CN102060892A - 甜菊糖甙rd的提纯方法 - Google Patents
甜菊糖甙rd的提纯方法 Download PDFInfo
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- CN102060892A CN102060892A CN2010106132701A CN201010613270A CN102060892A CN 102060892 A CN102060892 A CN 102060892A CN 2010106132701 A CN2010106132701 A CN 2010106132701A CN 201010613270 A CN201010613270 A CN 201010613270A CN 102060892 A CN102060892 A CN 102060892A
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- Prior art keywords
- steviosides
- purification
- liquid
- solid
- adsorptive resins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 235000019202 steviosides Nutrition 0.000 title claims abstract description 108
- 238000000034 method Methods 0.000 title claims abstract description 40
- RPYRMTHVSUWHSV-CUZJHZIBSA-N rebaudioside D Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RPYRMTHVSUWHSV-CUZJHZIBSA-N 0.000 title abstract description 16
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 title abstract description 12
- 229940013618 stevioside Drugs 0.000 title abstract description 12
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 title abstract description 12
- 239000007788 liquid Substances 0.000 claims abstract description 45
- 239000011347 resin Substances 0.000 claims abstract description 33
- 229920005989 resin Polymers 0.000 claims abstract description 33
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000007787 solid Substances 0.000 claims abstract description 22
- 238000001035 drying Methods 0.000 claims abstract description 18
- 238000007670 refining Methods 0.000 claims abstract description 13
- 238000010521 absorption reaction Methods 0.000 claims abstract description 8
- 239000011148 porous material Substances 0.000 claims abstract description 8
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000012452 mother liquor Substances 0.000 claims abstract description 6
- 238000000746 purification Methods 0.000 claims description 34
- 230000000274 adsorptive effect Effects 0.000 claims description 20
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 17
- 239000000243 solution Substances 0.000 claims description 14
- 239000012046 mixed solvent Substances 0.000 claims description 13
- 238000000926 separation method Methods 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 9
- 239000011259 mixed solution Substances 0.000 claims description 5
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 238000010828 elution Methods 0.000 claims description 3
- 238000004090 dissolution Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 238000001179 sorption measurement Methods 0.000 abstract description 4
- 239000003480 eluent Substances 0.000 abstract 3
- 229920001577 copolymer Polymers 0.000 abstract 1
- 229930182478 glucoside Natural products 0.000 description 7
- 150000008131 glucosides Chemical class 0.000 description 6
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 241000544066 Stevia Species 0.000 description 5
- 235000009508 confectionery Nutrition 0.000 description 4
- ILRCGYURZSFMEG-UHFFFAOYSA-N Salidroside Natural products OC1C(O)C(O)C(CO)OC1OCCC1=CC=C(O)C=C1 ILRCGYURZSFMEG-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000001476 alcoholic effect Effects 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 238000004587 chromatography analysis Methods 0.000 description 3
- 239000007791 liquid phase Substances 0.000 description 3
- ILRCGYURZSFMEG-RQICVUQASA-N salidroside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1OCCC1=CC=C(O)C=C1 ILRCGYURZSFMEG-RQICVUQASA-N 0.000 description 3
- 239000012266 salt solution Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- CANAPGLEBDTCAF-QHSHOEHESA-N Dulcoside A Natural products C[C@@H]1O[C@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]2O[C@]34CC[C@H]5[C@]6(C)CCC[C@](C)([C@H]6CC[C@@]5(CC3=C)C4)C(=O)O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@H](O)[C@H](O)[C@H]1O CANAPGLEBDTCAF-QHSHOEHESA-N 0.000 description 1
- CANAPGLEBDTCAF-NTIPNFSCSA-N Dulcoside A Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@]23C(C[C@]4(C2)[C@H]([C@@]2(C)[C@@H]([C@](CCC2)(C)C(=O)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)CC4)CC3)=C)O[C@H](CO)[C@@H](O)[C@@H]1O CANAPGLEBDTCAF-NTIPNFSCSA-N 0.000 description 1
- 239000001512 FEMA 4601 Substances 0.000 description 1
- HELXLJCILKEWJH-SEAGSNCFSA-N Rebaudioside A Natural products O=C(O[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)[C@@]1(C)[C@@H]2[C@](C)([C@H]3[C@@]4(CC(=C)[C@@](O[C@H]5[C@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@H](O)[C@@H](CO)O5)(C4)CC3)CC2)CCC1 HELXLJCILKEWJH-SEAGSNCFSA-N 0.000 description 1
- YWPVROCHNBYFTP-UHFFFAOYSA-N Rubusoside Natural products C1CC2C3(C)CCCC(C)(C(=O)OC4C(C(O)C(O)C(CO)O4)O)C3CCC2(C2)CC(=C)C21OC1OC(CO)C(O)C(O)C1O YWPVROCHNBYFTP-UHFFFAOYSA-N 0.000 description 1
- 239000004383 Steviol glycoside Substances 0.000 description 1
- OMHUCGDTACNQEX-OSHKXICASA-N Steviolbioside Natural products O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(O)=O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O OMHUCGDTACNQEX-OSHKXICASA-N 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- JLPRGBMUVNVSKP-AHUXISJXSA-M chembl2368336 Chemical compound [Na+].O([C@H]1[C@@H](O)[C@H](O)[C@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C([O-])=O)[C@@H]1O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]1O JLPRGBMUVNVSKP-AHUXISJXSA-M 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- -1 disaccharide glucoside Chemical class 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- HELXLJCILKEWJH-UHFFFAOYSA-N entered according to Sigma 01432 Natural products C1CC2C3(C)CCCC(C)(C(=O)OC4C(C(O)C(O)C(CO)O4)O)C3CCC2(C2)CC(=C)C21OC(C1OC2C(C(O)C(O)C(CO)O2)O)OC(CO)C(O)C1OC1OC(CO)C(O)C(O)C1O HELXLJCILKEWJH-UHFFFAOYSA-N 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 235000019203 rebaudioside A Nutrition 0.000 description 1
- QRGRAFPOLJOGRV-UHFFFAOYSA-N rebaudioside F Natural products CC12CCCC(C)(C1CCC34CC(=C)C(CCC23)(C4)OC5OC(CO)C(O)C(OC6OCC(O)C(O)C6O)C5OC7OC(CO)C(O)C(O)C7O)C(=O)OC8OC(CO)C(O)C(O)C8O QRGRAFPOLJOGRV-UHFFFAOYSA-N 0.000 description 1
- QSRAJVGDWKFOGU-WBXIDTKBSA-N rebaudioside c Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]1(CC[C@H]2[C@@]3(C)[C@@H]([C@](CCC3)(C)C(=O)O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)CC3)C(=C)C[C@]23C1 QSRAJVGDWKFOGU-WBXIDTKBSA-N 0.000 description 1
- HYLAUKAHEAUVFE-AVBZULRRSA-N rebaudioside f Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)CO1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HYLAUKAHEAUVFE-AVBZULRRSA-N 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- YWPVROCHNBYFTP-OSHKXICASA-N rubusoside Chemical compound O([C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O YWPVROCHNBYFTP-OSHKXICASA-N 0.000 description 1
- 230000011218 segmentation Effects 0.000 description 1
- 229930182488 steviol glycoside Natural products 0.000 description 1
- 235000019411 steviol glycoside Nutrition 0.000 description 1
- 150000008144 steviol glycosides Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- DRSKVOAJKLUMCL-MMUIXFKXSA-N u2n4xkx7hp Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(O)=O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O DRSKVOAJKLUMCL-MMUIXFKXSA-N 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
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- Saccharide Compounds (AREA)
- Seasonings (AREA)
Abstract
Description
Claims (10)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201010613270.1A CN102060892B (zh) | 2010-12-30 | 2010-12-30 | 甜菊糖甙rd的提纯方法 |
US13/977,558 US20140004248A1 (en) | 2010-12-30 | 2011-12-30 | Processes of Purifying Steviol Glycosides |
CA2857085A CA2857085A1 (en) | 2010-12-30 | 2011-12-30 | Processes of purifying steviol glycosides |
PCT/CA2011/001428 WO2012088598A1 (en) | 2010-12-30 | 2011-12-30 | Processes of purifying steviol glycosides |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201010613270.1A CN102060892B (zh) | 2010-12-30 | 2010-12-30 | 甜菊糖甙rd的提纯方法 |
Publications (2)
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CN102060892A true CN102060892A (zh) | 2011-05-18 |
CN102060892B CN102060892B (zh) | 2015-04-15 |
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CN201010613270.1A Active CN102060892B (zh) | 2010-12-30 | 2010-12-30 | 甜菊糖甙rd的提纯方法 |
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Cited By (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102321132A (zh) * | 2011-07-12 | 2012-01-18 | 青岛润浩甜菊糖高科有限公司 | 一种甜菊糖甙rc粗提取物的提纯方法 |
CN102406113A (zh) * | 2011-09-30 | 2012-04-11 | 宁波绿之健药业有限公司 | Ra和rd复配甜菊糖的制备方法 |
WO2012094752A1 (en) * | 2011-01-14 | 2012-07-19 | Glg Life Tech Corporation | Processes of purifying steviol glycosides reb c |
CN102796152A (zh) * | 2012-09-07 | 2012-11-28 | 谱赛科(江西)生物技术有限公司 | 制取高Reb-D甜菊糖甙的方法 |
EP2544538A1 (en) | 2010-03-12 | 2013-01-16 | Purecircle Usa Inc. | High-purity steviol glycosides |
WO2013102793A2 (en) * | 2011-12-09 | 2013-07-11 | Su Zhou Jing Hong Biotech Co., Ltd. | A novel process for the preparation of rebaudioside d and other related naturally occurring sweeteners |
CN103314000A (zh) * | 2010-11-19 | 2013-09-18 | 嘉吉公司 | 使用具有大孔中性吸附树脂的吸附-脱附色谱用于富集衍生自甜叶菊的糖苷组合物中的新蛇菊苷b和/或新蛇菊苷d的方法 |
CN103319550A (zh) * | 2013-07-12 | 2013-09-25 | 兰州理工大学 | 甜叶菊粗品中甜菊糖苷的分离纯化方法 |
CN103709215A (zh) * | 2013-12-31 | 2014-04-09 | 天津北洋百川生物技术有限公司 | 一种从甜菊糖结晶母液糖中提取莱鲍迪甙d的方法 |
CN104159908A (zh) * | 2011-12-09 | 2014-11-19 | 苏州景泓生物技术有限公司 | 一种制备瑞鲍迪甙d和其他相关天然甜味剂新的工艺方法 |
US9402411B2 (en) | 2011-01-28 | 2016-08-02 | Tate & Lyle Ingredients Americas Llc | Stevia blends containing rebaudioside B |
US9474295B2 (en) | 2011-01-28 | 2016-10-25 | Tate & Lyle Ingredients Americas Llc | Purification of Luo Han Guo extract |
CN106072462A (zh) * | 2016-06-08 | 2016-11-09 | 郑书旺 | 利用树脂和复合酶的协同作用改善甜菊糖口感的方法 |
US9609887B2 (en) | 2012-08-01 | 2017-04-04 | Tate & Lyle Ingredients Americas Llc | Sweetener compositions containing monk fruit extract and rebaudiosides A and B |
CN106967133A (zh) * | 2017-03-30 | 2017-07-21 | 湖南华诚生物资源股份有限公司 | 一种从甜菊糖苷精制母液中提取高纯度瑞鲍迪苷d的方法 |
CN107105733A (zh) * | 2014-09-26 | 2017-08-29 | 谱赛科美国股份有限公司 | 甜叶菊成分、生产方法和用途 |
CN107955048A (zh) * | 2017-12-25 | 2018-04-24 | 史迪威生物科技(苏州)有限公司 | 莱鲍迪甙d的分离与纯化工艺 |
CN108467415A (zh) * | 2018-04-23 | 2018-08-31 | 江南大学 | 一种工业甜菊糖结晶母液的纯化方法 |
CN108558966A (zh) * | 2018-01-04 | 2018-09-21 | 常州嘉众新材料科技有限公司 | 一种富集甜菊糖中莱鲍迪苷d的生产方法 |
CN110063257A (zh) * | 2015-01-23 | 2019-07-30 | 谱赛科美国公司 | 甜叶菊新品种及高rd、rm含量甜菊糖苷的制备 |
CN115536715A (zh) * | 2022-08-17 | 2022-12-30 | 浙江天草生物科技股份有限公司 | 一种提取甜叶菊糖苷rd的方法 |
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Cited By (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2544538A1 (en) | 2010-03-12 | 2013-01-16 | Purecircle Usa Inc. | High-purity steviol glycosides |
CN103314000A (zh) * | 2010-11-19 | 2013-09-18 | 嘉吉公司 | 使用具有大孔中性吸附树脂的吸附-脱附色谱用于富集衍生自甜叶菊的糖苷组合物中的新蛇菊苷b和/或新蛇菊苷d的方法 |
EP2640736B1 (en) | 2010-11-19 | 2016-08-31 | Cargill, Incorporated | Method for the enrichment of rebaudioside b and/or rebaudioside d in stevia-derived glycoside compositions using adsorb-desorb chromatography with a macroporous neutral adsorbent resin |
CN103314000B (zh) * | 2010-11-19 | 2018-07-27 | 嘉吉公司 | 使用具有大孔中性吸附树脂的吸附-脱附色谱用于富集衍生自甜叶菊的糖苷组合物中的新蛇菊苷b和/或新蛇菊苷d的方法 |
US11414448B2 (en) | 2010-11-19 | 2022-08-16 | Cargill, Incorporated | Method for the enrichment of rebaudioside b and/or rebaudioside d in stevia-derived glycoside compositions using adsorb-desorb chromatography with a macroporous neutral adsorbent resin |
WO2012094752A1 (en) * | 2011-01-14 | 2012-07-19 | Glg Life Tech Corporation | Processes of purifying steviol glycosides reb c |
US11801402B2 (en) | 2011-01-28 | 2023-10-31 | Tate & Lyle Solutions Usa Llc | Stevia blends containing rebaudioside b |
US10583314B2 (en) | 2011-01-28 | 2020-03-10 | Tate & Lyle Ingredients Americas Llc | Stevia blends containing rebaudioside B |
US10085473B2 (en) | 2011-01-28 | 2018-10-02 | Tate & Lyle Ingredients Americas Llc | Purification of Luo Han Guo extract |
US9402411B2 (en) | 2011-01-28 | 2016-08-02 | Tate & Lyle Ingredients Americas Llc | Stevia blends containing rebaudioside B |
US9474295B2 (en) | 2011-01-28 | 2016-10-25 | Tate & Lyle Ingredients Americas Llc | Purification of Luo Han Guo extract |
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