CN101998851A - 吡铂和西妥昔单抗治疗结直肠癌的用途 - Google Patents
吡铂和西妥昔单抗治疗结直肠癌的用途 Download PDFInfo
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- CN101998851A CN101998851A CN2009801110152A CN200980111015A CN101998851A CN 101998851 A CN101998851 A CN 101998851A CN 2009801110152 A CN2009801110152 A CN 2009801110152A CN 200980111015 A CN200980111015 A CN 200980111015A CN 101998851 A CN101998851 A CN 101998851A
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- Prior art keywords
- cetuximab
- dosage
- pyrrole platinum
- patient
- tetrahydrofolic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
血清肌酐 | 2期FOLPI对象的剂量变化 |
≤规范ULN | 推荐剂量 |
>1.0至1.5倍ULN | 降低30mg/m2吡铂 |
>1.5至2.0倍ULN | 降低60mg/m2吡铂 |
>2.0倍ULN | 停止吡铂治疗 |
Claims (76)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2738208P | 2008-02-08 | 2008-02-08 | |
US2738708P | 2008-02-08 | 2008-02-08 | |
US2736008P | 2008-02-08 | 2008-02-08 | |
US61/027,360 | 2008-02-08 | ||
US61/027,387 | 2008-02-08 | ||
US61/027,382 | 2008-02-08 | ||
PCT/US2009/000773 WO2009099651A1 (en) | 2008-02-08 | 2009-02-06 | Use of picoplatin and cetuximab to treat colorectal cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
CN101998851A true CN101998851A (zh) | 2011-03-30 |
Family
ID=40952402
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2009801110152A Pending CN101998851A (zh) | 2008-02-08 | 2009-02-06 | 吡铂和西妥昔单抗治疗结直肠癌的用途 |
CN2009801101399A Pending CN102014624A (zh) | 2008-02-08 | 2009-02-06 | 治疗肺癌的吡铂和氨柔比星 |
CN2009801097586A Pending CN102006875A (zh) | 2008-02-08 | 2009-02-06 | 吡铂和贝伐单抗治疗结直肠癌的用途 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2009801101399A Pending CN102014624A (zh) | 2008-02-08 | 2009-02-06 | 治疗肺癌的吡铂和氨柔比星 |
CN2009801097586A Pending CN102006875A (zh) | 2008-02-08 | 2009-02-06 | 吡铂和贝伐单抗治疗结直肠癌的用途 |
Country Status (7)
Country | Link |
---|---|
US (3) | US20110052581A1 (zh) |
EP (3) | EP2249827A4 (zh) |
JP (3) | JP2011511074A (zh) |
CN (3) | CN101998851A (zh) |
AU (3) | AU2009210656A1 (zh) |
CA (3) | CA2715353A1 (zh) |
WO (3) | WO2009099634A2 (zh) |
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US8168661B2 (en) * | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
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2009
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- 2009-02-06 JP JP2010545885A patent/JP2011511074A/ja not_active Withdrawn
- 2009-02-06 WO PCT/US2009/000750 patent/WO2009099634A2/en active Application Filing
- 2009-02-06 US US12/866,702 patent/US20110052580A1/en not_active Abandoned
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- 2009-02-06 AU AU2009210656A patent/AU2009210656A1/en not_active Abandoned
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- 2009-02-06 EP EP09708527A patent/EP2244714A4/en not_active Withdrawn
- 2009-02-06 EP EP09708292A patent/EP2249644A4/en not_active Withdrawn
- 2009-02-06 CN CN2009801110152A patent/CN101998851A/zh active Pending
- 2009-02-06 AU AU2009210734A patent/AU2009210734A1/en not_active Abandoned
- 2009-02-06 CA CA2715348A patent/CA2715348A1/en not_active Abandoned
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AU2009210656A1 (en) | 2009-08-13 |
WO2009099634A3 (en) | 2010-01-21 |
AU2009210734A1 (en) | 2009-08-13 |
US20110053879A1 (en) | 2011-03-03 |
US20110052581A1 (en) | 2011-03-03 |
EP2249644A2 (en) | 2010-11-17 |
JP2011511074A (ja) | 2011-04-07 |
EP2244714A1 (en) | 2010-11-03 |
JP2011511072A (ja) | 2011-04-07 |
EP2249644A4 (en) | 2012-05-30 |
WO2009099649A1 (en) | 2009-08-13 |
CN102006875A (zh) | 2011-04-06 |
CN102014624A (zh) | 2011-04-13 |
US20110052580A1 (en) | 2011-03-03 |
WO2009099651A1 (en) | 2009-08-13 |
JP2011511071A (ja) | 2011-04-07 |
CA2715329A1 (en) | 2009-08-13 |
WO2009099634A2 (en) | 2009-08-13 |
EP2249827A1 (en) | 2010-11-17 |
EP2249827A4 (en) | 2012-05-30 |
CA2715348A1 (en) | 2009-08-13 |
AU2009210654A1 (en) | 2009-08-13 |
EP2244714A4 (en) | 2012-06-06 |
CA2715353A1 (en) | 2009-08-13 |
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