CN106491390A - A kind of persistently refrigerant antibacterial oral cavity cleaning and nursing liquid and preparation method thereof - Google Patents
A kind of persistently refrigerant antibacterial oral cavity cleaning and nursing liquid and preparation method thereof Download PDFInfo
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- CN106491390A CN106491390A CN201611146581.5A CN201611146581A CN106491390A CN 106491390 A CN106491390 A CN 106491390A CN 201611146581 A CN201611146581 A CN 201611146581A CN 106491390 A CN106491390 A CN 106491390A
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- oral cavity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
- A61K8/8182—Copolymers of vinyl-pyrrolidones. Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
Abstract
The invention discloses a kind of persistently refrigerant antibacterial oral cavity cleaning and nursing liquid, the preparing raw material of the oral cavity cleaning and nursing liquid includes：NMF, foaming agent, solubilizer, flavoring essence, water and persistently refrigerant antibacterial composition；The composition includes following components：Freshener and bacteriostatic agent and the high molecular polymer that can be complexed with the bacteriostatic agent.The invention also discloses the preparation method of persistently refrigerant antibacterial oral cavity cleaning and nursing liquid.After the oral cavity cleaning and nursing liquid use of the present invention, remain to make freshener and bacteriostatic agent as high molecular polymer is sticked at oral mucosa, and form film, reach persistently refrigerant and antibacterial effect.
Description
Technical field
The invention belongs to field of oral care, more particularly to a kind of persistently refrigerant antibacterial oral cavity cleaning and nursing liquid and its system
Preparation Method.
Background technology
Halitosis referred to from oral cavity or other cavitys full of air such as nose, nasal sinus, pharynx, the foul smell peculiar smell for being given out,
It affects the normal contacts of people and exchanges, and affects the social image and mental health of itself.One recent investigation shows
Show, the incidence of disease of the halitosis in Chinese population has reached 27.5%, its pathogenic factor belong to the patient of oral cavity intrinsic factor account for 80～
90%.Mouth source property halitosis mainly decomposes the materials such as sulfur-containing amino acid, peptide and protein by oral cavity bacterium is corrupt, generation
Caused by volatile sulfur compounds and the aliphatic acid with peculiar smell.Therefore, for mouth source property halitosis can pass through to remove to produce halitosis
Pathogenic microorganism and its toxin for producing and rapid directly remove in oral cavity smelly class chemical compound gas to suppress halitosis, pure and fresh
Implication.
At present, numerous studies have been done in terms of fresh breath, suppression halitosis.For example, Application No. " CN931060702 "
Patent of invention disclose the refrigerant effect of collaboration of the compositions such as menthol, amide of mint, menthone glycerol ketals and its simple
Application.For the patent of invention of " CN1124126C ", Authorization Notice No. elaborates that menthol and its combination application of derivative can be obtained
The cooling effect of collaboration.Application publication number refer to a kind of coolant compositions by poly- paddy for the patent of invention of " CN0577837A "
Propylhomoserin and oil-soluble freshener composition, in the presence of polyglutamic acid, the release time of freshener is extended.Application publication number
Patent of invention for " CN104257544A " refer to remove halitosis using cyclodextrin, Gantrez AN-119, Tea Polyphenols etc..Authorize
Notification number refer to polyvinylpyrrolidone, polypropylene copolymer etc. with double chlorobenzenes pair for the patent of invention of " CN102512337B "
Guanidine hexane, dodecyl benzyl dimethyl ammonium chloride, cetylpyridinium chloride are used, and extend the antibacterial time.
In techniques disclosed above, when the utilization of freshener is related to, have studied freshener and be applied in combination and can play collaboration
Effect, strengthens refrigerant degree, but has been short of in refrigerant persistence, also has the research for extending persistence using polyglutamic acid,
But based on cosmetics of everyday use, the price of polyglutamic acid is higher, needs unsuitable for basic commodity industrialization；It is related to bacteriostatic agent
Utilization when, have the research are used in conjunction by high molecular polymer and bacteriostatic agent, but above only to chlorhexidine, dodecyl dimethyl benzyl
The superpower effect bacteriostatic agent such as ammonium chloride and plant extracts Tea Polyphenols are studied, the research for proposing bacteriostatic agent to the present invention
It has been short of.
Content of the invention
On the one hand, it is an object of the invention to overcoming the weak point of prior art presence and providing a kind of persistently refrigerant
There is the refrigerant degree of low cost, product and fungistatic effect to protect for antibacterial oral cavity cleaning and nursing liquid, the oral cavity cleaning and nursing liquid of the present invention
Lasting advantage.
The technical solution used in the present invention is：A kind of persistently refrigerant antibacterial oral cavity cleaning and nursing liquid, the oral cleaning
The preparing raw material of conditioning liquid includes：NMF, foaming agent, solubilizer, flavoring essence, water and persistently refrigerant antibacterial combination
Thing；
The composition includes following components：Freshener and bacteriostatic agent and the height that can be complexed with the bacteriostatic agent
Molecularly Imprinted Polymer.
As the further improvement to above-mentioned technical proposal, count by weight, the consumption of each component in the composition
For：0.1～20 part of 0.2～4 part of freshener, 0.01～4 part of bacteriostatic agent and high molecular polymer.
The freshener is selected from peppermint derivative, used as the further improvement to above-mentioned technical proposal, the freshener
Including menthol (2- isopropyl -5- methyl cyclohexanols), menthyl lactate (2 hydroxy propanoic acid -5- methyl -2- isopropyl hexamethylenes
Ester), amide of mint (N- ethyls-to menthyl -3- formamides), menthyl acetate (acetic acid -5- methyl -2- isopropyl hexamethylenes
Ester), menthone glycerol ketals (6- isopropyl -9- methyl isophthalic acids, 4- dioxy spiral shells (4,5)-decane -2- methyl alcohol), WS-23 (N, 2,3-
Trimethyl -2- butanamides), in WS-5 (N- (ethoxycarbonylmethyl group)-to alkane -3- formamides) and their derivative
At least one.
Used as the further improvement to above-mentioned technical proposal, the bacteriostatic agent includes o- cymene -5- alcohol, nano-silver ionic
Ag+, at least one in cetylpyridinium chloride and Dialkyl dimethyl ammonium chloride class (such as Quaternium 24).
Used as the further improvement to above-mentioned technical proposal, the bacteriostatic agent includes o- cymene -5- alcohol, nano-silver ionic
Ag+, in cetylpyridinium chloride and Dialkyl dimethyl ammonium chloride class at least two.
Used as the further improvement to above-mentioned technical proposal, the high molecular polymer includes acrylic copolymer (such as
Polyacrylate) and vinyl-based copolymer (such as polyvinylpyrrolidone and methyl vinyl ether-maleic acid glycosides copolymer).
Used as the further improvement to above-mentioned technical proposal, the high molecular polymer is polyvinylpyrrolidone and methyl
The mixture of vinylether-maleic acid glycosides copolymer, wherein, polyvinylpyrrolidone and methyl vinyl ether-maleic acid glycosides are altogether
The weight ratio of polymers is 1～100：1～100.
Used as the further improvement to above-mentioned technical proposal, densimeter by weight percentage, comprising following preparing raw material：Protect
Humectant 4～50%, foaming agent 1～3%, solubilizer 0.1～3%, flavoring essence 0.2～2%, ethanol 0～40%, persistently refrigerant
Antibacterial composition 0.31～28%, balance of water.
Used as the further improvement to above-mentioned technical proposal, the preparing raw material is also comprising sweetener and pigment.
As the further improvement to above-mentioned technical proposal, the NMF include sorbierite, polyethylene glycol, propane diols,
At least one in glycerine.
Used as the further improvement to above-mentioned technical proposal, the solubilizer is included in tween -8, rilanit special extremely
Few one kind.
Used as the further improvement to above-mentioned technical proposal, the foaming agent includes lauryl sodium sulfate, moon silicic acid flesh
At least one in propylhomoserin sodium, Cocoamidopropyl betaine, APG.
On the other hand, present invention also offers the preparation side of above-described persistently refrigerant antibacterial oral cavity cleaning and nursing liquid
Method, it is characterised in that：Comprise the following steps：The NMF, high molecular polymer, foaming agent, water are well mixed, A groups are obtained
Component；The solubilizer, bacteriostatic agent, essence, ethanol, freshener are well mixed, B group components are obtained；By A groups component and B group groups
Divide and be well mixed, obtain final product the oral cavity cleaning and nursing liquid.
Relative to prior art, beneficial effects of the present invention are：
1) composition used in oral cavity cleaning and nursing liquid of the invention, on the basis of freshener is applied in combination, in conjunction with
Industry-wide and more cheap high molecular polymer is applied, refrigerant effect can be extended on the basis of the cool degree of freshener is strengthened
The time of fruit, adapt to Market Consumer demand；
2) present invention is studied with reference to high molecular polymer application to target bacteriostatic agent, good in high molecular polymer
Cohesive and film forming promotion under, extend the bacteriostasis time of bacteriostatic agent, in conjunction with by compound bacteriostatic agent, serve
Preferably fungistatic effect, has preferably lifting in the economic profit of enterprise and the safety in utilization of consumer.
3) after freshener and bacteriostatic agent are fully mixed in high molecular polymer and make oral cavity cleaning and nursing liquid, bacteriostatic agent meeting
It is complexed with polymer composite, when using oral cavity cleaning and nursing liquid, as high molecular polymer has good bonding
Property and film forming, using after oral cavity cleaning and nursing liquid, remain to make freshener and bacteriostatic agent as high molecular polymer is sticked to
At oral mucosa, and film is formed, reach persistently refrigerant and antibacterial effect.
Specific embodiment
The embodiment provides a kind of persistently refrigerant antibacterial oral cavity cleaning and nursing liquid, the oral cavity cleaning and nursing
The preparing raw material of liquid includes：NMF, foaming agent, solubilizer, flavoring essence, water and persistently refrigerant antibacterial composition；
The composition includes following components：Freshener and bacteriostatic agent and the height that can be complexed with the bacteriostatic agent
Molecularly Imprinted Polymer, wherein, is counted by weight, and in the composition, the consumption of each component is：0.2～4 part of freshener, bacteriostatic agent
0.01～4 part and 0.1～20 part of high molecular polymer.
Wherein, densimeter by weight percentage, the persistently refrigerant antibacterial oral cavity cleaning and nursing liquid include following preparation
Raw material：NMF 4～50%, foaming agent 1～3%, solubilizer 0.1～3%, flavoring essence 0.2～2%, ethanol 0～40%,
Persistently refrigerant antibacterial composition 0.31～28%, balance of water.
The freshener can be peppermint derivative, it is preferable that the freshener includes menthol (2- isopropyl -5- methyl
Cyclohexanol), menthyl lactate (2 hydroxy propanoic acid -5- methyl -2- isopropyl cyclohexyls), amide of mint (N- ethyls-to peppermint
Base -3- formamides), menthyl acetate (acetic acid -5- methyl -2- isopropyl cyclohexyls), menthone glycerol ketals (6- isopropyls -
9- methyl isophthalic acids, 4- dioxy spiral shells (4,5)-decane -2- methyl alcohol), WS-23 (N, 2,3- trimethyl -2- butanamides), WS-5
At least one in (N- (ethoxycarbonylmethyl group)-to alkane -3- formamides) and their derivative.In order to improve cooling effect,
Increase refrigerant degree, it is preferable that the freshener is selected from following combination：(1) mixture of menthol and amide of mint is wherein, thin
The weight ratio of lotus alcohol and amide of mint is 1～20：1～20；(2) mixture of menthol and menthyl lactate, wherein, menthol
Weight ratio with menthyl lactate is 1～20：1～20.
The bacteriostatic agent includes o- cymene -5- alcohol, nano-silver ionic Ag+, cetylpyridinium chloride and double alkyl two
At least one in ammonio methacrylate class (such as Quaternium 24).Preferably, the bacteriostatic agent include o- cymenes-
5- alcohol, nano-silver ionic Ag+, in cetylpyridinium chloride and Dialkyl dimethyl ammonium chloride class at least two.Through research
It was found that, after the reasonable compounding use of two or more bacteriostatic agents, in the presence of high molecular polymer, have more preferably more longlasting antibacterial
Effect.
Used as the further improvement to above-mentioned technical proposal, the high molecular polymer includes acrylic copolymer (such as
Polyacrylate) and vinyl-based copolymer (such as polyvinylpyrrolidone and methyl vinyl ether-maleic acid glycosides copolymer).Excellent
Selection of land, the high molecular polymer are the mixture of polyvinylpyrrolidone and methyl vinyl ether-maleic acid glycosides copolymer, its
In, the weight ratio of polyvinylpyrrolidone and methyl vinyl ether-maleic acid glycosides copolymer is 1～100：1～100.Test card
Bright polyvinylpyrrolidone and methyl vinyl ether-maleic acid glycosides polymer combination using effect are substantially better than both and are used alone
Effect.
In a specific embodiment, the preparing raw material is also comprising sweetener and pigment.Preferably, the sweetener bag
Include at least one in saccharin sodium, stevioside, Sucralose.
The NMF includes at least one in sorbierite, polyethylene glycol, propane diols, glycerine.Preferably, the moisturizing
Agent is sorbierite, the mixture of PEG-8, and sorbierite is 2-30 with the weight ratio of PEG-8：2-20.
The solubilizer includes at least one in tween -8, rilanit special.
The foaming agent includes lauryl sodium sulfate, moon silicic acid sodium sarcosinate, Cocoamidopropyl betaine, alkyl sugar
At least one in glycosides.
In one preferred embodiment, a kind of persistently refrigerant antibacterial oral cavity cleaning and nursing liquid, by weight percentage
Densimeter, the preparing raw material of the oral cavity cleaning and nursing liquid include：
Sorbierite 2%-30%
PEG-8 2%-20%
Lauryl sodium sulfate 0.1%-2%
Sodium lauroyl sarcosine 0.001%-1%
Saccharin sodium 0.01%-0.3%
Sucralose 0.01%-0.3%
Polyacrylate 0.1%-10%
Pigment 0.001%-1%
Tween-80 0.1%-3%
O- cymene -5- alcohol 0.01%-0.1%
Menthol 0.1%-2%
Menthyl lactate 0.1%-2%
Essence 0.2%-2%
Ethanol 0%-40%
Deionized water surplus.
Another preferred embodiment in, a kind of persistently refrigerant antibacterial oral cavity cleaning and nursing liquid, by weight percentage
Specific concentration meter, the preparing raw material of the oral cavity cleaning and nursing liquid include：
Sorbierite 2%-30%
PEG-8 2%-20%
Lauryl sodium sulfate 0.1%-2%
Sodium lauroyl sarcosine 0.001%-1%
Saccharin sodium 0.01%-0.3%
Sucralose 0.01%-0.3%
Polyvinylpyrrolidone 0.1%-10%
Methyl vinyl ether-maleic acid glycosides copolymer 0.1%-10%
Pigment 0.001%-1%
Rilanit special 0.1%-3%
Ag+0.1%-2%
Menthol 0.1%-2%
Amide of mint 0.1%-2%
Essence 0.2%-2%
Ethanol 0%-40%
Deionized water surplus.
Another preferred embodiment in, a kind of persistently refrigerant antibacterial oral cavity cleaning and nursing liquid, by weight percentage
Specific concentration meter, the preparing raw material of the oral cavity cleaning and nursing liquid include：
Sorbierite 2%-30%
PEG-8 2%-20%
Lauryl sodium sulfate 0.1%-2%
Sodium lauroyl sarcosine 0.001%-1%
Saccharin sodium 0.01%-0.3%
Sucralose 0.01%-0.3%
Polyvinylpyrrolidone 0.1%-10%
Methyl vinyl ether-maleic acid glycosides copolymer 0.1%-10%
Pigment 0.001%-1%
Rilanit special 0.1%-3%
Cetylpyridinium chloride 0.1%-2%
Ag+0.1%-2%
Menthol 0.1%-2%
Amide of mint 0.1%-2%
Essence 0.2%-2%
Ethanol 0%-40%
Deionized water surplus.
Embodiments of the invention additionally provide the preparation method of described lasting refrigerant antibacterial oral cavity cleaning and nursing liquid, its
It is characterised by：Comprise the following steps：By the NMF, high molecular polymer, foaming agent, sweetener, water, pigment mixing 10-
50min, obtains A group components；By the solubilizer, bacteriostatic agent, essence, ethanol, freshener mixing 10-50min, B group components are obtained；Will
A groups component mixes 10-50min with B group components, obtains final product the oral cavity cleaning and nursing liquid.
Above-described freshener and bacteriostatic agent are fully mixed after making oral cavity cleaning and nursing liquid in high molecular polymer,
Bacteriostatic agent can be complexed with polymer composite, using oral cavity cleaning and nursing liquid when, due to high molecular polymer have good
Good cohesive and film forming, after using oral cavity cleaning and nursing liquid, remain to make freshener and bacteriostatic agent with high molecular polymerization
Thing is sticked at oral mucosa, and forms film, reaches persistently refrigerant and antibacterial effect.
For better illustrating the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
Embodiment 1
A kind of persistently refrigerant antibacterial oral cavity cleaning and nursing liquid, by weight percentage densimeter, the oral cavity cleaning and nursing
The preparing raw material of liquid includes：
Sorbierite 2%
PEG-8 20%
Lauryl sodium sulfate 1%
Sodium lauroyl sarcosine 1%
Saccharin sodium 0.01%
Sucralose 0.3%
Polyacrylate 10%
Pigment 0.001%
Tween-80 3%
O- cymene -5- alcohol 0.1%
Menthol 2%
Menthyl lactate 0.1%
Essence 0.2%
Ethanol 40%
Deionized water surplus.
The preparation method of the lasting refrigerant antibacterial oral cavity cleaning and nursing liquid of the present embodiment, comprises the following steps：Including with
Lower step：By the NMF, high molecular polymer, foaming agent, sweetener, water, pigment mixing 10min, A group components are obtained；Will
The solubilizer, bacteriostatic agent, essence, ethanol, freshener mixing 10min, obtain B group components；A groups component is mixed with B group components
30min, obtains final product the oral cavity cleaning and nursing liquid.
Embodiment 2
A kind of persistently refrigerant antibacterial oral cavity cleaning and nursing liquid, by weight percentage densimeter, the oral cavity cleaning and nursing
The preparing raw material of liquid includes：
Sorbierite 30%
PEG-8 2%
Lauryl sodium sulfate 2%
Sodium lauroyl sarcosine 0.001%
Saccharin sodium 0.3%
Sucralose 0.01%
Polyacrylate 0.1%
Pigment 1%
Tween-80 0.1%
O- cymene -5- alcohol 0.05%
Menthol 0.1%
Menthyl lactate 2%
Essence 2%
Ethanol 10%
Deionized water surplus.
The preparation method of the lasting refrigerant antibacterial oral cavity cleaning and nursing liquid of the present embodiment, comprises the following steps：Including with
Lower step：By the NMF, high molecular polymer, foaming agent, sweetener, water, pigment mixing 50min, A group components are obtained；Will
The solubilizer, bacteriostatic agent, essence, ethanol, freshener mixing 50min, obtain B group components；A groups component is mixed with B group components
10min, obtains final product the oral cavity cleaning and nursing liquid.
Embodiment 3
A kind of persistently refrigerant antibacterial oral cavity cleaning and nursing liquid, by weight percentage densimeter, the oral cavity cleaning and nursing
The preparing raw material of liquid includes：
Sorbierite 15%
PEG-8 15%
Lauryl sodium sulfate 0.13%
Sodium lauroyl sarcosine 0.5%
Saccharin sodium 0.1%
Sucralose 0. 1%
Polyacrylate 5%
Pigment 0.5%
Tween-80 2%
O- cymene -5- alcohol 0.01%
Menthol 1%
Menthyl lactate 1%
Essence 1%
Ethanol 20%
Deionized water surplus.
The preparation method of the lasting refrigerant antibacterial oral cavity cleaning and nursing liquid of the present embodiment, comprises the following steps：Including with
Lower step：By the NMF, high molecular polymer, foaming agent, sweetener, water, pigment mixing 30min, A group components are obtained；Will
The solubilizer, bacteriostatic agent, essence, ethanol, freshener mixing 30min, obtain B group components；A groups component is mixed with B group components
30min, obtains final product the oral cavity cleaning and nursing liquid.
Embodiment 4
A kind of persistently refrigerant antibacterial oral cavity cleaning and nursing liquid, by weight percentage densimeter, the oral cavity cleaning and nursing
The preparing raw material of liquid includes：
Sorbierite 2%
PEG-8 20%
Lauryl sodium sulfate 0.1%
Sodium lauroyl sarcosine 1%
Saccharin sodium 0.01%
Sucralose 0.3%
Polyvinylpyrrolidone 10%
Methyl vinyl ether-maleic acid glycosides copolymer 5%
Pigment 0.001%
Rilanit special 3%
Ag+1%
Menthol 0.1%
Amide of mint 2%
Essence 0.2%
Ethanol 20%
Deionized water surplus.
The preparation method of the lasting refrigerant antibacterial oral cavity cleaning and nursing liquid of the present embodiment is with embodiment 3.
Embodiment 5
A kind of persistently refrigerant antibacterial oral cavity cleaning and nursing liquid, by weight percentage densimeter, the oral cavity cleaning and nursing
The preparing raw material of liquid includes：
Sorbierite 30%
PEG-8 2%
Lauryl sodium sulfate 2%
Sodium lauroyl sarcosine 0.01%
Saccharin sodium 0.3%
Sucralose 0.01%
Polyvinylpyrrolidone 2%
Methyl vinyl ether-maleic acid glycosides copolymer 1 0%
Pigment 1%
Rilanit special 2%
Ag+2%
Menthol 2%
Amide of mint 0.1%
Essence 2%
Ethanol 40%
Deionized water surplus.
The preparation method of the lasting refrigerant antibacterial oral cavity cleaning and nursing liquid of the present embodiment is with embodiment 3.
Embodiment 6
A kind of persistently refrigerant antibacterial oral cavity cleaning and nursing liquid, by weight percentage densimeter, the oral cavity cleaning and nursing
The preparing raw material of liquid includes：
Sorbierite 15%
PEG-8 15%
Lauryl sodium sulfate 1%
Sodium lauroyl sarcosine 0.5%
Saccharin sodium 0.1%
Sucralose 0. 1%
Polyvinylpyrrolidone 5%
Methyl vinyl ether-maleic acid glycosides copolymer 5%
Pigment 0.5%
Rilanit special 1%
Ag+ 0.1%
Menthol 1%
Amide of mint 1%
Essence 1%
Ethanol 10%
Deionized water surplus.
The preparation method of the lasting refrigerant antibacterial oral cavity cleaning and nursing liquid of the present embodiment is with embodiment 3.
Embodiment 7
The preparing raw material of the lasting refrigerant antibacterial oral cavity cleaning and nursing liquid of the present embodiment is chlorination 16 except bacteriostatic agent
Alkyl pyridine, and outside its consumption is 1%, remaining is with embodiment 4.
The preparation method of the lasting refrigerant antibacterial oral cavity cleaning and nursing liquid of the present embodiment is with embodiment 4.
Embodiment 8
The preparing raw material of the lasting refrigerant antibacterial oral cavity cleaning and nursing liquid of the present embodiment is chlorination 16 except bacteriostatic agent
Alkyl pyridine, and outside its consumption is 2%, remaining is with embodiment 5.
The preparation method of the lasting refrigerant antibacterial oral cavity cleaning and nursing liquid of the present embodiment is with embodiment 5.
Embodiment 9
The preparing raw material of the lasting refrigerant antibacterial oral cavity cleaning and nursing liquid of the present embodiment is chlorination 16 except bacteriostatic agent
Alkyl pyridine, and outside its consumption is 0.1%, remaining is with embodiment 6.
The preparation method of the lasting refrigerant antibacterial oral cavity cleaning and nursing liquid of the present embodiment is with embodiment 6.
Embodiment 10
The preparing raw material of the lasting refrigerant antibacterial oral cavity cleaning and nursing liquid of the present embodiment is chlorination 16 except bacteriostatic agent
Alkyl pyridine and Ag+Mixture, cetylpyridinium chloride and Ag+Consumption is identical and both total consumptions are 1% (weight
Percentage) outside, remaining is with embodiment 4.
The preparation method of the lasting refrigerant antibacterial oral cavity cleaning and nursing liquid of the present embodiment is with embodiment 4.
Embodiment 11
The preparing raw material of the lasting refrigerant antibacterial oral cavity cleaning and nursing liquid of the present embodiment is chlorination 16 except bacteriostatic agent
Alkyl pyridine and Ag+Mixture, cetylpyridinium chloride and Ag+Weight ratio be 1:2 and both total consumptions be 2% (weight
Amount percentage) outside, remaining is with embodiment 5.
The preparation method of the lasting refrigerant antibacterial oral cavity cleaning and nursing liquid of the present embodiment is with embodiment 5.
Embodiment 12
The preparing raw material of the lasting refrigerant antibacterial oral cavity cleaning and nursing liquid of the present embodiment is chlorination 16 except bacteriostatic agent
Alkyl pyridine and Ag+Mixture, and cetylpyridinium chloride and Ag+Weight ratio be 3:8 and both total consumptions be
Outside 0.1% (percentage by weight), remaining is with embodiment 6.
The preparation method of the lasting refrigerant antibacterial oral cavity cleaning and nursing liquid of the present embodiment is with embodiment 6.
Embodiment 13
The preparing raw material of the lasting refrigerant antibacterial oral cavity cleaning and nursing liquid of the present embodiment is poly- except high molecular polymer
Vinylpyrrolidone, and outside its consumption is 10%, remaining is with embodiment 6.
The preparation method of the lasting refrigerant antibacterial oral cavity cleaning and nursing liquid of the present embodiment is with embodiment 6.
Embodiment 14
The preparing raw material of the lasting refrigerant antibacterial oral cavity cleaning and nursing liquid of the present embodiment is first except high molecular polymer
Base vinylether-maleic acid glycosides copolymer, and outside its consumption is 10%, remaining is with embodiment 6.
The preparation method of the lasting refrigerant antibacterial oral cavity cleaning and nursing liquid of the present embodiment is with embodiment 6.
Embodiment 15
Oral cavity cleaning and nursing liquid effect example
By obtained oral cavity cleaning and nursing liquid in embodiment 1～3 and blank sample (in addition to without polyacrylate, remaining
Proportioning is the same, and few amount is filled in the water yield) refrigerant degree duration running is carried out, test method is to select to cool degree more sensitivity
Crowd 60, scores according to following standard degree persistence refrigerant to oral cavity cleaning and nursing liquid.
Refrigerant degree persistence evaluation criterion
Effect data
From the results, it was seen that with the help of high molecular polymer polyacrylate, oral cavity cleaning and nursing formula of liquid one
The refrigerant persistence of obtained oral cavity cleaning and nursing liquid has and is obviously improved.
By oral cavity cleaning and nursing liquid obtained in embodiment 4～6 and blank sample (except without polyvinylpyrrolidone, methyl
Vinylether-maleic acid glycosides copolymerization beyond the region of objective existence, remaining proportioning are the same, and few amount is filled in the water yield), oral cavity obtained in embodiment 7～9
Cleaning-nursing liquid carries out antibacterial persistence test, and test method is to select 150 oral cavity gingivitis patients, is randomly divided into 3
Group, one group uses oral cavity cleaning and nursing liquid obtained in embodiment 4～6, and one group uses blank sample oral cavity cleaning and nursing liquid, finally
One group use oral cavity cleaning and nursing liquid obtained in embodiment 7～9, after oral cavity cleaning and nursing liquid has been used, to oral cavity flora (with
Porphyromonas gingivalis, Fusobacterium nucleatum, Candida albicans, Prevotella intermedia, lactobacillus acidophilus are monitoring objective) little every 2
When be monitored, altogether monitor 12 hours, data are as follows：
From the results, it was seen that in high molecular polymer polyvinylpyrrolidone, methyl vinyl ether-maleic acid glycosides copolymerization
In the presence of thing, the oral cavity cleaning and nursing liquid sample of the less pbz polymer polymer of oral cavity cleaning and nursing liquid obtained in embodiment 4～9
Product have obvious lifting in bacteriostasis property persistence, and also oral cavity cleaning and nursing can be obtained from embodiment 10～12
Liquid is found out, in the presence of high molecular polymer polyvinylpyrrolidone, methyl vinyl ether-maleic acid glycosides copolymer, compounding
Using bacteriostatic agent Ag+Ag is used alone with cetylpyridinium chloride contrast+When, bacteriostasis property is more preferably more longlasting.As space is limited,
The bacteriostasis rate of each embodiment is not listed one by one in upper table, and it is clear that the bacteriostasis rate in upper table is respectively oral cavity obtained in embodiment 4～9
The average bacteriostasis rate of cleaning and nursing liquid, the average bacteriostasis rate of blank control group and oral cavity cleaning and nursing obtained in embodiment 10～12
The average bacteriostasis rate of liquid.According to result of the test, the fungistatic effect of embodiment 10 is significantly better than embodiment 4 and 7, the suppression of embodiment 11
Bacterium effect is significant is better than embodiment 5 and 8, and the fungistatic effect of embodiment 12 is significantly better than embodiment 6 and 9, averagely antibacterial with using
The result that rate is represented is consistent.
Additionally, test proves that the using effect of persistently refrigerant antibacterial oral cavity cleaning and nursing liquid obtained in embodiment 6 is better than
The effect of persistently refrigerant antibacterial oral cavity cleaning and nursing liquid obtained in embodiment 13 and embodiment 14, obtained in embodiment 6 persistently
Refrigerant antibacterial oral cavity cleaning and nursing liquid is refrigerant to spend that the duration is longer, and bacteriostasis rate is higher under comparable conditions.
Last should be noted that above example is only in order to illustrating technical scheme rather than protect to of the invention
The restriction of shield scope, although being explained in detail to the present invention with reference to preferred embodiment, one of ordinary skill in the art should
Understand, technical scheme can be modified or equivalent, without deviating from the essence of technical solution of the present invention
And scope.
Claims (10)
1. a kind of persistently refrigerant antibacterial oral cavity cleaning and nursing liquid, it is characterised in that：The preparation of the oral cavity cleaning and nursing liquid is former
Material includes：NMF, foaming agent, solubilizer, flavoring essence, water and persistently refrigerant antibacterial composition；
The composition includes following components：Freshener and bacteriostatic agent and the macromolecule that can be complexed with the bacteriostatic agent
Polymer.
2. persistently refrigerant antibacterial oral cavity cleaning and nursing liquid according to claim 1, it is characterised in that：By weight
Meter, in the composition, the consumption of each component is：0.2～4 part of freshener, 0.01～4 part of bacteriostatic agent and high molecular polymer 0.1
～20 parts.
3. persistently refrigerant antibacterial oral cavity cleaning and nursing liquid according to claim 1, it is characterised in that：The freshener bag
Include menthol, menthyl lactate, amide of mint, menthyl acetate, menthone glycerol ketals, WS-23, WS-5 and theirs is derivative
At least one in thing.
4. persistently refrigerant antibacterial oral cavity cleaning and nursing liquid according to claim 1, it is characterised in that：The bacteriostatic agent bag
Include o- cymene -5- alcohol, nano-silver ionic Ag+, in cetylpyridinium chloride and Dialkyl dimethyl ammonium chloride class at least
A kind of.
5. persistently refrigerant antibacterial oral cavity cleaning and nursing liquid according to claim 4, it is characterised in that：The bacteriostatic agent bag
Include o- cymene -5- alcohol, nano-silver ionic Ag+, in cetylpyridinium chloride and Dialkyl dimethyl ammonium chloride class at least
Two kinds.
6. persistently refrigerant antibacterial oral cavity cleaning and nursing liquid according to claim 1, it is characterised in that：The polyphosphazene polymer
Compound includes acrylic copolymer and vinyl-based copolymer.
7. persistently refrigerant antibacterial oral cavity cleaning and nursing liquid according to claim 1, it is characterised in that：By weight percentage
Densimeter, comprising following preparing raw material：NMF 4～50%, foaming agent 1～3%, solubilizer 0.1～3%, flavoring essence 0.2
～2%, ethanol 0～40%, persistently refrigerant antibacterial composition 0.31～28%, balance of water.
8. persistently refrigerant antibacterial oral cavity cleaning and nursing liquid according to claim 1, it is characterised in that：The preparing raw material
Also comprising sweetener and pigment.
9. persistently refrigerant antibacterial oral cavity cleaning and nursing liquid according to claim 1, it is characterised in that：The NMF bag
Include at least one in sorbierite, polyethylene glycol, propane diols, glycerine；
The solubilizer includes at least one in tween -8, rilanit special；
The foaming agent is included in lauryl sodium sulfate, moon silicic acid sodium sarcosinate, Cocoamidopropyl betaine, APG
At least one.
10. the preparation method of the lasting refrigerant antibacterial oral cavity cleaning and nursing liquid according to any one of claim 1～9,
It is characterized in that：Comprise the following steps：The NMF, high molecular polymer, foaming agent, water are well mixed, A group groups are obtained
Point；The solubilizer, bacteriostatic agent, essence, ethanol, freshener are well mixed, B group components are obtained；By A groups component and B group components
It is well mixed, obtains final product the oral cavity cleaning and nursing liquid.
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| CN107485584A (en) * | 2017-07-28 | 2017-12-19 | 鹰仕达（中国）有限公司 | A kind of oral care composition |
| CN107595750A (en) * | 2017-07-28 | 2018-01-19 | Dj健康产业集团 | A kind of active inflammation-diminishing toothpaste |
| CN108371640A (en) * | 2017-11-29 | 2018-08-07 | 江西炫尼诗科技有限责任公司 | A kind of mock-strawberry oral nursing liquid and preparation method thereof |
| CN111973535A (en) * | 2020-09-10 | 2020-11-24 | 李时珍国灸集团蕲艾产业(蕲春)有限公司 | Folium artemisiae argyi washing-free disinfection gel and preparation method thereof |
| CN112675058A (en) * | 2020-12-31 | 2021-04-20 | 泰州市榕兴医疗用品股份有限公司 | Antibacterial and cool oral cleaning composition and application thereof |
| CN113563986A (en) * | 2021-09-01 | 2021-10-29 | 高梵(浙江)信息技术有限公司 | Down jacket cleaning agent with anti-fouling function |
| CN115531313A (en) * | 2022-09-06 | 2022-12-30 | 杭州先康医疗科技有限公司 | Antibacterial liquid and preparation method and application thereof |
| CN116390718A (en) * | 2021-01-29 | 2023-07-04 | 孙益民 | Mucoadhesive drug delivery |
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| CN107280987A (en) * | 2017-06-27 | 2017-10-24 | 上海中翊日化有限公司 | A kind of water base prescription of cymene and its application in preparation for external application to skin |
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| CN107595750A (en) * | 2017-07-28 | 2018-01-19 | Dj健康产业集团 | A kind of active inflammation-diminishing toothpaste |
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| CN108371640A (en) * | 2017-11-29 | 2018-08-07 | 江西炫尼诗科技有限责任公司 | A kind of mock-strawberry oral nursing liquid and preparation method thereof |
| CN111973535A (en) * | 2020-09-10 | 2020-11-24 | 李时珍国灸集团蕲艾产业(蕲春)有限公司 | Folium artemisiae argyi washing-free disinfection gel and preparation method thereof |
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| CN116390718A (en) * | 2021-01-29 | 2023-07-04 | 孙益民 | Mucoadhesive drug delivery |
| CN113563986A (en) * | 2021-09-01 | 2021-10-29 | 高梵(浙江)信息技术有限公司 | Down jacket cleaning agent with anti-fouling function |
| CN115531313A (en) * | 2022-09-06 | 2022-12-30 | 杭州先康医疗科技有限公司 | Antibacterial liquid and preparation method and application thereof |
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