite to the peach brown rot Toxicity Determination.
Test medicine provides by Shanxi Thompson Biological Technology Co., Ltd..
Experimental scheme: determine that through preliminary experiment Boscalid, the former medicine of RH-7592 reach both effective inhibition concentration scopes of different proportioning mixtures.
The toxicity test result
Table 12 Boscalid, RH-7592 and composite toxicity test analysis of results table to peach brown rot thereof
As shown in Table 12, Boscalid, the RH-7592 EC to peach brown rot
50Be respectively 3.85mg/L and 0.76mg/L.Boscalid and RH-7592 proportioning were at 80: 1 to 1: 60 o'clock, synergy ratio SR is all greater than 1.5, illustrating that Boscalid and RH-7592 were mixed in scope at 80: 1 to 1: 60 all shows synergistic effect, wherein synergistic effect is the most remarkable when Boscalid and RH-7592 proportioning are 20: 1 to 1: 5, especially when the proportioning of Boscalid and RH-7592 during at 5: 1, synergy ratio SR is maximum, and synergistic effect is the most obvious.
Application Example seven Boscalids and glyoxalin and the composite control grey mould fruit rot of strawberry test of pesticide effectiveness thereof
This experimental establishment is at the Xian City, Shanxi Province Changan District, and test medicine is researched and developed, provided by Shanxi Thompson Biological Technology Co., Ltd., contrast medicament 50% Boscalid water dispersible granules (commercial), 15% glyoxalin wetting powder (commercial).
The investigation grey mould fruit rot of strawberry state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once is total to dispenser 2 times.Investigated respectively disease index and calculated preventive effect in 7 days, 14 days, 30 days after dispenser for the second time.Experimental result is as follows:
Table 13 Boscalid, glyoxalin and the composite control grey mould fruit rot of strawberry test of pesticide effectiveness thereof
As can be seen from Table 13, can effectively prevent and treat grey mould fruit rot of strawberry after Boscalid and glyoxalin are composite, control efficiency all is better than the preventive effect of single dose, and the preventive effect phase is long.In the test scope of medication, the target crop is had no adverse effects.
Application Example eight Boscalids and the composite seed dressing control of maize of the triazole class compounds disease test of pesticide effectiveness
This experimental establishment is in the Xinxiang City, Henan Province suburb, test medicine is researched and developed, is provided by Shanxi Thompson Biological Technology Co., Ltd., contrast medicament 50% Boscalid water dispersible granules (commercial), 15% glyoxalin wetting powder (commercial), 5% metconazole seed treatment emulsion (commercial), 25 grams per liter triticonazole suspension seed-coating agents (commercial), 25 grams per liter kind bacterium azoles suspension seed-coating agents (commercial), 5% RH-7592 seed dressing (commercial).
Before medicine, the local corn state of an illness of investigation, dress seed by each preparation dosage before sowing.Investigated respectively disease index and calculated preventive effect in 30 days, 50 days after dispenser.Experimental result is as follows:
The composite seed dressing control of maize of table 14 Boscalid and the triazole class compounds disease test of pesticide effectiveness
As can be seen from Table 14, can effectively prevent and treat cucumber disease after Boscalid and triazole class compounds are composite, control efficiency all is better than the preventive effect of single dose, and the preventive effect phase reached more than 50 days.In the test scope of medication, the target crop is had no adverse effects.
Application Example nine Boscalids and metconazole and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Xiangfen County, Linfen, Shanxi Province, and test medicine is researched and developed, provided by Shanxi Thompson Biological Technology Co., Ltd., contrast medicament 50% Boscalid water dispersible granules (commercial), 60 grams per liter metconazole aqueous emulsions (commercial).
The investigation powdery mildew of cucumber state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once is total to dispenser 2 times.Investigated respectively disease index and calculated preventive effect in 3 days, 14 days, 30 days after dispenser for the second time.Experimental result is as follows:
Table 15 Boscalid, metconazole and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 15, can effectively prevent and treat the powdery mildew of cucumber disease after Boscalid and metconazole are composite, control efficiency all is better than the preventive effect of single dose, and the preventive effect phase is long.In the test scope of medication, the target crop is had no adverse effects.
Application Example ten Boscalids and triticonazole and the composite wheat rust test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Xingtai City Nanhe County, Hebei province, and test medicine is researched and developed, provided by Shanxi Thompson Biological Technology Co., Ltd., contrast medicament 50% Boscalid water dispersible granules (commercial), 25 grams per liter triticonazole suspending agents (commercial).
Investigation wheat rust disease index before medicine, in the their early stage dispenser, every dispenser on the 7th once, dispenser is 2 times altogether, for the second time 3 days, 14 days, 30 days investigation disease indexs and calculate preventive effect after dispenser.Experimental result is as follows:
Table 16 Boscalid, the composite wheat rust test of pesticide effectiveness of preventing and treating of triticonazole
As can be seen from Table 16, can effectively prevent and treat wheat rust after Boscalid and triticonazole are composite, control efficiency all is better than the preventive effect of single dose, and the preventive effect phase is long.In the test scope of medication, the target crop is had no adverse effects.
Application Example 11 Boscalids are tested with kind bacterium azoles and the composite pear scab effect of preventing and treating thereof
This experimental establishment is in Runan County, Zhumadian prefecture, Henan province city, and test medicine is researched and developed, provided by Shanxi Thompson Biological Technology Co., Ltd., contrast medicament 50% Boscalid water dispersible granules (commercial), 10% kind of bacterium azole suspending agent (commercial).
Investigation pear scab disease index before medicine, in the their early stage dispenser, dispenser for the second time after 7 days, dispenser is 3 times altogether, for the third time 3 days, 14 days, 30 days investigation disease indexs and calculate preventive effect after dispenser.Experimental result is as follows:
Table 17 Boscalid, kind bacterium azoles and the composite pear scab test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 17, can effectively prevent and treat pear scab after Boscalid is composite with kind bacterium azoles, control efficiency all is better than the preventive effect of single dose, and the preventive effect phase is long.In the test scope of medication, the target crop is had no adverse effects.
Application Example 12 Boscalids and RH-7592 and the composite peach brown rot test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Guangyuan City suburb, Sichuan Province, and test medicine is researched and developed, provided by Shanxi Thompson Biological Technology Co., Ltd., contrast medicament 50% Boscalid water dispersible granules (commercial), 24% RH-7592 missible oil (commercial).
The investigation peach brown rot state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once is total to dispenser 3 times.Investigated respectively disease index and calculated preventive effect in 3 days, 14 days, 30 days after dispenser for the third time.Experimental result is as follows:
Table 18 Boscalid, RH-7592 and the composite peach brown rot test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 18, can effectively prevent and treat peach brown rot after Boscalid and RH-7592 are composite, control efficiency all is better than the preventive effect of single dose, and the preventive effect phase is long.In the test scope of medication, the target crop is had no adverse effects.
Claims (4)
1. bactericidal composition that contains Boscalid and triazole class compounds, it is characterized in that: active component is comprised of A and B, and the weight ratio of A and B is 1:3 ~ 9:1, and described active component A is Boscalid, and active component B is glyoxalin.
2. a kind of bactericidal composition that contains Boscalid and triazole class compounds according to claim 1, it is characterized in that: the formulation of bactericidal composition is selected from: wetting powder, water dispersible granules, suspending agent, suspension emulsion, suspension seed-coating agent, aqueous emulsion or microemulsion.
3. a kind of bactericidal composition that contains Boscalid and triazole class compounds according to claim 1 is used for the application of disease on control grass family class crop, vegetables, ornamental flower and fruit tree.
4. application according to claim 3 is characterized in that: described disease is powdery mildew, gray mold, net blotch, rice blast, anthrachose of grape, glume blight, rust, anthracnose, root rot, rot, brown spot, scab, leaf spot, black spot, shot hole.
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| CN102428931B (en) * | 2011-12-23 | 2013-09-18 | 江阴苏利化学股份有限公司 | Bacteriocidal composition containing Boscalid and triazole bactericide |
| CN103798242B (en) * | 2013-11-19 | 2015-08-12 | 广西田园生化股份有限公司 | Containing the ultra low volume liquids of Boscalid and triazole bactericidal agent |
| CN104186486B (en) * | 2014-09-22 | 2017-01-11 | 江苏省绿盾植保农药实验有限公司 | Sterilizing composition containing fluopicolide and metconazole and application thereof |
| CN106212469A (en) * | 2016-07-13 | 2016-12-14 | 南京吉星生物技术开发有限公司 | A kind of bactericidal composition and application thereof |
| CN105941422B (en) * | 2016-07-13 | 2018-10-30 | 南京吉星生物技术开发有限公司 | A kind of bactericidal composition and its application containing Boscalid |
| GB2552695B (en) * | 2016-08-04 | 2020-03-04 | Rotam Agrochem Int Co Ltd | A synergistic fungicidal composition |
| GB2562082B (en) * | 2017-05-04 | 2021-10-27 | Rotam Agrochem Int Co Ltd | A fungicidal composition and the use thereof |
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| US5556988A (en) * | 1991-11-22 | 1996-09-17 | Basf Aktiengesellschaft | Anilide derivatives and their use for combating botrytis |
| CN1751026A (en) * | 2003-02-14 | 2006-03-22 | 巴斯夫股份有限公司 | Novel crystalline modification of the anhydrate of boscalid |
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