CN101810716A - Preparation method of Chinese pulsatilla root submicron powder at normal temperature - Google Patents
Preparation method of Chinese pulsatilla root submicron powder at normal temperature Download PDFInfo
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Abstract
The invention discloses a preparation method of Chinese pulsatilla root submicron powder at normal temperature. The method comprises the following steps of: selecting the following components in parts by weight: 4 parts of Chinese pulsatilla root, 2 parts of coptis chinensis, 3 parts of golden cypress and 4 parts of ash bark; cleaning and airing; cutting into 3-5cm segments for standby; coarse powder preparation: pulverizing the segmented traditional Chinese medicine tablets and sieving on a sieve of 65 meshes; mixing: uniformly mixing obtained powder; fine powder preparation: pulverizing the mixing powder into fine powder and sieving on a sieve of 100 meshes; and submicron powder preparation: pulverizing the fine powder into submicron powder, wherein the grain size of the powder is 20-40 micrometers. The preparation method is carried out at normal temperature, and low-temperature or special conditions are not needed for preparing; after the raw material medicines are pulverized into the submicron powder, the cell wall-broken rate and the bioavailability are improved, and the pharmacological action is enhanced; the drug dose is reduced, and medicinal materials are saved; the submicron powder can be directly used for drinking water; and the preparation process is simple, the quality standard is controllable, thus the preparation method meets the requirement of mass production.
Description
Technical field
The present invention relates to a kind of veterinary drug, especially relate to the normal temperature preparation method that a kind of veterinary drug Radix Pulsatillae looses.
Background technology
Chinese herbal medicine is the culture rarity of China, and first Shennong's Herbal that the works relevant with natural drug is China put down in writing 365 kinds of natural drugs in the world.China is vast in territory, extend across cold, warm, hot three bands, the resources of medicinal plant that is richly stored with, existing Chinese medicinal herbs kind more than 13000, be wild in the world medicinal plants most species, utilize the earliest, one of country that utilization rate is the highest, accumulating rich experience aspect the utilization Chinese herbal medicine.Chinese herbal medicine is carrying out having the incomparable superiority of other chemical synthetic drugs aspect the prevention and treatment of diseases: safe, toxic and side effects is little, effective ingredient is many, hazard residue is few, action target spot is many, can bring into play combined effect, be difficult for producing drug resistance, scalable immunity of organisms, enhancing body resistance against diseases in anti-bacteria and anti-virus.More and more emphasize food safety in the our times various countries, call under green, the ecological overall background, apply prevention and the control that herbal medicine carries out Animal diseases and be of great practical significance.
The Radix Pulsatillae beginning is stated from and Shennong's Herbal, has the effect of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, removing dampness and killing parasites.The Radix Pulsatillae is the dry root of the ranunculaceae plant Radix Pulsatillae, modern study confirms, the Radix Pulsatillae has antibacterial (Cao Jinghua etc., " time precious traditional Chinese medical science traditional Chinese medicines ", 2003,14 (9): 528), antiviral, the protozoacide effect, remove this and also have human body immunity improving power (Lu Ximing etc., " Gansu college of traditional Chinese medicine journal ", 1998,15 (2): 32), suppress macrophage secretion IL-6, anticancer, antiinflammatory, antidiarrheal, calm, analgesia, suppress bowel movement, the treating endotoxemia isoreactivity is to digestive system, urinary system, multiple disease such as cardiovascular system and hemopoietic system has therapeutical effect preferably.The preparation that 2005 editions " The People's Republic of China's veterinary drug allusion quotation " recorded by Radix Pulsatillae prescription has the Radix Pulsatillae to loose, chicken coccidia powder, chicken dysentery spirit sheet, JILILING SAN, young dysentery is clean, seven granules that relieve internal heat clearly, Bai Long is diffusing etc., be mainly used in the treatment toxic-heat and blood stasis, piglet pujos blancos, the white scour of chicken etc., wherein the Radix Pulsatillae looses and comes from the Radix Pulsatillae decoction prescription of Han dynasty Zhang Zhongjing " Treatise on Febrile and Miscellaneous Disease ", it is at the treatment damp-heat dysentery, toxic-heat and blood stasis has very good effect, but also there are a lot of shortcomings, 1. medicated powder is thick, its particle diameter is the 250-850 micron, 2. using dosage is big, horse, cattle 150-250g, sheep, pig 30-45g, 3. presentation quality and palatability are poor, Rhizoma Coptidis, Cortex Phellodendri has very intensive bitterness, makes animal dislike eating.4. effective ingredient can not fully discharge, and bioavailability is low, has had a strong impact on Chinese medicine quality and therapeutic effect, has restricted application clinically.
Summary of the invention
The object of the present invention is to provide a kind of normal temperature preparation method of rapid-action, curative effect is high, bioavailability is high Chinese pulsatilla root submicron powder.
For achieving the above object, the present invention can take following technical proposals:
The normal temperature preparation method of Chinese pulsatilla root submicron powder of the present invention, it comprises the steps:
The first step, select medicine: choose 4 parts of the Chinese crude drug Radix Pulsatillaes by weight, 2 parts of Rhizoma Coptidis, 3 parts of Cortex Phellodendris, 4 parts of Cortex Fraxinis are cleaned, are dried, and it is standby to cut into the long section of 3-5cm;
Second step, coarse powder: the prepared slices of Chinese crude drugs of cutting are ground into middle powder with bavin field formula pulverizer respectively, cross 65 mesh sieves, powder particle size 180-250 μ m, the powder amount of controlling 80 mesh sieves is no more than 60%;
In the 3rd step, mix: after the preliminary mixing of above-mentioned powder, place trough type mixing machine to mix more than the 0.5h continuously again, obtain mix homogeneously, the mixed powder of color and luster unanimity;
The 4th step, fine powder: the mixed powder of the 3rd step gained is ground into fine powder with universal mill, crosses 100 mesh sieves, powder particle size 100-150 μ m, and the powder amount of crossing 120 mesh sieves is no less than 95%;
In the 5th step, superfine powder: the 4th step gained fine powder is ground into superfine powder with the vibration type super micron mill, and powder particle size 20-40 μ m can obtain the Chinese pulsatilla root submicron powder finished product.
The Chinese pulsatilla root submicron powder finished product of above-mentioned gained is sub-packed in the aluminium foil bag every bag heavy 100g, 200g, 500g, 1000g, 2000g etc.
The invention has the advantages that:
1. whole process of preparation is all carried out at normal temperatures, does not need the preparation of low temperature or specific condition.
2. with after the crude drug micronizing, improve cell wall breaking rate and bioavailability, can strengthen pharmacological action.
3. minimizing dosage is saved medical material, and resource conservation improves abnormal smells from the patient, mouthfeel, improves drug quality, has prolonged storage life.
4. adopt the Chinese pulsatilla root submicron powder of the present invention's preparation, can be directly used in drinking-water and using, changed the instructions of taking that Chinese powder medicine can only spice can not be drunk water.
5. adopt the Chinese pulsatilla root submicron powder of the present invention's preparation, its preparation technology is simple, quality standard is controlled, is fit to the large-scale production demand.
The clinical therapeutic efficacy of preparation of the present invention is verified by following test:
Test drug and material:
Chinese pulsatilla root submicron powder adopts the present invention's preparation.
The LIJUNJING powder; The 100g/ bag, content: 98.5%, prepared in laboratory
The Radix Pulsatillae looses: according to two ones of " Chinese veterinary drug allusion quotation " versions in 2005, manufacture experimently at laboratory.
Swine escherichia coli O
78: China Veterinary Drugs Supervisory Inst. provides.
Experimental animal: 100 of the white commodity piglets of length in 3 ages in week, body weight 10kg ± 5kg, isolated rearing is also fed and is not contained the complete feed of medicine.
The test grouping: experimental animal is divided into 5 groups at random,
The I group adopts the Chinese pulsatilla root submicron powder high-dose therapy, and consumption is a 30g/ days/head;
The II group adopts dosage treatment in the Chinese pulsatilla root submicron powder, and consumption is a 20g/ days/head;
The III group adopts the Chinese pulsatilla root submicron powder low dose therapy, and consumption is a 10g/ days/head.
The IV group adopts the LIJUNJING powder as medicine for treatment, and consumption is 0.5g/kg;
The V group adopts the Radix Pulsatillae to loose, and the treatment consumption is a 30g/ days/head;
The VI group is not treated matched group for counteracting toxic substances.
Test method: with the escherichia coli O that preserves
78Strain is cultivated, and the concentration of measuring bacterium liquid with colony counting method is 6 * 10
9CFU/mL.Except that the blank group, other respectively organizes the counteracting toxic substances amount is every pig intramuscular injection 5mL bacterium liquid.Take the sick pig of clinical onset, make a definite diagnosis infection through laboratory, the test case of being allowed for access is evenly sneaked into trial drug in the feedstuff by above-mentioned variable concentrations and to be fed, logotype 5 days, and therapeutic effect sees Table 1.
Criterion:
Cure: clinical symptoms complete obiteration after the medication treatment, spirit and appetite recover normal for curing;
Produce effects: clinical symptoms obviously alleviates after the medication treatment, and spirit and appetite transfer the treatment produce effects well to;
Effectively: be cure rate and obvious effective rate sum;
Invalid: symptom does not disappear after medication, the state of an illness do not take a turn for the better and treat during because of primary disease death be invalid.
Table 1 variable concentrations Chinese pulsatilla root submicron powder is to the therapeutic effect of piglet pujos blancos
| Group | Cure rate (%) | Obvious effective rate (%) | Effective percentage (%) | Inefficiency (%) |
| ??I | ??96.1 | ??3.9 | ??100 | ??0 |
| ??II | ??90.5 | ??7.8 | ??98.3 | ??4.1 |
| ??III | ??85.4 | ??3.5 | ??88.9 | ??16.1 |
| ??IV | ??69.5 | ??11.6 | ??80.1 | ??19.9 |
| ??V | ??82.0 | ??10.2 | ??92.2 | ??7.8 |
| ??VI | ??- | ??- | ??- | ??88.4 |
Result of the test shows: the Chinese pulsatilla root submicron powder of different treatment consumptions all has the obvious treatment effect to piglet pujos blancos, and the big more effect of consumption is good more, gets therapeutic effect even the therapeutic effect of minimum consumption superfine powder also is better than LIJUNJING.
The specific embodiment
Embodiment 1
The preparation method of Chinese pulsatilla root submicron powder of the present invention, whole process of preparation are all carried out at normal temperatures, and its step is as follows:
The first step, select medicine: choose Chinese crude drug Radix Pulsatillae 6kg, Rhizoma Coptidis 3kg, Cortex Phellodendri 4.5kg, Cortex Fraxini 6kg cleans, dries, and it is standby to cut into the long section of 3-5cm;
Second step, coarse powder: the prepared slices of Chinese crude drugs of cutting are ground into middle powder with bavin field formula pulverizer respectively, cross 65 mesh sieves, powder particle size 180-250 μ m, the powder amount of controlling 80 mesh sieves is no more than 60%;
In the 3rd step, mix: after the preliminary mixing of above-mentioned powder, place trough type mixing machine to mix more than the 0.5h continuously again, obtain mix homogeneously, the mixed powder of color and luster unanimity;
The 4th step, fine powder: the mixed powder of the 3rd step gained is ground into fine powder with universal mill, crosses 100 mesh sieves, powder particle size 100-150 μ m, and the powder amount of crossing 120 mesh sieves is no less than 95%;
In the 5th step, superfine powder: the 4th step gained fine powder is ground into superfine powder with the vibration type super micron mill, and powder particle size 20-40 μ m can obtain the Chinese pulsatilla root submicron powder finished product.
The Chinese pulsatilla root submicron powder finished product of above-mentioned gained is sub-packed in the aluminium foil bag every bag heavy 500g.
Embodiment 2
The preparation method of Chinese pulsatilla root submicron powder of the present invention, whole process of preparation are all carried out at normal temperatures,
Its step is as follows:
The first step, select medicine: choose Chinese crude drug Radix Pulsatillae 12kg, Rhizoma Coptidis 6kg, Cortex Phellodendri 9kg, Cortex Fraxini 12kg cleans, dries, and it is standby to cut into the long section of 3-5cm;
Second step, coarse powder: the prepared slices of Chinese crude drugs of cutting are ground into middle powder with bavin field formula pulverizer respectively, cross 65 mesh sieves, powder particle size 180-250 μ m, the powder amount of controlling 80 mesh sieves is no more than 60%;
In the 3rd step, mix: after the preliminary mixing of above-mentioned powder, place trough type mixing machine to mix more than the 0.5h continuously again, obtain mix homogeneously, the mixed powder of color and luster unanimity;
The 4th step, fine powder: the mixed powder of the 3rd step gained is ground into fine powder with universal mill, crosses 100 mesh sieves, powder particle size 100-150 μ m, and the powder amount of crossing 120 mesh sieves is no less than 95%;
In the 5th step, superfine powder: the 4th step gained fine powder is ground into superfine powder with the vibration type super micron mill, and powder particle size 20-40 μ m can obtain the Chinese pulsatilla root submicron powder finished product.
The Chinese pulsatilla root submicron powder finished product of above-mentioned gained is sub-packed in the aluminium foil bag every bag heavy 1000g.
Claims (1)
1. the normal temperature preparation method of a Chinese pulsatilla root submicron powder, it is characterized in that: it comprises the steps:
The first step, select medicine: choose 4 parts of the Chinese crude drug Radix Pulsatillaes by weight, 2 parts of Rhizoma Coptidis, 3 parts of Cortex Phellodendris, 4 parts of Cortex Fraxinis are cleaned, are dried, and it is standby to cut into the long section of 3-5cm;
Second step, coarse powder: the prepared slices of Chinese crude drugs of cutting are ground into middle powder with bavin field formula pulverizer respectively, cross 65 mesh sieves, powder particle size 180-250 μ m;
In the 3rd step, mix: after the preliminary mixing of above-mentioned powder, place trough type mixing machine to mix more than the 0.5h continuously again, obtain mix homogeneously, the mixed powder of color and luster unanimity;
The 4th step, fine powder: the mixed powder of the 3rd step gained is ground into fine powder with universal mill, crosses 100 mesh sieves, powder particle size 100-150 μ m;
In the 5th step, superfine powder: the 4th step gained fine powder is ground into superfine powder with the vibration type super micron mill, and powder particle size 20-40 μ m can obtain the Chinese pulsatilla root submicron powder finished product.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102028795A (en) * | 2010-12-24 | 2011-04-27 | 北京大北农科技集团股份有限公司 | Chinese pulsatilla root granules for preventing and treating livestock and poultry bacterial diseases and preparation method and premix thereof |
| CN102512509A (en) * | 2011-11-28 | 2012-06-27 | 河南省康星药业有限公司 | Normal-temperature preparation method for ultra-micro fine Chinese pulsatilla powder and special bidirectional airflow sieving machine thereof |
| CN102526302A (en) * | 2011-12-31 | 2012-07-04 | 郑州后羿制药有限公司 | Chinese medicinal micro-ecological preparation for inhibiting piglet bacterial dysentery and preparation method thereof |
| CN104257826A (en) * | 2014-09-24 | 2015-01-07 | 河南亚卫动物药业有限公司 | Traditional Chinese medicine pycnonotus sinensis fermented granule for livestock and poultry and preparation method of traditional Chinese medicine pycnonotus sinensis fermented granule |
| CN109419864A (en) * | 2017-08-22 | 2019-03-05 | 北京中医药大学 | The new application of the Chinese bulbul |
| CN110433264A (en) * | 2019-08-09 | 2019-11-12 | 申亚农牧科技股份有限公司 | A kind of sucking pig nonreactive feed natural additive and preparation method thereof |
| CN112168888A (en) * | 2020-11-12 | 2021-01-05 | 邓云波 | Pure traditional Chinese medicine composition powder for treating bacterial and viral intestinal diseases of livestock and poultry |
-
2009
- 2009-12-17 CN CN200910227508A patent/CN101810716A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102028795A (en) * | 2010-12-24 | 2011-04-27 | 北京大北农科技集团股份有限公司 | Chinese pulsatilla root granules for preventing and treating livestock and poultry bacterial diseases and preparation method and premix thereof |
| CN102512509A (en) * | 2011-11-28 | 2012-06-27 | 河南省康星药业有限公司 | Normal-temperature preparation method for ultra-micro fine Chinese pulsatilla powder and special bidirectional airflow sieving machine thereof |
| CN102512509B (en) * | 2011-11-28 | 2013-08-28 | 河南省康星药业股份有限公司 | Normal-temperature preparation method for ultra-micro fine Chinese pulsatilla powder and special bidirectional airflow sieving machine thereof |
| CN102526302A (en) * | 2011-12-31 | 2012-07-04 | 郑州后羿制药有限公司 | Chinese medicinal micro-ecological preparation for inhibiting piglet bacterial dysentery and preparation method thereof |
| CN104257826A (en) * | 2014-09-24 | 2015-01-07 | 河南亚卫动物药业有限公司 | Traditional Chinese medicine pycnonotus sinensis fermented granule for livestock and poultry and preparation method of traditional Chinese medicine pycnonotus sinensis fermented granule |
| CN109419864A (en) * | 2017-08-22 | 2019-03-05 | 北京中医药大学 | The new application of the Chinese bulbul |
| CN110433264A (en) * | 2019-08-09 | 2019-11-12 | 申亚农牧科技股份有限公司 | A kind of sucking pig nonreactive feed natural additive and preparation method thereof |
| CN112168888A (en) * | 2020-11-12 | 2021-01-05 | 邓云波 | Pure traditional Chinese medicine composition powder for treating bacterial and viral intestinal diseases of livestock and poultry |
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Open date: 20100825 |