CN101703568B - Medicament for preventing and treating hepatitis B and preparation method thereof - Google Patents
Medicament for preventing and treating hepatitis B and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a medicament for preventing and treating hepatitis B and a preparation method thereof. The medicament consists of a first party and a second party. The first party is prepared from the following raw materials by mass: 120g to 180g of lightyellow sophora root, 80g to 120g of radix berberidis, and 30g to 70g of indigowoad root. The second party is prepared from the following raw materials by mass: 5g to 30g of Chinese magnoliavine fruit, 45g to 75g of Chinese aralia bark and root-bark, 30g to 50g of virgate wormwood herb, 30g to 60g of gynostemma pentaphyllum, 45g to 150g of radix astragali seu hedysari, 30g to 60g of glossy ganoderma, 45g to 75g of cassia seed, 30g to 60g of boxthorn and 30g to 75g of Chinese date. The medicament for preventing and treating the hepatitis B overcomes the defects of the conventional therapeutic medicament, has effects on strengthening the immunity, smoothing the liver, protecting the gallbladder, inhibiting virus replication, killing harmful bacteria and the like, and not only has short treatment period and good treatment effect, but also has low price without obvious toxic and side effects by clinical application. The medicament of the present invention can be used as an essential medicament for preventing and treating the hepatitis B. The medicament can be prepared into medicinal granules, capsules or troches, and can be taken conveniently.
Description
Technical field:
The present invention relates to medicine of a kind of prevention and treatment hepatitis B and preparation method thereof.
Background technology:
Hepatitis B is a kind of commonly encountered diseases and frequently-occurring disease, in China hepatitis B virus (HBV) the infected 1.5 hundred million is arranged approximately, about 3000---4000 ten thousand people of patient that wherein need smelting to treat.These patients are owing to be subjected to the infection of HBV for a long time, the dysfunction of exempting from service, and hepatic fibrosis constantly increases the weight of, the trend of oriented liver cirrhosis and primary hepatocarcinoma development.The treatment of chronic viral hepatitis B now, still be one very thorny, very difficult task.The medicine of treatment hepatitis B is a lot of at present, but these medicines are because problems such as curative effect, price and untoward reaction make its clinical practice be subjected to certain limitation.
Summary of the invention:
The technical problem that the present invention solves: medicine of a kind of prevention and treatment hepatitis B and preparation method thereof is provided, overcome the deficiency of existing medicine, have to strengthen and exempt from service, soothing liver-QI protects gallbladder, suppress virus replication, effects such as killing pathogenic bacteria are through clinical practice not only short treating period, good effect, and cheap, there is not obviously poison pair effect.Can be used as the essential drugs of prevention, treatment hepatitis B.The present invention can be made into electuary, capsule or tablet, taking convenience.
Technical scheme of the present invention is: the present invention is made up of Party A and Party B, and the Party A is made by inhibition virus, the eliminating evil class Chinese herbal medicine Radix Sophorae Flavescentis of killing pathogenic bacteria, Radix Berberidis, Radix Isatidis; The Party B is made by set upright the class Chinese herbal medicine Fructus Schisandrae Chinensis, Cortex Araliae Chinensis, Herba Artemisiae Scopariae, Herb Gynostemmae Pentaphylli, the Radix Astragali, Ganoderma, Semen Cassiae, Fructus Lycii, Fructus Jujubae of the gallbladder hepatoprotective that relaxes, raise immunity; Party A, Party B's crude drug extracted respectively be processed into electuary, capsule or tablet.
Radix Sophorae Flavescentis is the dry root of leguminous plant Radix Sophorae Flavescentis Sophora Flavescens Ait, has heat-clearing and toxic substances removing, an effect such as the arresting lacrimation that makes eye bright, dampness diuresis, wind dispelling insecticide, settling five organs, the sedate of making light of one's life by commiting suicide.Alkaloid in the Radix Sophorae Flavescentis has multiple physiologically active, through evidence, matrine has the tool anti-HBV effect, also stronger to virus functions such as RSV, CB, ORV, adv, interferon is the most important lymphokine of body antagonism viral infection, have broad-spectrum antiviral and immunoregulation effect, Radix Sophorae Flavescentis alkaloid can induce the alpha-interferon that people-leukocyte produces, and is the principal element of its viral infection resisting.Simultaneously, Radix Sophorae Flavescentis and effective ingredient thereof can anti-HBV and HCV, improve hepatocyte function, anti-apoptotic.
Radix Berberidis is the dry root that the Berberidaceae plant is intended porcupine quill Berbens soulieana schneia, has the function of heat clearing and damp drying, eliminating fire and detoxication.Root contains quaternary amines alkaloid etc.On pharmacology, have effects such as antibiotic, blood pressure lowering, function of gallbladder promoting, rising leukocyte, active anticancer.
Radix Isatidis is the root of crucifer ancient name for Chinese cabbage basket Isatis indigotica Fort, has the effect of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.Main chemical compositions is organic acid chemical compound, alkaloid compound and other types alkaloid.Being used for multiple treatment of diseases such as mumps, meningitis, pink eye disease, laryngitis, hepatitis clinically, is the antipyretic and antidotal type Chinese medicine of using always.The pharmacological action of heat and toxic materials clearing away medicine is quite extensive, can eliminate by antibiotic, antiviral, antitoxin and pass or eliminate the pathogenic factor of having invaded internal organs in the pathogenic factor; By analgesic, antiinflammatory, antiallergic relief of symptoms; Promote immunologic function by the content that improves antibiotic substance in the body, strengthen the reparation of intravital resistance against diseases and promotion tissue injury.Modern pharmacology research mainly concentrates on effect of direct destruction bacterial endotoxin and resisting pathogenic microbes effect to the explanation of Radix Isatidis antipyretic and antidote functions.
Fructus Schisandrae Chinensis is the dry mature fruit of magnoliaceae schisandra Schisandra Chinensis (Turcz.) Baill.Effect with astringent or styptic treatment for spontaneous sweating, the supplementing QI for promoting the production of body fluid of convergence, kidney calming.Contain lignanoid, the volatilization fat-soluble chemical constituent of wet goods and multiple water-soluble chemical components such as organic acid, vitamin and polysaccharide in the Fructus Schisandrae Chinensis.Fructus Schisandrae Chinensis is mainly used in the control of hepatopathy, and its SGPT that causes hepatic injury to cause to carbon tetrachloride, thiacetic acid. amine etc. raises the reduction effect is all arranged; The high SGPT of hepatitis is reduced, also can alleviate the substance metabolism obstacle of poisoning hepatic injury, have slight rising liver glycogen, alleviate hepatocellular degeneration, alleviate the poisoning virulence factor, the synthetic effect of the hepatocyte internal protein of promotion is arranged liver cell mitochondria and lysosomal destruction.
Cortex araliae chinensis is five to add the Aralia fogfruit Cortex araliae chinensis Aralia chinensis L. of section, is used as medicine with root bark and peel of stem.Has expelling wind and removing dampness, inducing diuresis to remove edema, effects such as promoting blood circulation and stopping pain.Be mainly used in hepatitis, lymphadenectasis, oedema due to nephritis, diabetes, leucorrhea, stomachache, rheumatic arthritis, lumbago and skelalgia, treatments such as traumatic injury.Peel of stem and root bark contain triterpenoid saponin (being mainly oleanolic acid), tannin, choline, volatile oil.Oleanolic acid has hepatoprotective and falls enzyme, promotes effects such as liver cell regeneration, antiinflammatory, heart tonifying, diuresis, antitumor also have blood sugar lowering, blood fat reducing, abirritative effect, is the effective ingredient of medicines such as exploitation treatment hepatopathy and blood sugar lowering.
Herba Artemisiae Scopariae is the seedling of feverfew Herba Artemisiae Scopariae Artemisia capillaris Thunb..Have function of gallbladder promoting, protect the liver, resisting pathogenic microbes, analgesic, bring down a fever, diuresis, anticoagulation, fibrinolysis enhancing, blood fat reducing, antitumor action.Be used for the treatment of jaundice oliguria, eczema pruritus, infectious jaundice type hepatitis etc.
Herb Gynostemmae Pentaphylli is the herb of cucurbitaceous plant Herb Gynostemmae Pentaphylli Gynostemma pentaphyllum (Thunb.) Mak..The Herb Gynostemmae Pentaphylli crude drug in whole contains 83 kinds of gypenosides, and its total saponin content is 3 times of Korean Ginseng.Herb Gynostemmae Pentaphylli can be improved liver function, suppresses the rising that ammonia ferment (SGOT) and alanine commentaries on classics ammonia ferment (SGPT) value are changeed in the acid of Radix Asparagi radon.Hepatocellular degeneration, necrosis etc. all there is significant protective effect, and can promotes liver cell regeneration.
Radix Astragali this product is the dry root of leguminous plant Radix Astagali Astragalus membranaceus.Have the organism metabolism of promotion, resisting fatigue, promotion serum and the proteinic regeneration function of liver; Can strengthen and the adjusting body's immunity, interferon system is had facilitation, improve the premunition of body; Viral institute cytopathogenic effect there are slight inhibitory action, antibacterial action and effect such as protect the liver widely.
Semen Cassiae is the mature seed of leguminous plant Semen Cassiae Cassia tora.Has liver heat removing and eyesight improving, the effect of diuretic relieving constipation.Can be used for treating hepatitis, cirrhotic ascites.
Ganoderma is Polyporaceae fungus Ganoderma lucidum (Leyss. Ex Fr.) Karst. Ganoderma lucidum (Leyss.ex Fr.) Karst. or Ganoderma Gano-derma sinense Zhao, the dry sporophore of Xu et Zhang.Have strengthening the body resistance, raise immunity improves effects such as Abwehrkraft des Koepers.Ganoderma has dual regulation to human body, and is very remarkable to the preventive and therapeutic effect of tumor, hepatic lesions, insomnia and aging.Two-ways regulation function of human body balance is transferred the internal body vigor on the whole, regulates human body metabolism function, improves the autoimmune ability, impels internal organs and organ function normalization.
Fructus Lycii is the mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..Have immunologic enhancement and immunoregulation effect, can improve plasma testosterone level, hemopoietic function is had facilitation; Normal healthy people also there is the effect of remarkable promoting leucocytes; Also have defying age, mutation, antitumor, blood fat reducing, protect the liver and anti-fatty liver, blood sugar lowering, hypotensive activity.
Fructus Jujubae is the dry mature fruit of Rhamnaceae jujube Fructus Jujubae Ziziphus jujuba Mill.var.inermis (Bunge) Rehd..Have effects such as tonify deficiency QI invigorating, nourishing blood to tranquillize the mind, invigorating the spleen and regulating the stomach.Diseases such as chronic hepatitis, liver cirrhosis, anemia, anaphylactoid purpura there is better curative effect.
Party A of the present invention is made by the raw material of following weight ratio: Radix Sophorae Flavescentis 120-180, Radix Berberidis 80-120, Radix Isatidis 30-70; Be monarch drug altogether with Radix Sophorae Flavescentis, Radix Berberidis, three kinds of Chinese herbal medicine of Radix Isatidis among the Party A.Three medicines are played antiviral and the effect of the pathogenic bacteria of going out altogether for monarch.
Party B of the present invention is made by the raw material of following weight ratio: Fructus Schisandrae Chinensis 5-30, Cortex Araliae Chinensis root bark 45-75, Herba Artemisiae Scopariae 30-50, Herb Gynostemmae Pentaphylli 30-60, Radix Astragali 45-150, Ganoderma 30-60, Semen Cassiae 45-75, Fructus Lycii 30-60, Fructus Jujubae 30-75.Be ministerial drug with Fructus Schisandrae Chinensis, Cortex Araliae Chinensis, Herba Artemisiae Scopariae among the Party B.The mastery reaction of this prescription ministerial drug falls enzyme and turns out cloudy for the gallbladder hepatoprotective that relaxes.With Herb Gynostemmae Pentaphylli, the Radix Astragali, Ganoderma, Semen Cassiae, Fructus Lycii, Fructus Jujubae Six-element medicine is adjuvant drug, and the mastery reaction of this prescription adjuvant drug is to strengthen to exempt from service, and adjusts function, the balance property of medicine.Full side is gentle not high, mends and lets out and execute, giving consideration to both the incidental and fundamental.
Party A's preparation method: get by weight ratio and add suitable quantity of water behind the crude drug mixing and boil and make medicinal liquid one time, adding for the second time suitable quantity of water boils and makes the secondary medicinal liquid, adding suitable quantity of water for the third time boils and makes medicinal liquid three times, medicinal liquid, secondary medicinal liquid and three medicinal liquids are merged the filtration final vacuum be concentrated into sticking cream, to glue the cream cold drying and make dry powder, will load capsule behind the dry powder sterilization.
Party B's preparation method: get the crude drug mixing by weight ratio and add earlier an amount of ethanol and heat and make medicinal liquid one time, will be concentrated into sticking cream behind the medical filtration, will glue the cream cold drying and make alcohol extraction dry powder to 70 ℃ of reflux, extract; Adding for the second time suitable quantity of water heats and extracts and reclaim ethanol to about 90 ℃ and make the secondary medicinal liquid; Add suitable quantity of water for the third time and boil to extract and make medicinal liquid three times, secondary medicinal liquid, three medicinal liquids are merged filter final vacuums and be concentrated into sticking cream, will glue the cream cold drying and make water and promote powder; Sterilization behind merging alcohol extraction dry powder and the water promotion powder is loaded capsule.
The present invention has overcome the deficiency of existing medicine, has to strengthen to exempt from service, and soothing liver-QI protects gallbladder, suppresses virus replication, and effects such as killing pathogenic bacteria through clinical practice not only short treating period, good effect, and cheap, do not have obviously poison and pay effect.Can be used as the essential drugs of prevention, treatment hepatitis B.The present invention can be made into electuary, capsule or tablet, taking convenience.
The specific embodiment:
Embodiment one:
1, Party A's crude drug weight proportion: Radix Sophorae Flavescentis 120g, Radix Berberidis 80g, Radix Isatidis 30g;
2, Party A's preparation method: add to extract irritate after by above-mentioned weight proportion, add 1000 milliliters of drinking waters for the first time the crude drug mixing, boil 20 minutes after, emit and make medicinal liquid one time.For the second time add 800 milliliters of drinking waters, boil 10 minutes after, emit and make the secondary medicinal liquid.Add 700 milliliters of drinking waters for the third time, boil 10 minutes after, emit and make medicinal liquid three times.Medicinal liquid, secondary medicinal liquid and three medicinal liquids are merged the filtration final vacuum concentrate, dry powder is made in cold drying, will load capsule behind the dry powder sterilization, every 0.5g of capsule.
3, Party B's crude drug weight proportion: Fructus Schisandrae Chinensis 15g, Cortex Araliae Chinensis root bark 45g, Herba Artemisiae Scopariae 30g, Herb Gynostemmae Pentaphylli 30g, Radix Astragali 45g, Ganoderma 30g, Semen Cassiae 45g, Fructus Lycii 30g, Fructus Jujubae (enucleation) 30g.
4, Party B's preparation method: add to extract irritate after with the crude drug mixing by above-mentioned weight proportion, adding for the first time ethanol soaks into for 1500 milliliters and heated in 2 hours to 70 ℃ of left and right sides reflux, extract, after 40 minutes, emit and make medicinal liquid one time, alcohol extraction dry powder is made in cold drying after being concentrated into sticking cream behind the medical filtration.For the second time add 1000 milliliters of drinking waters, heat to about 90 ℃ and extract and reclaimed ethanol about about 2 hours, emit and make the secondary medicinal liquid.Add 900 milliliters of drinking waters for the third time, boil to extract to emit after 30 minutes and make medicinal liquid three times.After secondary medicinal liquid, three medicinal liquids merging filtrations, vacuum concentration, cold drying is made water and is promoted powder; Sterilization behind merging alcohol extraction dry powder and the water promotion powder is loaded capsule, every 0.5g of capsule.
5, instructions of taking: take Party A, Party B's capsule every day three times, each Party A 1-2 grain, Party B 4-6 grain, 2-6 month is a course of treatment.
Embodiment two:
1, Party A's crude drug weight proportion: Radix Sophorae Flavescentis 150g, Radix Berberidis 100g, Radix Isatidis 50g.
2, Party A's preparation method: add to extract irritate after by above-mentioned weight proportion, add 1100 milliliters of drinking waters for the first time the crude drug mixing, boil 20 minutes after, emit and make medicinal liquid one time.For the second time add 1000 milliliters of drinking waters, boil 10 minutes after, emit and make the secondary medicinal liquid.Add 900 milliliters of drinking waters for the third time, boil 10 minutes after, emit and make medicinal liquid three times.Medicinal liquid, secondary medicinal liquid and three medicinal liquids are merged the filtration final vacuum concentrate, dry powder is made in cold drying, will load capsule behind the dry powder sterilization, every 0.5g of capsule.
3, Party B's crude drug weight proportion: Fructus Schisandrae Chinensis 20g, Cortex Araliae Chinensis root bark 60g, Herba Artemisiae Scopariae 40g, Herb Gynostemmae Pentaphylli 45g, Radix Astragali 110g, Ganoderma 45g, Semen Cassiae 60g, Fructus Lycii 45g, Fructus Jujubae (enucleation) 45g.
4, Party B's preparation method: add to extract irritate after with the crude drug mixing by above-mentioned weight proportion, adding for the first time ethanol soaks into for 1800 milliliters and heated in 2 hours to 70 ℃ of left and right sides reflux, extract, after 40 minutes, emit and make medicinal liquid one time, alcohol extraction dry powder is made in cold drying after being concentrated into sticking cream behind the medical filtration.For the second time add 1200 milliliters of drinking waters, heat to about 90 ℃ and extract and reclaimed ethanol about about 2 hours, emit and make the secondary medicinal liquid.Add 1000 milliliters of drinking waters for the third time, boil to extract to emit after 30 minutes and make medicinal liquid three times.After secondary medicinal liquid, three medicinal liquids merging filtrations, vacuum concentration, cold drying is made water and is promoted powder; Sterilization behind merging alcohol extraction dry powder and the water promotion powder is loaded capsule, every 0.5g of capsule.
5, instructions of taking: take Party A, Party B's capsule every day three times, each Party A 1-2 grain, Party B 4-6 grain, 2-6 month is a course of treatment.
Embodiment three:
1, Party A's crude drug weight proportion: Radix Sophorae Flavescentis 180g, Radix Berberidis 120g, Radix Isatidis 70g.
2, Party A's preparation method: add to extract irritate after by above-mentioned weight proportion, add 1200 milliliters of drinking waters for the first time the crude drug mixing, boil 20 minutes after, emit and make medicinal liquid one time.For the second time add 900 milliliters of drinking waters, boil 10 minutes after, emit and make the secondary medicinal liquid.Add 900 milliliters of drinking waters for the third time, boil 10 minutes after, emit and make medicinal liquid three times.Medicinal liquid, secondary medicinal liquid and three medicinal liquids are merged the filtration final vacuum concentrate, dry powder is made in cold drying, will load capsule behind the dry powder sterilization, every 0.5g of capsule.
3, Party B's crude drug weight proportion: Fructus Schisandrae Chinensis 30g, Cortex Araliae Chinensis root bark 75g, Herba Artemisiae Scopariae 50g, Herb Gynostemmae Pentaphylli 60g, Radix Astragali 150g, Ganoderma 60g, Semen Cassiae 75g, Fructus Lycii 60g, Fructus Jujubae (enucleation) 75g.
4, Party B's preparation method: add to extract irritate after with the crude drug mixing by above-mentioned weight proportion, adding for the first time ethanol soaks into for 2000 milliliters and heated in 2 hours to 70 ℃ of left and right sides reflux, extract, after 40 minutes, emit and make medicinal liquid one time, alcohol extraction dry powder is made in cold drying after being concentrated into sticking cream behind the medical filtration.For the second time add 1500 milliliters of drinking waters, heat to about 90 ℃ and extract and reclaimed ethanol about about 2 hours, emit and make the secondary medicinal liquid.Add 1500 milliliters of drinking waters for the third time, boil to extract to emit after 30 minutes and make medicinal liquid three times.After secondary medicinal liquid, three medicinal liquids merging filtrations, vacuum concentration, cold drying is made water and is promoted powder; Sterilization behind merging alcohol extraction dry powder and the water promotion powder is loaded capsule, every 0.5g of capsule.
5, instructions of taking: take Party A, Party B's capsule every day three times, each Party A 1-2 grain, Party B 4-6 grain, 2-6 month is a course of treatment.
Observation of curative effect of the present invention is summed up:
1, clinical data: in January, 2005～2009 year clinical observation in June patient 30 examples, all meet [viral hepatitis is prevented and treated scheme] middle chronic viral hepatitis B diagnostic criteria of the tenth national infectious disease in JIUYUE, 2000 Xi'an and parasite association meeting revision, wherein: male's 22 examples, women's 8 examples; Age 18-58 year; Course of disease 1-18; Chronic mild 11 examples, chronic moderate 16 examples, chronic severe 3 examples.
2, Therapeutic Method: took A of the present invention (Party A), B (Party B) capsule first course of treatment two months, three times on the one, two of each oral A capsules, six of B capsules, every 0.5g; Took A of the present invention (Party A), B (Party B) capsule two～four months second course of treatment, and three times on the one, one of each oral A capsule, four of B capsules, every 0.5g.
3, criterion of therapeutical effect: with reference to [viral hepatitis curative effect determinate standard], clinical basic healing: transference cure, jaundice disappears, and hepatosplenomegaly retraction, hepatic region do not have to press painful and kowtow and hit painfully, and liver function is normal; Produce effects: symptom, sign have 2/3 to transfer to normally to begin a project, and ALT, AST are normal; Effectively: symptom, sign have 1/3～2/3 to transfer to normally to begin a project, and ALT, AST are higher than normal part and descend more than 50%; Invalid: symptom, sign, liver function do not have obvious improvement.
4, curative effect statistics: 30 routine patients, cure rate 33.3%, total effective rate 93.3%, inefficiency is 6.7%.
The curative effect statistics:
Curing the produce effects enabledisable adds up to
10 14 4 2 30
33.3％ 46.7％ 13.3％ 6.7％ 100％
5, model case:
(1) bent XX, man, 32 years old, security personnel.The first half of the year in 2005 returned home after hepatitis B is dismissed by unit one belongs to because of suffering from, and did not have positive effect through multi-treatment, and beginning was taken A of the present invention, B capsule four months continuously at the beginning of 2005 10 months, and is normal through the check liver function recovery, reverts working unit immediately so far.
(2) Guo xx, woman, 18 years old, student.At the beginning of 2006, go home to cure the disease because of finding hepatitis B, suspending schooling, rise in March, 2006, took A of the present invention, B capsule continuously six months, and hepatitis B is controlled, and JIUYUE is returned to school and continued study.
(3) king xx, man, 25 years old, peasant.November in 2005 was diagnosed as hepatitis B through certain Army Hospital before five months, and through the no positive effect of treatment, liver power checking: jaundice is several 10, and Moschus moschiferous is turbid 12, Gao Tianshi (ten), and VDB is direct, indirectly equal (ten), SGPT160HbsAg (ten).Require voluntarily to take A of the present invention, B capsule, after taking continuously in four months, check liver function SGPT reduces to below 40, and HBsAg is (one), and hepatitis symptom is eliminated.
Claims (2)
1. the medicine of prevention and treatment hepatitis B is characterized in that described medicine is made up of Party A and Party B; The Party A is made by the raw material of following weight ratio: Radix Sophorae Flavescentis 120-180, Radix Berberidis 80-120, Radix Isatidis 30-70; The Party B is made by the raw material of following weight ratio: Fructus Schisandrae Chinensis 5-30, Cortex Araliae Chinensis root bark 45-75, Herba Artemisiae Scopariae 30-50, Herb Gynostemmae Pentaphylli 30-60, Radix Astragali 45-150, Ganoderma 30-60, Semen Cassiae 45-75, Fructus Lycii 30-60, Fructus Jujubae 30-75.
2. the preparation method of the medicine of described prevention of claim 1 and treatment hepatitis B is characterized in that:
(1) Party A's preparation method: get by weight ratio and add suitable quantity of water behind the crude drug mixing and boil and make medicinal liquid one time, adding for the second time suitable quantity of water boils and makes the secondary medicinal liquid, adding suitable quantity of water for the third time boils and makes medicinal liquid three times, medicinal liquid, secondary medicinal liquid and three medicinal liquids are merged the filtration final vacuum be concentrated into sticking cream, to glue the cream cold drying and make dry powder, will load capsule behind the dry powder sterilization;
(2) Party B's preparation method: get the crude drug mixing by weight ratio and add earlier an amount of ethanol and heat and make medicinal liquid one time, will be concentrated into sticking cream behind the medical filtration, will glue the cream cold drying and make alcohol extraction dry powder to 70 ℃ of reflux, extract; Adding for the second time suitable quantity of water heats and extracts and reclaim ethanol to about 90 ℃ and make the secondary medicinal liquid; Add suitable quantity of water for the third time and boil to extract and make medicinal liquid three times, secondary medicinal liquid, three medicinal liquids are merged filter final vacuums and be concentrated into sticking cream, will glue the cream cold drying and make water and promote powder; Sterilization behind merging alcohol extraction dry powder and the water promotion powder is loaded capsule.
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| CN2009102192611A CN101703568B (en) | 2009-11-19 | 2009-11-19 | Medicament for preventing and treating hepatitis B and preparation method thereof |
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| CN2009102192611A CN101703568B (en) | 2009-11-19 | 2009-11-19 | Medicament for preventing and treating hepatitis B and preparation method thereof |
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| CN101703568B true CN101703568B (en) | 2011-07-20 |
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2009
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Non-Patent Citations (1)
| Title |
|---|
| 姚树汉，等.中医药治疗脂肪肝的研究进展.《云南中医中药杂志》.2008,第29卷(第7期),第60-62页. * |
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