CN101811947B - 乙基香兰素生产工艺中减少邻位乙基香兰素生成的方法 - Google Patents
乙基香兰素生产工艺中减少邻位乙基香兰素生成的方法 Download PDFInfo
- Publication number
- CN101811947B CN101811947B CN201010123117.0A CN201010123117A CN101811947B CN 101811947 B CN101811947 B CN 101811947B CN 201010123117 A CN201010123117 A CN 201010123117A CN 101811947 B CN101811947 B CN 101811947B
- Authority
- CN
- China
- Prior art keywords
- vanirone
- reaction
- ethyl vanillin
- thanatol
- drip
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- CBOQJANXLMLOSS-UHFFFAOYSA-N ethyl vanillin Chemical compound CCOC1=CC(C=O)=CC=C1O CBOQJANXLMLOSS-UHFFFAOYSA-N 0.000 title claims abstract description 20
- 238000000034 method Methods 0.000 title claims abstract description 13
- 229940073505 ethyl vanillin Drugs 0.000 title claims abstract description 12
- HHLFWLYXYJOTON-UHFFFAOYSA-N glyoxylic acid Chemical compound OC(=O)C=O HHLFWLYXYJOTON-UHFFFAOYSA-N 0.000 claims abstract description 23
- 238000006243 chemical reaction Methods 0.000 claims abstract description 15
- 238000006482 condensation reaction Methods 0.000 claims abstract description 9
- 238000007254 oxidation reaction Methods 0.000 claims abstract description 7
- 238000009833 condensation Methods 0.000 claims abstract description 6
- 230000005494 condensation Effects 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 18
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 claims description 8
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 6
- 238000013019 agitation Methods 0.000 claims description 6
- 230000003647 oxidation Effects 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 229960003280 cupric chloride Drugs 0.000 claims description 4
- 238000006114 decarboxylation reaction Methods 0.000 claims description 4
- 238000010792 warming Methods 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 2
- 239000012295 chemical reaction liquid Substances 0.000 claims description 2
- 229910000365 copper sulfate Inorganic materials 0.000 claims description 2
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical group [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 2
- 238000004821 distillation Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 239000012074 organic phase Substances 0.000 claims description 2
- 229910052760 oxygen Inorganic materials 0.000 claims description 2
- 239000001301 oxygen Substances 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 239000001117 sulphuric acid Substances 0.000 claims description 2
- 235000011149 sulphuric acid Nutrition 0.000 claims description 2
- 238000005935 nucleophilic addition reaction Methods 0.000 abstract description 11
- 239000003054 catalyst Substances 0.000 abstract description 3
- 229910052751 metal Inorganic materials 0.000 abstract description 3
- 239000002184 metal Substances 0.000 abstract description 3
- 150000003839 salts Chemical class 0.000 abstract description 3
- 238000000926 separation method Methods 0.000 abstract description 2
- 238000000746 purification Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 235000013599 spices Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 241000208125 Nicotiana Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 235000015895 biscuits Nutrition 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- 235000012970 cakes Nutrition 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000834 fixative Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- RUTXIHLAWFEWGM-UHFFFAOYSA-H iron(3+) sulfate Chemical compound [Fe+3].[Fe+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O RUTXIHLAWFEWGM-UHFFFAOYSA-H 0.000 description 1
- 229910000360 iron(III) sulfate Inorganic materials 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201010123117.0A CN101811947B (zh) | 2010-03-12 | 2010-03-12 | 乙基香兰素生产工艺中减少邻位乙基香兰素生成的方法 |
Applications Claiming Priority (1)
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CN201010123117.0A CN101811947B (zh) | 2010-03-12 | 2010-03-12 | 乙基香兰素生产工艺中减少邻位乙基香兰素生成的方法 |
Publications (2)
Publication Number | Publication Date |
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CN101811947A CN101811947A (zh) | 2010-08-25 |
CN101811947B true CN101811947B (zh) | 2014-02-26 |
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CN201010123117.0A Active CN101811947B (zh) | 2010-03-12 | 2010-03-12 | 乙基香兰素生产工艺中减少邻位乙基香兰素生成的方法 |
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CN (1) | CN101811947B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105061174A (zh) * | 2015-08-20 | 2015-11-18 | 辽宁世星药化有限公司 | 一种香兰素的生产方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2734564B1 (fr) * | 1995-05-24 | 1997-07-04 | Rhone Poulenc Chimie | Procede d'hydroxyalkylation d'un ether aromatique |
FR2779718B1 (fr) * | 1998-06-16 | 2000-12-29 | Rhodia Chimie Sa | Procede de preparation de composes p-hydroxymandeliques eventuellement substitues et derives |
CN1401622A (zh) * | 2001-08-23 | 2003-03-12 | 上海家化(集团)有限公司 | 一种由对甲苯酚合成香兰素及其类似物的方法 |
-
2010
- 2010-03-12 CN CN201010123117.0A patent/CN101811947B/zh active Active
Non-Patent Citations (2)
Title |
---|
乙基香兰素的合成;张能芳等;《河北化工》;19901231(第2期);第13-14页 * |
张能芳等.乙基香兰素的合成.《河北化工》.1990,(第2期),第13-14页. |
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Publication number | Publication date |
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CN101811947A (zh) | 2010-08-25 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CB03 | Change of inventor or designer information | ||
CB03 | Change of inventor or designer information |
Inventor after: Ma Xuebing Inventor after: Hong Wei Inventor after: Xiao Linshan Inventor after: Zhao Huawen Inventor after: Wei Yong Inventor after: Tan Xiuwan Inventor before: Ma Xuebing Inventor before: Hong Wei Inventor before: Xiao Linshan Inventor before: Zhao Huawen Inventor before: Wei Yong Inventor before: Tan Xiuwan |
|
CP03 | Change of name, title or address | ||
CP03 | Change of name, title or address |
Address after: 401220 No.2, Huanan No.1 Branch Road, Yanjia chemical industry park, Changshou District, Chongqing Patentee after: Chongqing Xinxin Xiangrong Fine Chemical Co.,Ltd. Address before: No. 2 Huanan 1st Road, Chemical Industry Park, Changshou District, Chongqing, 401221 Patentee before: CHONGQING THRIVE CHEMICAL Co.,Ltd. |