CN101966290A

CN101966290A - Medicament for treating neurasthenia and preparation method thereof

Info

Publication number: CN101966290A
Application number: CN2010102954641A
Authority: CN
Inventors: 申东升
Original assignee: Individual
Current assignee: Individual
Priority date: 2010-09-29
Filing date: 2010-09-29
Publication date: 2011-02-09

Abstract

The invention discloses a medicament for treating neurasthenia, which is prepared by the following steps of: adding water to decoct Chinese angelica, szechwan lovage rhizome, raw white paeony root, the dried rhizome of rehmannia, mother of pearl, fried jujube seed, platycladi seed, fried bighead atractylodes rhizome, fragrant solomonseal rhizome, fructus schisandrae, common macrocarpium fruit, medlar and liquorice twice, 2 to 4 hours each time, concentrating decoction into cream with the temperature of 50 DEG C and the relative density of 1.04 to 1.05, drying under reduced pressure, crushing into fine powder, and uniformly mixing to obtain a capsule product. The medicament has the effects of nourishing liver and kidney, dispersing stagnated liver qi for relieving qi stagnation, nourishing spleen and regulating qi, enriching blood to nourish the heart, and tranquilizing mind, treats the neurasthenia based on syndrome differentiation from holistic approach, treats the principal aspect quickly and the secondary aspect slowly, has exact curative effect for treating the neurasthenia, and has the effective rate of 92.8 percent through clinical observation.

Description

Neurasthenic medicine of a kind of treatment and preparation method thereof

Technical field

The present invention relates to the neurasthenic medicine of a kind of treatment, particularly relating to a kind of is the neurasthenic medicine of treatment of crude drug preparation with Chinese medicine, and the preparation method of this medicine.

Background technology

The neurasthenia is a kind of spirituality obstacle, because people's cerebral cortex is in excited for a long time and suppresses irregular state, causes patient's cerebral vasospasm, and cerebral blood flow reduces, the cerebral oxygen supply deficiency, and function of brain cell goes down.Clinical manifestation is that patient daytime is often sleepy, sleepy, weak, drowsiness, then has a sleepless night night, dreaminess, has lost normal person's excitement and inhibition temporal regularity.Studies show that work, study hypertonicity are acted hurriedly in a messy situation, it is irregular to have a rest and sleep, and operating pressure is big, and health is in subhealth state, and feels to have burden and unhappy emotion etc., is to cause neurasthenic main cause.

The western medical treatment neurasthenia mainly relies on to stabilize and waits the tranquilizer symptomatic treatment of sleeping peacefully at present, but there is defective in these medicines aspect safety and the dependency, and side effect is bigger, forms addiction and drug resistance easily, so should not take for a long time.

Summary of the invention

It is little to the purpose of this invention is to provide a kind of toxic and side effects, and outstanding effect is treated neurasthenic Chinese medicine medicine.

Medicine of the present invention is that crude drug prepares by following parts by weight of traditional Chinese medicines:

Radix Angelicae Sinensis 10～15 Rhizoma Chuanxiongs 15～20 Radix Paeoniae Alba 15～20

The Radix Rehmanniae 15～20 Concha Margaritiferas 30～40 Semen Ziziphi Spinosae (parched)s 15～20

Semen Platycladi 10～20 Rhizoma Atractylodis Macrocephalae (parched)s 5～10 Rhizoma Polygonati Odorati 5～10

Fructus Schisandrae Chinensis 10～15 mountain cornels 20～25 Fructus Lycii 20～25

Radix Glycyrrhizae 3～5.

Said medicine can be made any peroral dosage form on the pharmaceutics, as tablet, pill, watered pill, powder, capsule etc., the preferred dosage form of the present invention is a capsule.

The concrete preparation method of above-mentioned each crude drug being made medicine of the present invention is:

Getting Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Alba, the Radix Rehmanniae, Concha Margaritifera, Semen Ziziphi Spinosae (parched), Semen Platycladi, Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Polygonati Odorati, Fructus Schisandrae Chinensis, mountain cornel, Fructus Lycii, Radix Glycyrrhizae by above-mentioned parts by weight decocts with water 2 times, each amount of water is 3～4 times of crude drug gross weight, decoct 2～4h, collecting decoction filters, concentrate the clear paste of 50 ℃ of relative densities 1.04～1.05, drying under reduced pressure is ground into fine powder, mixing, encapsulated, promptly.

Usage: the adult takes 2 at every turn, and is every day 2 times, oral.

Motherland's medical science thinks that the neurasthenia belongs to scopes such as " being insomnia ", " cardiopalmus ", " strongly fragrant disease ", " deficient ", " seminal emission ", " sexual impotence ", how to be hindered by feelings will, and spiritual hypertonicity, or after the serious disease prolonged illness due to the visceral dysfunction.If disgruntled smooth, depression and stagnation of QI, gas lose catharsis and then cause depression of liver-QI; Work with one's mind and think become homeless foster, dysfunction of the spleen in transportation, source of generating QI and blood deficiency of void, the stagnation of liver-QI impairment of the spleen, insufficiency of the spleen insufficiency of blood, the heart and then cause deficiency of both the heart and spleen; Stagnation of liver-QI with the passing of time, fire-transformation impairment of YIN, deficiency of kidney yin, the kidney failing to nourish the liver, the liver imbalance is supported and is then caused the hepatic and renal YIN deficiency; Deficiency of the kidney or excess of sexual intercourse, injure kidney yang, smart close solid, decline of the fire from the gate of life and then cause insufficiency of kidney-YANG.In the prescription of the present invention, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Alba blood circulation promoting and blood stasis dispelling, nourishing blood for regulating menstruation; Radix Rehmanniae clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, blood circulation promoting and blood stasis dispelling; Concha Margaritifera, Semen Ziziphi Spinosae (parched), Semen Platycladi, mountain cornel, Fructus Lycii mind tranquilizing and the heart calming, promoting the production of body fluid to quench thirst, strong muscle kidney tonifying, reinforcing the heart is enriched blood, tranquillizing the mind by relieving convulsion; The Radix Glycyrrhizae invigorating the spleen and replenishing QI, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.All medicine compatibilities, nourishing the liver and kidney, soothing liver-QI for relieving depression, spleen invigorating are regulated the flow of vital energy, replenishing blood for nourishing heart, sedate are calmed the nerves, and carry out determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs from the integral body sight, symptomatic treatment in acute condition, relieving the primary symptom in a chronic case, treatment neurasthenia determined curative effect.

Medicine patient of the present invention is easy to take, and takes safety, can reduce complication and take place, and clinical effectiveness is good, and easy to use, and price is suitable.

For further investigating the clinical efficacy and the safety of medicine of the present invention, select 500 routine neurasthenias that the curative effect of medicine of the present invention is carried out clinical observation.

500 routine cases are divided into two groups at random, every group 250 example.Male 123 examples in the matched group, women 127 examples; 17～54 years old age, average 48.3 years old; The course of disease 1～55 month, average 4.9 months.Male 128 examples in the treatment group, women 122 examples; 18～43 years old age, average 47.3 years old; Course of disease 15d～25 month, average 3.8 months.Two groups of cases at aspects such as sex, age, the courses of disease by statistics credit analyse the difference not statistically significant.The diagnosis of all cases is diagnosed with reference to neurasthenic diagnostic criteria in " neurological ", and meets diagnostic criteria.

Therapeutic Method: matched group is urged brain cell metabolism and psychotherapy with alprazolam anxiety, vitamin B group trophic nerve, citicoline.The treatment group gives medicine of the present invention, and each 2, every day 2 times, oral meal.

Curative effect determinate standard: recovery from illness: clinical symptom disappearance does not influence operate as normal study; Produce effects: sleep quality improves, and appetite increases, and symptoms such as headache, dizziness, fatigue and weak take a turn for the better, and memory increases; Effectively: above-mentioned symptom makes moderate progress; Invalid: treatment back clinical symptoms no change.

Curative effect comparative result after two groups of cases are treated sees Table 1.

Table 1 liang group case treatment back curative effect relatively

The specific embodiment

Embodiment 1

Medicine is chosen most impurity, screening dry in the sun, after the oven dry, take by weighing Radix Angelicae Sinensis 10Kg, Rhizoma Chuanxiong 15Kg, Radix Paeoniae Alba 15Kg, Radix Rehmanniae 15Kg, Concha Margaritifera 30Kg, Semen Ziziphi Spinosae (parched) 15Kg, Semen Platycladi 10Kg, Rhizoma Atractylodis Macrocephalae (parched) 5Kg, Rhizoma Polygonati Odorati 5Kg, Fructus Schisandrae Chinensis 10Kg, mountain cornel 20Kg, Fructus Lycii 20Kg, Radix Glycyrrhizae 3Kg, add 3 times to the water of medical material weight, decoct 4h, leach decocting liquid, the decocting that adds 3 times of weight of medical material again boils 3h, leaches decocting liquid, collecting decoction, filter, be concentrated into the clear paste of 50 ℃ of relative densities 1.05, drying under reduced pressure, be ground into fine powder, mixing, encapsulated, promptly.Usage: the adult takes 2 at every turn, and is every day 2 times, oral.

Embodiment 2

Medicine is chosen most impurity, screening dry in the sun, after the oven dry, take by weighing Radix Angelicae Sinensis 12Kg, Rhizoma Chuanxiong 16Kg, Radix Paeoniae Alba 18Kg, Radix Rehmanniae 18Kg, Concha Margaritifera 32Kg, Semen Ziziphi Spinosae (parched) 18Kg, Semen Platycladi 12Kg, Rhizoma Atractylodis Macrocephalae (parched) 8Kg, Rhizoma Polygonati Odorati 8Kg, Fructus Schisandrae Chinensis 12Kg, mountain cornel 22Kg, Fructus Lycii 22Kg, Radix Glycyrrhizae 5Kg, add 3 times to the water of medical material weight, decoct 4h, leach decocting liquid, the decocting that adds 3 times of weight of medical material again boils 3h, leaches decocting liquid, collecting decoction, filter, be concentrated into the clear paste of 50 ℃ of relative densities 1.05, drying under reduced pressure, be ground into fine powder, mixing, encapsulated, promptly.

Claims

1. neurasthenic medicine of treatment is that crude drug prepares by the Chinese medicine of following portions by weight:

Radix Glycyrrhizae 3～5.

2. the neurasthenic medicine of treatment according to claim 1 is characterized in that described medicine is made capsule.

3. the preparation method of the neurasthenic medicine of the described treatment of claim 2, it is characterized in that according to described parts by weight, getting Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Alba, the Radix Rehmanniae, Concha Margaritifera, Semen Ziziphi Spinosae (parched), Semen Platycladi, Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Polygonati Odorati, Fructus Schisandrae Chinensis, mountain cornel, Fructus Lycii, Radix Glycyrrhizae decocts with water 2 times, each amount of water is 3～4 times of crude drug gross weight, decoct 2～4h, collecting decoction, filter, be concentrated into the clear paste of 50 ℃ of relative densities 1.04～1.05, drying under reduced pressure is ground into fine powder, mixing, encapsulated, promptly.