CN102038937A - External medicament for treating dermatosis and anti-aging and preparation method thereof - Google Patents
External medicament for treating dermatosis and anti-aging and preparation method thereof Download PDFInfo
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- CN102038937A CN102038937A CN200910193037XA CN200910193037A CN102038937A CN 102038937 A CN102038937 A CN 102038937A CN 200910193037X A CN200910193037X A CN 200910193037XA CN 200910193037 A CN200910193037 A CN 200910193037A CN 102038937 A CN102038937 A CN 102038937A
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Abstract
The invention discloses a novel specific external medicament for treating dermatosis and anti-aging. The medicament is prepared from the following raw materials: recombinant human interleukin-12 (a latest scientific biological agent), aloe (a natural plant traditional Chinese medicine), hydrolyzed pearl powder, red sage root, angelica, notoginseng, red phaseolus bean, Semen Coicis, earthworm, jelly fungus, kelp, vinegar and distilled water, saline water or spring water. The preparation method comprises the following steps: carrying out freeze-drying or air-drying, crushing, curing, sterilizing, and preparing based on a certain ratio, wherein the recombinant human interleukin-12 needs to be stored at a low temperature, and can be singly used or be mixed with the natural plant traditional Chinese medicine based on the ratio so as to be prepared into an emulsion, liquid, frost, ointment or facial mask for use. The external medicament provided by the invention has unique prescription and manufacturing method, can achieve the effects of skin whitening and activation, anti-aging, acne removal, freckle removal, wrinkle removal, antibiosis and sun protection, has obvious curative effects on wounds, cuts, burns, scalds, ulcers and other skin damages, is resistant to ultraviolet rays and radiant rays and has the effects of repairing and naturally refreshing the skin damages after chemotherapy and radiotherapy.
Description
The present invention relates to a kind of dermatosis and anti-aging externally-applied medicinal composition for the treatment of, relate to particularly that a kind of to be equipped with vegetable Chinese herbal medicine with up-to-date scientific and technological biological preparation be the treatment dermatosis made of former medicine and anti-aging external used medicine.Medicine for external use Pear Power of the present invention changes skin, wrinkle removal, anti-acne, speckle dispelling, sun-proof, antibiotic effect, evident in efficacy to the damage of skin such as wound, knife injury, burn, scald, ulcer, energy anti-ultraviolet and radiation, the blood circulation promoting and blood stasis dispelling damp eliminating, damage has the effect that the reparation skin is lived again naturally to the skin after chemotherapy, the radiotherapy, is damage of treatment skin and anti-aging specially good effect external used medicine.Evident in efficacy to treatment tinea pedis, the tinea manuum in addition.The invention still further relates to the preparation method of this external used medicine.
The people with age naturally can be old and feeble, ultraviolet can cause the immunosuppressant damage skin of skin histology, radiotherapy, chemotherapy radiation also can cause skin damage, wound, knife injury, scald, burn, open-air skin wound first aid, needing can defying age, antibiotic, blood circulation promoting and blood stasis dispelling, repair skin damage, the external used medicine that allows skin live again naturally fast.People president's acne, furuncle and phyma, acne, the somebody is difficult to cure for many years, the people is old, and skin can form wrinkle, and chloasma is arranged, and skin can follow the string, hair can bleach, how to allow the people old skin keep elasticity, wrinkle removing, whiten, speckle dispelling, anti-acne, anti-human senility, allow skin of face recover young shape and remain youthful forever, be the human target of pursuing always.
The object of the present invention is to provide a kind of dermatosis and anti-aging external used medicine for the treatment of.
Another object of the present invention provides the preparation method of this treatment dermatosis and anti-aging remedy for external use.
Solution of the present invention is to select up-to-date biotechnology product recombinant human interleukin--1 2 for use, be used to prevent that ultraviolet, radiation from penetrating and the damage of naturally-aged to the DNA of epidermis cell, can be by the effect of DNA repairase, repair the DNA of the skin that has damaged, keep the normal condition of epidermal tissue.Ultraviolet and radiation and naturally-aged all can cause the immunosuppressant of skin histology, recombinant human interleukin--1 2 has the nucleotide excision repair function, and can remove the cyclobutane pyrimidine dimer that induction of immunity suppresses, promote and keep the immunization of skin.While, achieves with reference to modern pharmacological research sick pathogenetic understanding of skin and Therapeutic Principle based on motherland's medical science; From motherland's medicine treasure-house, filter out Aloe, hydrolyzed pearl powder, Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Angelicae Sinensis, Semen Coicis, Semen Phaseoli, Lumbricus, Auricularia, Thallus Laminariae (Thallus Eckloniae), vinegar, spring water has moistening, antiphlogistic antibacterial, granulation promoting, sun-proof speckle dispelling, anti-acne, anti-ultraviolet and x-ray radiation effect, and has blood circulation promoting and blood stasis dispelling simultaneously, promoting blood circulation, improve cardiovascular function, the blood circulation promoting and enriching Shujin, brighten, microcirculation improvement, the expansion blood capillary, suppress hematoblastic gathering, the toxin expelling damp eliminating, regulate function of nervous system and improve the DNA repair ability, slow down the body resistance strengthening and constitution consolidating of the aging effect of organ-tissue, the homologous natural edible-plant medicine of medicated diet.By the theory of Chinese medical science prescription, skim the cream off milk.
Medicine of the present invention is made by following component: (consumption is a weight portion)
Formula optimization weight (part) ratio range of preparation medicine of the present invention is:
The optimum weight of external used medicine of the present invention (part) proportioning is:
The production method that above-mentioned each component is made external used medicine of the present invention is:
1, getting Folium Aloe juice earlier uses after the delead PROCESS FOR TREATMENT;
2, get Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Angelicae Sinensis, Semen Coicis, Semen Phaseoli, Lumbricus, Thallus Laminariae (Thallus Eckloniae), Auricularia, be ground into 120 order fine powders after air-dry, can adopt nanotechnology technology.
3, with above-mentioned whole powder components by after the described mixed, add Aloe juice and hydrolyzed pearl powder and under 100 ℃～110 ℃, carried out the ripening sterilization treatment 15～35 minutes.
4, add spring water, vinegar or saline in proportion according to making Emulsion, liquor, frost or unguentum demand.
5, the suitable cryopreservation of recombinant human interleukin--1's 2 biological agents is put in the refrigerator, can first separately usefulness, and also can add Chinese medicinal plant and be mixed in Emulsion, liquor, frost or unguentum and the facial film and use.
An important feature of the present invention is to contain abundant nutrition in the topical agent, wherein contain multiple proteins, natural vitamin (A, B, C, D, E) etc. 16 seed amino acids are arranged, leucine, methionine, alanine, glycine, glutamic acid, aspartic acid, recombinant human interleukin--1 2 innovates efficiently the biological activity raw material can allow skin repair naturally to live again, can prevent because of ultraviolet, radiation and naturally-aged are to the damage of the DNA of epidermis cell, can be by effect to the DNA repairase, repair the DNA of the skin that has damaged, keep the normal condition of epidermal tissue.Make skin pure white, fine and smooth, springiness.Prevent the generation of the coarse and wrinkle of skin.In addition, Thallus Laminariae (Thallus Eckloniae), aloin, anthraquinone, cinnamic acid fat have certain insulating effect to ultraviolet.
In addition, contain aloin, glycocide, enzyme resin, emodin and anthraquinone, cinnamic acid fat and mineral in treatment dermatosis of the present invention and the anti-aging therapeutic agent topical agent, total tanshinones etc. are that treatment sunburn dermatitis, skin are dry, the good medicine of wound, ulcer, can make the hair smooth pliable, the skin delicacy is pure white, and the curative effect of skin damage is splendid after processing wound and burn, scald, radiotherapy, the chemotherapy.Grain-negative, positive bacteria all there be stronger killing and inhibitory action, dermatophytess such as epidermophyton inguinale, epidermophyton rubrum, star-shaped nocardia are had suppress effect in various degree.Total tanshinone is to 8 kinds of penicillin resistants, streptomycin and chlortetracycline and the anti-erythromycin of 50 strains, staphylococcus aureus sensitivity.Arthroncus due to TANSHINONES is dyed Ovum Gallus domesticus album, chondrus ocellatus Holmes colloidality, dextran, formaldehyde and bacterium liquid inductance simultaneously all has tangible antiinflammatory action.
Another important feature of the present invention be contain algae and earth-worm extractive as raw material, cryptotanshinone, Tanshinone I and Tanshinone I I and tens kinds of monomer components and danshensu in the topical agent can blood circulation promoting and blood stasis dispelling, promoting blood circulation, speckle removing, external thrombus is formed, platelet aggregation and coagulation function all have inhibitory action, danshensu can suppress myocardial ischemia, and algae has can the blood circulation promoting function.Penetration and dissolving power with height, the new life of pair cell has effect, can resist oxidation, catabiosis, contained abundant iodine of algae and water solublity mucus, can promote thyroid, the metabolism of hormonal secretion and cell, prevention xerosis cutis and wrinkle, the generation of black speck, pH value is weakly acidic algae, in the energy and the acid-base value of skin, is rich in the vitamin C melanin that can go down, the nutrition recuperating oiliness, dryness, the sensitivity skin, and blood circulation promoting, maintain the bright profit of skin gloss, algae has disinfective action, can remove the dirt of sweat gland and sebaceous gland, the molecular compound of its transparence can be removed the dirt in the pore, makes dermal respiration unimpeded.The blood vessel of old and feeble skin reduces relatively, and skin microcirculation weakens, the blood vessel wall attenuation, and parietal cell reduces, and has reduced tissue perfusion and oxidizing process, and it is withered dim complexion to occur, and skin metabolism desired nutritional composition can not be provided, and brings out wrinkle and produces.Earth-worm extractive as raw material has the function of microcirculation improvement, the effectively aging of delaying skin, and expansible blood capillary suppresses hematoblastic gathering.Can also promote the ability of fibroblasts proliferation and synthetic collagen.Simultaneously, the human body immunity improving function promotes aged cells regeneration, repairs damaged cell, fundamentally improves the physiological function of old and feeble skin.
Another important feature in addition of the present invention is to have adjusting function of nervous system in this topical agent.Enrich blood and invigorate blood circulation, convergence, granulation promoting, promotion tissue regeneration, strengthen the vigor of ATP enzyme, can promote that skin is delicate, promote skin health and improve the DNA repair ability, and the restraint of tyrosinase activity is arranged, prevent that the tyrosine oxidation from forming the pigment effect.Can treat chloasma, freckle, pigmentation disease etc., function of nervous system is not normal to be a large amount of neurocyte atrophy death of one of old and feeble important symbol, cause old people's thinking, memory ability goes down, it is aging that kidney-nourishing and essence-enriching herb can improve old people's nervous system, reduce lipofuscin deposition and neuronic forfeiture in the cerebral tissue, simultaneously, can make sympathetic nerve and parasympathetic activity be tending towards normal, the smart medicine of the big kidney benefit of balance and adjusting can promote liver, kidney, DNA in the human tissue organ such as spleen and brain, RNA and proteinic biosynthesis, improve the synthetic level of the non-program of periphery lymphocyte DNA that the old people reduces, and dna profiling had activation, archaeal dna polymerase to external different tissue sources has the obvious suppression effect, thereby improve the DNA repair ability, the aging that slows down organ-tissue.For life age that can prolonged human lays the foundation, distribute according to people's acupuncture point with topical agent of the present invention and to adhere to smearing every day the acupuncture point, just can be anti-aging, the life age of prolonged human dreams of that with messenger work was not impossible realize by 150～200 years old.Semen Coicis, Semen Phaseoli can be strengthened the function that damp eliminating removes pox in addition, and the enhancing human body immunity function has hypoglycemic activity, and the substance metabolism functions of improvement is arranged, and vinegar has vessel softening, the effect of cholesterol reducing and beauty treatment, blood pressure lowering hair growth promoting.
The clinical use result of topical agent of the present invention shows that following advantage is arranged:
1, to select for use 2 pairs of recombinant interleukin-1s to repair fast raw material of biological activity efficiently and the natural edible-plant Chinese medicine of skin damage curative effect be raw material in the present invention, each component meets the pharmaceutical control law regulation, utilize up-to-date scientific and technological biological preparation and the comprehensive function of Chinese medicine of respectively distinguishing the flavor of anti-aging, treatment skin injury and complication thereof, fast evident in efficacy the having no adverse reaction of effect, nontoxic to human body.
2, the present invention need not be oral, have an injection, only be used for human body skin and smear, utilize nanotechnology to natural plants Chinese medicine processed after, make in the more direct infiltration skin of its composition, easy to use, safe, meet national medicine for external use health legislation regulation.
3, the present invention uses comprehensive prescription application method, and therapeutic effect is obviously increased, and can significantly prevent untoward reaction, reaches the purpose for the treatment of both the principal and the secondary aspects of a disease at the same time, to the work to 150 of the anti-aging dream of the mankind～" hope " laid the first stone in 200 years old.
4, topical agent of the present invention can replace expensive operation, the method for skin is changed in surgery injection beauty treatment, and reaches the effect of natural beauty.
Of the present invention anti-aging, whiten change that skin, anti-acne, speckle dispelling, wrinkle removal are antibiotic, sun-proof, the topical agent of the effect of anti-ultraviolet and radiation, to 3～7 days visible produce effects examples 10 of acne, furuncle and phyma, acne of stubbornness, to 2～4 days visible produce effects examples 15 of slight comedo; Change skin to whitening and saw produce effects in 3～6 months, whiten fully after 12 months and change skin example 5, knife injury, burn, scald be coated with the medicine for external use frost can alleviate pain, recover skin epidermis effect example 10 evident in efficacy, to smear chemotherapy after chemotherapy, the radiotherapy, the radiotherapy position can alleviate pain, prevent skin ulceration, repair the skin good effect example 20 that took effect in 3 days.
Chloasma, freckle, pigmentation were seen produce effects in 3～6 months, whiten fully after 12 months and change skin example 2, tinea pedis, the tinea manuum were seen produce effects example 20 in 3 days, the miliaria erythra was seen produce effects example 5 in 3～7 days.Be coated with of the damage of topical agent film energy shielding of ultraviolet before the sun-proof important affair of field work, prevent blackening protection skin-whitening example 2 exposure portion.Anti-aging prolongation life age is just being remained clinical verification.
Embodiment
Take by weighing raw material by following proportioning:
Production method is as follows:
Getting Aloe juice earlier uses after the delead PROCESS FOR TREATMENT; Get Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Angelicae Sinensis, Semen Coicis, Semen Phaseoli, Lumbricus, Thallus Laminariae (Thallus Eckloniae), Auricularia and be ground into 120 order fine powders after air-dry, can adopt nanotechnology technology.With above-mentioned whole powder components by after the described mixed, add Aloe juice and hydrolyzed pearl powder and under 100 ℃～110 ℃, carried out the ripening sterilization treatment 15～35 minutes, according to making Emulsion, liquor, frost or unguentum demand, add spring water, vinegar or saline preparation in proportion.The suitable cryopreservation of recombinant human interleukin--1's 2 biological preparation, put in the refrigerator, can smear earlier during use and re-use natural plants Chinese medicine liquor behind the skin and smear same position, also can add to be mixed in the medicament in Emulsion, liquor, frost or unguentum and the facial film in the natural plants and use, product also should be placed in the refrigerator.
Claims (8)
1. treat dermatosis and anti-aging external used medicine for one kind, it is characterized in that it is Emulsion, liquor and frost, unguentum and the facial film of being made by the following weight proportion raw material.
2. treatment dermatosis according to claim 1 and anti-aging external used medicine, wherein the weight proportion of each raw material is:
3. treatment dermatosis according to claim 1 and anti-aging external used medicine, wherein the weight proportion of each raw material is:
4. according to claim 1,2 or 3 described treatment dermatosis and anti-aging external used medicines, it is characterized in that said topical agent is a said dosage form on any pharmaceutics.
5. treatment dermatosis according to claim 4 and anti-aging external used medicine; It is characterized in that said topical agent is Emulsion, liquor, cream, unguentum and facial film.
6. the preparation method of described treatment dermatosis of claim 5 and anti-aging external used medicine, after it is characterized in that getting earlier aloe liquid delead PROCESS FOR TREATMENT, with Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Angelicae Sinensis, Semen Coicis, Semen Phaseoli, Lumbricus, Thallus Laminariae (Thallus Eckloniae), Auricularia drying and crushing to 120 order fine powder, can adopt the nanotechnology processes, above-mentioned whole powder adding aloe liquids and hydrolyzed pearl powder are divided by after the described mixed, under 100 ℃～110 ℃ temperature, carry out ripening, sterilization treatment made powder in 15～35 minutes, then with vinegar, distilled water, spring water or saline are made into Emulsion, liquor, cream, unguentum and facial film.
7. the preparation method of dermatosis and anti-aging external used medicine Emulsion, liquor, cream, unguentum and facial film is treated in smelting according to claim 6, ripening disinfecting action wherein is to adopt staged cooling ripening sterilization, temperature is raised to 110 ℃ rapidly, segmentation drops to 100 ℃ then, and ripening, sterilization time are 15～35 minutes.
8. the preparation method of Emulsion, liquor, cream, unguentum and the facial film of treatment dermatosis according to claim 7 and anti-aging external used medicine, ripening disinfecting action wherein is to be incubated 15 minutes with what mix down at 110 ℃, and then cool to 105 ℃, kept 5 minutes, cool to 100 ℃ again, kept 20 minutes.
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| CN102525866A (en) * | 2012-01-11 | 2012-07-04 | 山东大学威海分校 | Cosmetic additive, and preparation method and application thereof |
| CN103120729A (en) * | 2013-02-28 | 2013-05-29 | 江苏丹晟生物科技有限公司 | Traditional Chinese medicine composition for treating whelk and acne rosacea, and preparation method of total tanshinones |
| CN105920119A (en) * | 2016-04-29 | 2016-09-07 | 丽水市人民医院 | Traditional She medicine for treating skin injury and application method thereof |
| CN106727115A (en) * | 2016-12-13 | 2017-05-31 | 广东科玮生物技术股份有限公司 | A kind of face cream repaired for hyperplastic scar and preparation method thereof |
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| CN102525866B (en) * | 2012-01-11 | 2013-07-10 | 山东大学威海分校 | Cosmetic additive, and preparation method and application thereof |
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| CN103120729A (en) * | 2013-02-28 | 2013-05-29 | 江苏丹晟生物科技有限公司 | Traditional Chinese medicine composition for treating whelk and acne rosacea, and preparation method of total tanshinones |
| CN105920119A (en) * | 2016-04-29 | 2016-09-07 | 丽水市人民医院 | Traditional She medicine for treating skin injury and application method thereof |
| CN106727115A (en) * | 2016-12-13 | 2017-05-31 | 广东科玮生物技术股份有限公司 | A kind of face cream repaired for hyperplastic scar and preparation method thereof |
| CN107375906B (en) * | 2017-07-28 | 2018-06-08 | 广东科玮生物技术股份有限公司 | A kind of scar repair agent and preparation method thereof |
| CN107375906A (en) * | 2017-07-28 | 2017-11-24 | 广东科玮生物技术股份有限公司 | A kind of scar repair agent and preparation method thereof |
| CN108079276A (en) * | 2017-12-07 | 2018-05-29 | 常州市天宁区鑫发织造有限公司 | A kind of preparation method for scar topical agent of dispelling |
| CN108969508A (en) * | 2018-09-21 | 2018-12-11 | 珠海汉盈科技有限公司 | The spontaneous hotting mask of promotion burn wound reparation containing aloe extract |
| CN109010802A (en) * | 2018-09-21 | 2018-12-18 | 珠海汉盈科技有限公司 | The spontaneous hotting mask of promotion burn wound reparation containing Salvia root P.E |
| CN109157652A (en) * | 2018-09-21 | 2019-01-08 | 珠海汉盈科技有限公司 | The spontaneous hotting mask of promotion burn wound reparation containing Radix Arnebiae extract |
| CN113476586A (en) * | 2021-07-08 | 2021-10-08 | 神究富硒农业发展(山东)有限公司 | Preparation method of selenium-rich cell repair liquid |
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| C41 | Transfer of patent application or patent right or utility model | ||
| CB03 | Change of inventor or designer information |
Inventor after: Chen Songbin Inventor before: Zhang Zhiqun |
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| COR | Change of bibliographic data | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20161025 Address after: 510730 Guangzhou Province, free trade zone, Guangdong Avenue, No. 301, room 39 Patentee after: Guangdong Kewei Biological Technology Co., Ltd. Address before: 511442 Guangdong Province, Guangzhou City Southern towns Panyu District Southern China Biguiyuan Chui Street No. 8 Yuanyi Patentee before: Zhang Zhiqun |