CN101810325A - Rhizoma gastrodiae chewable tablet and preparation method thereof - Google Patents
Rhizoma gastrodiae chewable tablet and preparation method thereof Download PDFInfo
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- CN101810325A CN101810325A CN200910078517A CN200910078517A CN101810325A CN 101810325 A CN101810325 A CN 101810325A CN 200910078517 A CN200910078517 A CN 200910078517A CN 200910078517 A CN200910078517 A CN 200910078517A CN 101810325 A CN101810325 A CN 101810325A
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Abstract
The invention relates to a rhizoma gastrodiae chewable tablet and a preparation method thereof. The rhizoma gastrodiae chewable tablet comprises rhizoma gastrodiae used as an active ingredient, and other pharmaceutically acceptable auxiliary materials including fillers, an adhesive, a flavoring agent, a lubricating agent and the like. The invention aims at providing the preparation method of the oral rhizoma gastrodiae chewable tablet which has the advantages of good mouthfeel, convenient taking, quick absorption and quick effect taking and can enhance the bioavailability.
Description
Technical field
The present invention relates to that a kind of mouthfeel is good, taking convenience, absorption be rapid, the preparation method and the application thereof that can improve the oral rhizoma gastrodiae chewable tablet of drug bioavailability, quick acting.
Background technology
Rhizoma Gastrodiae has all given high evaluation in some ancient medicine documents of China.Shennong's Herbal before more than 2000 years is just classified rhizoma Gastrodiae as top grade.The outstanding medical scholar's Li Shizhen (1518-1593 A.D.) of the Ming Dynasty is concluded having done summary about the argumentation of rhizoma Gastrodiae effect in the successive dynasties books in Compendium of Material Medica: and rhizoma Gastrodiae " suffering, temperature, nontoxic.The beneficial strength of clothes is long cloudy for a long time, and is fertile strong, makes light of one's life by commiting suicide, and increases year.It is too fat to move to disappear, and lower limb are full, blood under the cold hernia.Cure mainly rheumatism, spasm of limbs, it is unsuccessful to paralyse; Children's's wind pain, frightened gas, aid yang qi is mended five earth sevens kinds of impairments; The empty dizziness and headache of wind, promoting blood circulation is had one's ideas straightened out.Take Wuji etc. ".
In China, the history that rhizoma Gastrodiae was used as medicine existing more than 1000 year.Its drug effect has: 1. analgesic activity: the rhizoma Gastrodiae parenteral solution with rhizoma Gastrodiae is made to trigeminal neuralgia, angioneurotic headache, cerebrovascular disease headache, toxic polyneuritis etc., has tangible analgesic effect.In recent years, through some 1000 many cases patients' of medical institutions clinic trial, efficiently reach 90%.2. sedation: the medical institutions that have are with synthetic Gastrodin (gastrodin) treatment neurasthenia and neurasthenia syndrome patient, efficiently are respectively 89.44% and 86.87%.And can suppress the central excitation effect due to the caffeine, strengthen the effect length of one's sleep of carbrital in addition.3. anticonvulsant action: rhizoma Gastrodiae is to the certain curative effect of facial nerve tics, extremity numbness, hemiplegia, epilepsy etc.Alleviate smooth muscle spasm in addition, the effect of allevating angina pectoris, cholecystalgia.4. effect brings high blood pressure down: rhizoma Gastrodiae can be treated hypertension.For a long time clothes can flat liver benefit gas, sharp waist knee, strengthening the bones and muscles, also can increase periphery and crown blood flow volume, heart is had protective effect.5. make eye bright, increase the intelligence effect: rhizoma Gastrodiae still has the effect that makes eye bright and significantly strengthen memory.Rhizoma Gastrodiae has significant protection and regulating action to people's cerebral nervous system, can strengthen the resolution capability of optic nerve, is used as high-altitude flight personnel's brain health food or brain health medicine at present.Japan is with rhizoma Gastrodiae injection for treating senile dementia, efficiently reaches 81%.
The pharmaceutical preparation that contains rhizoma Gastrodiae at present is mainly capsule and conventional tablet, because the limitation of its formulation, drug absorption is slower rapidly, and bioavilability is lower, can not reach desirable result of treatment.
Summary of the invention
The purpose of this invention is to provide that a kind of mouthfeel is good, taking convenience, absorption be rapid, the preparation method and the application thereof that can improve the rhizoma Gastrodiae oral taking chewy sheet of drug bioavailability, quick acting.
Rhizoma gastrodiae chewable tablet of the present invention also contains auxiliary material except the main ingredient rhizoma Gastrodiae.Auxiliary material can comprise filler, adhesive, flavouring, lubricant etc., can also add an amount of pigment in case of necessity.In each preparation unit, drug ingedient is a rhizoma Gastrodiae, and content is 0.25～1.5g in the unit formulation, is preferably 0.25～1.0g, more preferably 0.5g.
Owing to chewable tablets requirement good mouthfeel, to the oral mucosa nonirritant.Therefore extremely important to the selection of supplementary product kind and performance thereof.
The present invention has found the pharmaceutic adjuvant of chewable tablets of the present invention through selecting, and filler includes but are not limited to any one or the mixture in starch, microcrystalline cellulose, sucrose, glucose, lactose, dextrin, sweet mellow wine, sorbierite, the xylitol etc.; Adhesive includes but are not limited to a kind of or its mixture in water, water/alcoholic solution, starch slurry, polyvinylpyrrolidone, methylcellulose, ethyl cellulose, Hydroxypropyl methylcellulose, L-HPC, hydroxyethylcellulose, sodium carboxymethylcellulose, sugar aqueous solution, honey solution, xanthans, Arabic gum, alginic acid and its esters etc.; Flavouring one of includes but are not limited in vanilla, cherry, grape, orange, lemon, peppermint, strawberry, banana, pineapple, honey peach essence, maltitol, saccharin sodium, albumen sugar, sucrose, Aspartame, stevioside, Sucralose, the acesulfame-K or wherein several mixtures; Lubricant includes but are not limited to one or more in superfine silica gel powder, dolomol, talcum powder, polyethylene glycol, leucine, the sodium stearyl fumarate etc.; Can also add an amount of colouring agent therein in case of necessity, colouring agent includes but not limited to as sunset yellow, famille rose, curcumin, light green etc.
Rhizoma gastrodiae chewable tablet of the present invention, its preparation method can adopt compressing tablet behind direct powder compression and the wet granulation.Adopt direct powder compression, for flowability, the compressibility of material higher requirement is arranged, therefore the selection for material has higher requirement.
Rhizoma gastrodiae chewable tablet of the present invention when adopting the wet granulation process compressing tablet, can carry out according to conventional formulation technology.
Rhizoma gastrodiae chewable tablet of the present invention can be used for multiple diseases such as the treatment headache is dizzy, extremity numbness, epilepsy clonus.
The specific embodiment
Come rhizoma gastrodiae chewable tablet of the present invention done further specifying by following example, but be not limited in following example.
Embodiment 1
Prescription:
The preparation method:
1. rhizoma Gastrodiae is pulverized, crossed 80 mesh sieves, all the other above all solids supplementary materials are crossed 65 mesh sieves, and are standby;
2. after getting recipe quantity rhizoma Gastrodiae and sorbierite and mixing, add purified water and make softwood .16 mesh sieve in right amount and granulate, 70 ℃ of dryings, the whole grain of 16 mesh sieves, standby;
3. in above particle, add flavoring orange essence, carry out behind Sucralose, the dolomol always mixing, compressing tablet is made 1000 altogether.
Embodiment 2
Prescription:
The preparation method:
1. get rhizoma Gastrodiae and pulverize, cross 80 mesh sieves, add sucrose solution, the system softwood, 16 orders are granulated, 70 ℃ of dryings, the whole grain of 16 mesh sieves, standby.
2. the composition granule of getting it filled adds dolomol, lemon extract, aspartame and pregelatinized starch and mixes.
3. after mixing, adjustment sheet heavily reaches pressure, and direct powder compression is made 1000 altogether.
Embodiment 3
Prescription:
The preparation method:
1. rhizoma Gastrodiae is pulverized, crossed 80 mesh sieves, add HPMC solution system softwood, 16 orders are granulated, 70 ℃ of dryings, and the whole grain of 16 mesh sieves, standby.
2. get it filled composition granule and other auxiliary materials mixes.
3. adjustment sheet heavily reaches pressure and is pressed into 1000.
Embodiment 4
Prescription:
The preparation method:
1. rhizoma Gastrodiae is pulverized, crossed 80 mesh sieves, all the other above all solids supplementary materials are crossed 65 mesh sieves, and are standby;
2. after getting recipe quantity rhizoma Gastrodiae and sweet mellow wine and mixing, 50% syrup is as adhesive, and add this solution and make softwood .16 mesh sieve in right amount and granulate, 60 ℃ of dryings, the whole grain of 16 mesh sieves, standby;
3. with above particle, add Aspartame, lemon extract, dolomol, always be mixed even after, adjustment sheet heavily reaches pressure, compressing tablet is pressed into 1000 altogether.
Embodiment 5
Prescription:
The preparation method:
1. rhizoma Gastrodiae is pulverized, crossed 80 mesh sieves, all the other above all solids supplementary materials are crossed 65 mesh sieves, and are standby;
2. after getting recipe quantity rhizoma Gastrodiae and xylitol and mixing, add 50% syrup, add this solution and make softwood .16 mesh sieve in right amount and granulate as adhesive, 60 ℃ of dryings, the whole grain of 16 mesh sieves, standby;
3. with above particle, add other residue auxiliary material, always be mixed even after, adjustment sheet heavily reaches pressure, is pressed into 1000.
Embodiment 6
Prescription:
The preparation method:
1. rhizoma Gastrodiae is pulverized, crossed 80 mesh sieves, all the other above all solids supplementary materials are crossed 65 mesh sieves, and are standby;
2. after getting recipe quantity rhizoma Gastrodiae and xylitol, sweet mellow wine and mixing, as adhesive, add this solution and make softwood .16 mesh sieve in right amount and granulate with 50% syrup, 60 ℃ of dryings, the whole grain of 16 mesh sieves, standby;
3. with above particle, add essence and dolomol, always be mixed even after, adjustment sheet heavily reaches pressure, is pressed into 1000 altogether.
Embodiment 7
Prescription:
The preparation method:
1. rhizoma Gastrodiae is pulverized, crossed 80 mesh sieves, all the other above all solids supplementary materials are crossed 65 mesh sieves, and are standby;
2. get after recipe quantity Rhizoma Gastrodiae powder and pregelatinized starch, lactose and aspartame mix, as adhesive, add this solution and make softwood .16 mesh sieve in right amount and granulate with 10% PVP ethyl ketone solution, 60 ℃ of dryings, the whole grain of 16 mesh sieves, standby;
3. with above particle, add silica, always be mixed even after, adjustment sheet heavily reaches pressure, is pressed into 1000 altogether.
Embodiment 8
Prescription:
The preparation method:
1. rhizoma Gastrodiae is pulverized, crossed 80 mesh sieves, all the other above all solids supplementary materials are crossed 65 mesh sieves, and are standby;
2. get after recipe quantity Rhizoma Gastrodiae powder and pregelatinized starch, lactose and aspartame mix, as adhesive, add this solution and make softwood .16 mesh sieve in right amount and granulate with 10% PVP ethyl ketone solution, 60 ℃ of dryings, the whole grain of 16 mesh sieves, standby;
3. with above particle, add dolomol, always be mixed even after, adjustment sheet heavily reaches pressure, is pressed into 1000 altogether.
Claims (7)
1. a chewable tablet is characterized in that: be traditional Chinese medicine ingredients with the rhizoma Gastrodiae, also include other acceptable accessories, include but not limited to filler, adhesive, flavouring, lubricant etc.
2. chewable tablet as claimed in claim 1 is characterized in that: the consumption of rhizoma Gastrodiae is 0.25～1.5g in the unit formulation, is preferably 0.25～0.5g, more preferably 0.5g.
3. chewable tablet as claimed in claim 1 is characterized in that: described filler includes but are not limited to any one or the mixture in starch, pregelatinized starch, gelling starch, microcrystalline cellulose, sucrose, glucose, lactose, dextrin, sweet mellow wine, sorbierite, xylitol, the beta cyclodextrin etc.
4. chewable tablet as claimed in claim 1 is characterized in that: described adhesive includes but are not limited to a kind of or its mixture in water, water/alcoholic solution, starch slurry, polyvinylpyrrolidone, methylcellulose, ethyl cellulose, Hydroxypropyl methylcellulose, L-HPC, hydroxyethylcellulose, sodium carboxymethylcellulose, sugar aqueous solution, honey solution, xanthans, Arabic gum, alginic acid and its esters etc.
5. chewable tablet as claimed in claim 1 is characterized in that: described flavouring one of includes but are not limited in vanilla, cherry, grape, orange, lemon, peppermint, strawberry, banana, pineapple, honey peach essence, maltitol, saccharin sodium, albumen sugar, sucrose, Aspartame, stevioside, acesulfame-K, the Sucralose or wherein several mixtures.Can also add an amount of colouring agent therein in case of necessity, as sunset yellow, famille rose, curcumin, light green etc.
6. chewable tablet as claimed in claim 1 is characterized in that: described lubricant includes but are not limited to one or more in superfine silica gel powder, dolomol, talcum powder, polyethylene glycol, leucine, the sodium stearyl fumarate etc.
7. the preparation method of chewable tablet as claimed in claim 1 is characterized in that: can adopt compressing tablet behind direct powder compression and the wet granulation.
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| Application Number | Priority Date | Filing Date | Title |
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| CN200910078517A CN101810325A (en) | 2009-02-25 | 2009-02-25 | Rhizoma gastrodiae chewable tablet and preparation method thereof |
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| CN200910078517A CN101810325A (en) | 2009-02-25 | 2009-02-25 | Rhizoma gastrodiae chewable tablet and preparation method thereof |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102805346A (en) * | 2012-08-22 | 2012-12-05 | 侯卫亭 | Kardiseed chewable tablet and preparation process thereof |
| CN102813111A (en) * | 2012-05-08 | 2012-12-12 | 陕西恒康生物科技有限公司 | Cane sugar-free functional fruit paste containing gastrodia tuer and preparation method of fruit paste |
| CN103005434A (en) * | 2012-12-06 | 2013-04-03 | 四川锡成天然食品有限公司 | Freeze-dried gastrodia elata chewable tablet manufacturing method |
| CN103053777A (en) * | 2012-12-31 | 2013-04-24 | 华南农业大学 | Preserved plum powder tabletting candy produced by directly tabletting complete powder, and preparation method |
| CN103798574A (en) * | 2012-11-05 | 2014-05-21 | 安徽科技学院 | Chuzhou chrysanthemum chewable tablet |
| CN106615538A (en) * | 2016-10-19 | 2017-05-10 | 昭通市天麻研究院 | Gastrodia elata buccal tablets and preparation method thereof |
| CN108783448A (en) * | 2018-07-01 | 2018-11-13 | 甘肃农业大学 | A kind of Herba Cistanches Rhizoma Gastrodiae Composite Chew slice prescription and preparation method |
| CN108783447A (en) * | 2018-07-01 | 2018-11-13 | 甘肃农业大学 | A kind of quinoa rhizoma gastrodiae chewable tablet and preparation method thereof |
| CN109938335A (en) * | 2019-04-04 | 2019-06-28 | 西北师范大学 | A kind of Rhizoma Gastrodiae cynomorium songaricum chewable tablets and preparation method thereof |
| CN113171429A (en) * | 2021-04-14 | 2021-07-27 | 大方县九龙天麻开发有限公司 | Gastrodia elata tablets and preparation method thereof |
-
2009
- 2009-02-25 CN CN200910078517A patent/CN101810325A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102813111A (en) * | 2012-05-08 | 2012-12-12 | 陕西恒康生物科技有限公司 | Cane sugar-free functional fruit paste containing gastrodia tuer and preparation method of fruit paste |
| CN102805346A (en) * | 2012-08-22 | 2012-12-05 | 侯卫亭 | Kardiseed chewable tablet and preparation process thereof |
| CN102805346B (en) * | 2012-08-22 | 2014-01-29 | 侯卫亭 | Kardiseed chewable tablet and preparation process thereof |
| CN103798574A (en) * | 2012-11-05 | 2014-05-21 | 安徽科技学院 | Chuzhou chrysanthemum chewable tablet |
| CN103005434A (en) * | 2012-12-06 | 2013-04-03 | 四川锡成天然食品有限公司 | Freeze-dried gastrodia elata chewable tablet manufacturing method |
| CN103053777A (en) * | 2012-12-31 | 2013-04-24 | 华南农业大学 | Preserved plum powder tabletting candy produced by directly tabletting complete powder, and preparation method |
| CN106615538A (en) * | 2016-10-19 | 2017-05-10 | 昭通市天麻研究院 | Gastrodia elata buccal tablets and preparation method thereof |
| CN108783448A (en) * | 2018-07-01 | 2018-11-13 | 甘肃农业大学 | A kind of Herba Cistanches Rhizoma Gastrodiae Composite Chew slice prescription and preparation method |
| CN108783447A (en) * | 2018-07-01 | 2018-11-13 | 甘肃农业大学 | A kind of quinoa rhizoma gastrodiae chewable tablet and preparation method thereof |
| CN109938335A (en) * | 2019-04-04 | 2019-06-28 | 西北师范大学 | A kind of Rhizoma Gastrodiae cynomorium songaricum chewable tablets and preparation method thereof |
| CN113171429A (en) * | 2021-04-14 | 2021-07-27 | 大方县九龙天麻开发有限公司 | Gastrodia elata tablets and preparation method thereof |
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Application publication date: 20100825 |