CN101623085A - Composition containing probiotics and stachyose - Google Patents
Composition containing probiotics and stachyose Download PDFInfo
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- CN101623085A CN101623085A CN200810068299A CN200810068299A CN101623085A CN 101623085 A CN101623085 A CN 101623085A CN 200810068299 A CN200810068299 A CN 200810068299A CN 200810068299 A CN200810068299 A CN 200810068299A CN 101623085 A CN101623085 A CN 101623085A
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- stachyose
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- bifidobacterium
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Abstract
The invention provides a composition containing probiotics and stachyose, which is a composition of the probiotics containing three or more than three of bifidobacterium, lactobacillus acidophilus, streptococcus thermophilus, lactobacillus rhamnosus and the like and the stachyose. The composition is characterized by comprising the following components in portion by weight: 1 to 99 percent of the stachyose (containing raffinose), 1 to 20 percent of the probiotics, and 0 to 30 percent of additive. The composition has the aim that the probiotics which are in the human intestinal canals and are shielded by gastric acid can be quickly activated and propagated by directly supplementing the number of the probiotics in the human intestinal canals and simultaneously providing a specific growth promotion substance, namely the stachyose to regulate and improve the micro-ecological balance of intestinal canal microbial flora so as to achieve the aims of improving the immunity of the organism and improving the functions of the stomach and intestine.
Description
Technical field
The present invention relates to a kind of composition that contains probio and stachyose, belong to the category of probiotics.Microecologic regulator is the preparation of microecosystem balance in the host, and it can play the effect that improves the host health level.Can be divided into probiotic (Probiotic), beneficial three kinds of matter (Prebiotic), the Synbiotics (Synbiotic) of giving birth to by its formation, the present invention is a kind of Synbiotics, probio and the efficient factor one stachyose that promotes are organically combined, the death rate when effectively reducing probio by hydrochloric acid in gastric juice, and the probio that enters behind the enteron aisle can be bred rapidly, quick adjustment and improve the intestinal microecology system reaches and regulates immunity, suppresses tumour, regulates blood fat, improves a series of treatments and health-care efficacy such as function of intestinal canal.
Background technology
Since 20th century mankind so far to little ecological Studies, microecology has obtained significant progress, especially the application of aspects such as its prevention in disease, treatment, health care has obtained paying attention to widely, studies show that in a large number: the digestion of the nutrition of normal flora and human body and be absorbed with substantial connection in the human body intestinal canal, normal flora has been participated in the absorption and the metabolism of cholesterol, steroids, fat, protein, lipoid, amino acid and some drugs.The metabolite of probiotics fermention sugar produces a large amount of acetate and lactic acid, the low pH and suboxides reduction potential (Eh) environment that cause enteron aisle, this helps the absorption of iron, calcium and vitamin D very much, the sour environment that the while fermenting carbohydrate causes can suppress many pathogens, can also promote enterocinesia, prevent the transition breeding of bacterium.The multiple antigenic substance that normal flora produced can stimulate body generation immune response, makes immune system keep state of activation, plays immunization.Research is also found: probio can degrade nitrous acid ammonia and nitrite, eliminate the carcinogenicity of nitrous acid ammonia.Therefore become the core of little ecological heat for the research of probio.
Other probio physiological action such as lactobacillus acidophilus is only second to Bifidobacterium.These bacterium can be in enteron aisle the part definite value, harmless and useful, can synthetic vitamin, assist digestion food helps nutrient absorption, promotes organism metabolism.These bacterium produce sour in enteron aisle, and collaborative Bifidobacterium suppresses harmful bacterium, overcomes decay process, reduce the generation of harmful substance and the eliminating of acceleration harmful substance.These bacterium can also reduce the body cholesterol, strengthen the endurance of body to lactic acid.Through the sour milk of lactobacillus acidophilus, streptococcus thermophilus fermentation, human edible T﹠B, well received, this also illustrates the benefit of these bacterium to the mankind.The bacteriocin that lactobacillus acidophilus, streptococcus thermophilus produce has the obvious suppression effect to lactobacillus, sheet coccus, bright string coccus, galactococcus.Ministry of Health of the People's Republic of China issues " the probio bacterial classification list that can be used for health food " (defending the method prison sends out [2001] No. 84) on April calendar year 2001 9 and has wherein just comprised above-mentioned all probios.
Whether healthy the quantity of probio become check human body index in the human body.It can reduce the physiological action of human body:
1. antibiotic property, its antibacterial action mechanism produces organic acid and causes enteron aisle pH to descend suppressing spoilage organisms for decomposing carbohydrate, and simultaneously, its metabolite also has inhibitory action to saprophytic bacteria; Can make the coupling bile acid be decomposed into free bile acid, this acid is stronger to bacteriostasis, and after saprophytic bacteria was suppressed, the harmful substances such as indoles, phenol, ammonia and cadaverine in the human body also obviously reduced.
2. replenish the vitamin of needed by human body.Probio can produce various vitamins as: VB1, VB2, VB6, VB12, nicotinic acid and folic acid etc. can also decompose the supply that ensures vitamin by suppressing some vitamin for needed by human body.
3. the anti-effect that treats constipation.The organic acid that the probio metabolism is produced can make the interior osmotic pressure of intestinal tube increase, and moisture increases in the ight soil, can promote the intestinal tube wriggling simultaneously, so can prevent constipation.
4. liver function is improved.Saprophytic bacteria can produce metabolins such as a large amount of indoles, hydrogen sulfide, amine in the enteron aisle, need liver detoxification, get rid of with forms such as glucuronic acid salt subsequently, if untimely detoxifcation will cause liver dysfunction and the circulatory system is not normal, disturb nervous system and influence sleep, probio can absorb these nitrogen substances, suppresses to produce the spoilage organisms of amine.
5. strengthen immunologic function.The mechanism of action: probio produces the intestine immunity cell to be stimulated, and plays the effect that wards off disease by improving intestine immunity globulin A (LgA) thick liquid cell generation ability.
6. prevent intestinal canal tumour.The enteron aisle saprophytic bacteria can produce many amine carcinogens in metabolism, what have can also be converted into carcinogenic substance with some carcinogenic precursor substances, and probio plays the effect that prevents the enteron aisle cancer by growth and the decompose carcinogenic substances that suppresses saprophytic bacteria.
The active bacteria formulation quantity of present probio both domestic and external is a lot, also exists the limitation that existing science and technology is difficult to overcome but find in actual applications that these active bacteria formulations are used to adjust and improve the intestinal microecology balance.No matter 1. which kind of formulation product must pass through especially hydrochloric acid in gastric juice of alimentary canal, thereby is easy to lose activity.2. by survival rate behind the hydrochloric acid in gastric juice barrier and the field planting problem that reaches enteron aisle.The short biology of probio is the another kind of approach of adjusting intestinal microecology, at present this research is on the one hand concentrated on the compound sugar that is called as " two qi factor ", though the active bacteria formulation of existing FOS and Bifidobacterium on the market, but shortcoming such as the prior function compound sugar all exists, and efficacy factor is indeterminate, complicated component, onset dosage are big, and can not breed lactobacillus acidophilus or other probio, thereby effect is relatively poor.
Stachyose (Stachyose) is a kind of novel functional oligose, it is the MF of probio, the compound sugar that stachyose is made up of galactolipin, glucose, fructose connects 2 galactolipins in glucosyl group one side with α-(1,6) glycosidic bond in the molecule and promptly constitutes stachyose.Because lack the enzyme α-D-Ban Rutangganmei of hydrolysis water threose in the human body, so they can not be absorbed by human consumption, most of flora in the human body does not have corresponding enzyme system yet, therefore can not utilize, the minority probio that only resides in the enteron aisle has this enzyme system, so stachyose has just become the specificity of these probios short biological.The stachyose efficacy factor is clear and definite, and structure is clear, has well remedied the defective of existing product aspect quality and effect.Be described as third generation functional oligose, have good prospects.
Goal of the invention the objective of the invention is to by directly replenishing probio quantity in the human body intestinal canal; supply with the short biology-stachyose of specificity simultaneously; the protection probio is effectively by the hydrochloric acid in gastric juice barrier; and quick active, field planting are also bred in enteron aisle, reach the purpose of adjusting and improving the intestinal microecology balance.Thereby improving immunity of organism manages, delays senility, suppresses tumour, regulates blood fat, improves function such as stomach and intestine.
Summary of the invention
In order to achieve the above object, a kind of composition that contains probio and stachyose of the present invention, each composition accounts for weight ratio and is:
Stachyose 1%-90%
Probio 1%-20%
Additive 0-30%
The used stachyose of the present invention means the product of highly purified stachyose, and purity is greater than 50%.Probio of the present invention is the mixture of any in the probios such as Bifidobacterium, lactobacillus acidophilus, streptococcus thermophilus, Lactobacillus rhamnosus bacterial classification more than three kinds or three kinds, the ratio of mixing is 1%-99%, can be viable bacteria, the viable bacteria freeze-dried powder, the extract of dead bacterium or somatic cells, bacterial classification comprise people source type, wild type and the variant that goes down to posterity, tame etc.Bifidobacterium can comprise bifidobacterium infantis (B.infants), bifidobacterium longum (B.longum), bifidobacterium breve (B.breve), two qi Bifidobacteriums (B.bifidum), bifidobacterium adolescentis (B.adolessentis), etc.;
Additive of the present invention can be the various food additives that food hygiene requires that meet.The present invention can be tablet, electuary, capsule, oral liquid or other peroral dosage form.
Through carrying out the experiment of in-vitro multiplication effect, we find that stachyose has tangible proliferation function to vigor and the quantity of multiple probio.In order to estimate the security of the composition that contains probio and stachyose, carried out mouse LD
50, marrow micronucleus, sperm distortion and Salmonella reversion test, prove to the invention belongs to actual nontoxic level material that body cell is not had mutagenesis, reproduction cell is not had the mutagenesis teratogenesis, no direct or indirect mutagenesis.
In sum, this composition that contains probio and stachyose has its original feature, through the online information retrieval in pertinent literature storehouse both at home and abroad, does not see the patent of invention of identical bacterial classification and ratio.Illustrate that this prescription has advance and practicality aspect treatment and the health care.
Concrete embodiment
Embodiment 1:
Stachyose 80% lactobacillus acidophilus freeze-drying powder 3%
Bifidobacterium freeze-dried powder 10% streptococcus thermophilus freeze-dried powder 7%
Embodiment 2:
Stachyose 84% lactobacillus acidophilus freeze-drying powder 5%
Bifidobacterium freeze-dried powder 6% Lactobacillus rhamnosus freeze-dried powder 5%
Embodiment 3
Stachyose 79% lactobacillus acidophilus freeze-drying powder 5%
Bifidobacterium freeze-dried powder 4% streptococcus thermophilus freeze-dried powder 6%
Food additives 6%
Embodiment 4
Stachyose 50% streptococcus thermophilus freeze-dried powder 6%
The dead full cell 20% lactobacillus acidophilus freeze-drying powder 15% of Bifidobacterium
Additive 9%
Embodiment 5
Stachyose 62% streptococcus thermophilus extract 6%
Bifidobacterium extract 20% lactobacillus acidophilus extract 10%
Additive 2%
Claims (5)
1, a kind of composition that contains probio and stachyose contains probio, stachyose and other additive, it is characterized in that (% meter by weight):
Stachyose 1%-99%
Probio 1%-20%
Additive 0%-30%
2, a kind of composition that contains probio and stachyose according to claim 1 is characterized in that containing new type functional compound sugar-stachyose (Stachyose), and its content is 1%-99%.
3, a kind of composition that contains probio and stachyose according to claim 1, it is characterized in that: contained probio is any more than three kinds or three kinds in Bifidobacterium, lactobacillus acidophilus, streptococcus thermophilus, the Lactobacillus rhamnosus, and the ratio of its bacterium is: 1%-99%.
4, according to claim 1,3 described a kind of compositions that contain probio and stachyose, it is characterized in that: contained probio can be viable bacteria, also can be the extracting section thing of dead bacterium or somatic cells.
5, a kind of composition that contains probio and stachyose according to claim 1, it is characterized in that: additive comprises the various food additives that comply with the national standard requirements.Formulation can be tablet, capsule, electuary, oral liquid or other formulation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810068299A CN101623085A (en) | 2008-07-08 | 2008-07-08 | Composition containing probiotics and stachyose |
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| Application Number | Priority Date | Filing Date | Title |
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| CN200810068299A CN101623085A (en) | 2008-07-08 | 2008-07-08 | Composition containing probiotics and stachyose |
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| CN101623085A true CN101623085A (en) | 2010-01-13 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103653170A (en) * | 2013-11-21 | 2014-03-26 | 荣成百合生物技术有限公司 | Stachyose probiotics solid beverage |
| CN103815224A (en) * | 2014-01-28 | 2014-05-28 | 宁波大学 | Stachyose effervescent tablet and preparation method thereof |
| CN107815432A (en) * | 2017-12-07 | 2018-03-20 | 广州柏芳生物科技有限公司 | A kind of people uses inactivation lactobacillus preparation and application thereof |
| CN108783173A (en) * | 2018-05-28 | 2018-11-13 | 郑州清华园生物工程有限公司 | A kind of compound stachyose solid beverage and preparation method thereof |
| CN111840336A (en) * | 2020-07-15 | 2020-10-30 | 西安小天使生命营养科学健康研究院有限公司 | Probiotics stachyose and preparation process thereof |
| CN113261675A (en) * | 2021-06-02 | 2021-08-17 | 河北源民生物科技有限公司 | Probiotic composition suitable for human immunity |
-
2008
- 2008-07-08 CN CN200810068299A patent/CN101623085A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103653170A (en) * | 2013-11-21 | 2014-03-26 | 荣成百合生物技术有限公司 | Stachyose probiotics solid beverage |
| CN103653170B (en) * | 2013-11-21 | 2015-06-10 | 威海百合生物技术股份有限公司 | Stachyose probiotics solid beverage |
| CN103815224A (en) * | 2014-01-28 | 2014-05-28 | 宁波大学 | Stachyose effervescent tablet and preparation method thereof |
| CN103815224B (en) * | 2014-01-28 | 2016-01-20 | 宁波大学 | A kind of stachyose effervescent tablet and preparation method thereof |
| CN107815432A (en) * | 2017-12-07 | 2018-03-20 | 广州柏芳生物科技有限公司 | A kind of people uses inactivation lactobacillus preparation and application thereof |
| CN107815432B (en) * | 2017-12-07 | 2021-09-28 | 广州柏芳生物科技有限公司 | Inactivated lactobacillus preparation for human and application thereof |
| CN108783173A (en) * | 2018-05-28 | 2018-11-13 | 郑州清华园生物工程有限公司 | A kind of compound stachyose solid beverage and preparation method thereof |
| CN111840336A (en) * | 2020-07-15 | 2020-10-30 | 西安小天使生命营养科学健康研究院有限公司 | Probiotics stachyose and preparation process thereof |
| CN113261675A (en) * | 2021-06-02 | 2021-08-17 | 河北源民生物科技有限公司 | Probiotic composition suitable for human immunity |
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Open date: 20100113 |