CN101701001A - β-氨基丙酸的制备方法 - Google Patents
β-氨基丙酸的制备方法 Download PDFInfo
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- CN101701001A CN101701001A CN200910063280A CN200910063280A CN101701001A CN 101701001 A CN101701001 A CN 101701001A CN 200910063280 A CN200910063280 A CN 200910063280A CN 200910063280 A CN200910063280 A CN 200910063280A CN 101701001 A CN101701001 A CN 101701001A
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- jibingsuan
- reactor
- reaction
- temperature
- ammonia
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Links
- 238000000034 method Methods 0.000 title claims abstract description 11
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims abstract description 38
- 238000006243 chemical reaction Methods 0.000 claims abstract description 36
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 26
- 229910021529 ammonia Inorganic materials 0.000 claims abstract description 19
- 235000011114 ammonium hydroxide Nutrition 0.000 claims abstract description 13
- 239000006188 syrup Substances 0.000 claims abstract description 12
- 235000020357 syrup Nutrition 0.000 claims abstract description 12
- 235000012538 ammonium bicarbonate Nutrition 0.000 claims abstract description 10
- 238000002360 preparation method Methods 0.000 claims abstract description 8
- 238000002156 mixing Methods 0.000 claims abstract description 6
- 239000007788 liquid Substances 0.000 claims description 21
- 239000012043 crude product Substances 0.000 claims description 15
- 238000010521 absorption reaction Methods 0.000 claims description 10
- 238000004821 distillation Methods 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 7
- 238000010792 warming Methods 0.000 claims description 7
- 238000009835 boiling Methods 0.000 claims description 5
- 238000002425 crystallisation Methods 0.000 claims description 5
- 230000008025 crystallization Effects 0.000 claims description 5
- 235000008504 concentrate Nutrition 0.000 claims description 2
- 239000012141 concentrate Substances 0.000 claims description 2
- 238000001953 recrystallisation Methods 0.000 claims description 2
- 239000002994 raw material Substances 0.000 abstract description 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 abstract 5
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 abstract 3
- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 abstract 3
- 239000001099 ammonium carbonate Substances 0.000 abstract 3
- 239000012295 chemical reaction liquid Substances 0.000 abstract 3
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 235000011837 pasties Nutrition 0.000 abstract 1
- 238000006116 polymerization reaction Methods 0.000 abstract 1
- 238000003825 pressing Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 description 4
- 239000007795 chemical reaction product Substances 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 229940000635 beta-alanine Drugs 0.000 description 2
- 230000006837 decompression Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 description 1
- 108010087806 Carnosine Proteins 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- IPOKCKJONYRRHP-FMQUCBEESA-N balsalazide Chemical compound C1=CC(C(=O)NCCC(=O)O)=CC=C1\N=N\C1=CC=C(O)C(C(O)=O)=C1 IPOKCKJONYRRHP-FMQUCBEESA-N 0.000 description 1
- 229960004168 balsalazide Drugs 0.000 description 1
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 1
- 229960002079 calcium pantothenate Drugs 0.000 description 1
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 description 1
- 229940044199 carnosine Drugs 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- WRUUGTRCQOWXEG-UHFFFAOYSA-N pamidronate Chemical compound NCCC(O)(P(O)(O)=O)P(O)(O)=O WRUUGTRCQOWXEG-UHFFFAOYSA-N 0.000 description 1
- 229940046231 pamidronate Drugs 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- FVSKHRXBFJPNKK-UHFFFAOYSA-N propionitrile Chemical compound CCC#N FVSKHRXBFJPNKK-UHFFFAOYSA-N 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229940083542 sodium Drugs 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- 235000014268 sports nutrition Nutrition 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200910063280.XA CN101701001B (zh) | 2009-07-22 | 2009-07-22 | β-氨基丙酸的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200910063280.XA CN101701001B (zh) | 2009-07-22 | 2009-07-22 | β-氨基丙酸的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101701001A true CN101701001A (zh) | 2010-05-05 |
CN101701001B CN101701001B (zh) | 2014-05-28 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200910063280.XA Expired - Fee Related CN101701001B (zh) | 2009-07-22 | 2009-07-22 | β-氨基丙酸的制备方法 |
Country Status (1)
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CN (1) | CN101701001B (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108892621A (zh) * | 2018-07-25 | 2018-11-27 | 浙江新和成股份有限公司 | 一种采用微通道反应器制备β-氨基丙酸的方法 |
CN112174840A (zh) * | 2020-09-27 | 2021-01-05 | 安徽泰格生物科技有限公司 | 一种β-氨基丙酸的制备方法 |
CN112457181A (zh) * | 2020-12-11 | 2021-03-09 | 黄冈美丰化工科技有限公司 | 一种d-泛酸钙的合成方法 |
CN113979879A (zh) * | 2021-09-26 | 2022-01-28 | 万华化学集团股份有限公司 | 一种高效制备β-氨基丙酸的方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3846489A (en) * | 1970-12-29 | 1974-11-05 | Tokyo Fine Chem Co Ltd | Process for production of beta-alanine |
GB1379268A (en) * | 1972-06-30 | 1975-01-02 | Tokyo Fine Chemical Co Ltd | Process for production of beta-alanine |
-
2009
- 2009-07-22 CN CN200910063280.XA patent/CN101701001B/zh not_active Expired - Fee Related
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108892621A (zh) * | 2018-07-25 | 2018-11-27 | 浙江新和成股份有限公司 | 一种采用微通道反应器制备β-氨基丙酸的方法 |
CN108892621B (zh) * | 2018-07-25 | 2020-11-17 | 浙江新和成股份有限公司 | 一种采用微通道反应器制备β-氨基丙酸的方法 |
CN112174840A (zh) * | 2020-09-27 | 2021-01-05 | 安徽泰格生物科技有限公司 | 一种β-氨基丙酸的制备方法 |
CN112174840B (zh) * | 2020-09-27 | 2023-08-18 | 安徽泰格生物科技有限公司 | 一种β-氨基丙酸的制备方法 |
CN112457181A (zh) * | 2020-12-11 | 2021-03-09 | 黄冈美丰化工科技有限公司 | 一种d-泛酸钙的合成方法 |
CN112457181B (zh) * | 2020-12-11 | 2023-08-29 | 黄冈美丰化工科技有限公司 | 一种d-泛酸钙的合成方法 |
CN113979879A (zh) * | 2021-09-26 | 2022-01-28 | 万华化学集团股份有限公司 | 一种高效制备β-氨基丙酸的方法 |
Also Published As
Publication number | Publication date |
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CN101701001B (zh) | 2014-05-28 |
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Owner name: ZHANG JINGHUA Free format text: FORMER OWNER: XIANTAO GAOSHENG FINE CHEMICAL CO., LTD. Effective date: 20101214 |
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Free format text: CORRECT: ADDRESS; FROM: 433000 NO.20, QINGYUHU ROAD, XIANTAO CITY, HUBEI PROVINCE TO: 433000 ROOM 201, UNIT 1, BUILDING 1, WUXING HUAYUAN, SPECIAL NO.1, HANJIANG ROAD, XIANTAO CITY, HUBEI PROVINCE |
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TA01 | Transfer of patent application right |
Effective date of registration: 20101214 Address after: 433000 Hubei province Xiantao Hanjiang Road, a five-star Garden a unit Room 201 Applicant after: Zhang Jinghua Address before: 433000 No. 20 herring Lake Road, Hubei, Xiantao Applicant before: Xiantao Gaosheng Fine Chemical Co., Ltd. |
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CF01 | Termination of patent right due to non-payment of annual fee |
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