CN105396007A - Gynecological topical lotion for preventing and treating colpitis mycotica - Google Patents

Abstract

The invention provides a gynecological topical lotion for preventing and treating colpitis mycotica. The gynecological topical lotion is prepared from, by weight, 10-20 parts of radix stemonae, 10-20 parts of cortex phellodendri, 10-20 parts of radix sophorae flavescentis, 10-20 parts of fructus kochiae, 10-20 parts of dittany bark, 10-20 parts of radix angelica sinensis, 10-20 parts of senecio scandens, 10-20 parts of rhizoma smilacis glabrae, 10-20 parts of campsis grandiflora, 10-20 parts of mint, 10-20 parts of shikonin, 10-20 parts of rhizoma bletillae, 10-20 parts of herba leonuri, 10-20 parts of philippine violet herb, 10-20 parts of caulis Spatholobi, 10-20 parts of fructus cnidii, 10-20 parts of Patrinia scadiosaetolia Fiach, 10-20 parts of scutellaria baicalensis, 10-20 parts of folium artemisiae argyi, 10-20 parts of gingko and 10-20 parts of semen euryales. Compared with the prior art, the gynecological topical lotion has the advantages of being rapid in itching relief, thorough in sterilization, strong in inflammation diminishing and mite removal effect, good in inflammation resistant and itching relief effect, convenient to apply, easy to prepare, low in cost, safe, small in toxic and side effect, convenient to use, short in cure time and free of relapse after cure.

Description

A kind of gynecopathy external use cleaning liquid preventing and treating colpitis mycotica

Technical field

The present invention relates to the health product containing deriving from plant, animal or mineral component, particularly a kind of gynaecologic washing lotion preventing and treating colpitis mycotica.

Background technology

Investigation display, adult female's infection in various degree in the whole world about 87% gynecological inflammation, clinical common gynecological inflammation has vaginitis, cervicitis, endometritis etc.Clinically gynecological inflammation main manifestations be pruritus of vagina, scorching hotly to swell and ache, the symptom such as leucorrhoea grow in quantity, frequent micturition, urgent micturition, dysurea, recurrent exerbation, does not prolongedly heal, and affects quality of life and love life.

Healthy women, pudendum is only by clean water, and there is self-cleaning function vagina inside, need not clean.If do not have disease, but use washing liquid to clean everyday, will vagina be stimulated, affect the secretion of lactic acid, break normal flora and sour environment, thus reduce the resistance of human body.

Gynecological inflammation often imply that disease, so must regularly see the doctor, and treats under physician guidance.Washing liquid is only the health-care assistance measure after disease is clear and definite, can not replace medical treatment.Present medical producer releases oneself Women's washing lotion brand one after another, wherein mostly belongs to Chinese medicine preparation, the effect can play sterilization, cleaning.

In addition, also have following western medicine compositions in part gynaecologic washing lotion, Main Function suppresses pathogenic bacteria to grow, and maintains the normal weak acid environment of intravaginal: chlorhexidine acetate: Candida albicans, gonococcal bacteriostasis and sterilization.Chlorhexidine acetate: the sterilization being applicable to skin and mucosa; The flushing of traumatic infection, vaginal infection and cervical erosion.

Vulvitis is common gynecological disease, and modern medicine is thought, primary disease can be divided into specificity and nonspecific infection two kinds.Specificity vulvitis is based on mycete, trichomonacide, non-specific vulvitis is based on staphylococcus, escherichia coli, streptococcal infection etc., clinical more common with nonspecific infection, other local or general diseases can be secondary in addition, as diseases such as cervicitis, vaginitis, cervical cancers, because of the stimulation of secretions increase, or the stimulation that menses, lochiorrhagia are excessively of a specified duration, all can cause inflammation in various degree.

Women's special physiological conditioned pathogen is much breeding place with vagina, can because of women's monthly endocrine transition, affect vagina PH condition, be conducive to the active breeding of this kind of bacterial parasite, increasing number, become morbidity key element, produce local pruritus, scorching hot, mucosa is red and swollen, hyperemia, even can make mucosa dermexanthesis or erosion.Stimulate vaginal secretions to increase, the product pseudomembrane of microorganism (fungus or infusorian) forms cotton-shaped leucorrhea thereupon, or the secretion of foam sample is overflowed, and bad smell day by day increases weight.During vagina microbial reproduction, men and women's sexual intercourse, very easily becomes the infected chance of male, causes the generation of Prepuce balanitis.Infect local and produce redness, dermexanthesis, erosion, sepage and scorching hot, series of symptoms of itching.

After wherein some patients protopathy (as mycete or trichomonal vaginitis) is cured, pruritus vulvae symptom still can not be alleviated.Current doctor trained in Western medicine there is no specific short.The various genitourinary system inflammation of antibiotic therapy gynecological and the inferior effect of TONGJINGDAI very undesirable, by this type of gynaecopathia of western medicine, not only weak curative effect, easily recur, and side effect is large, does not have again specific Chinese patent medicine.Clinically make decoction oral with Chinese physician with disease foreign side, and some Chinese medicine lotions, but therapeutic effect is all not satisfactory, also exists and can bring out the deficiencies such as drug resistance, relapse rate is high, medication is inconvenient, preparation is difficult.And at present publicly for the medicine of gynaecologic washing lotion, as: " grace prestige board " JIEERYIN XIYE, still can not reach desirable antiinflammatory, antipruritic effect.

Many patients urgently wish there is a kind of external used medicine easy to use and effective, for preventing and treating various types of colpitis mycotica, can reach treating both the principal and secondary aspects of a disease, within support outside, and to have no side effect, easy to use, healing time is short, the gynaecologic washing lotion not easily recurred after healing.

Summary of the invention

Technical problem to be solved by this invention is, due to vagina special construction, women ignores health at ordinary times, or occupies dark and damp ground for a long time, so that damp invades vagina, or feelings are not smooth, and pathogenic fire derived from stagnation of liver-QI, insufficiency of the spleen resulting in production of dampness, the damp and hot strongly fragrant note part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, all can send out as pudendal pruritus.The Western medicine medicine for the treatment of gynecological is a lot, and have antibacterials as metronidazole, ciprofloxacin etc., microecologic cure preparation is as lactobacillus, Bacillus licheniformis.The various genitourinary system inflammation of antibiotic therapy gynecological and the inferior effect of TONGJINGDAI very undesirable, by this type of gynaecopathia of western medicine, not only weak curative effect, easily recur, and side effect is large, do not have again specific Chinese patent medicine, clinically make decoction oral with Chinese physician with disease foreign side, and some Chinese medicine lotions, but therapeutic effect is all not satisfactory, also exists and can bring out the deficiencies such as drug resistance, relapse rate is high, medication is inconvenient, preparation is difficult.Now in the urgent need to providing a kind of instant effect, side effect is little, biocidal property is strong, Anti-Puritic and insecticidal effect washing liquid rapidly, can efficient solution except the misery of patient, treat gynecological's colpitis mycotica.

For solving the problems of the technologies described above, the invention provides a kind of gynecopathy external use cleaning liquid preventing and treating colpitis mycotica, in described washing liquid, the parts by weight of various crude drug are: the Radix Stemonae 10 ~ 20 parts, Cortex Phellodendri 10 ~ 20 parts, Radix Sophorae Flavescentis 10 ~ 20 parts, the Fructus Kochiae 10 ~ 20 parts, Cortex Dictamni 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Herba Senecionis Scandentis 10 ~ 20 parts, Rhizoma Smilacis Glabrae 10 ~ 20 parts, Flos Campsis 10 ~ 20 parts, Herba Menthae 10 ~ 20 parts, Radix Arnebiae (Radix Lithospermi) 10 ~ 20 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Herba Violae 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Fructus Cnidii 10 ~ 20 parts, Patrinia scabiosaefolia Fisch grass 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Folium Artemisiae Argyi 10 ~ 20 parts, Semen Ginkgo 10 ~ 20 parts, Semen Euryales 10 ~ 20 parts.

Described a kind of gynecopathy external use cleaning liquid preventing and treating colpitis mycotica, in washing liquid described in it, the parts by weight of various crude drug can be: the Radix Stemonae 10 ~ 15 parts, Cortex Phellodendri 10 ~ 15 parts, Radix Sophorae Flavescentis 10 ~ 15 parts, the Fructus Kochiae 10 ~ 15 parts, Cortex Dictamni 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Herba Senecionis Scandentis 10 ~ 15 parts, Rhizoma Smilacis Glabrae 10 ~ 15 parts, Flos Campsis 10 ~ 15 parts, Herba Menthae 10 ~ 15 parts, Radix Arnebiae (Radix Lithospermi) 10 ~ 20 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Herba Violae 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Fructus Cnidii 10 ~ 20 parts, Patrinia scabiosaefolia Fisch grass 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Folium Artemisiae Argyi 10 ~ 20 parts, Semen Ginkgo 10 ~ 20 parts, Semen Euryales 10 ~ 20 parts.

Described a kind of gynecopathy external use cleaning liquid preventing and treating colpitis mycotica, in washing liquid described in it, the parts by weight of various crude drug can also be: the Radix Stemonae 10 ~ 20 parts, Cortex Phellodendri 10 ~ 20 parts, Radix Sophorae Flavescentis 10 ~ 20 parts, the Fructus Kochiae 10 ~ 20 parts, Cortex Dictamni 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Herba Senecionis Scandentis 10 ~ 20 parts, Rhizoma Smilacis Glabrae 10 ~ 20 parts, Flos Campsis 10 ~ 20 parts, Herba Menthae 10 ~ 20 parts, Radix Arnebiae (Radix Lithospermi) 10 ~ 15 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, Herba Violae 10 ~ 15 parts, Caulis Spatholobi 10 ~ 15 parts, Fructus Cnidii 10 ~ 15 parts, Patrinia scabiosaefolia Fisch grass 10 ~ 15 parts, Radix Scutellariae 10 ~ 15 parts, Folium Artemisiae Argyi 10 ~ 15 parts, Semen Ginkgo 10 ~ 15 parts, Semen Euryales 10 ~ 15 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of preventing and treating the gynecopathy external use cleaning liquid of colpitis mycotica, it is characterized in that, the preparation process of described washing liquid comprises:

A. described crude drug is put into pulverizer grinding and sieving except Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Folium Artemisiae Argyi and Semen Euryales,

B. the particulate matter be left after sieving is put into ethanol heating and refluxing extraction 2 times;

C. the medicinal residues after above-mentioned ethanol extraction are got again, the heating and refluxing extraction that adds water 2 times;

D. above-mentioned two kinds of extracting solution are merged concentrated;

E. Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Folium Artemisiae Argyi and the Semen Euryales way of distillation are vaporized into white crystalline powder;

F. the white crystalline powder of vaporization is poured in concentrated solution and mix, add metronidazole solution and stir, canned after disinfection by ultraviolet light.

In described step a, described crude drug can be put into except Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Folium Artemisiae Argyi and Semen Euryales after pulverizer is pulverized and cross 100 order dusting covers, the enable fine powder amount by 100 mesh sieves is reaching 30%, collects by the raw material fine powder of 100 mesh sieves for subsequent use.

In described step b, the coarseparticulate be left after sieving can be put into ethanol heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution be merged and leaves standstill;

In described step c, the medicinal residues that above-mentioned ethanol extraction is crossed can be added 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution be merged and leaves standstill.

In described steps d, above-mentioned two kinds of extracting solution can be merged, when concentrating under reduced pressure relative density is 80 DEG C 1.37 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.06, stir evenly after adding the fine powder sieved.Pour in 0.5% metronidazole solution.

In described step e, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Folium Artemisiae Argyi and the Semen Euryales way of distillation can be vaporized into white crystals, powdered after dry, collect for subsequent use.

In described step f, concentrated medicinal liquid can be added the white crystalline powder mixing of vaporization, pour in 0.5% metronidazole solution and stir, with canned after disinfection by ultraviolet light.

Treatment takes washout or demibain, each 20 ~ 30mL, every day 2 times.General was 1 course for the treatment of with 10d, observe the curative effect after 2 ~ 3 courses for the treatment of.

Compared with prior art teach, the present invention has rapidly antipruritic, and thoroughly, antiinflammatory deinsectization effect is strong, and antiinflammatory, antipruritic effect are good in sterilization; And convenient drug administration, the advantages such as medicinal liquid is easy to manufacture, with low cost.And safety, toxic and side effects is little, easy to use, and healing time is short, not easily recurs after healing.Good social value and economic interests can be created.

Detailed description of the invention

From dissection, the pudendum of women is in the state of a Natural closure, ensures that the vagina discord external world communicates.Vaginal wall is also closed state at front and rear wall at ordinary times, and cervix uteri is also a closure state.In addition in addition, mediate contact infection is also a route of transmission of colpitis mycotica.Which contact article may contact by the toilet seat in the common lavatory of mycete patient infection, bathtub, bathing pool seat, towel by infected vaginitis, use unclean toilet paper, propagation can be caused, when the vulvoaginal candidiasis of infected person reaches some, mycotic vulvovaginitis can be there is.Other can cause colpitic behavior antibiotics, antibiotic medicine is that chief-criminal takes antibiotics in a large number and also can cause vaginitis.As long as used antibiotic to be oral or had an injection the balance of nature that the lactobacillus of vagina all can be suppressed to upset vagina, change the microenvironment of vagina, pathogenic antibacterial source of disease body just may have been bred, and finally causes the monilial vaginitis outbreak of local.So generally do not take Antibiotics medicine in a large number.

The various inflammation of vagina belongs to TCM Gynecology miscellaneous diseases pudendal pruritus and leukorrhagia category, and both normal companions mutually see.Pudendal pruritus and leukorrhagia have two reasons: on the one hand and endogenous cause of ill: liver,kidney,spleen malfunction closes, and the liver pulse is around external genitals, and main store blood is again viscus attriguted to wind and wood; Kidney controlling essence storage, main reproduction, have one's ideas straightened out Yu Eryin; The spleen has the function to transport and transform nutrients, and water wets.If dampness-heat of the liver or the life of stagnation of liver-QI with deficiency of the spleen fire-transformation are wet, damp and hot heresy, with through bet, pents up external genitals so pudendal pruritus; Or deficiency of the liver and kindey, blood and essence asthenia, raw air slaking are not dry, vagina failure of skin and muscle to be nourished, flourish and itch; Infect the sick worm of damp in addition on the one hand with exopathogenic factor relevant, careless because taking the photograph body, cause the sick worm of damp and invade, worm disturbs vagina, sends out as pudendal pruritus." Yizong Jinjian gynecological heart method gist " said " married woman's pudendal pruritus, how because of parasite caused by accumulation of damp-heat in the body " is namely this meaning.Obviously, the reason causing infective vaginitis should belong to the latter.Traditionally theory of Chinese medical science, caused by endogenous cause of ill, person is based on oral medicine adjustment function, and because of person caused by exterior syndrome worm or be aided with external treatment or be Main Means with external treatment.

Pudendal pruritus caused by the sick worm of infection damp, leukorrhagia person show as dampness-heat of the liver more, and thus treatment should with removing damp-heat, killing parasites for relieving itching for principle.Primary disease is mainly because of damp-heat accumulation, and in worm-eaten the moon, caused damp and hot heresy has inside and outside dividing.Cause outside damp invade as occupied wetland etc. for a long time, strongly fragrant and heat-transformation, or menstrual period, puerperal, toxic dampness and heat is taken advantage of a weak point, and this is that diseases caused by exogenous pathogenic factor are damp and hot.If ferritic deficiency-weakness of spleen-QI, or depression of liver-QI, wood gram spleen soil, dysfunction of the spleen in transportation, stay in water is wet, stopping pouring down Jiao, accumulate and heat-transformation, is then that interior life is damp and hot.Damp-heat accumulation, ligament is not solid, then leukorrhagia increases, yellow skin.Damp-heat in lower-JIAO, the excellent then concurrent stranguria of failing to keep an appointment of wing; With the passing of time damp contamination becomes poison, or infects pyretic toxicity pathogen, the absurd row of intenseness of heat forcing blood, or noxious dampness corrosion skin, then visible band defecation with blood and pus, or sees " erosion of the vulva ", " erosion of vulva ".Web rot is infested, or health preserving is careless, and worm heresy directly violates external genitals, then pudendal pruritus in worm-eaten the moon, though causalgia primary disease disease is at external genitals in the moon, often relevant with the internal organs such as liver spleen.How because damp is disease.Obviously, the reason causing infective vaginitis should belong to the latter.

Pseudobulbus Bletillae (Rhizoma Bletillae) is bitter, sweet, puckery, is slightly cold.Return lung, liver, stomach warp.Function cures mainly astringing to arrest bleeding, detumescence and promoting granulation.Spit blood for hemoptysis, traumatic hemorrhage, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.Shennong's Herbal: " main carbuncle, malignant boil, lose cellulitis, the dead flesh of impairment of YIN, pathogen in stomach "; Compendium of Material Medica: " abnormal smells from the patient (root) is bitter, flat, nontoxic.

Fructus Kochiae clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.For difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus." property of medicine opinion ": " with Actinolitum with taking, main husband's impotence does not rise, QI invigorating benefit power; Control cloudy ovum Huang disease, reduce phlegm and internal heat wind, can make soup and take a shower." to rabbit gavage, in 6 hours, urine chloride increases by 127.1% ~ 131.6% to Fructus Kochiae decoct 2g/kg, but total volume of urine is unchanged. and have report to point out, the Fructus Kochiae all has impact to rat urine volume and renal sodium excretion.

Cortex Phellodendri heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency." Chinese Pharmacopoeia " carries the power of Cortex Phellodendri heat clearing and damp drying, similar to Radix Scutellariae, Rhizoma Coptidis, but being good except the damp and hot of the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels.

Radix Sophorae Flavescentis is bitter, cold.GUIXIN, liver, stomach, large intestine, urinary bladder channel heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment colpitis mycotica, is often combined with Cortex Phellodendri, is the colpitic external use gynaecological good medicine for the treatment of.

Radix Stemonae nature and flavor sweetness and bitterness, tepor." not Lu ": tepor." property of medicine opinion ": sweet in the mouth, nontoxic." Japan hanako materia medica ": bitter in the mouth, nontoxic.Nature and flavor are sweet, bitter, tepor.Return lung meridian.Function cures mainly nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing.Cough for new chronic cough, pulmonary tuberculosis cough, pertussis; Outer for head louse, body louse, enterobiasis, vagina Pruritus.

Cortex Dictamni dispels the wind, dampness, heat clearing away, removing toxic substances.Control wind heat sore, scabies, itchy skin eruption, rheumatic arthralgia, jaundice." herbal classic ": main wind syndrome of head, jaundice, cough with dyspnea, drenches drop, swells and ache in woman's the moon, the dead flesh of arthralgia chiefly caused by damp pathogen, unable to flex and stretch the extremities, start-stop, row step.

Rhizoma Smilacis Glabrae nature and flavor: sweet light are flat.Gui Jing: Liver Channel; Stomach warp; Spleen channel.Function: removing toxic substances, dehumidifying, sharp joint.Cure mainly: control syphilis, stranguria with turbid discharge, muscles and bones spasm and pain, beriberi, furuncle treats skin ulcer, carbuncle, scrofula.

Radix Angelicae Sinensis, its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, and invigorating middle warmer has, has benefit, the gas medicine in sincere blood, the panacea also in blood in row.Then mending to mend of about assistant, therefore can nutrition blood be supported, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant to attack, lead to, therefore pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, and can fall apart greatly Biao Weire, and show not hold back person, helps with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, therefore for its quiet person when keeping away it, the sliding benefaction of property, stool does not consolidate person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, and cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.We are by the strong feature of broad-spectrum antibacterial action, are used in fungal culture miscellaneous bacteria and infect special severe, fine by Radix Scutellariae extracting solution effect." Bencao Jingshu ": Radix Scutellariae, its property is respectful clearly, so evil removing: bitter in the mouth is so dampness; YIN-cold is so victory heat, therefore main all heat.All hot persons, pathogenic heat with all over heat also, jaundice, intestinal be out-of-the-way, let out dysentery, and the disease of all damp and hot victory also, analyses it, then all diseases are from recover.Bitter cold can except damp and hot, thus small intestinal profit and water from by, source is clearly then flowed also clean.The blood person of closing, excess-heat is at blood system, and instant heating human blood room, it is obstructed to make us amenorrhea, and damp and hot solution, then Ying Qi clearly and voluntarily also.Malignant boil cellulitis erosion person, heat in blood then stays knot, and is that carbuncle stain is also rotten: acute scleritis person, also, removing heat from blood heat extraction, then spontaneous recovery also for fire of moxibustion blood trouble.Radix Scutellariae has antiallergic action and antiinflammatory action: the anaphylaxis contractile response that baicalin contained by Radix Scutellariae and baicalin can obviously suppress sensitized guinea pig rat small intestine in vitro and isolated tracheal to produce antigen, to passive general allergy and the Cavia porcellus passivity skin allergic reaction of Cavia porcellus and mice, baicalin and baicalin also have inhibitory action.Radix Scutellariae has refrigeration function, and most test proves, the active ingredient baicaligenin of Radix Scutellariae has refrigeration function.Radix Scutellariae has Detoxication, and baicalin has obvious Detoxication, and this may be that baicalin decomposites glucuronic acid due under the effect of glucuronidase, and caused by being combined with multiple poisonous substance.The LD50 that baicalin 10 milligrams can improve strychnine reaches 2.5 times, and the hepatic glycogen content of carbon tetrachloride poisoning mice is increased.

Herba Leonuri acrid in the mouth is bitter, cool.Invigorate blood circulation, silt of dispelling, regulating menstruation, disappear water.Treatment menoxenia, vaginal bleeding during pregnancy is had difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, and metrorrhagia and metrostaxis, rushes down blood, carbuncle skin infection at hematuria.Herba Leonuri alkalescence subcutaneous injection has central inhibitory action, and MLD is 0.4-0.6g/kg.Intravenous rabbit injection leonurine 1mg/kg, visible urine volume significantly increases.Leonurine can make Sanguis Leporis seu oryctolagi suspension generation haemolysis when higher concentration.Leonurine infusion tube dilution method 1: 13-1: 10, to achorion schoenleinii, Pilus Caprae seu Ovis sample sporidiole bacteria, epidermophyton rubrum, starlike nocadia all have inhibitory action.The dull and stereotyped paper disk method of Herba Leonuri decoct, has inhibitory action to escherichia coli, dysentery bacterium.Herba Leonuri can remove silt tissue regeneration promoting, promoting blood flow to regulate menstruation, containing the various trace elements such as selenium, manganese, can antioxidation, anti-aging, and there is pretty good beneficial face beauty treatment, anti-ageing anti-old effect.

Patrinia scabiosaefolia Fisch grass nature and flavor hardship is flat, has effect of heat-clearing and toxic substances removing, evacuation of pus removing blood stasis with potent drugs.Acute appendicitis, dysentery, leucorrhea with red and white discharge, the stagnant stomachache of the stasis of blood in puerperal, conjunctival congestion and swelling pain can be cured.Enter stomach, large intestine, Liver Channel.Cure mainly heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, blood circulation promoting competent silt.For acute appendicitis, lung abscess and sore and toxic, the stagnant caused breast abdomen pain of the excess-heat stasis of blood, the diseases such as the stagnant stomachache of the stasis of blood in puerperal.

A kind of Chinese medicine material of Flos Campsis, latin name Campsisgrandiflora.Have promoting the circulation of blood blood stasis removing, cooling blood, expelling wind dampness removing, heat-clearing and toxic substances removing, acrid in the mouth acid, cold nature returns liver, pericardium channel, function promoting blood circulation to remove blood stasis, cooling blood, expelling wind.Cure mainly menoxenia, amenorrhea lump in the abdomen, puerperal swelling of the breast, skin pruritus. " Amplification on Materia Medica addendum ": Flos Campsis, control the key medicine of pain in blood also, and nourishing YIN victory very, is stamped and keeps and walk alone, in married woman side multiplex what." Nanning City's medicine will ": the merit having eliminating inflammation and expelling toxin, hemostasis and pain-relieving, evacuation of pus granulation promoting, controls red Hakuri.

Caulis Spatholobi property is bitter, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carries it can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; Flos Campsis, Caulis Spatholobi is for oral administration is that treatment blood stasis is not fallen apart, and nourishing blood is become silted up the good medicine of invigorating blood circulation.

Radix Arnebiae (Radix Lithospermi) is cold in nature, sweet in the mouth, one-tenth.GUIXIN, Liver Channel.Cure mainly removing heat from blood, invigorate blood circulation, removing toxic substances rash.Contain for heat in blood poison, macule purple is black, measles without adequate eruption, skin infection, dermatomycosis, burn due to hot liquid or fire.Clearing away heat and cooling blood, for measles, calentura skin eruption, dermatomycosis, hematuria, stranguria with blood, dysentery, skin infection, separates erysipelas." book on Chinese herbal medicine justice " carries: Radix Arnebiae (Radix Lithospermi), abnormal smells from the patient bitter cold, and color purple enters blood, therefore the heat of cleaning blood system.Ancient to control the accumulation of heat of internal organs, descendant is special treatment of smallpox infections then, and hold concurrently treatment skin eruption, all positive purport of heat clearing and blood cooling.

Herba Senecionis Scandentis, has another name called Herba Hieracii Umbellati, Herba Senecionis Scandentis.Latin name HerbaSenecionisScandentis.A kind of Chinese herbal medicine, under being born in hillside, sparse woods, Lin Bian, roadside, in limes marginis thick grass.The effects such as it is cold in nature, bitter in the mouth, has heat-clearing and toxic substances removing, improving eyesight, antipruritic.Be used for anemopyretic cold, conjunctival congestion and swelling pain, dysentery, skin eczema furuncle.Supplement to the Herbal: main pestilential pathogen, knot is yellow, malaria miasma, and cup poison, boils telling down of clothes, also smash the place of biting such as deposited skin ulcer, worm Serpentis dog.

Herba Violae bitter, acrid, cold, nontoxic; GUIXIN, Liver Channel.Function cures mainly: can be used as medicine, its mildly bitter flavor cold in nature, heat-clearing and toxic substances removing, and removing heat from blood is subsided a swelling.Cure mainly jaundice, dysentery, mastitis, conjunctival congestion and swelling pain, pharyngitis; Traumatic injury, carbuncle, venom etc. are controlled in external application.When Herba Violae is used for hyperactivity of toxic heat, the medical materials such as said Flos Lonicerae, Fructus Forsythiae, Flos Chrysanthemi Indici not only can be coordinated in remarks with using, more can with Herba Patriniae and the same use of the Radix Astragali, not only strengthen the detumescence of Herba Violae, also play effect of a poison holding when controlling carbuncle equivalent force.What be kills two birds with one stone.Herba Violae has the effect suppressing growth of bacillus tubercle in vitro.Direct Microscopical Method For Detection and Tube propagation method show: Herba Violae (ethanol extract 31mg/ml, water decoction 62mg/ml) has inhibitory action to leptospira.Herba Violae water logging agent (1: 4) has inhibitory action to trichophyton in vitro.In addition, think that Herba Violae still has the effects such as heat clearing away, detumescence, antiinflammatory.

Semen Ginkgo property is put down, and sweet in the mouth is pained, slightly poisonous; Enter lung, kidney channel.Astringe the lung gas, relieving asthma and cough, leukorrhagia stopping is turbid, urine reducing, disinfection.Cure mainly asthma, phlegmatic cough, nocturnal emission, leucorrhea, nebulousurine, infantile diarrhea, malnutrition due to parasitic infestation, hemorrhoidal hamorrhage dysentery, gonorrhea, frequent micturition, and the disease such as scabies, dermatitis rhus, in vain tumor wind.

Folium Artemisiae Argyi, these product are the dried leaves of feverfew Chinese mugwort ArtemisiaargyiLevl.etVant..Pluck when summer, flower was not opened, removing impurity, dries.Cure mainly haematemesis; Epistaxis; Painstaking blood; Have blood in stool; Metrorrhagia; Gestation hemorrhage; Menoxenia; Dysmenorrhea; Frequent fetal movement; Trusted subordinate's cold type of pain; To have loose bowels chronic dysentery; Cramp caused by acute vomiting and diarrhea; Leukorrhagia; Eczema; Scabies; Hemorrhoid; Carbuncle and ulcer.Dispersing cold for relieving pain, warming the meridian for stopping bleeding.For few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile, spit blood, epistaxis, metrorrhagia through many, gestation hemorrhage; External treatment skin pruritus, decortication.Vinegar Chinese mugwort charcoal warming the meridian for stopping bleeding.Hemorrhage for deficient cold type.Compendium of Material Medica carries its blood of regulating the flow of vital energy, by cold-damp; Warming the meridian, hemostasis, antiabortive.Control trusted subordinate's cold type of pain, convulsion of having loose bowels, chronic dysentery, tells nosebleed, hematochezia, menoxenia, metrorrhagia, leukorrhagia, frequent fetal movement, carbuncle and ulcer, scabies.

Fructus Cnidii is pungent, bitter, temperature; Slightly poisonous.Return kidney channel.Cure mainly warming the kidney to invigorate YANG, dampness, dispel the wind, parasite killing.For sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; External treatment vulval eczema, married woman's pudendal pruritus; Eczema scrotum is gynecological external use good medicine." Bencao Jingshu " carries: Fructus Cnidii, and bitter in the mouth is put down; " not Lu " be pungent sweet nontoxic; Modern its abnormal smells from the patient in detail, when warm-dryness syndrome of must holding concurrently, sun also.Therefore swell and ache in housewife people's the moon, man's impotence pruritus due to damp pathogen, except stagnated QI, sharp joint, malignant boil." not Lu " warming the middle warmer and descending qi, makes married woman's Zifu heat, and man is cloudy strong, has made us son.Lid can dehumidify with tongue, and temperature can cold expelling, pungently can moisten kidney, sweet energy strengthening the spleen, therefore can remove all deficiency and coldness of married woman man and to wet disease of viscera connecting with this channel.Cold-damp was both removed, then disease is gone, performance Yiyang, therefore can disease, and had tonification also

Herba Menthae is one of Chinese conventional Chinese medicine.It is pungent cool property sweating antipyretic medicine, controls influenza, the disease such as headache, conjunctival congestion, fever of the body, throat, dental bed swell and ache.External can training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc.Dispelling wind, dispel the heat, ward off dirty, removing toxic substances, affection due to external wind and heat, headache, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria, epidemic febrile disease from the beginning of, rubella pruritus, stagnation of QI due to depression of the liver, hypochondriac pain uncomfortable in chest.Bactericidal action: Mentholum has very strong bactericidal action, d-Mentholum is stronger than the bacteriostasis of 1-Mentholum.Promote Transdermal absorption effect: foreign study shows, menthol significantly can promote the effect of acetaminophen Transdermal absorption, has remarkable penetration enhancement effect to triamcinolone acetonide, the bioavailability of Radix Bupleuri can be made to increase, significantly can promote the Transdermal absorption of acetaminophen.The effect of this promotion Transdermal absorption may be because menthol is by changing the transdermal penetration ability of the structural change medicine of Stratum corneum lipids.

Semen Euryales has the merit of spleen reinforcing antidiarrheal, reinforcing the kindey to control nocturnal emission, is the good medicine of invigorating the spleen to arrest diarrhea, supplementing the kidney to control the nocturnal.The traditional Chinese medical science is thought, the strong then water of spleen is wet, and from going, kidney qi is prosperous, and astringency inducing is had the right, and takes it for a long time, and all diseases are from disappearing.Semen Euryales contains a small amount of starch, a small amount of fatty oil and calcium, phosphorus, ferrum, riboflavin, vitamin C etc.Semen Euryales contains rich in protein, vitamin, mineral and other trace element, ensures composition needed for endotrophic; Semen Euryales can strengthen Small Intestinal, improves urine xylose excretion rate, increases serum concentration of carotene; Experiment proves, the raising of serum carotenoid levels, can make the morbidity risk rate of pulmonary carcinoma, gastric cancer decline, and greatly reduces the chance that cancer occurs.

Embodiment 1: the manufacturing process of washing liquid of the present invention is: by Radix Stemonae 1000g, Cortex Phellodendri 1000g, Radix Sophorae Flavescentis 1000g, Fructus Kochiae 1000g, Cortex Dictamni 1000g, Radix Angelicae Sinensis 1000g, Herba Senecionis Scandentis 1000g, Rhizoma Smilacis Glabrae 1000g, Flos Campsis 1000g, Radix Arnebiae (Radix Lithospermi) 1000g, Herba Leonuri 1000g, Herba Violae 1000g, Caulis Spatholobi 1000g, Fructus Cnidii 1000g, Patrinia scabiosaefolia Fisch grass 1000g, Radix Scutellariae 1000g, Semen Ginkgo 1000g; First described crude drug is ground into coarse powder, then pulverizes further, cross 100 mesh sieves, the enable fine powder amount by 100 mesh sieves is reaching 30%, collects and obtains fine powder a by the fine powder of 100 mesh sieves; Again the coarse powder not by 100 mesh sieves is dropped into multi-function extractor and extract twice, first time adds 8-10 times amount ethanol and decocts 1-2 hour, and second time adds 4-8 times amount soak by water 1-2 hour, merges twice decocting liquid, filters to get filtrate; Heating is concentrated into pasty state, again Herba Menthae 1000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1000g, Semen Euryales 1000g and the Folium Artemisiae Argyi 1000g way of distillation are vaporized into white crystals, be dried to powder, add fine powder a and the coarse granule extracting solution b of preparation, stirring in water bath is even, is mixed into the liquid of thickness, adds in 5% first nitre file solution, stir, tinning after ultraviolet radiation for sterilizing and disinfecting.

Embodiment 2: the manufacturing process of washing liquid of the present invention can also be: by Radix Stemonae 1000g, Cortex Phellodendri 1000g, Radix Sophorae Flavescentis 1000g, Fructus Kochiae 1000g, Cortex Dictamni 1000g, Radix Angelicae Sinensis 1000g, Herba Senecionis Scandentis 1000g, Rhizoma Smilacis Glabrae 1000g, Flos Campsis 1000g, Radix Arnebiae (Radix Lithospermi) 1000g, Herba Leonuri 1000g, Herba Violae 1000g, Caulis Spatholobi 1000g, Fructus Cnidii 1000g, Patrinia scabiosaefolia Fisch grass 1000g, Radix Scutellariae 1000g, Semen Ginkgo 1000g, mixing, chopping, soaks.2 extracting solution each 1 ~ 2 hour, are merged and leave standstill by just soaked crude drug heating and refluxing extraction 2 times.Again the medicinal residues that above-mentioned water extraction is crossed are added 5 ~ 8 times amount 60 ~ 70% alcohol heating reflux and extract 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill.Above-mentioned two kinds of extracting solution are merged, concentrating under reduced pressure relative density is the filtrate of 1.35 (80 DEG C), reclaim ethanol, by gained filtrate adjustment proportion to 1.06, reduce pressure to obtain extractum, by Herba Menthae 1000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1000g, Semen Euryales 1000g and the Folium Artemisiae Argyi 1000g way of distillation are vaporized into white crystalline powder, again by 5% first nitre file solution, 50 DEG C ~ 60 DEG C heating and melting, add the extractum and white powder that prepare, stirring in water bath is even, is mixed into the liquid of thickness, perfusion, uses after ultraviolet radiation for sterilizing and disinfecting.

Embodiment 3: the preparation method of washing liquid of the present invention also can be: Radix Stemonae 1500g, Cortex Phellodendri 1500g, Radix Sophorae Flavescentis 1300g, Fructus Kochiae 1400g, Cortex Dictamni 1200g, Radix Angelicae Sinensis 1300g, Herba Senecionis Scandentis 1400g, Rhizoma Smilacis Glabrae 1400g, Flos Campsis 1400g, Radix Arnebiae (Radix Lithospermi) 1500g, Herba Leonuri 1500g, Herba Violae 1400g, Caulis Spatholobi 1300g, Fructus Cnidii 1400g, Patrinia scabiosaefolia Fisch grass 1400g, Radix Scutellariae 1300g, Semen Ginkgo 1300g, adds the water soaking 1-2 hour of 5-10 times amount, extracts 2 times; Heating extraction 1-2 hour, is concentrated into extractum shape, becomes component 1; Residue medicinal residues add 60-90% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hour, merge extractive liquid, filters, concentrated, 80-160 order filter, 6000-10000 rev/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure relative density is the extractum of 1.35 (80 DEG C), heating and refluxing extraction 2 times, each 30 minutes ~ 45 minutes, extracts active ingredient, 2 extracting solution are merged and is settled into extractum shape, as component 2.Again by Herba Menthae 1300g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1300g, Semen Euryales 1200g and the Folium Artemisiae Argyi 1400g way of distillation are vaporized into white crystalline powder, again by 5% first nitre file solution, 50 DEG C ~ 60 DEG C heating and melting, add the extractum prepared, stirring in water bath is even, be mixed into the liquid of thickness, use after perfusion ultraviolet radiation for sterilizing and disinfecting.

Embodiment 4: get Radix Stemonae 1300g, Cortex Phellodendri 1400g, Radix Sophorae Flavescentis 1300g, Fructus Kochiae 1400g, Cortex Dictamni 1200g, Radix Angelicae Sinensis 1300g, Herba Senecionis Scandentis 1400g, Rhizoma Smilacis Glabrae 1400g, Flos Campsis 1400g, Radix Arnebiae (Radix Lithospermi) 1500g, Herba Leonuri 1500g, Herba Violae 1400g, Caulis Spatholobi 1300g, Fructus Cnidii 1400g, Patrinia scabiosaefolia Fisch grass 1400g, Radix Scutellariae 1300g, Semen Ginkgo 1300g, Herba Menthae 1300g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1300g, Semen Euryales 1200g and Folium Artemisiae Argyi 1400g decocts with water 2 times, collecting decoction, remove sediment, supernatant adds ethanol and filters, filtrate recycling ethanol is to clean, finally be equivalent to 1g crude drug with purified water adjustment medicine liquid volume to every milliliter of medicinal liquid, medicinal liquid is that yellowish-brown is to brown liquid, there is obvious Herba Menthae fragrance.

Treatment takes washout or demibain, each 20 ~ 30mL, every day 2 times.General was 1 course for the treatment of with 10d, observe the curative effect after 2 ~ 3 courses for the treatment of.

Claims (3)

1. prevent and treat the gynecopathy external use cleaning liquid of colpitis mycotica for one kind, it is characterized in that, described washing liquid comprises the crude drug of following parts by weight: the Radix Stemonae 10 ~ 20 parts, Cortex Phellodendri 10 ~ 20 parts, Radix Sophorae Flavescentis 10 ~ 20 parts, the Fructus Kochiae 10 ~ 20 parts, Cortex Dictamni 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Herba Senecionis Scandentis 10 ~ 20 parts, Rhizoma Smilacis Glabrae 10 ~ 20 parts, Flos Campsis 10 ~ 20 parts, Herba Menthae 10 ~ 20 parts, Radix Arnebiae (Radix Lithospermi) 10 ~ 20 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Herba Violae 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Fructus Cnidii 10 ~ 20 parts, Patrinia scabiosaefolia Fisch grass 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Folium Artemisiae Argyi 10 ~ 20 parts, Semen Ginkgo 10 ~ 20 parts, Semen Euryales 10 ~ 20 parts.

2. prevent and treat the gynecopathy external use cleaning liquid of colpitis mycotica according to claim 1, it is characterized in that, in described washing liquid, the parts by weight of various crude drug are: the Radix Stemonae 10 ~ 15 parts, Cortex Phellodendri 10 ~ 15 parts, Radix Sophorae Flavescentis 10 ~ 15 parts, the Fructus Kochiae 10 ~ 15 parts, Cortex Dictamni 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Herba Senecionis Scandentis 10 ~ 15 parts, Rhizoma Smilacis Glabrae 10 ~ 15 parts, Flos Campsis 10 ~ 15 parts, Herba Menthae 10 ~ 15 parts, Radix Arnebiae (Radix Lithospermi) 10 ~ 20 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Herba Violae 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Fructus Cnidii 10 ~ 20 parts, Patrinia scabiosaefolia Fisch grass 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Folium Artemisiae Argyi 10 ~ 20 parts, Semen Ginkgo 10 ~ 20 parts, Semen Euryales 10 ~ 20 parts.

3. prevent and treat the gynecopathy external use cleaning liquid of colpitis mycotica according to claim 1, it is characterized in that, in described washing liquid, the parts by weight of various crude drug are: the Radix Stemonae 10 ~ 20 parts, Cortex Phellodendri 10 ~ 20 parts, Radix Sophorae Flavescentis 10 ~ 20 parts, the Fructus Kochiae 10 ~ 20 parts, Cortex Dictamni 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Herba Senecionis Scandentis 10 ~ 20 parts, Rhizoma Smilacis Glabrae 10 ~ 20 parts, Flos Campsis 10 ~ 20 parts, Herba Menthae 10 ~ 20 parts, Radix Arnebiae (Radix Lithospermi) 10 ~ 15 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, Herba Violae 10 ~ 15 parts, Caulis Spatholobi 10 ~ 15 parts, Fructus Cnidii 10 ~ 15 parts, Patrinia scabiosaefolia Fisch grass 10 ~ 15 parts, Radix Scutellariae 10 ~ 15 parts, Folium Artemisiae Argyi 10 ~ 15 parts, Semen Ginkgo 10 ~ 15 parts, Semen Euryales 10 ~ 15 parts.