CN102000005A - Oral care solution - Google Patents
Oral care solution Download PDFInfo
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- CN102000005A CN102000005A CN2010105634594A CN201010563459A CN102000005A CN 102000005 A CN102000005 A CN 102000005A CN 2010105634594 A CN2010105634594 A CN 2010105634594A CN 201010563459 A CN201010563459 A CN 201010563459A CN 102000005 A CN102000005 A CN 102000005A
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Abstract
The invention relates to an oral care solution which comprises the following materials in percentage by weight: 1-20% of medicinal plant extract, 0.005-0.5% of sodium azulene sulfonate, 0.1-10% of active component, 0.01-0.5% of antibacterial agent, 1-15% of solubilizer, 0.01-5% of sweetening agent, 1-20% of thickening agent, 0.01-0.5% of perfume, 0.1-5% of ethanol, 13-90% of water and 0.001-10% of pH regulator. The oral care solution contains the medicinal plant extract of good mouthfeel acceptability and the active component protecting the mucosa, has natural and pure mouthfeel and is applicable to oral discomfort and daily oral care. The invention has the effects of cleaning oral cavity and teeth, relieving symptoms such as toothache, gum bleeding, oral ulcer, gingivitis, periodontitis, sore throat and the like and protecting oral health.
Description
Technical field
The present invention relates to a kind of oral nursing liquid.Particularly relate to a kind of suitable old man, child or suffer from that specific crowd that oral disease is not suitable for brushing teeth uses; can not use at daily health caring or oral cavity in good time; can effectively alleviate the multiple malaise symptoms in oral cavity, the oral nursing liquid of general protection tooth and oral health.
Background technology
In daily life, people still are accustomed to toothpaste cleaning teeth and oral cavity, but some specific crowds or specific occasion are always arranged, do not have conditioned disjunction not brush teeth for various reasons with toothpaste, as: with after the meal, see the client before, before and after the tooth treatment, or the old people of loss of tooth, the child that can not brush teeth etc.In this case, selecting collutory or oral nursing liquid to be in harmony ought be only again.
At present, the collutory of selling on the market has cleaning, the counteract oral malodour effect.Also have some oral nursing liquids to have the effect that eliminates dental plaque, and the effect of killing oral cavity bacterium.But, no matter be the collutory oral nursing liquid, and though the oral cavity is all had certain nursing role, most of user all is difficult to stand taste strange in its process of gargling, and especially the child is difficult to adapt to especially.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of oral cavity that both had been fit to not use also suitable daily mouth care, the oral nursing liquid of the health in protection oral cavity in good time.
The technical solution adopted in the present invention is: a kind of oral nursing liquid, comprise by weight: medicinal plant extract 1%-20%, sodium sulfonate 0.005-0.5% not, functional component 0.1%-10%, antibacterial 0.01%-0.5%, solubilizing agent 1-15%, sweeting agent 0.01%-5%, thickening agent 1-20%, essence 0.01%-0.5%, ethanol 0.1%-5%, water 13%-90%, pH value mediator agent 0.001%-10%.
Described medicinal plant extract is one or more in Flos Lonicerae, Radix Scrophulariae, Herba Lophatheri, Radix Gentianae Macrophyllae, Flos Chrysanthemi, green tea, Herba Pileae Scriptae, Herba Andrographis and the Radix Scutellariae.
Described functional component is one or more in fluoride, strontium chloride, strontium acetate, potassium chloride, potassium nitrate, the vitamin C.
Described antibacterial is a kind of in triclosan, hibitane, benzethonium chloride and the cetylpyridinium chloride.
Described solubilizing agent is one or both in Polyethylene Glycol and the tertiary sodium phosphate.
Described sweeting agent is one or more in sorbitol, glucide, stevioside, xylitol, the aspartame.
Described thickening agent is one or both in glycerol and the propylene glycol.
Described essence is the L-Mentholum.
Described solvent is one or both in the second alcohol and water.
Described pH value mediator agent comprises: one or more in sodium bicarbonate, tertiary sodium phosphate and sodium dihydrogen phosphate or the potassium.
Oral nursing liquid of the present invention, composition comprise the functional component of good medicinal plant extract of mouthfeel acceptance and protection mucosa, and mouthfeel is natural pure, both have been fit to the oral cavity and have not used in good time, also suitable daily mouth care.On effect, have: cleaning oral cavity and tooth, alleviate malaise symptoms such as toothache, gingival hemorrhage, oral ulcer, gingivitis, periodontitis, laryngopharynx swelling and pain, the health in protection oral cavity.The present invention has following characteristics:
1, sodium sulfonate is not allocated in the oral nursing liquid, can protect gingiva, throat and oral mucosa, makes the oral cavity more healthy.
2, the medicinal plant extract of choosing is allocated in the oral nursing liquid, except that keeping not the sodium sulfonate original flavor, made the product mouthfeel that adds Mentholum better, can also relieving sore-throat by clearing away heat, the auxiliary protection oral health.
3, develop and can be the solubilizing agent of one with not sodium sulfonate and medicinal plant extract and other composition are molten, oral nursing liquid can be made into the true solution of one, stable homogeneous strengthens commodity value.
The specific embodiment
Below in conjunction with embodiment and accompanying drawing oral nursing liquid of the present invention is made a detailed description.
Oral nursing liquid of the present invention is to comform multiple medicines with in the plant; through testing and relatively selecting nearly ten kinds except that having effects such as heat-clearing and toxic substances removing, pain easing and hemostasis, pharynx-clearing throat-benefiting; medicinal plants that also will not have bad abnormal smells from the patient; the extracts active ingredients of above-mentioned plant is come out, and it is formulated to be aided with functional component and the mouthfeel mediator agent of protecting the oral cavity.
Oral nursing liquid of the present invention comprises by weight: medicinal plant extract 1%-20%, sodium sulfonate 0.005-0.5% not, functional component 0.1%-10%, antibacterial 0.01%-0.5%, solubilizing agent 1-15%, sweeting agent 0.01%-5%, thickening agent 1-20%, essence 0.01%-0.5%, solvent 1%-90%, pH value mediator agent 0.001%-10%.
Wherein, described medicinal plant extract is one or more in Flos Lonicerae, Radix Scrophulariae, Herba Lophatheri, Radix Gentianae Macrophyllae, Flos Chrysanthemi, green tea, Herba Pileae Scriptae, Herba Andrographis and the Radix Scutellariae; Described functional component is one or more in fluoride, strontium chloride, strontium acetate, potassium chloride and the potassium nitrate; Described antibacterial is a kind of in triclosan, hibitane, benzethonium chloride and the cetylpyridinium chloride; Described solubilizing agent is one or both in Polyethylene Glycol and the tertiary sodium phosphate; Described sweeting agent is one or more in sorbitol, glucide, stevioside, xylitol, the aspartame; Described thickening agent is one or both in glycerol and the propylene glycol; Described essence is the L-Mentholum; Described solvent is one or both in the second alcohol and water; Described pH value mediator agent comprises: one or more in sodium bicarbonate, tertiary sodium phosphate and sodium dihydrogen phosphate or the potassium.
Embodiment one (100kg is an example with preparation)
Herba Lophatheri extract 0.5%
Flos Lonicerae extract 0.3%
Sodium sulfonate 0.005%
Sodium monofluorophosphate 0.1%
Potassium chloride 3%
PEG400 5%
Tertiary sodium phosphate 10%
Gluconate hibitane 0.01%
Sorbitol 20%
Propylene glycol 2%
Hibitane 0.01%
Sodium bicarbonate 0.02%
L-Mentholum 0.3%
Ethanol 3%
The purified water surplus
Embodiment two (100kg is an example with preparation)
Green tea extract 0.5%
Sodium sulfonate 0.01%
Sodium fluoride 0.1%
Sodium lauryl sulphate 2%
Sodium hydrogen phosphate 0.1%
Triclosan (DP-300) 0.01%
Stevioside 1%
Glycerol 5%
L-Mentholum 0.1%
Ethanol 0.5%
Sodium bicarbonate 0.01%
The purified water surplus
Embodiment three (100kg is an example with preparation)
Radix Scrophulariae extract 0.2%
Herba Andrographis extract 0.1%
Sodium sulfonate 0.01%
Sodium fluoride 0.1%
Dodecanol sodium sulfate 1.5%
Sodium hydrogen phosphate 0.1%
Cetylpyridinium chloride 0.01%
Saccharin sodium 0.05%
Glycerol 5%
L-Mentholum 0.1%
Ethanol 1%
Sodium bicarbonate 0.005%
VC 0.1％
Effect observation:
The crowd that choosing has a various oral cavities malaise symptoms is totally 260 examples, wherein based on volunteers' 85 examples of oral ulcer symptom; Volunteers' 86 examples that gingival hemorrhage and positive gingival swelling and pain are arranged at ordinary times with readme, with the laryngopharynx swelling and pain is volunteers' 89 examples of primary symptom shape, temporarily to be not suitable for brushing teeth and volunteers' 80 examples of halitosis arranged, these four groups of personnel used the application's patented product respectively 7 days, every day, observed result showed for several times:
Having in 85 examples of oral ulcer symptom has 78 routine feels pain obviously to alleviate, and ulcer surface is no longer rubescent, and effective percentage is 91.8%, and all the other personnel's feels pain have slightly and alleviate, and effect is not too obvious;
86 examples are had gingival hemorrhage and the symptom personnel that swell and ache, have 76 routine gingival hemorrhages that improvement is arranged, gingiva pain is improved clearly, and the sensation oral cavity is very comfortable in the use, and effective percentage is 88.4%, and all the other 10 examples are improved DeGrain;
To the user of service of 89 routine laryngopharynx swelling and pain, there are 86 routine pain obviously to alleviate, feel pharyngeal nice and cool comfortable, effective percentage 96.6%, other 6 examples feel to improve DeGrain;
Brush teeth and have the volunteers of halitosis to observe temporarily being not suitable for, comfortable with 80 routine panesthesia oral cavities, back, the cleaning oral cavity effect is obvious, and halitosis all has clear improvement, and effective percentage is 100%.
On the whole, the present invention to the oral ulcer, the gingival hemorrhage that occur at ordinary times, swell and ache, effect that laryngopharynx swelling and pain all has good relief of symptoms.Average effectiveness level is 92.3%; To oral cavity cleaning and to improve the halitosis effective percentage be 100%.
Claims (10)
1. an oral nursing liquid is characterized in that, comprises by weight: medicinal plant extract 1%-20%, sodium sulfonate 0.005-0.5% not, functional component 0.1%-10%, antibacterial 0.01%-0.5%, solubilizing agent 1-15%, sweeting agent 0.01%-5%, thickening agent 1-20%, essence 0.01%-0.5%, ethanol 0.1%-5%, water 13%-90%, pH value mediator agent 0.001%-10%.
2. oral nursing liquid according to claim 1 is characterized in that, described medicinal plant extract is one or more in Flos Lonicerae, Radix Scrophulariae, Herba Lophatheri, Radix Gentianae Macrophyllae, Flos Chrysanthemi, green tea, Herba Pileae Scriptae, Herba Andrographis and the Radix Scutellariae.
3. oral nursing liquid according to claim 1 is characterized in that, described functional component is one or more in fluoride, strontium chloride, strontium acetate, potassium chloride, potassium nitrate, the vitamin C.
4. oral nursing liquid according to claim 1 is characterized in that, described antibacterial is a kind of in triclosan, hibitane, benzethonium chloride and the cetylpyridinium chloride.
5. oral nursing liquid according to claim 1 is characterized in that, described solubilizing agent is one or both in Polyethylene Glycol and the tertiary sodium phosphate.
6. oral nursing liquid according to claim 1 is characterized in that, described sweeting agent is one or more in sorbitol, glucide, stevioside, xylitol, the aspartame.
7. oral nursing liquid according to claim 1 is characterized in that, described thickening agent is one or both in glycerol and the propylene glycol.
8. oral nursing liquid according to claim 1 is characterized in that, described essence is the L-Mentholum.
9. oral nursing liquid according to claim 1 is characterized in that, described solvent is one or both in the second alcohol and water.
10. oral nursing liquid according to claim 1 is characterized in that, described pH value mediator agent comprises: one or more in sodium bicarbonate, tertiary sodium phosphate and sodium dihydrogen phosphate or the potassium.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010563459 CN102000005B (en) | 2010-11-27 | 2010-11-27 | Oral care solution |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010563459 CN102000005B (en) | 2010-11-27 | 2010-11-27 | Oral care solution |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102000005A true CN102000005A (en) | 2011-04-06 |
| CN102000005B CN102000005B (en) | 2013-03-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201010563459 Active CN102000005B (en) | 2010-11-27 | 2010-11-27 | Oral care solution |
Country Status (1)
| Country | Link |
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| CN (1) | CN102000005B (en) |
Cited By (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526280A (en) * | 2012-02-21 | 2012-07-04 | 张超 | Chinese medicinal composition for treating dental ulcer |
| CN102793836A (en) * | 2012-08-31 | 2012-11-28 | 褚明来 | Uncertain toothache fumigation medicament and preparation method and application method thereof |
| CN104042780A (en) * | 2014-06-20 | 2014-09-17 | 王玉果 | Oral cavity care solution |
| CN105213353A (en) * | 2015-10-16 | 2016-01-06 | 天津市顶硕科贸有限公司 | Compound oral membrane containing Sodium Azulenesulfonate and preparation method |
| CN105535591A (en) * | 2015-12-28 | 2016-05-04 | 张敏 | Oral care solution and preparation method for same |
| CN105963190A (en) * | 2016-06-21 | 2016-09-28 | 江苏奇力康皮肤药业有限公司 | Antisepsis and anti-inflammation mouth wash |
| CN106038414A (en) * | 2016-07-11 | 2016-10-26 | 周晗生 | Manufacturing method of portable mouth care product |
| CN106074274A (en) * | 2016-07-11 | 2016-11-09 | 周晗生 | Oral care substance |
| CN106074277A (en) * | 2016-07-11 | 2016-11-09 | 周晗生 | Portable oral care thing |
| CN106074275A (en) * | 2016-07-11 | 2016-11-09 | 周晗生 | The manufacture method of graininess oral care composition |
| CN106074341A (en) * | 2016-07-11 | 2016-11-09 | 周晗生 | Portable oral care liquid |
| CN106491390A (en) * | 2016-12-13 | 2017-03-15 | 美晨集团股份有限公司 | A kind of persistently refrigerant antibacterial oral cavity cleaning and nursing liquid and preparation method thereof |
| CN106729650A (en) * | 2017-03-03 | 2017-05-31 | 江苏所罗门兄弟医学科技有限公司 | A kind of oral cavity gargle for tumor patient |
| CN106974847A (en) * | 2017-04-17 | 2017-07-25 | 江苏恩为众心生物医药有限公司 | Compound sodium azulenesulfonate gargle production technology |
| CN107007539A (en) * | 2017-04-17 | 2017-08-04 | 江苏恩为众心生物医药有限公司 | Probiotics gargle production technology |
| CN107007502A (en) * | 2017-04-18 | 2017-08-04 | 新疆中草堂医药科技有限公司 | The oral care composition of noresidue sense |
| CN107789518A (en) * | 2017-10-25 | 2018-03-13 | 林振 | A kind of oral nursing liquid of oral mucositis caused by Prophylactic chemotherapy |
| CN107875085A (en) * | 2017-11-05 | 2018-04-06 | 长沙秋点兵信息科技有限公司 | Oral cavity nursing agent and preparation method thereof |
| CN107951733A (en) * | 2017-11-16 | 2018-04-24 | 江苏大学 | The preparation and its application of Azulene sodium sulfonate and Cetylpyridinium Chloride compound mouthwash |
| CN108113943A (en) * | 2018-02-05 | 2018-06-05 | 苏州工业园区方津口腔诊所有限公司 | A kind of Pediatric Oral Emergency care method |
| CN108853487A (en) * | 2018-07-25 | 2018-11-23 | 长沙浩然医疗科技有限公司 | A kind of oral nursing liquid and preparation method thereof for treating canker sore |
| CN109549920A (en) * | 2017-09-26 | 2019-04-02 | 钻石制药株式会社 | Aqueous formulation |
| CN110251664A (en) * | 2019-07-05 | 2019-09-20 | 广州康云生物科技有限公司 | A kind of oral nursing liquid containing lysozyme and plant extracts |
| CN112618451A (en) * | 2020-11-24 | 2021-04-09 | 云南云药医药研究有限公司 | Composition containing natural antibacterial ingredients and application |
| CN113181102A (en) * | 2021-03-09 | 2021-07-30 | 北京圣永制药有限公司 | Mouthwash with functions of moistening oral cavity and refreshing breath and preparation method thereof |
| CN113230165A (en) * | 2021-04-02 | 2021-08-10 | 北京圣永制药有限公司 | A collutory containing marrubium vulgare extract with antiinflammatory and antibacterial effects |
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| CN113398205A (en) * | 2021-07-01 | 2021-09-17 | 李霞 | Anti-cancer oral care solution and preparation method thereof |
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| CN1842314A (en) * | 2003-08-27 | 2006-10-04 | 株式会社哈尼克斯 | Composition for application to tooth |
| CN101048149A (en) * | 2004-10-28 | 2007-10-03 | 兴和株式会社 | Solid pharmaceutical preparation dissolved in oral cavity |
| CN101062005A (en) * | 2007-05-22 | 2007-10-31 | 天津市顶硕科贸有限公司 | Medical toothpaste including sodium azulene sulfonate |
Cited By (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526280A (en) * | 2012-02-21 | 2012-07-04 | 张超 | Chinese medicinal composition for treating dental ulcer |
| CN102793836A (en) * | 2012-08-31 | 2012-11-28 | 褚明来 | Uncertain toothache fumigation medicament and preparation method and application method thereof |
| CN104042780A (en) * | 2014-06-20 | 2014-09-17 | 王玉果 | Oral cavity care solution |
| CN105213353B (en) * | 2015-10-16 | 2018-05-22 | 天津顶硕药业股份有限公司 | Compound oral film and preparation method containing sodium azulenesulfonate |
| CN105213353A (en) * | 2015-10-16 | 2016-01-06 | 天津市顶硕科贸有限公司 | Compound oral membrane containing Sodium Azulenesulfonate and preparation method |
| CN105535591A (en) * | 2015-12-28 | 2016-05-04 | 张敏 | Oral care solution and preparation method for same |
| CN105963190A (en) * | 2016-06-21 | 2016-09-28 | 江苏奇力康皮肤药业有限公司 | Antisepsis and anti-inflammation mouth wash |
| WO2017219835A1 (en) * | 2016-06-21 | 2017-12-28 | 江苏奇力康皮肤药业有限公司 | Anti-bacterial and anti-inflammatory mouthwash |
| CN106038414A (en) * | 2016-07-11 | 2016-10-26 | 周晗生 | Manufacturing method of portable mouth care product |
| CN106074275A (en) * | 2016-07-11 | 2016-11-09 | 周晗生 | The manufacture method of graininess oral care composition |
| CN106074341A (en) * | 2016-07-11 | 2016-11-09 | 周晗生 | Portable oral care liquid |
| CN106074277A (en) * | 2016-07-11 | 2016-11-09 | 周晗生 | Portable oral care thing |
| CN106074274A (en) * | 2016-07-11 | 2016-11-09 | 周晗生 | Oral care substance |
| CN106491390A (en) * | 2016-12-13 | 2017-03-15 | 美晨集团股份有限公司 | A kind of persistently refrigerant antibacterial oral cavity cleaning and nursing liquid and preparation method thereof |
| CN106729650A (en) * | 2017-03-03 | 2017-05-31 | 江苏所罗门兄弟医学科技有限公司 | A kind of oral cavity gargle for tumor patient |
| CN107007539A (en) * | 2017-04-17 | 2017-08-04 | 江苏恩为众心生物医药有限公司 | Probiotics gargle production technology |
| CN106974847A (en) * | 2017-04-17 | 2017-07-25 | 江苏恩为众心生物医药有限公司 | Compound sodium azulenesulfonate gargle production technology |
| CN107007502A (en) * | 2017-04-18 | 2017-08-04 | 新疆中草堂医药科技有限公司 | The oral care composition of noresidue sense |
| CN109549920A (en) * | 2017-09-26 | 2019-04-02 | 钻石制药株式会社 | Aqueous formulation |
| CN109549920B (en) * | 2017-09-26 | 2022-02-18 | 钻石制药株式会社 | Aqueous preparation |
| CN107789518A (en) * | 2017-10-25 | 2018-03-13 | 林振 | A kind of oral nursing liquid of oral mucositis caused by Prophylactic chemotherapy |
| CN107875085A (en) * | 2017-11-05 | 2018-04-06 | 长沙秋点兵信息科技有限公司 | Oral cavity nursing agent and preparation method thereof |
| CN107951733A (en) * | 2017-11-16 | 2018-04-24 | 江苏大学 | The preparation and its application of Azulene sodium sulfonate and Cetylpyridinium Chloride compound mouthwash |
| CN108113943B (en) * | 2018-02-05 | 2021-06-08 | 苏州工业园区方津口腔诊所有限公司 | Oral care method for children |
| CN108113943A (en) * | 2018-02-05 | 2018-06-05 | 苏州工业园区方津口腔诊所有限公司 | A kind of Pediatric Oral Emergency care method |
| CN108853487A (en) * | 2018-07-25 | 2018-11-23 | 长沙浩然医疗科技有限公司 | A kind of oral nursing liquid and preparation method thereof for treating canker sore |
| CN110251664A (en) * | 2019-07-05 | 2019-09-20 | 广州康云生物科技有限公司 | A kind of oral nursing liquid containing lysozyme and plant extracts |
| CN112618451A (en) * | 2020-11-24 | 2021-04-09 | 云南云药医药研究有限公司 | Composition containing natural antibacterial ingredients and application |
| CN113181102A (en) * | 2021-03-09 | 2021-07-30 | 北京圣永制药有限公司 | Mouthwash with functions of moistening oral cavity and refreshing breath and preparation method thereof |
| CN113230165A (en) * | 2021-04-02 | 2021-08-10 | 北京圣永制药有限公司 | A collutory containing marrubium vulgare extract with antiinflammatory and antibacterial effects |
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Effective date of registration: 20160222 Address after: 300308, B205, building 8, airport business park, 80 Ring Road North, Tianjin Airport Economic Zone Patentee after: Tianjin top pharmaceutical technology Co., Ltd. Address before: 300110 Tianjin city Xiqing District Zhangjiawo Industrial Zone Fengze Road No. 6 Patentee before: Tianjin Jing Shuo Science and Trade Co., Ltd. |
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| C56 | Change in the name or address of the patentee | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 300308, B205, building 8, airport business park, 80 Ring Road North, Tianjin Airport Economic Zone Patentee after: Tianjin top pharmaceutical Limited by Share Ltd Address before: 300308, B205, building 8, airport business park, 80 Ring Road North, Tianjin Airport Economic Zone Patentee before: Tianjin top pharmaceutical technology Co., Ltd. |
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| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Oral care solution Effective date of registration: 20210318 Granted publication date: 20130327 Pledgee: Business Department of Bank of Tianjin Co.,Ltd. Pledgor: Tianjin top pharmaceutical Limited by Share Ltd. Registration number: Y2021120000008 |
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| PE01 | Entry into force of the registration of the contract for pledge of patent right |