CN102038937B - External medicament for treating dermatosis and anti-aging and preparation method thereof - Google Patents
External medicament for treating dermatosis and anti-aging and preparation method thereof Download PDFInfo
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- CN102038937B CN102038937B CN200910193037.XA CN200910193037A CN102038937B CN 102038937 B CN102038937 B CN 102038937B CN 200910193037 A CN200910193037 A CN 200910193037A CN 102038937 B CN102038937 B CN 102038937B
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- Medicines Containing Plant Substances (AREA)
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Abstract
The invention discloses a novel specific external medicament for treating dermatosis and anti-aging. The medicament is prepared from the following raw materials: recombinant human interleukin-12 (a latest scientific biological agent), aloe (a natural plant traditional Chinese medicine), hydrolyzed pearl powder, red sage root, angelica, notoginseng, red phaseolus bean, Semen Coicis, earthworm, jelly fungus, kelp, vinegar and distilled water, saline water or spring water. The preparation method comprises the following steps: carrying out freeze-drying or air-drying, crushing, curing, sterilizing, and preparing based on a certain ratio, wherein the recombinant human interleukin-12 needs to be stored at a low temperature, and can be singly used or be mixed with the natural plant traditional Chinese medicine based on the ratio so as to be prepared into an emulsion, liquid, frost, ointment or facial mask for use. The external medicament provided by the invention has unique prescription and manufacturing method, can achieve the effects of skin whitening and activation, anti-aging, acne removal, freckle removal, wrinkle removal, antibiosis and sun protection, has obvious curative effects on wounds, cuts, burns, scalds, ulcers and other skin damages, is resistant to ultraviolet rays and radiant rays and has the effects of repairing and naturally refreshing the skin damages after chemotherapy and radiotherapy.
Description
The present invention relates to and a kind ofly treat dermatosis and anti-aging externally-applied medicinal composition, particularly relate to that a kind of to be equipped with vegetable Chinese herbal medicine with up-to-date scientific and technological biological preparation be the treatment dermatosis made of former medicine and anti-aging external used medicine.Medicine for external use of the present invention has whitening and changes skin, wrinkle removal, anti-acne, speckle dispelling, sun-proof, antibiotic effect, evident in efficacy to skin damages such as wound, knife injury, burn, scald, ulcer, energy anti-ultraviolet and radiation, blood circulation promoting and blood stasis dispelling damp eliminating, having the effect of repairing skin and naturally living again to the skin damage after chemotherapy, radiotherapy, is the damage for the treatment of skin and anti-aging specific external-use medicament.Evident in efficacy to treatment tinea pedis, the tinea manuum in addition.The invention still further relates to the preparation method of this external used medicine.
People with age naturally can be old and feeble, ultraviolet can cause the immunosuppressant damage skin of skin histology, radiotherapy, chemotherapy radiation also can cause skin damage, wound, knife injury, scald, burn, field skin wound first aid, need can defying age, antibacterial, blood circulation promoting and blood stasis dispelling, repair skin damage fast, allow the external used medicine that skin is lived again naturally.People president's acne, furuncle and phyma, acne, somebody is difficult to cure for many years, people is old, and skin can form wrinkle, has chloasma, and skin can follow the string, hair can bleach, skin keeps elasticity how to have allowed people old, wrinkle removing, whitening, speckle dispelling, anti-acne, anti-human senility, allow skin of face recover young shape and to remain youthful forever, be the target that the mankind pursue always.
The object of the present invention is to provide and a kind ofly treat dermatosis and anti-aging external used medicine.
Another object of the present invention is to provide the preparation method of this treatment dermatosis and anti-aging remedy for external use.
Solution of the present invention selects up-to-date biotechnology product rhIL-12(p70), for preventing ultraviolet, radiation penetrates and the damage of naturally-aged to the DNA of epidermis cell, by the effect of DNA repairase, repair the DNA of the skin damaged, keep the normal condition of epidermal tissue.Ultraviolet and radiation and naturally-aged all can cause the immunosuppressant of skin histology, rhIL-12(p70) has Nucleotide Sequence Analysis function, and the cyclobutane pyrimidine dimer of induction of immunity suppression can be removed, promote and maintain the immunization of skin.Simultaneously based on motherland's medical science to the sick pathogenetic understanding of skin and Therapeutic Principle, with reference to modern pharmacological research achievement, from motherland's medicine treasure-house, filter out Aloe, hydrolyzed pearl powder, Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Angelicae Sinensis, Semen Coicis, Semen Phaseoli, Lumbricus, Auricularia, Thallus Laminariae (Thallus Eckloniae), vinegar, spring water has moistening, antiphlogistic antibacterial, granulation promoting, sun-proof speckle dispelling, anti-acne, anti-ultraviolet and x-ray radiation effect, and there is blood circulation promoting and blood stasis dispelling simultaneously, promoting blood circulation, improve cardiovascular function, blood circulation promoting and enriching relaxing muscles and tendons, brighten, improve microcirculation, expansion blood capillary, suppress hematoblastic gathering, toxin expelling damp eliminating, function of nervous system is regulated to improve DNA repair ability, slow down the body resistance strengthening and constitution consolidating of the aging effect of organ-tissue, the natural edible-plant medicine of medicated diet homology.By theory of Chinese medical science prescription, skim the cream off milk.
Medicine of the present invention is made up of following component: (consumption is weight portion)
RhIL-12(p70) 5 ~ 20
Aloe liquid 0.3 ~ 15
Hydrolyzed pearl powder 0.3 ~ 15
Radix Salviae Miltiorrhizae 0.5 ~ 20
Radix Notoginseng 0.3 ~ 20
Radix Angelicae Sinensis 0.5 ~ 15
Semen Coicis 0.5 ~ 10
Semen Phaseoli 0.5 ~ 10
Lumbricus 0.5 ~ 10
Thallus Laminariae (Thallus Eckloniae) 0.5 ~ 10
Auricularia 1 ~ 15
Vinegar 5 ~ 100
Distilled water, spring water or saline 10 ~ 200
Formula preferred weight (part) ratio range preparing medicine of the present invention is:
RhIL-12(p70) 5 ~ 10
Aloe liquid 0.3 ~ 10
Hydrolyzed pearl powder 1 ~ 10
Radix Salviae Miltiorrhizae 3 ~ 20
Radix Notoginseng 1 ~ 20
Radix Angelicae Sinensis 2 ~ 15
Semen Coicis 1 ~ 5
Semen Phaseoli 1 ~ 5
Lumbricus 0.5 ~ 5
Thallus Laminariae (Thallus Eckloniae) 0.5 ~ 5
Auricularia 1 ~ 5
Vinegar 5 ~ 80
Distilled water, spring water or saline 10 ~ 100
Optimum weight (part) proportioning of external used medicine of the present invention is:
RhIL-12(p70) 10
Aloe liquid 0.3
Hydrolyzed pearl powder 1
Radix Salviae Miltiorrhizae 3
Radix Notoginseng 2
Radix Angelicae Sinensis 3
Semen Coicis 1
Semen Phaseoli 1
Lumbricus 1
Thallus Laminariae (Thallus Eckloniae) 1
Auricularia 1
Vinegar 5 ~ 50
Distilled water, spring water or saline 10 ~ 80
By the production method that above-mentioned each component makes external used medicine of the present invention be:
1, first get Folium Aloe juice to use after delead PROCESS FOR TREATMENT;
2, get Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Angelicae Sinensis, Semen Coicis, Semen Phaseoli, Lumbricus, Thallus Laminariae (Thallus Eckloniae), Auricularia, air-dry after be ground into 120 order fine powders, nanotechnology technique can be adopted.
3, by above-mentioned whole powder components in after the mixing of described ratio, add Aloe juice and hydrolyzed pearl powder carries out ripening sterilization treatment 15 ~ 35 minutes at 100 DEG C ~ 110 DEG C.
4, spring water, vinegar or saline is added in proportion according to making Emulsion, liquor, frost or unguentum demand.
5, rhIL-12(p70) biological agent should cryopreservation, puts in refrigerator, can first use separately, also can add Chinese medicinal plant and be mixed in Emulsion, liquor, frost or unguentum and facial film and use.
An important feature of the present invention is containing abundant nutrition in topical agent, wherein containing multiple proteins, natural vitamin (A, B, C, D, etc. E) 16 seed amino acids are had, leucine, methionine, alanine, glycine, glutamic acid, aspartic acid, rhIL-12(p70) is that the efficient biological activity raw material of innovation can allow skin naturally repair to live again, can prevent because of ultraviolet, radiation and naturally-aged are to the damage of the DNA of epidermis cell, by the effect to DNA repairase, repair the DNA of the skin damaged, keep the normal condition of epidermal tissue.Make skin pure white, fine and smooth, springiness.Prevent the generation of the coarse and wrinkle of skin.In addition, Thallus Laminariae (Thallus Eckloniae), aloin, anthraquinone, cinnamic acid fat have certain insulating effect to ultraviolet.
In addition, contained aloin, glycocide, enzyme resin, emodin and anthraquinone, cinnamic acid fat and mineral in treatment dermatosis of the present invention and anti-aging therapeutic agent topical agent, total tanshinones etc. are that treatment sunburn dermatitis, skin are dry, the good medicine of wound, ulcer, hair smooth pliable can be made, skin delicacy is pure white, the excellent curative of process wound and burn, scald, radiotherapy, skin damage after chemotherapy.All there is stronger killing and inhibitory action to Grain-negative, positive bacteria, have inhibition in various degree to dermatophytess such as epidermophyton inguinale, epidermophyton rubrum, star-shaped nocardias.Total tanshinone is to 8 kinds of penicillin resistants, streptomycin and chlortetracycline and the resistance to erythromycin of 50 strains, staphylococcus aureus sensitivity.TANSHINONES all has obvious antiinflammatory action to the arthroncus caused by Ovum Gallus domesticus album, chondrus ocellatus Holmes colloidality, dextran, formaldehyde and bacterium liquid inductance dye simultaneously.
Another important feature of the present invention is containing algae and earth-worm extractive as raw material, cryptotanshinone, Tanshinone I and Tanshinone I I and tens kind of monomer component and danshensu energy blood circulation promoting and blood stasis dispelling, promoting blood circulation, speckle removing in topical agent, to ex vivo thrombosis, platelet aggregation and coagulation function all have inhibitory action, danshensu can suppress myocardial ischemia, and algae has can blood circulation promoting function.There is penetration and the dissolving power of height, effect is had to the new life of cell, can opposing be oxidized, catabiosis, the contained abundant iodine of algae and water solublity mucus, thyroid can be promoted, the metabolism of hormonal secretion and cell, prevention xerosis cutis and wrinkle, the generation of black speck, pH value is weakly acidic algae, with the acid-base value of skin in energy, be rich in vitamin C to go down melanin, nutrition recuperating oiliness, dryness, sensitivity skin, and blood circulation promoting, maintain the fresh profit of skin gloss, algae has disinfective action, the dirt of sweat gland and sebaceous gland can be removed, the molecular compound of its transparence can remove the dirt in pore, make dermal respiration unimpeded.The blood vessel of ageing skin reduces relatively, and skin microcirculation weakens, and blood vessel wall is thinning, and parietal cell reduces, and reduces tissue perfusion and oxidizing process, just there will be dim complexion withered, and can not provide skin metabolism desired nutritional composition, brings out wrinkle and produces.Earth-worm extractive as raw material has and improves microcirculatory function, can the aging of effective delaying skin, and expansible blood capillary, suppresses hematoblastic gathering.The ability of fibroblastic propagation and synthesis collagen can also be promoted.Meanwhile, improve body's immunity, promote aged cells regeneration, repair damaged cell, fundamentally improve the physiological function of ageing skin.
Another important feature in addition of the present invention has adjustment function of nervous system in this topical agent.Enrich blood and invigorate blood circulation, restrain, granulation promoting, promotion tissue regeneration, strengthen the vigor of ATP enzyme, can promote that skin is delicate, promote skin health and improve DNA repair ability, and have restraint of tyrosinase active, prevent oxidizing tyrosine from forming pigment effect.Chloasma can be treated, passeris montani saturati speckle, pigmentation disease etc., function of nervous system is not normal is that a large amount of neurocyte atrophy of one of old and feeble important symbol is dead, cause old people's thinking, memory ability goes down, it is aging that kidney-nourishing and essence-enriching herb can improve old people's nervous system, reduce lipofuscin deposition and neuronic forfeiture in cerebral tissue, simultaneously, sympathetic nerve and parasympathetic activity can be made to be tending towards normal, balance and regulate the medicine of large kidney benefit essence to promote liver, kidney, DNA in spleen and Nao Deng human tissue organ, the biosynthesis of RNA and protein, improve the periphery lymphocyte DNA non-program synthesis level that old people reduces, and to DNA profiling, there is activation, obvious inhibitory action is had to the archaeal dna polymerase of external different tissue sources, thus improve DNA repair ability, slow down the aging of organ-tissue.For the life age of energy prolonged human lays the foundation, adhere to that every day smears acupuncture point with topical agent of the present invention according to the acupuncture point distribution of people, just can be anti-aging, the life age of prolonged human, dreams of that by messenger living by 150 ~ 200 years old is not impossible achieve.In addition Semen Coicis, Semen Phaseoli can strengthen the function of damp eliminating except pox, and enhancing human body immunity function, has hypoglycemic activity, is improved substance metabolism functions, and vinegar has vessel softening, effect of cholesterol reducing and beauty treatment, blood pressure lowering hair growth promoting.
Topical agent result in clinical application of the present invention shows there is following advantage:
1, the present invention selects recombinant interleukin-1 2 to repairing the skin fast efficient biological activity raw material of damage curative effect and natural edible-plant Chinese medicine is raw material, each component meets pharmaceutical control law regulation, utilize the comprehensive function of up-to-date scientific and technological biological preparation and each taste Chinese medicine anti-aging, treatment skin injury and complication thereof, act on evident in efficacy soon having no adverse reaction, harmless to human non-toxic.
2, the present invention need not oral, have an injection, only smear for human body skin, utilize nanotechnology to after natural plant Chinese processed, its composition is more directly infiltrated in skin, easy to use, safe, meet national medicine for external use health law.
3, the present invention uses comprehensive prescription application method, therapeutic effect is obviously increased, and significantly can prevent untoward reaction, reach the object for the treatment of both the principal and the secondary aspects of a disease at the same time, and living to the anti-aging dream of the mankind lays the first stone to 150 ~ 200 years old " hope ".
4, the method that topical agent of the present invention can replace expensive operation, skin is changed in surgery injection beauty treatment, and reach effect of natural beauty.
Anti-aging, whitening of the present invention changes that skin, anti-acne, speckle dispelling, wrinkle removal are antibacterial, sun-proof, the topical agent of the effect of anti-ultraviolet and radiation, to acne, furuncle and phyma, acne 3 ~ 7 days visible effective examples 10 of stubbornness, to slight comedo 2 ~ 4 days visible effective examples 15; Changing skin to whitening sees effective in 3 ~ 6 months, after 12 months, skin example 5 is changed in complete whitening, knife injury, burn, scald medicine for external use frost are coated with and can alleviate pain, recover skin epidermis effect example 10 evident in efficacy, to smearing chemotherapy after chemotherapy, radiotherapy, radiotherapy position can alleviate pain, prevent skin ulceration, repair skin and within 3 days, to take effect good effect example 20.
Within 3 ~ 6 months, see effective to chloasma, freckle, pigmentation, after 12 months, skin example 2 is changed in complete whitening, within 3 days, sees effective example 20, within 3 ~ 7 days, see effective example 5 to miliaria erythra to tinea pedis, the tinea manuum.Be coated with topical agent film energy shielding of ultraviolet before the sun-proof important affair of field work to the damage of exposure portion, prevent blackening from protecting skin-whitening example 2.Clinical verification just needing to anti-aging extending life age.
Embodiment
Raw material is taken by following proportioning:
RhIL-12(p70) 10 μ g
Aloe liquid 0.3g
Hydrolyzed pearl powder 1g
Radix Salviae Miltiorrhizae 3g
Radix Notoginseng 2g
Radix Angelicae Sinensis 3g
Semen Coicis 1g
Semen Phaseoli 1g
Lumbricus 1g
Thallus Laminariae (Thallus Eckloniae) 1g
Auricularia 1g
Vinegar 5 ~ 20ml
Distilled water, spring water or saline 10 ~ 50ml
Production method is as follows:
First get Aloe juice to use after delead PROCESS FOR TREATMENT; Get Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Angelicae Sinensis, Semen Coicis, Semen Phaseoli, Lumbricus, Thallus Laminariae (Thallus Eckloniae), Auricularia air-dry after be ground into 120 order fine powders, nanotechnology technique can be adopted.By above-mentioned whole powder components in after described ratio mixing, add Aloe juice and hydrolyzed pearl powder carries out ripening sterilization treatment 15 ~ 35 minutes at 100 DEG C ~ 110 DEG C, according to making Emulsion, liquor, frost or unguentum demand, add spring water, vinegar or saline in proportion.The suitable cryopreservation of rhIL-12(p70) biological preparation, put in refrigerator, re-use natural plant Chinese liquor after can first smearing skin during use and smear same position, also can add in natural plant Chinese agent to be mixed in Emulsion, liquor, frost or unguentum and facial film and use, product also should be placed in refrigerator.
Claims (5)
1. treat dermatosis and an anti-aging external used medicine, it is characterized in that it is liquor, cream, unguentum or the facial film be made up of the raw material of following weight proportioning:
2. treatment dermatosis according to claim 1 and anti-aging external used medicine, wherein the weight proportion of each raw material is:
3. treatment dermatosis according to claim 1 and anti-aging external used medicine, wherein the weight proportion of each raw material is:
4. the preparation method for the treatment of dermatosis according to claim 3 and anti-aging external used medicine, after it is characterized in that first getting aloe liquid delead PROCESS FOR TREATMENT, by Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Angelicae Sinensis, Semen Coicis, Semen Phaseoli, Lumbricus, Thallus Laminariae (Thallus Eckloniae), Auricularia drying and crushing to 120 order fine powder, above-mentioned whole powder is added aloe liquid and hydrolyzed pearl powder in after described ratio mixing, ripening sterilization treatment 15 ~ 35 minutes obtained powder is carried out at 100 DEG C ~ 110 DEG C temperature, then with vinegar, distilled water, spring water or saline and rhIL-12(p70) are made into liquor, cream, unguentum or facial film.
5. the preparation method for the treatment of dermatosis according to claim 4 and anti-aging external used medicine, ripening disinfecting action wherein adopts staged cooling ripening sterilizing, temperature is raised to rapidly 110 DEG C, and then segmentation drops to 100 DEG C, and ripening sterilization time is 15 ~ 35 minutes.
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| CN102525866B (en) * | 2012-01-11 | 2013-07-10 | 山东大学威海分校 | Cosmetic additive, and preparation method and application thereof |
| CN103120729A (en) * | 2013-02-28 | 2013-05-29 | 江苏丹晟生物科技有限公司 | Traditional Chinese medicine composition for treating whelk and acne rosacea, and preparation method of total tanshinones |
| CN105920119A (en) * | 2016-04-29 | 2016-09-07 | 丽水市人民医院 | Traditional She medicine for treating skin injury and application method thereof |
| CN106727115B (en) * | 2016-12-13 | 2019-08-13 | 广东科玮生物技术股份有限公司 | A kind of face cream and preparation method thereof for hyperplastic scar reparation |
| CN107375906B (en) * | 2017-07-28 | 2018-06-08 | 广东科玮生物技术股份有限公司 | A kind of scar repair agent and preparation method thereof |
| CN108079276A (en) * | 2017-12-07 | 2018-05-29 | 常州市天宁区鑫发织造有限公司 | A kind of preparation method for scar topical agent of dispelling |
| CN109010802A (en) * | 2018-09-21 | 2018-12-18 | 珠海汉盈科技有限公司 | The spontaneous hotting mask of promotion burn wound reparation containing Salvia root P.E |
| CN109157652A (en) * | 2018-09-21 | 2019-01-08 | 珠海汉盈科技有限公司 | The spontaneous hotting mask of promotion burn wound reparation containing Radix Arnebiae extract |
| CN108969508A (en) * | 2018-09-21 | 2018-12-11 | 珠海汉盈科技有限公司 | The spontaneous hotting mask of promotion burn wound reparation containing aloe extract |
| CN113476586B (en) * | 2021-07-08 | 2024-05-10 | 神究富硒农业发展(山东)有限公司 | Preparation method of selenium-enriched cell repair liquid |
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| CN1506108A (en) * | 2002-12-09 | 2004-06-23 | 戚海燕 | Composite milk powder capable of being eaten and made into beautifying face mask |
| CN1568934A (en) * | 2004-05-08 | 2005-01-26 | 范春龙 | Long-acting facial tissue treated by Chinese traditional medicine and production method thereof |
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Effective date of registration: 20161025 Address after: 510730 Guangzhou Province, free trade zone, Guangdong Avenue, No. 301, room 39 Patentee after: Guangdong Kewei Biological Technology Co., Ltd. Address before: 511442 Guangdong Province, Guangzhou City Southern towns Panyu District Southern China Biguiyuan Chui Street No. 8 Yuanyi Patentee before: Zhang Zhiqun |