CN102000135A - Jingtianling traditional Chinese medicine preparation and preparation method - Google Patents
Jingtianling traditional Chinese medicine preparation and preparation method Download PDFInfo
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Abstract
The invention discloses a Jingtianling traditional Chinese medicine preparation, which is compounded by rhodiola, acanthopanax, Ganoderma lucidum and a proper amount of excipients. The preparation is prepared by the following prescriptions: 750g rhodiola, 450g acanthopanax, 750g Ganoderma lucidum and a proper amount of excipients. A preparation method comprises steps of: taking the rhodiola and the acanthopanax, adding 75% ethanol, heating and refluxing the mixture twice, combining extracts, recovering and concentrating the ethanol to a proper amount for spare use; adding water after adding medicine dregs to the Ganoderma lucidum and decocting the mixture twice, combining, decocting and concentrating the mixture, combining and concentrating two concentrated solutions into an extract, drying and crushing the extract into fine powders, adding starch and magnesium stearate to the powders, pressing the mixture into tablets or preparing into capsules and soft capsules, or preparing into granules and oral liquids. The traditional Chinese medicine preparation which is a health-care food is effective, safe, reliable, advanced in preparation process, stable in formulation, controllable in quality, convenient to take, specifically used for treating CFS and strengthening immunity. The preparation can bring benefits to growing numbers of chronic fatigue syndrome (CFS) patients.
Description
Technical field
The present invention relates to Chinese medicine, particularly relate to a kind of treatment chronic fatigue syndrome (CFS) and enhancing immunity Herba hylotelephii erythrosticti spirit Chinese medicine preparation and preparation method for health care.
Background technology
Chronic fatigue syndrome (CFS) is a kind of disease that modern medicine is confirmed recently.Over surplus in the of ten year, American-European countries reported one group of etiology unknown successively, clinically with chronic or outbreak repeatedly extremely tired and to continue to more than not a half year be the syndrome of feature.Is chronic fatigue syndrome from the Center for Disease Control in 1988 with this syndrome definite designation, and has drafted after the CFS diagnostic criteria, and the report of relevant case has appearred in world many countries successively, to the also expansion in succession of research of CFS.Find according to U.S.'s Epidemiological study, 14% adult male among the crowd, 29% women performance has tangible fatigue symptom, and number reaches 3,000,000-4,000,000.Wherein 40% above patient's cisco unity malfunction and study.The Center for Disease Control prediction, confirmed fatigue will become 21 century influences one of subject matter of human health.
Domestic research to CFS shows slightly hysteresis, does not see the report of it being carried out Epidemiological study so far.Relevant report has been summarized external research situation.Current, domestic academia has recognized that a undisputable fact, promptly along with the continuous quickening of people work and rhythm of life, and the enhancing day by day of competing and striving and realize, confirmed fatigue is growing on and on as a kind of common sympton or with the prescription on individual diagnosis person that fatigue is chief complaint, and is just encroaching on patient's physical and mental health.
Because CFS is year preceding name surplus in the of ten, so corresponding with it disease still unconfirmed in the Chinese medicine.But the CFS cardinal symptom is all existing relevant empirical record of discussing and treat in Chinese medicine.
About fatigue, often be expressed as in Gu doctor nationality that asthenia, slack, slack lazy, limbs asthenia, extremity asthenia, extremity overstrain, extremity are weak and limp, flaccidity of the limbs, inability to raise the limbs, myasthenia of limbs, weak, unable, empty weary, extremity are heavy, heavy sensation of the body etc." element is asked. declare five gas pieces of writing " can think relevant tired early stage understanding about the record of " five kinds of over strain ".
The tired cause of disease and pathogenesis, motherland's medical science also early have understanding, " element is asked. show calm opinion " and think: " flaccidity of the limbs, this inability of the spleen to transport the essence of food are also "; " Shengji Zonglu. the asthenia door " cloud: " impairment caused by overstrain very, the tired utmost point of health "; " eastern wall ten books. inability to bend the limbs " claim: " taste void is tiredness with somnolence then, inability to bend the limbs "; " Treatise on the spleen and stomach. taste win the opinion that declines " point out: " the body forced labour is the splenopathy then, and sick spleen is tiredness with somnolence then, inability to bend the limbs, loose stool and diarrhea.Spleen was both sick, and its stomach body fluid of can not walking alone then is so thereby also disease is here ": in addition, " element is asked. six save state of internal organs opinions " saying of " liver person, source of endurance " then arranged; " Medical Treasures of the Golden Chamber " thought: asthenia is given birth to, because of " rank and honour is gone into the weak bone skin and contained, and is heavy because of tired sweating, shaking frequently when lying in bed, add by mild wind satisfy it ".Make a general survey of ancient medicine institute opinion, tired sick position is at the spleen regulating liver-QI, this and traditional Chinese medical science what is called spleen governing muscles and extremity, and understanding such as liver governing tendons match.To the understanding of CFS, diagnosis and treatment are put in face of Chinese medicine and pharmacy realistically.
Summary of the invention
The technical problem to be solved in the present invention, be to lack efficient ways in view of understanding, diagnosis and treatment to CFS, develop the Chinese medicine characteristic, answer patient's need, develop a kind of determined curative effect, dosage form is stable, safe and reliable, preparation is advanced, taking convenience, special for treating CFS and enhancing immunity Herba hylotelephii erythrosticti for health care spirit Chinese medicine preparation and preparation method.
The technical scheme that adopts is:
Herba hylotelephii erythrosticti spirit Chinese medicine preparation, formulated by Radix Rhodiolae, Radix Et Caulis Acanthopanacis Senticosi, Ganoderma and appropriate amount of auxiliary materials.Its prescription is: the big 750g of red scape, Radix Et Caulis Acanthopanacis Senticosi 750g, Ganoderma 750g, right amount of auxiliary materials.
The preparation method of Herba hylotelephii erythrosticti spirit Chinese medicine preparation:
A, Herba hylotelephii erythrosticti spirit sheet
Get Radix Rhodiolae 750g, Radix Et Caulis Acanthopanacis Senticosi 750g, adding 75% alcohol heating reflux extracts twice, its reflux, extract, heating and temperature control is at 80-90 ℃, steam pressure is 1-1.5Mpa, add for the first time 5 times of amount 75% alcohol heating reflux 2 hours, add 4 times of amount 75% alcohol heating reflux 1.5 hours for the second time, merge extractive liquid,, reclaim ethanol and be concentrated into an amount of, standby; Medicinal residues add Ganoderma 750g, decoct with water twice, and it decocts temperature and is controlled at 100 ℃, and steam pressure is 1-1.5Mpa, add 10 times of water gagings for the first time and decoct 3 hours, add 8 times of water gagings for the second time and decoct 2 hours, and collecting decoction filters.Be evaporated in right amount, two concentrated solutions merging are concentrated into the clear paste that relative density is 1.10-1.30 (80 ℃ of survey), drying is ground into fine powder, and add appropriate amount of starch and make granule, drying, the adding magnesium stearate is an amount of, mixing, compacting is in blocks.
B, Herba hylotelephii erythrosticti spirit granule (containing sucrose)
Get Radix Rhodiolae 750g, Radix Et Caulis Acanthopanacis Senticosi 750g, adding 75% alcohol heating reflux extracts twice, its reflux, extract, heating and temperature control is at 80-90 ℃, steam pressure is 1-1.5Mpa, add for the first time 5 times of amount 75% alcohol heating reflux 2 hours, add 4 times of amount 75% alcohol heating reflux 1.5 hours for the second time, merge extractive liquid,, reclaim ethanol and be concentrated into an amount of, standby; Medicinal residues add Ganoderma 750g, decoct with water twice, and it decocts temperature and is controlled at 100 ℃, steam pressure is 1-1.5Mpa, adds 10 times of water gagings for the first time and decocts 3 hours, adds 8 times of water gagings for the second time and decocts 2 hours, collecting decoction, filter, be evaporated in right amount, two concentrated solutions merging are concentrated into the clear paste that relative density is 1.10-1.30 (80 ℃ of survey), 1 part and 4 portions sucrose of qinghuo reagent, mixing is made granule, drying.
C, Herba hylotelephii erythrosticti spirit granule (no sucrose)
Get Radix Rhodiolae 750g, Radix Et Caulis Acanthopanacis Senticosi 750g, adding 75% alcohol heating reflux extracts twice, its reflux, extract, heating and temperature control is at 80-90 ℃, steam pressure is 1-1.5Mpa, add for the first time 5 times of amount 75% alcohol heating reflux 2 hours, add 4 times of amount 75% alcohol heating reflux 1.5 hours for the second time, merge extractive liquid,, reclaim ethanol and be concentrated into an amount of, standby; Medicinal residues add Ganoderma 750g, decoct with water twice, and it decocts temperature and is controlled at 100 ℃, steam pressure is 1-1.5Mpa, adds 10 times of water gagings for the first time and decocts 3 hours, adds 8 times of water gagings for the second time and decocts 2 hours, collecting decoction filters, and is evaporated to an amount of, two concentrated solutions merging are concentrated into the clear paste that relative density is 1.10-1.30 (80 ℃ of survey), and drying is ground into fine powder, add dextrin 730g, steviosin 1g mixing is used the 20-30% alcohol granulation, drying.
D, Herba hylotelephii erythrosticti curing capsule
Get Radix Rhodiolae 750g, Radix Et Caulis Acanthopanacis Senticosi 750g, adding 75% alcohol heating reflux extracts twice, its reflux, extract, heating and temperature control is at 80-90 ℃, steam pressure is 1-1.5Mpa, add for the first time 5 times of amount 75% alcohol heating reflux 2 hours, add 4 times of amount 75% alcohol heating reflux 1.5 hours for the second time, merge extractive liquid,, reclaim ethanol and be concentrated into an amount of, standby; Medicinal residues add Ganoderma 750g, decoct with water twice, and it decocts temperature and is controlled at 100 ℃, and steam pressure is 1-1.5Mpa, add 10 times of water gagings for the first time and decoct 3 hours, add 8 times of water gagings for the second time and decoct 2 hours, and collecting decoction filters.Be evaporated in right amount, two concentrated solutions merging are concentrated into the clear paste that relative density is 1.10-1.30 (80 ℃ of survey), drying is ground into fine powder, adds magnesium stearate 2.3g, and mixing incapsulates.
E, Herba hylotelephii erythrosticti spirit soft capsule
Get Radix Rhodiolae 750g, Radix Et Caulis Acanthopanacis Senticosi 750g, Ganoderma 750g, Cera Flava 3.33g, vitamin E 0.27g, soybean oil 168g, Radix Rhodiolae 750g, Radix Et Caulis Acanthopanacis Senticosi 750g are added 75% acetic acid hot reflux to be extracted twice, its reflux, extract, heating and temperature control is at 80-90 ℃, steam pressure is 1-1.5Mpa, add for the first time 5 times of amount 75% alcohol heating reflux 2 hours, add 4 times of amount 75% alcohol heating reflux 1.5 hours for the second time, merge extractive liquid,, reclaim ethanol and be concentrated into an amount of, standby; Medicinal residues add Ganoderma 750g, decoct with water twice, and it decocts temperature and is controlled at 100 ℃, and steam pressure is 1-1.5Mpa, add 10 times of water gagings for the first time and decoct 3 hours, add 8 times of water gagings for the second time and decoct 2 hours, and collecting decoction filters.Be evaporated in right amount, add ethanol and make that to contain the alcohol amount be 78%, leave standstill more than 12 hours, being evaporated to relative density is the clear paste of 1.10-1.30 (80 ℃ of surveys), spray drying.Superfine powder is broken into fine powder, gets Herba hylotelephii erythrosticti spirit extract; Extract adds soybean oil 168g, vitamin E 0.27g, Cera Flava 3.33g, grinds evenly with colloid mill, makes capsule-core, and the softgel shell that is mixed with gelatin, glycerol, water, red ferric oxide is pressed into soft capsule.
G, Herba hylotelephii erythrosticti spirit mixture (oral liquid)
Get Radix Rhodiolae 750g, Radix Et Caulis Acanthopanacis Senticosi 750g, adding 75% alcohol heating reflux extracts twice, its reflux, extract, heating and temperature control is at 80-90 ℃, steam pressure is 1-1.5Mpa, add for the first time 5 times of amount 75% alcohol heating reflux 2 hours, add 4 times of amount 75% alcohol heating reflux 1.5 hours for the second time, merge extractive liquid,, reclaim ethanol and be concentrated into an amount of, standby; Medicinal residues add Ganoderma 750g, decoct with water twice, and it decocts temperature and is controlled at 100 ℃, and steam pressure is 1-1.5Mpa, add 10 times of water gagings for the first time and decoct 3 hours, add 8 times of water gagings for the second time and decoct 2 hours, and collecting decoction filters.Be evaporated to an amount of, it is the clear paste of 1.10-1.30 (80 ℃ of surveys) that two concentrated solutions are merged filtering and concentrating to relative densities, puts coldly, adds ethanol and makes that to contain the alcohol amount be 70% to stir evenly, leave standstill more than 12 hours, filter, filtrate recycling ethanol is not to there being the alcohol flavor, add stupid sodium formate, sucrose dissolved after, adding distil water, stir evenly, left standstill 12 hours, filter.
The side separates
Radix Rhodiolae has strengthening the body resistance, benefiting QI and nourishing blood, brain tonic and intelligence development functions.With its strengthening the body resistance, benefiting QI and nourishing blood, stress invigorating the spleen and replenishing QI, be the pathogenesis that hits, be monarch drug in the side so stand.Hold concurrently with nourishing the brain and improving intelligence, regulate the mark of symptom.
The hot little hardship of Radix Et Caulis Acanthopanacis Senticosi and warm in nature is " analeptic " (" northeast medicinal plants will ") that merit is apt to replenishing QI to invigorate the spleen, " cure mainly the neurasthenia, the deficiency of vital energy is weak " diseases such as (" Changbai Mountain plant amedica will ").
The Ganoderma sweet in the mouth is flat, is longer than replenishing QI and blood, tranquilizing mind, strengthening the spleen and stomach.The enantiomorph weakness, insufficiency of vital energy and blood and various visceral dysfunction disease all have strengthening by means of tonics and regulating action." this Bi warp " claims its " beneficial motive, invigorating middle warmer increases wisdom; do not forget ", " Newly Revised Canon of Materia Medica " with its " tranquilizing mind ", Compendium of Material Medica then has the usefulness of " treatment asthenia ", and " Chinese medicinal plants illustrated handbook " claims its " chronic diseases such as pool neurasthenia, insomnia, dyspepsia ".Two medicine mutual reinforcements between are usefulness, help the Radix Rhodiolae invigorating the spleen and replenishing QI altogether, ministerial drug in the side of being combined into.In a word, this agent property of medicine is gentle, stresses with mending, and closes and is usefulness, plays invigorating the spleen and replenishing QI altogether. relieving fatigue, the merit of the Fructus Alpiniae Oxyphyllae of calming the nerves.
This product is with Radix Rhodiolae, and Radix Et Caulis Acanthopanacis Senticosi and Ganoderma extract are primary raw material, makes with suitable processes, through the evidence of animal function assessment, has the health care for the treatment of chronic effort syndrome and enhancing immunity.
Raw material and use foundation
Radix Rhodiolae: be dry root and the rhizome of the big Rhodiola cenulata of the big premium scape of Crassulaceae plant (Hook.f.et Thomas) II.ohba.The cultivation product main place of production: Jilin Province near a river, ground such as Tonghua, Yanji, Fusong, Huijiang, the main place of production, Liaoning Province for radically reform, new county such as guest.Relevant studies show that, the root of Rhodiola sachalinensis tincture has strong effect, and anti-syngignoscism is arranged winter, and syngignoscism is then arranged spring.Can be observed excitation behind the injection rhodosin 0.1ml/20g.Mice pole-jump test and heavy burden pole-jump test, rhodiola rosea formulated product all can significantly increase the persistent period, increase work efficiency.Rhodiola rosea formulated product can make the life span of mice in the sealed container prolong one times.Rhodiola rosea formulated product can improve the muscle power of trial volunteer and intelligence, ability to work index, and the error of performance rate is reduced, and improves literal proof-reading amount, vitality and efficient, shortens heart rate, makes blood pressure recover normal.Healthy people takes one course of treatment of rhodiola rosea formulated product, can improve the intensity of attention, memory and process of excitation.For the neurosis patient, take the excitement and the process of inhibition that can strengthen the patient after a course of treatment, it is normal that motility recovers.
Ganoderma: this product is the dry sporophore of Polyporaceae fungus Ganoderma lucidum (Leyss. Ex Fr.) Karst. or Ganoderma.Gather the whole year, removes impurity, wipes out the lower end stem with rotten wood, silt or culture matrix, dries in the shade or 40-50 ℃ of oven dry.
See the earliest and be stated from " book on Chinese herbal medicine warp ", promptly claim its " beneficial motive; invigorating middle warmer; increase wisdom; do not forget " in the book, " Newly Revised Canon of Materia Medica " cloud its " tranquilizing mind ", Compendium of Material Medica are then used its " treatment asthenia ", and " Chinese medicinal plants illustrated handbook " claims its " training the mind is through chronic diseases such as weak, insomnia, dyspepsias ".Pharmacodynamic study shows that ganoderol extract lumbar injection can obviously strengthen the central inhibitory action of pentobarbital sodium; Ganoderma lucidum (Leyss. Ex Fr.) Karst. hot water extractum also gavages can obviously reduce spontaneous activity in mice, and can significantly strengthen the sedation of pentobarbital sodium; Isolating proteoglycan lumbar injection can make cell, macrophage, polymorphonuclear leukocyte in the mouse peritoneal transudate increase in the Ganoderma lucidum (Leyss. Ex Fr.) Karst., show the immune strengthening effect is arranged: the Ganoderma lucidum (Leyss. Ex Fr.) Karst. hot water extract can obviously resist hydrocortisone and ciclosporin A in vitro and suppress mouse spleen generation interleukin, 2 (1L-2), promote the generation of IL-2, holistic approach proves that also Ganoderma lucidum (Leyss. Ex Fr.) Karst. can promote splenocyte to produce IL-2, even use at the same time under the condition of immunosuppressant, the generation of IL-2 still significantly increases.
Radix Et Caulis Acanthopanacis Senticosi: be the root and rhizome or the stem of Araliaceae Radix Et Caulis Acanthopanacis Senticosi.Spring and autumn is gathered, cleaning, drying.
Radix Et Caulis Acanthopanacis Senticosi is " analeptic " (" northeast medicinal plants will "), can diseases (" Changbai Mountain plant amedica will ") such as " the QI invigorating benefit are smart, cures mainly the neurasthenia, and the deficiency of vital energy is weak ".Pharmacodynamic study shows that the Radix Et Caulis Acanthopanacis Senticosi water extract is injected to mouse peritoneal, and sedation is arranged, and reduces soluble hexobarbital and sleeps incubation period, prolongs its length of one's sleep, and the successive administration sedation is stronger; Gavage Radix Et Caulis Acanthopanacis Senticosi alcohol extraction aqueous solution every day for mice or Cavia porcellus, can obviously increase monokaryon-phagocyte and peritoneal macrophage phagocytic activity, irritate the stomach Radix Et Caulis Acanthopanacis Senticosi extract every day for mice, obviously stop because of T, bone-marrow-derived lymphocyte, killer cell due to the fatigue of swimming, non-specific immunity descends, Radix Et Caulis Acanthopanacis Senticosi polysaccharide obviously increases the antibody secreting cell of mice IgG secretion, IgM, and prompting strengthens the specific humoral immunity function, and Radix Et Caulis Acanthopanacis Senticosi polysaccharide can significantly improve the ability that cell produces interferon.
In sum, all medicines all have direct or indirect resisting fatigue and treatment chronic fatigue syndrome, the effect of enhancing immunity in the Herba hylotelephii erythrosticti spirit Chinese medicinal formulae.
We carry out pharmacodynamic experiment research at CFS relevant paathogenic factor and clinical symptoms to the Herba hylotelephii erythrosticti spirit, and the spirit of presentation of results Herba hylotelephii erythrosticti has treating chronic effort syndrome, and the effect of enhancing immunity is the health food that is worth development and use.
The present invention is a kind of determined curative effect, safe and reliable, preparation technology advanced person, dosage form is stable, quality controllable, have be convenient to take, carry, good various advantages of compliance that user is taken, be the health food of special for treating CFS and enhancing immunity, can benefit increasing vast chronic fatigue syndrome (CFS) patient.
The specific embodiment
Embodiment one
The preparation method of Herba hylotelephii erythrosticti spirit sheet:
Get Radix Rhodiolae 750g, Radix Et Caulis Acanthopanacis Senticosi 750g, adding 75% alcohol heating reflux extracts twice, its reflux, extract, heating and temperature control is at 85 ℃, steam pressure is 1.2Mpa, add for the first time 5 times of amount 75% alcohol heating reflux 2 hours, add 4 times of amount 75% alcohol heating reflux 1.5 hours for the second time, merge extractive liquid,, reclaim ethanol and be concentrated into an amount of, standby; Medicinal residues add Ganoderma 750g, decoct with water twice, it decocts temperature and is controlled at 100 ℃, and steam pressure is 1.2Mpa, adds 10 times of water gagings for the first time and decocts 3 hours, adding for the second time 8 times of water gagings decocted 2 hours, collecting decoction filters, and is evaporated to an amount of, two concentrated solutions merging are concentrated into the clear paste that relative density is 1.10-1.30 (80 ℃ of survey), drying is ground into fine powder, adds appropriate amount of starch and makes granule, dry, it is an amount of to add magnesium stearate, and mixing is pressed into 1000, bag film-coat or sugar-coat, every heavy 0.3g.
Embodiment two
The preparation method of Herba hylotelephii erythrosticti granule (containing sucrose):
Get Radix Rhodiolae 750g, Radix Et Caulis Acanthopanacis Senticosi 750g, adding 75% alcohol heating reflux extracts twice, its reflux, extract, heating and temperature control is at 85 ℃, steam pressure is 1.2Mpa, add for the first time 5 times of amount 75% alcohol heating reflux 2 hours, add 4 times of amount 75% alcohol heating reflux 1.5 hours for the second time, merge extractive liquid,, reclaim ethanol and be concentrated into an amount of, standby; Medicinal residues add Ganoderma 750g, decoct with water twice, and it decocts temperature and is controlled at 100 ℃, steam pressure is 1.2Mpa, adds 10 times of water gagings for the first time and decocts 3 hours, adds 8 times of water gagings for the second time and decocts 2 hours, collecting decoction filters, and is evaporated to an amount of, two concentrated solutions merging are concentrated into the clear paste that relative density is 1.10-1.30 (80 ℃ of survey), and qinghuo reagent adds 4 portions of sucrose for 1 part, promptly adds cane sugar powder 1730g, mixing is made granule, drying, make dried granule 2000g, pack, every packed 6g.
Embodiment three
The preparation method of Herba hylotelephii erythrosticti spirit granule (no sucrose):
Get Radix Rhodiolae 750g, Radix Et Caulis Acanthopanacis Senticosi 750g, adding 75% alcohol heating reflux extracts twice, its reflux, extract, heating and temperature control is at 85 ℃, steam pressure is 1.2Mpa, add for the first time 5 times of amount 75% alcohol heating reflux 2 hours, add 4 times of amount 75% alcohol heating reflux 1.5 hours for the second time, merge extractive liquid,, reclaim ethanol and be concentrated into an amount of, standby; Medicinal residues add Ganoderma 750g, decoct with water twice, it decocts temperature and is controlled at 100 ℃, and steam pressure is 1.2Mpa, adds 10 times of water gagings for the first time and decocts 3 hours, adding for the second time 8 times of water gagings decocted 2 hours, collecting decoction filters, and is evaporated to an amount of, two concentrated solutions merging are concentrated into the clear paste that relative density is 1.10-1.30 (80 ℃ of survey), drying is ground into fine powder, adds dextrin 730g, steviosin 1g mixing, use the 20-30% alcohol granulation, drying is made dried granule 1000g, pack, every bag of 3g.
Embodiment four
The preparation method of Herba hylotelephii erythrosticti curing capsule
Get Radix Rhodiolae 750g, Radix Et Caulis Acanthopanacis Senticosi 750g, adding 75% alcohol heating reflux extracts twice, its reflux, extract, heating and temperature control is at 85 ℃, steam pressure is 1.2Mpa, add for the first time 5 times of amount 75% alcohol heating reflux 2 hours, add 4 times of amount 75% alcohol heating reflux 1.5 hours for the second time, merge extractive liquid,, reclaim ethanol and be concentrated into an amount of, standby; Medicinal residues add Ganoderma 750g, decoct with water twice, and it decocts temperature and is controlled at 100 ℃, steam pressure is 1.2Mpa, adds 10 times of water gagings for the first time and decocts 3 hours, adds 8 times of water gagings for the second time and decocts 2 hours, collecting decoction filters, and is evaporated to an amount of, two concentrated solutions merging are concentrated into the clear paste that relative density is 1.10-1.30 (80 ℃ of survey), and drying is ground into fine powder, add magnesium stearate 2.3g, mixing incapsulates, every dress 0.3g
Embodiment five
Herba hylotelephii erythrosticti spirit preparation of soft capsule method:
Get Radix Rhodiolae 750g, Radix Et Caulis Acanthopanacis Senticosi 750g, Ganoderma 750g, Cera Flava 3.33g, vitamin E 0.27g, soybean oil 168g, Radix Rhodiolae 750g, Radix Et Caulis Acanthopanacis Senticosi 750g are added 75% acetic acid hot reflux to be extracted twice, its reflux, extract, heating and temperature control is at 80-90 ℃, steam pressure is 1-1.5Mpa, add for the first time 5 times of amount 75% alcohol heating reflux 2 hours, add 4 times of amount 75% alcohol heating reflux 1.5 hours for the second time, merge extractive liquid,, reclaim ethanol and be concentrated into an amount of, standby; Medicinal residues add Ganoderma 750g, decoct with water twice, and it decocts temperature and is controlled at 100 ℃, and steam pressure is 1-1.5Mpa, add 10 times of water gagings for the first time and decoct 3 hours, add 8 times of water gagings for the second time and decoct 2 hours, and collecting decoction filters.Be evaporated in right amount, add ethanol and make that to contain the alcohol amount be 78%, leave standstill more than 12 hours, being evaporated to relative density is the clear paste of 1.10-1.30 (80 ℃ of surveys), spray drying.Superfine powder is broken into fine powder, gets Herba hylotelephii erythrosticti spirit extract; Extract adds soybean oil 168g, vitamin E 0.27g, Cera Flava 3.33g, grinds evenly with colloid mill, makes capsule-core, with the softgel shell that gelatin 60g, glycerol 18g, water 92g, red ferric oxide 0.6g are mixed with, is pressed into 333 of soft capsules, and every contains the 500mg medicinal liquid.
Embodiment six
The preparation method of Herba hylotelephii erythrosticti spirit mixture (oral liquid)
Get Radix Rhodiolae 750g, Radix Et Caulis Acanthopanacis Senticosi 750g, adding 75% alcohol heating reflux extracts twice, its reflux, extract, heating and temperature control is at 80-90 ℃, steam pressure is 1-1.5Mpa, add for the first time 5 times of amount 75% alcohol heating reflux 2 hours, add 4 times of amount 75% alcohol heating reflux 1.5 hours for the second time, merge extractive liquid,, reclaim ethanol and be concentrated into an amount of, standby; Medicinal residues add Ganoderma 750g, decoct with water twice, and it decocts temperature and is controlled at 100 ℃, and steam pressure is 1-1.5Mpa, add 10 times of water gagings for the first time and decoct 3 hours, add 8 times of water gagings for the second time and decoct 2 hours, and collecting decoction filters.Be evaporated in right amount, it is the clear paste of 1.10-1.30 (80 ℃ of surveys) that two concentrated solutions are merged filtering and concentrating to relative densities, puts cold, adding ethanol, to make the alcohol amount of containing be 70% to stir evenly, and leaves standstill more than 12 hours, filters, filtrate recycling ethanol is not to there being the alcohol flavor, and after adding sodium benzoate 16.65g, the sucrose 333g dissolving, adding distil water is to 3330ml, stir evenly, left standstill 12 hours, and filtered, add distilled water and make into 3330ml, packing, promptly.
Claims (2)
1. Herba hylotelephii erythrosticti spirit Chinese medicine preparation is characterized in that by Radix Rhodiolae, Radix Et Caulis Acanthopanacis Senticosi, Ganoderma and appropriate amount of auxiliary materials formulated; Its prescription is: Radix Rhodiolae 750g, Radix Et Caulis Acanthopanacis Senticosi 750g, Ganoderma 750g and appropriate amount of auxiliary materials preparation.
2. the preparation method of Herba hylotelephii erythrosticti spirit Chinese medicine preparation is characterized in that:
A, Herba hylotelephii erythrosticti spirit sheet
Get Radix Rhodiolae 750g, Radix Et Caulis Acanthopanacis Senticosi 750g, adding 75% alcohol heating reflux extracts twice, its reflux, extract, heating and temperature control is at 80-90 ℃, steam pressure is 1-1.5Mpa, add for the first time 5 times of amount 75% alcohol heating reflux 2 hours, add 4 times of amount 75% alcohol heating reflux 1.5 hours for the second time, merge extractive liquid,, reclaim ethanol and be concentrated into an amount of, standby; Medicinal residues add Ganoderma 750g, decoct with water twice, and it decocts temperature and is controlled at 100 ℃, and steam pressure is 1-1.5Mpa, add 10 times of water gagings for the first time and decoct 3 hours, add 8 times of water gagings for the second time and decoct 2 hours, and collecting decoction filters.Be evaporated in right amount, two concentrated solutions merging are concentrated into the clear paste that relative density is 1.10-1.30 (80 ℃ of survey), drying is ground into fine powder, and add appropriate amount of starch and make granule, drying, the adding magnesium stearate is an amount of, mixing, compacting is in blocks;
B, Herba hylotelephii erythrosticti spirit granule (containing sucrose)
Get Radix Rhodiolae 750g, Radix Et Caulis Acanthopanacis Senticosi 750g, adding 75% alcohol heating reflux extracts twice, its reflux, extract, heating and temperature control is at 80-90 ℃, steam pressure is 1-1.5Mpa, add for the first time 5 times of amount 75% alcohol heating reflux 2 hours, add 4 times of amount 75% alcohol heating reflux 1.5 hours for the second time, merge extractive liquid,, reclaim ethanol and be concentrated into an amount of, standby; Medicinal residues add Ganoderma 750g, decoct with water twice, and it decocts temperature and is controlled at 100 ℃, steam pressure is 1-1.5Mpa, adds 10 times of water gagings for the first time and decocts 3 hours, adds 8 times of water gagings for the second time and decocts 2 hours, collecting decoction, filter, be evaporated in right amount, two concentrated solutions merging are concentrated into the clear paste that relative density is 1.10-1.30 (80 ℃ of survey), 1 part and 4 portions sucrose of qinghuo reagent, mixing is made granule, drying;
C, Herba hylotelephii erythrosticti spirit granule (no sucrose)
Get Radix Rhodiolae 750g, Radix Et Caulis Acanthopanacis Senticosi 750g, adding 75% alcohol heating reflux extracts twice, its reflux, extract, heating and temperature control is at 80-90 ℃, steam pressure is 1-1.5Mpa, add for the first time 5 times of amount 75% alcohol heating reflux 2 hours, add 4 times of amount 75% alcohol heating reflux 1.5 hours for the second time, merge extractive liquid,, reclaim ethanol and be concentrated into an amount of, standby; Medicinal residues add Ganoderma 750g, decoct with water twice, and it decocts temperature and is controlled at 100 ℃, steam pressure is 1-1.5Mpa, adds 10 times of water gagings for the first time and decocts 3 hours, adds 8 times of water gagings for the second time and decocts 2 hours, collecting decoction filters, and is evaporated to an amount of, two concentrated solutions merging are concentrated into the clear paste that relative density is 1.10-1.30 (80 ℃ of survey), and drying is ground into fine powder, add dextrin 730g, steviosin 1g mixing is used the 20-30% alcohol granulation, drying;
D, Herba hylotelephii erythrosticti curing capsule
Get Radix Rhodiolae 750g, Radix Et Caulis Acanthopanacis Senticosi 750g, adding 75% alcohol heating reflux extracts twice, its reflux, extract, heating and temperature control is at 80-90 ℃, steam pressure is 1-1.5Mpa, add for the first time 5 times of amount 75% alcohol heating reflux 2 hours, add 4 times of amount 75% alcohol heating reflux 1.5 hours for the second time, merge extractive liquid,, reclaim ethanol and be concentrated into an amount of, standby; Medicinal residues add Ganoderma 750g, decoct with water twice, and it decocts temperature and is controlled at 100 ℃, and steam pressure is 1-1.5Mpa, add 10 times of water gagings for the first time and decoct 3 hours, add 8 times of water gagings for the second time and decoct 2 hours, and collecting decoction filters; Be evaporated in right amount, two concentrated solutions merging are concentrated into the clear paste that relative density is 1.10-1.30 (80 ℃ of survey), drying is ground into fine powder, adds magnesium stearate 2.3g, and mixing incapsulates;
E, Herba hylotelephii erythrosticti spirit soft capsule
Get Radix Rhodiolae 750g, Radix Et Caulis Acanthopanacis Senticosi 750g, Ganoderma 750g, Cera Flava 3.33g, vitamin E 0.27g, soybean oil 168g, Radix Rhodiolae 750g, Radix Et Caulis Acanthopanacis Senticosi 750g are added 75% acetic acid hot reflux to be extracted twice, its reflux, extract, heating and temperature control is at 80-90 ℃, steam pressure is 1-1.5Mpa, add for the first time 5 times of amount 75% alcohol heating reflux 2 hours, add 4 times of amount 75% alcohol heating reflux 1.5 hours for the second time, merge extractive liquid,, reclaim ethanol and be concentrated into an amount of, standby; Medicinal residues add Ganoderma 750g, decoct with water twice, and it decocts temperature and is controlled at 100 ℃, and steam pressure is 1-1.5Mpa, add 10 times of water gagings for the first time and decoct 3 hours, add 8 times of water gagings for the second time and decoct 2 hours, and collecting decoction filters.Be evaporated in right amount, add ethanol and make that to contain the alcohol amount be 78%, leave standstill more than 12 hours, being evaporated to relative density is the clear paste of 1.10-1.30 (80 ℃ of surveys), spray drying; Superfine powder is broken into fine powder, gets Herba hylotelephii erythrosticti spirit extract; Extract adds soybean oil 168g, vitamin E 0.27g, Cera Flava 3.33g, grinds evenly with colloid mill, makes capsule-core, and the softgel shell that is mixed with gelatin, glycerol, water, red ferric oxide is pressed into soft capsule;
G, Herba hylotelephii erythrosticti spirit mixture (oral liquid)
Get Radix Rhodiolae 750g, Radix Et Caulis Acanthopanacis Senticosi 750g, adding 75% alcohol heating reflux extracts twice, its reflux, extract, heating and temperature control is at 80-90 ℃, steam pressure is 1-1.5Mpa, add for the first time 5 times of amount 75% alcohol heating reflux 2 hours, add 4 times of amount 75% alcohol heating reflux 1.5 hours for the second time, merge extractive liquid,, reclaim ethanol and be concentrated into an amount of, standby; Medicinal residues add Ganoderma 750g, decoct with water twice, and it decocts temperature and is controlled at 100 ℃, and steam pressure is 1-1.5Mpa, add 10 times of water gagings for the first time and decoct 3 hours, add 8 times of water gagings for the second time and decoct 2 hours, and collecting decoction filters; Be evaporated to an amount of, it is the clear paste of 1.10-1.30 (80 ℃ of surveys) that two concentrated solutions are merged filtering and concentrating to relative densities, puts coldly, adds ethanol and makes that to contain the alcohol amount be 70% to stir evenly, leave standstill more than 12 hours, filter, filtrate recycling ethanol is not to there being the alcohol flavor, add stupid sodium formate, sucrose dissolved after, adding distil water, stir evenly, left standstill 12 hours, filter.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103815086A (en) * | 2012-11-16 | 2014-05-28 | 郭天伊 | Preparation method of lucid ganoderma health tea |
| CN104013665A (en) * | 2014-06-20 | 2014-09-03 | 苏州法莫生物技术有限公司 | Preparation containing maca |
| CN105124584A (en) * | 2015-09-14 | 2015-12-09 | 广西经正科技开发有限责任公司 | Dendrobium officinale compound health-care oral solution and preparation method thereof |
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| CN1415376A (en) * | 2002-11-21 | 2003-05-07 | 冯玉书 | Chinese medicinal compound preparation for treating chronic fatigue syndrome and preparation process thereof |
| CN101278730A (en) * | 2008-04-07 | 2008-10-08 | 孙荣高 | Preparation of ganoderma lucidum rhodiola rosea oral liquid |
| CN101433630A (en) * | 2007-11-16 | 2009-05-20 | 北京因科瑞斯医药科技有限公司 | Antiradiation composition for improving immunity and preparation method thereof |
| CN101524176A (en) * | 2009-04-07 | 2009-09-09 | 北京康比特体育科技股份有限公司 | Beverage for supplementing physical ability |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1415376A (en) * | 2002-11-21 | 2003-05-07 | 冯玉书 | Chinese medicinal compound preparation for treating chronic fatigue syndrome and preparation process thereof |
| CN101433630A (en) * | 2007-11-16 | 2009-05-20 | 北京因科瑞斯医药科技有限公司 | Antiradiation composition for improving immunity and preparation method thereof |
| CN101278730A (en) * | 2008-04-07 | 2008-10-08 | 孙荣高 | Preparation of ganoderma lucidum rhodiola rosea oral liquid |
| CN101524176A (en) * | 2009-04-07 | 2009-09-09 | 北京康比特体育科技股份有限公司 | Beverage for supplementing physical ability |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103815086A (en) * | 2012-11-16 | 2014-05-28 | 郭天伊 | Preparation method of lucid ganoderma health tea |
| CN104013665A (en) * | 2014-06-20 | 2014-09-03 | 苏州法莫生物技术有限公司 | Preparation containing maca |
| CN105124584A (en) * | 2015-09-14 | 2015-12-09 | 广西经正科技开发有限责任公司 | Dendrobium officinale compound health-care oral solution and preparation method thereof |
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Application publication date: 20110406 |