CN102167750B - 一种130羟乙基淀粉的制备方法 - Google Patents
一种130羟乙基淀粉的制备方法 Download PDFInfo
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- CN102167750B CN102167750B CN2011100212213A CN201110021221A CN102167750B CN 102167750 B CN102167750 B CN 102167750B CN 2011100212213 A CN2011100212213 A CN 2011100212213A CN 201110021221 A CN201110021221 A CN 201110021221A CN 102167750 B CN102167750 B CN 102167750B
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- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 229920002472 Starch Polymers 0.000 title abstract description 7
- 235000019698 starch Nutrition 0.000 title abstract description 7
- 239000008107 starch Substances 0.000 title abstract description 7
- 239000007788 liquid Substances 0.000 claims abstract description 39
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 28
- 238000000108 ultra-filtration Methods 0.000 claims abstract description 21
- 239000002798 polar solvent Substances 0.000 claims abstract description 5
- 238000006243 chemical reaction Methods 0.000 claims description 34
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 30
- 238000003756 stirring Methods 0.000 claims description 27
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 20
- 239000000243 solution Substances 0.000 claims description 19
- 239000011259 mixed solution Substances 0.000 claims description 15
- 235000014347 soups Nutrition 0.000 claims description 15
- 239000006228 supernatant Substances 0.000 claims description 15
- 239000000047 product Substances 0.000 claims description 11
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims description 10
- 238000010828 elution Methods 0.000 claims description 10
- 150000002500 ions Chemical class 0.000 claims description 10
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 9
- 238000005507 spraying Methods 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 230000007062 hydrolysis Effects 0.000 claims description 6
- 238000006460 hydrolysis reaction Methods 0.000 claims description 6
- 238000001514 detection method Methods 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 5
- 239000012528 membrane Substances 0.000 claims description 5
- 238000006386 neutralization reaction Methods 0.000 claims description 5
- 238000012856 packing Methods 0.000 claims description 5
- 239000008213 purified water Substances 0.000 claims description 5
- 238000011084 recovery Methods 0.000 claims description 5
- 229910001961 silver nitrate Inorganic materials 0.000 claims description 5
- 238000006467 substitution reaction Methods 0.000 claims description 5
- 239000012085 test solution Substances 0.000 claims description 5
- 238000012360 testing method Methods 0.000 claims description 5
- 238000010792 warming Methods 0.000 claims description 5
- 238000000034 method Methods 0.000 abstract description 5
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 239000000463 material Substances 0.000 abstract description 2
- -1 Ethoxyl Chemical group 0.000 abstract 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 238000001914 filtration Methods 0.000 abstract 2
- 230000007547 defect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 12
- 206010013786 Dry skin Diseases 0.000 description 3
- 229920001612 Hydroxyethyl starch Polymers 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 206010021137 Hypovolaemia Diseases 0.000 description 2
- DPDMMXDBJGCCQC-UHFFFAOYSA-N [Na].[Cl] Chemical compound [Na].[Cl] DPDMMXDBJGCCQC-UHFFFAOYSA-N 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 229940050526 hydroxyethylstarch Drugs 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 125000003147 glycosyl group Chemical group 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000003058 plasma substitute Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 229940075601 voluven Drugs 0.000 description 1
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- Polysaccharides And Polysaccharide Derivatives (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
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Priority Applications (1)
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CN2011100212213A CN102167750B (zh) | 2011-01-19 | 2011-01-19 | 一种130羟乙基淀粉的制备方法 |
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CN2011100212213A CN102167750B (zh) | 2011-01-19 | 2011-01-19 | 一种130羟乙基淀粉的制备方法 |
Publications (2)
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CN102167750A CN102167750A (zh) | 2011-08-31 |
CN102167750B true CN102167750B (zh) | 2012-07-25 |
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CN2011100212213A Active CN102167750B (zh) | 2011-01-19 | 2011-01-19 | 一种130羟乙基淀粉的制备方法 |
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CN (1) | CN102167750B (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102344498B (zh) * | 2011-10-26 | 2013-07-17 | 邹平福海科技发展有限公司 | 砂浆专用淀粉醚及其生产方法 |
CN102617743B (zh) * | 2012-03-31 | 2015-02-18 | 李育强 | 一种羟乙基淀粉的制备方法 |
CN102659953B (zh) * | 2012-04-18 | 2016-01-20 | 高旭 | 一种分子量为550万的羟乙基淀粉的制备方法 |
CN103864942B (zh) * | 2012-12-11 | 2016-05-18 | 北大方正集团有限公司 | 中分子量羟乙基淀粉及其提纯方法 |
CN104277126B (zh) * | 2013-07-11 | 2016-08-10 | 北大方正集团有限公司 | 羟乙基淀粉的提纯方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4398024A (en) * | 1980-11-19 | 1983-08-09 | Wolff Walsrode Aktiengesellschaft | Process for the purification of cellulose and starch ethers |
CN1840547A (zh) * | 2005-12-29 | 2006-10-04 | 天津协和生物科技发展有限公司 | 用于不同分子量和不同替代度的羟乙基淀粉的制备方法 |
CN101402690A (zh) * | 2008-09-27 | 2009-04-08 | 杭州民生药业集团有限公司 | 一种制备羟乙基淀粉的方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5160284A (ja) * | 1974-11-25 | 1976-05-26 | Ajinomoto Kk | Sohidorokishechirukadenpunno seiseiho |
AU2005217157B2 (en) * | 2004-03-01 | 2011-05-12 | B. Braun Melsungen Ag | Hydroxyethyl starch |
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2011
- 2011-01-19 CN CN2011100212213A patent/CN102167750B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4398024A (en) * | 1980-11-19 | 1983-08-09 | Wolff Walsrode Aktiengesellschaft | Process for the purification of cellulose and starch ethers |
CN1840547A (zh) * | 2005-12-29 | 2006-10-04 | 天津协和生物科技发展有限公司 | 用于不同分子量和不同替代度的羟乙基淀粉的制备方法 |
CN101402690A (zh) * | 2008-09-27 | 2009-04-08 | 杭州民生药业集团有限公司 | 一种制备羟乙基淀粉的方法 |
Non-Patent Citations (1)
Title |
---|
JP昭51-60284A 1976.05.26 |
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Address after: 100101 No. 2 building, No. 19, Beiyuan East Road, 2508, Beijing, Chaoyang District, 25 Patentee after: BEIJING LUNARSUN PHARMACEUTICAL Co.,Ltd. Address before: 100101 Beijing Chaoyang District Anli Road, Sunshine Plaza, No. 68 room C1-802 Patentee before: BEIJING LUNARSUN PHARMACEUTICAL Co.,Ltd. |
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Effective date of registration: 20191226 Address after: D3-8-2, Erlang international student Pioneer Park, No. 71, 71-1, Kecheng Road, Jiulongpo District, Chongqing 400000 Patentee after: Chongqing Shisen Pharmaceutical Technology Co.,Ltd. Address before: 100101 No. 2 building, No. 19, Beiyuan East Road, 2508, Beijing, Chaoyang District, 25 Patentee before: BEIJING LUNARSUN PHARMACEUTICAL Co.,Ltd. |
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Denomination of invention: A preparation method of 130 hydroxyethyl starch Effective date of registration: 20231008 Granted publication date: 20120725 Pledgee: Bank of China Limited Chongqing Jiulongpo Branch Pledgor: Chongqing Shisen Pharmaceutical Technology Co.,Ltd. Registration number: Y2023500000079 |