CN101926875A - Gel for treating gynecologic inflammation and preparation method thereof - Google Patents
Gel for treating gynecologic inflammation and preparation method thereof Download PDFInfo
- Publication number
- CN101926875A CN101926875A CN2009103074345A CN200910307434A CN101926875A CN 101926875 A CN101926875 A CN 101926875A CN 2009103074345 A CN2009103074345 A CN 2009103074345A CN 200910307434 A CN200910307434 A CN 200910307434A CN 101926875 A CN101926875 A CN 101926875A
- Authority
- CN
- China
- Prior art keywords
- parts
- gel
- water
- ethanol
- add
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses Kangfu gel for treating gynecologic inflammation and a preparation method thereof. The gel is prepared from extract extracted from angelica dahurica, common cnidium fruit, wild pepper and elecampane inula root serving as medicinal raw materials, borneol, auxiliary materials and an appropriate amount of water. The Kangfu gel is a new Chinese medicinal formulation for treating the gynecologic inflammation and is an improved formulation of the conventional Kangfu ointment. The conventional Kangfu ointment is prepared into external gel, so that formulation varieties are enriched to meet different demands of different patients, curative effect is enhanced, response is quick, tract administration is facilitated and the gel is convenient to use. The method has the advantages of simple and convenient production process, convenient control of product quality, high stability and high safety. A prepared gel preparation is convenient to use and has the remarkable effect of treating the gynecologic inflammation.
Description
Technical field
The present invention relates to a kind of Chinese medicine for external application for the treatment of gynecological inflammation and preparation method thereof, particularly a kind of health woman's gel preparation for the treatment of gynecological inflammation and preparation method thereof belongs to the technical field of medicine.
Background technology
Health woman's ointment is the present Chinese medicine preparation of the treatment gynecological inflammation of extensive use clinically, be mainly used in pudendum that vulvitis, vulval ulcer, vaginitis etc. cause or vaginal congest, swelling, scorching hot, pain, secretions increase or local ulcer, erosion, pruritus etc., have better therapeutic effect.But existing health woman's ointment formulation kind is single, and the reliability of the stability of product quality and curative effect is all relatively poor and be unfavorable for cavity/canal drug administration, and the patient uses inconvenience, can not satisfy the needs in market fully.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of health woman's gel of treatment gynecological inflammation rapid-action, easy to use, this health woman is provided the preparation method of gel simultaneously, thereby overcomes traditional existing deficiency of health woman's ointment.
For solving the problems of the technologies described above technical scheme of the present invention: health woman's gel of treatment gynecological inflammation.According to 1000 parts of meters of weight portion, it is 50～150 parts of the extractum that extracted by the raw medicinal material Radix Angelicae Dahuricae, Fructus Cnidii, Pericarpium Zanthoxyli and Radix Inulae and 30 parts of Borneolum Syntheticums and adjuvant and suitable quantity of water are prepared from; Adjuvant wherein is disodiumedetate, carbomer, propylene glycol, ethanol, azone and ethyl hydroxybenzoate, the weight proportion of each adjuvant is 0～2 part of disodiumedetate, 10～40 parts of carbomers, 400～600 parts of propylene glycol, 80～140 parts of ethanol, 1～20 part of azone, 0～3 part of ethyl hydroxybenzoate, and all the other are water.
In health woman's gel of above-mentioned treatment gynecological inflammation, according to listed as parts by weight, each raw medicinal material weight proportion preferably is: 145 parts of the Radixs Angelicae Dahuricae, 145 parts of Fructus Cnidiis, 145 parts in Pericarpium Zanthoxyli, 30 parts of Radix Inulaes.
In health woman's gel of aforesaid treatment gynecological inflammation, each component weight proportion preferably is, raw medicinal material extracts 80～120 parts of extractum, 30 parts of Borneolum Syntheticums, 0～1 part of disodiumedetate, 20～35 parts of carbomers, 450～550 parts of propylene glycol, 90～130 parts of ethanol, 5～15 parts of azones, 0～2 part of ethyl hydroxybenzoate, and all the other are water.
In health woman's gel of aforesaid treatment gynecological inflammation, the better weight proportion of each component is, raw medicinal material extracts 100 parts of extractum, 30 parts of Borneolum Syntheticums, 0.3 part of disodiumedetate, 30 parts of carbomers, 500 parts of propylene glycol, 120 parts of ethanol, 10 parts of azones, 1 part of ethyl hydroxybenzoate, and all the other are water.
The preparation method of health woman's gel of treatment gynecological inflammation may further comprise the steps:
1), get the Radix Angelicae Dahuricae, Fructus Cnidii, Pericarpium Zanthoxyli and Radix Inulae four flavor raw medicinal materials, add the water distillation 2～4 hours of 8～12 times of amounts, collect Aromatic water and decocting liquid respectively;
2), above-mentioned Aromatic water was carried out redistillation 30～90 minutes, rectification liquid;
3), above-mentioned decocting liquid is filtered, surveying relative density when filtrate is concentrated into 25 ℃ is 1.15～1.22, adds ethanol and makes that to contain the alcohol amount be 70%, leaves standstill, get supernatant and transfer pH value to 8.0 with 10% sodium hydroxide solution, standing over night is got supernatant, reclaim ethanol, sterilization gets medicinal liquid;
4), get disodiumedetate and be dissolved in water after, add carbomer, stir evenly, left standstill 12～24 hours, stir evenly, carbomer gel;
5), get propylene glycol, add ethanol, azone, ethyl hydroxybenzoate, Borneolum Syntheticum, medicinal liquid, rectification liquid successively, behind the mixing, merge with above-mentioned carbomer gel, add suitable quantity of water and stir evenly, promptly.
In the preparation method of health woman's gel of above-mentioned treatment gynecological inflammation, be preferably in the step (1) and get the water distillation 3.5 hours that the Radix Angelicae Dahuricae, Fructus Cnidii, Pericarpium Zanthoxyli and Radix Inulae four flavor raw medicinal materials add 10 times of amounts.
In the preparation method of health woman's gel of aforesaid treatment gynecological inflammation, be preferably in the step (2) Aromatic water was carried out redistillation 30 minutes.
Beneficial effect of the present invention: health woman's gel of the present invention is a kind of Chinese medicine novel form that is used for the treatment of gynecological inflammation, and it is the improvement dosage form of traditional health woman's ointment, is a kind of useful of existing dosage form replenished.By traditional health woman's ointment is made external-use gel, improved curative effect and rapid-action, help cavity/canal drug administration, the patient is easy to use.Compared with prior art, production technology of the present invention is easy, and product quality is convenient to control, good stability, and safe, the gel preparation of making is easy to use, and the treatment of gynecological inflammation is had significant effect.The present invention has simultaneously enriched the dosage form kind, and to satisfy the different needs of extensive patients, market prospect is wide.
Each single medical material and pharmacological action thereof are as follows in the prescription of health woman's gel of the present invention: the Radix Angelicae Dahuricae, have the effect of diffusing wind dehumidifying, understand things pain-stopping, detumescence and apocenosis, and be used for headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection and swell and ache.Fructus Cnidii has warming the kidney to invigorate YANG, dampness, dispels the wind, parasiticidal effect, is used for sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; The external treatment vulval eczema, married woman's pudendal pruritus, trichomonal vaginitis.Pericarpium Zanthoxyli has the effect of warming middle-JIAO to relieve pain, killing parasites for relieving itching, is used for that coldness and pain in the epigastrium, vomiting are had loose bowels, abdominal pain due to worm stagnation, ascariasis; External treatment eczema pruritus.Radix Inulae has invigorating the spleen and regulating the stomach, promoting the flow of QI for relieving the stagnancy, the antiabortive effect of pain relieving, be used for the breast side of body, abdominal distention, vomiting dysentery, the breast side of body dampen, feel a pain in the chest when breathing have a pain, frequent fetal movement.Borneolum Syntheticum has the effect of the refreshment of having one's ideas straightened out, clearing away heat to alleviate pain, is used for calentura coma, convulsions, stagnation of QI sudden syncope, attacked by pestiferous factors stupor, conjunctival congestion, aphtha, laryngopharynx swelling and pain, auditory meatus and suppurates.
Health woman's gel of the present invention has inhibitory action to various bacteria, pathogenic microorganism, parasite etc., also has analgesia, antiinflammatory, antiinflammation.
Clinical practice:, carried out clinical practice and observation with the different syndromes of health woman's gel of the present invention at the patient.
1, treatment pruritus vulvae: amount to 326 examples, the result: 298 examples that closely heal, 21 examples that take a turn for the better, total effective rate 97.85%.
2, treatment vaginitis: amount to 100 examples, the result: obvious effective rate is 86%, total effective rate 90%.
3, treatment cervical erosion: amount to 715 examples, the result: I degree cure rate is 98.28%, and II degree cure rate is 77.19%, and III degree cure rate is 28.13%.
4, treatment chronic cervicitis: amount to 68 examples, the result: effective percentage is 92.6%.
5, treatment pudendum lichen: amount to 82 examples, the result: 62 examples through 1～2 the course of treatment transference cure, the leucorrhea smear is looked into all turning out cloudy property of mycete, infusorian, recovery from illness is left hospital; 16 examples were fully recovered through 3 courses of treatment; 4 routine produce effects are slow, and the course of treatment is long slightly.
6, treatment leukoplakia vulvae: amount to 105 examples, the result: clinical cure 35 examples, produce effects 26 examples, 38 examples that take a turn for the better, invalid 6 examples, total effective rate is 94.3%, has no side effect and untoward reaction.
7, treatment perineum side cutting mouthfeel is dyed: 447 examples, satisfactory effect are infected in control.
8, treatment perineum spontaneous perspiration: amount to 57 examples, 40 examples are cured equal 1 course of treatment, and all the other were cured through several courses of treatment.
Technical study of the present invention is as follows:
1, Study on extraction
1.1, the present invention on extraction process, for replenishment of process, volatile oil extraction time has been carried out following investigation, research.
Get four Chinese medicine material 465g such as the Radix Angelicae Dahuricae, vapor distillation is collected distillate, puts in the round-bottomed flask, measures the volatilization oil mass with volatile oil extractor, the results are shown in Table 1.
Table 1
| Time (h) | The fragrance water yield (ml) | Put forward oil mass (ml) |
| 2? | 296? | 3.6? |
| 3? | 430? | 4.1? |
| 3.5? | 510? | 4.3? |
| 4? | 590? | 4.3? |
As shown in Table 1, carry oil after 3.5 hours, the volatilization oil mass is basicly stable, is 3.5 hours so determine to carry the oil time.This moment, Aromatic water was about 500ml.
1.2, the determining of rectification time.
Get four Chinese medicine material 465g such as the Radix Angelicae Dahuricae, vapor distillation 3.5 hours is collected Aromatic water, measures the volatilization oil mass according to the method under 1.1, the results are shown in Table 2.
Table 2
| Time (min) | Put forward oil mass (ml) |
| 30? | 4.0? |
| 60? | 4.1? |
| 90? | 4.2? |
As shown in Table 2, Aromatic water rectification is after 30 minutes, and the volatilization oil mass is basicly stable, so determine that the rectification time is 30 minutes.
2, amount of water determines.
Get four Chinese medicine material 465g such as the Radix Angelicae Dahuricae, add 8,10,12 times of water gagings respectively, added thermal distillation 3.5 hours, device is collected Aromatic water in addition, and decocting liquid filters, and filtrate is concentrated into the clear paste of relative density 1.20 (25 ℃).Measure the content of osthole, the results are shown in Table 3.
Table 3
As shown in Table 3, the osthole total amount of 10 times of amounts and 12 times of amount gained is suitable, and is high than 8 times of amounts, takes all factors into consideration, so it is comparatively suitable to select to add 10 times of water gagings extractions.
The extraction process that gets health woman gel according to above result of study is to get the water distillation 3.5 hours that the Radix Angelicae Dahuricae, Fructus Cnidii, Pericarpium Zanthoxyli, Radix Inulae four flavor crude drug add 10 times of amounts, collects Aromatic water and decocting liquid respectively; Aromatic water carried out redistillation 30 minutes, got rectification liquid.Decocting liquid filters, and filtrate is concentrated into relative density 1.15～1.22 (25 ℃).Add ethanol and make that to contain alcohol amount be 70%, leave standstill, get supernatant and transfer pH value to 8.0 with 10% sodium hydroxide solution, standing over night is got supernatant, reclaims ethanol to there not being the alcohol flavor, and the steam sterilization 30 minutes of circulating promptly gets medicinal liquid.
3, the optimization of pharmaceutical formulation.
The optimization of pharmaceutical formulation is tested by the orthogonal design scheme of three factors, three levels, and is all plastic 2.5～3.5% according to the trial test carbomer.Thereby three levels of carbomer are made as 2.5%, 3%, 3.5%, and the horizontal consumption of each of solvent is determined by solubility test, observes the dissolving situation at the solvent Chinese medicine of Different concentrations of alcohol and propylene glycol, to determine the scope of three levels.Table 4 is orthogonal design schemes:
Table 4 empirical factor water-glass
According to above technology collocation, be felt as index evaluation with diffusibility with smearing, optimum combination is A3B2C2, i.e. ethanol 12%, propylene glycol 50%, carbomer 3%.
The present invention is further illustrated below in conjunction with the specific embodiment.
The specific embodiment
Embodiment 1.Health woman's gel raw material prescription is: Radix Angelicae Dahuricae 145g, Fructus Cnidii 145g, Pericarpium Zanthoxyli 145g, Radix Inulae 30g, Borneolum Syntheticum 30g.
The gel prescription is: raw medicinal material extracts extractum 100g, Borneolum Syntheticum 30g, and disodiumedetate 0.3g, carbomer 30g, propylene glycol 500g, ethanol 120g, azone 10g, ethyl hydroxybenzoate 1g, all the other are water, amount to 1000g.During preparation, get the water distillation 3.5 hours that the Radix Angelicae Dahuricae, Fructus Cnidii, Pericarpium Zanthoxyli, Radix Inulae four flavor raw medicinal materials add 10 times of amounts, collect Aromatic water and decocting liquid respectively; Aromatic water is carried out redistillation 30 minutes, get rectification liquid.Above-mentioned decocting liquid is filtered, and filtrate is concentrated into relative density 1.15～1.22 (25 ℃).Add ethanol and make that to contain alcohol amount be 70%, leave standstill, get supernatant and transfer pH value to 8.0 with 10% sodium hydroxide solution, standing over night is got supernatant, reclaims ethanol to there not being the alcohol flavor, the steam sterilization 30 minutes of circulating, medicinal liquid.After getting EDTA-2Na0.3g and being dissolved in water, add carbomer, stir evenly, left standstill 12～24 hours, stir evenly, carbomer gel.Get propylene glycol 500g, add ethanol 120g, azone 10g, ethyl hydroxybenzoate 1g, Borneolum Syntheticum 30g, medicinal liquid, rectification liquid successively, behind the mixing, merge, stir evenly, add suitable quantity of water and make 1000g, promptly get health woman's gel of the present invention with above-mentioned carbomer gel.
Embodiment 2.Health woman's gel raw material prescription: Radix Angelicae Dahuricae 145g, Fructus Cnidii 145g, Pericarpium Zanthoxyli 145g, Radix Inulae 30g, Borneolum Syntheticum 30g.
The gel prescription is: raw medicinal material extracts extractum 100g, Borneolum Syntheticum 30g, and disodiumedetate 0.3g, carbomer 30g, propylene glycol 500g, ethanol 120g, azone 10g, ethyl hydroxybenzoate 1g, all the other are water, amount to 1000g.During preparation, get the water distillation 2 hours that the Radix Angelicae Dahuricae, Fructus Cnidii, Pericarpium Zanthoxyli, Radix Inulae four flavor raw medicinal materials add 8 times of amounts, collect Aromatic water and decocting liquid respectively.Aromatic water carried out redistillation 30 minutes, got rectification liquid.Decocting liquid filters, and filtrate is concentrated into relative density 1.15～1.22 (25 ℃).Add ethanol and make that to contain alcohol amount be 70%, leave standstill, get supernatant and transfer pH value to 8.0 with 10% sodium hydroxide solution, standing over night is got supernatant, reclaims ethanol to there not being the alcohol flavor, and circulation steam sterilization 30 minutes gets medicinal liquid.After getting disodiumedetate 0.3g and being dissolved in water, add carbomer, stir evenly, left standstill 12～24 hours, stir evenly, carbomer gel.Get propylene glycol 500g, add ethanol 120g, azone 10g, ethyl hydroxybenzoate 1g, Borneolum Syntheticum 30g, medicinal liquid, rectification liquid successively, behind the mixing, merge, stir evenly, add suitable quantity of water and make 1000g, promptly get health woman's gel of the present invention with above-mentioned carbomer gel.
Embodiment 3.Health woman's gel raw material prescription: Radix Angelicae Dahuricae 145g, Fructus Cnidii 145g, Pericarpium Zanthoxyli 145g, Radix Inulae 30g, Borneolum Syntheticum 30g.
The gel prescription is: raw medicinal material extracts extractum 100g, Borneolum Syntheticum 30g, and disodiumedetate 0.3g, carbomer 30g, propylene glycol 500g, ethanol 120g, azone 10g, ethyl hydroxybenzoate 1g, all the other are water, amount to 1000g.During preparation, get the water distillation 4 hours that the Radix Angelicae Dahuricae, Fructus Cnidii, Pericarpium Zanthoxyli, Radix Inulae four flavor raw medicinal materials add 12 times of amounts, collect Aromatic water and decocting liquid respectively.Aromatic water carried out redistillation 90 minutes, got rectification liquid.Decocting liquid filters, and filtrate is concentrated into relative density 1.15～1.22 (25 ℃).Add ethanol and make that to contain alcohol amount be 70%, leave standstill, get supernatant and transfer pH value to 8.0 with 10% sodium hydroxide solution, standing over night is got supernatant, reclaims ethanol to there not being the alcohol flavor, and the steam sterilization 30 minutes of circulating promptly gets medicinal liquid.After getting disodiumedetate 0.3g and being dissolved in water, add carbomer, stir evenly, left standstill 12～24 hours, stir evenly, carbomer gel.Get propylene glycol 500g, add ethanol 120g, azone 10g, ethyl hydroxybenzoate 1g, Borneolum Syntheticum 30g, medicinal liquid, rectification liquid successively, behind the mixing, merge, stir evenly, add suitable quantity of water and make 1000g, promptly get health woman's gel of the present invention with above-mentioned carbomer gel.
Embodiment 4.Health woman's gel raw material prescription: Radix Angelicae Dahuricae 145g, Fructus Cnidii 145g, Pericarpium Zanthoxyli 145g, Radix Inulae 30g, Borneolum Syntheticum 30g.
The gel prescription is: raw medicinal material extracts extractum 50g, Borneolum Syntheticum 30g, and disodiumedetate 0.1g, carbomer 10g, propylene glycol 400g, ethanol 80g, azone 1g, ethyl hydroxybenzoate 0.1g, all the other are water, amount to 1000g.During preparation, get the water distillation 3.5 hours that the Radix Angelicae Dahuricae, Fructus Cnidii, Pericarpium Zanthoxyli, Radix Inulae four flavor crude drug add 10 times of amounts, collect Aromatic water and decocting liquid respectively.Aromatic water carried out redistillation 30 minutes, got rectification liquid.Decocting liquid filters, and filtrate is concentrated into relative density 1.15～1.22 (25 ℃).Add ethanol and make that to contain alcohol amount be 70%, leave standstill, get supernatant and transfer pH value to 8.0 with 10% sodium hydroxide solution, standing over night is got supernatant, reclaims ethanol to there not being the alcohol flavor, and the steam sterilization 30 minutes of circulating promptly gets medicinal liquid.After getting disodiumedetate 0.1g and being dissolved in water, add carbomer, stir evenly, left standstill 12～24 hours, stir evenly, carbomer gel.Get propylene glycol 400g, add ethanol 80g, azone 1g, ethyl hydroxybenzoate 0.1g, Borneolum Syntheticum 30g, medicinal liquid, rectification liquid successively, behind the mixing, merge, stir evenly, add suitable quantity of water and make 1000g, promptly get health woman's gel of the present invention with above-mentioned carbomer gel.
Embodiment 5.Health woman's gel raw material prescription: Radix Angelicae Dahuricae 145g, Fructus Cnidii 145g, Pericarpium Zanthoxyli 145g, Radix Inulae 30g, Borneolum Syntheticum 30g.
The gel prescription is: raw medicinal material extracts extractum 150g, Borneolum Syntheticum 30g, and disodiumedetate 2g, carbomer 40g, propylene glycol 600g, ethanol 140g, azone 20g, ethyl hydroxybenzoate 3g, all the other are water, amount to 1000g.During preparation, get the water distillation 3.5 hours that the Radix Angelicae Dahuricae, Fructus Cnidii, Pericarpium Zanthoxyli, Radix Inulae four flavor crude drug add 10 times of amounts, collect Aromatic water and decocting liquid respectively.Aromatic water carried out redistillation 30 minutes, got rectification liquid.Decocting liquid filters, and filtrate is concentrated into relative density 1.15～1.22 (25 ℃).Add ethanol and make that to contain alcohol amount be 70%, leave standstill, get supernatant and transfer pH value to 8.0 with 10% sodium hydroxide solution, standing over night is got supernatant, reclaims ethanol to there not being the alcohol flavor, and the steam sterilization 30 minutes of circulating promptly gets medicinal liquid.After getting disodiumedetate 2g and being dissolved in water, add carbomer, stir evenly, left standstill 12～24 hours, stir evenly, carbomer gel.Get propylene glycol 600g, add ethanol 140g, azone 20g, ethyl hydroxybenzoate 3g, Borneolum Syntheticum 30g, medicinal liquid, rectification liquid successively, behind the mixing, merge, stir evenly, add suitable quantity of water and make 1000g, promptly get health woman's gel of the present invention with above-mentioned carbomer gel.
Embodiments of the present invention are not limited to the foregoing description, and the various variations of making under the prerequisite that does not break away from aim of the present invention all belong within protection scope of the present invention.
Claims (7)
1. health woman's gel for the treatment of gynecological inflammation is characterized in that: according to 1000 parts of meters of weight portion, 50～150 parts of extractum that is extracted by the raw medicinal material Radix Angelicae Dahuricae, Fructus Cnidii, Pericarpium Zanthoxyli and Radix Inulae and 30 parts of Borneolum Syntheticums and adjuvant and suitable quantity of water are prepared from; Adjuvant wherein is disodiumedetate, carbomer, propylene glycol, ethanol, azone and ethyl hydroxybenzoate, the weight proportion of each adjuvant is 0～2 part of disodiumedetate, 10～40 parts of carbomers, 400～600 parts of propylene glycol, 80～140 parts of ethanol, 1～20 part of azone, 0～3 part of ethyl hydroxybenzoate, and all the other are water.
2. health woman's gel of treatment gynecological inflammation according to claim 1 is characterized in that: according to listed as parts by weight, the weight proportion of each raw medicinal material is: 145 parts of the Radixs Angelicae Dahuricae, 145 parts of Fructus Cnidiis, 145 parts in Pericarpium Zanthoxyli, 30 parts of Radix Inulaes.
3. health woman's gel of treatment gynecological inflammation according to claim 1, it is characterized in that: each composition weight proportioning is, raw medicinal material extracts 80～120 parts of extractum, 30 parts of Borneolum Syntheticums, 0～1 part of disodiumedetate, 20～35 parts of carbomers, 450～550 parts of propylene glycol, 90～130 parts of ethanol, 5～15 parts of azones, 0～2 part of ethyl hydroxybenzoate, and all the other are water.
4. health woman's gel of treatment gynecological inflammation according to claim 3, it is characterized in that: each composition weight proportioning is, raw medicinal material extracts 100 parts of extractum, 30 parts of Borneolum Syntheticums, 0.3 part of disodiumedetate, 30 parts of carbomers, 500 parts of propylene glycol, 120 parts of ethanol, 10 parts of azones, 1 part of ethyl hydroxybenzoate, and all the other are water.
5. preparation method as health woman's gel of any described treatment gynecological inflammation among the claim 1-4 is characterized in that: may further comprise the steps,
1), get the Radix Angelicae Dahuricae, Fructus Cnidii, Pericarpium Zanthoxyli and Radix Inulae four flavor raw medicinal materials, add the water distillation 2～4 hours of 8～12 times of amounts, collect Aromatic water and decocting liquid respectively;
2), above-mentioned Aromatic water was carried out redistillation 30～90 minutes, rectification liquid;
3), above-mentioned decocting liquid is filtered, surveying relative density when filtrate is concentrated into 25 ℃ is 1.15～1.22, adds ethanol and makes that to contain the alcohol amount be 70%, leaves standstill, get supernatant and transfer pH value to 8.0 with 10% sodium hydroxide solution, standing over night is got supernatant, reclaim ethanol, sterilization gets medicinal liquid;
4), get disodiumedetate and be dissolved in water after, add carbomer, stir evenly, left standstill 12～24 hours, stir evenly, carbomer gel;
5), get propylene glycol, add ethanol, azone, ethyl hydroxybenzoate, Borneolum Syntheticum, medicinal liquid, rectification liquid successively, behind the mixing, merge with above-mentioned carbomer gel, add suitable quantity of water and stir evenly, promptly.
6. the preparation method of health woman's gel of treatment gynecological inflammation according to claim 5 is characterized in that: in the described step (1), be to get the water distillation 3.5 hours that the Radix Angelicae Dahuricae, Fructus Cnidii, Pericarpium Zanthoxyli and Radix Inulae four flavor raw medicinal materials add 10 times of amounts.
7. the preparation method of health woman's gel of treatment gynecological inflammation according to claim 5 is characterized in that: in the described step (2), be that Aromatic water was carried out redistillation 30 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009103074345A CN101926875A (en) | 2009-09-22 | 2009-09-22 | Gel for treating gynecologic inflammation and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009103074345A CN101926875A (en) | 2009-09-22 | 2009-09-22 | Gel for treating gynecologic inflammation and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101926875A true CN101926875A (en) | 2010-12-29 |
Family
ID=43366478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009103074345A Pending CN101926875A (en) | 2009-09-22 | 2009-09-22 | Gel for treating gynecologic inflammation and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101926875A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895386A (en) * | 2012-10-31 | 2013-01-30 | 贵州健兴药业有限公司 | Method for performing extraction on angelica dahurica, common cnidium fruit, Chinese red pepper and elecampane inula root and pharmaceutical application |
| CN105770239A (en) * | 2016-05-19 | 2016-07-20 | 庹朝彦 | External health gel for treating gynecological inflammation |
| CN107661494A (en) * | 2017-11-20 | 2018-02-06 | 方晓东 | It is a kind of to be used for gynaecological imflammation, the Chinese medicine composition gel of koro and its production technology |
| CN113384631A (en) * | 2021-07-20 | 2021-09-14 | 吉林玉仁制药股份有限公司 | Antibacterial liquid and preparation method and application thereof |
-
2009
- 2009-09-22 CN CN2009103074345A patent/CN101926875A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895386A (en) * | 2012-10-31 | 2013-01-30 | 贵州健兴药业有限公司 | Method for performing extraction on angelica dahurica, common cnidium fruit, Chinese red pepper and elecampane inula root and pharmaceutical application |
| CN102895386B (en) * | 2012-10-31 | 2014-03-05 | 贵州健兴药业有限公司 | Method for performing extraction on angelica dahurica, common cnidium fruit, Chinese red pepper and elecampane inula root and pharmaceutical application |
| CN105770239A (en) * | 2016-05-19 | 2016-07-20 | 庹朝彦 | External health gel for treating gynecological inflammation |
| CN107661494A (en) * | 2017-11-20 | 2018-02-06 | 方晓东 | It is a kind of to be used for gynaecological imflammation, the Chinese medicine composition gel of koro and its production technology |
| CN113384631A (en) * | 2021-07-20 | 2021-09-14 | 吉林玉仁制药股份有限公司 | Antibacterial liquid and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103610948A (en) | Traditional Chinese medicine composition for treating hypertension | |
| CN103007124B (en) | Chinese medicine preparation for treating gynecologic inflammation | |
| CN104740458A (en) | Pruritus treating traditional Chinese medicine composition | |
| CN103877536A (en) | Traditional Chinese medicine composition for treating diarrhea as well as preparation and application thereof | |
| CN105168385A (en) | Antibacterial and itching-relieving medicine composition and preparing method thereof | |
| CN101926875A (en) | Gel for treating gynecologic inflammation and preparation method thereof | |
| CN101972466A (en) | Traditional Chinese medicine cataplasm capable of rapidly relieving pain of dysmenorrhea and regulating menstruation and preparation method thereof | |
| CN103690670A (en) | Traditional Chinese medicine pill for treating syndrome of spleen and kidney yang deficiency | |
| CN103393857B (en) | Drug for curing hepatitis and preparation method thereof | |
| CN101391065B (en) | Compound momordica seed pepper soup for treating urgent chronic pelvic inflammatory disease | |
| CN101288754A (en) | Huyuebao preparation | |
| CN103735934B (en) | A kind of medicine for the treatment of flank pain and preparation method thereof | |
| CN102048776A (en) | Gelata for treating gynecologic inflammation and preparation method thereof | |
| CN102579677B (en) | Chinese medicinal composition for treating brain glioma | |
| CN102138989B (en) | Chinese medicinal ointment for treating scalding, and preparation method and application thereof | |
| CN104225174A (en) | Traditional Chinese medicine ointment for treating cold injury and preparation method of traditional Chinese medicine ointment | |
| CN105194427A (en) | Traditional Chinese medicine composition for treating xerophthalmia and preparation method of traditional Chinese composition | |
| CN103656312B (en) | Traditional Chinese medicinal composition for treating urinary retention after colorectal surgery | |
| CN103223098A (en) | Traditional Chinese medicine pressure reduction tea | |
| CN103599272B (en) | Chinese herbal lotion for the treatment of gynecological inflammation and preparation method thereof | |
| CN102688453A (en) | Traditional Chinese medicine composite for treating breast cancer | |
| CN102451330A (en) | Traditional Chinese medicine for treating sterility due to blood stasis | |
| CN106266014A (en) | One is used for treating tachycardic Chinese medicine composition and preparation method thereof | |
| CN105396007A (en) | Gynecological topical lotion for preventing and treating colpitis mycotica | |
| CN105194165A (en) | Traditional Chinese medicine used for treating infection of urinary system and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20101229 |