CN101612105A - Whitening and skin-protecting Chinese medicine composition and preparation method thereof - Google Patents
Whitening and skin-protecting Chinese medicine composition and preparation method thereof Download PDFInfo
- Publication number
- CN101612105A CN101612105A CN200910055819A CN200910055819A CN101612105A CN 101612105 A CN101612105 A CN 101612105A CN 200910055819 A CN200910055819 A CN 200910055819A CN 200910055819 A CN200910055819 A CN 200910055819A CN 101612105 A CN101612105 A CN 101612105A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- medicine composition
- whitening
- skin
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of whitening and skin-protecting Chinese medicine composition and preparation method thereof, Chinese medicine composition by the Pseudobulbus Bletillae (Rhizoma Bletillae), hold back in vain, the extract of Cortex Mori, Poria, Fructus Atriplicis Sibiricae, the Rhizoma Atractylodis Macrocephalae, Fructus Amomi Rotundus, the Radix Paeoniae Alba, Herba Pyrolae and Radix Angelicae Sinensis forms, and any one Chinese medicinal components all is no more than 20% of extract gross weight.Preparation method is that each Chinese medicinal components is used the alcohol-pickled of mass concentration 20%～80%, the ethanol consumption that soaks usefulness is 20～50 times of Chinese medicinal components gross weight, then soak is concentrated 10～50 times after filtering, the concentrated solution macroporous resin adsorption, the ethanol of reuse mass concentration 10%～98% is eluting repeatedly, collect eluent, make the traditional Chinese medicine composition extract liquid that comprises the plurality of Chinese extract.Advantage is: compare with existing like product have effect obviously, have the dual function that suppresses melanin and promote Skin Cell new life, and pure natural, safety is good.Can be widely used in preparation whitening skin care product or medicine.
Description
Technical field
The present invention relates to the hold concurrently Chinese prescription of face-nursing function of a kind of Pear Power, this prescription by the Pseudobulbus Bletillae (Rhizoma Bletillae), hold back in vain, the extract of Cortex Mori, Poria, Fructus Atriplicis Sibiricae, the Rhizoma Atractylodis Macrocephalae, Fructus Amomi Rotundus, the Radix Paeoniae Alba, Herba Pyrolae and Radix Angelicae Sinensis forms, can be used for whitening and the cosmetics and the medicine of skin nursing.
Background technology
Whiten and skin nursing is the most important themes of cosmetics, prove that melanic formation is subjected to influence of various factors through modern scientific research, whiten and skin nursing is the result of very complicated multipath effect.And whitening of adopting at present and skin care cosmetics additive great majority exist effect indeterminate and the problem of certain untoward reaction occurs.
Along with growth in the living standard and human sciences's accumulation of knowledge, very big variation has taken place for the requirement of whitening with the skin care cosmetics in people.
Whitening additive at present commonly used is as vitamin C, because the chemical constitution instability is difficult to use in cosmetics; Kojic acid, owing to have certain zest, variable color easily simultaneously, and be difficult in cosmetics, use; Arbutin, effect is by way of single, and whitening effect is not ideal enough.So people be starved of have that effect is clear and definite, effect by way of various, safely, the natural whiting, the skin care composition that have no adverse reaction.
Summary of the invention
Technical problem to be solved by this invention be to provide a kind of have multiple effect by way of, can effectively suppress melanin and promote Skin Cell new life's whitening and skin-protecting Chinese medicine composition.
Another technical problem to be solved by this invention is to provide the preparation method of above-mentioned whitening and skin-protecting Chinese medicine composition.
A technical problem more to be solved by this invention is to provide the purposes of above-mentioned whitening and skin-protecting Chinese medicine composition, comprises being used to prepare skin-lightening cosmetic, skin care item and medicine.
The present invention solves the problems of the technologies described above the technical scheme of being taked: a kind of whitening and skin-protecting Chinese medicine composition, wherein, described Chinese medicine composition by the Pseudobulbus Bletillae (Rhizoma Bletillae), hold back in vain, the extract of Cortex Mori, Poria, Fructus Atriplicis Sibiricae, the Rhizoma Atractylodis Macrocephalae, Fructus Amomi Rotundus, the Radix Paeoniae Alba, Herba Pyrolae and Radix Angelicae Sinensis forms, and any one Chinese medicine extract all is no more than 20% of extract gross weight.
On the basis of such scheme, by weight percentage, the content of described each Chinese medicine extract is: the Pseudobulbus Bletillae (Rhizoma Bletillae) 1～20%, hold back 1～20% in vain, Cortex Mori 1～20%, Poria 1～20%, Fructus Atriplicis Sibiricae 1～20%, the Rhizoma Atractylodis Macrocephalae 1～20%, Fructus Amomi Rotundus 1～20%, the Radix Paeoniae Alba 1～20%, Herba Pyrolae 1～20% and Radix Angelicae Sinensis 1～20%.
The concrete consumption of each component can for:
The Pseudobulbus Bletillae (Rhizoma Bletillae) 1,2,3,5,6,8,10,12,13,15,16,18 or 20%;
Hold back 1,2,3,5,6,8,10,12,13,15,16,18 or 20% in vain;
Cortex Mori 1,2,3,5,6,8,10,12,13,15,16,18 or 20%;
Poria 1,2,3,5,6,8,10,12,13,15,16,18 or 20%;
Fructus Atriplicis Sibiricae 1,2,3,5,6,8,10,12,13,15,16,18 or 20%;
The Rhizoma Atractylodis Macrocephalae 1,2,3,5,6,8,10,12,13,15,16,18 or 20%;
Fructus Amomi Rotundus 1,2,3,5,6,8,10,12,13,15,16,18 or 20%;
The Radix Paeoniae Alba 1,2,3,5,6,8,10,12,13,15,16,18 or 20%;
Herba Pyrolae 1,2,3,5,6,8,10,12,13,15,16,18 or 20%;
Radix Angelicae Sinensis 1,2,3,5,6,8,10,12,13,15,16,18 or 20%.
On the basis of such scheme, the optimization formula of each Chinese medicinal components is: the Pseudobulbus Bletillae (Rhizoma Bletillae) 2～15%, hold back 2～15% in vain, Cortex Mori 2～15%, Poria 2～15%, Fructus Atriplicis Sibiricae 2～15%, the Rhizoma Atractylodis Macrocephalae 2～15%, Fructus Amomi Rotundus 2～15%, the Radix Paeoniae Alba 2～15%, Herba Pyrolae 5～20% and Radix Angelicae Sinensis 2～15%.
Preparation method at above-mentioned whitening and skin-protecting Chinese medicine composition, each Chinese medicinal components is used the alcohol-pickled of mass concentration 20%～80%, the ethanol consumption that soaks usefulness is 20～300 times (being preferably 20～50 times) of Chinese medicinal components gross weight, soak concentrates 10～50 times after filtering then, the concentrated solution macroporous resin adsorption, the ethanol of reuse mass concentration 10%～98% is eluting repeatedly, collects eluent, makes the traditional Chinese medicine composition extract liquid that comprises each Chinese medicine extract.
Concrete, the ethanol consumption that soaks usefulness can be 20,22,25,28,30,32,35,38,40,42,45,48,50,60,80,100 of Chinese medicinal components gross weight, 120,150,180,200,220,250,280 or 300 times; Soak can concentrate 10,15,20,25,30,35,40,45 or 50 times after filtering.
On the basis of such scheme, in immersion process, earlier with alcohol-pickled 2～48 hours of mass concentration 20%～80%, alcohol-pickled 2～48 hours of residue reuse mass concentration 20%～80% merge the solution after soaking, soak.
Each soak time is specifically as follows 2,4, and 8,12,16,20,24,28,32,36,40,44 or 48 hours.
On the basis of such scheme, in filter process, used filter screen order number is 180～250 orders, preferred 200 orders of filter screen order number.
The purposes of the whitening and skin-protecting Chinese medicine composition that makes at said method, be used to prepare whitening skin care product or medicine, comprise cream, paste, ointment, ointment, Emulsion, oil preparation, face film agent, gel, liniment, aerosol or solution (comprising lotion, liniment) or the like.
On the basis of such scheme, with the traditional Chinese medicine composition extract liquid that makes through being evaporated to 1/2～1/5 of former weight, obtain the Chinese medicine composition concentrated solution, be used to prepare whitening skin care product or medicine, wherein, described Chinese medicine composition concentrated solution accounts for 5～10% of whitening skin care product or medicine gross weight.
Concrete, the concentrating under reduced pressure of traditional Chinese medicine composition extract liquid can be down to 1/2,1/3,1/4 or 1/5 of original weight amount; The Chinese medicine composition concentrated solution can account for 5,6,7,8,9 or 10% of whitening skin care product or medicine gross weight.
When the above-mentioned external whitening product of preparation, the substrate of employing, adjuvant, carrier, additive etc. are prior art, and preparation method is also mixed, prepared according to conventional method.
The invention has the beneficial effects as follows:
The Chinese medicine that the present invention selects ten flavor Pear Power skin effects makes up, and this Chinese medicine composition is not in the news as yet up to now or is used to whiten and skin nursing.The present invention compares with existing like product has the dual function that effect is obvious, have inhibition melanin and promotion Skin Cell new life, and pure natural, and safety is good.Preparation whitening skin care product or medicine be can be widely used in, cream, paste, ointment, ointment, Emulsion, oil preparation, face film agent, gel, liniment, aerosol or lotion or the like comprised.
The specific embodiment
Below by implementation column the present invention is done further detailed elaboration.
Embodiment 1
At room temperature, get the Chinese medicine Pseudobulbus Bletillae (Rhizoma Bletillae), hold back in vain, Cortex Mori, Poria, Fructus Atriplicis Sibiricae, the Rhizoma Atractylodis Macrocephalae, Fructus Amomi Rotundus, the Radix Paeoniae Alba, Herba Pyrolae and Radix Angelicae Sinensis each 10 kilograms (totally 100 kilograms), elder generation was with alcohol-pickled 24 hours of 1200 kilograms of mass concentrations 50%, the ethanol of residue reuse mass concentration 50% soaked 24 hours for 1200 kilograms, solution after soaking is merged, get soak; Then soak is concentrated 20 times after through 200 purpose strainer filterings, use macroporous resin adsorption, reuse mass concentration 40% ethanol is eluting repeatedly, and the collection eluent makes the traditional Chinese medicine composition extract liquid that comprises the plurality of Chinese extract.
Embodiment 2
At room temperature, get the Pseudobulbus Bletillae (Rhizoma Bletillae), hold back in vain, Cortex Mori, Poria, Fructus Atriplicis Sibiricae, the Rhizoma Atractylodis Macrocephalae, Fructus Amomi Rotundus, the Radix Paeoniae Alba, Herba Pyrolae and Radix Angelicae Sinensis each 10 kilograms (totally 100 kilograms), elder generation was with alcohol-pickled 40 hours of 1500 kilograms of mass concentrations 80%, alcohol-pickled 40 hours of 1500 kilogram 80% of residue reuse, solution after soaking is merged, get soak; Soak concentrates 30 times after through 200 purpose strainer filterings then, use macroporous resin adsorption, and reuse mass concentration 70% ethanol is eluting repeatedly, and the collection eluent makes the traditional Chinese medicine composition extract liquid that comprises the plurality of Chinese extract.
Embodiment 3
Preparation method is identical with embodiment 1, just Chinese medicinal components proportioning difference.
8 kilograms of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, hold back 8 kilograms, 8 kilograms of Cortex Mori, 8 kilograms of Porias, 8 kilograms of Fructus Atriplicis Sibiricaees, 8 kilograms of the Rhizoma Atractylodis Macrocephalaes, 8 kilograms of Fructus Amomi Rotunduss, 9 kilograms of the Radix Paeoniae Albas, 20 kilograms of Herba Pyrolaes and 15 kilograms of Radix Angelicae Sinensis (totally 100 kilograms) in vain; The ethanol total amount of soaking usefulness is 2800 kilograms.
Embodiment 4
Preparation method is identical with embodiment 1, just Chinese medicinal components proportioning difference.
2 kilograms of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, hold back 5 kilograms, 5 kilograms of Cortex Mori, 3 kilograms of Porias, 15 kilograms of Fructus Atriplicis Sibiricaees, 13 kilograms of the Rhizoma Atractylodis Macrocephalaes, 15 kilograms of Fructus Amomi Rotunduss, 15 kilograms of the Radix Paeoniae Albas, 15 kilograms of Herba Pyrolaes and 12 kilograms of Radix Angelicae Sinensis (totally 100 kilograms) in vain; The ethanol total amount of soaking usefulness is 3600 kilograms.
Embodiment 5
Preparation method is identical with embodiment 1, just Chinese medicinal components proportioning difference.
5 kilograms of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, hold back 6 kilograms of 12 kilograms, 12 kilograms of Cortex Mori, 12 kilograms of Porias, 3 kilograms of Fructus Atriplicis Sibiricaees, 6 kilograms of the Rhizoma Atractylodis Macrocephalaes, 14 kilograms of Fructus Amomi Rotunduss, 12 kilograms of the Radix Paeoniae Albas, 18 kilograms of Herba Pyrolaes and Radix Angelicae Sinensis in vain.(totally 100 kilograms); The ethanol total amount of soaking usefulness is 4000 kilograms.
Application examples
The traditional Chinese medicine composition extract liquid that embodiment 2 is obtained adopts concentrating under reduced pressure, is concentrated into 1/3 of former weight, gets the Chinese medicine composition concentrated solution, is used to prepare the whitening skin care product cream, the prescription such as the table 1 of this cream of whitening.
Table 1
Skin whitener
Production technology:
The first step: HANSHENGJIAO is dispersed in the deionized water, and elevated temperature to 80 ℃ simultaneously, adds other components of B phase then, stir;
Second step: each component of A phase is complete in 80 ℃ of dissolvings, stir; A is added to middle mutually homogenizing, about 4 minutes of stirring of B;
The 3rd step: add C and stirred fast mutually 1～2 minute, froth breaking is cooled to 65 ℃;
The 4th step: add the D phase, back to the 40 ℃ of addings that stir comprise each component of E phase of Chinese medicine composition concentrated solution, the discharging that stirs, and pH value is controlled at 4.0～5.0, makes the cream of whitening.
Chinese medicine composition suppresses melanin and promotes Skin Cell new life's laboratory report
1, tryrosinase suppresses experiment:
1.1, the preparation of whitening agent sample:
Reagent one: PBS (phosphate standard buffer solution), pH value 6.86
Reagent two: L-Dopa solution (with PBS preparation, concentration 0.15%)
Reagent three: tryrosinase solution (with the PBS preparation, concentration 200 μ/ml)
Reagent four: Chinese medicine composition whitening agent solution (with PBS Chinese medicine composition being made into mass concentration 0.2%, 0.5%, four kinds of solution of 1.0%, 2.0%)
Again the solution of every kind of concentration is prepared A, B, four samples of C, D according to table 2.
Table 2
1.2, the preparation of control sample:
Choose arbutin, licoflavone and three kinds of whitening additives commonly used of vitamin C as three matched groups.Each matched group is made into mass concentration 0.2% with PBS respectively, 0.5%, four kinds of solution of 1.0%, 2.0%, the solution of every kind of concentration are made into A, B, four samples of C, D (with the Chinese medicine composition solution in the matched group solution substitution list 2) respectively by the proportioning of table 2 again.
1.3, experimental result:
Table 3
Annotate: 475nm surveys absorbance.
The computational methods of tyrosinase inhibition rate:
Tyrosinase inhibition rate %=[(A-B)-(C-D)]/(A-B) * 100%
1.4, conclusion:
Adopt Chinese medicine composition of the present invention to suppress in the experiment, the suppression ratio of tryrosinase is higher than matched group at tryrosinase.
2, melanocyte In vitro culture experiment:
2.1, the preparation of the cream sample of whitening:
With PBS Chinese medicine composition is mixed with mass concentration 0.2%, 0.5%, four kinds of solution of 1.0%, 2.0%.
2.2, the preparation of control sample:
Choose arbutin, licoflavone and three kinds of whitening additives commonly used of vitamin C as three matched groups.Each matched group is made into mass concentration respectively 0.2%, 0.5% with PBS, four kinds of solution of 1.0%, 2.0%.
2.3, test method:
The trophophase B16 cell routine of taking the logarithm digestion, adjusting number of cells is 5 * 10
4Individual/ml, be seeded in 96 orifice plates every hole 90 μ L, CO
2After hatching 24 hours in the incubator, every hole adds with DMSO dissolving and filtering medicine (Chinese medicine composition or arbutin solution, licoflavone solution, vitamin c solution), and sets up the blank group of culture medium and cell;
After placing incubator to hatch 72 hours the culture plate, abandon supernatant, PBS washes two times, adds 100ml 1%Triton-100 then, shakes after 5 minutes, behind-20 ℃ of placement 1h, room temperature is melted makes the complete cracking of cell, follows every hole and adds 100 μ L, 0.1% levodopa solution (PBS joins), hatches in the incubator 1 hour, to cultivate the datum hole zeroing, under microplate reader, survey the absorbance of 460nm.
2.4, experimental result:
Table 4
2.5, conclusion:
Adopt Chinese medicine composition of the present invention in melanocyte In vitro culture experiment, the suppression ratio of melanocyte is higher than matched group, Chinese medicine composition is more satisfactory whitening composition.3, skin epidermis thickness measurement experiment:
3.1, the preparation of the cream sample of whitening:
With the prescription (table 1) of application examples and the prepared cream of whitening, be mixed with mass concentration 0.2%, 0.5%, 1.0% with the PBS cream of will whitening, smear again behind four kinds of solution of 2.0%.
3.2, test method:
Mouse back skin unhairing is smeared the solution of the cream of whitening, and does the skin histology section after 3 weeks, measures skin thickness with telescope callipers.
3.3, experimental result:
Table 5
| The Chinese medicine composition substrate concentration | ??0.2％ | ??0.5％ | ??1.0％ | ??2.0％ |
| Epidermal area thickness | ??0.03mm | ??0.05mm | ??0.05mm | ??0.06mm |
3.4, conclusion:
Adopt Chinese medicine composition of the present invention in the skin epidermis thickness measurement, new life has facilitation to epidermal area, and along with the increase of Chinese medicine composition substrate concentration, facilitation effect improves.
4, collagen content determination experiment:
4.1, the preparation of the cream sample of whitening:
With the prescription (table 1) of application examples and the prepared cream of whitening, be mixed with mass concentration 0.2%, 0.5%, 1.0% with the PBS cream of will whitening, smear again behind four kinds of solution of 2.0%.
4.2, test method:
Mouse back skin unhairing is smeared the solution that contains the cream of whitening, and measures hydroxyproline content (hydroxyproline content ÷ 13.6%=collagen content) after the back bark fetching skin tissue hydrolysis of 3 weeks.
4.3, experimental result:
Table 6
| The Chinese medicine composition substrate concentration | ??0.2％ | ??0.5％ | ??1.0％ | ??2.0％ |
| Hydroxyproline content | ??0.02 | ??0.04 | ??0.06 | ??0.06 |
4.4, conclusion:
Adopt Chinese medicine composition of the present invention in the collagen content determination experiment, new life has facilitation to skin corium, and along with the increase of Chinese medicine composition substrate concentration, facilitation effect improves.
Claims (8)
1, a kind of whitening and skin-protecting Chinese medicine composition, it is characterized in that: described Chinese medicine composition by the Pseudobulbus Bletillae (Rhizoma Bletillae), hold back in vain, the extract of Cortex Mori, Poria, Fructus Atriplicis Sibiricae, the Rhizoma Atractylodis Macrocephalae, Fructus Amomi Rotundus, the Radix Paeoniae Alba, Herba Pyrolae and Radix Angelicae Sinensis forms, and any one Chinese medicine extract all is no more than 20% of extract gross weight.
2, whitening and skin-protecting Chinese medicine composition according to claim 1, it is characterized in that: by weight percentage, the content of described each Chinese medicine extract is: the Pseudobulbus Bletillae (Rhizoma Bletillae) 1～20%, hold back 1～20% in vain, Cortex Mori 1～20%, Poria 1～20%, Fructus Atriplicis Sibiricae 1～20%, the Rhizoma Atractylodis Macrocephalae 1～20%, Fructus Amomi Rotundus 1～20%, the Radix Paeoniae Alba 1～20%, Herba Pyrolae 1～20% and Radix Angelicae Sinensis 1～20%.
3, whitening and skin-protecting Chinese medicine composition according to claim 1, it is characterized in that: by weight percentage, the content of described each Chinese medicine extract is: the Pseudobulbus Bletillae (Rhizoma Bletillae) 2～15%, hold back 2～15% in vain, Cortex Mori 2～15%, Poria 2～15%, Fructus Atriplicis Sibiricae 2～15%, the Rhizoma Atractylodis Macrocephalae 2～15%, Fructus Amomi Rotundus 2～15%, the Radix Paeoniae Alba 2～15%, Herba Pyrolae 5～20% and Radix Angelicae Sinensis 2～15%.
4, at the preparation method of the described whitening and skin-protecting Chinese medicine composition of one of claim 1 to 3, it is characterized in that: each Chinese medicinal components is used the alcohol-pickled of mass concentration 20%～80%, the ethanol consumption that soaks usefulness is 20～50 times of Chinese medicinal components gross weight, soak concentrates 10～50 times after filtering then, the concentrated solution macroporous resin adsorption, the ethanol of reuse mass concentration 10%～98% is eluting repeatedly, collects eluent, makes the traditional Chinese medicine composition extract liquid that comprises each Chinese medicine extract.
5, the preparation method of whitening and skin-protecting Chinese medicine composition according to claim 4, it is characterized in that: in immersion process, elder generation was with alcohol-pickled 2～48 hours of mass concentration 20%～80%, alcohol-pickled 2～48 hours of residue reuse mass concentration 20%～80%, merge the solution after soaking, get soak.
6, the preparation method of whitening and skin-protecting Chinese medicine composition according to claim 4 is characterized in that: in filter process, used filter screen order number is 180～250 orders.
7, the purposes of the whitening and skin-protecting Chinese medicine composition that makes at the described method of one of claim 4 to 6, be used to prepare whitening skin care product or medicine, comprise cream, paste, ointment, ointment, Emulsion, oil preparation, face film agent, gel, liniment, aerosol or solution.
8, the purposes of whitening and skin-protecting Chinese medicine composition according to claim 7, it is characterized in that: with the traditional Chinese medicine composition extract liquid that makes through being evaporated to 1/2～1/5 of former weight, obtain the Chinese medicine composition concentrated solution, be used to prepare whitening skin care product or medicine, wherein, described Chinese medicine composition concentrated solution accounts for 5～10% of whitening skin care product or medicine gross weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100558197A CN101612105B (en) | 2009-08-03 | 2009-08-03 | Whitening and skin-protecting traditional Chinese medicine composition and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100558197A CN101612105B (en) | 2009-08-03 | 2009-08-03 | Whitening and skin-protecting traditional Chinese medicine composition and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101612105A true CN101612105A (en) | 2009-12-30 |
| CN101612105B CN101612105B (en) | 2011-08-10 |
Family
ID=41492115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009100558197A Active CN101612105B (en) | 2009-08-03 | 2009-08-03 | Whitening and skin-protecting traditional Chinese medicine composition and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101612105B (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302440A (en) * | 2011-09-23 | 2012-01-04 | 孙丽华 | Chinese medicinal herb softening, whitening, anti-aging, wrinkle-smoothing and freckle-removing cosmetic composition |
| CN102846535A (en) * | 2012-09-14 | 2013-01-02 | 福建泉州恒泉化妆品有限公司 | Anti-freckle whitening beauty-restoring cream and manufacturing method thereof |
| CN103751552A (en) * | 2014-02-26 | 2014-04-30 | 广东轻工职业技术学院 | Traditional Chinese medicine composite with anti-aging effect, preparation method and application |
| CN104224682A (en) * | 2014-09-04 | 2014-12-24 | 叶集试验区刘金成养蜂专业合作社 | Honey facial mask and preparation method thereof |
| CN104721397A (en) * | 2015-03-03 | 2015-06-24 | 广西大学 | Traditional Chinese medicine composition |
| CN105662959A (en) * | 2016-02-03 | 2016-06-15 | 上海新高姿化妆品有限公司 | Natural plant composition with skin whitening effect and application thereof to cosmetics |
| CN108014059A (en) * | 2016-11-04 | 2018-05-11 | 无锡法瑞雅生物细胞科学有限公司 | A kind of skin whitening, moisturizing lotion and preparation method thereof |
| CN111467295A (en) * | 2020-06-02 | 2020-07-31 | 苏州逸纪杰电子科技有限公司 | Wrinkle-removing skin lotion with whitening effect and preparation method thereof |
| CN113940956A (en) * | 2021-11-05 | 2022-01-18 | 玉林师范学院 | Pharmaceutical composition with whitening effect, skin care product and application |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115177575A (en) * | 2022-07-13 | 2022-10-14 | 广州市万千粉丝化妆品有限公司 | Application of traditional Chinese medicine extract composition with whitening and freckle removing effects |
-
2009
- 2009-08-03 CN CN2009100558197A patent/CN101612105B/en active Active
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302440A (en) * | 2011-09-23 | 2012-01-04 | 孙丽华 | Chinese medicinal herb softening, whitening, anti-aging, wrinkle-smoothing and freckle-removing cosmetic composition |
| CN102846535A (en) * | 2012-09-14 | 2013-01-02 | 福建泉州恒泉化妆品有限公司 | Anti-freckle whitening beauty-restoring cream and manufacturing method thereof |
| CN103751552A (en) * | 2014-02-26 | 2014-04-30 | 广东轻工职业技术学院 | Traditional Chinese medicine composite with anti-aging effect, preparation method and application |
| CN104224682A (en) * | 2014-09-04 | 2014-12-24 | 叶集试验区刘金成养蜂专业合作社 | Honey facial mask and preparation method thereof |
| CN104721397A (en) * | 2015-03-03 | 2015-06-24 | 广西大学 | Traditional Chinese medicine composition |
| CN105662959A (en) * | 2016-02-03 | 2016-06-15 | 上海新高姿化妆品有限公司 | Natural plant composition with skin whitening effect and application thereof to cosmetics |
| CN105662959B (en) * | 2016-02-03 | 2018-07-06 | 上海新高姿化妆品有限公司 | A kind of natural plant composition with white-skinned face function and its application in cosmetics |
| CN108014059A (en) * | 2016-11-04 | 2018-05-11 | 无锡法瑞雅生物细胞科学有限公司 | A kind of skin whitening, moisturizing lotion and preparation method thereof |
| CN111467295A (en) * | 2020-06-02 | 2020-07-31 | 苏州逸纪杰电子科技有限公司 | Wrinkle-removing skin lotion with whitening effect and preparation method thereof |
| CN113940956A (en) * | 2021-11-05 | 2022-01-18 | 玉林师范学院 | Pharmaceutical composition with whitening effect, skin care product and application |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101612105B (en) | 2011-08-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101612105B (en) | Whitening and skin-protecting traditional Chinese medicine composition and preparation method thereof | |
| CN101367881B (en) | High-efficiency preparation method for glossy ganoderma polysaccharide | |
| CN107259561A (en) | Flower of Panax ginseng glue drink and preparation method thereof | |
| CN105434239B (en) | A kind of application of skin lightening compositions containing natural botanical source in cosmetics | |
| CN105132491A (en) | Pachymaran extracting method | |
| CN108403487B (en) | Preparation process of pine pollen extract | |
| CN113476356A (en) | Preparation method and application of pyracantha fortuneana fruit extract | |
| CN101690705B (en) | Preparation method of alpine pine needle active extract and whitening anti-aging active cosmetic | |
| CN101810704A (en) | Combination of traditional Chinese medicine extractive with function of removing acne, preparation and use | |
| CN109464329A (en) | A kind of goddess's jade flesh virtue proferment pulp cosmetic and the preparation method and application thereof | |
| CN115475123A (en) | Whitening and spot-fading composition and preparation method thereof | |
| CN114732752B (en) | Composition for skin whitening and use thereof | |
| CN115607492A (en) | Radix ceratostigmae callus extract and preparation method and application thereof | |
| CN115463064A (en) | Saussurea involucrate callus extract and preparation method and application thereof | |
| CN107669525A (en) | Application of Poria cocos extract solution with brilliant white effect and preparation method thereof | |
| CN102113993A (en) | Fine jade square and preparation method and application thereof | |
| CN103202787A (en) | Skin care composition with whitening function and usage thereof | |
| CN104586676A (en) | Plant formula for preventing and treating black eye and edema around eyes caused by staying-up all night and its preparation method and use | |
| CN112957291A (en) | Skin-whitening and anti-aging skin-care composition | |
| CN107233376B (en) | Spanish chrysanthemum extracting solution and preparation method and application thereof | |
| CN115025025B (en) | Paeonia lactiflora fermentation product and preparation method and application thereof | |
| CN111848376A (en) | Glaucocalyx rabdosia root extract, extraction and separation method and application thereof | |
| CN108653566B (en) | Traditional Chinese medicine composition with whitening effect and preparation method thereof | |
| CN105456145A (en) | Extraction method, extract and application of active constituents of ginkgo nuts | |
| CN116650380B (en) | Anti-aging tea fermentation product for improving skin microcirculation and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee | ||
| CP02 | Change in the address of a patent holder |
Address after: 200444 Shanghai city Baoshan District City Bank Road No. 121 Patentee after: Shanghai Inoherb Cosmetic Co., Ltd. Address before: 200083 Shanghai City No. 1 Lane 66 Huayuan Road Jiahe International Building 18-19 Patentee before: Shanghai Inoherb Cosmetic Co., Ltd. |