CN101152491B - Alopecia treating medicine, preparing method and uses of the same - Google Patents
Alopecia treating medicine, preparing method and uses of the same Download PDFInfo
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- CN101152491B CN101152491B CN2007101810222A CN200710181022A CN101152491B CN 101152491 B CN101152491 B CN 101152491B CN 2007101810222 A CN2007101810222 A CN 2007101810222A CN 200710181022 A CN200710181022 A CN 200710181022A CN 101152491 B CN101152491 B CN 101152491B
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Abstract
The present invention relates to a medicine for curing alopecia and the preparation method and purpose; the raw materials for preparing the medicines are medicinal medlar, prepared rhizome of rehmannia, tube of multiflower knotweed, glossy privet fruit, cornel, yam, herb of yerbadetajo, Tuckahoe, oriental water plantain rhizome, moutan bark and sticky rice; the auxiliary materials are alcohol andhoney; a small amount of vitamin A is added in the effective components; the raw materials are mixed and immersed in the alcohol; and then the mixture is mixed and compressed to extract the alcohol solution; the alcohol solution is put in a sealed container with consistent temperature and then the pressure is reduced and the alcohol solution is distilled to remove the alcohol which is used as themenstruum; the medicine obtained is made into pill, capsule or troche with conventional preparation method. The oral medicine can yield obvious curative effect in a short time; the medicine is innocuous and has no side effect; moreover, the price is low and the curative effect is obvious; in this way, the medicine is fit for consumers of various strata.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of alopecia and its production and use.
Background technology
Alopecia is a kind of common disease, and the male just has a hair loss patient more than the women in per approximately 34 among the male more than 30 years old; The women is less, and the adult female has a patient in 800.Due to existing medical institutions think all that with regard to its medicine for treatment basis the scalp fat secretion too much, the just normal seborrheic alopecia of saying, but find through further investigation for many years, alopecia and perspiration oils and fats be heavier not to have too many direct relation, and the people that the perspiration oils and fats is heavier needs only the permeability that hair washing in per two days once just can guarantee pore substantially.Compare discovery at the various actual cases of a large amount of prescription on individual diagnosis patients: alopecia and seborrhea do not have direct relation, patient's alopecia is caused that by body interior organ imbalance of YIN and YANG or interior environment imbalance main classification has six big classes such as blood deficiency, the deficiency of YIN, smart void, the deficiency of vital energy, yang deficiency, endocrine disturbance.Now the employed therapy of each medical institutions has four kinds: a kind of for the direct administration of pore, medicine directly is applied in root of hair, and this kind therapy is for curing the symptoms, not the disease, and do not have which kind of medicine and can really make hair restoration, and anti-avulsion does not have obvious curative effects yet; Second kind is medicine for oral administration, and price is extremely expensive, month then thousands of units of expense, but which kind of medicine also not on the books has effect clearly; The third is oral administration and externally used, states according to each patient, has eaten and has smeared, and has smeared and has eaten, and whose hair is many time results that turned from side to side do not have has yet been fallen and grown; The 4th kind is unique effective Therapeutic Method, carries out scalp and transplants, and hair is to have had after transplanting, but the plantation scalp does not have nerve, does not have neural scalp can imagine it is a kind of what sensation.
The present invention is through for many years experimental study, a kind of oral medicine for the treatment of alopecia is provided, its active ingredient is that Chinese medicine preparation adds a spot of vitamin A, can fully play the effect that activates hair follicle cell, can in the relatively short time, the obvious treatment effect be arranged, without any side effects, cheap and curative effect is obvious, be applicable to that each patient of stratum consumes use.
Summary of the invention
The object of the invention is, a kind of medicine for the treatment of alopecia and its production and use is provided, this medicine is by the crude drug Fructus Lycii, Radix Rehmanniae Preparata, Radix Polygoni Multiflori, Fructus Ligustri Lucidi, Fructus Corni, Rhizoma Dioscoreae, Herba Ecliptae, Poria, Rhizoma Alismatis, Cortex Moutan and Oryza glutinosa, adjuvant is ethanol and Mel, and in its active ingredient, add a spot of vitamin A, employing mixes crude drug, alcohol-pickled, stir, alcoholic solution, constant temperature in the hermetic container of again alcoholic solution being packed into are extracted in squeezing, decompression, extraction solvent ethanol is removed in distillation, the active ingredient of last gained medical material add Mel routinely pharmaceutical methods make pill or routinely pharmaceutical methods make capsule or tablet.This oral medicine can have the obvious treatment effect without any side effects in the relatively short time, and is cheap and curative effect is obvious, is applicable to that each patient of stratum consumes use.
A kind of medicine for the treatment of alopecia of the present invention, this medicine is by crude drug Fructus Lycii 10g-60g, Radix Rehmanniae Preparata 15g-70g, Radix Polygoni Multiflori 20g-80g, Fructus Ligustri Lucidi 10g-55g, Fructus Corni 15g-80g, Rhizoma Dioscoreae 30g-80g, Herba Ecliptae 20g-55g, Poria 10g-55g, Rhizoma Alismatis 10g-60g, Cortex Moutan 15g-60g, Oryza glutinosa 20g-80g and vitamin A 5-12 ten thousand units, adjuvant is 43-68%v/v ethanol 600-11000ml, Mel 20-48g makes, employing mixes crude drug, alcohol-pickled, stir, alcoholic solution is extracted in squeezing, the constant temperature in the hermetic container of again alcoholic solution being packed into, decompression, distillation, remove solvent ethanol, last gained medical material active ingredient add again vitamin A admix Mel routinely pharmaceutical methods make pill or routinely pharmaceutical methods make capsule or tablet.
Described medicine, proportion optimization is: Fructus Lycii 20-60g, Radix Rehmanniae Preparata 20-60g, Radix Polygoni Multiflori 25-75g, Fructus Ligustri Lucidi 20-50g, Fructus Corni 25-75g, Rhizoma Dioscoreae 45-75g, Herba Ecliptae 20-45g, Poria 10-50g, Rhizoma Alismatis 10-50g, Cortex Moutan 30-55g, Oryza glutinosa 35-70g and vitamin A 7-10 ten thousand units, adjuvant 48-53%v/v ethanol 3250-5500ml, Mel 20-45g.
Described medicine, proportioning is preferably once more: Fructus Lycii 30-50g, Radix Rehmanniae Preparata 30-50g, Radix Polygoni Multiflori 30-50g, Fructus Ligustri Lucidi 30-50g, Fructus Corni 30-60g, Rhizoma Dioscoreae 30-60g, Herba Ecliptae 30-50g, Poria 10-40g, Rhizoma Alismatis 10-40g, Cortex Moutan 25-40g, Oryza glutinosa 30-50g and vitamin A 7-8 ten thousand units, adjuvant 48-53%v/v ethanol 2500-5000ml, Mel 25-40g.
Described medicine, proportioning the best is preferably: get Fructus Lycii 50g, Radix Rehmanniae Preparata 30g, Radix Polygoni Multiflori 50g, Fructus Ligustri Lucidi 50g, Fructus Corni 30g, Rhizoma Dioscoreae 30g, Herba Ecliptae 50g, Poria 10g, Rhizoma Alismatis 10g, Cortex Moutan 20g, Oryza glutinosa 50g and vitamin A 7.5 ten thousand units, adjuvant 53%v/v ethanol 4500ml, Mel 42g.
The preparation method of described medicine follows these steps to carry out:
A, crude drug Fructus Lycii, Radix Rehmanniae Preparata, Radix Polygoni Multiflori, Fructus Ligustri Lucidi, Fructus Corni, Rhizoma Dioscoreae, Herba Ecliptae, Poria, Rhizoma Alismatis, Cortex Moutan and Oryza glutinosa are mixed;
B, adding 43-68%v/v ethanol 600-11000ml soak, and stir once in per 3 days, take out squeezing after 25 days, extract alcoholic solution;
C, alcoholic solution is packed in the hermetic container, 40 ℃ of constant temperature of temperature, distilling under reduced pressure, remove solvent ethanol wherein, last gained medical material active ingredient powder add vitamin A 5-12 ten thousand units admix Mel 20-48g routinely pharmaceutical methods make pill or routinely pharmaceutical methods make capsule or tablet.
Described medicine is as the purposes of the medicine of preparation treatment alopecia and prevention alopecia.
A kind of medication principle for the treatment of the medicine of alopecia of the present invention:
We at first are used as medicine with Fructus Lycii, Radix Rehmanniae Preparata, Radix Polygoni Multiflori, Fructus Ligustri Lucidi, Fructus Corni, Rhizoma Dioscoreae, be aided with Herba Ecliptae, Poria, Rhizoma Alismatis, Cortex Moutan, Oryza glutinosa and vitamin A, Fructus Lycii liver and kidney tonifying wherein, lay particular emphasis on nourishing the liver, function promotes liver cell regeneration, purify liver and whole body blood vessel, and supporing yang effect is arranged; The Radix Rehmanniae Preparata nourishing YIN to lower pathogenic fire nourishes blood and enriches blood, and function is improved the heart vigor; The Radix Polygoni Multiflori blood enriching and generation of vital essence promoting, function heart tonifying and anti-arteries are atherosis; Fructus Ligustri Lucidi, the strong liver kidney tonifying of Fructus Corni, liver and kidney tonifying is cloudy, and thanks to the strong body of function is disease-resistant.Rhizoma Dioscoreae spleen reinforcing nourishing the stomach, the liver benefiting reinforces the kidney, the function QI invigorating; Herba Ecliptae the liver and the kidney tonifying, removing heat from blood, function tonifying the lung the moon; Poria spleen invigorating mind calming, eliminating dampness and diuresis, function protects the liver; The Rhizoma Alismatis lung that clears away heart-fire is let out the kidney fire; The Cortex Moutan clearing away heat and cooling blood, promoting blood circulation and detoxication; Flat, the sweet in the mouth of Oryza glutinosa, Yin-nourishing and Yang-supporting, the long-pending removing heat from blood of row, current 12 warps help the merit of drug effect, and vitamin A can effectively be protected deckzelle.In sum, we have comprehensive health preserving effect, can fundamentally solve the cause of disease of alopecia, the cause of disease of alopecia does not exist the back hair promptly no longer to fall, the resulting nutrition of natural hair follicle also can make moderate progress after environment improved in the health, as all medicines such as Radix Polygoni Multiflori, Herba Ecliptae, Fructus Ligustri Lucidi trichogenous effect is arranged again, Guyuan has the hair follicle that fails to be activated to regenerate New Development in addition.
A kind of pathological analysis for the treatment of the medicine of alopecia of the present invention:
Alopecia is a kind of common property disease, according to incompletely statistics, in existing average 30 four-players of man more than 30 years old people's alopecia is just arranged, and also there is considerable part people alopecia in 30 years old adolescence more than 20 years old.Add up according to receiving among the patient at ordinary times, it is varied to study carefully its alopecia reason, and wherein the most representative have four big classes; One, a little less than the blood-deficiency type alopecia, the most body constitution of this type of patient, hair is withered, and gastrointestinal function is relatively poor, and alopecia is former because the nutrition supply deficiency; Two, deficiency of YIN alopecia, this class patient is general, and libido is stronger, and is former in depletion fire syndrome going up, and this type of patient's alopecia is former because hair is lost by fire; Three, endocrine disturbance's alopecia, this class patient do not have enough sleep mostly, easily insomnia, and part patient is due to the brain overwork, and this type of patient's alopecia reason is that root of hair can not get the required nutrient substance of natural on-off cycles of hair growth; Four, decline property alopecia, this class patient generally shows as senilism, not only shows as alopecia, and sexual function, gastrointestinal function, vision, audition all show as functional deterioration, and reason differs, and the deficiency of vital energy, smart void, yang deficiency etc. are arranged, and alopecia is former because the hair follicle degeneration.To sum up 4 described, problem has appearred in the hair loss patient internal medium, set about a little should be from mediator's internal milieu in treatment.
The specific embodiment
Embodiment 1
Get Fructus Lycii 10g, Radix Rehmanniae Preparata 15g, Radix Polygoni Multiflori 20g, Fructus Ligustri Lucidi 10g, Fructus Corni 15g, Rhizoma Dioscoreae 30g, Herba Ecliptae 20g, Poria 10g, Rhizoma Alismatis 10g, Cortex Moutan 15g, Oryza glutinosa 20g mixing, adding 43%v/v ethanol 600ml soaks, stirred once in per three days, take out squeezing after 25 days and extract alcoholic solution, alcoholic solution packed into carry out 40 ℃ of constant temperature distilling under reduced pressure in the hermetic container, remove solvent ethanol, the vitamin A of gained medical material active ingredient powder adding at last 50,000 units admix makes pill according to a conventional method among the Mel 20g.
Using method: take 6 balls every day, yellow wine 50g takes, and once-a-day, takes during supper; One month one course of treatment, after two courses of treatment can the next day take once, the lighter fully recovers for three courses of treatment, moderate alopecia person fully recovers for six courses of treatment, severe alopecia person fully recovers needed for 12 courses of treatment.
Embodiment 2
Get Fructus Lycii 30g, Radix Rehmanniae Preparata 50g, Radix Polygoni Multiflori 50g, Fructus Ligustri Lucidi 30g, Fructus Corni 50g, Rhizoma Dioscoreae 50g, Herba Ecliptae 40g, Poria 35g, Rhizoma Alismatis 35g, Cortex Moutan 50g, Oryza glutinosa 35g mixing, adding 48%v/v ethanol 3700ml soaks, stirred once in per three days, take out squeezing after 25 days and extract alcoholic solution, alcoholic solution packed into carry out 40 ℃ of constant temperature distilling under reduced pressure in the hermetic container, remove solvent ethanol, tablet is made by the vitamin A of gained medical material active ingredient powder adding at last 80,000 units pharmaceutical methods method routinely.
Using method: take 3 every day, yellow wine 50g takes, and once-a-day, takes during supper; One month one course of treatment, after two courses of treatment can the next day take once, the lighter fully recovers for three courses of treatment, moderate alopecia person fully recovers for six courses of treatment, severe alopecia person fully recovers needed for 12 courses of treatment.
Embodiment 3
Get Fructus Lycii 60g, Radix Rehmanniae Preparata 70g, Radix Polygoni Multiflori 80g, Fructus Ligustri Lucidi 55g, Fructus Corni 80g, Rhizoma Dioscoreae 80g, Herba Ecliptae 55g, Poria 55g, Rhizoma Alismatis 605g, Cortex Moutan 60g, Oryza glutinosa 80g mixing, adding 68%v/v ethanol 11000ml soaks, stirred once in per three days, take out after 25 days and squeeze alcoholic solution, alcoholic solution packed into carry out 40 ℃ of constant temperature distilling under reduced pressure in the hermetic container, remove extraction solvent ethanol, last gained medical material active ingredient powder adds retinol1 20,000 units, admixes and makes pill among the Mel 48g according to a conventional method.
Using method: take 6 balls every day, yellow wine 50g takes, and once-a-day, takes during supper; One month one course of treatment, after two courses of treatment can the next day take once, the lighter fully recovers for three courses of treatment, moderate alopecia person fully recovers for six courses of treatment, severe alopecia person fully recovers needed for 12 courses of treatment.
Embodiment 4
Fructus Lycii 20g, Radix Rehmanniae Preparata 20g, Radix Polygoni Multiflori 25g, Fructus Ligustri Lucidi 20g, Fructus Corni 25g, Rhizoma Dioscoreae 45g, Herba Ecliptae 20g, Poria 10g, Rhizoma Alismatis 10g, Cortex Moutan 30g, Oryza glutinosa 35g mix, adding adjuvant 48%v/v ethanol 3250ml soaks, stirred once in per three days, take out squeezing after 25 days and extract alcoholic solution, alcoholic solution packed into carry out 40 ℃ of constant temperature distilling under reduced pressure in the hermetic container, remove solvent ethanol, last gained medical material active ingredient powder add vitamin A 70,000 units admix Mel 30g routinely pharmaceutical methods make pill.
Using method: take 6 balls every day, yellow wine 50g takes, and once-a-day, takes during supper; One month one course of treatment, after two courses of treatment can the next day take once, the lighter fully recovers for three courses of treatment, moderate alopecia person fully recovers for six courses of treatment, severe alopecia person fully recovers needed for 12 courses of treatment.
Embodiment 5
Fructus Lycii 35g, Radix Rehmanniae Preparata 35g, Radix Polygoni Multiflori 45g, Fructus Ligustri Lucidi 30g, Fructus Corni 55g, Rhizoma Dioscoreae 60g, Herba Ecliptae 30g, Poria 35g, Rhizoma Alismatis 35g, Cortex Moutan 45g, Oryza glutinosa 50g mix, adding adjuvant 50%v/v ethanol 4250ml soaks, stirred once in per three days, take out after 25 days, alcoholic solution is extracted in squeezing, alcoholic solution packed into carry out 40 ℃ of constant temperature distilling under reduced pressure in the hermetic container, remove solvent ethanol, last gained medical material active ingredient powder adds vitamin A 90,000 units, and pharmaceutical methods is made capsule routinely.
Using method: take 3 every day, yellow wine 50g takes, and once-a-day, takes during supper; One month one course of treatment, after two courses of treatment can the next day take once, the lighter fully recovers for three courses of treatment, moderate alopecia person fully recovers for six courses of treatment, severe alopecia person fully recovers needed for 12 courses of treatment.
Embodiment 6
Fructus Lycii 60g, Radix Rehmanniae Preparata 60g, Radix Polygoni Multiflori 75g, Fructus Ligustri Lucidi 50g, Fructus Corni 75g, Rhizoma Dioscoreae 75g, Herba Ecliptae 45g, Poria 50g, Rhizoma Alismatis 50g, Cortex Moutan 55g, Oryza glutinosa 70g mix, adding adjuvant 53%v/v ethanol 5500ml soaks, stirred once in per three days, take out squeezing after 25 days and extract alcoholic solution, alcoholic solution packed into carry out 40 ℃ of constant temperature distilling under reduced pressure in the hermetic container, remove solvent ethanol, tablet is made by the retinol1 of gained medical material active ingredient powder adding at last 00,000 units pharmaceutical methods routinely.
Using method: take 3 every day, yellow wine 50g takes, and once-a-day, takes during supper; One month one course of treatment, after two courses of treatment can the next day take once, the lighter fully recovers for three courses of treatment, moderate alopecia person fully recovers for six courses of treatment, severe alopecia person fully recovers needed for 12 courses of treatment.
Embodiment 7
Fructus Lycii 30g, Radix Rehmanniae Preparata 30g, Radix Polygoni Multiflori 30g, Fructus Ligustri Lucidi 30g, Fructus Corni 30g, Rhizoma Dioscoreae 30g, Herba Ecliptae 30g, Poria 10g, Rhizoma Alismatis 10g, Cortex Moutan 25g, Oryza glutinosa 30g mix, add adjuvant 48%v/v ethanol 2500ml, soak, stirred once in per three days, take out squeezing after 25 days and extract alcoholic solution, alcoholic solution packed into carry out 40 ℃ of constant temperature distilling under reduced pressure in the hermetic container, remove solvent ethanol, last gained medical material active ingredient powder add vitamin A 70,000 units admix Mel 25g routinely pharmaceutical methods make pill.
Using method: take 6 balls every day, yellow wine 50g takes, and once-a-day, takes during supper; One month one course of treatment, after two courses of treatment can the next day take once, the lighter fully recovers for three courses of treatment, moderate alopecia person fully recovers for six courses of treatment, severe alopecia person fully recovers needed for 12 courses of treatment.
Embodiment 8
Fructus Lycii 40g, Radix Rehmanniae Preparata 35g, Radix Polygoni Multiflori 35g, Fructus Ligustri Lucidi 40g, Fructus Corni 45g, Rhizoma Dioscoreae 45g, Herba Ecliptae 40g, Poria 30g, Rhizoma Alismatis 30g, Cortex Moutan 35g, Oryza glutinosa 40g mix, add adjuvant 50%v/v ethanol 3500ml, soak, stirred once in per three days, take out squeezing after 25 days and extract alcoholic solution, alcoholic solution packed into carry out 40 ℃ of constant temperature distilling under reduced pressure in the hermetic container, remove solvent ethanol, last gained medical material active ingredient powder add vitamin A 7.5 ten thousand units admix Mel 45g routinely pharmaceutical methods make tablet.
Using method: take 6 balls every day, yellow wine 50g takes, and once-a-day, takes during supper; One month one course of treatment, after two courses of treatment can the next day take once, the lighter fully recovers for three courses of treatment, moderate alopecia person fully recovers for six courses of treatment, severe alopecia person fully recovers needed for 12 courses of treatment.。
Embodiment 9
Fructus Lycii 50g, Radix Rehmanniae Preparata 50g, Radix Polygoni Multiflori 50g, Fructus Ligustri Lucidi 50g, Fructus Corni 60g, Rhizoma Dioscoreae 60g, Herba Ecliptae 50g, Poria 40g, Rhizoma Alismatis 40g, Cortex Moutan 40g, Oryza glutinosa 50g mix, adjuvant 53%v/v ethanol 5000ml, soak, stirred once in per three days, take out squeezing after 25 days and extract alcoholic solution, alcoholic solution packed into carry out 40 ℃ of constant temperature distilling under reduced pressure in the hermetic container, remove solvent ethanol, tablet is made by the vitamin A of gained medical material active ingredient powder adding at last 80,000 units pharmaceutical methods routinely.
Using method: take 3 every day, yellow wine 50g takes, and once-a-day, takes during supper; One month one course of treatment, after two courses of treatment can the next day take once, the lighter fully recovers for three courses of treatment, moderate alopecia person fully recovers for six courses of treatment, severe alopecia person fully recovers needed for 12 courses of treatment.。
Embodiment 10
Fructus Lycii 50g, Radix Rehmanniae Preparata 30g, Radix Polygoni Multiflori 50g, Fructus Ligustri Lucidi 50g, Fructus Corni 30g, Rhizoma Dioscoreae 30g, Herba Ecliptae 50g, Poria 10g, Rhizoma Alismatis 10g, Cortex Moutan 20g, Oryza glutinosa 50g mix, adding adjuvant 53%v/v ethanol 4500ml soaks, stirred once in per three days, take out squeezing after 25 days and extract alcoholic solution, alcoholic solution packed into carry out 40 ℃ of constant temperature distilling under reduced pressure in the hermetic container, remove solvent ethanol, last gained medical material active ingredient powder add vitamin A 7.5 ten thousand units admix Mel 42g routinely pharmaceutical methods make pill.
Using method: take 6 balls every day, yellow wine 50g takes, and once-a-day, takes during supper; One month one course of treatment, after two courses of treatment can the next day take once, the lighter fully recovers for three courses of treatment, moderate alopecia person fully recovers for six courses of treatment, severe alopecia person fully recovers needed for 12 courses of treatment.
Embodiment 11
Medicine of the present invention is treated the zoopery of the alopecia and the purposes of the medicine of prevention alopecia as preparation:
Toxicity test:
Experiment is prepared:
1, grow up three of rat are listed respectively and do first, second, third numbering, from feeding no longer in morning on November 21st, 2006.
2, getting this medicament potion extracts from adding on October 28th, 2006 53%V/V ethanol 3000ml, take out alcoholic solution 2300ml on November 20th, 2006 and carry out 40 ℃ of constant temperature distilling under reduced pressure, get last residual powder and add pure water 300ml and mix all, respectively get three parts of 25ml add respectively Mel 3 restrain mix all stand-by.
3,3 mm dias are irritated stomach device three covers.
Experimental record:
1,15:00 white mouse on the 21st first filling November in 2006 stomach device installs, and adds prefabricated medicinal liquid 25ml and mixes up flow velocity and carry out drip irrigation.
2,15:13 white mouse on the 21st second filling November in 2006 stomach device installs, and adds prefabricated medicinal liquid 25ml and mixes up flow velocity and carry out drip irrigation.
3, on November 21st, 2006, the 15:29 white mouse third filling stomach device installed, and added prefabricated medicinal liquid 25ml and mixed up flow velocity and carry out drip irrigation.
4, November in 2006,16:06 white mouse on the 21st first was irritated food end, freedom of movement, had no adverse reaction.
5, November in 2006,16:11 white mouse on the 21st second was irritated food end, freedom of movement, had no adverse reaction.
6, the 16:42 white mouse third filling food end on November 21st, 2006, freedom of movement have no adverse reaction.
7, November in 2006 18:27 white mouse on the 21st second defecation, feces is black, hardness is normal; The white mouse integral status is normal, and spiritual gas is pure, has no adverse reaction.
8, November in 2006 19:13 white mouse on the 21st first defecation, feces is black, hardness is normal; The white mouse integral status is normal, and spiritual gas is pure, has no adverse reaction.
9, November in 2006 20:00 white mouse on the 21st first, second, third feeding simultaneously, appetite is normal, has no adverse reaction.
10, on November 21st, 2006 20:16 white mouse third defecation, feces is soft thick shapeless, brown, the folder black particle; The white mouse integral status is normal, and spiritual gas is pure, has no adverse reaction.
11, November in 2006 20:43 white mouse on the 21st first defecation, feces is soft partially, brown; Spirit is pure, has no adverse reaction.
12, on November 21st, 2006 21:03 white mouse third defecation, feces is soft partially, brown is the linear particles shape; Spirit is pure, has no adverse reaction.
13, November in 2006 21:17 white mouse on the 21st second defecation, feces becomes water quality folder brown granule, spirit is normal, has no adverse reaction.
14, November in 2006 21:48 white mouse on the 21st first defecation, feces is pitchy, graininess, hardness is normal; The white mouse integral status is normal, and spiritual gas is pure, has no adverse reaction.
15, November in 2006 22:20 white mouse on the 21st first, second, third feeding simultaneously, appetite is normal, has no adverse reaction.
16, November in 2006 22:29 white mouse on the 21st second defecation, feces is pitchy, graininess, hardness is normal; The white mouse integral status is normal, and spiritual gas is pure, has no adverse reaction.
17, on November 21st, 2006 23:04 white mouse third defecation, feces is pitchy, graininess, hardness is normal; The white mouse integral status is normal, and spiritual gas is pure, has no adverse reaction.
18, on November 21st, 2006,23:30 first, second, the third three white mouse mental status were good, had no adverse reaction.Finish in this experiment field.
Experiment conclusion: drug safety is reliable, does not have any toxicity, side effect.
Claims (6)
1. medicine for the treatment of alopecia, it is characterized in that this medicine is by crude drug Fructus Lycii 10g-60g, Radix Rehmanniae Preparata 15g-70g, Radix Polygoni Multiflori 20g-80g, Fructus Ligustri Lucidi 10g-55g, Fructus Corni 15g-80g, Rhizoma Dioscoreae 30g-80g, Herba Ecliptae 20g-55g, Poria 10g-55g, Rhizoma Alismatis 10g-60g, Cortex Moutan 15g-60g, Oryza glutinosa 20g-80g and vitamin A 5-12 ten thousand units, adjuvant is 43-68%v/v ethanol 600-11000ml, Mel 20-48g makes, employing mixes crude drug, add alcohol-pickled, stirred once in per three days, take out squeezing after 25 days, extract alcoholic solution, again alcoholic solution is packed into and carry out 40 ℃ of constant temperature in the hermetic container, decompression, distillation, remove solvent ethanol, last gained medical material active ingredient adds vitamin A again, admix Mel, routinely pharmaceutical methods make pill or routinely pharmaceutical methods make capsule or tablet.
2. medicine according to claim 1, the proportion optimization that it is characterized in that crude drug is: Fructus Lycii 20-60g, Radix Rehmanniae Preparata 20-60g, Radix Polygoni Multiflori 25-75g, Fructus Ligustri Lucidi 20-50g, Fructus Corni 25-75g, Rhizoma Dioscoreae 45-75g, Herba Ecliptae 20-45g, Poria 10-50g, Rhizoma Alismatis 10-50g, Cortex Moutan 30-55g, Oryza glutinosa 35-70g and vitamin A 7-10 ten thousand units, adjuvant 48-53%v/v ethanol 3250-5500ml, Mel 20-45g.
3. medicine according to claim 1, the proportioning that it is characterized in that crude drug is preferably once more: Fructus Lycii 30-50g, Radix Rehmanniae Preparata 30-50g, Radix Polygoni Multiflori 30-50g, Fructus Ligustri Lucidi 30-50g, Fructus Corni 30-60g, Rhizoma Dioscoreae 30-60g, Herba Ecliptae 30-50g, Poria 10-40g, Rhizoma Alismatis 10-40g, Cortex Moutan 25-40g, Oryza glutinosa 30-50g and vitamin A 7-8 ten thousand units, adjuvant 48-53%v/v ethanol 2500-5000ml, Mel 25-40g.
4. medicine according to claim 1, the proportioning the best that it is characterized in that crude drug is preferably: get Fructus Lycii 50g, Radix Rehmanniae Preparata 30g, Radix Polygoni Multiflori 50g, Fructus Ligustri Lucidi 50g, Fructus Corni 30g, Rhizoma Dioscoreae 30g, Herba Ecliptae 50g, Poria 10g, Rhizoma Alismatis 10g, Cortex Moutan 20g, Oryza glutinosa 50g and vitamin A 7.5 ten thousand units, adjuvant 53%v/v ethanol 4500ml, Mel 42g.
5. according to the preparation method of the described medicine of claim 1, it is characterized in that following these steps to carrying out:
A, crude drug Fructus Lycii, Radix Rehmanniae Preparata, Radix Polygoni Multiflori, Fructus Ligustri Lucidi, Fructus Corni, Rhizoma Dioscoreae, Herba Ecliptae, Poria, Rhizoma Alismatis, Cortex Moutan and Oryza glutinosa are mixed;
B, adding 43-68%v/v ethanol 600-11000ml soak, and stir once in per 3 days, take out squeezing after 25 days, extract alcoholic solution;
C, alcoholic solution is packed in the hermetic container, 40 ℃ of constant temperature of temperature, distilling under reduced pressure, remove solvent ethanol wherein, last gained medical material active ingredient powder adds vitamin A 5-12 ten thousand units, admixes Mel 20-48g, routinely pharmaceutical methods make pill or routinely pharmaceutical methods make capsule or tablet.
6. according to the purposes of the described medicine of claim 1 as the medicine of preparation treatment alopecia and prevention alopecia.
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| CN102727761B (en) * | 2012-07-12 | 2013-11-27 | 郑州章光101生发科技有限公司 | Medicine for treating alopecia seborrheica and preventing hair drying and bifurcating and method for preparing medicine |
| CN104042877A (en) * | 2014-06-25 | 2014-09-17 | 汤华淑 | Traditional Chinese medicinal composition for treating alopecia |
| CN104906311B (en) * | 2015-06-12 | 2018-03-27 | 公安县中医医院 | A kind of traditional Chinese herbal decoction for treating diastolic heart failure |
| CN107126496A (en) * | 2017-05-16 | 2017-09-05 | 黄平县兴且民族民间中草医药科学发展有限责任公司 | It is a kind of to treat traditional Chinese medicine pill of white hair and preparation method thereof |
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| Title |
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| 魏跃钢.辩证治疗脂溢性脱发84例.南京中医药大学学报（自然科学版）18卷 4期.2002,18卷(4期),251. |
| 魏跃钢.辩证治疗脂溢性脱发84例.南京中医药大学学报(自然科学版)18卷 4期.2002,18卷(4期),251. * |
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