CN102188486B - 一种防治脂肪肝的药物组合物及其制备方法 - Google Patents
一种防治脂肪肝的药物组合物及其制备方法 Download PDFInfo
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Abstract
Description
剂量 | 0g/kg BW | 2.5g/kg BW | 5g/kg BW | 10g/kg BW | 40mg/kg BW(CP) |
动物数(只) | 5 | 5 | 5 | 5 | 5 |
受检***数(个) | 5000 | 5000 | 5000 | 5000 | 5000 |
无钩(个) | 7 | 11 | 8 | 14 | 39 |
无定形(个) | 37 | 45 | 30 | 27 | 231 |
胖头(个) | 41 | 28 | 36 | 51 | 79 |
香蕉头(个) | 1 | 4 | 5 | 2 | 2 |
双头(个) | 0 | 0 | 0 | 0 | 1 |
双尾(个) | 0 | 0 | 0 | 0 | 0 |
尾折叠(个) | 0 | 0 | 0 | 0 | 0 |
***畸形数(个) | 86 | 88 | 79 | 94 | 352 |
***畸形率(%) | 1.72 | 1.76 | 1.58 | 1.88 | 7.04* |
剂量组(g/kg BW) | 动物数(只) | 初始体重(g) | P值 | 终体重(g) | P值 |
0.00(空白) | 10 | 22.0±0.8 | -- | 34.8±2.5 | -- |
0.00(模型) | 10 | 22.0±0.6 | 1.000 | 33.2±1.6 | 0.370 |
0.11 | 10 | 22.1±0.9 | 0.998 | 34.4±2.0 | 0.990 |
0.33 | 10 | 22.0±0.7 | 0.999 | 32.8±1.7 | 0.171 |
1.00 | 10 | 21.9±0.9 | 0.997 | 33.9±3.0 | 0.814 |
剂量(g/kg BW) | 动物数(只) | MDA含量(μmol/g肝) | P值(空白) | P值(模型) |
0.00(空白) | 10 | 0.20±0.02 | -- | -- |
0.00(模型) | 10 | 0.52±0.08## | 0.000 | -- |
0.11 | 10 | 0.46±0.05 | -- | 0.087 |
0.33 | 10 | 0.40±0.08** | -- | 0.001 |
1.00 | 10 | 0.41±0.06** | -- | 0.003 |
剂量(g/kg BW) | 动物数(只) | GSH含量(μmol/g肝) | P值(空白) | P值(模型) |
0.00(空白) | 10 | 6.99±0.76 | -- | -- |
0.00(模型) | 10 | 5.04±0.89## | 0.000 | -- |
0.11 | 10 | 5.31±0.56 | -- | 0.948 |
0.33 | 10 | 5.55±1.63 | -- | 0.937 |
1.00 | 10 | 6.60±1.29* | -- | 0.033 |
剂量(g/kg BW) | 动物数(只) | TG含量μmol/g肝) | P值(空白) | P值(模型) |
0.00(空白) | 10 | 14.75±5.55 | -- | -- |
0.00(模型) | 10 | 94.40±54.04## | 0.001 | -- |
0.11 | 10 | 34.97±22.90* | -- | 0.041 |
0.33 | 10 | 30.14±19.39* | -- | 0.024 |
1.00 | 10 | 32.83±15.81* | -- | 0.031 |
Claims (10)
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CN103285217B (zh) * | 2013-06-14 | 2015-01-14 | 袁军清 | 一种疏肝解毒中药 |
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