CN101810593B - 一种榄香烯缓释片 - Google Patents
一种榄香烯缓释片 Download PDFInfo
- Publication number
- CN101810593B CN101810593B CN201010165908XA CN201010165908A CN101810593B CN 101810593 B CN101810593 B CN 101810593B CN 201010165908X A CN201010165908X A CN 201010165908XA CN 201010165908 A CN201010165908 A CN 201010165908A CN 101810593 B CN101810593 B CN 101810593B
- Authority
- CN
- China
- Prior art keywords
- elemene
- sustained
- release tablets
- microcrystalline cellulose
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
组分 | 微晶纤维素 | 乳糖 | 羧甲基淀粉钠 | 羟丙甲纤维素K-15M | 微粉硅胶 | 8%淀粉水溶液 | β-榄香烯 |
用量/g | 25 | 10 | 2 | 2 | 4 | 3 | 6 |
组分 | 微晶纤维素 | 乳糖 | 羧甲基淀粉钠 | 羟丙甲纤维素K-15M | 微粉硅胶 | 8%淀粉水溶液 | β-榄香烯 |
用量/g | 25 | 10 | 2 | 4.25 | 4.2 | 4 | 6 |
组分 | 微晶纤维素 | 乳糖 | 羧甲基淀粉钠 | 甲基纤维素 | 微粉硅胶 | 8%淀粉水溶液 | β-榄香烯 |
用量/g | 25 | 10 | 2 | 2 | 4 | 3 | 6 |
组分 | 微晶纤维素 | 乳糖 | 羧甲基淀粉钠 | 甲基纤维素 | 微粉硅胶 | 8%淀粉水溶液 | β-榄香烯 |
用量/g | 25 | 10 | 2 | 4.25 | 4 | 4 | 6 |
组分 | 微晶纤维素 | 羧甲基淀粉钠 | 羟丙甲纤维素K-15M | 微粉硅胶 | 8%淀粉水溶液 | β-榄香烯 |
用量/g | 35 | 3.25 | 2 | 4 | 3 | 6 |
组分 | 微晶纤维素 | 羧甲基淀粉钠 | 羟丙甲纤维素K-15M | 微粉硅胶 | 8%淀粉水溶液 | β-榄香烯 |
用量/g | 35 | 3.25 | 4.25 | 4 | 4 | 6 |
组分 | 微晶纤维素 | β-环糊精 | 乳糖 | 羧甲基淀粉钠 | 羟丙甲纤维素K-15M | 微粉硅胶 | 8%淀粉水溶液 | β-榄香烯 |
用量/g | 27.5 | 10 | 15 | 3 | 6.4 | 6 | 6 | 9 |
Claims (7)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201010165908XA CN101810593B (zh) | 2010-05-10 | 2010-05-10 | 一种榄香烯缓释片 |
US13/697,138 US8778417B2 (en) | 2010-05-10 | 2011-04-08 | Anti-tumor plant-medicament sustained-release tablet of elemene |
PCT/CN2011/072530 WO2011140872A1 (zh) | 2010-05-10 | 2011-04-08 | 抗肿瘤植物药榄香烯缓释片 |
EP11780093.8A EP2570121B1 (en) | 2010-05-10 | 2011-04-08 | Slow release tablet of elemene anti-tumor plant medicine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201010165908XA CN101810593B (zh) | 2010-05-10 | 2010-05-10 | 一种榄香烯缓释片 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101810593A CN101810593A (zh) | 2010-08-25 |
CN101810593B true CN101810593B (zh) | 2012-07-18 |
Family
ID=42618056
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201010165908XA Active CN101810593B (zh) | 2010-05-10 | 2010-05-10 | 一种榄香烯缓释片 |
Country Status (4)
Country | Link |
---|---|
US (1) | US8778417B2 (zh) |
EP (1) | EP2570121B1 (zh) |
CN (1) | CN101810593B (zh) |
WO (1) | WO2011140872A1 (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014078435A1 (en) | 2012-11-14 | 2014-05-22 | W. R. Grace & Co.-Conn. | Compositions containing a biologically active material and a non-ordered inorganic oxide |
CN109789095A (zh) * | 2016-07-25 | 2019-05-21 | Ebbu 公司 | 新的***片剂配方和组合物及其制造方法 |
CN114521557B (zh) * | 2021-12-21 | 2023-11-24 | 上海交通大学重庆研究院 | 一种驱鸟缓释剂及其制备方法与应用 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1060038C (zh) | 1993-02-15 | 2001-01-03 | 大连市医药科学研究所 | 榄香烯乳注射液及其制备方法 |
CN1084187C (zh) | 1997-04-14 | 2002-05-08 | 中国远大国际集团有限公司 | 以β-榄香烯为有效成分的抗癌药物的制备方法及其组成 |
CN1080115C (zh) | 1998-08-12 | 2002-03-06 | 大连科宇药业科技开发有限公司 | 榄香烯注射液及其制备方法 |
CN1221607A (zh) | 1998-11-20 | 1999-07-07 | 大连市医药科学研究所 | 脂溶性药物脂质体生产工艺及榄香烯脂质体注射液 |
CN101306181B (zh) | 2002-04-17 | 2011-06-29 | 谢恬 | 榄香烯脂肪乳注射剂及其制备方法 |
CN100374106C (zh) * | 2002-09-18 | 2008-03-12 | 中国远大国际集团有限公司 | 高纯度榄香烯抗癌药物的制备方法 |
CN1241555C (zh) | 2002-12-18 | 2006-02-15 | 上海医药工业研究院 | 榄香烯脂肪乳注射液及制备方法 |
CN1290914C (zh) * | 2002-12-18 | 2006-12-20 | 沈阳市万嘉生物技术研究所 | 榄香烯的羟丙基-β-环糊精包合物及其制剂和制备方法 |
CN1726906A (zh) * | 2004-07-27 | 2006-02-01 | 辽宁卫星制药厂(有限责任公司) | 草酸萘呋胺酯缓释片及其生产方法 |
CN1300071C (zh) | 2004-11-30 | 2007-02-14 | 河北科技大学 | 超临界co2流体萃取-精馏提取莪术中榄香烯的方法 |
CN1303046C (zh) | 2005-04-17 | 2007-03-07 | 仇德安 | 从温郁金中提取β-榄香烯抗癌原料药物的生产工艺 |
CN100560134C (zh) * | 2005-12-29 | 2009-11-18 | 刘玉辉 | 一种榄香烯包合物、其制剂及制备方法 |
CN101125124B (zh) * | 2006-08-16 | 2011-04-20 | 沈阳药科大学 | 一种亲脂性药物固体分散体的制备方法 |
WO2008036932A2 (en) * | 2006-09-21 | 2008-03-27 | Herbalscience Singapore Pte. Ltd. | Compositions and methods comprising boswellia species |
CN101402543A (zh) * | 2008-11-14 | 2009-04-08 | 沈阳万爱普利德医药科技有限公司 | 一种β-榄香烯原料药及其制剂的制备方法 |
CN101461793B (zh) | 2009-01-09 | 2012-06-20 | 四川省中医药科学院 | β-榄香烯脂质体及冻干粉的制备方法 |
-
2010
- 2010-05-10 CN CN201010165908XA patent/CN101810593B/zh active Active
-
2011
- 2011-04-08 US US13/697,138 patent/US8778417B2/en active Active
- 2011-04-08 EP EP11780093.8A patent/EP2570121B1/en active Active
- 2011-04-08 WO PCT/CN2011/072530 patent/WO2011140872A1/zh active Application Filing
Also Published As
Publication number | Publication date |
---|---|
US20130059922A1 (en) | 2013-03-07 |
EP2570121A1 (en) | 2013-03-20 |
CN101810593A (zh) | 2010-08-25 |
EP2570121B1 (en) | 2015-10-14 |
US8778417B2 (en) | 2014-07-15 |
EP2570121A4 (en) | 2014-06-25 |
WO2011140872A1 (zh) | 2011-11-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101810593B (zh) | 一种榄香烯缓释片 | |
CN1706397B (zh) | 具有升高白细胞作用的芍药苷与芍药内酯苷的组合物 | |
CN102085344B (zh) | 一种木香顺气缓释制剂及其制备方法 | |
US20080274215A1 (en) | Composition for treatment of cold and flu | |
CN104771400A (zh) | 一种双乙酰大黄酸和小檗碱的口服药物组合物及其应用 | |
CN101658507B (zh) | 一种愈创木酚甘油醚和伪麻黄碱的复方缓释制剂 | |
CN103211999B (zh) | 一种治疗急慢性肝炎的缓释微丸及其制备方法和应用 | |
CN103301079A (zh) | 一种卡培他滨药物组合物及其制备方法 | |
CN108261435A (zh) | 一种诸葛菜生物碱类提取物及其在制备保肝制品中的应用 | |
CN101543481B (zh) | 一种双层灯盏花素缓释片及制备方法 | |
CN101518519A (zh) | 一种柚皮苷缓释片及其制备方法 | |
CN101744881B (zh) | 包衣材料和致孔剂的混合物在制备中药组合物方面的应用 | |
CN101244068B (zh) | 雪胆素缓释制剂 | |
CN109718226B (zh) | 抗感缓释微丸及其制备方法 | |
CN101780094B (zh) | 雪胆素缓释制剂 | |
CN101829121B (zh) | 雪胆素缓释制剂 | |
CN102258493A (zh) | 红景天苷缓释片及其制备方法 | |
CN1939445B (zh) | 一种枇杷叶水提取物的制备方法与用途 | |
CN102008565A (zh) | 一种治疗溃疡性结肠炎的药物组合物及其制备方法 | |
CN103893368B (zh) | 无糖型仙灵地黄组合物及其颗粒剂和制法 | |
CN104771401A (zh) | 一种双乙酰大黄酸和小檗碱的口服药物组合物 | |
CN105055628A (zh) | 一种治疗性早熟的药物组合物及其应用 | |
CN103315979A (zh) | 一种高乌甲素缓释制剂组合物及其制备方法 | |
CN100553618C (zh) | 一种治疗牙痛的药物 | |
CN102397274A (zh) | 岩白菜素在制备治疗糖尿病药物中的用途 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: XIE TIAN Free format text: FORMER OWNER: HANGZHOU PHARMSUN PHARMACEUTICAL CO., LTD. Effective date: 20120606 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 310012 HANGZHOU, ZHEJIANG PROVINCE TO: 310013 HANGZHOU, ZHEJIANG PROVINCE |
|
TA01 | Transfer of patent application right |
Effective date of registration: 20120606 Address after: Hangzhou City, Zhejiang province 310013 Xihu District Qiushi Road No. 36 Luyuan Ginkgo Garden 3-1902 Applicant after: Xie Tian Address before: 606 room 310012, West Lake building, 202 Wen two road, Zhejiang, Hangzhou, China Applicant before: Hangzhou Pharmsun Pharmaceutical Co., Ltd. |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20100825 Assignee: Dalian Holley Kingkong Pharmaceutical Co., Ltd. Assignor: Xie Tian Contract record no.: 2013210000024 Denomination of invention: Elemene sustained-release tablets Granted publication date: 20120718 License type: Exclusive License Record date: 20130329 |
|
LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
C56 | Change in the name or address of the patentee | ||
CP02 | Change in the address of a patent holder |
Address after: 310013, Hangzhou, Zhejiang Province, Tianmu Road, No. 389, leaving the village 4-1-101 Patentee after: Xie Tian Address before: Hangzhou City, Zhejiang province 310013 Xihu District Qiushi Road No. 36 Luyuan Ginkgo Garden 3-1902 Patentee before: Xie Tian |