CN106420963A - Medicinal and edible active rooting preparation (tablet) and preparation method thereof - Google Patents
Medicinal and edible active rooting preparation (tablet) and preparation method thereof Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 29
- 239000003814 drug Substances 0.000 claims abstract description 25
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 10
- 230000001076 estrogenic effect Effects 0.000 claims abstract description 7
- 208000011580 syndromic disease Diseases 0.000 claims abstract description 7
- 239000008187 granular material Substances 0.000 claims abstract description 6
- 238000013329 compounding Methods 0.000 claims abstract description 5
- 239000004577 thatch Substances 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 239000012567 medical material Substances 0.000 claims description 4
- 239000000314 lubricant Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 238000007598 dipping method Methods 0.000 claims description 2
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- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
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- 229960005309 estradiol Drugs 0.000 description 1
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- 239000000469 ethanolic extract Substances 0.000 description 1
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- 235000006539 genistein Nutrition 0.000 description 1
- 229940045109 genistein Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/65—Amphibians, e.g. toads, frogs, salamanders or newts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
- A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an active rooting preparation (tablet) which has estrogenic effects according to experimental evidence and is formed by compounding medicinal and edible traditional Chinese medicine rhizoma cimicifugae with kudzuvine roots, and aims to provide a novel safe effective natural preparation for clinically treating climacteric syndrome only by harmful chemical female hormone at present. The active rooting preparation (tablet) is beneficial to rejuvenation and anti-aging of middle and aged people, and can also enhance young blood and physical agility of men and women above 30 years old. The active rooting preparation (tablet) is mainly characterized by components and a preparation method of the preparation, effective components of various traditional Chinese medicines are extracted by an alcohol extraction method and prepared into thick paste, the thick paste is machined into granules, the granules are dried, pelletized and pressed, quality is inspected, and qualified products are packaged.
Description
Technical field
Vigor rises root preparation (piece) and preparation method thereof, for preventing and treating climacteric syndrome, promoting middle-aging male and women
Youthful vigor and physical ability, a kind of novel natural agent of suitable for men women and children, safe and reliable integration of edible and medicinal herbs is provided.Belong to medicine bioengineering
Learn technical field.
Technical background
With aged tendency of population and generally long-lived, all one's life of people there are about more than 1/3 and tides over climacteric.Wherein women
More than 50% in menopause and later can symptom because of the continuous decline of estrogen level, and has in years and enter in advance
Involutional trend.China's climacteric（45 ~ 65 years old）More than 1.2 hundred million, this is of current climacteric care to female population
The field that must pay attention to.
The youthful vigor of women maintains by estrogen.The tissue at more than 400 position and organ is had to be subject to estrogen in women body
Effect and keep its function.When involutional arrival, because of decline, these tissues and the device of the decline of ovarian function, estrogen
Just there are a series of changes in official.If occurring in nervous system, anxious state of mind, movability, anxiety, depression, insomnia will occur
Deng；If occurring in cardiovascular system it may appear that hectic fever, cardiopalmus, blood pressure raise shakiness etc.；If occurring in genitourinary system,
Disorder of menstrual cycle, vaginal dryness, atrophy occur or urinary tract infection, hyposexuality etc. occur；If occurring in skin skeletal system, skin
Relax shrivelled, hair of skin is dilute thin, osteoporosises etc..Middle-aged men and old men as the change of endocrinal environment and under generation vigor
Fall, unable to do what one wishes, anxiety, absent minded, hyposexuality, cardiovascular and cerebrovascular disease are multiple etc..
In order to treat climacteric syndrome, Clinical practice controversies in hormone replacement in the elderly, there is good therapeutic effect, but solid with this species
Alcohol estrogen does not only have side effect and contraindication, and has induction breast carcinoma, the danger of carcinoma of endometrium.Therefore, from natural
In Chinese medicine find safety also have estrogen action natural medicine substitute synthetic, have broad application prospects and
Economic results in society.
Lack that a kind of person in middle and old age are unisex can be prevented and can treat female climacteric syndrome in the market
The safe and reliable natural medicine of middle-aging male youthful vigor can be promoted（Natural medicine, natural health-care products）.
Content of the invention
We have selected one group of Chinese medicine with estrogen -like effectss with testing sieve, here it is vigor rises root preparation（Piece）In
Fiery cylinder bar, Radix Puerariae, thatch three taste composition compounding Chinese medicine.Experiment is using weanling children Mus（NIH strain）.In compounding for this group
The alcohol extract of medicine, applies skin administration, each 0.15ml to young Mus, twice daily, checks young Mus vaginal exfoliated after continuous 6 days.
Result shows：There are 8 vaginas that keratinocyte homogeneous in a large number occurs in the young Mus of Chinese medicine group 9, with 4 young Mus phases of estradiol group
With.Show that Chinese medicine group and the young Mus of estradiol group all enter rutting period in advance.But the young Mus vagina of matched group 7 to normal saline
It is showed no keratinocyte.Meanwhile, the average weight in young Mus uterus, from 8.47 ± 1.96ml of saline control group, increases
19.66 ± 2.28mg (p to Chinese medicine group<0.05), thus proving that Chinese medicine group has clear and definite estrogen -like effectss.In addition, skin
What 8 of medicine ethanol extract young Mus and matched group were hit in bet has more also obtained equifinality.
Contained active component in these Chinese crude drugs of fiery cylinder bar, Radix Puerariae, thatch, such as triterpene glycoside, daidzein, thorn awns handle
Florigen, genistein etc., though these compositions are not estrogen has estrogen -like effectss, also have two-ways regulation and make
With.Lisk E research manufactures experimently 629 climacteric syndrome patients with fiery cylinder bar alcohol extraction liquid formulation, serve on 80% patient after surrounding
Symptom is obviously improved, and after 6 ~ 8 weeks, the symptom of most of patient is wholly absent.Thatch, is abroad to be used for adjusting men and women's sexual dysfunction
A kind of edible medical herbs.The research such as Milanov thatch preparation uses to 8 male 8 dresses（3 times/day × 5 days）, record in 8 male
Serum testosterone and lutropin increase, and follicle stimulating hormone（FSH）Unchanged；Estradiol and FSH liter is recorded in 8 women
Height, and testosterone is unchanged.And after taking 30 ~ 60 days to 212 male sterilities and cacospermia, sexual dysfunction person, send out
Now hyposexuality, patient few smart and that sperm motility is bad are had by good therapeutical effect, and have no adverse reaction.
It is to tests prove that the Chinese medicine with estrogen -like effectss by above-mentioned three tastes that vigor rises root preparation, then is aided with Chinese forest frog institute
Composition.Chinese forest frog, i.e. Rana temporaria chensinensis David, Oviductus Ranae, for Chinese distinctive rare Chinese medicine, have yin nourishing nourishing kidney function.Chinese forest frog is rich in people
The biogenic various nutrient substance of body, contribute to improving body constitution, strengthen physical ability.It is required that these full nutrient substance include
Fatty acid（ω-3）, essential amino acids, essential trace element and vitamin, and nucleic acid, phospholipid etc..According to Ward. Pierre Bao Li
Doctor's research finds, takes ω -3（DHA、EPA）Aged Mus, its sexual behaviour enlivens once again, and its life-span also extends.Modern medicine
Research has shown that ω -3 contributes to protecting cardiovascular and cerebrovascular vessel, lipid-loweringing, blood pressure lowering, improves the function of nerve immunity system, also can improve climacteric
Phase various discomfort.In addition, Chinese forest frog also be rich in arginine, it in vivo nitric oxide (NO) synthesis enzyme effect under, NO can be generated, this
Also coronary artery dilating and spongy body blood vessel are contributed to.
Health person answers " preventive treatment of disease ".Fiery cylinder bar, Radix Puerariae etc. also have concurrently and improve cardiovascular and cerebrovascular vessel, reduce myocardial oxygen consumption, suppression
Platelet aggregation, lipid-loweringing, blood sugar lowering, blood pressure lowering, improve person in middle and old age's osteoporosises, prevention prostatosis, antiinflammatory, antioxidation, calmness
Deng effect.These each contribute to the health that " preventive treatment of disease " protects person in middle and old age.
Vigor rises root preparation（Piece）Recipe ingredient and weight proportion as follows：
Fiery cylinder bar 8 ~ 60% Radix Puerariae, 10 ~ 70% thatch 8 ~ 55% Chinese forest frog 8 ~ 60%.
Vigor rises root preparation（Piece）Preparation method as follows：
Thick paste processed：
By formulation weight proportioning weigh above-mentioned purified drying Chinese crude drug coarse pulverization it；Plus six times amount 70% alcohol dipping is overnight
Post-heating flows back, leaching extracting solution.It is repeated once, merge filtrate twice；Reclaim ethanol, be concentrated into paste（Four grams of medical materials/gram
Thick paste）
Granulation, granulate：
Take thick paste, plus appropriate excipient, wetting agent, mix it, make soft material；Enter granulator extruding, be allowed to into wet granular；Decompression
It is dried, sieve granulate, obtains final product dry particle
Tabletting：
Take dry particl, plus lubricant and disintegrating agent, mix；Use tabletting machine（0.5 gram/piece）, sugar coating, quality examination is closed
Lattice, subpackage.
Embodiment：
Vigor rises root preparation（Piece）Preparation, taking 10000 as a example
Take the vigor that extraction is made to rise 5000 grams of root preparation dry particl plus lubricant, disintegrating agent → mixing → tabletting → coating, throw
Light → quality examination → subpackage.
Vigor rises root preparation（Piece）Being mainly used in the multiple organ that causes because of decrease in estrogen organizing systemic-function more
The treatment for diseases of sexual maladjustment, is particularly well-suited to the preventing and treating of person in middle and old age and climacteric syndrome；In view of vigor rises the one of heel piece prescription
A little Chinese medicines with protection cardiovascular and cerebrovascular vessel, strengthen the multiple efficacies such as skeleton, looks improving and the skin nourishing, and be the Chinese medicine of integration of edible and medicinal herbs, peace
Good perfection, is therefore available for more than 30 years old subhealth state person's " preventive treatment of disease ", to improve body constitution, strengthen physical ability, keep body youthful vigor
Anti-ageing with rejuvenating.Rising heel piece is not chemical " viagra ", but whether gentle and kindhearted women viagra sample effect Worth Expecting.
Claims (3)
1. a kind of vigor rises root preparation（Piece）And preparation method thereof, one of its technical characteristic is that the selection of science the experiment proved that
There is the compounding Chinese medicine of estrogen -like effectss, its formula and weight proportion are as follows：Fiery cylinder bar 8 ~ 60% Radix Puerariae 10 ~ 70% thatch
8 ~ 55% Chinese forest frog 8 ~ 60%.
2. vigor described in claim 1 rises root preparation（Piece）And preparation method thereof, the two of its technical characteristic is to be carried with alcohol extracting method
Take its effective ingredient, then make tablet by modern Chinese medicine preparation process：Thick paste processed：Weigh Chinese medicine by formula, after coarse pulverization,
Plus 70% ethanol, dipping post-heating backflow；Leaching while hot, merges filtrate twice；It is concentrated into paste（Four grams of medical material/gram thick pastes）；
Granulation, granulate：Thick paste is taken to make soft material after mixing with excipient, wetting agent, wet grain made by machine；Drying under reduced pressure；Sieve granulate, obtains
Dry granular；Tabletting：Take dry granular, plus tabletting after the mixing of lubricant, disintegrating agent（0.5 gram/piece）, sugar coating, through quality inspection, qualified after
Packaging.
3. vigor rises root preparation（Piece）And preparation method thereof technical characteristic three be natural product, compounding medical material be medicine food
The food medical material of homology, you can work as medicine, also can work as health food and eat, safety is good, have estrogen -like effectss it is adaptable to more
The accurate prevention and control of term syndrome；Also contribute to adjust and strengthen youthful vigor and the physical ability of more than 30 years old men and women, suitable for men women and children；
Minor is unsuitable.
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| CN201610851043.XA CN106420963A (en) | 2016-09-27 | 2016-09-27 | Medicinal and edible active rooting preparation (tablet) and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101036722A (en) * | 2006-03-15 | 2007-09-19 | 张丽英 | Health-caring food for easing and improving climacteric Syndrome of men and the preparation thereof |
| CN102038927A (en) * | 2009-10-10 | 2011-05-04 | 王新祥 | Pharmaceutical composition for preventing and treating climacteric metancholia and other diseases |
| CN102872425A (en) * | 2012-10-26 | 2013-01-16 | 谢春红 | Chinese medicinal decoction for treating climacteric syndrome |
-
2016
- 2016-09-27 CN CN201610851043.XA patent/CN106420963A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101036722A (en) * | 2006-03-15 | 2007-09-19 | 张丽英 | Health-caring food for easing and improving climacteric Syndrome of men and the preparation thereof |
| CN102038927A (en) * | 2009-10-10 | 2011-05-04 | 王新祥 | Pharmaceutical composition for preventing and treating climacteric metancholia and other diseases |
| CN102872425A (en) * | 2012-10-26 | 2013-01-16 | 谢春红 | Chinese medicinal decoction for treating climacteric syndrome |
Non-Patent Citations (1)
| Title |
|---|
| 吴海锋: ""膏方医案"", 《吴氏膏方验案》 * |
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