CN101974063A - 一种山茶皂苷b2的制备方法 - Google Patents
一种山茶皂苷b2的制备方法 Download PDFInfo
- Publication number
- CN101974063A CN101974063A CN 201010535344 CN201010535344A CN101974063A CN 101974063 A CN101974063 A CN 101974063A CN 201010535344 CN201010535344 CN 201010535344 CN 201010535344 A CN201010535344 A CN 201010535344A CN 101974063 A CN101974063 A CN 101974063A
- Authority
- CN
- China
- Prior art keywords
- saponin
- tsubaki
- ethanol
- preparation
- reflux
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title claims abstract description 8
- YDGQDJXYFVWQDO-UHFFFAOYSA-N camelliasaponin B1 Natural products CC=C(/C)C(=O)OC1CC(C)(C)CC2C3=CCC4C5(C)CCC(OC6OC(CO)C(O)C(OC7OCC(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C6OC9OC(CO)C(O)C(O)C9O)C(C)(C=O)C5CCC4(C)C3(C)CC(O)C12CO YDGQDJXYFVWQDO-UHFFFAOYSA-N 0.000 title abstract description 5
- MGTOPLIWMNGFCQ-UHFFFAOYSA-N camelliasaponin B2 Natural products O=CC1(C)C2CCC3(C)C4(C)CC(O)C5(CO)C(OC(=O)C(C)=CC)CC(C)(C)CC5C4=CCC3C2(C)CCC1OC(C1OC2C(C(O)C(O)C(CO)O2)O)OC(C(O)=O)C(O)C1OC1OCC(O)C(O)C1OC1OC(CO)C(O)C(O)C1O MGTOPLIWMNGFCQ-UHFFFAOYSA-N 0.000 title abstract description 5
- MGTOPLIWMNGFCQ-PGGKNCGUSA-N camelliasaponin b2 Chemical compound O=CC1(C)C2CCC3(C)C4(C)CC(O)C5(CO)C(OC(=O)C(/C)=C/C)CC(C)(C)CC5C4=CCC3C2(C)CCC1OC(C1OC2C(C(O)C(O)C(CO)O2)O)OC(C(O)=O)C(O)C1OC1OCC(O)C(O)C1OC1OC(CO)C(O)C(O)C1O MGTOPLIWMNGFCQ-PGGKNCGUSA-N 0.000 title abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 42
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000011347 resin Substances 0.000 claims abstract description 14
- 229920005989 resin Polymers 0.000 claims abstract description 14
- 238000000605 extraction Methods 0.000 claims abstract description 13
- 239000012046 mixed solvent Substances 0.000 claims abstract description 13
- 238000010992 reflux Methods 0.000 claims abstract description 12
- 239000002904 solvent Substances 0.000 claims abstract description 12
- 238000004064 recycling Methods 0.000 claims abstract description 8
- 238000001035 drying Methods 0.000 claims abstract description 7
- 235000018597 common camellia Nutrition 0.000 claims abstract description 6
- 238000002425 crystallisation Methods 0.000 claims abstract description 6
- 230000008025 crystallization Effects 0.000 claims abstract description 6
- 239000000706 filtrate Substances 0.000 claims abstract description 6
- 238000010438 heat treatment Methods 0.000 claims abstract description 6
- 238000005406 washing Methods 0.000 claims abstract description 6
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 22
- 230000006837 decompression Effects 0.000 claims description 15
- 238000002360 preparation method Methods 0.000 claims description 13
- 238000011084 recovery Methods 0.000 claims description 10
- 239000003463 adsorbent Substances 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 6
- 239000002699 waste material Substances 0.000 claims description 6
- 240000001548 Camellia japonica Species 0.000 claims description 5
- 230000000274 adsorptive effect Effects 0.000 claims description 5
- KTUQUZJOVNIKNZ-UHFFFAOYSA-N butan-1-ol;hydrate Chemical compound O.CCCCO KTUQUZJOVNIKNZ-UHFFFAOYSA-N 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 5
- 238000010828 elution Methods 0.000 claims description 5
- 238000001640 fractional crystallisation Methods 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 2
- 230000001476 alcoholic effect Effects 0.000 claims description 2
- 241000209507 Camellia Species 0.000 abstract description 3
- 239000000047 product Substances 0.000 abstract description 2
- 239000013078 crystal Substances 0.000 abstract 1
- 239000003480 eluent Substances 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
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- Steroid Compounds (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201010535344A CN101974063B (zh) | 2010-11-09 | 2010-11-09 | 一种山茶皂苷b2的制备方法 |
Applications Claiming Priority (1)
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---|---|---|---|
CN201010535344A CN101974063B (zh) | 2010-11-09 | 2010-11-09 | 一种山茶皂苷b2的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101974063A true CN101974063A (zh) | 2011-02-16 |
CN101974063B CN101974063B (zh) | 2012-10-03 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201010535344A Expired - Fee Related CN101974063B (zh) | 2010-11-09 | 2010-11-09 | 一种山茶皂苷b2的制备方法 |
Country Status (1)
Country | Link |
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CN (1) | CN101974063B (zh) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101301401A (zh) * | 2008-06-18 | 2008-11-12 | 沈阳药科大学 | 山茶花有效成分及其提取方法和用途 |
CN101392015A (zh) * | 2008-07-22 | 2009-03-25 | 沈阳药科大学 | 山茶种子中的三萜皂苷及其制备方法和医药用途 |
-
2010
- 2010-11-09 CN CN201010535344A patent/CN101974063B/zh not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101301401A (zh) * | 2008-06-18 | 2008-11-12 | 沈阳药科大学 | 山茶花有效成分及其提取方法和用途 |
CN101392015A (zh) * | 2008-07-22 | 2009-03-25 | 沈阳药科大学 | 山茶种子中的三萜皂苷及其制备方法和医药用途 |
Non-Patent Citations (1)
Title |
---|
《Chem.Pharm.Bull》 19961031 Massyuki Yoshikawa et.al Bioactive saponins and glycosides.V. acylated polyhydroxyolean-12-ene triterpene oligoglycosides, camelliasaponins A1, A2, B1, B2, C1, and C2, from the seeds of Camellia japonica L.: structures and inhibitory activity on alcohol absorption 1899-1907 1-7 第44卷, 第10期 * |
Also Published As
Publication number | Publication date |
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CN101974063B (zh) | 2012-10-03 |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: NANTONG WEIHE MARINE PARTS CO., LTD. Free format text: FORMER OWNER: SUZHOU PAITENG BIOPHARMACEUTICAL TECHNOLOGY CO., LTD. Effective date: 20131121 |
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C41 | Transfer of patent application or patent right or utility model | ||
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Free format text: CORRECT: ADDRESS; FROM: 215011 SUZHOU, JIANGSU PROVINCE TO: 226000 NANTONG, JIANGSU PROVINCE |
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TR01 | Transfer of patent right |
Effective date of registration: 20131121 Address after: 226000, No. 687, Changtai Road, City Industrial Park, street town, Nantong, Gangzha, Jiangsu Patentee after: Nantong Weihe shipboard Fittings Co. Ltd. Address before: 215011 Jiangsu high tech Zone Suzhou City Binhe Road, No. 1326 Patentee before: Suzhou Paiteng Biopharmaceutical Technology Co., Ltd. |
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TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20180917 Address after: 226000 639 north outer ring road, Nantong, Jiangsu Patentee after: NANTONG BEICHENG SCIENCE & TECHNOLOGY ENTREPRENEURIAL MANAGEMENT CO., LTD. Address before: 226000 Nantong road Gangzha District, Jiangsu Province Tang Gate Town Street Industrial Park, Changtai road 687 Patentee before: Nantong Weihe shipboard Fittings Co. Ltd. |
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CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20121003 Termination date: 20191109 |
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CF01 | Termination of patent right due to non-payment of annual fee |