CN104224849A - Radiotherapeutic skin-care agent and preparation method thereof - Google Patents
Radiotherapeutic skin-care agent and preparation method thereof Download PDFInfo
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- CN104224849A CN104224849A CN201410484383.4A CN201410484383A CN104224849A CN 104224849 A CN104224849 A CN 104224849A CN 201410484383 A CN201410484383 A CN 201410484383A CN 104224849 A CN104224849 A CN 104224849A
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Abstract
The invention discloses a radiotherapeutic skin-care agent and a preparation method thereof, belongs to the technical field of medical care, and is externally-used skin cream for preventing and treating radiotherapeutic complications. The radiotherapeutic skin-care agent is mainly prepared from propolis, sea buckthorn oil and lecithin by a new pharmaceutical technology. The radiotherapeutic skin-care agent has the beneficial effects as follows: through percutaneous absorption, effects of improving human immunity, resisting inflammation, resisting allergy, resisting oxidation, eliminating free radicals and regulating internal secretion and other systemic effects can be achieved; through local nutrition and healthcare, skin is delicate, is improved in elasticity and is more smooth, the skin and hair protection capacity is improved, and skin inflammation and ulcer caused by radiotherapeutic complications are restored; the radiotherapeutic skin-care agent also has the skin-care and burn-treating effects and the like.
Description
Technical field
The present invention relates to a kind of radiotherapy skin-care agent and preparation method thereof, belong to medical and health preparing technical field.
Technical background
The tumor patient of about 70% needs to accept radiotherapy clinically.Radiodermatitis, ulcer occurrence rate in tumor radiotherapy is very high, and without good way.Therefore prevent and treat radiodermatitis, radiation injury is the task of top priority.Lonizing radiation also produce biological effect to normal structure while tumor cytotoxicity, and clinical manifestation is mucocutaneously occur erythema, dry, moist reaction, ulcer etc.Radiation skin injury is different from general inflammation, burn and ulcer.Lonizing radiation directly act on skin and deep tissue cell thereof, and gradual regression and necrosis occur, and the delay time is long, the extensive fibrosis of final formation.Cause the infringement of blood capillary and thin vessels endotheliocyte simultaneously, produce endovasculitis, cause intimal thickening, the ischemia such as luminal stenosis, obturation or thrombosis sexually revise, therefore it is downright bad in Progressive symmetric erythrokeratodermia, once downright bad and ulcer, be difficult to the new life of the formation of unsoundness granulation tissue and vasoganglion, thus the probability of spontaneous recovery is very little.Radiation skin injury has a strong impact on the quality of life of patient, brings great misery to patient.Existing Therapeutic Method is the symptomatic treatments such as skin moistening, radioprotective mostly, and effect is undesirable.For its pathogenesis, the present invention is for developing a kind of Novel radiation treatment skin-care agent and preparation method thereof.
Summary of the invention
The object of the invention is the deficiency existed for prior art, provides a kind of radiotherapy skin-care agent and preparation method thereof.
The present invention is a kind of skin, mucosa external-application cream, and main component is propolis, Fructrs Hippophae seed oil, lecithin.Propolis is the resinous matter gathered from collagen plant innovation plumule or alabastrum by Apis, and mixing its mandibular gland and wax gland secretions, is biosynthetic active substance, is described as " purple gold " by scientist.Propolis contains more than 30 kind of flavone compound, multiple terpenes, 20 several amino acids, multivitamin and active enzyme, 34 kinds of necessary trace element of human body and polysaccharide, therefore much useful effect is had to human body, body immunity, activating cell, removal toxin, antiinflammatory, antiallergic, antioxidation can be strengthened, scavenging free radicals, slow down aging, endocrine regulation, promotes tissue regeneration effect.Skin is protected by nutrition.Skin can be made fine and smooth, and elasticity increases, ulcer repair; The Fructrs Hippophae seed oil extracted in Fructus Hippophae is rich in VE, carotene, carotenoid, cupreol, unsaturated fatty acid etc., body metabolism can be promoted, be conducive to the organized renewing damaged, also can stop the development of subcutaneous tissue inflammation, antiinflammatory granulation promoting, and significantly promote ulcer healing effect.Thus Fructrs Hippophae seed oil clinically to radiation damage, burn, scald, decubital ulcer, dermatitis, mucositis, etc. have good curative effect, Fructrs Hippophae seed oil external still has better effects to treatment chloasma, chronic skin ulcer; The lecithin extracted by Semen sojae atricolor is described as " the 3rd nutrient " arranged side by side with protein, vitamin by expert, can promote blood circulation, improve serum matter, removes
peroxide.Lecithin is the indispensable material of each cell of human body, if lacked, will reduce the regeneration capacity of Skin Cell, cause pachylosis, has wrinkle.Skin picked-up lecithin increases skin regeneration vigor, adds the good hydrophilic of lecithin and lipophile, makes skin more moist.Inositol contained by lecithin or the main nutrient of hair, can suppress alopecia of losing hair or feathers, fur protective capacities is strengthened.For preventing radiodermatitis, radiation ulcer has unique curative effect.Also can be used for skin nursing and burn.
The concrete composition and ratio (being as the criterion to prepare 1000 grams of a kind of radiotherapy skin-care agents and preparation method thereof) of a kind of radiotherapy skin-care agent and preparation method thereof comprises following related components: propolis 5-100 gram of Fructrs Hippophae seed oil 30-150 milliliter glyceryl monostearate 30-180 gram of lecithin 1-15 gram of glycerol 50-150 milliliter Ethyl Hydroxybenzoate 0.5-10 gram of triethanolamine 5-30 milliliter 95% ethanol 10-100 ml distilled water 300-800 milliliter.
Prove through repetition test, when propolis is lower than 5 grams, in product of the present invention, promote tissue regeneration, antiinflammatory, antipruritic, pain relieving, hemostasis, nutrition protection skin effect are not obvious.Restrain higher than 100 and into quality firmly, inconvenience is embrocated.Fructrs Hippophae seed oil is not obvious lower than 30 milliliters of curative effects, does not become cream higher than 180 milliliters of systems.Lecithin is lower than 1 gram, and skin regeneration ability, increases higher than 15 grams of costs, lose Accessory Effect.Therefore, best composition and ratio of the present invention is as the criterion to prepare 1000 grams of radiotherapy skin-care agents: propolis 10 grams of Fructrs Hippophae seed oil 60 milliliters of glyceryl monostearates 110 grams of lecithin 9 grams of glycerol 90 milliliters of Ethyl Hydroxybenzoates 1 gram of triethanolamine 10 milliliter of 95% ethanol 50 ml distilled water 710 milliliters.
Detailed description of the invention
The preparation method of the radiotherapy skin-care agent belonging to the present invention is characterized in that comprising with bottom rapid:
(1) get propolis 10 grams freezing 30 minutes, be ground into fine grained.
(2) with 95% ethanol 50 milliliters dissolving (1) granule 72 hours, grind for subsequent use.
(3) by Oleum Hippophae 60 milliliters, 9 grams, lecithin, glycerol 90 milliliters is mixed and joins in (2) as oil phase.
(4) will fill after distilled water 710 ml container puts in water-bath and be heated to 90 degree, when dropping to 70 degree of water temperatures, add glyceryl monostearate 110 grams, Ethyl Hydroxybenzoate 1 gram, triethanolamine 10 milliliters is adjusted all, makes aqueous phase.
(5) by 70 degree Celsius for (4) temperature control (temperature is unsuitable too high), (3) oil phase joins in aqueous phase by gradation, stirring and emulsifying, (note: add a small amount of at every turn, abundant stirring, after emulsifying completely, gradation slowly adds again, abundant stirring and emulsifying).
(6) after emulsifying completes, shift out water bath, under continuing to be stirred to room temperature, namely obtain product of the present invention.
(7) fill, often props up 10 grams, sealing.
(8) finished product is homogeneous, and fine and smooth, color and luster is pale brown, easily applies.
(9) purposes: nursing skin, prevents and treats radiodermatitis, burns and ulcer.
(10) usage: external, dab skin, every day 1-2 time.
The present invention compared with prior art has the following advantages:
1. topical application Be very effective of the present invention, is namely improved general immunity by Transdermal absorption, blood circulation promoting and blood stasis dispelling, removes toxin, antiinflammatory, antiallergic, antioxidation, scavenging free radicals, endocrine regulation, promotes tissue regeneration, repair.
2. adopt health-care good product, do not have poisonous side effect of medicine, medical safe is reliable, is suitable for combined therapy of tumour
3. the present invention not only prevents and treats tumor radiotherapy complication, to dermatitis, eczema and burn and scald Be very effective, is also beauty and skin care good merchantable brand.
Claims (2)
1. radiotherapy skin-care agent and preparation method thereof, is characterized in that the raw material making effective ingredient consists of: be as the criterion to prepare 1000 grams of radiotherapy skin-care agents
Propolis 5-100 gram of Fructrs Hippophae seed oil 30-150 milliliter glyceryl monostearate 30-180 gram of lecithin 1-15 gram of glycerol 50-150 milliliter Ethyl Hydroxybenzoate 0.5-10 gram of triethanolamine 5-30 milliliter 95% ethanol 10-100 ml distilled water 300-800 milliliter.
2. radiotherapy skin-care agent and preparation method thereof, is characterized in that the raw material the best making effective ingredient consists of: be as the criterion to prepare 1000 grams of radiotherapy skin-care agents
Propolis 10 grams of Fructrs Hippophae seed oil 60 milliliters of glyceryl monostearates 110 grams of lecithin 9 grams of glycerol 90 milliliters of Ethyl Hydroxybenzoates 1 gram of triethanolamine 10 milliliter of 95% ethanol 50 ml distilled water 710 milliliters.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410484383.4A CN104224849A (en) | 2014-09-22 | 2014-09-22 | Radiotherapeutic skin-care agent and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410484383.4A CN104224849A (en) | 2014-09-22 | 2014-09-22 | Radiotherapeutic skin-care agent and preparation method thereof |
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| CN104224849A true CN104224849A (en) | 2014-12-24 |
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| CN201410484383.4A Pending CN104224849A (en) | 2014-09-22 | 2014-09-22 | Radiotherapeutic skin-care agent and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105079064A (en) * | 2015-07-30 | 2015-11-25 | 无限极（中国）有限公司 | Traditional Chinese medicine extract and preparation method and application thereof |
| CN114015284A (en) * | 2021-11-15 | 2022-02-08 | 江苏义倍医疗科技股份有限公司 | Ink for special positioning pen for radiotherapy for preventing wet skin and preparation method thereof |
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| CN1260170A (en) * | 1999-01-12 | 2000-07-19 | 内蒙古宇航人化妆品有限责任公司 | Seabuckthorn essence concentrate |
| CN101590006A (en) * | 2009-05-23 | 2009-12-02 | 内蒙古宇航人化妆品有限责任公司 | The frozen type skin cosmetic of the composite Oleum Hippophae of a kind of bee product |
| JP2013169153A (en) * | 2012-02-17 | 2013-09-02 | Shefco Co Ltd | Hydrogen-containing drink including functional ingredient |
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2014
- 2014-09-22 CN CN201410484383.4A patent/CN104224849A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1260170A (en) * | 1999-01-12 | 2000-07-19 | 内蒙古宇航人化妆品有限责任公司 | Seabuckthorn essence concentrate |
| CN101590006A (en) * | 2009-05-23 | 2009-12-02 | 内蒙古宇航人化妆品有限责任公司 | The frozen type skin cosmetic of the composite Oleum Hippophae of a kind of bee product |
| JP2013169153A (en) * | 2012-02-17 | 2013-09-02 | Shefco Co Ltd | Hydrogen-containing drink including functional ingredient |
Non-Patent Citations (3)
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| 庞杰: "《美容功能食品与食疗》", 31 January 2005, 化学工业出版社 * |
| 王养正等: "沙棘果油及沙棘籽油对大鼠放射性皮肤损伤的影响", 《西安交通大学学报》 * |
| 陈正行等: "《食品添加剂新产品与新技术》", 31 August 2002, 江苏科学技术出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105079064A (en) * | 2015-07-30 | 2015-11-25 | 无限极（中国）有限公司 | Traditional Chinese medicine extract and preparation method and application thereof |
| US10675308B2 (en) | 2015-07-30 | 2020-06-09 | Infinitus (China) Company Ltd. | Chinese medicine extract and preparation method and application thereof |
| CN114015284A (en) * | 2021-11-15 | 2022-02-08 | 江苏义倍医疗科技股份有限公司 | Ink for special positioning pen for radiotherapy for preventing wet skin and preparation method thereof |
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Application publication date: 20141224 |
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